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Gene Dmel\Ahcy13

General Information
Symbol	Dmel\Ahcy13	Species	D. melanogaster
Name	Adenosylhomocysteinase at 13	Annotation symbol	CG11654
Feature type	protein_coding_gene	FlyBase ID	FBgn0014455
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	13C3-13C3	Sequence location	X:15,344,294..15,346,679 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adenosylhomocysteinase at 13 is referred to in FlyBase by the symbol Dmel\Ahcy13 (CG11654, FBgn0014455). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: adenosylhomocysteinase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: one-carbon metabolic process. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Adenosylhomocysteinase; NAD(P)-binding domain; S-adenosyl-L-homocysteine hydrolase, NAD binding domain; S-adenosyl-L-homocysteine hydrolase, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult salivary gland, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629222_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ahcy13. Gene sequence location is X:15344294..15346679.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms nucleotide binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13C3-13C3   Limits computationally determined from genome sequence between P{EP}hiwEP1308 and P{EP}Ahcy13EP1007
Experimentally Determined Cytological Location
Cytogenetic map Notes References 13C1-13C2   (determined by in situ hybridisation)   (Caggese et al., 1997) 13-13   (determined by in situ hybridisation)   (Caggese et al., 1995)
Experimentally Determined Recombination Data
Location	1- (Caggese et al., 1995)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ahcy13 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ahcy13-RA FBtr0074030  NM_078609   1598   432 Ahcy13-RB FBtr0332590  NM_001272644   1407   323
Additional Transcript Data & Comments
Reported size (kB)	1.8 (northern blot) (Caggese et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ahcy13-PA   FBpp0073847   47.4   432   6.14     NP_511164   AAF48453 Ahcy13-PB   FBpp0304841   35.6   323   6.00     NP_001259573   AGB95415
Additional Polypeptide Data & Comments
Reported size (kDa)	431 (aa) (Caggese et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenosylhomocysteinase (IPR000043) S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878) S-adenosyl-L-homocysteine hydrolase, conserved site (IPR020082) NAD(P)-binding domain (IPR016040)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA694901   AA695242   AA695290   AA695679   AA695835   AA735916   AA736044   AA801717   AA801764   AA801898   AA801976   AA802931   AA803389   AA803942   AA821069   AE014298 AAF48453   AE014298 AGB95415   AI062530   AI064077   AI108431   AI108878   AI387834   AI389394   AI532241   AI534059   AY102668 AAM27497   BF495573   BI354112   BI354646   BI371157   BI486125   BI564441   BI570890   BI571180   BI576332   BI576883   BI585993   BI589811   BI605724   BI612878   BI613820   BI621376   BI625596   BI627502   BI635519   BX008090   BX011649   BX015368   BX018499   BX022868   BX023317   BX032355   BX041634   BX052474   BX053929   BX058446   BX061390   CO275937   CO278164   CO283407   CO285044   CO296637   CO296659   CO306335   CO321773   CO338584   CO339542   DQ440384   EC073473   EC081119   EC084033   EC198684   EC200840   EC203343   EC211694   EC214943   EC228953   EC232245   EC236236   EC236266   EC258945   EC267155   EV580785   EV581381   EV591410   GH738998   GH739259   GH739717   GH739846   GH739909   GH740805   GH740862   GH741350   GH741884   GH743109   GH743476   GH744080   GH745444   GH745825   GH745942   GH746685   GH746770   GH746886   GH746948   GH747245   GH747327   GH747376   GH761576   GH761626   GH761651   GH761738   GH762079   GH762476   GH762701   GH762835   GH763158   GH763224   GH763514   GH763596   GH763739   GH764505   GH764859   GH765022   GH765052   GH765122   GH765328   GH765743   GH765841   GH765900   GH766054   GH766535   GH767064   GH767072   GH767271   GH767670   GH767953   GH768012   GH768134   GH768352   GH768614   GH768828   GH768840   GH768903   GH769096   GH769434   GH769743   X95636 CAA64892
UniProtKB/Swiss-Prot	Q27580
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Caggese et al., 1997)
Additional Descriptive Data
	Ahcy13 transcripts are observed at a nearly constant level in unfertilized eggs and throughout development on northern blots. (Caggese et al., 1997)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult salivary gland, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    679.45 Larval Midgut    409 Larval Hindgut    556.7 Larval Malpighian Tubules    372.1 Larval Fat Body    974.7 Larval Salivary Gland    1070.1 Larval Trachea    1425.775 Larval Carcass    844.925 Adult Head    562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules    1105.9 Adult Fat Body    1343.6 Adult Salivary Gland    266.2 Adult Heart    821.925 Adult VirginFemale Spermatheca    1513.3 Adult InseminatedFemale Spermatheca    1187.1 Adult Ovary    1365.4 Adult Testis    144.3 Adult Male Accessory Gland    1125.6 Adult Carcass    847.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (679.45) Larval Midgut    409 Larval Hindgut  (556.7) Larval Malpighian Tubules    372.1 Larval Fat Body  (974.7) Larval Salivary Gland  (1070.1) Larval Trachea  (1425.775) Larval Carcass  (844.925) Adult Head  (562.1) Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules  (1105.9) Adult Fat Body  (1343.6) Adult Salivary Gland    266.2 Adult Heart  (821.925) Adult VirginFemale Spermatheca  (1513.3) Adult InseminatedFemale Spermatheca  (1187.1) Adult Ovary  (1365.4) Adult Testis    144.3 Adult Male Accessory Gland  (1125.6) Adult Carcass  (847.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    679.45 Larval Midgut    409 Larval Hindgut    556.7 Larval Malpighian Tubules    372.1 Larval Fat Body    974.7 Larval Salivary Gland  1070.1 Larval Trachea  (1425.775) Larval Carcass    844.925 Adult Head    562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules  (1105.9) Adult Fat Body  (1343.6) Adult Salivary Gland    266.2 Adult Heart    821.925 Adult VirginFemale Spermatheca  (1513.3) Adult InseminatedFemale Spermatheca  (1187.1) Adult Ovary  (1365.4) Adult Testis    144.3 Adult Male Accessory Gland  (1125.6) Adult Carcass    847.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    679.45 Larval Midgut    409 Larval Hindgut    556.7 Larval Malpighian Tubules    372.1 Larval Fat Body    974.7 Larval Salivary Gland    1070.1 Larval Trachea    1425.775 Larval Carcass    844.925 Adult Head    562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules    1105.9 Adult Fat Body    1343.6 Adult Salivary Gland    266.2 Adult Heart    821.925 Adult VirginFemale Spermatheca    1513.3 Adult InseminatedFemale Spermatheca    1187.1 Adult Ovary    1365.4 Adult Testis    144.3 Adult Male Accessory Gland    1125.6 Adult Carcass    847.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    679.45 Larval Midgut    409 Larval Hindgut    556.7 Larval Malpighian Tubules    372.1 Larval Fat Body    974.7 Larval Salivary Gland    1070.1 Larval Trachea    1425.775 Larval Carcass    844.925 Adult Head    562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules    1105.9 Adult Fat Body    1343.6 Adult Salivary Gland    266.2 Adult Heart    821.925 Adult VirginFemale Spermatheca    1513.3 Adult InseminatedFemale Spermatheca    1187.1 Adult Ovary    1365.4 Adult Testis    144.3 Adult Male Accessory Gland    1125.6 Adult Carcass    847.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  679.45 Larval Midgut    409 Larval Hindgut  556.7 Larval Malpighian Tubules    372.1 Larval Fat Body  (974.7) Larval Salivary Gland  (1070.1) Larval Trachea  (1425.775) Larval Carcass  (844.925) Adult Head  562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules  (1105.9) Adult Fat Body  (1343.6) Adult Salivary Gland    266.2 Adult Heart  (821.925) Adult VirginFemale Spermatheca  (1513.3) Adult InseminatedFemale Spermatheca  (1187.1) Adult Ovary  (1365.4) Adult Testis    144.3 Adult Male Accessory Gland  (1125.6) Adult Carcass  (847.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    679.45 Larval Midgut    409 Larval Hindgut    556.7 Larval Malpighian Tubules    372.1 Larval Fat Body    974.7 Larval Salivary Gland  1070.1 Larval Trachea  1425.775 Larval Carcass    844.925 Adult Head    562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules  1105.9 Adult Fat Body  1343.6 Adult Salivary Gland    266.2 Adult Heart    821.925 Adult VirginFemale Spermatheca  1513.3 Adult InseminatedFemale Spermatheca  1187.1 Adult Ovary  1365.4 Adult Testis    144.3 Adult Male Accessory Gland  1125.6 Adult Carcass    847.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    679.45 Larval Midgut    409 Larval Hindgut    556.7 Larval Malpighian Tubules    372.1 Larval Fat Body    974.7 Larval Salivary Gland    1070.1 Larval Trachea    1425.775 Larval Carcass    844.925 Adult Head    562.1 Adult Eye    458.2 Adult Brain    180 Adult Thoracic-Abdominal Ganglion    163.9 Adult Crop    413.8 Adult Midgut    369.1 Adult Hindgut    363.8 Adult Malpighian Tubules    1105.9 Adult Fat Body    1343.6 Adult Salivary Gland    266.2 Adult Heart    821.925 Adult VirginFemale Spermatheca    1513.3 Adult InseminatedFemale Spermatheca    1187.1 Adult Ovary    1365.4 Adult Testis    144.3 Adult Male Accessory Gland    1125.6 Adult Carcass    847.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    562.1   NA  Eye    458.2   NA  Brain    180   679.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    163.9   NA  Crop    413.8   409  Midgut    369.1   556.7  Hindgut    363.8   372.1  Malpighian Tubules    1105.9   974.7  Fat Body    1343.6   1070.1  Salivary Gland    266.2   NA  Heart    821.925   1425.775  Trachea    NA   NA  VirginFemale Spermatheca    1513.3   NA  InseminatedFemale Spermatheca    1187.1   NA  Ovary    1365.4   NA  Testis    144.3   NA  Male Accessory Gland    1125.6   844.925  Carcass    847.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    113 central nervous system, larvae L3    76 central nervous system, pupae P8    19 head, virgin 1-day female    54 head, virgin 4-day female    48 head, virgin 20-day female    79 head, mated 1-day female    34 head, mated 4-day female    68 head, mated 20-day female    70 head, mated 1-day male    41 head, mated 4-day male    48 head, mated 20-day male    67 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    88 digestive system, 4-day adult    72 digestive system, 20-day adult    77 fat body, larvae L3 wandering    175 fat body, white prepupae    44 fat body, pupae P8    42 carcass, larvae L3 wandering    65 carcass, 1-day adult    56 carcass, 4-day adult    87 carcass, 20-day adult    103 ovary, virgin 4-day female    257 ovary, mated 4-day female    227 testis, mated 4-day male    57 accessory gland, mated 4-day male    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (113) central nervous system, larvae L3  (76) central nervous system, pupae P8    19 head, virgin 1-day female  (54) head, virgin 4-day female  (48) head, virgin 20-day female  (79) head, mated 1-day female  (34) head, mated 4-day female  (68) head, mated 20-day female  (70) head, mated 1-day male  (41) head, mated 4-day male  (48) head, mated 20-day male  (67) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering  (45) digestive system, 1-day adult  (88) digestive system, 4-day adult  (72) digestive system, 20-day adult  (77) fat body, larvae L3 wandering  (175) fat body, white prepupae  (44) fat body, pupae P8  (42) carcass, larvae L3 wandering  (65) carcass, 1-day adult  (56) carcass, 4-day adult  (87) carcass, 20-day adult  (103) ovary, virgin 4-day female  (257) ovary, mated 4-day female  (227) testis, mated 4-day male  (57) accessory gland, mated 4-day male  (63) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (113) central nervous system, larvae L3    76 central nervous system, pupae P8    19 head, virgin 1-day female    54 head, virgin 4-day female    48 head, virgin 20-day female    79 head, mated 1-day female    34 head, mated 4-day female    68 head, mated 20-day female    70 head, mated 1-day male    41 head, mated 4-day male    48 head, mated 20-day male    67 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    88 digestive system, 4-day adult    72 digestive system, 20-day adult    77 fat body, larvae L3 wandering  (175) fat body, white prepupae    44 fat body, pupae P8    42 carcass, larvae L3 wandering    65 carcass, 1-day adult    56 carcass, 4-day adult    87 carcass, 20-day adult  103 ovary, virgin 4-day female  (257) ovary, mated 4-day female  (227) testis, mated 4-day male    57 accessory gland, mated 4-day male    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    113 central nervous system, larvae L3    76 central nervous system, pupae P8    19 head, virgin 1-day female    54 head, virgin 4-day female    48 head, virgin 20-day female    79 head, mated 1-day female    34 head, mated 4-day female    68 head, mated 20-day female    70 head, mated 1-day male    41 head, mated 4-day male    48 head, mated 20-day male    67 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    88 digestive system, 4-day adult    72 digestive system, 20-day adult    77 fat body, larvae L3 wandering    175 fat body, white prepupae    44 fat body, pupae P8    42 carcass, larvae L3 wandering    65 carcass, 1-day adult    56 carcass, 4-day adult    87 carcass, 20-day adult    103 ovary, virgin 4-day female    257 ovary, mated 4-day female    227 testis, mated 4-day male    57 accessory gland, mated 4-day male    63 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    113 central nervous system, larvae L3    76 central nervous system, pupae P8    19 head, virgin 1-day female    54 head, virgin 4-day female    48 head, virgin 20-day female    79 head, mated 1-day female    34 head, mated 4-day female    68 head, mated 20-day female    70 head, mated 1-day male    41 head, mated 4-day male    48 head, mated 20-day male    67 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    88 digestive system, 4-day adult    72 digestive system, 20-day adult    77 fat body, larvae L3 wandering    175 fat body, white prepupae    44 fat body, pupae P8    42 carcass, larvae L3 wandering    65 carcass, 1-day adult    56 carcass, 4-day adult    87 carcass, 20-day adult    103 ovary, virgin 4-day female    257 ovary, mated 4-day female    227 testis, mated 4-day male    57 accessory gland, mated 4-day male    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (113) central nervous system, larvae L3  (76) central nervous system, pupae P8    19 head, virgin 1-day female  (54) head, virgin 4-day female  (48) head, virgin 20-day female  (79) head, mated 1-day female  (34) head, mated 4-day female  (68) head, mated 20-day female  (70) head, mated 1-day male  (41) head, mated 4-day male  (48) head, mated 20-day male  (67) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering  (45) digestive system, 1-day adult  (88) digestive system, 4-day adult  (72) digestive system, 20-day adult  (77) fat body, larvae L3 wandering  (175) fat body, white prepupae  (44) fat body, pupae P8  (42) carcass, larvae L3 wandering  (65) carcass, 1-day adult  (56) carcass, 4-day adult  (87) carcass, 20-day adult  (103) ovary, virgin 4-day female  (257) ovary, mated 4-day female  (227) testis, mated 4-day male  (57) accessory gland, mated 4-day male  (63) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  113 central nervous system, larvae L3    76 central nervous system, pupae P8    19 head, virgin 1-day female    54 head, virgin 4-day female    48 head, virgin 20-day female    79 head, mated 1-day female    34 head, mated 4-day female    68 head, mated 20-day female    70 head, mated 1-day male    41 head, mated 4-day male    48 head, mated 20-day male    67 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    88 digestive system, 4-day adult    72 digestive system, 20-day adult    77 fat body, larvae L3 wandering  (175) fat body, white prepupae    44 fat body, pupae P8    42 carcass, larvae L3 wandering    65 carcass, 1-day adult    56 carcass, 4-day adult    87 carcass, 20-day adult  103 ovary, virgin 4-day female  (257) ovary, mated 4-day female  (227) testis, mated 4-day male    57 accessory gland, mated 4-day male    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    113 central nervous system, larvae L3    76 central nervous system, pupae P8    19 head, virgin 1-day female    54 head, virgin 4-day female    48 head, virgin 20-day female    79 head, mated 1-day female    34 head, mated 4-day female    68 head, mated 20-day female    70 head, mated 1-day male    41 head, mated 4-day male    48 head, mated 20-day male    67 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    88 digestive system, 4-day adult    72 digestive system, 20-day adult    77 fat body, larvae L3 wandering    175 fat body, white prepupae    44 fat body, pupae P8    42 carcass, larvae L3 wandering    65 carcass, 1-day adult    56 carcass, 4-day adult    87 carcass, 20-day adult    103 ovary, virgin 4-day female    257 ovary, mated 4-day female    227 testis, mated 4-day male    57 accessory gland, mated 4-day male    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    186 embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr    58 embryo 08-10hr    74 embryo 10-12hr    115 embryo 12-14hr    70 embryo 14-16hr    90 embryo 16-18hr    59 embryo 18-20hr    47 embryo 20-22hr    73 embryo 22-24hr    60 larva L1    418 larva L2    223 larva L3 12hr old    295 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    48 white prepupae new    42 white prepupae 12hr    45 white prepupae 24hr    52 pupae 2d postWPP    44 pupae 3d postWPP    36 pupae 4d postWPP    46 adult male 01day    35 adult male 05day    37 adult male 30day    55 adult female 01day    227 adult female 05day    211 adult female 30day    227 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (186) embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr  (58) embryo 08-10hr  (74) embryo 10-12hr  (115) embryo 12-14hr  (70) embryo 14-16hr  (90) embryo 16-18hr  (59) embryo 18-20hr  (47) embryo 20-22hr  (73) embryo 22-24hr  (60) larva L1  (418) larva L2  (223) larva L3 12hr old  (295) larva L3 puffstage 1-2  (65) larva L3 puffstage 3-6  (55) larva L3 puffstage 7-9  (48) white prepupae new  (42) white prepupae 12hr  (45) white prepupae 24hr  (52) pupae 2d postWPP  (44) pupae 3d postWPP  (36) pupae 4d postWPP  (46) adult male 01day  (35) adult male 05day  (37) adult male 30day  (55) adult female 01day  (227) adult female 05day  (211) adult female 30day  (227) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (186) embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr    58 embryo 08-10hr    74 embryo 10-12hr  (115) embryo 12-14hr    70 embryo 14-16hr    90 embryo 16-18hr    59 embryo 18-20hr    47 embryo 20-22hr    73 embryo 22-24hr    60 larva L1  (418) larva L2  (223) larva L3 12hr old  (295) larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    48 white prepupae new    42 white prepupae 12hr    45 white prepupae 24hr    52 pupae 2d postWPP    44 pupae 3d postWPP    36 pupae 4d postWPP    46 adult male 01day    35 adult male 05day    37 adult male 30day    55 adult female 01day  (227) adult female 05day  (211) adult female 30day  (227) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    186 embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr    58 embryo 08-10hr    74 embryo 10-12hr    115 embryo 12-14hr    70 embryo 14-16hr    90 embryo 16-18hr    59 embryo 18-20hr    47 embryo 20-22hr    73 embryo 22-24hr    60 larva L1    418 larva L2    223 larva L3 12hr old    295 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    48 white prepupae new    42 white prepupae 12hr    45 white prepupae 24hr    52 pupae 2d postWPP    44 pupae 3d postWPP    36 pupae 4d postWPP    46 adult male 01day    35 adult male 05day    37 adult male 30day    55 adult female 01day    227 adult female 05day    211 adult female 30day    227 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    186 embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr    58 embryo 08-10hr    74 embryo 10-12hr    115 embryo 12-14hr    70 embryo 14-16hr    90 embryo 16-18hr    59 embryo 18-20hr    47 embryo 20-22hr    73 embryo 22-24hr    60 larva L1    418 larva L2    223 larva L3 12hr old    295 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    48 white prepupae new    42 white prepupae 12hr    45 white prepupae 24hr    52 pupae 2d postWPP    44 pupae 3d postWPP    36 pupae 4d postWPP    46 adult male 01day    35 adult male 05day    37 adult male 30day    55 adult female 01day    227 adult female 05day    211 adult female 30day    227 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (186) embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr  (58) embryo 08-10hr  (74) embryo 10-12hr  (115) embryo 12-14hr  (70) embryo 14-16hr  (90) embryo 16-18hr  (59) embryo 18-20hr  (47) embryo 20-22hr  (73) embryo 22-24hr  (60) larva L1  (418) larva L2  (223) larva L3 12hr old  (295) larva L3 puffstage 1-2  (65) larva L3 puffstage 3-6  (55) larva L3 puffstage 7-9  (48) white prepupae new  (42) white prepupae 12hr  (45) white prepupae 24hr  (52) pupae 2d postWPP  (44) pupae 3d postWPP  (36) pupae 4d postWPP  (46) adult male 01day  (35) adult male 05day  (37) adult male 30day  (55) adult female 01day  (227) adult female 05day  (211) adult female 30day  (227) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (186) embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr    58 embryo 08-10hr    74 embryo 10-12hr  115 embryo 12-14hr    70 embryo 14-16hr    90 embryo 16-18hr    59 embryo 18-20hr    47 embryo 20-22hr    73 embryo 22-24hr    60 larva L1  (418) larva L2  (223) larva L3 12hr old  (295) larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    48 white prepupae new    42 white prepupae 12hr    45 white prepupae 24hr    52 pupae 2d postWPP    44 pupae 3d postWPP    36 pupae 4d postWPP    46 adult male 01day    35 adult male 05day    37 adult male 30day    55 adult female 01day  (227) adult female 05day  (211) adult female 30day  (227) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    186 embryo 02-04hr    16 embryo 04-06hr    23 embryo 06-08hr    58 embryo 08-10hr    74 embryo 10-12hr    115 embryo 12-14hr    70 embryo 14-16hr    90 embryo 16-18hr    59 embryo 18-20hr    47 embryo 20-22hr    73 embryo 22-24hr    60 larva L1    418 larva L2    223 larva L3 12hr old    295 larva L3 puffstage 1-2    65 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    48 white prepupae new    42 white prepupae 12hr    45 white prepupae 24hr    52 pupae 2d postWPP    44 pupae 3d postWPP    36 pupae 4d postWPP    46 adult male 01day    35 adult male 05day    37 adult male 30day    55 adult female 01day    227 adult female 05day    211 adult female 30day    227 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    132 Schneider line 2 Sg4    329 embryonic 1182-4H    146 embryonic GM2    178 embryonic Kc167    68 embryonic S1    100 embryonic S3    314 leg disc CME L1    297 wing disc CME-W2    126 wing disc ML-DmD8    218 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    66 wing disc ML-DmD21    374 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    226 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    75 tumorous blood cells mbn2    61 ovary fGS/OSS    108 ovary OSC    62 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (132) Schneider line 2 Sg4  (329) embryonic 1182-4H  (146) embryonic GM2  (178) embryonic Kc167  (68) embryonic S1  (100) embryonic S3  (314) leg disc CME L1  (297) wing disc CME-W2  (126) wing disc ML-DmD8  (218) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3  (66) wing disc ML-DmD21  (374) wing disc ML-DmD32  (129) haltere disc ML-DmD17-c3  (103) eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (226) CNS ML-DmBG1-c1  (107) CNS ML-DmBG2-c2  (75) tumorous blood cells mbn2  (61) ovary fGS/OSS  (108) ovary OSC  (62) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (132) Schneider line 2 Sg4  (329) embryonic 1182-4H  (146) embryonic GM2  (178) embryonic Kc167    68 embryonic S1    100 embryonic S3  (314) leg disc CME L1  (297) wing disc CME-W2  (126) wing disc ML-DmD8  (218) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3    66 wing disc ML-DmD21  (374) wing disc ML-DmD32  (129) haltere disc ML-DmD17-c3  103 eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (226) CNS ML-DmBG1-c1  107 CNS ML-DmBG2-c2    75 tumorous blood cells mbn2    61 ovary fGS/OSS  (108) ovary OSC    62 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    132 Schneider line 2 Sg4    329 embryonic 1182-4H    146 embryonic GM2    178 embryonic Kc167    68 embryonic S1    100 embryonic S3    314 leg disc CME L1    297 wing disc CME-W2    126 wing disc ML-DmD8    218 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    66 wing disc ML-DmD21    374 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    226 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    75 tumorous blood cells mbn2    61 ovary fGS/OSS    108 ovary OSC    62 ovary OSS    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    132 Schneider line 2 Sg4    329 embryonic 1182-4H    146 embryonic GM2    178 embryonic Kc167    68 embryonic S1    100 embryonic S3    314 leg disc CME L1    297 wing disc CME-W2    126 wing disc ML-DmD8    218 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    66 wing disc ML-DmD21    374 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    226 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    75 tumorous blood cells mbn2    61 ovary fGS/OSS    108 ovary OSC    62 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (132) Schneider line 2 Sg4  (329) embryonic 1182-4H  (146) embryonic GM2  (178) embryonic Kc167  (68) embryonic S1  (100) embryonic S3  (314) leg disc CME L1  (297) wing disc CME-W2  (126) wing disc ML-DmD8  (218) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3  (66) wing disc ML-DmD21  (374) wing disc ML-DmD32  (129) haltere disc ML-DmD17-c3  (103) eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (226) CNS ML-DmBG1-c1  (107) CNS ML-DmBG2-c2  (75) tumorous blood cells mbn2  (61) ovary fGS/OSS  (108) ovary OSC  (62) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  132 Schneider line 2 Sg4  (329) embryonic 1182-4H  (146) embryonic GM2  (178) embryonic Kc167    68 embryonic S1    100 embryonic S3  (314) leg disc CME L1  (297) wing disc CME-W2  126 wing disc ML-DmD8  (218) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3    66 wing disc ML-DmD21  (374) wing disc ML-DmD32  129 haltere disc ML-DmD17-c3  103 eye-antennal disc ML-DmD11  (189) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (226) CNS ML-DmBG1-c1  107 CNS ML-DmBG2-c2    75 tumorous blood cells mbn2    61 ovary fGS/OSS  108 ovary OSC    62 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    132 Schneider line 2 Sg4    329 embryonic 1182-4H    146 embryonic GM2    178 embryonic Kc167    68 embryonic S1    100 embryonic S3    314 leg disc CME L1    297 wing disc CME-W2    126 wing disc ML-DmD8    218 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    66 wing disc ML-DmD21    374 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    189 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    226 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    75 tumorous blood cells mbn2    61 ovary fGS/OSS    108 ovary OSC    62 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    86 cold shock, 4-day adult    60 heat shock, 4-day adult    157 Cadmium 50 mM 6 hrs, larvae L3    156 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    135 Cadmium 100 mM 48 hrs, 4-day adult    174 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    252 Ethanol 5% 3 hrs, larvae L3    106 Ethanol 10% 3 hrs, larvae L3    136 Caffeine 1.5 mg/ml 4 hrs, larvae L3    84 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    230 Caffeine 25 mg/ml 48 hrs, 4-day adult    76 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    182 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    220 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (86) cold shock, 4-day adult  (60) heat shock, 4-day adult  (157) Cadmium 50 mM 6 hrs, larvae L3  (156) Cadmium 50 mM 12 hrs, larvae L3  (64) Cadmium 50 mM 48 hrs, 4-day adult  (135) Cadmium 100 mM 48 hrs, 4-day adult  (174) Copper 0.5 mM 12 hrs, larvae L3  (92) Copper 15 mM 48 hrs, 4-day adult  (53) Zinc 5 mM 12 hrs, larvae L3  (67) Zinc 4.5 mM 48 hrs, 4-day adult  (42) Ethanol 2.5% 3 hrs, larvae L3  (252) Ethanol 5% 3 hrs, larvae L3  (106) Ethanol 10% 3 hrs, larvae L3  (136) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (84) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (230) Caffeine 25 mg/ml 48 hrs, 4-day adult  (76) Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (182) Rotenone 2 μg 12 hrs, larvae L3  (142) Rotenone 8 μg 12 hrs, larvae L3  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    86 cold shock, 4-day adult    60 heat shock, 4-day adult  (157) Cadmium 50 mM 6 hrs, larvae L3  (156) Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult  (135) Cadmium 100 mM 48 hrs, 4-day adult  (174) Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3  (252) Ethanol 5% 3 hrs, larvae L3  106 Ethanol 10% 3 hrs, larvae L3  (136) Caffeine 1.5 mg/ml 4 hrs, larvae L3    84 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (230) Caffeine 25 mg/ml 48 hrs, 4-day adult    76 Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (182) Rotenone 2 μg 12 hrs, larvae L3  (142) Rotenone 8 μg 12 hrs, larvae L3  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    86 cold shock, 4-day adult    60 heat shock, 4-day adult    157 Cadmium 50 mM 6 hrs, larvae L3    156 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    135 Cadmium 100 mM 48 hrs, 4-day adult    174 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    252 Ethanol 5% 3 hrs, larvae L3    106 Ethanol 10% 3 hrs, larvae L3    136 Caffeine 1.5 mg/ml 4 hrs, larvae L3    84 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    230 Caffeine 25 mg/ml 48 hrs, 4-day adult    76 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    182 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    220 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    86 cold shock, 4-day adult    60 heat shock, 4-day adult    157 Cadmium 50 mM 6 hrs, larvae L3    156 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    135 Cadmium 100 mM 48 hrs, 4-day adult    174 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    252 Ethanol 5% 3 hrs, larvae L3    106 Ethanol 10% 3 hrs, larvae L3    136 Caffeine 1.5 mg/ml 4 hrs, larvae L3    84 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    230 Caffeine 25 mg/ml 48 hrs, 4-day adult    76 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    182 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    220 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (86) cold shock, 4-day adult  (60) heat shock, 4-day adult  (157) Cadmium 50 mM 6 hrs, larvae L3  (156) Cadmium 50 mM 12 hrs, larvae L3  (64) Cadmium 50 mM 48 hrs, 4-day adult  (135) Cadmium 100 mM 48 hrs, 4-day adult  (174) Copper 0.5 mM 12 hrs, larvae L3  (92) Copper 15 mM 48 hrs, 4-day adult  (53) Zinc 5 mM 12 hrs, larvae L3  (67) Zinc 4.5 mM 48 hrs, 4-day adult  (42) Ethanol 2.5% 3 hrs, larvae L3  (252) Ethanol 5% 3 hrs, larvae L3  (106) Ethanol 10% 3 hrs, larvae L3  (136) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (84) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (230) Caffeine 25 mg/ml 48 hrs, 4-day adult  (76) Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (182) Rotenone 2 μg 12 hrs, larvae L3  (142) Rotenone 8 μg 12 hrs, larvae L3  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    86 cold shock, 4-day adult    60 heat shock, 4-day adult  (157) Cadmium 50 mM 6 hrs, larvae L3  (156) Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult  135 Cadmium 100 mM 48 hrs, 4-day adult  (174) Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3  (252) Ethanol 5% 3 hrs, larvae L3  106 Ethanol 10% 3 hrs, larvae L3  136 Caffeine 1.5 mg/ml 4 hrs, larvae L3    84 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (230) Caffeine 25 mg/ml 48 hrs, 4-day adult    76 Paraquat 5 mM 48 hrs, 4-day adult  (154) Paraquat 10 mM 48 hrs, 4-day adult  (182) Rotenone 2 μg 12 hrs, larvae L3  142 Rotenone 8 μg 12 hrs, larvae L3  (220) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    86 cold shock, 4-day adult    60 heat shock, 4-day adult    157 Cadmium 50 mM 6 hrs, larvae L3    156 Cadmium 50 mM 12 hrs, larvae L3    64 Cadmium 50 mM 48 hrs, 4-day adult    135 Cadmium 100 mM 48 hrs, 4-day adult    174 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    42 Ethanol 2.5% 3 hrs, larvae L3    252 Ethanol 5% 3 hrs, larvae L3    106 Ethanol 10% 3 hrs, larvae L3    136 Caffeine 1.5 mg/ml 4 hrs, larvae L3    84 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    230 Caffeine 25 mg/ml 48 hrs, 4-day adult    76 Paraquat 5 mM 48 hrs, 4-day adult    154 Paraquat 10 mM 48 hrs, 4-day adult    182 Rotenone 2 μg 12 hrs, larvae L3    142 Rotenone 8 μg 12 hrs, larvae L3    220 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GM02466 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014455 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11654-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ahcy13 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ahcy13GD7355 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ahcy13 Class Mutagen Stocks Known lesion Ahcy13EP1007 P-element activity 2 -- Ahcy13CB-5251-3 1 -- Ahcy13NP5109 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ahcy13 Class Mutagen Stocks Known lesion Ahcy13GD7355 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ahcy13KK109393 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ahcy13NIG.11654R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)shtd2 (Tanaka-Matakatsu et al., 2007)
Partially disrupted in	Df(1)shtdEPDelta (Tanaka-Matakatsu et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7355} NA P{KK109393} NA P{NIG.11654R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Ahcy13EP1007 NA P{EP}EP1593 NA miscellaneous insertions P{RS3}Ahcy13CB-5251-3 NA insertion of enhancer trap binary system P{GawB}Ahcy13NP5109 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
adenosylhomocysteinase activity inferred from sequence or structural similarity with EMBL:M61832 AND inferred from sequence or structural similarity with EMBL:S57284 AND inferred from sequence or structural similarity with EMBL:U18796 (Caggese et al., 1997) inferred from sequence or structural similarity with mouse Ahcy (FlyBase, 1992-) non-traceable author statement (Caggese, 1996.2.12, Swiss-Prot Project Members, 1998.12.15)
Biological Process
CV term Evidence References
one-carbon metabolic process inferred from electronic annotation with InterPro:IPR000043, InterPro:IPR020082 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ahcy13 - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG13144 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG15044 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG15425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG1637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG2887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CG31800 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ahcy13 - CG5888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - Dic61B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - Hsp60B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - Mcm3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - RnrL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - dah anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - pio anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - rpr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ahcy13 - wcd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ahcy13 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58824 DroID - A comprehensive database of gene and protein interactions. • FBgn0014455 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32471
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SJ60M Dipteran inclusive ortholog search EOG6W9JCC Insect inclusive ortholog search EOG6H7170 Arthropod inclusive ortholog search EOG6RJDGX Metazoa inclusive ortholog search EOG638473
Orthologs in Drosophila Species (EOG6SJ60M)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ahcy13     Drosophila simulans   Dsim\GD17210 Y   Drosophila sechellia   Dsec\GM19564 Y   Drosophila erecta   Dere\GG17878 Y   Drosophila yakuba   Dyak\GE17184 Y   Drosophila ananassae   Dana\GF21238 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11121 Y   Drosophila persimilis   Dper\GL14580 Y   Drosophila willistoni   Dwil\GK19859 Y   Drosophila virilis   Dvir\GJ16855 Y   Drosophila mojavensis   Dmoj\GI15339 Y   Drosophila grimshawi   Dgri\GH24475 Y
Orthologs in non-Drosophila Dipterans (EOG6W9JCC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008341   Anopheles gambiae Malaria mosquito  Agam\Ahcy13   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008116
Orthologs in non-Dipteran Insects (EOG6H7170)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408368   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000193   Acromyrmex echinatior Panamanian leafcutter ant  Aech\ahcY   Atta cephalotes Leafcutter ant  Acep\ahcY   Camponotus floridanus Florida carpenter ant  Cflo\ahcY   Harpegnathos saltator Jerdons jumping ant  Hsal\ahcY   Linepithema humile Argentine ant  Lhum\LH12218   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23318   Solenopsis invicta Red fire ant  Sinv\SINV24427   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003908   Bombyx mori Silkmoth  Bmor\BGIBMGA011168   Pediculus humanus Human body louse  Phum\PHUM137320   Tribolium castaneum Red flour beetle  Tcas\TC014564
Orthologs in non-Insect Arthropods (EOG6RJDGX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ahcY   Ixodes scapularis Deer tick  Isca\ISCW015944
Orthologs in non-Arthropod Metazoa (EOG638473)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ahcy-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013770gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017727gn Y Danio rerio Zebrafish  Drer\zgc:158222 Y Danio rerio Zebrafish  Drer\ahcyl2 Y Danio rerio Zebrafish  Drer\ahcy Y Danio rerio Zebrafish  Drer\ahcyl1 Y Xenopus tropicalis Western clawed frog  Xtro\ahcy Y Xenopus tropicalis Western clawed frog  Xtro\ahcyl2 Y Xenopus tropicalis Western clawed frog  Xtro\ahcyl1 Y Gallus gallus Domestic chicken  Ggal\AHCY Y Gallus gallus Domestic chicken  Ggal\AHCYL2 Y Gallus gallus Domestic chicken  Ggal\AHCYL1 Y Mus musculus House mouse  Mmus\Ahcyl1 Y Mus musculus House mouse  Mmus\Ahcy Y Mus musculus House mouse  Mmus\Ahcyl2 Y Mus musculus House mouse  Mmus\Ahcy Y Rattus norvegicus Norway rat  Rnor\Ahcyl1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025827 Y Rattus norvegicus Norway rat  Rnor\Ahcy Y Rattus norvegicus Norway rat  Rnor\Ahcyl2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000013206 Y Homo sapiens Human  Hsap\AHCYL1 Y Homo sapiens Human  Hsap\AHCYL2 Y Homo sapiens Human  Hsap\AHCY Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\AHCYL1     Hsap\AHCYL2     Hsap\AHCY
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17210 Drosophila sechellia Dsec\GM19564 Drosophila erecta Dere\GG17878 Drosophila yakuba Dyak\GE17184 Drosophila ananassae Dana\GF21238 Drosophila pseudoobscura pseudoobscura Dpse\GA11121 Drosophila persimilis Dper\GL14580 Drosophila willistoni Dwil\GK19859 Drosophila virilis Dvir\GJ16855 Drosophila mojavensis Dmoj\GI15339 Drosophila grimshawi Dgri\GH24475
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	10129 w1118 P{EP}Ahcy13EP1007
Kyoto	101209 w1118 P{EP}Ahcy13EP1007 123529 w1118 P{RS3}Ahcy13CB-5251-3 104856 y* w* P{GawB}Ahcy13NP5109 / FM7c
VDRC	v104500 P{KK109393}VIE-260B v16251 w1118; P{GD7355}v16251
Genomic Clones ( 1 )
	BACR36D15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 130 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM02466
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04520 GH01756 GH04339 GH07262 GH08182 GH18503 GH20551 GM01754 GM02544 GM03258 GM03392 GM03554 GM03664 GM04568 GM06153 GM06584 GM10094 GM10762 GM10866 GM12322 GM12938 GM26342 GM27729 RE57989 RE69492 RH03304 RH05676 RH06009 RH25711 RH32871 RH33536 RH41867 RH43062 RH52710 RH61717 RH66054 RH68838 RH71613 SD03664 SD06549 SD16888
Other clones	1978 16960 17841 43427 59704 66092 80937 81344 144626 149440 214219.25 572818 CK01.7C.B2 CK01.68C.D8 Dmel_dig_012774_0663_0681 Dmel_dig_012820_0597_0766 Dmel_neb_010323_0401_0332 EK119203 EK129119 EK163054 EK168049 EK186341 EK214517 EK214606 EK250816 EN17131 EP02223 RP001001300 RP001003577 RP001005494 RP001005656 RP001006122 RP001006324 RP001006832 RP001007708 RP001009075 RP001009414 RP001009419 RP001011685 RP001011706 RP001012247 RP001012544 RP001012985 RP001017093 RP001017138 RP001017284 RP001017820 RP001018385 RP001018546 RP001018903 RP001019366 RP001019789 RP001021375 RP001021703 RP001025266 RP001026455 RP001028382 RP001030320 RP001030476 RP001032030 RP001032068 RP001032367 RP001033469 RP001033735 RP001035409 RP001037844 RP001043126 RP001044496 RP001045096 RP001046821 RP001047542 RP001047553 RP001048195 RP001048897 RP001049125 RP001049391 RP001049469 RP001050119 RP001050452 RP001051238 RP001053609 RP001053859 RP001053917 RP001054462 RP001054788 RP001056016 RP001056161 RP001056251
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014455 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32471
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ahcy13 CG11654 (Zhang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Identified by screening an ovarian expression library with polyclonal antibodies raised against Drosophila mitochondrial proteins in the 40-45kD range. (Caggese et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078609 NM_001272644 RefSeq (Proteins) • NP_511164 NP_001259573 DDBJ / EMBL / GenBank • AA695242 AAF48453 AAM27497 AGB95415 AY102668 CAA64892 X95636 Entrez Gene - A searchable database of RefSeq genes. • 32471 UniProtKB/Swiss-Prot • Q27580
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenosylhomocysteinase (IPR000043) S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878) S-adenosyl-L-homocysteine hydrolase, conserved site (IPR020082) NAD(P)-binding domain (IPR016040) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM02466
Linkouts
	BioGRID - A database of protein and genetic interactions • 58824 DroID - A comprehensive database of gene and protein interactions. • FBgn0014455 DRSC - Results from RNAi screens. • FBgn0014455 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014455 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11654-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014455 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32471 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32471 modMine - Data generated by the modENCODE project. • FBgn0014455
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ahcY (Caggese, 1996.2.12, ) Ahcy13 (Gruenewald et al., 2009, Quinones-Coello, 2007, Tanaka-Matakatsu et al., 2007, Japanese National Institute of Genetics, 2012.5.21) CG11654 (Pile et al., 2003, Labourier et al., 2002, Quinones-Coello, 2007, Keleman et al., 2009.8.5) SAHH (Mushegian et al., 1998)
Name Synonym	Adenosylhomocysteinase at 13   AdoHcyase (Caggese et al., 1997) S-Adenosyl-L-homocysteine hydrolase (Caggese et al., 1995)
Secondary FlyBase IDs
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...