Metch, DIM 17
Please see the JBrowse view of Dmel\Mtk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Gene model reviewed during 5.44
Gene model reviewed during 5.56
0.268 (sequence analysis)
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mtk using the Feature Mapper tool.
Comment: reference states 6-24 hr AEL
Mtk transcripts are expressed in embryos, and they are expressed in response to immunization with both gram positive and gram negative bacteria, up to 120 hours post immunization.
Mtk protein is induced in hemolymph after bacterial challenge. Time course studies with mass spectrometric analysis show that it is detectable within 6 hours of the challenge, increases substantially between 6hrs and 2 weeks, and is gone by 3 weeks after challenge.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Mtk in GBrowse 22-74
2-78.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Mtk BcDNA:RH07954
Source for merge of Mtk BcDNA:RH07954 was a shared cDNA ( date:030728 ).
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
Identification: Encodes a protein that is induced by immune challenge.
Ecol\lacZDpt.PR adults are pricked with a sterile needle dipped in culture pellets of various living microorganisms (distinct bacterial strains, fungal spores or hyphae). Pricking results in a low but clearly detectable expression of all antimicrobial genes and these genes are induced above the background level by specific classes of microorganism. Wild type adults covered with spores of B.bassiana induce persistent expression of Mtk.
Mtk, a gene encoding a proline-rich immune-inducible peptide, has been cloned and sequenced.
The gene is named 'Metchnikowin' in honour of E. Metchnikow who initiated the field of research into invertebrate immunity.