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Gene Dmel\Roe1

General Information
Symbol	Dmel\Roe1	Species	D. melanogaster
Name	Roe1	Annotation symbol	CG6155
Feature type	protein_coding_gene	FlyBase ID	FBgn0014877
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	DROE1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50B1-50B1	Sequence location	2R:9,441,587..9,443,111 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Roe1 is referred to in FlyBase by the symbol Dmel\Roe1 (CG6155, FBgn0014877). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: unfolded protein binding. There is experimental evidence that it is involved in the biological process: neurogenesis. One allele is reported. The phenotype of this allele is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: GrpE nucleotide exchange factor; GrpE nucleotide exchange factor, coiled-coil; GrpE nucleotide exchange factor, head. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, adult fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626002_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Roe1. Gene sequence location is 2R:9441587..9443111.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN45550 BKN20471 HFA07534
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50B1-50B1   Limits computationally determined from genome sequence between P{lacW}drkk13809&P{EP}mip120EP606 and P{lacW}l(2)03105k16702&P{lacW}fl(2)dk16105
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Roe1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Roe1-RA FBtr0087675  NM_137042   1060   213
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Roe1-PA   FBpp0086795   23.9   213   8.80     NP_610886   AAF58354
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GrpE nucleotide exchange factor (IPR000740) GrpE nucleotide exchange factor, head (IPR009012) GrpE nucleotide exchange factor, coiled-coil (IPR013805) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06155
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803263   AE013599 AAF58354   AY060856   AY094889 AAM11242   BE976600   BE976883   BE977323   BE977735   BE978335   BF485605   BF496168   BF504470   BF504910   BF506708   BG635183   BI169366   BI236534   BI355963   BI370100   BI580762   BI591923   BI608751   BP542715   BP543132   BP545781   BP546055   BP546605   BP556078   BP559517   BT050467   CO272426   CO275290   CO298496   CO314153   EC072149   EC073544   EC201314   EC208927   EC209039   EC210763   EC212021   EC237342   EC250921   EL885504   EL885631   EL885871   EV576637   EV578521   GH750224   GH752119   GH752944   GH755884   GH761212   GH774614   GH774797   GH775494   GH776548   GH785115   GH787411   GH788452   GH788931   GH795285   GH795714   GH796356   GH797072   GH798092   GH799497   GH800719   GH801648   GH802436   GH802702   GH802758   GH804737   GH807986   GH808555   GH810814   GH811167   GH812958   GH813048   GH814533   GH815140   GH815852   GH818168   GH818243   GH818409   GH818566   GH818685   GH819962   GH820247   GH820681   GH821430   GH823268   GH824128   GH825803   GH827136   GH828360   GH828971   GH831206   GH831747   GH833477   GH834941   GH840723   GH840886   GH841346   GH842420   GH843114   GH846100   GH846243   GH847683   GH854021   GH855116   GH857017   GH857626   GH864879   GH867354   GH869860   GH871575   GH871634   GH876190   GH876716   GH877433   GH879538   GH882980   GH883022   GH883982   GH885568   GH886185   GH889708   GH889984   GH891285   GH892276   GH892711   GH893359   GH895896   GH895911   GH896051   GH900444   GH901721   GH902247   GH902821   GH905849   GH907303   GH910039   GH910083   GH913154   GH913275   GH913782   GH914474   GH914719   GH915849   GH921631   GH922108   GH923582   GH923653   GH926471   GH926600   GH929797   GH930248   GH931363   GH931532   GH932921   GH933263   GH933413   GH934382   GH936618   GH937706   GH940275   GH940560   U34903 AAA79044
UniProtKB/Swiss-Prot	P48604
UniProtKB/TrEMBL	Q95SD0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0014877    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0014877 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0014877 expression level Developmental Stage   Expression Level embryo 00-02hr    6716 embryo 02-04hr    1521 embryo 04-06hr    1977 embryo 06-08hr    3217 embryo 08-10hr    3715 embryo 10-12hr    7442 embryo 12-14hr    5975 embryo 14-16hr    4897 embryo 16-18hr    5734 embryo 18-20hr    5134 embryo 20-22hr    5251 embryo 22-24hr    4776 larva L1    7209 larva L2    6845 larva L3 12hr old    4991 larva L3 puffstage 1-2    1786 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    2304 white prepupae new    1992 white prepupae 12hr    2482 white prepupae 24hr    3365 pupae 2d postWPP    5088 pupae 3d postWPP    4964 pupae 4d postWPP    3427 adult male 01day    5576 adult male 05day    7003 adult male 30day    5431 adult female 01day    3183 adult female 05day    5405 adult female 30day    5823 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6716) embryo 02-04hr  (1521) embryo 04-06hr  (1977) embryo 06-08hr  (3217) embryo 08-10hr  (3715) embryo 10-12hr  (7442) embryo 12-14hr  (5975) embryo 14-16hr  (4897) embryo 16-18hr  (5734) embryo 18-20hr  (5134) embryo 20-22hr  (5251) embryo 22-24hr  (4776) larva L1  (7209) larva L2  (6845) larva L3 12hr old  (4991) larva L3 puffstage 1-2  (1786) larva L3 puffstage 3-6  (1966) larva L3 puffstage 7-9  (2304) white prepupae new  (1992) white prepupae 12hr  (2482) white prepupae 24hr  (3365) pupae 2d postWPP  (5088) pupae 3d postWPP  (4964) pupae 4d postWPP  (3427) adult male 01day  (5576) adult male 05day  (7003) adult male 30day  (5431) adult female 01day  (3183) adult female 05day  (5405) adult female 30day  (5823) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6716) embryo 02-04hr  (1521) embryo 04-06hr  (1977) embryo 06-08hr  (3217) embryo 08-10hr  (3715) embryo 10-12hr  (7442) embryo 12-14hr  (5975) embryo 14-16hr  (4897) embryo 16-18hr  (5734) embryo 18-20hr  (5134) embryo 20-22hr  (5251) embryo 22-24hr  (4776) larva L1  (7209) larva L2  (6845) larva L3 12hr old  (4991) larva L3 puffstage 1-2  (1786) larva L3 puffstage 3-6  (1966) larva L3 puffstage 7-9  (2304) white prepupae new  (1992) white prepupae 12hr  (2482) white prepupae 24hr  (3365) pupae 2d postWPP  (5088) pupae 3d postWPP  (4964) pupae 4d postWPP  (3427) adult male 01day  (5576) adult male 05day  (7003) adult male 30day  (5431) adult female 01day  (3183) adult female 05day  (5405) adult female 30day  (5823) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6716 embryo 02-04hr    1521 embryo 04-06hr    1977 embryo 06-08hr    3217 embryo 08-10hr    3715 embryo 10-12hr    7442 embryo 12-14hr    5975 embryo 14-16hr    4897 embryo 16-18hr    5734 embryo 18-20hr    5134 embryo 20-22hr    5251 embryo 22-24hr    4776 larva L1    7209 larva L2    6845 larva L3 12hr old    4991 larva L3 puffstage 1-2    1786 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    2304 white prepupae new    1992 white prepupae 12hr    2482 white prepupae 24hr    3365 pupae 2d postWPP    5088 pupae 3d postWPP    4964 pupae 4d postWPP    3427 adult male 01day    5576 adult male 05day    7003 adult male 30day    5431 adult female 01day    3183 adult female 05day    5405 adult female 30day    5823 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6716 embryo 02-04hr    1521 embryo 04-06hr    1977 embryo 06-08hr    3217 embryo 08-10hr    3715 embryo 10-12hr    7442 embryo 12-14hr    5975 embryo 14-16hr    4897 embryo 16-18hr    5734 embryo 18-20hr    5134 embryo 20-22hr    5251 embryo 22-24hr    4776 larva L1    7209 larva L2    6845 larva L3 12hr old    4991 larva L3 puffstage 1-2    1786 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    2304 white prepupae new    1992 white prepupae 12hr    2482 white prepupae 24hr    3365 pupae 2d postWPP    5088 pupae 3d postWPP    4964 pupae 4d postWPP    3427 adult male 01day    5576 adult male 05day    7003 adult male 30day    5431 adult female 01day    3183 adult female 05day    5405 adult female 30day    5823 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0014877 expression level Developmental Stage   Expression Level embryo 00-02hr    6716 embryo 02-04hr    1521 embryo 04-06hr    1977 embryo 06-08hr    3217 embryo 08-10hr    3715 embryo 10-12hr    7442 embryo 12-14hr    5975 embryo 14-16hr    4897 embryo 16-18hr    5734 embryo 18-20hr    5134 embryo 20-22hr    5251 embryo 22-24hr    4776 larva L1    7209 larva L2    6845 larva L3 12hr old    4991 larva L3 puffstage 1-2    1786 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    2304 white prepupae new    1992 white prepupae 12hr    2482 white prepupae 24hr    3365 pupae 2d postWPP    5088 pupae 3d postWPP    4964 pupae 4d postWPP    3427 adult male 01day    5576 adult male 05day    7003 adult male 30day    5431 adult female 01day    3183 adult female 05day    5405 adult female 30day    5823 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6716) embryo 02-04hr  (1521) embryo 04-06hr  (1977) embryo 06-08hr  (3217) embryo 08-10hr  (3715) embryo 10-12hr  (7442) embryo 12-14hr  (5975) embryo 14-16hr  (4897) embryo 16-18hr  (5734) embryo 18-20hr  (5134) embryo 20-22hr  (5251) embryo 22-24hr  (4776) larva L1  (7209) larva L2  (6845) larva L3 12hr old  (4991) larva L3 puffstage 1-2  (1786) larva L3 puffstage 3-6  (1966) larva L3 puffstage 7-9  (2304) white prepupae new  (1992) white prepupae 12hr  (2482) white prepupae 24hr  (3365) pupae 2d postWPP  (5088) pupae 3d postWPP  (4964) pupae 4d postWPP  (3427) adult male 01day  (5576) adult male 05day  (7003) adult male 30day  (5431) adult female 01day  (3183) adult female 05day  (5405) adult female 30day  (5823) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6716) embryo 02-04hr  1521 embryo 04-06hr  1977 embryo 06-08hr  (3217) embryo 08-10hr  (3715) embryo 10-12hr  (7442) embryo 12-14hr  (5975) embryo 14-16hr  (4897) embryo 16-18hr  (5734) embryo 18-20hr  (5134) embryo 20-22hr  (5251) embryo 22-24hr  (4776) larva L1  (7209) larva L2  (6845) larva L3 12hr old  (4991) larva L3 puffstage 1-2  1786 larva L3 puffstage 3-6  1966 larva L3 puffstage 7-9  2304 white prepupae new  1992 white prepupae 12hr  (2482) white prepupae 24hr  (3365) pupae 2d postWPP  (5088) pupae 3d postWPP  (4964) pupae 4d postWPP  (3427) adult male 01day  (5576) adult male 05day  (7003) adult male 30day  (5431) adult female 01day  (3183) adult female 05day  (5405) adult female 30day  (5823) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6716 embryo 02-04hr    1521 embryo 04-06hr    1977 embryo 06-08hr    3217 embryo 08-10hr    3715 embryo 10-12hr    7442 embryo 12-14hr    5975 embryo 14-16hr    4897 embryo 16-18hr    5734 embryo 18-20hr    5134 embryo 20-22hr    5251 embryo 22-24hr    4776 larva L1    7209 larva L2    6845 larva L3 12hr old    4991 larva L3 puffstage 1-2    1786 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    2304 white prepupae new    1992 white prepupae 12hr    2482 white prepupae 24hr    3365 pupae 2d postWPP    5088 pupae 3d postWPP    4964 pupae 4d postWPP    3427 adult male 01day    5576 adult male 05day    7003 adult male 30day    5431 adult female 01day    3183 adult female 05day    5405 adult female 30day    5823 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6716 embryo 02-04hr    1521 embryo 04-06hr    1977 embryo 06-08hr    3217 embryo 08-10hr    3715 embryo 10-12hr    7442 embryo 12-14hr    5975 embryo 14-16hr    4897 embryo 16-18hr    5734 embryo 18-20hr    5134 embryo 20-22hr    5251 embryo 22-24hr    4776 larva L1    7209 larva L2    6845 larva L3 12hr old    4991 larva L3 puffstage 1-2    1786 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    2304 white prepupae new    1992 white prepupae 12hr    2482 white prepupae 24hr    3365 pupae 2d postWPP    5088 pupae 3d postWPP    4964 pupae 4d postWPP    3427 adult male 01day    5576 adult male 05day    7003 adult male 30day    5431 adult female 01day    3183 adult female 05day    5405 adult female 30day    5823 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0014877    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0014877 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, adult fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0014877 expression level Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0014877 expression level Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    54.65 Larval Midgut    127.5 Larval Hindgut    150.3 Larval Malpighian Tubules    26.7 Larval Fat Body    53.9 Larval Salivary Gland    186.7 Larval Trachea    81.95 Larval Carcass    109.175 Adult Head    56.8 Adult Eye    47.375 Adult Brain    63.9 Adult Thoracic-Abdominal Ganglion    91.9 Adult Crop    49.4 Adult Midgut    57 Adult Hindgut    46.5 Adult Malpighian Tubules    83.8 Adult Fat Body    137.2 Adult Salivary Gland    127.1 Adult Heart    69.95 Adult VirginFemale Spermatheca    78.9 Adult InseminatedFemale Spermatheca    100.4 Adult Ovary    123.5 Adult Testis    468.8 Adult Male Accessory Gland    110.5 Adult Carcass    134.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    56.8   NA  Eye    47.375   NA  Brain    63.9   54.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    91.9   NA  Crop    49.4   127.5  Midgut    57   150.3  Hindgut    46.5   26.7  Malpighian Tubules    83.8   53.9  Fat Body    137.2   186.7  Salivary Gland    127.1   NA  Heart    69.95   81.95  Trachea    NA   NA  VirginFemale Spermatheca    78.9   NA  InseminatedFemale Spermatheca    100.4   NA  Ovary    123.5   NA  Testis    468.8   NA  Male Accessory Gland    110.5   109.175  Carcass    134.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014877 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6155-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Roe1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Roe1GD10561 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Roe1GD10561 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Roe1GD10561 visible, with Scer\GAL4pnr-MD237 Roe1GD10561 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Roe1GD10561 ganglion mother cell | larval stage, with Scer\GAL41407 Roe1GD10561 trichogen cell, with Scer\GAL4pnr-MD237 Roe1GD10561
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Roe1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Roe1 Class Mutagen Stocks Known lesion Roe1GD10561 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10561} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
adenyl-nucleotide exchange factor activity inferred from electronic annotation with InterPro:IPR000740 (FlyBase Curators et al., 2004-) chaperone binding inferred from electronic annotation with InterPro:IPR000740 (FlyBase Curators et al., 2004-) protein homodimerization activity inferred from electronic annotation with InterPro:IPR000740 (FlyBase Curators et al., 2004-) unfolded protein binding inferred from sequence or structural similarity with Saccharomyces YGE1 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q8TAA5 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
protein folding inferred from sequence or structural similarity with UniProtKB:Q8TAA5 (Sardiello et al., 2003.6.11) non-traceable author statement (Palter, 1995.8.25) protein targeting to mitochondrion inferred from sequence or structural similarity with UniProtKB:Q8TAA5 (Sardiello et al., 2003.6.11) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from sequence or structural similarity with UniProtKB:Q8TAA5 (Sardiello et al., 2003.6.11) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) mitochondrion inferred from sequence or structural similarity with Saccharomyces YGE1 (FlyBase, 1992-) non-traceable author statement (Palter, 1995.8.25)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Roe1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62264 DroID - A comprehensive database of gene and protein interactions. • FBgn0014877 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36508
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13703 Dere\GG20391 Dgri\GH23157 Dmoj\GI18336 Dper\GL17413 Dpse\GA19397 Dsec\GM21478 Dsim\GD10974 Dvir\GJ19762 Dwil\GK15968 Dyak\GE12552
Curated drosophilid orthologs	Dpse\GA19397
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004438-PA Aedes aegypti (mosquito) AGAP011150-PA Anopheles gambiae (mosquito) XP_624159.1 Apis mellifera (honey bee) XP_001949679.1 Acyrthosiphon pisum (pea aphid) At4g26780.1 Arabidopsis thaliana (wall cress) 24663 Batrachochytrium dendrobatidis (chytrid fungus) 124277 Branchiostoma floridae (lancelet) XP_001892279.1 Brugia malayi (roundworm nematode) BGIBMGA009618-PA Bombyx mori (silk worm) ENSBTAP00000013431 Bos taurus (bovine) CAL0002414 Candida albicans (a form of yeast) CN23550 Caenorhabditis brenneri (small nematode) CBP16731 Caenorhabditis briggsae (nematode) CE03057 Caenorhabditis elegans (worm) ENSCAFP00000021192 Canis familiaris (dog) CAGL0J03850g Candida glabrata (haploid yeast) Chro.50021 Cryptosporidium hominis (obligate parasite) ENSCINP00000024337 Ciona intestinalis (sea squirt) JA02161 Caenorhabditis japonica (nematode) CML088C Cyanidioschyzon merolae (red alga) cn11132 Cryptococcus neoformans (yeast-like fungus) cgd5_3510 Cryptosporidium parvum (protozoan parasite) CPIJ008191 Culex pipens (mosquito) ENSCPOP00000011387 Cavia porcellus (guinea pig) 107685 Chlamidomonas reinhardtii (green alga) RP16896 Caenorhabditis remanei (nematode) ENSCSAVP00000008607 Ciona savignyi (sedentary tunicate) 165833 Capitella spl (polychaete worm) DDB0216255 Dictyostelium discoideum (amoeba) DEHA2C16830g Debaryomyces Hansenii (yeast) 305539 Daphnia pulex (daphnia) ENSDARP00000026495 Danio rerio (zebra fish) ENSECAP00000007642 Equus caballus (horse) NP_417104.1 Escherichia coli K12 (bacteria) ENSGACP00000001239 Gymnopilus aculeatus (mushroom) ENSGALP00000025020 Gallus gallus (chicken) 160398 Hypsipyla robusta (cedar shoot borer) ENSP00000264954 Homo sapiens (human) ISCW005818-PA Ixodes scapularis (deer tick) KLLA0D07326g Kluyveromyces lactis (yeast) 114637 Lottia gigantea (owl limpet) LmjF30.0730 Leishmania major (virus) 28513 Monocosta brevicollis (choanoflagellate) ENSMODP00000000081 Monodelphis domestica (gray opossum) ENSMODP00000003595 Monodelphis domestica (gray opossum) ENSMMUP00000022370 Macaca mulatta (rhesus monkey) ENSMUSP00000031099 Mus musculus (house mouse) 179966 Nematostella vectensis (starlet anemone) XP_001608280.1 Nasonia vitripennis (wasp) ENSOANP00000022896 Ornithorynchus anatinus (platypus) ENSORLP00000013386 Oryzias latipes (japanese killifish) LOC_Os08g25090.1 Oryza sativa (asian rice) 15411 Ostreococcus tauri (green alga) PF11_0258 Plasmodium falciparum (protozoal parasite) PHUM007732-PA Pediculus humanus (human body louse) PP04389 Pristionchus pacificus (nematode) 110204 Physcomitrella patens (moss) ENSPPYP00000016282 Pongo pygmaeus (orangutan) 71670 Phytophthora ramorum (sudden oak death pathogen) 108704 Phytophthora sojae (root rot pathogen) 251756 Populus trichocarpa (black cottonwood) ENSPTRP00000027375 Pan troglodytes (chimpanzee) PVX_091850 Plasmodium vivax (protozoal parasite) ENSRNOP00000008930 Rattus norvegicus (norway rat) 149319 Sorghum bicolor (sorghum) YOR232W Saccharomyces cerevisiae (budding yeast) Smp_062790 Schistosoma mansoni (trematode parasite) SPBC3B9.19 Schizosaccharomyces pombe (fission yeast) XP_001179550.1 Strongylocentrotus purpuratus (purple sea urchin) 21754 Trichoplax adhaerens (metazoa) TA06555 Theileria annulata (apicomplexan parasite) XP_967697.1 Tribolium castaneum (red flour beetle) Tc00.1047053507929.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509045.20 Trypanosoma cruzi (parasitic trypanosome) TP01_0947 Theileria parva (parasitic protozoan) 33653 Thalassiosira pseudonana (marine diatom) ENSTRUP00000023448 Takifugu rubripes (pufferfish Takifugu) 3836.m02092 Tetrahymena thermophila (ciliate protozoa) 90210.m00251 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049520 Xenopus tropicalis (frog) YALI0C18513g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10477 LH21107 ISCW005818 FBgn0230285 FBgn0224994 FBgn0217970 FBgn0213627 FBgn0206904 FBgn0182734 FBgn0176358 JGI_V11_305539 FBgn0079394 FBgn0155016 FBgn0141075 FBgn0130614 FBgn0112581 FBgn0090730 CPIJ008191 BGIBMGA009618 ACYPI010003 GB12067 AGAP012770 AGAP011150 AAEL004438 PB25889 PHUM227530 GLEAN_05006
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v34151 w1118; P{GD10561}v34151
Genomic Clones ( 2 )
	BACR14P04 BACR36J03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 166 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM03203 RE56495
Other clones	FI04716
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05837 AT07042 AT09263 AT09901 AT19534 AT31684 GM10477 RE10520 RE32605 RE37033 RE74991 RH08676 RH13442
Other clones	328 14594 42253 44934 64351 74428 108762 194862 bs53f03 bs57b09 bs62d04 bs68d06 bs77c01 CK01.146A.E12 Dmel_dig_009083_0680_0977 Dmel_dig_013444_0712_3526 EK107121 EK117017 EK173132 EK235217 FGC016B02 FGC018G11 FGC033E02 FGH102D02 FGH108B10 FGM301C07 FGM321D05 IP16886 IP16986 IP17186 RP003031454 RP003035961 RP003049286 RP003053568 RP003057768 RP003068759 RP003072769 RP003084444 RP003086788 RP003097263 RP003100888 RP003113669 RP003113865 RP003129142 RP003133021 RP003133520 RP003134422 RP003134966 RP003139127 RP003142304 RP003157612 RP003159061 RP003159670 RP003159973 RP003161512 RP003166269 RP003171803 RP003185139 RP003199593 RP003200427 RP003201603 RP003205527 RP003206015 RP003209841 RP003210485 RP003215069 RP003222254 RP003223670 RP003225158 RP003226899 RP003227761 RP003230575 RP003241615 RP003243858 RP003244063 RP003260868 RP003265787 RP003279376 RP003279398 RP003285140 RP003285425 RP003297277 RP003298326 RP003315501 RP003317618 RP003321949 RP003333852 RP003340756 RP003342546 RP003343502 RP003344674 RP003349406 RP003373606 RP003378758 RP003380251 RP003389122 RP003390976 RP003394384 RP003398368 RP003403014 RP003411338 RP003429211 RP003439909 RP003451211 RP003456393 RP003458332 RP003459733 RP003461893 RP003472779 RP003480076 RP003480957 RP003492114 RP003499334 RP003502333 RP003503296 RP003508683 RP003521218 RP003530468 RP003534408 RP003541335 RP003546700 RP003553917 RP003554336 RP003557114 RP003559851 RP003561183 RP003563814 RP003564850 RP003572608 RP003581152 RP003586807 RP003587834 RP003594624 RP003603385 RP003612512 RP003613348 RP003614179 RP003615235 RP003619800 RP003639820 RP003644629 RP003646564 RP003650920 RP003651054 RP003652831 RP003656683 RP003657732 RP003661327 RP003664457 RP003671931
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014877 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36508
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Roe1 BcDNA:GM03203 (BDGP Project Members, 2000-)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137042 RefSeq (Proteins) • NP_610886 DDBJ / EMBL / GenBank • AAA79044 AAF58354 AAM11242 AY094889 BI370100 U34903 Entrez Gene - A searchable database of RefSeq genes. • 36508 UniProtKB/Swiss-Prot • P48604 UniProtKB/TrEMBL • Q95SD0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GrpE nucleotide exchange factor (IPR000740) GrpE nucleotide exchange factor, head (IPR009012) GrpE nucleotide exchange factor, coiled-coil (IPR013805) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06155
Linkouts
	BioGRID - A database of protein and genetic interactions • 62264 DroID - A comprehensive database of gene and protein interactions. • FBgn0014877 DRSC - Results from RNAi screens. • FBgn0014877 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014877 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6155-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014877 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36508 InParanoid A subset of ortholog calls from InParanoid. • AAEL004438-PA Aedes aegypti (mosquito) AGAP011150-PA Anopheles gambiae (mosquito) XP_624159.1 Apis mellifera (honey bee) XP_001949679.1 Acyrthosiphon pisum (pea aphid) At4g26780.1 Arabidopsis thaliana (wall cress) 24663 Batrachochytrium dendrobatidis (chytrid fungus) 124277 Branchiostoma floridae (lancelet) XP_001892279.1 Brugia malayi (roundworm nematode) BGIBMGA009618-PA Bombyx mori (silk worm) ENSBTAP00000013431 Bos taurus (bovine) CAL0002414 Candida albicans (a form of yeast) CN23550 Caenorhabditis brenneri (small nematode) CBP16731 Caenorhabditis briggsae (nematode) CE03057 Caenorhabditis elegans (worm) ENSCAFP00000021192 Canis familiaris (dog) CAGL0J03850g Candida glabrata (haploid yeast) Chro.50021 Cryptosporidium hominis (obligate parasite) ENSCINP00000024337 Ciona intestinalis (sea squirt) JA02161 Caenorhabditis japonica (nematode) CML088C Cyanidioschyzon merolae (red alga) cn11132 Cryptococcus neoformans (yeast-like fungus) cgd5_3510 Cryptosporidium parvum (protozoan parasite) CPIJ008191 Culex pipens (mosquito) ENSCPOP00000011387 Cavia porcellus (guinea pig) 107685 Chlamidomonas reinhardtii (green alga) RP16896 Caenorhabditis remanei (nematode) ENSCSAVP00000008607 Ciona savignyi (sedentary tunicate) 165833 Capitella spl (polychaete worm) DDB0216255 Dictyostelium discoideum (amoeba) DEHA2C16830g Debaryomyces Hansenii (yeast) 305539 Daphnia pulex (daphnia) ENSDARP00000026495 Danio rerio (zebra fish) ENSECAP00000007642 Equus caballus (horse) NP_417104.1 Escherichia coli K12 (bacteria) ENSGACP00000001239 Gymnopilus aculeatus (mushroom) ENSGALP00000025020 Gallus gallus (chicken) 160398 Hypsipyla robusta (cedar shoot borer) ENSP00000264954 Homo sapiens (human) ISCW005818-PA Ixodes scapularis (deer tick) KLLA0D07326g Kluyveromyces lactis (yeast) 114637 Lottia gigantea (owl limpet) LmjF30.0730 Leishmania major (virus) 28513 Monocosta brevicollis (choanoflagellate) ENSMODP00000000081 Monodelphis domestica (gray opossum) ENSMODP00000003595 Monodelphis domestica (gray opossum) ENSMMUP00000022370 Macaca mulatta (rhesus monkey) ENSMUSP00000031099 Mus musculus (house mouse) 179966 Nematostella vectensis (starlet anemone) XP_001608280.1 Nasonia vitripennis (wasp) ENSOANP00000022896 Ornithorynchus anatinus (platypus) ENSORLP00000013386 Oryzias latipes (japanese killifish) LOC_Os08g25090.1 Oryza sativa (asian rice) 15411 Ostreococcus tauri (green alga) PF11_0258 Plasmodium falciparum (protozoal parasite) PHUM007732-PA Pediculus humanus (human body louse) PP04389 Pristionchus pacificus (nematode) 110204 Physcomitrella patens (moss) ENSPPYP00000016282 Pongo pygmaeus (orangutan) 71670 Phytophthora ramorum (sudden oak death pathogen) 108704 Phytophthora sojae (root rot pathogen) 251756 Populus trichocarpa (black cottonwood) ENSPTRP00000027375 Pan troglodytes (chimpanzee) PVX_091850 Plasmodium vivax (protozoal parasite) ENSRNOP00000008930 Rattus norvegicus (norway rat) 149319 Sorghum bicolor (sorghum) YOR232W Saccharomyces cerevisiae (budding yeast) Smp_062790 Schistosoma mansoni (trematode parasite) SPBC3B9.19 Schizosaccharomyces pombe (fission yeast) XP_001179550.1 Strongylocentrotus purpuratus (purple sea urchin) 21754 Trichoplax adhaerens (metazoa) TA06555 Theileria annulata (apicomplexan parasite) XP_967697.1 Tribolium castaneum (red flour beetle) Tc00.1047053507929.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509045.20 Trypanosoma cruzi (parasitic trypanosome) TP01_0947 Theileria parva (parasitic protozoan) 33653 Thalassiosira pseudonana (marine diatom) ENSTRUP00000023448 Takifugu rubripes (pufferfish Takifugu) 3836.m02092 Tetrahymena thermophila (ciliate protozoa) 90210.m00251 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049520 Xenopus tropicalis (frog) YALI0C18513g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36508 modMine - Data generated by the modENCODE project. • FBgn0014877 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10477 LH21107 ISCW005818 FBgn0230285 FBgn0224994 FBgn0217970 FBgn0213627 FBgn0206904 FBgn0182734 FBgn0176358 JGI_V11_305539 FBgn0079394 FBgn0155016 FBgn0141075 FBgn0130614 FBgn0112581 FBgn0090730 CPIJ008191 BGIBMGA009618 ACYPI010003 GB12067 AGAP012770 AGAP011150 AAEL004438 PB25889 PHUM227530 GLEAN_05006
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	BcDNA:GM03203   CG6155 (Haussmann et al., 2008, Cammarato et al., 2011) cg6155 (Xu et al., 2003) DROE1 (Palter, 1995.8.25) droe1 (Mehta et al., 1995) Droe1   Roe1
Name Synonym	Roe1 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0064950
References ( 19 )
Research paper	Haussmann et al., 2008, Genome Biol. 9(4): R73 Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. [FBrf0209726] Xu et al., 2003, Hum. Molec. Genet. 12(2): 169--175 Human BOULE gene rescues meiotic defects in infertile flies. [FBrf0155839]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Lee and Palter, 1997, Gething, 1997: 141--142 Drosophila melanogaster Droe1p. [FBrf0105150]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903]
Abstract	Mehta et al., 1995, Molec. Biol. Cell 6(Suppl.): 67a Purification and characterization of DROE1, a Drosophila homolog of bacterial GRPE. [FBrf0085561]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Palter, 1995.8.25, GenBank/EMBL/DDBJ: U34903 Drosophila melanogaster grpE homolog (DROE1) mRNA, nuclear gene encoding mitochondrial protein, complete cds. [FBrf0118738]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Protein sequence record	Swiss-Prot Project Members, 1996.2.1, UniProtKB: P48604 GRPE PROTEIN HOMOLOG PRECURSOR. [FBrf0124083]
Curated genome annotation	Beasley, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126653]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]