DHR38, 38E.3, 38E.7, NR4A4
Gene model reviewed during 5.48
None of the polypeptides share 100% sequence identity.
Forms a heterodimer with USP.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr38 using the Feature Mapper tool.
Hr38 expression was assayed by qRT-PCR on dissected tissues from third instar larvae. Hr38 transcripts are highly enriched in carcasses, which include epidermis and body wall. Low levels are seen in dissected gut and brain complex.
The ~5kb Hr38 transcript is detected at all stages by RT-PCR but is very low in early embryos and is most abundant in pupae. It is detected in a third instar larval brain and imaginal disc sample but not in ovaries. The 5kb transcript is enriched in pupae and adults relative to the 4kb transcript.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hr38 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hr38 CG1864
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
The genomic organisation of the Hr38 locus has been determined and its expression pattern has been analysed.
The results of overexpression in Schneider cells and larvae suggest that Hr38 plays a role in the ecdysone response, and point to the conclusion that NGFI-B-type receptors may function as heterodimers with RXR-type receptors in regulating transcription.