Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Gene model reviewed during 6.02
2.3 (northern blot)
495 (aa); 53 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mlp84B using the Feature Mapper tool.
Mlp84B transcripts are first detected by northern blot analysis in 8-12hr embryos, peak in 16-24hr embryos, are present in low levels in larvae, show a second peak of expression at the larval to pupal transition, and persist in adults. They are detected by in situ hybridization starting in embryonic stage 14 in the growing syncytial myotubes. They are present in the completed pattern of somatic muscles in stage 16 embryos. Mlp84B transcripts are concentrated at the terminal portions of the myotubes near where they are making attachments to the epidermis. Transcripts are also expressed in the visceral mesoderm and the pharyngeal muscle. In contrast to the somatic muscle, the distribution of transcripts is not polarized in these locations.
Mlp84B protein is detected beginning in stage 14 embryos in somatic, visceral and pharyngeal muscles. Protein is found throughout the myotube but is more concentrated at the ends of muscle fibers at the point of attachment to the epidermis. Mlp84B protein appears to associate with linear cytoplasmic elements in the muscle cell syncytium that are thought to be the sarcomeric actin filament network.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mlp84B in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Mlp84B CG1019
Mlp84B protein is identified and developmental expression pattern determined. Results reveal a striking conservation of sequence, timing of gene expression, tissue distribution of gene products and subcellular localisation among LIM proteins of vertebrates and invertebrates.
Protein has five LIM domains and is expressed in the muscle.