General Information Symbol Dmel\ SetSpecies D. melanogaster Name Set Annotation symbol CG4299 Feature type protein_coding_gene FlyBase ID FBgn0014879 Gene Model Status Current Stock availability 3 publicly
available Also Known As dSET Genomic Location Chromosome (arm) 3R Recombination map Cytogenetic map 88E8-88E8 Sequence location 3R:11,089,274..11,090,975 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
Set is referred to in FlyBase by the symbol
Dmel\Set (CG4299, FBgn0014879). It is a protein_coding_gene from
Drosophila melanogaster . It is reported to have
molecular function : cyclin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the
biological process : nucleosome assembly.
6 alleles are reported . No phenotypic data is available. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: Nucleosome assembly protein (NAP). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637578_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Set. Gene sequence location is
3R:11089274..11090975 .
User Contributed Data
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It currently only tracks new links between this FlyBase report and other
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.47
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
1579.9
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
859.5
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
1084.2
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(1579.9)
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
(859.5)
Larval Trachea
(662.1)
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
(1084.2)
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
(1579.9)
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
859.5
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
(1084.2)
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
1579.9
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
859.5
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
1084.2
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
1579.9
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
859.5
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
1084.2
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(1579.9)
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
(859.5)
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
(1084.2)
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
1579.9
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
859.5
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
1084.2
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
1579.9
Larval Midgut
219.7
Larval Hindgut
311.2
Larval Malpighian Tubules
265.8
Larval Fat Body
235.9
Larval Salivary Gland
859.5
Larval Trachea
662.1
Larval Carcass
422.075
Adult Head
172.9
Adult Eye
265.05
Adult Brain
255
Adult Thoracic-Abdominal Ganglion
252.9
Adult Crop
253.9
Adult Midgut
230.6
Adult Hindgut
223.7
Adult Malpighian Tubules
210.3
Adult Fat Body
192
Adult Salivary Gland
169.6
Adult Heart
196
Adult VirginFemale Spermatheca
120
Adult InseminatedFemale Spermatheca
149.7
Adult Ovary
1084.2
Adult Testis
201.7
Adult Male Accessory Gland
392.7
Adult Carcass
135
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
172.9
NA
Eye
265.05
NA
Brain
255
1579.9
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
252.9
NA
Crop
253.9
219.7
Midgut
230.6
311.2
Hindgut
223.7
265.8
Malpighian Tubules
210.3
235.9
Fat Body
192
859.5
Salivary Gland
169.6
NA
Heart
196
662.1
Trachea
NA
NA
VirginFemale Spermatheca
120
NA
InseminatedFemale Spermatheca
149.7
NA
Ovary
1084.2
NA
Testis
201.7
NA
Male Accessory Gland
392.7
422.075
Carcass
135
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
177
central nervous system, larvae L3
480
central nervous system, pupae P8
117
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
43
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
54
head, mated 20-day male
64
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
39
digestive system, larvae L3 wandering
57
digestive system, 1-day adult
35
digestive system, 4-day adult
69
digestive system, 20-day adult
36
fat body, larvae L3 wandering
23
fat body, white prepupae
68
fat body, pupae P8
76
carcass, larvae L3 wandering
211
carcass, 1-day adult
29
carcass, 4-day adult
52
carcass, 20-day adult
30
ovary, virgin 4-day female
304
ovary, mated 4-day female
426
testis, mated 4-day male
62
accessory gland, mated 4-day male
49
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(177)
central nervous system, larvae L3
(480)
central nervous system, pupae P8
(117)
head, virgin 1-day female
(31)
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
(28)
head, mated 4-day female
(43)
head, mated 20-day female
19
head, mated 1-day male
(30)
head, mated 4-day male
(54)
head, mated 20-day male
(64)
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
(39)
digestive system, larvae L3 wandering
(57)
digestive system, 1-day adult
(35)
digestive system, 4-day adult
(69)
digestive system, 20-day adult
(36)
fat body, larvae L3 wandering
23
fat body, white prepupae
(68)
fat body, pupae P8
(76)
carcass, larvae L3 wandering
(211)
carcass, 1-day adult
(29)
carcass, 4-day adult
(52)
carcass, 20-day adult
(30)
ovary, virgin 4-day female
(304)
ovary, mated 4-day female
(426)
testis, mated 4-day male
(62)
accessory gland, mated 4-day male
(49)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(177)
central nervous system, larvae L3
(480)
central nervous system, pupae P8
(117)
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
43
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
54
head, mated 20-day male
64
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
39
digestive system, larvae L3 wandering
57
digestive system, 1-day adult
35
digestive system, 4-day adult
69
digestive system, 20-day adult
36
fat body, larvae L3 wandering
23
fat body, white prepupae
68
fat body, pupae P8
76
carcass, larvae L3 wandering
(211)
carcass, 1-day adult
29
carcass, 4-day adult
52
carcass, 20-day adult
30
ovary, virgin 4-day female
(304)
ovary, mated 4-day female
(426)
testis, mated 4-day male
62
accessory gland, mated 4-day male
49
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
177
central nervous system, larvae L3
480
central nervous system, pupae P8
117
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
43
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
54
head, mated 20-day male
64
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
39
digestive system, larvae L3 wandering
57
digestive system, 1-day adult
35
digestive system, 4-day adult
69
digestive system, 20-day adult
36
fat body, larvae L3 wandering
23
fat body, white prepupae
68
fat body, pupae P8
76
carcass, larvae L3 wandering
211
carcass, 1-day adult
29
carcass, 4-day adult
52
carcass, 20-day adult
30
ovary, virgin 4-day female
304
ovary, mated 4-day female
426
testis, mated 4-day male
62
accessory gland, mated 4-day male
49
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
177
central nervous system, larvae L3
480
central nervous system, pupae P8
117
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
43
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
54
head, mated 20-day male
64
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
39
digestive system, larvae L3 wandering
57
digestive system, 1-day adult
35
digestive system, 4-day adult
69
digestive system, 20-day adult
36
fat body, larvae L3 wandering
23
fat body, white prepupae
68
fat body, pupae P8
76
carcass, larvae L3 wandering
211
carcass, 1-day adult
29
carcass, 4-day adult
52
carcass, 20-day adult
30
ovary, virgin 4-day female
304
ovary, mated 4-day female
426
testis, mated 4-day male
62
accessory gland, mated 4-day male
49
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(177)
central nervous system, larvae L3
(480)
central nervous system, pupae P8
(117)
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
(43)
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
(54)
head, mated 20-day male
(64)
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
(39)
digestive system, larvae L3 wandering
(57)
digestive system, 1-day adult
(35)
digestive system, 4-day adult
(69)
digestive system, 20-day adult
(36)
fat body, larvae L3 wandering
23
fat body, white prepupae
(68)
fat body, pupae P8
(76)
carcass, larvae L3 wandering
(211)
carcass, 1-day adult
29
carcass, 4-day adult
(52)
carcass, 20-day adult
30
ovary, virgin 4-day female
(304)
ovary, mated 4-day female
(426)
testis, mated 4-day male
(62)
accessory gland, mated 4-day male
(49)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(177)
central nervous system, larvae L3
(480)
central nervous system, pupae P8
117
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
43
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
54
head, mated 20-day male
64
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
39
digestive system, larvae L3 wandering
57
digestive system, 1-day adult
35
digestive system, 4-day adult
69
digestive system, 20-day adult
36
fat body, larvae L3 wandering
23
fat body, white prepupae
68
fat body, pupae P8
76
carcass, larvae L3 wandering
(211)
carcass, 1-day adult
29
carcass, 4-day adult
52
carcass, 20-day adult
30
ovary, virgin 4-day female
(304)
ovary, mated 4-day female
(426)
testis, mated 4-day male
62
accessory gland, mated 4-day male
49
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
177
central nervous system, larvae L3
480
central nervous system, pupae P8
117
head, virgin 1-day female
31
head, virgin 4-day female
23
head, virgin 20-day female
19
head, mated 1-day female
28
head, mated 4-day female
43
head, mated 20-day female
19
head, mated 1-day male
30
head, mated 4-day male
54
head, mated 20-day male
64
salivary gland, larvae L3 wandering
24
salivary gland, white prepupae
39
digestive system, larvae L3 wandering
57
digestive system, 1-day adult
35
digestive system, 4-day adult
69
digestive system, 20-day adult
36
fat body, larvae L3 wandering
23
fat body, white prepupae
68
fat body, pupae P8
76
carcass, larvae L3 wandering
211
carcass, 1-day adult
29
carcass, 4-day adult
52
carcass, 20-day adult
30
ovary, virgin 4-day female
304
ovary, mated 4-day female
426
testis, mated 4-day male
62
accessory gland, mated 4-day male
49
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
195
embryo 02-04hr
369
embryo 04-06hr
492
embryo 06-08hr
341
embryo 08-10hr
256
embryo 10-12hr
160
embryo 12-14hr
130
embryo 14-16hr
76
embryo 16-18hr
63
embryo 18-20hr
30
embryo 20-22hr
74
embryo 22-24hr
74
larva L1
35
larva L2
53
larva L3 12hr old
43
larva L3 puffstage 1-2
55
larva L3 puffstage 3-6
73
larva L3 puffstage 7-9
103
white prepupae new
96
white prepupae 12hr
102
white prepupae 24hr
120
pupae 2d postWPP
57
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
66
adult female 05day
126
adult female 30day
122
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(195)
embryo 02-04hr
(369)
embryo 04-06hr
(492)
embryo 06-08hr
(341)
embryo 08-10hr
(256)
embryo 10-12hr
(160)
embryo 12-14hr
(130)
embryo 14-16hr
(76)
embryo 16-18hr
(63)
embryo 18-20hr
(30)
embryo 20-22hr
(74)
embryo 22-24hr
(74)
larva L1
(35)
larva L2
(53)
larva L3 12hr old
(43)
larva L3 puffstage 1-2
(55)
larva L3 puffstage 3-6
(73)
larva L3 puffstage 7-9
(103)
white prepupae new
(96)
white prepupae 12hr
(102)
white prepupae 24hr
(120)
pupae 2d postWPP
(57)
pupae 3d postWPP
(27)
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
(66)
adult female 05day
(126)
adult female 30day
(122)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(195)
embryo 02-04hr
(369)
embryo 04-06hr
(492)
embryo 06-08hr
(341)
embryo 08-10hr
(256)
embryo 10-12hr
(160)
embryo 12-14hr
(130)
embryo 14-16hr
76
embryo 16-18hr
63
embryo 18-20hr
30
embryo 20-22hr
74
embryo 22-24hr
74
larva L1
35
larva L2
53
larva L3 12hr old
43
larva L3 puffstage 1-2
55
larva L3 puffstage 3-6
73
larva L3 puffstage 7-9
103
white prepupae new
96
white prepupae 12hr
102
white prepupae 24hr
(120)
pupae 2d postWPP
57
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
66
adult female 05day
(126)
adult female 30day
(122)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
195
embryo 02-04hr
369
embryo 04-06hr
492
embryo 06-08hr
341
embryo 08-10hr
256
embryo 10-12hr
160
embryo 12-14hr
130
embryo 14-16hr
76
embryo 16-18hr
63
embryo 18-20hr
30
embryo 20-22hr
74
embryo 22-24hr
74
larva L1
35
larva L2
53
larva L3 12hr old
43
larva L3 puffstage 1-2
55
larva L3 puffstage 3-6
73
larva L3 puffstage 7-9
103
white prepupae new
96
white prepupae 12hr
102
white prepupae 24hr
120
pupae 2d postWPP
57
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
66
adult female 05day
126
adult female 30day
122
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
195
embryo 02-04hr
369
embryo 04-06hr
492
embryo 06-08hr
341
embryo 08-10hr
256
embryo 10-12hr
160
embryo 12-14hr
130
embryo 14-16hr
76
embryo 16-18hr
63
embryo 18-20hr
30
embryo 20-22hr
74
embryo 22-24hr
74
larva L1
35
larva L2
53
larva L3 12hr old
43
larva L3 puffstage 1-2
55
larva L3 puffstage 3-6
73
larva L3 puffstage 7-9
103
white prepupae new
96
white prepupae 12hr
102
white prepupae 24hr
120
pupae 2d postWPP
57
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
66
adult female 05day
126
adult female 30day
122
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(195)
embryo 02-04hr
(369)
embryo 04-06hr
(492)
embryo 06-08hr
(341)
embryo 08-10hr
(256)
embryo 10-12hr
(160)
embryo 12-14hr
(130)
embryo 14-16hr
(76)
embryo 16-18hr
(63)
embryo 18-20hr
30
embryo 20-22hr
(74)
embryo 22-24hr
(74)
larva L1
(35)
larva L2
(53)
larva L3 12hr old
(43)
larva L3 puffstage 1-2
(55)
larva L3 puffstage 3-6
(73)
larva L3 puffstage 7-9
(103)
white prepupae new
(96)
white prepupae 12hr
(102)
white prepupae 24hr
(120)
pupae 2d postWPP
(57)
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
(66)
adult female 05day
(126)
adult female 30day
(122)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(195)
embryo 02-04hr
(369)
embryo 04-06hr
(492)
embryo 06-08hr
(341)
embryo 08-10hr
(256)
embryo 10-12hr
(160)
embryo 12-14hr
130
embryo 14-16hr
76
embryo 16-18hr
63
embryo 18-20hr
30
embryo 20-22hr
74
embryo 22-24hr
74
larva L1
35
larva L2
53
larva L3 12hr old
43
larva L3 puffstage 1-2
55
larva L3 puffstage 3-6
73
larva L3 puffstage 7-9
103
white prepupae new
96
white prepupae 12hr
102
white prepupae 24hr
120
pupae 2d postWPP
57
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
66
adult female 05day
126
adult female 30day
122
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
195
embryo 02-04hr
369
embryo 04-06hr
492
embryo 06-08hr
341
embryo 08-10hr
256
embryo 10-12hr
160
embryo 12-14hr
130
embryo 14-16hr
76
embryo 16-18hr
63
embryo 18-20hr
30
embryo 20-22hr
74
embryo 22-24hr
74
larva L1
35
larva L2
53
larva L3 12hr old
43
larva L3 puffstage 1-2
55
larva L3 puffstage 3-6
73
larva L3 puffstage 7-9
103
white prepupae new
96
white prepupae 12hr
102
white prepupae 24hr
120
pupae 2d postWPP
57
pupae 3d postWPP
27
pupae 4d postWPP
20
adult male 01day
18
adult male 05day
20
adult male 30day
19
adult female 01day
66
adult female 05day
126
adult female 30day
122
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
259
Schneider line 2 Sg4
185
embryonic 1182-4H
224
embryonic GM2
128
embryonic Kc167
158
embryonic S1
174
embryonic S3
253
leg disc CME L1
338
wing disc CME-W2
201
wing disc ML-DmD8
223
wing disc ML-DmD9
283
wing disc ML-DmD16-c3
285
wing disc ML-DmD21
301
wing disc ML-DmD32
205
haltere disc ML-DmD17-c3
169
eye-antennal disc ML-DmD11
181
antennal disc ML-DmD20-c5
217
mixed discs ML-DmD4-c1
248
CNS ML-DmBG1-c1
278
CNS ML-DmBG2-c2
153
tumorous blood cells mbn2
139
ovary fGS/OSS
447
ovary OSC
437
ovary OSS
513
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(259)
Schneider line 2 Sg4
(185)
embryonic 1182-4H
(224)
embryonic GM2
(128)
embryonic Kc167
(158)
embryonic S1
(174)
embryonic S3
(253)
leg disc CME L1
(338)
wing disc CME-W2
(201)
wing disc ML-DmD8
(223)
wing disc ML-DmD9
(283)
wing disc ML-DmD16-c3
(285)
wing disc ML-DmD21
(301)
wing disc ML-DmD32
(205)
haltere disc ML-DmD17-c3
(169)
eye-antennal disc ML-DmD11
(181)
antennal disc ML-DmD20-c5
(217)
mixed discs ML-DmD4-c1
(248)
CNS ML-DmBG1-c1
(278)
CNS ML-DmBG2-c2
(153)
tumorous blood cells mbn2
(139)
ovary fGS/OSS
(447)
ovary OSC
(437)
ovary OSS
(513)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(259)
Schneider line 2 Sg4
(185)
embryonic 1182-4H
(224)
embryonic GM2
(128)
embryonic Kc167
(158)
embryonic S1
(174)
embryonic S3
(253)
leg disc CME L1
(338)
wing disc CME-W2
(201)
wing disc ML-DmD8
(223)
wing disc ML-DmD9
(283)
wing disc ML-DmD16-c3
(285)
wing disc ML-DmD21
(301)
wing disc ML-DmD32
(205)
haltere disc ML-DmD17-c3
(169)
eye-antennal disc ML-DmD11
(181)
antennal disc ML-DmD20-c5
(217)
mixed discs ML-DmD4-c1
(248)
CNS ML-DmBG1-c1
(278)
CNS ML-DmBG2-c2
(153)
tumorous blood cells mbn2
(139)
ovary fGS/OSS
(447)
ovary OSC
(437)
ovary OSS
(513)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
259
Schneider line 2 Sg4
185
embryonic 1182-4H
224
embryonic GM2
128
embryonic Kc167
158
embryonic S1
174
embryonic S3
253
leg disc CME L1
338
wing disc CME-W2
201
wing disc ML-DmD8
223
wing disc ML-DmD9
283
wing disc ML-DmD16-c3
285
wing disc ML-DmD21
301
wing disc ML-DmD32
205
haltere disc ML-DmD17-c3
169
eye-antennal disc ML-DmD11
181
antennal disc ML-DmD20-c5
217
mixed discs ML-DmD4-c1
248
CNS ML-DmBG1-c1
278
CNS ML-DmBG2-c2
153
tumorous blood cells mbn2
139
ovary fGS/OSS
447
ovary OSC
437
ovary OSS
513
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
259
Schneider line 2 Sg4
185
embryonic 1182-4H
224
embryonic GM2
128
embryonic Kc167
158
embryonic S1
174
embryonic S3
253
leg disc CME L1
338
wing disc CME-W2
201
wing disc ML-DmD8
223
wing disc ML-DmD9
283
wing disc ML-DmD16-c3
285
wing disc ML-DmD21
301
wing disc ML-DmD32
205
haltere disc ML-DmD17-c3
169
eye-antennal disc ML-DmD11
181
antennal disc ML-DmD20-c5
217
mixed discs ML-DmD4-c1
248
CNS ML-DmBG1-c1
278
CNS ML-DmBG2-c2
153
tumorous blood cells mbn2
139
ovary fGS/OSS
447
ovary OSC
437
ovary OSS
513
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(259)
Schneider line 2 Sg4
(185)
embryonic 1182-4H
(224)
embryonic GM2
(128)
embryonic Kc167
(158)
embryonic S1
(174)
embryonic S3
(253)
leg disc CME L1
(338)
wing disc CME-W2
(201)
wing disc ML-DmD8
(223)
wing disc ML-DmD9
(283)
wing disc ML-DmD16-c3
(285)
wing disc ML-DmD21
(301)
wing disc ML-DmD32
(205)
haltere disc ML-DmD17-c3
(169)
eye-antennal disc ML-DmD11
(181)
antennal disc ML-DmD20-c5
(217)
mixed discs ML-DmD4-c1
(248)
CNS ML-DmBG1-c1
(278)
CNS ML-DmBG2-c2
(153)
tumorous blood cells mbn2
(139)
ovary fGS/OSS
(447)
ovary OSC
(437)
ovary OSS
(513)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(259)
Schneider line 2 Sg4
(185)
embryonic 1182-4H
(224)
embryonic GM2
128
embryonic Kc167
(158)
embryonic S1
(174)
embryonic S3
(253)
leg disc CME L1
(338)
wing disc CME-W2
(201)
wing disc ML-DmD8
(223)
wing disc ML-DmD9
(283)
wing disc ML-DmD16-c3
(285)
wing disc ML-DmD21
(301)
wing disc ML-DmD32
(205)
haltere disc ML-DmD17-c3
(169)
eye-antennal disc ML-DmD11
(181)
antennal disc ML-DmD20-c5
(217)
mixed discs ML-DmD4-c1
(248)
CNS ML-DmBG1-c1
(278)
CNS ML-DmBG2-c2
(153)
tumorous blood cells mbn2
139
ovary fGS/OSS
(447)
ovary OSC
(437)
ovary OSS
(513)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
259
Schneider line 2 Sg4
185
embryonic 1182-4H
224
embryonic GM2
128
embryonic Kc167
158
embryonic S1
174
embryonic S3
253
leg disc CME L1
338
wing disc CME-W2
201
wing disc ML-DmD8
223
wing disc ML-DmD9
283
wing disc ML-DmD16-c3
285
wing disc ML-DmD21
301
wing disc ML-DmD32
205
haltere disc ML-DmD17-c3
169
eye-antennal disc ML-DmD11
181
antennal disc ML-DmD20-c5
217
mixed discs ML-DmD4-c1
248
CNS ML-DmBG1-c1
278
CNS ML-DmBG2-c2
153
tumorous blood cells mbn2
139
ovary fGS/OSS
447
ovary OSC
437
ovary OSS
513
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
224
cold shock, 4-day adult
140
heat shock, 4-day adult
132
Cadmium 50 mM 6 hrs, larvae L3
71
Cadmium 50 mM 12 hrs, larvae L3
122
Cadmium 50 mM 48 hrs, 4-day adult
125
Cadmium 100 mM 48 hrs, 4-day adult
255
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
266
Zinc 5 mM 12 hrs, larvae L3
160
Zinc 4.5 mM 48 hrs, 4-day adult
140
Ethanol 2.5% 3 hrs, larvae L3
179
Ethanol 5% 3 hrs, larvae L3
65
Ethanol 10% 3 hrs, larvae L3
74
Caffeine 1.5 mg/ml 4 hrs, larvae L3
47
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
232
Caffeine 25 mg/ml 48 hrs, 4-day adult
196
Paraquat 5 mM 48 hrs, 4-day adult
199
Paraquat 10 mM 48 hrs, 4-day adult
116
Rotenone 2 μg 12 hrs, larvae L3
73
Rotenone 8 μg 12 hrs, larvae L3
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(224)
cold shock, 4-day adult
(140)
heat shock, 4-day adult
(132)
Cadmium 50 mM 6 hrs, larvae L3
(71)
Cadmium 50 mM 12 hrs, larvae L3
(122)
Cadmium 50 mM 48 hrs, 4-day adult
(125)
Cadmium 100 mM 48 hrs, 4-day adult
(255)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
(266)
Zinc 5 mM 12 hrs, larvae L3
(160)
Zinc 4.5 mM 48 hrs, 4-day adult
(140)
Ethanol 2.5% 3 hrs, larvae L3
(179)
Ethanol 5% 3 hrs, larvae L3
(65)
Ethanol 10% 3 hrs, larvae L3
(74)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(47)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(232)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(196)
Paraquat 5 mM 48 hrs, 4-day adult
(199)
Paraquat 10 mM 48 hrs, 4-day adult
(116)
Rotenone 2 μg 12 hrs, larvae L3
(73)
Rotenone 8 μg 12 hrs, larvae L3
(44)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
(224)
cold shock, 4-day adult
(140)
heat shock, 4-day adult
(132)
Cadmium 50 mM 6 hrs, larvae L3
71
Cadmium 50 mM 12 hrs, larvae L3
(122)
Cadmium 50 mM 48 hrs, 4-day adult
(125)
Cadmium 100 mM 48 hrs, 4-day adult
(255)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
(266)
Zinc 5 mM 12 hrs, larvae L3
(160)
Zinc 4.5 mM 48 hrs, 4-day adult
(140)
Ethanol 2.5% 3 hrs, larvae L3
(179)
Ethanol 5% 3 hrs, larvae L3
65
Ethanol 10% 3 hrs, larvae L3
74
Caffeine 1.5 mg/ml 4 hrs, larvae L3
47
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(232)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(196)
Paraquat 5 mM 48 hrs, 4-day adult
(199)
Paraquat 10 mM 48 hrs, 4-day adult
(116)
Rotenone 2 μg 12 hrs, larvae L3
73
Rotenone 8 μg 12 hrs, larvae L3
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
224
cold shock, 4-day adult
140
heat shock, 4-day adult
132
Cadmium 50 mM 6 hrs, larvae L3
71
Cadmium 50 mM 12 hrs, larvae L3
122
Cadmium 50 mM 48 hrs, 4-day adult
125
Cadmium 100 mM 48 hrs, 4-day adult
255
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
266
Zinc 5 mM 12 hrs, larvae L3
160
Zinc 4.5 mM 48 hrs, 4-day adult
140
Ethanol 2.5% 3 hrs, larvae L3
179
Ethanol 5% 3 hrs, larvae L3
65
Ethanol 10% 3 hrs, larvae L3
74
Caffeine 1.5 mg/ml 4 hrs, larvae L3
47
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
232
Caffeine 25 mg/ml 48 hrs, 4-day adult
196
Paraquat 5 mM 48 hrs, 4-day adult
199
Paraquat 10 mM 48 hrs, 4-day adult
116
Rotenone 2 μg 12 hrs, larvae L3
73
Rotenone 8 μg 12 hrs, larvae L3
44
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
224
cold shock, 4-day adult
140
heat shock, 4-day adult
132
Cadmium 50 mM 6 hrs, larvae L3
71
Cadmium 50 mM 12 hrs, larvae L3
122
Cadmium 50 mM 48 hrs, 4-day adult
125
Cadmium 100 mM 48 hrs, 4-day adult
255
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
266
Zinc 5 mM 12 hrs, larvae L3
160
Zinc 4.5 mM 48 hrs, 4-day adult
140
Ethanol 2.5% 3 hrs, larvae L3
179
Ethanol 5% 3 hrs, larvae L3
65
Ethanol 10% 3 hrs, larvae L3
74
Caffeine 1.5 mg/ml 4 hrs, larvae L3
47
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
232
Caffeine 25 mg/ml 48 hrs, 4-day adult
196
Paraquat 5 mM 48 hrs, 4-day adult
199
Paraquat 10 mM 48 hrs, 4-day adult
116
Rotenone 2 μg 12 hrs, larvae L3
73
Rotenone 8 μg 12 hrs, larvae L3
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(224)
cold shock, 4-day adult
(140)
heat shock, 4-day adult
(132)
Cadmium 50 mM 6 hrs, larvae L3
(71)
Cadmium 50 mM 12 hrs, larvae L3
(122)
Cadmium 50 mM 48 hrs, 4-day adult
(125)
Cadmium 100 mM 48 hrs, 4-day adult
(255)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
(266)
Zinc 5 mM 12 hrs, larvae L3
(160)
Zinc 4.5 mM 48 hrs, 4-day adult
(140)
Ethanol 2.5% 3 hrs, larvae L3
(179)
Ethanol 5% 3 hrs, larvae L3
(65)
Ethanol 10% 3 hrs, larvae L3
(74)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(47)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(232)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(196)
Paraquat 5 mM 48 hrs, 4-day adult
(199)
Paraquat 10 mM 48 hrs, 4-day adult
(116)
Rotenone 2 μg 12 hrs, larvae L3
(73)
Rotenone 8 μg 12 hrs, larvae L3
(44)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
(224)
cold shock, 4-day adult
140
heat shock, 4-day adult
132
Cadmium 50 mM 6 hrs, larvae L3
71
Cadmium 50 mM 12 hrs, larvae L3
122
Cadmium 50 mM 48 hrs, 4-day adult
125
Cadmium 100 mM 48 hrs, 4-day adult
(255)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
(266)
Zinc 5 mM 12 hrs, larvae L3
(160)
Zinc 4.5 mM 48 hrs, 4-day adult
140
Ethanol 2.5% 3 hrs, larvae L3
(179)
Ethanol 5% 3 hrs, larvae L3
65
Ethanol 10% 3 hrs, larvae L3
74
Caffeine 1.5 mg/ml 4 hrs, larvae L3
47
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(232)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(196)
Paraquat 5 mM 48 hrs, 4-day adult
(199)
Paraquat 10 mM 48 hrs, 4-day adult
116
Rotenone 2 μg 12 hrs, larvae L3
73
Rotenone 8 μg 12 hrs, larvae L3
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
224
cold shock, 4-day adult
140
heat shock, 4-day adult
132
Cadmium 50 mM 6 hrs, larvae L3
71
Cadmium 50 mM 12 hrs, larvae L3
122
Cadmium 50 mM 48 hrs, 4-day adult
125
Cadmium 100 mM 48 hrs, 4-day adult
255
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
266
Zinc 5 mM 12 hrs, larvae L3
160
Zinc 4.5 mM 48 hrs, 4-day adult
140
Ethanol 2.5% 3 hrs, larvae L3
179
Ethanol 5% 3 hrs, larvae L3
65
Ethanol 10% 3 hrs, larvae L3
74
Caffeine 1.5 mg/ml 4 hrs, larvae L3
47
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
232
Caffeine 25 mg/ml 48 hrs, 4-day adult
196
Paraquat 5 mM 48 hrs, 4-day adult
199
Paraquat 10 mM 48 hrs, 4-day adult
116
Rotenone 2 μg 12 hrs, larvae L3
73
Rotenone 8 μg 12 hrs, larvae L3
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 2 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 4 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions insertion of mobile activating element
Gene Ontology: Function, Process
& Cellular Component ( 3 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 3 terms ) Molecular Function non-traceable author statement
Biological Process Cellular Component inferred from sequence or structural similarity with
EMBL:AB015613 Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (41)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG61NV69 )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6FBJ2W )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6ZKHHD )
Apis mellifera
Western honey bee
Amel\GB50699
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011778
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH11558
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH11581
Atta cephalotes
Leafcutter ant
Acep\ACEP13163
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO17205
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL18929
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB21608
Solenopsis invicta
Red fire ant
Sinv\SINV17684
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6Q83DQ )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6JMMJ3 )
Caenorhabditis elegans
Nematode
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Rattus norvegicus
Norway rat
Rattus norvegicus
Norway rat
Rattus norvegicus
Norway rat
Human Orthologs (0)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 3 )Bloomington Harvard VDRC Genomic Clones ( 2 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 145 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Other Comments Isolated from an embryo cDNA library using PCR.
A
Set cDNA has been cloned and sequenced.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 6 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 29 )Generate a list of List References by type
Recent research papers ( 3 )
Kim et al., 2012, Nucleic Acids Res. 40(1): 75--87Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. [FBrf0217088] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011