FB2020_04, released Aug 18, 2020

Gene: Dmel\Hr38

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General Information
Symbol
Dmel\Hr38
Species
D. melanogaster
Name
Hormone receptor-like in 38
Annotation Symbol
CG1864
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014859
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Snapshot
Hormone receptor-like in 38 (Hr38) encodes a protein that can heterodimerize with the U adult cuticle and for the proper uptake and storage of glycogen in larvae. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

DHR38, 38E.3, 38E.7, NR4A4

Key Links
Genomic Location
Cytogenetic map
38D5-38E3
Sequence location
2L:20,683,462..20,714,588 [-]
Recombination map

2-54

RefSeq locus
NT_033779 REGION:20683462..20714588
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Fisk and Thummel, 1995)
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR001628
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
glucocorticoid receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
nuclear receptor activity
non-traceable author statement
(Maglich et al., 2001)
RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
steroid hormone receptor activity
inferred from electronic annotation with InterPro:IPR001723
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
zinc ion binding
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cuticle development
inferred from mutant phenotype
(Kozlova et al., 2009)
regulation of adult chitin-containing cuticle pigmentation
inferred from genetic interaction with FLYBASE:Ask1; FB:FBgn0014006
(Sekine et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cellular response to corticotropin-releasing hormone stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:7980
(FlyBase Curators, 2008--)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:7981
(FlyBase Curators, 2008--)
transcription regulator complex
inferred from biological aspect of ancestor with PANTHER:PTN000639600
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the nuclear hormone receptor family. NR4 subfamily. (P49869)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -
Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).
Protein Function (UniProtKB)
Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.
(UniProt, P49869)
Summary (Interactive Fly)

nuclear receptor superfamily - participates in a second ecdysteroid signaling pathway that responds to a distinct class of ecdysteroids in a manner that is independent of EcR

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Hr38 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hr38-RB
FBtr0081397
NM_057771
7704
1078
Hr38-RD
FBtr0301347
NM_001169553
7044
836
Additional Transcript Data and Comments
Reported size (kB)

5.0, 4.0 (northern blot); 2.0 (unknown)

(Kozlova et al., 1998)

1.9 (northern blot)

(Fisk and Thummel, 1995)

5.2 (longest cDNA)

(Sutherland et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hr38-PB
FBpp0080927
117.4
1078
7.40
NP_477119
AAF53914
Hr38-PD
FBpp0290561
92.5
836
7.19
NP_001163024
ACZ94310
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1073 (aa); 117 (kD predicted)

(Kozlova et al., 1998)

551 (aa)

(Sutherland et al., 1995)
Comments
External Data
Subunit Structure (UniProtKB)

Forms a heterodimer with USP.

(UniProt, P49869)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr38 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Kozlova et al., 1998)
embryonic stage -- pupal stage
(Kozlova et al., 1998)
larval stage & prepupal stage
(Fisk and Thummel, 1995)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
epidermis
(Ruaud et al., 2011)
embryonic/larval somatic muscle
(Ruaud et al., 2011)
embryonic/larval gut
(Ruaud et al., 2011)
embryonic/larval brain
(Ruaud et al., 2011)
Additional Descriptive Data

Hr38 expression was assayed by qRT-PCR on dissected tissues from third instar larvae. Hr38 transcripts are highly enriched in carcasses, which include epidermis and body wall. Low levels are seen in dissected gut and brain complex.

(Ruaud et al., 2011)

The ~5kb Hr38 transcript is detected at all stages by RT-PCR but is very low in early embryos and is most abundant in pupae. It is detected in a third instar larval brain and imaginal disc sample but not in ovaries. The 5kb transcript is enriched in pupae and adults relative to the 4kb transcript.

(Kozlova et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hr38 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hr38
Transgenic constructs containing regulatory region of Hr38
Deletions and Duplications ( 20 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
lethal (with Df(2L)ED1317)
lethal | heat sensitive, with Scer\GAL4pnr-MD237
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal - all die before end of P-stage
lethal - all die before end of P-stage (with Df(2L)Fs(2)Ket-RX32)
lethal - all die before end of P-stage (with Hr3856)
lethal - all die before end of P-stage (with Hr38Y214)
lethal - all die before end of pupal stage (with Df(2L)Fs(2)Ket-RX32)
lethal - all die before end of pupal stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
flightless, with Scer\GAL4Mef2.PR
pain response defective | third instar larval stage, with Scer\GAL4ppk.1.9
sensory perception defective | third instar larval stage, with Scer\GAL4ppk.1.9
some die during immature adult stage | recessive
some die during pharate adult stage
some die during pharate adult stage (with Df(2L)Fs(2)Ket-RX32)
some die during pharate adult stage (with Hr3856)
some die during pharate adult stage (with Hr38Y214)
some die during pupal stage (with Df(2L)Fs(2)Ket-RX32)
some die during pupal stage | recessive
visible
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
visible | recessive
Phenotype manifest in
Allele
adult cuticle
adult epidermis
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Pxn.PS
indirect flight muscle, with Scer\GAL4Mef2.PR
joint
leg
myofibril, with Scer\GAL4Mef2.PR
pupal cuticle
pupal epidermis
sarcomere, with Scer\GAL4Mef2.PR
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NR4A2
13 of 15
Yes
Yes
Hsap\NR4A3
11 of 15
No
Yes
Hsap\NR4A1
10 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nr4a2
12 of 15
Yes
Yes
Mmus\Nr4a3
11 of 15
No
Yes
Mmus\Nr4a1
10 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Nr4a2
11 of 13
Yes
Yes
Rnor\Nr4a3
10 of 13
No
Yes
Rnor\Nr4a1
9 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\nr4a1
10 of 12
Yes
Yes
Xtro\nr4a2
9 of 12
No
Yes
Xtro\nr4a3
2 of 12
No
Yes
Danio rerio (Zebrafish) (5)
Drer\nr4a2a
11 of 15
Yes
Yes
Drer\nr4a2b
10 of 15
No
Yes
Drer\nr4a3
10 of 15
No
Yes
Drer\nr4a1
7 of 15
No
Yes
Drer\ar
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\nhr-6
12 of 15
Yes
Yes
Cele\dpr-1
1 of 15
No
Yes
Cele\nhr-234
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905GS )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000823
Drosophila simulans
Dsim\GD21688
Drosophila sechellia
Dsec\GM23314
Drosophila erecta
Dere\GG21557
Drosophila yakuba
Dyak\GE13549
Drosophila ananassae
Dana\GF14553
Drosophila pseudoobscura pseudoobscura
Dpse\GA15026
Drosophila persimilis
Dper\GL19597
Drosophila willistoni
Dwil\GK14909
Drosophila virilis
Dvir\GJ17428
Drosophila mojavensis
Dmoj\GI19631
Drosophila grimshawi
Dgri\GH10850
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509OJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014798
Glossina morsitans
Tsetse fly
Gmor\GMOY010425
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08886
Mayetiola destructor
Hessian fly
Mdes\Mdes010696
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013270
Anopheles darlingi
American malaria mosquito
Adar\ADAC003489
Anopheles gambiae
Malaria mosquito
Agam\GPROR9
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004609
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0ARP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002964
Danaus plexippus
Monarch butterfly
Dple\DPOGS211084-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012492
Apis florea
Little honeybee
Aflo\2147668035
Apis florea
Little honeybee
Aflo\2147491041
Apis mellifera
Western honey bee
Amel\GB49295
Apis mellifera
Western honey bee
Amel\GB40074
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20887
Bombus terrestris
Buff-tailed bumblebee
Bter\15205144
Linepithema humile
Argentine ant
Lhum\LH22053
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001785
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08217
Tribolium castaneum
Red flour beetle
Tcas\TC031157
Pediculus humanus
Human body louse
Phum\PHUM411130
Rhodnius prolixus
Kissing bug
Rpro\RPRC001680
Cimex lectularius
Bed bug
Clec\CLEC005658
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003909
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16131
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0AOU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012229
Ixodes scapularis
Black-legged tick
Isca\ISCW020982
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63859.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63858.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04710
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_220366
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GUM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nurr1
Ciona intestinalis
Vase tunicate
Cint\nr41/42/43
Gallus gallus
Domestic chicken
Ggal\NR4A3
Gallus gallus
Domestic chicken
Ggal\NR4A2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NR4A2; nuclear receptor subfamily 4 group A member 2
    13 of 15
    601828
        NR4A3; nuclear receptor subfamily 4 group A member 3
        11 of 15
        600542
        NR4A1; nuclear receptor subfamily 4 group A member 1
        10 of 15
        139139
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Ask1
            suppressible
            Hr38
            (Sekine et al., 2011)
            Dl
            enhanceable
            Hr38
            (Shalaby et al., 2009)
            External Data
            Subunit Structure (UniProtKB)
            Forms a heterodimer with USP.
            (UniProt, P49869 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map

            2-54

            Cytogenetic map
            38D5-38E3
            Sequence location
            2L:20,683,462..20,714,588 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            38D5-38E3
            Limits computationally determined from genome sequence between P{lacW}k02501&P{lacW}k14810 and P{PZ}Hr3802306&P{PZ}dia1
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            38E-38E
            (Kozlova, 1995.6.23)
            38E1-38E2
            (Kozlova, 1997.9.24, Fisk, 1995.9.20, BDGP Project Members, 1994-1999)
            38D1-38D2
            (determined by in situ hybridisation)
            (Semeshin et al., 1999)
            38E1-38E2
            (determined by in situ hybridisation)
            (Spradling et al., 1999, Fisk and Thummel, 1995)
            Experimentally Determined Recombination Data
            Location

            2-54

            (FlyBase, 2016)

            2-54.1

            (Comeron et al., 2012)

            2-

            (Kozlova, 1995.6.23)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (19)
            Genomic Clones (23)
            cDNA Clones (10)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Fujita et al., 2013, Davis et al., 2007)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Hr38 CG1864

              (Adams, 1999.11)
              Source for database merge of
              Additional comments
              Other Comments

              S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

              (Stroschein-Stevenson et al., 2006)

              Hr38 appears to mediate an atypical Ecdysteroid signalling pathway.

              (Baker et al., 2003)

              The genomic organisation of the Hr38 locus has been determined and its expression pattern has been analysed.

              (Komonyi et al., 1998)

              Hr38 plays an important role in late stages of epidermal morphogenesis.

              (Kozlova et al., 1998)

              The results of overexpression in Schneider cells and larvae suggest that Hr38 plays a role in the ecdysone response, and point to the conclusion that NGFI-B-type receptors may function as heterodimers with RXR-type receptors in regulating transcription.

              (Kozlova et al., 1995)

              Hr38 plays a role in the ecdysone response and that more generally NGFI-B type receptors may be able to function as heterodimers with retinoid receptor type receptors in regulating transcription.

              (Sutherland et al., 1995)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 53 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              PDB - An information portal to biological macromolecular structures
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (16)
              Reported As
              Symbol Synonym
              38E.3
              (Butler, 2001, Butler et al., 2001, McGill Drosophila Genome Project, 2001.9.25)
              38E.7
              (Butler, 2001, Butler et al., 2001, McGill Drosophila Genome Project, 2001.9.25)
              CG1864
              (Buescher et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009)
              DHR38
              (Chng et al., 2017, Mattila and Hietakangas, 2017, Misra et al., 2017, Jaumouillé et al., 2015, Buescher et al., 2013, Hill et al., 2013, Zoglowek et al., 2012, Dubrovsky et al., 2011, Johnston et al., 2011, Ruaud et al., 2011, Sekine et al., 2011, Cui et al., 2009, Kozlova et al., 2009, Lin et al., 2009, Ruaud and Thummel, 2008, Cui et al., 2006, Palanker et al., 2006, Bruey-Sedano et al., 2005, King-Jones and Thummel, 2005, Baker et al., 2003, Privalsky, 2003, Robinow et al., 2001, Baker et al., 2000, Kozlova and Thummel, 2000, Lafont, 2000, Dressel et al., 1999, Nuclear Receptors Nomenclature Committee, 1999, Pokholkova et al., 1999, Crispi et al., 1998, Furia et al., 1998, Komonyi et al., 1998, Kozlova et al., 1996, Sutherland et al., 1996, Fisk, 1995.9.20, Fisk and Thummel, 1995, Kozlova, 1995.6.23, Kozlova et al., 1995, Sutherland et al., 1995)
              Dhr38
              (Fujita et al., 2013, Davis et al., 2007, Gauhar et al., 2005, Semeshin et al., 1999, Kozlova et al., 1998, Kozlova et al., 1998, Kafatos, 1997, Kozlova, 1997.9.24, Kozlova, 1997.10.17, Thummel, 1995)
              HR38
              (Bielska et al., 2012, Fahrbach et al., 2012, Sekine et al., 2011, Spresser et al., 2008, Gritzan et al., 2002, Mink, 1997.11.18)
              Hr38
              (Adhikari et al., 2019, Brunet Avalos et al., 2019, Engel et al., 2019, Shokri et al., 2019, Boardman et al., 2018, Croset et al., 2018, Gene Disruption Project members, 2018-, Lee et al., 2018, Levis, 2018.8.30, Lou et al., 2017, Transgenic RNAi Project members, 2017-, Kalay et al., 2016, Nagy et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, Xie et al., 2015, Ashwal-Fluss et al., 2014, Fujita et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Spokony and White, 2012.5.22, Herranz et al., 2010, Shalaby et al., 2009, Venken et al., 2009, Liu and Lehmann, 2008, Stofanko et al., 2008, Dietzl et al., 2007, Leandro et al., 2007, Minidorff et al., 2007, Stuart et al., 2007, Kamikouchi et al., 2006, Kuranaga et al., 2006, Stroschein-Stevenson et al., 2006, Cirelli et al., 2005)
              NR4A4
              (King-Jones and Thummel, 2005, Nuclear Receptors Nomenclature Committee, 1999)
              dHR38
              (Dziedzic-Letka et al., 2011)
              dhr38
              (Mezan et al., 2016)
              hr38
              (Chen et al., 2016, van Eyk et al., 2011)
              l(2)02306
              Name Synonyms
              Hormone receptor-like in 38
              (Spresser et al., 2008, Stofanko et al., 2008, Morozova et al., 2006)
              hormone receptor 38
              (Dziedzic-Letka et al., 2011)
              hormone receptor-like 38
              (Mezan et al., 2016)
              hormone receptor-like in 38
              (Mosqueira et al., 2010, Kamikouchi et al., 2006)
              Secondary FlyBase IDs
              • FBgn0010510
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (142)