Gene Dvir\Adh2

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General Information

Symbol

Dvir\Adh2

Species

D. virilis

Name

Alcohol dehydrogenase 2

Annotation symbol

GJ18209

Feature type

protein_coding_gene

FlyBase ID

FBgn0014837

Gene Model Status

Current

Stock availability

None publicly available

Also Known As

Adh, Adh-2

Genomic Location

Chromosome (arm)

scaffold_12723

Recombination map

Cytogenetic map

Sequence location

scaffold_12723:2,510,385..2,511,267 [+]

Genomic Maps

Summary Information

Automatically generated summary

See sections below for more information

The gene Alcohol dehydrogenase 2 is referred to in FlyBase by the symbol Dvir\Adh2 (GJ18209, FBgn0014837). It is a protein_coding_gene from Drosophila virilis. An electronic pipeline based on InterPro domains suggests that it has the molecular function: alcohol dehydrogenase (NAD) activity; nucleotide binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; alcohol metabolic process. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: Alcohol dehydrogenase, Drosophila-type; Alcohol dehydrogenase, insect-type; NAD(P)-binding domain; Short-chain dehydrogenase/reductase SDR; Short-chain dehydrogenase/reductase, conserved site. Gene sequence location is scaffold_12723:2510385..2511267.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dvir\Adh2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Dvir\Adh2-RA

FBtr0234134

XM_002057548

765

254

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Dvir\Adh2-PA

FBpp0232626

27.6

254

8.22

XP_002057584

EDW57657

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

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Short-chain dehydrogenase/reductase, conserved site (IPR020904)

Alcohol dehydrogenase, insect-type (IPR002424)

Alcohol dehydrogenase, Drosophila-type (IPR002425)

Short-chain dehydrogenase/reductase SDR (IPR002198)

NAD(P)-binding domain (IPR016040)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

B4M8Y0

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Dvir\Adh2	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Dvir\Adh2	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

alcohol dehydrogenase (NAD) activity

inferred from electronic annotation with InterPro:IPR002424, InterPro:IPR002425

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

alcohol metabolic process

inferred from electronic annotation with InterPro:IPR002425

(FlyBase Curators et al., 2004-)

oxidation-reduction process

inferred from electronic annotation with InterPro:IPR002424, InterPro:IPR002425

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

gene

nuclear_gene

(Drosophila 12 Genomes Consortium, 2008)

protein_coding_gene

(Drosophila 12 Genomes Consortium, 2008)

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Dvir\Adh2 allele

Gene

References

External Data

Linkouts

Orthologs

OrthoDB Orthologs (1) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6M39VS

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

EOG6K3JS8

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

EOG68DCPM

Ortholog(s) in Drosophila melanogaster (EOG6M39VS)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Adh

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

Adh activity in 71 Drosophila species is assayed to determine if the protein plays a key role in the adaptation of species to substrates undergoing alcoholic fermentation.

(Mercot et al., 1994)

Quantitative differences in stage- and tissue-specific expression of Dvir\Adh1, Dvir\Adh2, Dtex\Adh, Dame\Adh and Dnov\Adh are observed. These differences seem to correlate with temporal differences in ethanol tolerance among the species. Quantitative differences in protein levels account for most, if not all, of the activity differences among species. Analysis of interspecific hybrids reveals these differences arise by a mechanism affecting monomer synthesis.

(Ranganayakulu and Reddy, 1994)

The in situ localization of Adh transcripts in different species reveals evolved regulatory differences in spatially restricted expression.

(Ranganayakulu, 1994)

Adult acetic acid tolerance found to correlate with ethanol tolerance.

(Chakir et al., 1993)

Interspecific differences in enzyme expression patterns among Hawaiian picture-winged Drosophila and the virilis species group are compared in an effort to understand the forces shaping evolution of regulatory genes and patterns.

(Thorpe et al., 1993)

ADH protein activity and ADH CRM is seen in the testis and hindgut. The level in the hindgut is at least three times the level seen in other species. There are no gross chromosomal rearrangements at adjacent regions of Adh in D.virilis, D.americana.texana, D.novamexicana and D.borealis, so differences in expression are due to regulatory differences. Interspecific hybrids of D.virilis demonstrate that Dvir\Adh2 expression in the testis and hindgut is under cis-dominant control, this cis-acting locus is separable by crossing-over.

(Ranganayakulu et al., 1991)

One of two Adh genes in D.virilis.

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

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