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Gene Dmel\His3.3A

General Information
Symbol	Dmel\His3.3A	Species	D. melanogaster
Name	Histone H3.3A	Annotation symbol	CG5825
Feature type	protein_coding_gene	FlyBase ID	FBgn0014857
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	H3.3, H3.3A, His3.3, PH3
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	25C3-25C3	Sequence location	2L:5,055,058..5,055,995 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Histone H3.3A is referred to in FlyBase by the symbol Dmel\His3.3A (CG5825, FBgn0014857). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; cell adhesion; male meiosis. 27 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Histone H3; Histone core; Histone-fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval/adult Malpighian tubules, larval fat body, adult spermathecae, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627685_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of His3.3A. Gene sequence location is 2L:5055058..5055995.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA03343 BKN31754 References Guertin and Lis, 2010, PLoS Genet. 6(9):
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25C3-25C3   Limits computationally determined from genome sequence between P{lacW}vkgk16721&P{lacW}Cg25Ck00405 and P{lacW}l(2)k11206k11206
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\His3.3A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) His3.3A-RA FBtr0079010  NM_078755   848   136 His3.3A-RB FBtr0079011  NM_164624   799   123
Additional Transcript Data & Comments
Reported size (kB)	0.9 (northern blot) (Akhmanova et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein His3.3A-PA   FBpp0078649   15.3   136   11.83     NP_523479   AAF52213 His3.3A-PB   FBpp0078650   13.6   123   11.34     NP_723056   AAN10526
Additional Polypeptide Data & Comments
Reported size (kDa)	136 (aa) (Akhmanova et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histone H3 (IPR000164) Histone core (IPR007125) Histone-fold (IPR009072)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA941417   AA950707   AE014134 AAF52213   AE014134 AAN10526   AI109177   AI292982   AI513654   AI945449   AK340415   AK342236   AY071057 AAL48679   AY118325   AY119629 AAM50283   AY231774   AY383571 AAQ96278   BF493569   BF503179   BG633632   BG633664   BG661100   BH615067   BI168895   BI171873   BI172070   BI215264   BI230519   BI234136   BI237087   BI237100   BI242203   BI242724   BI243949   BI354005   BI355073   BI358012   BI358031   BI358543   BI365321   BI367125   BI367390   BI368531   BI368604   BI370185   BI374023   BI376141   BI483140   BI484313   BI485196   BI485837   BI563443   BI563981   BI564290   BI565698   BI565903   BI565965   BI566946   BI566951   BI571577   BI571900   BI572110   BI572516   BI572554   BI574169   BI574388   BI574985   BI575804   BI576485   BI576967   BI577244   BI580561   BI583301   BI585941   BI586313   BI586618   BI586879   BI587000   BI587370   BI587405   BI587410   BI587467   BI587564   BI587597   BI588156   BI588521   BI590947   BI591078   BI591083   BI591587   BI592090   BI606046   BI609230   BI611148   BI613242   BI613924   BI615136   BI615876   BI616383   BI618205   BI618315   BI621036   BI621329   BI622127   BI622690   BI622793   BI623092   BI623875   BI628472   BI629878   BI630709   BI631874   BI634220   BI636785   BI640696   BP549227   BP549587   BP550645   BP550646   BP554549   BP554550   BP559985   BP559986   CO191906   CO193106   CO269867   CO336315   DQ443228   DQ445518   EC208756   EC263249   GH941742   GH943236   GH945182   GH945678   GH947323   GH947436   GH947552   GH947803   GH947862   GH947907   GH948044   GH948353   GH948802   GH949089   GH949255   GH949873   GH950170   GH950360   GH950468   GH951583   GH952302   GH952314   GH952708   GH953233   GH953433   GH953576   GH953631   GH953711   GH953847   GH954209   GH954927   GH955948   GH956095   GH956461   GH956634   GH957043   GH957397   GH957425   GH957534   GH957603   GH958410   GH958843   GH958881   GH959421   GH959514   GH959903   GH960337   GH960474   GH960645   GH962274   GH963330   GH963428   GH964671   GH965203   GH965236   GH965324   GH965503   GH965786   GH967260   GH968972   GH969240   GH969284   GH969514   GH969700   GH969989   GH971036   GH971389   GH971462   GH971508   GH971875   GH973626   GH974042   GH974171   GH974207   GH974328   GH974856   GH974927   GH975447   GH976333   GH976467   GH976553   GH976740   GH976938   GH977221   GH977239   GH977539   GH979045   GH979818   GH980234   GH980603   GH982282   GH982488   GH984260   GH984604   X82257 CAA57712
UniProtKB/Swiss-Prot	P84249
UniProtKB/TrEMBL	Q6TXQ1 E2QCP0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference spermatogenesis & adult stage   testis   (Akhmanova et al., 1995)
Additional Descriptive Data
	His3.3A is strongly transcribed in the testes. (Akhmanova et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval salivary gland   • polytene chromosome (Akhmanova et al., 1997) spermatogenesis & adult stage   protein body   (Akhmanova et al., 1997) Y chromosome loop   (Akhmanova et al., 1997) spermatid   (Akhmanova et al., 1997) spermatocyte   (Akhmanova et al., 1997) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006)
Additional Descriptive Data
	Antibodies against His3.3 protein stain uniformly over the polytene chromosomes. His3.3 protein staining is seen in meiotic prophase chromatin of primary spermatocytes. One or two strongly staining foci were observed in each nucleus. The distribution of label coincides with the location of some of the Y-chromosomal lampbrush loops. At this stage His3 protein is observed mainly in the autosomal chromatin. In postmeiotic stages, His3.3 protein is observed in the protein body while the His3 protein is found mainly in the chromatin. During spermatid elongation, His3.3 protein is deposited in chromatin. At subsequent stages no major differences were observed in the distribution of His3 protein and His3.3 protein. In post-elongation spermatid cysts, the pattern of staining changes from an even distribution to a dispersed pattern. In mature sperm, no staining is observed. (Akhmanova et al., 1997)
Marker for
Subcellular Localization
CV Term	first meiotic prophase (Akhmanova et al., 1997)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0014857    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0014857 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0014857 expression level Developmental Stage   Expression Level embryo 00-02hr    16114 embryo 02-04hr    37338 embryo 04-06hr    53905 embryo 06-08hr    69180 embryo 08-10hr    57959 embryo 10-12hr    52365 embryo 12-14hr    23545 embryo 14-16hr    27075 embryo 16-18hr    17590 embryo 18-20hr    15107 embryo 20-22hr    9810 embryo 22-24hr    7659 larva L1    6788 larva L2    9150 larva L3 12hr old    6954 larva L3 puffstage 1-2    9634 larva L3 puffstage 3-6    12176 larva L3 puffstage 7-9    11215 white prepupae new    9590 white prepupae 12hr    10330 white prepupae 24hr    13040 pupae 2d postWPP    7417 pupae 3d postWPP    4853 pupae 4d postWPP    6523 adult male 01day    7985 adult male 05day    11328 adult male 30day    11533 adult female 01day    9923 adult female 05day    9135 adult female 30day    10983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16114) embryo 02-04hr  (37338) embryo 04-06hr  (53905) embryo 06-08hr  (69180) embryo 08-10hr  (57959) embryo 10-12hr  (52365) embryo 12-14hr  (23545) embryo 14-16hr  (27075) embryo 16-18hr  (17590) embryo 18-20hr  (15107) embryo 20-22hr  (9810) embryo 22-24hr  (7659) larva L1  (6788) larva L2  (9150) larva L3 12hr old  (6954) larva L3 puffstage 1-2  (9634) larva L3 puffstage 3-6  (12176) larva L3 puffstage 7-9  (11215) white prepupae new  (9590) white prepupae 12hr  (10330) white prepupae 24hr  (13040) pupae 2d postWPP  (7417) pupae 3d postWPP  (4853) pupae 4d postWPP  (6523) adult male 01day  (7985) adult male 05day  (11328) adult male 30day  (11533) adult female 01day  (9923) adult female 05day  (9135) adult female 30day  (10983) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16114) embryo 02-04hr  (37338) embryo 04-06hr  (53905) embryo 06-08hr  (69180) embryo 08-10hr  (57959) embryo 10-12hr  (52365) embryo 12-14hr  (23545) embryo 14-16hr  (27075) embryo 16-18hr  (17590) embryo 18-20hr  (15107) embryo 20-22hr  (9810) embryo 22-24hr  (7659) larva L1  (6788) larva L2  (9150) larva L3 12hr old  (6954) larva L3 puffstage 1-2  (9634) larva L3 puffstage 3-6  (12176) larva L3 puffstage 7-9  (11215) white prepupae new  (9590) white prepupae 12hr  (10330) white prepupae 24hr  (13040) pupae 2d postWPP  (7417) pupae 3d postWPP  (4853) pupae 4d postWPP  (6523) adult male 01day  (7985) adult male 05day  (11328) adult male 30day  (11533) adult female 01day  (9923) adult female 05day  (9135) adult female 30day  (10983) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (16114) embryo 02-04hr  (37338) embryo 04-06hr  (53905) embryo 06-08hr  (69180) embryo 08-10hr  (57959) embryo 10-12hr  (52365) embryo 12-14hr  (23545) embryo 14-16hr  (27075) embryo 16-18hr  (17590) embryo 18-20hr  (15107) embryo 20-22hr    9810 embryo 22-24hr    7659 larva L1    6788 larva L2    9150 larva L3 12hr old    6954 larva L3 puffstage 1-2    9634 larva L3 puffstage 3-6  (12176) larva L3 puffstage 7-9  (11215) white prepupae new    9590 white prepupae 12hr  10330 white prepupae 24hr  (13040) pupae 2d postWPP    7417 pupae 3d postWPP    4853 pupae 4d postWPP    6523 adult male 01day    7985 adult male 05day  (11328) adult male 30day  (11533) adult female 01day    9923 adult female 05day    9135 adult female 30day  (10983) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16114 embryo 02-04hr    37338 embryo 04-06hr    53905 embryo 06-08hr    69180 embryo 08-10hr    57959 embryo 10-12hr    52365 embryo 12-14hr    23545 embryo 14-16hr    27075 embryo 16-18hr    17590 embryo 18-20hr    15107 embryo 20-22hr    9810 embryo 22-24hr    7659 larva L1    6788 larva L2    9150 larva L3 12hr old    6954 larva L3 puffstage 1-2    9634 larva L3 puffstage 3-6    12176 larva L3 puffstage 7-9    11215 white prepupae new    9590 white prepupae 12hr    10330 white prepupae 24hr    13040 pupae 2d postWPP    7417 pupae 3d postWPP    4853 pupae 4d postWPP    6523 adult male 01day    7985 adult male 05day    11328 adult male 30day    11533 adult female 01day    9923 adult female 05day    9135 adult female 30day    10983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0014857 expression level Developmental Stage   Expression Level embryo 00-02hr    16114 embryo 02-04hr    37338 embryo 04-06hr    53905 embryo 06-08hr    69180 embryo 08-10hr    57959 embryo 10-12hr    52365 embryo 12-14hr    23545 embryo 14-16hr    27075 embryo 16-18hr    17590 embryo 18-20hr    15107 embryo 20-22hr    9810 embryo 22-24hr    7659 larva L1    6788 larva L2    9150 larva L3 12hr old    6954 larva L3 puffstage 1-2    9634 larva L3 puffstage 3-6    12176 larva L3 puffstage 7-9    11215 white prepupae new    9590 white prepupae 12hr    10330 white prepupae 24hr    13040 pupae 2d postWPP    7417 pupae 3d postWPP    4853 pupae 4d postWPP    6523 adult male 01day    7985 adult male 05day    11328 adult male 30day    11533 adult female 01day    9923 adult female 05day    9135 adult female 30day    10983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16114) embryo 02-04hr  (37338) embryo 04-06hr  (53905) embryo 06-08hr  (69180) embryo 08-10hr  (57959) embryo 10-12hr  (52365) embryo 12-14hr  (23545) embryo 14-16hr  (27075) embryo 16-18hr  (17590) embryo 18-20hr  (15107) embryo 20-22hr  (9810) embryo 22-24hr  (7659) larva L1  (6788) larva L2  (9150) larva L3 12hr old  (6954) larva L3 puffstage 1-2  (9634) larva L3 puffstage 3-6  (12176) larva L3 puffstage 7-9  (11215) white prepupae new  (9590) white prepupae 12hr  (10330) white prepupae 24hr  (13040) pupae 2d postWPP  (7417) pupae 3d postWPP  (4853) pupae 4d postWPP  (6523) adult male 01day  (7985) adult male 05day  (11328) adult male 30day  (11533) adult female 01day  (9923) adult female 05day  (9135) adult female 30day  (10983) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16114) embryo 02-04hr  (37338) embryo 04-06hr  (53905) embryo 06-08hr  (69180) embryo 08-10hr  (57959) embryo 10-12hr  (52365) embryo 12-14hr  (23545) embryo 14-16hr  (27075) embryo 16-18hr  (17590) embryo 18-20hr  (15107) embryo 20-22hr  (9810) embryo 22-24hr  (7659) larva L1  (6788) larva L2  (9150) larva L3 12hr old  (6954) larva L3 puffstage 1-2  (9634) larva L3 puffstage 3-6  (12176) larva L3 puffstage 7-9  (11215) white prepupae new  (9590) white prepupae 12hr  (10330) white prepupae 24hr  (13040) pupae 2d postWPP  (7417) pupae 3d postWPP  (4853) pupae 4d postWPP  (6523) adult male 01day  (7985) adult male 05day  (11328) adult male 30day  (11533) adult female 01day  (9923) adult female 05day  (9135) adult female 30day  (10983) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  16114 embryo 02-04hr  (37338) embryo 04-06hr  (53905) embryo 06-08hr  (69180) embryo 08-10hr  (57959) embryo 10-12hr  (52365) embryo 12-14hr  (23545) embryo 14-16hr  (27075) embryo 16-18hr  17590 embryo 18-20hr  15107 embryo 20-22hr    9810 embryo 22-24hr    7659 larva L1    6788 larva L2    9150 larva L3 12hr old    6954 larva L3 puffstage 1-2    9634 larva L3 puffstage 3-6  12176 larva L3 puffstage 7-9  11215 white prepupae new    9590 white prepupae 12hr  10330 white prepupae 24hr  13040 pupae 2d postWPP    7417 pupae 3d postWPP    4853 pupae 4d postWPP    6523 adult male 01day    7985 adult male 05day  11328 adult male 30day  11533 adult female 01day    9923 adult female 05day    9135 adult female 30day  10983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16114 embryo 02-04hr    37338 embryo 04-06hr    53905 embryo 06-08hr    69180 embryo 08-10hr    57959 embryo 10-12hr    52365 embryo 12-14hr    23545 embryo 14-16hr    27075 embryo 16-18hr    17590 embryo 18-20hr    15107 embryo 20-22hr    9810 embryo 22-24hr    7659 larva L1    6788 larva L2    9150 larva L3 12hr old    6954 larva L3 puffstage 1-2    9634 larva L3 puffstage 3-6    12176 larva L3 puffstage 7-9    11215 white prepupae new    9590 white prepupae 12hr    10330 white prepupae 24hr    13040 pupae 2d postWPP    7417 pupae 3d postWPP    4853 pupae 4d postWPP    6523 adult male 01day    7985 adult male 05day    11328 adult male 30day    11533 adult female 01day    9923 adult female 05day    9135 adult female 30day    10983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0014857    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0014857 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval/adult Malpighian tubules, larval fat body, adult spermathecae, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0014857 expression level Tissue   Expression Level Larval Central Nervous System    1625.225 Larval Midgut    636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland    1122.9 Larval Trachea    767.6 Larval Carcass    445.5 Adult Head    767.4 Adult Eye    1533.75 Adult Brain    636 Adult Thoracic-Abdominal Ganglion    578.5 Adult Crop    504.3 Adult Midgut    1499.7 Adult Hindgut    786.9 Adult Malpighian Tubules    135.7 Adult Fat Body    607.8 Adult Salivary Gland    1907.7 Adult Heart    711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary    579.8 Adult Testis    460.1 Adult Male Accessory Gland    503.7 Adult Carcass    643.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1625.225) Larval Midgut  (636) Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland  (1122.9) Larval Trachea  (767.6) Larval Carcass    445.5 Adult Head  (767.4) Adult Eye  (1533.75) Adult Brain  (636) Adult Thoracic-Abdominal Ganglion  (578.5) Adult Crop  504.3 Adult Midgut  (1499.7) Adult Hindgut  (786.9) Adult Malpighian Tubules    135.7 Adult Fat Body  (607.8) Adult Salivary Gland  (1907.7) Adult Heart  (711.725) Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary  (579.8) Adult Testis    460.1 Adult Male Accessory Gland  503.7 Adult Carcass  (643.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1625.225) Larval Midgut    636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland  (1122.9) Larval Trachea    767.6 Larval Carcass    445.5 Adult Head    767.4 Adult Eye  (1533.75) Adult Brain    636 Adult Thoracic-Abdominal Ganglion    578.5 Adult Crop    504.3 Adult Midgut  (1499.7) Adult Hindgut    786.9 Adult Malpighian Tubules    135.7 Adult Fat Body    607.8 Adult Salivary Gland  (1907.7) Adult Heart    711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary    579.8 Adult Testis    460.1 Adult Male Accessory Gland    503.7 Adult Carcass    643.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1625.225 Larval Midgut    636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland    1122.9 Larval Trachea    767.6 Larval Carcass    445.5 Adult Head    767.4 Adult Eye    1533.75 Adult Brain    636 Adult Thoracic-Abdominal Ganglion    578.5 Adult Crop    504.3 Adult Midgut    1499.7 Adult Hindgut    786.9 Adult Malpighian Tubules    135.7 Adult Fat Body    607.8 Adult Salivary Gland    1907.7 Adult Heart    711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary    579.8 Adult Testis    460.1 Adult Male Accessory Gland    503.7 Adult Carcass    643.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0014857 expression level Tissue   Expression Level Larval Central Nervous System    1625.225 Larval Midgut    636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland    1122.9 Larval Trachea    767.6 Larval Carcass    445.5 Adult Head    767.4 Adult Eye    1533.75 Adult Brain    636 Adult Thoracic-Abdominal Ganglion    578.5 Adult Crop    504.3 Adult Midgut    1499.7 Adult Hindgut    786.9 Adult Malpighian Tubules    135.7 Adult Fat Body    607.8 Adult Salivary Gland    1907.7 Adult Heart    711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary    579.8 Adult Testis    460.1 Adult Male Accessory Gland    503.7 Adult Carcass    643.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1625.225) Larval Midgut  636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland  (1122.9) Larval Trachea  767.6 Larval Carcass    445.5 Adult Head  767.4 Adult Eye  (1533.75) Adult Brain  636 Adult Thoracic-Abdominal Ganglion  578.5 Adult Crop  504.3 Adult Midgut  (1499.7) Adult Hindgut  786.9 Adult Malpighian Tubules    135.7 Adult Fat Body  607.8 Adult Salivary Gland  (1907.7) Adult Heart  711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary  579.8 Adult Testis    460.1 Adult Male Accessory Gland  503.7 Adult Carcass  643.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1625.225 Larval Midgut    636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland  1122.9 Larval Trachea    767.6 Larval Carcass    445.5 Adult Head    767.4 Adult Eye  1533.75 Adult Brain    636 Adult Thoracic-Abdominal Ganglion    578.5 Adult Crop    504.3 Adult Midgut  1499.7 Adult Hindgut    786.9 Adult Malpighian Tubules    135.7 Adult Fat Body    607.8 Adult Salivary Gland  (1907.7) Adult Heart    711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary    579.8 Adult Testis    460.1 Adult Male Accessory Gland    503.7 Adult Carcass    643.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1625.225 Larval Midgut    636 Larval Hindgut    470.3 Larval Malpighian Tubules    397.9 Larval Fat Body    477.2 Larval Salivary Gland    1122.9 Larval Trachea    767.6 Larval Carcass    445.5 Adult Head    767.4 Adult Eye    1533.75 Adult Brain    636 Adult Thoracic-Abdominal Ganglion    578.5 Adult Crop    504.3 Adult Midgut    1499.7 Adult Hindgut    786.9 Adult Malpighian Tubules    135.7 Adult Fat Body    607.8 Adult Salivary Gland    1907.7 Adult Heart    711.725 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    212.3 Adult Ovary    579.8 Adult Testis    460.1 Adult Male Accessory Gland    503.7 Adult Carcass    643.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    767.4   NA  Eye    1533.75   NA  Brain    636   1625.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    578.5   NA  Crop    504.3   636  Midgut    1499.7   470.3  Hindgut    786.9   397.9  Malpighian Tubules    135.7   477.2  Fat Body    607.8   1122.9  Salivary Gland    1907.7   NA  Heart    711.725   767.6  Trachea    NA   NA  VirginFemale Spermatheca    246.8   NA  InseminatedFemale Spermatheca    212.3   NA  Ovary    579.8   NA  Testis    460.1   NA  Male Accessory Gland    503.7   445.5  Carcass    643.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014857 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5825-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 His3.3AGD4748 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of His3.3A Class Mutagen Stocks Known lesion His3.3A5-HA-1043 1 -- His3.3A5-HA-3051 1 -- His3.3AKG02455 P-element activity 1 -- His3.3A2X1 Delta2-3 0 Yes His3.3AKO P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of His3.3A Class Mutagen Stocks Known lesion His3.3AGD4748 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes His3.3AKK111754 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes His3.3AA87S.hs.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes His3.3Acopia.LTR.T:Disc\RFP-mRFP in vitro construct - regulatory fusion 0 Yes His3.3Acore.hs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes His3.3Acore.MtnA.BLRP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes His3.3AG90M.hs.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes His3.3AH3.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes His3.3Ahs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes His3.3AHsp83.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes His3.3AI89V.hs.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes His3.3AK4R.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes His3.3AK9R.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes His3.3AMtnA.BLRP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes His3.3AS31A.hs.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes His3.3AS31A.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes His3.3AT:Zzzz\FLAG.cSa in vitro construct - coding region fusion 0 Yes His3.3AT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes His3.3AΔ310.hs.T:Avic\GFP in vitro construct - deletion 0 Yes His3.3AΔ319.hs.T:Avic\GFP in vitro construct - deletion 0 Yes His3.3AΔ335.hs.T:Avic\GFP in vitro construct - deletion 0 Yes His3.3AΔ342.hs.T:Avic\GFP in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7022 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{Act5C-EGFP,Hsp83-His3.3A.FLAG} NA P{hs-His3.3A.core.GFP} NA P{hs-His3.3A.GFP} NA UAS construct P{GD4748} NA P{KK111754} NA characterization construct P{His3.3A.FLAG.H3} NA P{His3.3A.FLAG.K4R} NA P{His3.3A.FLAG.K9R} NA P{His3.3A.FLAG.S31A} NA P{His3.3A.FLAG} NA P{His3.3A-Flag} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?'RS5}His3.3AKO NA P{RS5}His3.3A5-HA-1043 NA P{RS5}His3.3A5-HA-3051 NA P{SUPor-P}His3.3AKG02455 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from mutant phenotype (Kiger et al., 2003) male meiosis inferred from genetic interaction with His3.3B (Sakai et al., 2009) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component
CV term Evidence References
polytene chromosome inferred from direct assay (Sakai et al., 2009)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from sequence or structural similarity with NCBI_gi:484530 (FlyBase, 1992-)
Biological Process
CV term Evidence References
chromatin assembly or disassembly inferred from sequence or structural similarity with NCBI_gi:484530 (FlyBase, 1992-) nucleosome assembly inferred from electronic annotation with InterPro:IPR000164 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleosome inferred from sequence or structural similarity with NCBI_gi:484530 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions His3.3A allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59912 DroID - A comprehensive database of gene and protein interactions. • FBgn0014857 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33736
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15720 Dere\GG25048 Dgri\GH11489 Dmoj\GI16984 Dper\GL26550 Dsec\GM18523 Dsim\GD23319 Dvir\GJ17231 Dwil\GK23881
Curated drosophilid orthologs	Dhyd\His3.3A   Dpse\GA19158   Dyak\His3.3A
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006158-PA Aedes aegypti (mosquito) AGAP001813-PA Anopheles gambiae (mosquito) XP_001120696.1 Apis mellifera (honey bee) XP_624499.1 Apis mellifera (honey bee) XP_001949472.1 Acyrthosiphon pisum (pea aphid) XP_001949594.1 Acyrthosiphon pisum (pea aphid) 20154 Batrachochytrium dendrobatidis (chytrid fungus) 117519 Branchiostoma floridae (lancelet) 120758 Branchiostoma floridae (lancelet) 120760 Branchiostoma floridae (lancelet) XP_001897416.1 Brugia malayi (roundworm nematode) BGIBMGA005550-PA Bombyx mori (silk worm) ENSBTAP00000034086 Bos taurus (bovine) ENSBTAP00000034581 Bos taurus (bovine) CAL0001203 Candida albicans (a form of yeast) CAL0001692 Candida albicans (a form of yeast) CBP04026 Caenorhabditis briggsae (nematode) CE01943 Caenorhabditis elegans (worm) ENSCAFP00000023742 Canis familiaris (dog) ENSCAFP00000034160 Canis familiaris (dog) CAGL0C04114g Candida glabrata (haploid yeast) CAGL0H09856g Candida glabrata (haploid yeast) CAGL0M06655g Candida glabrata (haploid yeast) JA15814 Caenorhabditis japonica (nematode) cn02517 Cryptococcus neoformans (yeast-like fungus) cn10093 Cryptococcus neoformans (yeast-like fungus) CPIJ017187 Culex pipens (mosquito) ENSCPOP00000004239 Cavia porcellus (guinea pig) RP05930 Caenorhabditis remanei (nematode) ENSCSAVP00000007468 Ciona savignyi (sedentary tunicate) ENSCSAVP00000015809 Ciona savignyi (sedentary tunicate) 152257 Capitella spl (polychaete worm) DDB0191157 Dictyostelium discoideum (amoeba) DEHA2A10538g Debaryomyces Hansenii (yeast) DEHA2D12694g Debaryomyces Hansenii (yeast) 231307 Daphnia pulex (daphnia) ENSDARP00000006849 Danio rerio (zebra fish) ENSDARP00000047268 Danio rerio (zebra fish) ENSDARP00000066544 Danio rerio (zebra fish) ENSDARP00000087462 Danio rerio (zebra fish) ENSDARP00000089753 Danio rerio (zebra fish) ENSECAP00000005033 Equus caballus (horse) ENSECAP00000014555 Equus caballus (horse) XP_651949 Entamoeba histolytica (anaerobic protozoan) XP_656941 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000006729 Gymnopilus aculeatus (mushroom) ENSGACP00000007644 Gymnopilus aculeatus (mushroom) ENSGACP00000011861 Gymnopilus aculeatus (mushroom) ENSGALP00000003584 Gallus gallus (chicken) GL50803_135231 Giardia lamblia (flagellated protozoan) GL50803_14212 Giardia lamblia (flagellated protozoan) 185455 Hypsipyla robusta (cedar shoot borer) ENSP00000254810 Homo sapiens (human) ENSP00000355781 Homo sapiens (human) ENSP00000364327 Homo sapiens (human) ISCW002300-PA Ixodes scapularis (deer tick) KLLA0E08625g Kluyveromyces lactis (yeast) KLLA0E17623g Kluyveromyces lactis (yeast) 150994 Lottia gigantea (owl limpet) 20088 Monocosta brevicollis (choanoflagellate) ENSMODP00000007401 Monodelphis domestica (gray opossum) ENSMMUP00000028664 Macaca mulatta (rhesus monkey) ENSMMUP00000037589 Macaca mulatta (rhesus monkey) ENSMMUP00000037760 Macaca mulatta (rhesus monkey) ENSMMUP00000038421 Macaca mulatta (rhesus monkey) ENSMUSP00000079816 Mus musculus (house mouse) ENSMUSP00000102062 Mus musculus (house mouse) 194445 Nematostella vectensis (starlet anemone) XP_001608164.1 Nasonia vitripennis (wasp) XP_001608174.1 Nasonia vitripennis (wasp) ENSOANP00000002357 Ornithorynchus anatinus (platypus) ENSORLP00000009629 Oryzias latipes (japanese killifish) ENSORLP00000010883 Oryzias latipes (japanese killifish) PHUM001647-PA Pediculus humanus (human body louse) PP01725 Pristionchus pacificus (nematode) ENSPPYP00000000166 Pongo pygmaeus (orangutan) ENSPTRP00000016407 Pan troglodytes (chimpanzee) ENSPTRP00000021631 Pan troglodytes (chimpanzee) ENSRNOP00000004329 Rattus norvegicus (norway rat) YBR010W Saccharomyces cerevisiae (budding yeast) YNL031C Saccharomyces cerevisiae (budding yeast) Smp_082240 Schistosoma mansoni (trematode parasite) SPAC1834.04 Schizosaccharomyces pombe (fission yeast) SPBC1105.11c Schizosaccharomyces pombe (fission yeast) SPBC8D2.04 Schizosaccharomyces pombe (fission yeast) XP_791252.1 Strongylocentrotus purpuratus (purple sea urchin) XP_791401.1 Strongylocentrotus purpuratus (purple sea urchin) XP_798909.1 Strongylocentrotus purpuratus (purple sea urchin) 36142 Trichoplax adhaerens (metazoa) XP_975889.1 Tribolium castaneum (red flour beetle) Tc00.1047053505931.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053505931.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507817.18 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507817.9 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.59 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.68 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.77 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.86 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014465 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000014583 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000017348 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011674 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000011743 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000015496 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000017612 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000039814 Takifugu rubripes (pufferfish Takifugu) 80710.m00049 Trichomonas vaginalis (parasitic flagellated protozoan) 83111.m00133 Trichomonas vaginalis (parasitic flagellated protozoan) 83711.m00115 Trichomonas vaginalis (parasitic flagellated protozoan) 84511.m00341 Trichomonas vaginalis (parasitic flagellated protozoan) 84891.m00157 Trichomonas vaginalis (parasitic flagellated protozoan) 87349.m00145 Trichomonas vaginalis (parasitic flagellated protozoan) 87835.m00255 Trichomonas vaginalis (parasitic flagellated protozoan) 88273.m00353 Trichomonas vaginalis (parasitic flagellated protozoan) 89234.m00092 Trichomonas vaginalis (parasitic flagellated protozoan) 89272.m00071 Trichomonas vaginalis (parasitic flagellated protozoan) 89272.m00072 Trichomonas vaginalis (parasitic flagellated protozoan) 90936.m00074 Trichomonas vaginalis (parasitic flagellated protozoan) 92069.m00235 Trichomonas vaginalis (parasitic flagellated protozoan) 94102.m00136 Trichomonas vaginalis (parasitic flagellated protozoan) 94535.m00083 Trichomonas vaginalis (parasitic flagellated protozoan) 95674.m00205 Trichomonas vaginalis (parasitic flagellated protozoan) 95912.m00291 Trichomonas vaginalis (parasitic flagellated protozoan) 96555.m00135 Trichomonas vaginalis (parasitic flagellated protozoan) 97417.m00086 Trichomonas vaginalis (parasitic flagellated protozoan) 97466.m00049 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000027509 Xenopus tropicalis (frog) ENSXETP00000028563 Xenopus tropicalis (frog) ENSXETP00000058030 Xenopus tropicalis (frog) YALI0F25905g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18138 PB18139 PB16064 PB15655 PB15222 NV50172 NV19246 NV19123 NV17231 NV17234 NV14202 NV14200 NV14153 NV14154 NV14026 NV12299 NV12256 NV12251 NV12246 NV12136 NV10502 ISCW002300 FBgn0234880 FBgn0068147 FBgn0227121 FBgn0226990 FBgn0225843 FBgn0223124 FBgn0221235 FBgn0221155 FBgn0220891 FBgn0214412 FBgn0212395 FBgn0210808 FBgn0210804 FBgn0210800 FBgn0210798 FBgn0210795 FBgn0210791 FBgn0210789 FBgn0209692 FBgn0209659 FBgn0209644 FBgn0206953 FBgn0205743 FBgn0205564 FBgn0205560 FBgn0204407 FBgn0204252 FBgn0203530 FBgn0203528 FBgn0203298 FBgn0202641 FBgn0202502 FBgn0202362 FBgn0194705 FBgn0193401 FBgn0190513 FBgn0189544 FBgn0187414 FBgn0187101 FBgn0186784 FBgn0186525 FBgn0186138 FBgn0185374 FBgn0184758 FBgn0184426 FBgn0184322 FBgn0183726 FBgn0183605 FBgn0181580 FBgn0181514 FBgn0179986 FBgn0179828 FBgn0179058 FBgn0178292 FBgn0176974 FBgn0176827 FBgn0175833 FBgn0174658 FBgn0174652 FBgn0174640 FBgn0174638 FBgn0174629 FBgn0174626 FBgn0174622 FBgn0174619 FBgn0174611 FBgn0174609 FBgn0174570 FBgn0174555 FBgn0174548 FBgn0174251 FBgn0174243 FBgn0174225 FBgn0174214 FBgn0174211 FBgn0173737 FBgn0173710 FBgn0173640 FBgn0173430 FBgn0172352 FBgn0172308 FBgn0171791 FBgn0171312 FBgn0171195 FBgn0171196 FBgn0171173 FBgn0171148 FBgn0171089 FBgn0171024 FBgn0170371 FBgn0170053 FBgn0168607 FBgn0168560 FBgn0168557 FBgn0168513 FBgn0168474 FBgn0168127 FBgn0168124 FBgn0168110 FBgn0168070 FBgn0168055 FBgn0167322 FBgn0167015 FBgn0166654 FBgn0166651 FBgn0166129 FBgn0166126 FBgn0166111 FBgn0166093 FBgn0165987 FBgn0165751 JGI_V11_43804 JGI_V11_235586 JGI_V11_235594 JGI_V11_44116 JGI_V11_235620 JGI_V11_43602 JGI_V11_44125 JGI_V11_43862 JGI_V11_44149 JGI_V11_43482 JGI_V11_44114 JGI_V11_44153 JGI_V11_43874 JGI_V11_43597 JGI_V11_43405 JGI_V11_235802 JGI_V11_43402 JGI_V11_43441 JGI_V11_43863 JGI_V11_44115 JGI_V11_43467 JGI_V11_43440 JGI_V11_304645 JGI_V11_255862 JGI_V11_231307 JGI_V11_67712 FBgn0244101 FBgn0079155 FBgn0164412 FBgn0164132 FBgn0161551 FBgn0161548 FBgn0161545 FBgn0161541 FBgn0159965 FBgn0157299 FBgn0155404 FBgn0147577 FBgn0146172 FBgn0146168 FBgn0146166 FBgn0146164 FBgn0144605 FBgn0139999 FBgn0139995 FBgn0139997 FBgn0139730 FBgn0139639 FBgn0137630 FBgn0135470 FBgn0134019 FBgn0132806 FBgn0053866 FBgn0053863 FBgn0053860 FBgn0053857 FBgn0053854 FBgn0053851 FBgn0053848 FBgn0053845 FBgn0053842 FBgn0053839 FBgn0053836 FBgn0053833 FBgn0053830 FBgn0053827 FBgn0053824 FBgn0053821 FBgn0053818 FBgn0053815 FBgn0053812 FBgn0053809 FBgn0053806 FBgn0053803 FBgn0051613 FBgn0004828 FBgn0132640 FBgn0132638 FBgn0132634 FBgn0132632 FBgn0132631 FBgn0132628 FBgn0132623 FBgn0132617 FBgn0132620 FBgn0132615 FBgn0132613 FBgn0132610 FBgn0132607 FBgn0132603 FBgn0132455 FBgn0132404 FBgn0132178 FBgn0131333 FBgn0131222 FBgn0131219 FBgn0131206 FBgn0131029 FBgn0130970 FBgn0130961 FBgn0130926 FBgn0130801 FBgn0130796 FBgn0130791 FBgn0130789 FBgn0130714 FBgn0121412 FBgn0118969 FBgn0117652 FBgn0117630 FBgn0117177 FBgn0113513 FBgn0113512 FBgn0113509 FBgn0113505 FBgn0113502 FBgn0113499 FBgn0113495 FBgn0113492 FBgn0113489 FBgn0113486 FBgn0112051 FBgn0112031 FBgn0112017 FBgn0112007 FBgn0111992 FBgn0111206 FBgn0110459 FBgn0108601 FBgn0108589 FBgn0099849 FBgn0099291 FBgn0099263 FBgn0099231 FBgn0099199 FBgn0098669 FBgn0098608 FBgn0098522 FBgn0097387 FBgn0097366 FBgn0097172 FBgn0096182 FBgn0095994 FBgn0092945 FBgn0092910 FBgn0092744 FBgn0090932 CPIJ017187 CPIJ015006 CPIJ014769 CPIJ012453 CPIJ012449 CPIJ012445 CPIJ012441 CPIJ012437 CPIJ012433 CPIJ012429 CPIJ012424 CPIJ012420 CPIJ012418 CPIJ012411 CPIJ012407 CPIJ012402 CPIJ012398 CPIJ012394 CPIJ012389 CPIJ012384 CPIJ012379 CPIJ006050 BGIBMGA009648 BGIBMGA005550 ACYPI008300 ACYPI007671 ACYPI007201 ACYPI000605 GB14620 GB12948 GB11228 GB11223 AGAP012709 AGAP012573 AGAP012572 AGAP012559 AGAP005024 AGAP005025 AGAP003910 AGAP001813 AAEL012072 AAEL006158 AAEL003856 AAEL003852 AAEL003850 AAEL003836 AAEL003828 AAEL003827 AAEL003685 AAEL003659 AAEL000506 AAEL000492 AAEL000482 PB21863 GLEAN_06933 GLEAN_05398 GLEAN_05139 GLEAN_01497 GLEAN_16050
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	13315 y1 w67c23; P{SUPor-P}His3.3AKG02455
Kyoto	125027 w1118; P{RS5}His3.3A5-HA-1043 125787 w1118; P{RS5}His3.3A5-HA-3051
VDRC	v106516 P{KK111754}VIE-260B v12769 w1118 P{GD4748}v12769
Genomic Clones ( 1 )
	BACR13M11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 208 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD17717 RE14004 RE21618
Other clones	yak-em_His3
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01868 AT19093 GH08293 GH16032 GM04142 GM05689 GM25926 GM29381 LD11584 LD25548 LD30804 LD45863 RE09794 RE13754 RE14214 RE29781 RE33245 RE33262 RE39478 RE40131 RE41770 RE44664 RE44692 RE45342 RE50589 RE52816 RE53151 RE54517 RE54606 RE56614 RE61526 RE64074 RE65981 RE67395 RE68484 RE69182 RE70901 RE74771 RH04642 RH04786 RH04792 RH06334 RH06831 RH07215 RH07463 RH08052 RH08094 RH09712 RH13983 RH17279 RH21863 RH21885 RH23392 RH25646 RH26232 RH26689 RH26992 RH27248 RH27541 RH28032 RH28071 RH28078 RH28150 RH28267 RH28315 RH29252 RH29870 RH32123 RH33057 RH33676 RH34077 RH34721 RH34945 RH35016 RH36172 RH36756 RH36763 RH37647 RH42354 RH43189 RH44677 RH45764 RH46316 RH48795 RH48936 RH52318 RH52653 RH53951 RH54602 RH54715 RH55172 RH56233 RH56891 RH58811 RH59993 RH61542 RH63512 RH72126 SD18607 SD23667
Other clones	bs13a05 EC32385 EC35135 EK096159 EN12263 FGM004D03 FGM102C10 FGM208C11 FGM230E01 FGM324A05 RP004019999 RP004021435 RP004034948 RP004054795 RP004057370 RP004059612 RP004059773 RP004067308 RP004075664 RP004078335 RP004085119 RP004087677 RP004106616 RP004118374 RP004123365 RP004125198 RP004126305 RP004128174 RP004130165 RP004133245 RP004140995 RP004145967 RP004146165 RP004156796 RP004169644 RP004173340 RP004174218 RP004179214 RP004190016 RP004191248 RP004194052 RP004196558 RP004197074 RP004200096 RP004202269 RP004204207 RP004204328 RP004206733 RP004207347 RP004209018 RP004210731 RP004220362 RP004223428 RP004227608 RP004234417 RP004239766 RP004245086 RP004247325 RP004253229 RP004254095 RP004262680 RP004287813 RP004298060 RP004298694 RP004306298 RP004313028 RP004316412 RP004319310 RP004322337 RP004342751 RP004353460 RP004355549 RP004365767 RP004368226 RP004368801 RP004371069 RP004378449 RP004406045 RP004411373 RP004412184 RP004413492 RP004418338 RP004432628 RP004437539 RP004440598 RP004443399 RP004444110 RP004447856 RP004469558 RP004487588 RP004491991 RP004493673 RP004494557 RP004495562 RP004500348 RP004514646 RP004515920 RP004528027 RP004544115 RP004545260 RP004546726 RP004551055 RP004557682 RP004558899
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014857 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33736
Antibody Information
	polyclonal (Akhmanova et al., 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Nucleosomes containing His3.3A protein but not His3 protein are specifically assembled in paternal chromatin before the first round of DNA replication in the fertilised egg. (Loppin et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cells become round and detached. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Replication independent deposition of His3.3A occurs at particular loci, including active rDNA arrays. (Ahmad and Henikoff, 2002) His3.3A has been cloned and sequenced. (Akhmanova et al., 1995) The histone H3.3 replacement variant is encoded by two genes, His3.3A and His3.3B, in D.melanogaster. These genes encode exactly the same protein but are widely divergent in their untranslated regions. (Akhmanova et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078755 NM_164624 RefSeq (Proteins) • NP_523479 NP_723056 DDBJ / EMBL / GenBank • AAF52213 AAF52213.1 AAL48679 AAM50283 AAN10526 AAN10526.1 AAQ96278 AI513654 AI945449 AY071057 AY119629 AY383571 BH615067 BI172070 BI215264 CAA57712 X82257 Entrez Gene - A searchable database of RefSeq genes. • 33736 UniProtKB/Swiss-Prot • P84249 UniProtKB/TrEMBL • E2QCP0 Q6TXQ1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histone H3 (IPR000164) Histone core (IPR007125) Histone-fold (IPR009072)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59912 DroID - A comprehensive database of gene and protein interactions. • FBgn0014857 DRSC - Results from RNAi screens. • FBgn0014857 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014857 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5825-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014857 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33736 InParanoid A subset of ortholog calls from InParanoid. • AAEL006158-PA Aedes aegypti (mosquito) AGAP001813-PA Anopheles gambiae (mosquito) XP_001120696.1 Apis mellifera (honey bee) XP_624499.1 Apis mellifera (honey bee) XP_001949472.1 Acyrthosiphon pisum (pea aphid) XP_001949594.1 Acyrthosiphon pisum (pea aphid) 20154 Batrachochytrium dendrobatidis (chytrid fungus) 117519 Branchiostoma floridae (lancelet) 120758 Branchiostoma floridae (lancelet) 120760 Branchiostoma floridae (lancelet) XP_001897416.1 Brugia malayi (roundworm nematode) BGIBMGA005550-PA Bombyx mori (silk worm) ENSBTAP00000034086 Bos taurus (bovine) ENSBTAP00000034581 Bos taurus (bovine) CAL0001203 Candida albicans (a form of yeast) CAL0001692 Candida albicans (a form of yeast) CBP04026 Caenorhabditis briggsae (nematode) CE01943 Caenorhabditis elegans (worm) ENSCAFP00000023742 Canis familiaris (dog) ENSCAFP00000034160 Canis familiaris (dog) CAGL0C04114g Candida glabrata (haploid yeast) CAGL0H09856g Candida glabrata (haploid yeast) CAGL0M06655g Candida glabrata (haploid yeast) JA15814 Caenorhabditis japonica (nematode) cn02517 Cryptococcus neoformans (yeast-like fungus) cn10093 Cryptococcus neoformans (yeast-like fungus) CPIJ017187 Culex pipens (mosquito) ENSCPOP00000004239 Cavia porcellus (guinea pig) RP05930 Caenorhabditis remanei (nematode) ENSCSAVP00000007468 Ciona savignyi (sedentary tunicate) ENSCSAVP00000015809 Ciona savignyi (sedentary tunicate) 152257 Capitella spl (polychaete worm) DDB0191157 Dictyostelium discoideum (amoeba) DEHA2A10538g Debaryomyces Hansenii (yeast) DEHA2D12694g Debaryomyces Hansenii (yeast) 231307 Daphnia pulex (daphnia) ENSDARP00000006849 Danio rerio (zebra fish) ENSDARP00000047268 Danio rerio (zebra fish) ENSDARP00000066544 Danio rerio (zebra fish) ENSDARP00000087462 Danio rerio (zebra fish) ENSDARP00000089753 Danio rerio (zebra fish) ENSECAP00000005033 Equus caballus (horse) ENSECAP00000014555 Equus caballus (horse) XP_651949 Entamoeba histolytica (anaerobic protozoan) XP_656941 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000006729 Gymnopilus aculeatus (mushroom) ENSGACP00000007644 Gymnopilus aculeatus (mushroom) ENSGACP00000011861 Gymnopilus aculeatus (mushroom) ENSGALP00000003584 Gallus gallus (chicken) GL50803_135231 Giardia lamblia (flagellated protozoan) GL50803_14212 Giardia lamblia (flagellated protozoan) 185455 Hypsipyla robusta (cedar shoot borer) ENSP00000254810 Homo sapiens (human) ENSP00000355781 Homo sapiens (human) ENSP00000364327 Homo sapiens (human) ISCW002300-PA Ixodes scapularis (deer tick) KLLA0E08625g Kluyveromyces lactis (yeast) KLLA0E17623g Kluyveromyces lactis (yeast) 150994 Lottia gigantea (owl limpet) 20088 Monocosta brevicollis (choanoflagellate) ENSMODP00000007401 Monodelphis domestica (gray opossum) ENSMMUP00000028664 Macaca mulatta (rhesus monkey) ENSMMUP00000037589 Macaca mulatta (rhesus monkey) ENSMMUP00000037760 Macaca mulatta (rhesus monkey) ENSMMUP00000038421 Macaca mulatta (rhesus monkey) ENSMUSP00000079816 Mus musculus (house mouse) ENSMUSP00000102062 Mus musculus (house mouse) 194445 Nematostella vectensis (starlet anemone) XP_001608164.1 Nasonia vitripennis (wasp) XP_001608174.1 Nasonia vitripennis (wasp) ENSOANP00000002357 Ornithorynchus anatinus (platypus) ENSORLP00000009629 Oryzias latipes (japanese killifish) ENSORLP00000010883 Oryzias latipes (japanese killifish) PHUM001647-PA Pediculus humanus (human body louse) PP01725 Pristionchus pacificus (nematode) ENSPPYP00000000166 Pongo pygmaeus (orangutan) ENSPTRP00000016407 Pan troglodytes (chimpanzee) ENSPTRP00000021631 Pan troglodytes (chimpanzee) ENSRNOP00000004329 Rattus norvegicus (norway rat) YBR010W Saccharomyces cerevisiae (budding yeast) YNL031C Saccharomyces cerevisiae (budding yeast) Smp_082240 Schistosoma mansoni (trematode parasite) SPAC1834.04 Schizosaccharomyces pombe (fission yeast) SPBC1105.11c Schizosaccharomyces pombe (fission yeast) SPBC8D2.04 Schizosaccharomyces pombe (fission yeast) XP_791252.1 Strongylocentrotus purpuratus (purple sea urchin) XP_791401.1 Strongylocentrotus purpuratus (purple sea urchin) XP_798909.1 Strongylocentrotus purpuratus (purple sea urchin) 36142 Trichoplax adhaerens (metazoa) XP_975889.1 Tribolium castaneum (red flour beetle) Tc00.1047053505931.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053505931.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507817.18 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507817.9 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.59 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.68 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.77 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509471.86 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014465 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000014583 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000017348 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011674 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000011743 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000015496 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000017612 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000039814 Takifugu rubripes (pufferfish Takifugu) 80710.m00049 Trichomonas vaginalis (parasitic flagellated protozoan) 83111.m00133 Trichomonas vaginalis (parasitic flagellated protozoan) 83711.m00115 Trichomonas vaginalis (parasitic flagellated protozoan) 84511.m00341 Trichomonas vaginalis (parasitic flagellated protozoan) 84891.m00157 Trichomonas vaginalis (parasitic flagellated protozoan) 87349.m00145 Trichomonas vaginalis (parasitic flagellated protozoan) 87835.m00255 Trichomonas vaginalis (parasitic flagellated protozoan) 88273.m00353 Trichomonas vaginalis (parasitic flagellated protozoan) 89234.m00092 Trichomonas vaginalis (parasitic flagellated protozoan) 89272.m00071 Trichomonas vaginalis (parasitic flagellated protozoan) 89272.m00072 Trichomonas vaginalis (parasitic flagellated protozoan) 90936.m00074 Trichomonas vaginalis (parasitic flagellated protozoan) 92069.m00235 Trichomonas vaginalis (parasitic flagellated protozoan) 94102.m00136 Trichomonas vaginalis (parasitic flagellated protozoan) 94535.m00083 Trichomonas vaginalis (parasitic flagellated protozoan) 95674.m00205 Trichomonas vaginalis (parasitic flagellated protozoan) 95912.m00291 Trichomonas vaginalis (parasitic flagellated protozoan) 96555.m00135 Trichomonas vaginalis (parasitic flagellated protozoan) 97417.m00086 Trichomonas vaginalis (parasitic flagellated protozoan) 97466.m00049 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000027509 Xenopus tropicalis (frog) ENSXETP00000028563 Xenopus tropicalis (frog) ENSXETP00000058030 Xenopus tropicalis (frog) YALI0F25905g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/histone3-3-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33736 modMine - Data generated by the modENCODE project. • FBgn0014857 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18138 PB18139 PB16064 PB15655 PB15222 NV50172 NV19246 NV19123 NV17231 NV17234 NV14202 NV14200 NV14153 NV14154 NV14026 NV12299 NV12256 NV12251 NV12246 NV12136 NV10502 ISCW002300 FBgn0234880 FBgn0068147 FBgn0227121 FBgn0226990 FBgn0225843 FBgn0223124 FBgn0221235 FBgn0221155 FBgn0220891 FBgn0214412 FBgn0212395 FBgn0210808 FBgn0210804 FBgn0210800 FBgn0210798 FBgn0210795 FBgn0210791 FBgn0210789 FBgn0209692 FBgn0209659 FBgn0209644 FBgn0206953 FBgn0205743 FBgn0205564 FBgn0205560 FBgn0204407 FBgn0204252 FBgn0203530 FBgn0203528 FBgn0203298 FBgn0202641 FBgn0202502 FBgn0202362 FBgn0194705 FBgn0193401 FBgn0190513 FBgn0189544 FBgn0187414 FBgn0187101 FBgn0186784 FBgn0186525 FBgn0186138 FBgn0185374 FBgn0184758 FBgn0184426 FBgn0184322 FBgn0183726 FBgn0183605 FBgn0181580 FBgn0181514 FBgn0179986 FBgn0179828 FBgn0179058 FBgn0178292 FBgn0176974 FBgn0176827 FBgn0175833 FBgn0174658 FBgn0174652 FBgn0174640 FBgn0174638 FBgn0174629 FBgn0174626 FBgn0174622 FBgn0174619 FBgn0174611 FBgn0174609 FBgn0174570 FBgn0174555 FBgn0174548 FBgn0174251 FBgn0174243 FBgn0174225 FBgn0174214 FBgn0174211 FBgn0173737 FBgn0173710 FBgn0173640 FBgn0173430 FBgn0172352 FBgn0172308 FBgn0171791 FBgn0171312 FBgn0171195 FBgn0171196 FBgn0171173 FBgn0171148 FBgn0171089 FBgn0171024 FBgn0170371 FBgn0170053 FBgn0168607 FBgn0168560 FBgn0168557 FBgn0168513 FBgn0168474 FBgn0168127 FBgn0168124 FBgn0168110 FBgn0168070 FBgn0168055 FBgn0167322 FBgn0167015 FBgn0166654 FBgn0166651 FBgn0166129 FBgn0166126 FBgn0166111 FBgn0166093 FBgn0165987 FBgn0165751 JGI_V11_43804 JGI_V11_235586 JGI_V11_235594 JGI_V11_44116 JGI_V11_235620 JGI_V11_43602 JGI_V11_44125 JGI_V11_43862 JGI_V11_44149 JGI_V11_43482 JGI_V11_44114 JGI_V11_44153 JGI_V11_43874 JGI_V11_43597 JGI_V11_43405 JGI_V11_235802 JGI_V11_43402 JGI_V11_43441 JGI_V11_43863 JGI_V11_44115 JGI_V11_43467 JGI_V11_43440 JGI_V11_304645 JGI_V11_255862 JGI_V11_231307 JGI_V11_67712 FBgn0244101 FBgn0079155 FBgn0164412 FBgn0164132 FBgn0161551 FBgn0161548 FBgn0161545 FBgn0161541 FBgn0159965 FBgn0157299 FBgn0155404 FBgn0147577 FBgn0146172 FBgn0146168 FBgn0146166 FBgn0146164 FBgn0144605 FBgn0139999 FBgn0139995 FBgn0139997 FBgn0139730 FBgn0139639 FBgn0137630 FBgn0135470 FBgn0134019 FBgn0132806 FBgn0053866 FBgn0053863 FBgn0053860 FBgn0053857 FBgn0053854 FBgn0053851 FBgn0053848 FBgn0053845 FBgn0053842 FBgn0053839 FBgn0053836 FBgn0053833 FBgn0053830 FBgn0053827 FBgn0053824 FBgn0053821 FBgn0053818 FBgn0053815 FBgn0053812 FBgn0053809 FBgn0053806 FBgn0053803 FBgn0051613 FBgn0004828 FBgn0132640 FBgn0132638 FBgn0132634 FBgn0132632 FBgn0132631 FBgn0132628 FBgn0132623 FBgn0132617 FBgn0132620 FBgn0132615 FBgn0132613 FBgn0132610 FBgn0132607 FBgn0132603 FBgn0132455 FBgn0132404 FBgn0132178 FBgn0131333 FBgn0131222 FBgn0131219 FBgn0131206 FBgn0131029 FBgn0130970 FBgn0130961 FBgn0130926 FBgn0130801 FBgn0130796 FBgn0130791 FBgn0130789 FBgn0130714 FBgn0121412 FBgn0118969 FBgn0117652 FBgn0117630 FBgn0117177 FBgn0113513 FBgn0113512 FBgn0113509 FBgn0113505 FBgn0113502 FBgn0113499 FBgn0113495 FBgn0113492 FBgn0113489 FBgn0113486 FBgn0112051 FBgn0112031 FBgn0112017 FBgn0112007 FBgn0111992 FBgn0111206 FBgn0110459 FBgn0108601 FBgn0108589 FBgn0099849 FBgn0099291 FBgn0099263 FBgn0099231 FBgn0099199 FBgn0098669 FBgn0098608 FBgn0098522 FBgn0097387 FBgn0097366 FBgn0097172 FBgn0096182 FBgn0095994 FBgn0092945 FBgn0092910 FBgn0092744 FBgn0090932 CPIJ017187 CPIJ015006 CPIJ014769 CPIJ012453 CPIJ012449 CPIJ012445 CPIJ012441 CPIJ012437 CPIJ012433 CPIJ012429 CPIJ012424 CPIJ012420 CPIJ012418 CPIJ012411 CPIJ012407 CPIJ012402 CPIJ012398 CPIJ012394 CPIJ012389 CPIJ012384 CPIJ012379 CPIJ006050 BGIBMGA009648 BGIBMGA005550 ACYPI008300 ACYPI007671 ACYPI007201 ACYPI000605 GB14620 GB12948 GB11228 GB11223 AGAP012709 AGAP012573 AGAP012572 AGAP012559 AGAP005024 AGAP005025 AGAP003910 AGAP001813 AAEL012072 AAEL006158 AAEL003856 AAEL003852 AAEL003850 AAEL003836 AAEL003828 AAEL003827 AAEL003685 AAEL003659 AAEL000506 AAEL000492 AAEL000482 PB21863 GLEAN_06933 GLEAN_05398 GLEAN_05139 GLEAN_01497 GLEAN_16050
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG5825 (Wagner et al., 2007, Keleman et al., 2009.8.5) dH3.3A (Wagner et al., 2007) H3.3 (Henikoff et al., 2009, Bonnefoy et al., 2007, Orian, 2006, Polo, 2006, Loppin et al., 2005, Schwartz and Ahmad, 2005, Heinkoff et al., 2004, Henikoff, 2004, Schwartz and Ahmad, 2004, McKittrick et al., 2004, Hennig, 2003, Ahmad and Henikoff, 2002, Goll and Bestor, 2002, Akhmanova et al., 1997, Akhmanova et al., 1995, McKittrick et al., 2004, Spradling, 2006, Li et al., 2007, Zhou, 2005, Ellis, 2006, Moorman et al., 2006, Jin, 2005, Mito et al., 2005, Konev et al., 2007, Graves and Tamkun, 2006, Konev et al., 2007, Nakayama et al., 2007, Schneiderman and Ahmad, 2008, Mito et al., 2007, Braunschweig et al., 2009, Fahrner and Baylin, 2003, Ahmad and Henikoff, 2002, de Wit et al., 2007, Bell et al., 2007, Doheny et al., 2008, Rathke et al., 2007, Schneiderman et al., 2009, van Steensel et al., 2010, Macalpine et al., 2010, Sawatsubashi et al., 2010, Deal et al., 2010, Pinnola et al., 2007, modENCODE Consortium et al., 2010, Guertin and Lis, 2010) H3.3A (Wagner et al., 2007, Doheny et al., 2008, Shevelyov et al., 2009, Feng et al., 2005) His3.3 (Kamakaka, 2005, Lippman and Martienssen, 2004, Cavalli, 2006) His3.3A (Dorus et al., 2006, Hödl and Basler, 2009, Sakai et al., 2009, de Wit et al., 2008, Mourikis et al., 2010) His-3.3A (Shevelyov et al., 2009) PH3 (Whittaker et al., 2000, Su et al., 1999)
Name Synonym	H3L-like histone (Mancini, 2003.9.9) histone H3.3 (Mito et al., 2005, Wirbelauer et al., 2005, Ringrose and Paro, 2007, Rathke et al., 2007) histone H3.3A (Bindels, 1994.10.20) Histone H3.3A (Doheny et al., 2008) histone H3.3 variant (Bonnefoy et al., 2007) histone variant 3.3 (Ellis, 2006) histone variant H3.3 (Zhou, 2005)
Secondary FlyBase IDs
References ( 86 )
Generate a list of	All references relating to this gene ( 86 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 7 ) Review  ( 16 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Conference report  ( 2 ) Meeting report  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Deal et al., 2010, Science 328(5982): 1161--1164 Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. [FBrf0210910] Guertin and Lis, 2010, PLoS Genet. 6(9): Chromatin Landscape Dictates HSF Binding to Target DNA Elements. [FBrf0211835] Macalpine et al., 2010, Genome Res. 20(2): 201--211 Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. [FBrf0209851] modENCODE Consortium et al., 2010, Science 330(6012): 1787--1797 Identification of functional elements and regulatory circuits by Drosophila modENCODE. [FBrf0212741] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Sawatsubashi et al., 2010, Genes Dev. 24(2): 159--170 A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. [FBrf0209754] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...