DHR38, 38E.7, 38E.3, NR4A4
nuclear receptor superfamily - participates in a second ecdysteroid signaling pathway that responds to a distinct class of ecdysteroids in a manner that is independent of EcR
Please see the JBrowse view of Dmel\Hr38 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
5.0, 4.0 (northern blot); 2.0 (unknown)
1.9 (northern blot)
5.2 (longest cDNA)
None of the polypeptides share 100% sequence identity.
1073 (aa); 117 (kD predicted)
551 (aa)
Forms a heterodimer with USP.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr38 using the Feature Mapper tool.
The ~5kb Hr38 transcript is detected at all stages by RT-PCR but is very low in early embryos and is most abundant in pupae. It is detected in a third instar larval brain and imaginal disc sample but not in ovaries. The 5kb transcript is enriched in pupae and adults relative to the 4kb transcript.
Comment: >=70 hr APF
GBrowse - Visual display of RNA-Seq signals
View Dmel\Hr38 in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Hr38 CG1864
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Hr38 appears to mediate an atypical Ecdysteroid signalling pathway.
The genomic organisation of the Hr38 locus has been determined and its expression pattern has been analysed.
Hr38 plays an important role in late stages of epidermal morphogenesis.
The results of overexpression in Schneider cells and larvae suggest that Hr38 plays a role in the ecdysone response, and point to the conclusion that NGFI-B-type receptors may function as heterodimers with RXR-type receptors in regulating transcription.
Hr38 plays a role in the ecdysone response and that more generally NGFI-B type receptors may be able to function as heterodimers with retinoid receptor type receptors in regulating transcription.