Gene model reviewed during 5.49
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp4e2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cyp4e2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.
Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.
Identified molecularly using degenerate PCR primers designed from conserved regions of known insect P450 genes.
Overexpressed in the Raleigh DDT resistant strain. Cyp4e2 is inducible by phenobarbitol.
The adenylate cyclase inactivator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin inhibit, in a dose-dependent fashion, the ecdysone 20-monooxygenase activity associated with wandering stage larvae.