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Gene Dmel\Mcm2

General Information
Symbol	Dmel\Mcm2	Species	D. melanogaster
Name	Minichromosome maintenance 2	Annotation symbol	CG7538
Feature type	protein_coding_gene	FlyBase ID	FBgn0014861
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	DmMcm2
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	84F6-84F6	Sequence location	3R:4,090,565..4,093,653 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Minichromosome maintenance 2 is referred to in FlyBase by the symbol Dmel\Mcm2 (CG7538, FBgn0014861). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: 3'-5' DNA helicase activity. There is experimental evidence that it is involved in the biological process: lateral inhibition; chromosome condensation; neurogenesis. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; central nervous system; chaeta; nuclear chromosome; imaginal disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Mini-chromosome maintenance complex protein 2; Mini-chromosome maintenance, DNA-dependent ATPase; Mini-chromosome maintenance, conserved site; Nucleic acid-binding, OB-fold; Nucleic acid-binding, OB-fold-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632669_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Mcm2. Gene sequence location is 3R:4090565..4093653.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN21799 HFA16734
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84F6-84F6   Limits computationally determined from genome sequence between P{PZ}grn05930 and P{PZ}Mcm2rL074
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84F6-84F7     (Treisman, 1995.9.29) 84F6-84F7   (determined by in situ hybridisation)   (Spradling et al., 1999) 84F6-84F7     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Treisman, 1995.9.29)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mcm2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mcm2-RA FBtr0081827  NM_057773   3032   887
Additional Transcript Data & Comments
Reported size (kB)	2.8 (compiled cDNA) (Treisman et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mcm2-PA   FBpp0081317   100.4   887   4.74     NP_477121   AAF54207
Additional Polypeptide Data & Comments
Reported size (kDa)	887 (aa) (Treisman et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mini-chromosome maintenance, conserved site (IPR018525) Mini-chromosome maintenance, DNA-dependent ATPase (IPR001208) Mini-chromosome maintenance complex protein 2 (IPR008045) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246545   AA392072   AA392647   AA817224   AA817269   AA820122   AE014297 AAF54207   AC008094   AI515560   AI542220   AQ026366   AW943901   AY069702 AAL39847   BF501325   BF506334   BI165139   BI168490   BI169791   BI170179   BI212279   BI212376   BI214210   BI214333   BI216209   BI230061   BI232178   BI234708   BI236788   BI237672   BI240069   BI358567   BI358727   BI367907   BI372062   BI484958   BI485097   BI486043   BI486067   BI486830   BI579991   BI580340   BI632826   BI633325   BI635329   BI639530   BX008657   CK605116   CK605117   CO284648   CO305716   CO315916   EC212074   EV576382   EV599785   L42762 AAB36617
UniProtKB/Swiss-Prot	P49735
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system   (Treisman et al., 1995) central nervous system   (Treisman et al., 1995) Malpighian tubule   (Treisman et al., 1995) embryonic/larval digestive system   (Treisman et al., 1995) embryonic stage | early     (Treisman et al., 1995) embryonic stage 8   organism | ubiquitous   (Treisman et al., 1995)
Additional Descriptive Data
	Mcm2 transcripts are maternally contributed to the embryo and disappear at cellularization. They are expressed uniformly at germ band extension and are subsequently restricted to a pattern that includes continuous expression in the CNS and transient expression in a number of other tissues, including the Malpighian tubules and the gut. (Treisman et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0014861    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0014861 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0014861 expression level Developmental Stage   Expression Level embryo 00-02hr    10373 embryo 02-04hr    5387 embryo 04-06hr    13849 embryo 06-08hr    8332 embryo 08-10hr    5671 embryo 10-12hr    2607 embryo 12-14hr    1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr    1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day    2807 adult female 05day    5450 adult female 30day    5503 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10373) embryo 02-04hr  (5387) embryo 04-06hr  (13849) embryo 06-08hr  (8332) embryo 08-10hr  (5671) embryo 10-12hr  (2607) embryo 12-14hr  (1442) embryo 14-16hr  (972) embryo 16-18hr  (501) embryo 18-20hr  (316) embryo 20-22hr  (246) embryo 22-24hr  (344) larva L1  (1147) larva L2  (844) larva L3 12hr old  (539) larva L3 puffstage 1-2  (858) larva L3 puffstage 3-6  (952) larva L3 puffstage 7-9  (995) white prepupae new  (786) white prepupae 12hr  (1583) white prepupae 24hr  (992) pupae 2d postWPP  (240) pupae 3d postWPP  (164) pupae 4d postWPP  (390) adult male 01day  (147) adult male 05day  (164) adult male 30day  (179) adult female 01day  (2807) adult female 05day  (5450) adult female 30day  (5503) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10373) embryo 02-04hr  (5387) embryo 04-06hr  (13849) embryo 06-08hr  (8332) embryo 08-10hr  (5671) embryo 10-12hr  (2607) embryo 12-14hr  1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr  (1583) white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day  (2807) adult female 05day  (5450) adult female 30day  (5503) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10373 embryo 02-04hr    5387 embryo 04-06hr  (13849) embryo 06-08hr    8332 embryo 08-10hr    5671 embryo 10-12hr    2607 embryo 12-14hr    1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr    1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day    2807 adult female 05day    5450 adult female 30day    5503 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10373 embryo 02-04hr    5387 embryo 04-06hr    13849 embryo 06-08hr    8332 embryo 08-10hr    5671 embryo 10-12hr    2607 embryo 12-14hr    1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr    1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day    2807 adult female 05day    5450 adult female 30day    5503 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0014861 expression level Developmental Stage   Expression Level embryo 00-02hr    10373 embryo 02-04hr    5387 embryo 04-06hr    13849 embryo 06-08hr    8332 embryo 08-10hr    5671 embryo 10-12hr    2607 embryo 12-14hr    1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr    1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day    2807 adult female 05day    5450 adult female 30day    5503 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10373) embryo 02-04hr  (5387) embryo 04-06hr  (13849) embryo 06-08hr  (8332) embryo 08-10hr  (5671) embryo 10-12hr  (2607) embryo 12-14hr  (1442) embryo 14-16hr  (972) embryo 16-18hr  (501) embryo 18-20hr  (316) embryo 20-22hr  (246) embryo 22-24hr  (344) larva L1  (1147) larva L2  (844) larva L3 12hr old  (539) larva L3 puffstage 1-2  (858) larva L3 puffstage 3-6  (952) larva L3 puffstage 7-9  (995) white prepupae new  (786) white prepupae 12hr  (1583) white prepupae 24hr  (992) pupae 2d postWPP  (240) pupae 3d postWPP  (164) pupae 4d postWPP  (390) adult male 01day  (147) adult male 05day  (164) adult male 30day  (179) adult female 01day  (2807) adult female 05day  (5450) adult female 30day  (5503) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10373) embryo 02-04hr  (5387) embryo 04-06hr  (13849) embryo 06-08hr  (8332) embryo 08-10hr  (5671) embryo 10-12hr  (2607) embryo 12-14hr  1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr  1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day  (2807) adult female 05day  (5450) adult female 30day  (5503) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10373 embryo 02-04hr    5387 embryo 04-06hr  13849 embryo 06-08hr    8332 embryo 08-10hr    5671 embryo 10-12hr    2607 embryo 12-14hr    1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr    1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day    2807 adult female 05day    5450 adult female 30day    5503 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10373 embryo 02-04hr    5387 embryo 04-06hr    13849 embryo 06-08hr    8332 embryo 08-10hr    5671 embryo 10-12hr    2607 embryo 12-14hr    1442 embryo 14-16hr    972 embryo 16-18hr    501 embryo 18-20hr    316 embryo 20-22hr    246 embryo 22-24hr    344 larva L1    1147 larva L2    844 larva L3 12hr old    539 larva L3 puffstage 1-2    858 larva L3 puffstage 3-6    952 larva L3 puffstage 7-9    995 white prepupae new    786 white prepupae 12hr    1583 white prepupae 24hr    992 pupae 2d postWPP    240 pupae 3d postWPP    164 pupae 4d postWPP    390 adult male 01day    147 adult male 05day    164 adult male 30day    179 adult female 01day    2807 adult female 05day    5450 adult female 30day    5503 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0014861    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0014861 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0014861 expression level Tissue   Expression Level Larval Central Nervous System    594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    894.5 Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (594.225) Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary  (894.5) Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    894.5 Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    894.5 Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0014861 expression level Tissue   Expression Level Larval Central Nervous System    594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    894.5 Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary  (894.5) Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    894.5 Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    594.225 Larval Midgut    29.7 Larval Hindgut    80.8 Larval Malpighian Tubules    20.7 Larval Fat Body    33.4 Larval Salivary Gland    195.6 Larval Trachea    201.775 Larval Carcass    142.15 Adult Head    29.1 Adult Eye    13.15 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    27.5 Adult Midgut    25.6 Adult Hindgut    16.3 Adult Malpighian Tubules    21.8 Adult Fat Body    23 Adult Salivary Gland no informative data Adult Heart    16.525 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    894.5 Adult Testis    27.3 Adult Male Accessory Gland    16.2 Adult Carcass    35.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    29.1   NA  Eye    13.15   NA  Brain    4   594.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    8   NA  Crop    27.5   29.7  Midgut    25.6   80.8  Hindgut    16.3   20.7  Malpighian Tubules    21.8   33.4  Fat Body    23   195.6  Salivary Gland    no informative data   NA  Heart    16.525   201.775  Trachea    NA   NA  VirginFemale Spermatheca    17.8   NA  InseminatedFemale Spermatheca    22.5   NA  Ovary    894.5   NA  Testis    27.3   NA  Male Accessory Gland    16.2   142.15  Carcass    35.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014861 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7538-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mcm2 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Mcm2GD4467 lethal | adult stage | recessive Mcm2rL074 lethal | recessive Mcm2rL074 viable, with Scer\GAL4pnr-MD237 Mcm2GD4467 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Mcm2GD4467 visible, with Scer\GAL4pnr-MD237 Mcm2GD4467 Phenotype manifest in Allele central nervous system Mcm2rL074 chaeta, with Scer\GAL4pnr-MD237 Mcm2GD4467 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Mcm2GD4467 ganglion mother cell | larval stage, with Scer\GAL41407 Mcm2GD4467 imaginal disc Mcm2rL074 nuclear chromosome Mcm2dsRNA.cCa trichogen cell, with Scer\GAL4pnr-MD237 Mcm2GD4467
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Mcm2 Class Mutagen Stocks Known lesion Mcm2rL074 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mcm2 Class Mutagen Stocks Known lesion Mcm2GD4467 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mcm2HMS01520 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mcm2KK101748 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mcm2dsRNA.cCa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)ED5296 (Ryder and Roote, 2004.11.10) Df(3R)Exel6147 (Ryder, 2004.4.26) Df(3R)p712 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4467} NA P{KK101748} NA P{TRiP.HMS01520} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Mcm2rL074 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
contributes_to 3'-5' DNA helicase activity inferred from direct assay (Moyer et al., 2006)
Biological Process
CV term Evidence References
chromosome condensation inferred from mutant phenotype (Christensen and Tye, 2003) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001208, InterPro:IPR008045, InterPro:IPR018525 (FlyBase Curators et al., 2004-) chromatin binding inferred from sequence or structural similarity with Saccharomyces MCM2 (FlyBase, 1992-) non-traceable author statement (Treisman, 1995.9.29) DNA binding inferred from electronic annotation with InterPro:IPR001208, InterPro:IPR008045, InterPro:IPR018525 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Biological Process
CV term Evidence References
cell proliferation non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) DNA-dependent DNA replication initiation inferred from electronic annotation with InterPro:IPR008045 (FlyBase Curators et al., 2004-) DNA replication non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) traceable author statement (Lee and Orr-Weaver, 2003) pre-replicative complex assembly inferred from sequence or structural similarity with Saccharomyces MCM2 (FlyBase, 1992-) non-traceable author statement (Treisman, 1995.9.29)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) pre-replicative complex inferred from sequence or structural similarity with Saccharomyces MCM2 (FlyBase, 1992-) non-traceable author statement (Treisman, 1995.9.29)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mcm2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66154 DroID - A comprehensive database of gene and protein interactions. • FBgn0014861 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40973
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18817 Dere\GG24143 Dgri\GH14181 Dmoj\GI22091 Dper\GL23360 Dpse\GA20424 Dsec\GM23713 Dsim\GD18528 Dvir\GJ24206 Dwil\GK11732 Dyak\GE25859
Curated drosophilid orthologs	Dpse\GA20424
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007007-PA Aedes aegypti (mosquito) AGAP004275-PA Anopheles gambiae (mosquito) XP_395109.2 Apis mellifera (honey bee) XP_001944886.1 Acyrthosiphon pisum (pea aphid) At1g44900.1 Arabidopsis thaliana (wall cress) 19082 Batrachochytrium dendrobatidis (chytrid fungus) 277766 Branchiostoma floridae (lancelet) XP_001900869.1 Brugia malayi (roundworm nematode) BGIBMGA008625-PA Bombyx mori (silk worm) ENSBTAP00000019121 Bos taurus (bovine) CAL0001039 Candida albicans (a form of yeast) CN27777 Caenorhabditis brenneri (small nematode) CBP29236 Caenorhabditis briggsae (nematode) CE19038 Caenorhabditis elegans (worm) ENSCAFP00000006027 Canis familiaris (dog) CAGL0J04444g Candida glabrata (haploid yeast) Chro.20122 Cryptosporidium hominis (obligate parasite) JA18313 Caenorhabditis japonica (nematode) CMD025C Cyanidioschyzon merolae (red alga) cn07240 Cryptococcus neoformans (yeast-like fungus) cgd2_1100 Cryptosporidium parvum (protozoan parasite) CPIJ002555 Culex pipens (mosquito) ENSCPOP00000009081 Cavia porcellus (guinea pig) 152683 Chlamidomonas reinhardtii (green alga) RP42105 Caenorhabditis remanei (nematode) ENSCSAVP00000009783 Ciona savignyi (sedentary tunicate) 175811 Capitella spl (polychaete worm) DDB0232353 Dictyostelium discoideum (amoeba) DEHA2F21494g Debaryomyces Hansenii (yeast) 306072 Daphnia pulex (daphnia) ENSDARP00000049625 Danio rerio (zebra fish) ENSECAP00000017451 Equus caballus (horse) XP_656059 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000041 Gymnopilus aculeatus (mushroom) ENSGALP00000009709 Gallus gallus (chicken) GL50803_15344 Giardia lamblia (flagellated protozoan) 191161 Hypsipyla robusta (cedar shoot borer) ENSP00000265056 Homo sapiens (human) ISCW016696-PA Ixodes scapularis (deer tick) KLLA0F12584g Kluyveromyces lactis (yeast) 168864 Lottia gigantea (owl limpet) LmjF28.0850 Leishmania major (virus) 36175 Monocosta brevicollis (choanoflagellate) ENSMODP00000009819 Monodelphis domestica (gray opossum) ENSMMUP00000000221 Macaca mulatta (rhesus monkey) ENSMUSP00000061923 Mus musculus (house mouse) 191344 Nematostella vectensis (starlet anemone) XP_001603896.1 Nasonia vitripennis (wasp) ENSOANP00000011401 Ornithorynchus anatinus (platypus) ENSORLP00000003973 Oryzias latipes (japanese killifish) LOC_Os11g29380.1 Oryza sativa (asian rice) 35447 Ostreococcus tauri (green alga) PF14_0177 Plasmodium falciparum (protozoal parasite) PHUM005773-PA Pediculus humanus (human body louse) 178124 Physcomitrella patens (moss) ENSPPYP00000015037 Pongo pygmaeus (orangutan) 72188 Phytophthora ramorum (sudden oak death pathogen) 119846 Phytophthora sojae (root rot pathogen) 179437 Populus trichocarpa (black cottonwood) ENSPTRP00000026448 Pan troglodytes (chimpanzee) PVX_085565 Plasmodium vivax (protozoal parasite) ENSRNOP00000022231 Rattus norvegicus (norway rat) 4865958 Sorghum bicolor (sorghum) YBL023C Saccharomyces cerevisiae (budding yeast) Smp_079560 Schistosoma mansoni (trematode parasite) SPBC4.04c Schizosaccharomyces pombe (fission yeast) XP_784985.2 Strongylocentrotus purpuratus (purple sea urchin) 63837 Trichoplax adhaerens (metazoa) TA13680 Theileria annulata (apicomplexan parasite) XP_970643.2 Tribolium castaneum (red flour beetle) Tc00.1047053506933.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020635 Tetraodon nigroviridis (green spotted pufferfish) TP02_0532 Theileria parva (parasitic protozoan) 29936 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018074 Takifugu rubripes (pufferfish Takifugu) 72.m00157 Tetrahymena thermophila (ciliate protozoa) 84302.m00265 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000004403 Xenopus tropicalis (frog) YALI0F04664g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16782 NV14878 LH13561 ISCW016696 FBgn0242909 FBgn0213743 FBgn0211289 FBgn0190051 FBgn0178578 JGI_V11_306072 FBgn0080419 FBgn0160950 FBgn0144820 FBgn0121657 FBgn0116276 FBgn0095834 CPIJ002555 BGIBMGA008625 ACYPI003255 GB18195 AGAP012691 AGAP004275 AAEL007007 PHUM492170 GLEAN_11437
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	12122 ry506 P{PZ}Mcm2rL074/TM3, Sb1 35771 y1 sc* v1; P{TRiP.HMS01520}attP2
VDRC	v103619 P{KK101748}VIE-260B v10967 w1118; P{GD4467}v10967/TM3
Genomic Clones ( 1 )
	BACR45A07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47441
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08777 AT16614 LD05520 LD11544 LD12882 LD22409 LD22491 LD22753 RE04961 RE09242 RE11066 RE11557 RE17338 RE17451 RE19948 RE20110 RE23151 RE27987 RE28203 RE30456 RE32907 RE33942 RE36716 RE37052 RE45379 RE53779 RE57843 RE68155 RE68370 RE69415 RE69439 RE70305 RE74107 RE74521 SD08372 SD16641 SD22130 SD26707 SD27388
Other clones	Dmel_dig_001933_0704_1415 Dmel_neb_014114_0907_2183 EK166462 EK249307 EK263101 UT01689
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014861 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40973
Antibody Information
Other Information
Discoverer
	G. Rubin.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mcm2 CG7538 (Zhao, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The Sld5, Psf1, Psf2, Psf3, CDC45L, Mcm2, Mcm3, Mcm5, Mcm6, Mcm7 and dpa proteins form the Cdc45/Mcm2-7/GINS (CMG) complex, a helicase required for the S phase transition in Kc cells. (Moyer et al., 2006) CycE protein can drive chromosome association of Mcm2 in polytene nuclei and DNA synthesis erases this association. (Su and O'Farrell, 1998) Physical interactions exist between three MCM proteins, dpa, Mcm2 and Mcm5. The three proteins reside predominantly in stable multi-protein complexes of about 600kD. Coimmunoprecipitation experiments indicate there are at least two distinct 600kD complexes, one of which includes Mcm5 and the other dpa. (Su et al., 1996) For the yeast genes MCM stands for 'minichromosome maintenance'. (Treisman et al., 1995) Mcm2 plays a role in the regulation of DNA replication analogous to that of its yeast counterpart (MCM2). (Treisman et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057773 RefSeq (Proteins) • NP_477121 DDBJ / EMBL / GenBank • AA246545 AAB36617 AAF54207 AAL39847 AC008094 AI515560 AQ026366 AW943901 AY069702 L42762 Entrez Gene - A searchable database of RefSeq genes. • 40973 UniProtKB/Swiss-Prot • P49735
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mini-chromosome maintenance, conserved site (IPR018525) Mini-chromosome maintenance, DNA-dependent ATPase (IPR001208) Mini-chromosome maintenance complex protein 2 (IPR008045) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66154 DroID - A comprehensive database of gene and protein interactions. • FBgn0014861 DRSC - Results from RNAi screens. • FBgn0014861 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014861 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7538-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014861 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40973 InParanoid A subset of ortholog calls from InParanoid. • AAEL007007-PA Aedes aegypti (mosquito) AGAP004275-PA Anopheles gambiae (mosquito) XP_395109.2 Apis mellifera (honey bee) XP_001944886.1 Acyrthosiphon pisum (pea aphid) At1g44900.1 Arabidopsis thaliana (wall cress) 19082 Batrachochytrium dendrobatidis (chytrid fungus) 277766 Branchiostoma floridae (lancelet) XP_001900869.1 Brugia malayi (roundworm nematode) BGIBMGA008625-PA Bombyx mori (silk worm) ENSBTAP00000019121 Bos taurus (bovine) CAL0001039 Candida albicans (a form of yeast) CN27777 Caenorhabditis brenneri (small nematode) CBP29236 Caenorhabditis briggsae (nematode) CE19038 Caenorhabditis elegans (worm) ENSCAFP00000006027 Canis familiaris (dog) CAGL0J04444g Candida glabrata (haploid yeast) Chro.20122 Cryptosporidium hominis (obligate parasite) JA18313 Caenorhabditis japonica (nematode) CMD025C Cyanidioschyzon merolae (red alga) cn07240 Cryptococcus neoformans (yeast-like fungus) cgd2_1100 Cryptosporidium parvum (protozoan parasite) CPIJ002555 Culex pipens (mosquito) ENSCPOP00000009081 Cavia porcellus (guinea pig) 152683 Chlamidomonas reinhardtii (green alga) RP42105 Caenorhabditis remanei (nematode) ENSCSAVP00000009783 Ciona savignyi (sedentary tunicate) 175811 Capitella spl (polychaete worm) DDB0232353 Dictyostelium discoideum (amoeba) DEHA2F21494g Debaryomyces Hansenii (yeast) 306072 Daphnia pulex (daphnia) ENSDARP00000049625 Danio rerio (zebra fish) ENSECAP00000017451 Equus caballus (horse) XP_656059 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000041 Gymnopilus aculeatus (mushroom) ENSGALP00000009709 Gallus gallus (chicken) GL50803_15344 Giardia lamblia (flagellated protozoan) 191161 Hypsipyla robusta (cedar shoot borer) ENSP00000265056 Homo sapiens (human) ISCW016696-PA Ixodes scapularis (deer tick) KLLA0F12584g Kluyveromyces lactis (yeast) 168864 Lottia gigantea (owl limpet) LmjF28.0850 Leishmania major (virus) 36175 Monocosta brevicollis (choanoflagellate) ENSMODP00000009819 Monodelphis domestica (gray opossum) ENSMMUP00000000221 Macaca mulatta (rhesus monkey) ENSMUSP00000061923 Mus musculus (house mouse) 191344 Nematostella vectensis (starlet anemone) XP_001603896.1 Nasonia vitripennis (wasp) ENSOANP00000011401 Ornithorynchus anatinus (platypus) ENSORLP00000003973 Oryzias latipes (japanese killifish) LOC_Os11g29380.1 Oryza sativa (asian rice) 35447 Ostreococcus tauri (green alga) PF14_0177 Plasmodium falciparum (protozoal parasite) PHUM005773-PA Pediculus humanus (human body louse) 178124 Physcomitrella patens (moss) ENSPPYP00000015037 Pongo pygmaeus (orangutan) 72188 Phytophthora ramorum (sudden oak death pathogen) 119846 Phytophthora sojae (root rot pathogen) 179437 Populus trichocarpa (black cottonwood) ENSPTRP00000026448 Pan troglodytes (chimpanzee) PVX_085565 Plasmodium vivax (protozoal parasite) ENSRNOP00000022231 Rattus norvegicus (norway rat) 4865958 Sorghum bicolor (sorghum) YBL023C Saccharomyces cerevisiae (budding yeast) Smp_079560 Schistosoma mansoni (trematode parasite) SPBC4.04c Schizosaccharomyces pombe (fission yeast) XP_784985.2 Strongylocentrotus purpuratus (purple sea urchin) 63837 Trichoplax adhaerens (metazoa) TA13680 Theileria annulata (apicomplexan parasite) XP_970643.2 Tribolium castaneum (red flour beetle) Tc00.1047053506933.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020635 Tetraodon nigroviridis (green spotted pufferfish) TP02_0532 Theileria parva (parasitic protozoan) 29936 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018074 Takifugu rubripes (pufferfish Takifugu) 72.m00157 Tetrahymena thermophila (ciliate protozoa) 84302.m00265 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000004403 Xenopus tropicalis (frog) YALI0F04664g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40973 modMine - Data generated by the modENCODE project. • FBgn0014861 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16782 NV14878 LH13561 ISCW016696 FBgn0242909 FBgn0213743 FBgn0211289 FBgn0190051 FBgn0178578 JGI_V11_306072 FBgn0080419 FBgn0160950 FBgn0144820 FBgn0121657 FBgn0116276 FBgn0095834 CPIJ002555 BGIBMGA008625 ACYPI003255 GB18195 AGAP012691 AGAP004275 AAEL007007 PHUM492170 GLEAN_11437
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG7538 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dMCM2 (Burke et al., 2001) DmeMCM2 (Blanton et al., 2005) DmMcm2 (Loebel et al., 2000) DmMCM2 (Ohno et al., 1998, Kearsey and Labib, 1998, Su and O'Farrell, 1998, Su and O'Farrell, 1997, Su et al., 1997, Su et al., 1996, Treisman et al., 1995) l(3)rL074   MCM2 (Claycomb et al., 2002, Lee and Orr-Weaver, 2003, Crevel et al., 2001, Treisman, 1995.9.29, Feger, 1999, Crevel et al., 2007, Hong et al., 2007, Moshkin et al., 2009, Ilves et al., 2010, Lemos et al., 2010, Apger et al., 2010) Mcm2 (Moyer et al., 2006, Foglietti et al., 2006, Cayirlioglu et al., 2003, Gosnell and Christensen, 2011, Orihara-Ono et al., 2011, Neumüller et al., 2011) McM2 (De Lucia et al., 2005) MCM2-7 (Macalpine et al., 2010) MCM2_DROME (Storm and Sonnhammer, 2003) PCR3 (Su et al., 1997) unnamed (Treisman and Rubin, 1996)
Name Synonym	Minichromosome maintenance 2 (Fernandez-Costa and Artero, 2010)
Secondary FlyBase IDs
	FBgn0011511
References ( 62 )
Generate a list of	All references relating to this gene ( 62 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 4 ) Review  ( 5 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 8 )
	Gosnell and Christensen, 2011, BMC Mol. Biol. 12: 13 Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression. [FBrf0213597] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Orihara-Ono et al., 2011, Dev. Biol. 351(1): 163--175 Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1. [FBrf0212978] Apger et al., 2010, Genetics 185(4): 1151--1165 Multiple functions for Drosophila mcm10 suggested through analysis of two mcm10 mutant alleles. [FBrf0211525] Fernandez-Costa and Artero, 2010, Mol. Cells 30(1): 65--70 A conserved motif controls nuclear localization of Drosophila Muscleblind. [FBrf0211364] Ilves et al., 2010, Mol. Cell 37(2): 247--258 Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins. [FBrf0209843] Lemos et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15826--15831 Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. [FBrf0211775] Macalpine et al., 2010, Genome Res. 20(2): 201--211 Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. [FBrf0209851] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...