FB2021_02, released April 13, 2021

Gene: Dmel\AhcyL2

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General Information
Symbol
Dmel\AhcyL2
Species
D. melanogaster
Name
Adenosylhomocysteinase like 2
Annotation Symbol
CG8956
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015011
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Adenosylhomocysteinase like 2 (AhcyL2) encodes a protein that, together with the product of AhcyL1, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and production of deoxyribonucleotides. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Ahcy89E, AHCY, pH200

Key Links
Genomic Location
Cytogenetic map
89E5-89E5
Sequence location
3R:16,978,439..16,982,158 [-]
Recombination map
3-59
RefSeq locus
NT_033777 REGION:16978439..16982158
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables adenosylhomocysteinase activity
inferred from electronic annotation with InterPro:IPR000043, InterPro:IPR020082
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in S-adenosylmethionine cycle
inferred from biological aspect of ancestor with PANTHER:PTN000602759
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000602759
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the adenosylhomocysteinase family. (P50245)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Adenosylhomocysteinase like 2 (AhcyL2) encodes a protein that, together with the product of AhcyL1, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and production of deoxyribonucleotides. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Might play a role in the regulation of methionine metabolism.
(UniProt, P50245)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\AhcyL2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
AhcyL2-RC
FBtr0083378
NM_206500
1780
492
AhcyL2-RD
FBtr0083379
NM_206499
1969
504
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
AhcyL2-PC
FBpp0082821
54.2
492
6.99
NP_996222
AAF55367
AhcyL2-PD
FBpp0089085
55.4
504
7.03
NP_996221
AAS65160
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

527 (aa); 58 (kD predicted)

(de Lorenzi et al., 1988)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AhcyL2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7 -- 8
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
crystal cell
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval midgut
(de Lorenzi et al., 1988)
somatic mesoderm
(de Lorenzi et al., 1988)
Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

AhcyL2 transcripts are first detected in germ band extended embryos. They are later detected in somatic mesoderm and in yolk cells within the midgut.

(de Lorenzi et al., 1988)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AhcyL2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AhcyL2
Transgenic constructs containing regulatory region of AhcyL2
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
long lived | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
long lived | RU486 conditional, with Scer\GAL4TIGS-2
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AHCYL2
11 of 15
Yes
No
1  
Hsap\AHCYL1
10 of 15
No
No
Hsap\AHCY
3 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ahcyl2
11 of 15
Yes
No
Mmus\Ahcyl1
9 of 15
No
No
Mmus\Gm4737
2 of 15
No
No
Mmus\Ahcy
1 of 15
No
No
Mmus\Med16
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Ahcyl2
12 of 13
Yes
Yes
Rnor\Ahcyl1
7 of 13
No
No
Rnor\Ahcy
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ahcyl2
9 of 12
Yes
Yes
Xtro\ahcyl1
7 of 12
No
Yes
Xtro\ahcy
2 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\ahcyl2
11 of 15
Yes
Yes
Drer\ahcyl1
9 of 15
No
No
Drer\zgc:158222
9 of 15
No
No
Drer\ahcy
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ahcy-1
2 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (2)
Atha\HOG1
3 of 9
Yes
No
Atha\SAHH2
3 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SAH1
4 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC8D2.18c
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906PT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009963
Drosophila simulans
Dsim\GD20263
Drosophila sechellia
Dsec\GM15398
Drosophila erecta
Dere\GG16804
Drosophila yakuba
Dyak\GE26121
Drosophila ananassae
Dana\GF17919
Drosophila pseudoobscura pseudoobscura
Dpse\GA27300
Drosophila persimilis
Dper\GL23551
Drosophila willistoni
Dwil\GK13850
Drosophila virilis
Dvir\GJ10596
Drosophila mojavensis
Dmoj\GI23750
Drosophila grimshawi
Dgri\GH18071
Drosophila grimshawi
Dgri\GH23837
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150416 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019720
Musca domestica
House fly
Mdoa\17019180
Glossina morsitans
Tsetse fly
Gmor\GMOY005546
Glossina morsitans
Tsetse fly
Gmor\GMOY000765
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05441
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01958
Mayetiola destructor
Hessian fly
Mdes\Mdes001239
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005524
Anopheles darlingi
American malaria mosquito
Adar\ADAC004431
Anopheles gambiae
Malaria mosquito
Agam\AGAP000792
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011531
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03T9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009808
Danaus plexippus
Monarch butterfly
Dple\DPOGS211994-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009358
Apis florea
Little honeybee
Aflo\4065341220
Apis mellifera
Western honey bee
Amel\GB42203
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25603
Bombus terrestris
Buff-tailed bumblebee
Bter\15207803
Linepithema humile
Argentine ant
Lhum\LH21925
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002978
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008520
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09166
Tribolium castaneum
Red flour beetle
Tcas\TC001438
Pediculus humanus
Human body louse
Phum\PHUM326020
Rhodnius prolixus
Kissing bug
Rpro\RPRC009709
Rhodnius prolixus
Kissing bug
Rpro\RPRC011336
Cimex lectularius
Bed bug
Clec\CLEC006759
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004267
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16899
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03QG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015405
Strigamia maritima
European centipede
Smar\SMAR014428
Ixodes scapularis
Black-legged tick
Isca\ISCW016595
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64892.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g01690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_218555
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06EB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ahcy
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-IrbitL
Ciona intestinalis
Vase tunicate
Cint\LOC100184688
Ciona intestinalis
Vase tunicate
Cint\LOC100183786
Gallus gallus
Domestic chicken
Ggal\AHCY
Gallus gallus
Domestic chicken
Ggal\AHCYL2
Gallus gallus
Domestic chicken
Ggal\AHCYL1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
AhcyL1
7 of 10
Ahcy
5 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AHCYL2; adenosylhomocysteinase like 2
    11 of 15
    616520
         
        AHCYL1; adenosylhomocysteinase like 1
        10 of 15
        607826
            AHCY; adenosylhomocysteinase
            3 of 15
            180960
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            AhcyL2 - AhcyL1
            experimental knowledge based
            (Guruharsha et al., 2011)
            AhcyL2 - Mhcl
            experimental knowledge based
            (Guruharsha et al., 2011)
            AhcyL2 - ssp
            experimental knowledge based
            (Guruharsha et al., 2011)
            AhcyL2 - vers
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-59
            Cytogenetic map
            89E5-89E5
            Sequence location
            3R:16,978,439..16,982,158 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            89E5-89E5
            Limits computationally determined from genome sequence between P{lacW}CSN5L4032 and P{EP}MESK4EP1015
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            89E-89E
            (determined by in situ hybridisation)
            (Caggese et al., 1997)
            Experimentally Determined Recombination Data
            Location

            3-59

            (FlyBase, 2016)

            3-59.0

            (Comeron et al., 2012)

            3-

            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (5)
            Genomic Clones (16)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (31)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: AhcyL2 Ahcy89E

              (Parkhitko et al., 2016)
              Source for database merge of
              Additional comments

              The transcription unit denoted 'pH200' in FBrf0047944 corresponds to Ahcy89E.

              (Whitfield, 1999.1.7)
              Other Comments

              Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

              (Claridge-Chang et al., 2001)

              Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

              (McDonald and Rosbash, 2001)

              The complete sequence of the bithorax complex is available.

              (Martin et al., 1995)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 48 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (12)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (43)