FB2019_05, released Oct 15, 2019

Gene: Dmel\His3.3A

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General Information
Symbol
Dmel\His3.3A
Species
D. melanogaster
Name
Histone H3.3A
Annotation Symbol
CG5825
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014857
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
H3.3, H3.3A, histone H3.3, His3.3, PH3
Key Links
Genomic Location
Cytogenetic map
25C3-25C3
Sequence location
2L:5,055,058..5,056,149 [+]
Recombination map
2-15
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the histone H3 family. (C0HL66)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
structural constituent of chromatin
Predictions / Assertions
DNA binding; protein heterodimerization activity
Summaries
Protein Function (UniProtKB)
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
(UniProt, C0HL66)
Summary (Interactive Fly)
H3 histone subtype - deposition is coupled to transcription and continues while a gene is active - histone replacement suggests a mechanism to maintain both the structure of chromatin and access to DNA at active genes
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\His3.3A or the JBrowse view of Dmel\His3.3A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
His3.3A-RA
FBtr0079010
NM_078755
848
136
His3.3A-RC
FBtr0333536
NM_001273153
926
136
His3.3A-RD
FBtr0333537
NM_164624
772
136
Additional Transcript Data and Comments
Reported size (kB)
0.9 (northern blot)
(Akhmanova et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
His3.3A-PA
FBpp0078649
15.3
136
11.83
NP_523479
AAF52213
His3.3A-PC
FBpp0305716
15.3
136
11.83
NP_001260082
AGB92618
His3.3A-PD
FBpp0305717
15.3
136
11.83
NP_723056
AAN10526
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

136 aa isoforms: His3.3A-PA, His3.3A-PC, His3.3A-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
136 (aa)
(Akhmanova et al., 1995)
Comments
External Data
Subunit Structure (UniProtKB)
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Daxx (via C-terminus) (PubMed:28320872).
(UniProt, C0HL66)
Post Translational Modification
Phosphorylation at Ser-11 by ial/aurora-B during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression. Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome. Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome. Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.
(UniProt, C0HL66)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\His3.3A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
structural constituent of chromatin
inferred from genetic interaction with FLYBASE:His3.3B; FB:FBgn0004828
(Sakai et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
DNA binding
inferred from electronic annotation with InterPro:IPR000164, InterPro:IPR007125
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
non-traceable author statement
(assigned by UniProt )
(Akhmanova et al., 1995)
protein heterodimerization activity
inferred from electronic annotation with InterPro:IPR009072
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
DNA replication-independent nucleosome assembly
inferred from genetic interaction with FLYBASE:His3.3B; FB:FBgn0004828
(Sakai et al., 2009)
male meiotic nuclear division
inferred from genetic interaction with FLYBASE:His3.3B; FB:FBgn0004828
(Sakai et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleosome assembly
non-traceable author statement
(assigned by UniProt )
(Akhmanova et al., 1995)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
nucleosome
inferred from direct assay
(Sakai et al., 2009)
polytene chromosome
inferred from direct assay
(Sakai et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleosome
non-traceable author statement
(assigned by UniProt )
(Akhmanova et al., 1995)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000152093
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
spermatogenesis & adult stage
testis
(Akhmanova et al., 1995)
Additional Descriptive Data
His3.3A is strongly transcribed in the testes.
(Akhmanova et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval salivary gland
(Akhmanova et al., 1997)
spermatogenesis & adult stage
protein body
(Akhmanova et al., 1997)
Y chromosome loop
(Akhmanova et al., 1997)
spermatid
(Akhmanova et al., 1997)
spermatocyte
(Akhmanova et al., 1997)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
Additional Descriptive Data
Antibodies against His3.3 protein stain uniformly over the polytene chromosomes. His3.3 protein staining is seen in meiotic prophase chromatin of primary spermatocytes. One or two strongly staining foci were observed in each nucleus. The distribution of label coincides with the location of some of the Y-chromosomal lampbrush loops. At this stage His3 protein is observed mainly in the autosomal chromatin. In postmeiotic stages, His3.3 protein is observed in the protein body while the His3 protein is found mainly in the chromatin. During spermatid elongation, His3.3 protein is deposited in chromatin. At subsequent stages no major differences were observed in the distribution of His3 protein and His3.3 protein. In post-elongation spermatid cysts, the pattern of staining changes from an even distribution to a dispersed pattern. In mature sperm, no staining is observed.
(Akhmanova et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleosome
inferred from direct assay
(Sakai et al., 2009)
polytene chromosome
inferred from direct assay
(Sakai et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\His3.3A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of His3.3A
Transgenic constructs containing regulatory region of His3.3A
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\H3F3B
10 of 15
Yes
Yes
 
Hsap\HIST1H3F
5 of 15
No
No
 
Hsap\HIST2H3D
5 of 15
No
No
Hsap\H3F3A
4 of 15
No
No
 
Hsap\H3F3C
3 of 15
No
Yes
Hsap\HIST1H3A
3 of 15
No
No
Hsap\HIST1H3B
3 of 15
No
No
 
Hsap\HIST1H3C
3 of 15
No
No
 
Hsap\HIST1H3D
3 of 15
No
No
Hsap\HIST1H3E
3 of 15
No
No
Hsap\HIST1H3H
3 of 15
No
No
 
Hsap\HIST1H3I
3 of 15
No
No
Hsap\HIST1H3J
3 of 15
No
No
Hsap\HIST2H3A
3 of 15
No
No
Hsap\HIST2H3C
3 of 15
No
No
Hsap\HIST3H3
3 of 15
No
Yes
Hsap\HIST1H3G
2 of 15
No
No
Hsap\CENPA
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\H3f3b
10 of 15
Yes
Yes
Mmus\H3f3a
5 of 15
No
Yes
Mmus\Hist1h3a
5 of 15
No
No
Mmus\Hist1h3b
3 of 15
No
No
Mmus\Hist1h3c
3 of 15
No
No
Mmus\Hist1h3d
3 of 15
No
No
Mmus\Hist1h3e
3 of 15
No
No
Mmus\Hist1h3f
3 of 15
No
No
Mmus\Hist1h3g
3 of 15
No
No
Mmus\Hist1h3h
3 of 15
No
No
Mmus\Hist1h3i
3 of 15
No
No
Mmus\Hist2h3b
3 of 15
No
No
Mmus\Hist2h3c1
3 of 15
No
No
Mmus\Hist2h2be
2 of 15
No
No
Mmus\Hist2h3c2
2 of 15
No
No
Mmus\Cenpa
1 of 15
No
No
Mmus\Gm12260
1 of 15
No
Yes
Mmus\Gm12657
1 of 15
No
No
Mmus\H3f3c
1 of 15
No
No
Mmus\LOC105242736
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (18)
Rnor\LOC100361558
9 of 13
Yes
Yes
Rnor\H3f3c
6 of 13
No
Yes
Rnor\H3f3b
4 of 13
No
Yes
Rnor\Hist1h2ail1
3 of 13
No
No
Rnor\Hist1h3a
2 of 13
No
No
Rnor\Hist2h3c2
2 of 13
No
No
Rnor\LOC684762
2 of 13
No
No
Rnor\LOC690126
2 of 13
No
No
Rnor\LOC102549173
2 of 13
No
No
Rnor\RGD1564548
2 of 13
No
Yes
Rnor\Cenpa
1 of 13
No
No
Rnor\Hist3h3
1 of 13
No
No
Rnor\LOC680498
1 of 13
No
No
Rnor\LOC100359421
1 of 13
No
No
Rnor\LOC102548682
1 of 13
No
No
Rnor\LOC108348882
1 of 13
No
Yes
Rnor\LOC108349691
1 of 13
No
Yes
Rnor\RGD1564447
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (34)
Xtro\h3f3b
7 of 12
Yes
Yes
Xtro\h3f3b
4 of 12
No
No
Xtro\hist2h3d
4 of 12
No
Yes
Xtro\h3f3a
3 of 12
No
Yes
Xtro\cenpa
1 of 12
No
No
Xtro\hist1h3g
1 of 12
No
Yes
Xtro\hist2h3c
1 of 12
No
No
Xtro\LOC100485665
1 of 12
No
No
Xtro\LOC100486113
1 of 12
No
No
Xtro\LOC100486653
1 of 12
No
No
Xtro\LOC100486720
1 of 12
No
No
Xtro\LOC100487139
1 of 12
No
No
Xtro\LOC100487179
1 of 12
No
No
Xtro\LOC100487756
1 of 12
No
No
Xtro\LOC100493036
1 of 12
No
No
Xtro\LOC100493041
1 of 12
No
No
Xtro\LOC100493100
1 of 12
No
No
Xtro\LOC100494884
1 of 12
No
No
Xtro\LOC100495338
1 of 12
No
No
Xtro\LOC100495788
1 of 12
No
No
Xtro\LOC100496027
1 of 12
No
No
Xtro\LOC100496129
1 of 12
No
No
Xtro\LOC100497127
1 of 12
No
No
Xtro\LOC100497769
1 of 12
No
No
Xtro\LOC101730642
1 of 12
No
No
Xtro\LOC101730986
1 of 12
No
No
Xtro\LOC101731074
1 of 12
No
No
Xtro\LOC101731144
1 of 12
No
No
Xtro\LOC101732670
1 of 12
No
No
Xtro\LOC105947137
1 of 12
No
No
Xtro\LOC108644516
1 of 12
No
No
Xtro\LOC108646286
1 of 12
No
No
Xtro\LOC108646287
1 of 12
No
No
Xtro\LOC108648869
1 of 12
No
No
Danio rerio (Zebrafish) (20)
Drer\si:ch1073-429i10.3
8 of 15
Yes
Yes
Drer\h3f3a
6 of 15
No
No
Drer\h3f3d
6 of 15
No
Yes
Drer\h3f3b.1
5 of 15
No
Yes
Drer\h3f3c
4 of 15
No
No
Drer\zgc:113983
3 of 15
No
No
Drer\zgc:113984
3 of 15
No
No
Drer\zgc:173552
3 of 15
No
No
Drer\hist2h3ca1
2 of 15
No
No
Drer\hist2h3c
2 of 15
No
No
Drer\LOC108190746
2 of 15
No
No
Drer\LOC108190747
2 of 15
No
No
Drer\selenoh
2 of 15
No
Yes
Drer\si:ch73-36p18.2
2 of 15
No
No
Drer\si:dkey-23a13.8
2 of 15
No
No
Drer\LOC570405
1 of 15
No
Yes
Drer\si:ch211-113a14.27
1 of 15
No
No
Drer\si:ch1073-153i20.2
1 of 15
No
No
Drer\si:dkey-108k21.25
1 of 15
No
No
Drer\si:dkey-261m9.8
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (24)
Cele\his-71
8 of 15
Yes
Yes
Cele\his-2
5 of 15
No
No
Cele\his-69
4 of 15
No
Yes
Cele\his-74
4 of 15
No
No
Cele\his-6
3 of 15
No
No
Cele\his-9
3 of 15
No
No
Cele\his-13
3 of 15
No
No
Cele\his-17
3 of 15
No
No
Cele\his-25
3 of 15
No
No
Cele\his-27
3 of 15
No
No
Cele\his-32
3 of 15
No
No
Cele\his-42
3 of 15
No
No
Cele\his-45
3 of 15
No
No
Cele\his-49
3 of 15
No
No
Cele\his-55
3 of 15
No
No
Cele\his-59
3 of 15
No
No
Cele\his-63
3 of 15
No
No
Cele\his-70
3 of 15
No
Yes
Cele\his-72
3 of 15
No
Yes
Cele\cpar-1
2 of 15
No
No
Cele\F20D6.9
2 of 15
No
Yes
Cele\hcp-3
2 of 15
No
No
Cele\his-40
1 of 15
No
No
Cele\his-73
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (13)
Atha\AT1G09200
5 of 9
Yes
No
Atha\AT1G75600
3 of 9
No
Yes
Atha\AT4G40030
3 of 9
No
Yes
Atha\HTR11
3 of 9
No
No
Atha\AT3G27360
2 of 9
No
No
Atha\AT5G10390
2 of 9
No
No
Atha\AT5G10400
2 of 9
No
No
Atha\AT5G10980
2 of 9
No
No
Atha\AT5G12910
2 of 9
No
Yes
Atha\AT5G65360
2 of 9
No
No
Atha\AT1G13370
1 of 9
No
Yes
Atha\AT4G40040
1 of 9
No
No
Atha\MGH3
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\HHT2
12 of 15
Yes
Yes
Scer\HHT1
6 of 15
No
Yes
Scer\CSE4
1 of 15
No
No
 
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\hht1
10 of 12
Yes
Yes
Spom\hht2
4 of 12
No
Yes
Spom\hht3
4 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190IB2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\His3:CG31613
Drosophila melanogaster
fruit fly
Dmel\His3:CG33824
Drosophila melanogaster
fruit fly
Dmel\His3:CG33803
Drosophila melanogaster
fruit fly
Dmel\His3:CG33860
Drosophila melanogaster
fruit fly
Dmel\His3:CG33842
Drosophila melanogaster
fruit fly
Dmel\His3.3B
Drosophila melanogaster
fruit fly
Dmel\His3:CG33830
Drosophila melanogaster
fruit fly
Dmel\His3:CG33836
Drosophila melanogaster
fruit fly
Dmel\His3:CG33857
Drosophila melanogaster
fruit fly
Dmel\His3:CG33833
Drosophila melanogaster
fruit fly
Dmel\His3:CG33821
Drosophila melanogaster
fruit fly
Dmel\His3.3A
Drosophila melanogaster
fruit fly
Dmel\His3:CG33812
Drosophila melanogaster
fruit fly
Dmel\His3:CG33815
Drosophila melanogaster
fruit fly
Dmel\His3:CG33851
Drosophila melanogaster
fruit fly
Dmel\His3:CG33848
Drosophila melanogaster
fruit fly
Dmel\His3:CG33854
Drosophila melanogaster
fruit fly
Dmel\His3:CG33845
Drosophila melanogaster
fruit fly
Dmel\His3:CG33863
Drosophila melanogaster
fruit fly
Dmel\His3:CG33806
Drosophila melanogaster
fruit fly
Dmel\His3:CG33866
Drosophila melanogaster
fruit fly
Dmel\His3:CG33839
Drosophila melanogaster
fruit fly
Dmel\His3:CG33809
Drosophila melanogaster
fruit fly
Dmel\His3:CG33818
Drosophila melanogaster
fruit fly
Dmel\His3:CG33827
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008899
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005114
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008890
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000265
Drosophila simulans
Dsim\GD28614
Drosophila simulans
Dsim\GD23319
Drosophila simulans
Dsim\GD27984
Drosophila sechellia
Dsec\GM13676
Drosophila sechellia
Dsec\GM18523
Drosophila yakuba
Dyak\His3.3A
Drosophila yakuba
Dyak\GE17412
Drosophila ananassae
Dana\GF15720
Drosophila ananassae
Dana\GF19171
Drosophila ananassae
Dana\GF28200
Drosophila ananassae
Dana\GF20359
Drosophila pseudoobscura pseudoobscura
Dpse\GA32645
Drosophila pseudoobscura pseudoobscura
Dpse\GA22698
Drosophila pseudoobscura pseudoobscura
Dpse\GA19158
Drosophila persimilis
Dper\GL16975
Drosophila persimilis
Dper\GL22373
Drosophila persimilis
Dper\GL23951
Drosophila persimilis
Dper\GL23961
Drosophila persimilis
Dper\GL23955
Drosophila persimilis
Dper\GL26831
Drosophila persimilis
Dper\GL26550
Drosophila persimilis
Dper\GL17801
Drosophila persimilis
Dper\GL23958
Drosophila persimilis
Dper\GL19701
Drosophila willistoni
Dwil\GK23881
Drosophila willistoni
Dwil\GK25162
Drosophila virilis
Dvir\GJ23707
Drosophila virilis
Dvir\GJ17231
Drosophila virilis
Dvir\GJ15308
Drosophila mojavensis
Dmoj\GI14879
Drosophila mojavensis
Dmoj\GI10040
Drosophila mojavensis
Dmoj\GI23446
Drosophila mojavensis
Dmoj\GI16893
Drosophila mojavensis
Dmoj\GI17253
Drosophila mojavensis
Dmoj\GI23442
Drosophila mojavensis
Dmoj\GI11258
Drosophila mojavensis
Dmoj\GI12713
Drosophila mojavensis
Dmoj\GI21876
Drosophila mojavensis
Dmoj\GI16984
Drosophila mojavensis
Dmoj\GI24857
Drosophila grimshawi
Dgri\GH11489
Drosophila grimshawi
Dgri\GH24723
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915091H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007048
Glossina morsitans
Tsetse fly
Gmor\GMOY002746
Glossina morsitans
Tsetse fly
Gmor\GMOY009714
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08806
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11020
Mayetiola destructor
Hessian fly
Mdes\Mdes007234
Mayetiola destructor
Hessian fly
Mdes\Mdes009226
Mayetiola destructor
Hessian fly
Mdes\Mdes016104
Mayetiola destructor
Hessian fly
Mdes\Mdes015934
Mayetiola destructor
Hessian fly
Mdes\Mdes008972
Mayetiola destructor
Hessian fly
Mdes\Mdes003869
Mayetiola destructor
Hessian fly
Mdes\Mdes014439
Mayetiola destructor
Hessian fly
Mdes\Mdes008944
Mayetiola destructor
Hessian fly
Mdes\Mdes016809
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003828
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011424
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003856
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003852
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003850
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003659
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006158
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000492
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003836
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012072
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003827
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000506
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003685
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000482
Anopheles darlingi
American malaria mosquito
Adar\ADAC006124
Anopheles darlingi
American malaria mosquito
Adar\ADAC006365
Anopheles darlingi
American malaria mosquito
Adar\ADAC001855
Anopheles darlingi
American malaria mosquito
Adar\ADAC005675
Anopheles gambiae
Malaria mosquito
Agam\HIS3A
Anopheles gambiae
Malaria mosquito
Agam\AGAP012709
Anopheles gambiae
Malaria mosquito
Agam\AGAP012573
Anopheles gambiae
Malaria mosquito
Agam\AGAP012197
Anopheles gambiae
Malaria mosquito
Agam\AGAP005024
Anopheles gambiae
Malaria mosquito
Agam\AGAP003910
Anopheles gambiae
Malaria mosquito
Agam\AGAP012196
Anopheles gambiae
Malaria mosquito
Agam\AGAP012572
Anopheles gambiae
Malaria mosquito
Agam\AGAP005025
Anopheles gambiae
Malaria mosquito
Agam\AGAP012559
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012398
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012449
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010355
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012420
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015009
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012445
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014759
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012407
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012433
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012453
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010364
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012437
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012429
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012441
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EVE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009648
Bombyx mori
Silkmoth
Bmor\BGIBMGA005550
Danaus plexippus
Monarch butterfly
Dple\DPOGS212517-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207203-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212471-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200276-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008038
Heliconius melpomene
Postman butterfly
Hmel\HMEL000014
Heliconius melpomene
Postman butterfly
Hmel\HMEL009332
Apis florea
Little honeybee
Aflo\2703315764
Apis florea
Little honeybee
Aflo\2309185732
Apis florea
Little honeybee
Aflo\2703315716
Apis florea
Little honeybee
Aflo\2309185764
Apis florea
Little honeybee
Aflo\2208577444
Apis mellifera
Western honey bee
Amel\LOC725272
Apis mellifera
Western honey bee
Amel\LOC725272
Apis mellifera
Western honey bee
Amel\LOC552116
Apis mellifera
Western honey bee
Amel\LOC552116
Apis mellifera
Western honey bee
Amel\LOC725272
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11145
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11144
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22213
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13539
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13419
Bombus terrestris
Buff-tailed bumblebee
Bter\15203933
Bombus terrestris
Buff-tailed bumblebee
Bter\15208993
Bombus terrestris
Buff-tailed bumblebee
Bter\15208995
Bombus terrestris
Buff-tailed bumblebee
Bter\15212252
Bombus terrestris
Buff-tailed bumblebee
Bter\15203937
Linepithema humile
Argentine ant
Lhum\LH24892
Linepithema humile
Argentine ant
Lhum\LH20877
Linepithema humile
Argentine ant
Lhum\LH21967
Linepithema humile
Argentine ant
Lhum\LH21289
Linepithema humile
Argentine ant
Lhum\LH24891
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a38
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001582
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0029a9
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a39
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005050
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008914
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008993
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008913
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG033855
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008645
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016474
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004948
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001064
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004960
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004954
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008995
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG036227
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007695
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG028733
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016479
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004745
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008672
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06588
Tribolium castaneum
Red flour beetle
Tcas\TC031843
Pediculus humanus
Human body louse
Phum\PHUM003560
Pediculus humanus
Human body louse
Phum\PHUM503970
Pediculus humanus
Human body louse
Phum\PHUM492720
Pediculus humanus
Human body louse
Phum\PHUM004150
Pediculus humanus
Human body louse
Phum\PHUM004190
Pediculus humanus
Human body louse
Phum\PHUM504060
Rhodnius prolixus
Kissing bug
Rpro\RPRC008809
Rhodnius prolixus
Kissing bug
Rpro\RPRC014755
Rhodnius prolixus
Kissing bug
Rpro\RPRC014641
Rhodnius prolixus
Kissing bug
Rpro\RPRC009024
Rhodnius prolixus
Kissing bug
Rpro\RPRC005821
Rhodnius prolixus
Kissing bug
Rpro\RPRC000325
Cimex lectularius
Bed bug
Clec\CLEC006298
Cimex lectularius
Bed bug
Clec\CLEC025014
Cimex lectularius
Bed bug
Clec\CLEC008769
Cimex lectularius
Bed bug
Clec\CLEC025203
Cimex lectularius
Bed bug
Clec\CLEC025059
Cimex lectularius
Bed bug
Clec\CLEC025200
Cimex lectularius
Bed bug
Clec\CLEC002560
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI082116
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000605
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007201
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI082897
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085787
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007201
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007201
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086174
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007201
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04751
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13806
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15314
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0I1I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006373
Strigamia maritima
European centipede
Smar\SMAR006372
Strigamia maritima
European centipede
Smar\SMAR000116
Strigamia maritima
European centipede
Smar\SMAR013626
Ixodes scapularis
Black-legged tick
Isca\ISCW003178
Ixodes scapularis
Black-legged tick
Isca\ISCW002300
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81878.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77247.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67991.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g02800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g07250
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g01530
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g07300
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43602
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_255862
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44149
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44125
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44115
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43862
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43482
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43440
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_235802
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44116
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_235620
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43597
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43863
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_67712
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43874
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_120923
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44153
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_189533
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43405
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_235594
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43402
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44114
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302027
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43467
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_231307
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_330237
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304645
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43441
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_246214
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_235586
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0XGD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_25
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_30
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_61
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_36
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_28
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_56
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH3b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_39
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_32
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh4c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-ClvhH2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_19
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_26
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_53
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_39
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_60
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_011384gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2ag
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh4e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_21
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_22
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_25
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unk_40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_38
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2ah
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_41
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_35
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_14
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bg
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_38
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_38
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_57
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2ae
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-HH3.3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_36
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_15
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_62
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_17
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_35
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CshH3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_46
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_58
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH3h
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_56
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_44
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_20
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_30
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_19
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023416gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH3f
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_41
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_67
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_23
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_65
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_50
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_27
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_78
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_41
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_73
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_21
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_68
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_82
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003047gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_66
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_19
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_58
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_53
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_19
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bd
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_55
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_47
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_014879gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_25
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2af
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_025973gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh3a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_32
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bi
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_69
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_27
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_23
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_34
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_45
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH4b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_44
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_75
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_63
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_34
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_26
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_14
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_76
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_20
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2aj
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2aa
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2ac
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_47
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_51
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_70
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_17
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SphH2b2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-HmH2a.1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_69
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_31
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2ba
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_18
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_53
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_50
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SphH2b1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_49
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_60
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_37
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH3c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_59
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_62
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_20
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh4f
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_77
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003064gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_79
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_55
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_28
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-ClvhH4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_14
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_31
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_21
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_64
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH3e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-ClvhH2a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_39
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_54
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_52
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh4a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_25
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH3g
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_39
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_54
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_21
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_45
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_59
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-HH2az
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_43
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh4g
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_52
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_33
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_59
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LhH1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2be
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_33
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_64
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_56
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_43
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_68
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_45
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_57
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_63
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_49
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_76
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_61
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_30
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_27
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_20
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_17
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_34
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_33
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_008231gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_36
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_74
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_32
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_67
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_24
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_37
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_66
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_51
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unk_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_48
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_37
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_58
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2b_38
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_31
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bj
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_22
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_24
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-HmH2a.2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_46
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH3_49
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_65
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_47
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_48
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_54
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lhh2bc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_81
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH1_31
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH2a_18
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EhH4_72
Ciona intestinalis
Vase tunicate
Cint\LOC100175631
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001161
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021197
Ciona intestinalis
Vase tunicate
Cint\LOC100183235
Ciona intestinalis
Vase tunicate
Cint\LOC100186757
Ciona intestinalis
Vase tunicate
Cint\LOC100183843
Gallus gallus
Domestic chicken
Ggal\LOC418707
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004794
Gallus gallus
Domestic chicken
Ggal\LOC427896
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028417
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027888
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027064
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025786
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028372
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027571
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027174
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000020078
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027594
Gallus gallus
Domestic chicken
Ggal\H2B-V
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027257
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000024338
Gallus gallus
Domestic chicken
Ggal\LOC429558
Gallus gallus
Domestic chicken
Ggal\H2AFZ
Gallus gallus
Domestic chicken
Ggal\LOC426037
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000011759
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026738
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026449
Gallus gallus
Domestic chicken
Ggal\HIST1H2AH
Gallus gallus
Domestic chicken
Ggal\H2AFV
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025711
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000002286
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027113
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006360
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027315
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027425
Gallus gallus
Domestic chicken
Ggal\LOC427882
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (25)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
His3:CG33848
7 of 10
His3.3B
5 of 10
His3:CG31613
4 of 10
His3:CG33803
4 of 10
His3:CG33806
4 of 10
His3:CG33809
4 of 10
His3:CG33812
4 of 10
His3:CG33815
4 of 10
His3:CG33818
4 of 10
His3:CG33821
4 of 10
His3:CG33824
4 of 10
His3:CG33827
4 of 10
His3:CG33830
4 of 10
His3:CG33833
4 of 10
His3:CG33836
4 of 10
His3:CG33839
4 of 10
His3:CG33842
4 of 10
His3:CG33845
4 of 10
His3:CG33851
4 of 10
His3:CG33854
4 of 10
His3:CG33857
4 of 10
His3:CG33860
4 of 10
His3:CG33863
4 of 10
His3:CG33866
4 of 10
cid
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    H3-3B; H3.3 histone B
    10 of 15
    601058
         
        H3C7; H3 clustered histone 7
        5 of 15
        602816
             
            H3C13; H3 clustered histone 13
            5 of 15
                H3-3A; H3.3 histone A
                4 of 15
                601128
                     
                    H3-5; H3.5 histone
                    3 of 15
                    616134
                        H3C1; H3 clustered histone 1
                        3 of 15
                        602810
                            H3C2; H3 clustered histone 2
                            3 of 15
                            602819
                                 
                                H3C3; H3 clustered histone 3
                                3 of 15
                                602812
                                     
                                    H3C4; H3 clustered histone 4
                                    3 of 15
                                    602811
                                        H3C6; H3 clustered histone 6
                                        3 of 15
                                        602813
                                            H3C10; H3 clustered histone 10
                                            3 of 15
                                            602818
                                                 
                                                H3C11; H3 clustered histone 11
                                                3 of 15
                                                602814
                                                    H3C12; H3 clustered histone 12
                                                    3 of 15
                                                    602817
                                                        H3C15; H3 clustered histone 15
                                                        3 of 15
                                                            H3C14; H3 clustered histone 14
                                                            3 of 15
                                                            142780
                                                                H3-4; H3.4 histone
                                                                3 of 15
                                                                602820
                                                                    Functional Complementation Data
                                                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                    Interactions
                                                                    Summary of Physical Interactions
                                                                    Summary of Genetic Interactions
                                                                    esyN Network Diagram
                                                                    esyN Network Key:
                                                                    Suppression
                                                                    Enhancement
                                                                    View in Interactions Browser
                                                                    Please look at the allele data for full details of the genetic interactions
                                                                    Starting gene(s)
                                                                    Interaction type
                                                                    Interacting gene(s)
                                                                    Reference
                                                                    His3.3A|His3.3B
                                                                    suppressible
                                                                    His3
                                                                    (Hödl and Basler, 2012)
                                                                    Starting gene(s)
                                                                    Interaction type
                                                                    Interacting gene(s)
                                                                    Reference
                                                                    External Data
                                                                    Subunit Structure (UniProtKB)
                                                                    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Daxx (via C-terminus) (PubMed:28320872).
                                                                    (UniProt, C0HL66 )
                                                                    Linkouts
                                                                    BioGRID - A database of protein and genetic interactions.
                                                                    DroID - A comprehensive database of gene and protein interactions.
                                                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                    Pathways
                                                                    Genomic Location and Detailed Mapping Data
                                                                    Chromosome (arm)
                                                                    2L
                                                                    Recombination map
                                                                    2-15
                                                                    Cytogenetic map
                                                                    25C3-25C3
                                                                    Sequence location
                                                                    2L:5,055,058..5,056,149 [+]
                                                                    FlyBase Computed Cytological Location
                                                                    Cytogenetic map
                                                                    Evidence for location
                                                                    25C3-25C3
                                                                    Limits computationally determined from genome sequence between P{lacW}vkgk16721&P{lacW}Cg25Ck00405 and P{lacW}l(2)k11206k11206
                                                                    Experimentally Determined Cytological Location
                                                                    Cytogenetic map
                                                                    Notes
                                                                    References
                                                                    Experimentally Determined Recombination Data
                                                                    Location
                                                                    2-15
                                                                    (FlyBase, 2016)
                                                                    2-16.5
                                                                    (Comeron et al., 2012)
                                                                    2-
                                                                    Left of (cM)
                                                                    Right of (cM)
                                                                    Notes
                                                                    Stocks and Reagents
                                                                    Stocks (8)
                                                                    Genomic Clones (12)
                                                                     

                                                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                    cDNA Clones (208)
                                                                     

                                                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                    cDNA clones, fully sequences
                                                                    BDGP DGC clones
                                                                    Other clones
                                                                      Drosophila Genomics Resource Center cDNA clones

                                                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                      cDNA Clones, End Sequenced (ESTs)
                                                                      BDGP DGC clones
                                                                      Other clones
                                                                      RNAi and Array Information
                                                                      Linkouts
                                                                      DRSC - Results frm RNAi screens
                                                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                                      Antibody Information
                                                                      Laboratory Generated Antibodies
                                                                       
                                                                      polyclonal
                                                                      (Akhmanova et al., 1997)
                                                                      Commercially Available Antibodies
                                                                       
                                                                      Other Information
                                                                      Relationship to Other Genes
                                                                      Source for database identify of
                                                                      Source for database merge of
                                                                      Additional comments
                                                                      Other Comments
                                                                      The canonical "H3.2" histone (His3, present in multiple copies in the genome as part of the repeating histone gene unit) and variant "His3.3" histone (encoded by His3.3A and His3.3B) forms can functionally replace each other. Cells are able to divide and differentiate when H3.2 is entirely absent but is replaced by S phase-expressed His3.3.
                                                                      (Hödl and Basler, 2012)
                                                                      Cells that contain a non-methylatable residue instead of K4 in all canonical and variant H3 genes are competent to respond to major developmental signaling pathways by activating target gene expression, although their proliferative capacity is slowed down relative to wild type.
                                                                      (Hödl and Basler, 2012)
                                                                      Nucleosomes containing His3.3A protein but not His3 protein are specifically assembled in paternal chromatin before the first round of DNA replication in the fertilised egg.
                                                                      (Loppin et al., 2005)
                                                                      RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
                                                                      (Boutros et al., 2004)
                                                                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                                                                      (Kiger et al., 2003)
                                                                      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cells become round and detached.
                                                                      (Kiger et al., 2003)
                                                                      Replication independent deposition of His3.3A occurs at particular loci, including active rDNA arrays.
                                                                      (Ahmad and Henikoff, 2002)
                                                                      His3.3A has been cloned and sequenced.
                                                                      (Akhmanova et al., 1995)
                                                                      The histone H3.3 replacement variant is encoded by two genes, His3.3A and His3.3B, in D.melanogaster. These genes encode exactly the same protein but are widely divergent in their untranslated regions.
                                                                      (Akhmanova et al., 1995)
                                                                      Origin and Etymology
                                                                      Discoverer
                                                                      Etymology
                                                                      Identification
                                                                      External Crossreferences and Linkouts ( 65 )
                                                                      Sequence Crossreferences
                                                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                      Other crossreferences
                                                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                      Flygut - An atlas of the Drosophila adult midgut
                                                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                      InterPro - A database of protein families, domains and functional sites
                                                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                      modMine - A data warehouse for the modENCODE project
                                                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                      Linkouts
                                                                      BioGRID - A database of protein and genetic interactions.
                                                                      DroID - A comprehensive database of gene and protein interactions.
                                                                      DRSC - Results frm RNAi screens
                                                                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                      FlyMine - An integrated database for Drosophila genomics
                                                                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                      Synonyms and Secondary IDs (15)
                                                                      Reported As
                                                                      Symbol Synonym
                                                                      CG5825
                                                                      (Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wagner et al., 2007)
                                                                      H3.3
                                                                      (Fromental-Ramain et al., 2017, Shih et al., 2016, Horard and Loppin, 2015, Vlijm et al., 2015, Li and Zhou, 2013, Orsi et al., 2013, Ito et al., 2012, Nakayama et al., 2012, Tran et al., 2012, Szenker et al., 2011, Deal et al., 2010, Guertin and Lis, 2010, Macalpine et al., 2010, modENCODE Consortium et al., 2010, Sawatsubashi et al., 2010, van Steensel et al., 2010, Braunschweig et al., 2009, Henikoff et al., 2009, Schneiderman et al., 2009, Doheny et al., 2008, Schneiderman and Ahmad, 2008, Bell et al., 2007, Bonnefoy et al., 2007, de Wit et al., 2007, Konev et al., 2007, Konev et al., 2007, Li et al., 2007, Mito et al., 2007, Nakayama et al., 2007, Pinnola et al., 2007, Rathke et al., 2007, Ellis, 2006, Graves and Tamkun, 2006, Moorman et al., 2006, Orian, 2006, Polo and Almouzni, 2006, Spradling, 2006, Jin, 2005, Loppin et al., 2005, Mito et al., 2005, Schwartz and Ahmad, 2005, Zhou, 2005, Heinkoff et al., 2004, McKittrick et al., 2004, McKittrick et al., 2004, Schwartz and Ahmad, 2004, Fahrner and Baylin, 2003, Hennig, 2003, Ahmad and Henikoff, 2002, Ahmad and Henikoff, 2002, Goll and Bestor, 2002, Akhmanova et al., 1997, Akhmanova et al., 1995)
                                                                      H3.3A
                                                                      (Leatham-Jensen et al., 2019, Shindo and Amodeo, 2019, Penke et al., 2018, Chen et al., 2015, Rathke et al., 2014, Shevelyov et al., 2009, Doheny et al., 2008, Wagner et al., 2007, Feng et al., 2005)
                                                                      His-3.3A
                                                                      (Shevelyov et al., 2009)
                                                                      His3.3
                                                                      (Cavalli, 2006, Kamakaka and Biggins, 2005, Lippman and Martienssen, 2004)
                                                                      His3.3A
                                                                      (Dorafshan et al., 2019, Song et al., 2018, Jambor et al., 2015, Handler et al., 2013, Hödl and Basler, 2012, Japanese National Institute of Genetics, 2012.5.21, Schneiderman et al., 2012, Mourikis et al., 2010, Hödl and Basler, 2009, Sakai et al., 2009, de Wit et al., 2008, Dorus et al., 2006, Stanyon et al., 2004)
                                                                      PH3
                                                                      (Whittaker et al., 2000, Su et al., 1999)
                                                                      dH3.3A
                                                                      (Wagner et al., 2007)
                                                                      Name Synonyms
                                                                      H3L-like histone
                                                                      (Mancini, 2003.9.9)
                                                                      Histone H3.3A
                                                                      (Doheny et al., 2008)
                                                                      histone H3.3
                                                                      (Rathke et al., 2007, Ringrose and Paro, 2007, Mito et al., 2005, Wirbelauer et al., 2005)
                                                                      histone H3.3 variant
                                                                      (Bonnefoy et al., 2007)
                                                                      histone H3.3A
                                                                      (Bindels, 1994.10.20)
                                                                      histone variant 3.3
                                                                      (Ellis, 2006)
                                                                      histone variant H3.3
                                                                      (Zhou, 2005)
                                                                      Secondary FlyBase IDs
                                                                        Datasets (0)
                                                                        Study focus (0)
                                                                        Experimental Role
                                                                        Project
                                                                        Project Type
                                                                        Title
                                                                        References (118)