FB2020_01, released Feb 12, 2020

Gene: Dmel\CkIα

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General Information
Symbol
Dmel\CkIα
Species
D. melanogaster
Name
Casein kinase Iα
Annotation Symbol
CG2028
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015024
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Casein kinase Iα (CkIα) encodes a member of the CK1 family of Ser/Thr kinases with a preference for acidic substrates. It is involved in multiple signaling pathways, including Wingless and Hedgehog, that control cell growth and patterning. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

CK1, CK1α, CKI, CK I, CK1alpha

Key Links
Genomic Location
Cytogenetic map
11B7-11B8
Sequence location
X:12,653,626..12,657,834 [+]
Recombination map

1-39

RefSeq locus
NC_004354 REGION:12653626..12657834
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (P54367)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding; protein serine/threonine kinase activity
Predictions / Assertions
ATP binding; protein serine/threonine kinase activity
Summaries
Gene Group (FlyBase)
CK1 KINASES -
The CK1 kinases (Casein Kinase 1 family) share a highly conserved kinase domain. CK1 kinases are serine/threonine kinases with a preference for acidic substrates. The highly variable C-terminal domains are involved in regulating subcellular localization and activity. (Adapted from FBrf0132098, PMID:24825444 and PMID:15722192).
BETA CATENIN DESTRUCTION COMPLEX -
The β-catenin destruction complex is a cytoplasmic protein complex that phosphorylates β-catenin, targeting it for ubiquitin-mediated proteolysis. In the absence of Wnt signaling, the β-catenin destruction complex constitutively suppresses the canonical Wnt signaling pathway by preventing the accumulation of cytoplasmic β-catenin (arm). (Adapted from FBrf0217546).
Pathway (FlyBase)
Negative Regulators of Wnt-TCF Signaling Pathway -
Negative regulators of canonical Wnt signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulation the pathway, resulting in the repression of transcription of hh-responsive genes.
Protein Function (UniProtKB)
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling (PubMed:22095083). Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling (PubMed:11955436, PubMed:11927557, PubMed:22095083). Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh (PubMed:15616566). Together with dco, regulates proteolytic processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing (PubMed:16326393). Inhibits condensin II interphase activity by promoting degradation of the Cap-H2 regulatory subunit and limiting the levels of chromatin-bound Cap-H2 which regulates interphase chromosome organization (PubMed:25723539).
(UniProt, P54367)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\CkIα or the JBrowse view of Dmel\CkIα for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CkIα-RA
FBtr0073682
NM_167331
2133
337
CkIα-RB
FBtr0073680
NM_078585
2791
337
CkIα-RD
FBtr0300380
NM_001169266
2232
337
CkIα-RE
FBtr0340408
NM_001298234
2406
337
CkIα-RF
FBtr0345162
NM_001298235
1997
337
CkIα-RG
FBtr0345163
NM_167332
1997
337
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CkIα-PA
FBpp0073515
39.5
337
9.80
NP_727631
AAN09313
CkIα-PB
FBpp0073513
39.5
337
9.80
NP_511140
AAF48193
CkIα-PD
FBpp0289609
39.5
337
9.80
NP_001162737
ACZ95272
CkIα-PE
FBpp0309354
39.5
337
9.80
NP_001285163
AHN59633
CkIα-PF
FBpp0311372
39.5
337
9.80
NP_001285164
AHN59634
CkIα-PG
FBpp0311373
39.5
337
9.80
NP_727632
AAF48192
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

337 aa isoforms: CkIα-PA, CkIα-PB, CkIα-PD, CkIα-PE, CkIα-PF, CkIα-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification

Phosphorylated. The dephosphorylated kinase is active in the cytoplasm while the active kinase in the nucleus is phosphorylated.

(UniProt, P54367)
Subunit Structure (UniProtKB)

Interacts with cos.

(UniProt, P54367)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CkIα using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with UniProtKB:O16844
(assigned by UniProt )
(Zhang et al., 2005)
protein serine/threonine kinase activity
inferred from direct assay
(Swarup and Verheyen, 2011, Zhang et al., 2006, Matsubayashi et al., 2004, Yanagawa et al., 2002, Santos et al., 1996)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000225966
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
cell morphogenesis
inferred from mutant phenotype
(D'Ambrosio and Vale, 2010)
DNA repair
inferred from direct assay
(Santos et al., 1996)
glucose homeostasis
inferred from mutant phenotype
(Ugrankar et al., 2015)
negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Legent et al., 2012, Zhang et al., 2006, Matsubayashi et al., 2004, Lum et al., 2003, Yanagawa et al., 2002)
negative regulation of smoothened signaling pathway
inferred from mutant phenotype
(Lum et al., 2003)
positive regulation of proteasomal protein catabolic process
inferred from mutant phenotype
(Legent et al., 2012)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Galletti et al., 2009, Yanagawa et al., 2002)
inferred from mutant phenotype
(assigned by ParkinsonsUK-UCL )
(Liu et al., 2002)
protein phosphorylation
inferred from direct assay
(Zhang et al., 2006, Jia et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
negative regulation of canonical Wnt signaling pathway
inferred by curator from GO:0032436
(assigned by ParkinsonsUK-UCL )
(Liu et al., 2002)
inferred from biological aspect of ancestor with PANTHER:PTN000936058
(assigned by GO_Central )
(Gaudet et al., 2011)
peptidyl-serine phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000225966
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Zhang et al., 2006, Santos et al., 1996)
inferred from direct assay
(assigned by UniProt )
(Zhang et al., 2005)
nucleus
inferred from direct assay
(assigned by UniProt )
(Zhang et al., 2005)
inferred from direct assay
(Zhang et al., 2006, Santos et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
beta-catenin destruction complex
inferred from sequence or structural similarity with UniProtKB:P48729
(assigned by ParkinsonsUK-UCL )
(Neurological Gene Annotation Project members, 2014-)
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000225966
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000225966
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Zhang et al., 2006, Santos et al., 1996)
inferred from direct assay
(assigned by UniProt )
(Zhang et al., 2005)
nucleus
inferred from direct assay
(assigned by UniProt )
(Zhang et al., 2005)
inferred from direct assay
(Zhang et al., 2006, Santos et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CkIα in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CkIα
Transgenic constructs containing regulatory region of CkIα
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal | embryonic stage
lethal | larval stage
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | recessive
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
female sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
Other Phenotypes
Allele
behavior defective | recessive
melanotic mass phenotype, with Scer\GAL4SPARC-MI00329-GAL4
neuroanatomy defective | larval stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4GMR.PF
visible | somatic clone
Phenotype manifest in
Allele
eye, with Scer\GAL4GMR.PF
eye | somatic clone
eye disc | somatic clone | third instar larval stage
fat body, with Scer\GAL4SPARC-MI00329-GAL4
ganglion mother cell | larval stage
larval neuroblast | larval stage
melanotic mass, with Scer\GAL4SPARC-MI00329-GAL4
neuromuscular junction, with Scer\GAL4elav-C155
synapse, with Scer\GAL4elav-C155
wing | somatic clone
wing margin bristle | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CSNK1A1
14 of 15
Yes
Yes
 
Hsap\CSNK1A1L
12 of 15
No
Yes
Hsap\CSNK1D
5 of 15
No
No
 
Hsap\CSNK1E
3 of 15
No
No
 
Hsap\LOC400927-CSNK1E
3 of 15
No
No
Hsap\TTBK1
1 of 15
No
No
 
Hsap\TTBK2
1 of 15
No
No
 
Hsap\VRK1
1 of 15
No
No
 
Hsap\VRK2
1 of 15
No
No
Hsap\VRK3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Csnk1a1
12 of 15
Yes
Yes
Mmus\Csnk1d
5 of 15
No
No
Mmus\Csnk1e
4 of 15
No
No
Mmus\Ttbk1
1 of 15
No
No
Mmus\Ttbk2
1 of 15
No
No
Mmus\Vrk1
1 of 15
No
No
Mmus\Vrk2
1 of 15
No
No
Mmus\Vrk3
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Csnk1a1
6 of 13
Yes
Yes
Rnor\Csnk1d
2 of 13
No
No
Rnor\Csnk1e
1 of 13
No
No
Rnor\Ttbk2
1 of 13
No
No
Rnor\Vrk1
1 of 13
No
No
Rnor\Vrk2
1 of 13
No
No
Rnor\Vrk3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\csnk1a1
9 of 12
Yes
Yes
Xtro\csnk1e
4 of 12
No
No
Xtro\csnk1d
3 of 12
No
No
Xtro\ttbk2
1 of 12
No
No
Xtro\vrk1
1 of 12
No
No
Xtro\vrk2
1 of 12
No
No
Xtro\vrk3
1 of 12
No
No
Danio rerio (Zebrafish) (10)
Drer\csnk1a1
12 of 15
Yes
Yes
Drer\csnk1da
5 of 15
No
No
Drer\csnk1db
5 of 15
No
No
Drer\csnk1e
5 of 15
No
No
Drer\ttbk1a
1 of 15
No
No
Drer\ttbk1b
1 of 15
No
No
Drer\ttbk2b
1 of 15
No
No
Drer\vrk1
1 of 15
No
No
Drer\vrk2
1 of 15
No
No
Drer\vrk3
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (87)
Cele\kin-19
12 of 15
Yes
Yes
Cele\kin-20
3 of 15
No
No
Cele\K09E4.1
2 of 15
No
Yes
Cele\Y39G8C.2
2 of 15
No
No
Cele\B0207.7
1 of 15
No
No
Cele\B0218.5
1 of 15
No
No
Cele\C03C10.2
1 of 15
No
No
Cele\C04G2.2
1 of 15
No
No
Cele\C05C12.1
1 of 15
No
No
Cele\C08F8.6
1 of 15
No
No
Cele\C09B9.4
1 of 15
No
No
Cele\C09D4.3
1 of 15
No
No
Cele\C14A4.13
1 of 15
No
No
Cele\C25H3.1
1 of 15
No
No
Cele\C27D8.1
1 of 15
No
No
Cele\C28A5.6
1 of 15
No
No
Cele\C34B2.3
1 of 15
No
No
Cele\C38C3.4
1 of 15
No
No
Cele\C44C10.7
1 of 15
No
Yes
Cele\C45G9.1
1 of 15
No
No
Cele\C49C8.1
1 of 15
No
No
Cele\C50F4.10
1 of 15
No
No
Cele\C55B6.5
1 of 15
No
Yes
Cele\C55B7.10
1 of 15
No
No
Cele\C56C10.6
1 of 15
No
No
Cele\D2024.1
1 of 15
No
No
Cele\D2045.5
1 of 15
No
No
Cele\E02H4.6
1 of 15
No
No
Cele\F16B12.5
1 of 15
No
No
Cele\F16B12.7
1 of 15
No
Yes
Cele\F22F1.2
1 of 15
No
No
Cele\F22H10.1
1 of 15
No
No
Cele\F25F2.1
1 of 15
No
Yes
Cele\F26A1.3
1 of 15
No
Yes
Cele\F26A1.4
1 of 15
No
No
Cele\F32B6.10
1 of 15
No
No
Cele\F33D11.7
1 of 15
No
No
Cele\F35C11.3
1 of 15
No
No
Cele\F36H12.9
1 of 15
No
No
Cele\F38E1.3
1 of 15
No
No
Cele\F39F10.2
1 of 15
No
No
Cele\F39F10.3
1 of 15
No
No
Cele\F41G3.5
1 of 15
No
No
Cele\F53C3.1
1 of 15
No
No
Cele\F54H5.2
1 of 15
No
No
Cele\F56H11.6
1 of 15
No
No
Cele\F59A6.4
1 of 15
No
No
Cele\F59E12.3
1 of 15
No
Yes
Cele\H05L14.1
1 of 15
No
No
Cele\K04C1.5
1 of 15
No
No
Cele\K06H7.8
1 of 15
No
No
Cele\K08H2.5
1 of 15
No
Yes
Cele\K11C4.1
1 of 15
No
No
Cele\M04F3.3
1 of 15
No
No
Cele\M7.7
1 of 15
No
No
Cele\prde-1
1 of 15
No
No
Cele\R10D12.10
1 of 15
No
No
Cele\R13H9.5
1 of 15
No
No
Cele\R13H9.6
1 of 15
No
No
Cele\spe-6
1 of 15
No
No
Cele\T05A7.6
1 of 15
No
No
Cele\T05C12.1
1 of 15
No
No
Cele\T09B4.7
1 of 15
No
No
Cele\T11F8.4
1 of 15
No
No
Cele\T15B12.2
1 of 15
No
No
Cele\T19D12.5
1 of 15
No
No
Cele\tag-191
1 of 15
No
No
Cele\ttbk-2
1 of 15
No
No
Cele\W01B6.2
1 of 15
No
No
Cele\W03G9.5
1 of 15
No
No
Cele\W06F12.3
1 of 15
No
No
Cele\W09C3.1
1 of 15
No
No
Cele\Y38H8A.3
1 of 15
No
No
Cele\Y47G6A.13
1 of 15
No
No
Cele\Y59E9AR.10
1 of 15
No
Yes
Cele\Y65B4A.9
1 of 15
No
No
Cele\Y69F12A.1
1 of 15
No
No
Cele\Y71F9AL.2
1 of 15
No
No
Cele\Y111B2A.27
1 of 15
No
Yes
Cele\ZC373.3
1 of 15
No
No
Cele\ZC581.2
1 of 15
No
No
Cele\ZK354.2
1 of 15
No
No
Cele\ZK354.6
1 of 15
No
No
Cele\ZK507.1
1 of 15
No
No
Cele\ZK507.3
1 of 15
No
No
Cele\ZK596.2
1 of 15
No
No
Cele\ZK666.8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\ADK1
4 of 9
Yes
No
Atha\CKI1
4 of 9
Yes
No
Atha\ckl7
4 of 9
Yes
No
Atha\ckl10
4 of 9
Yes
No
Atha\CKL13
4 of 9
Yes
No
Atha\CK1
3 of 9
No
No
Atha\CKL2
3 of 9
No
No
Atha\ckl5
3 of 9
No
No
Atha\CKL6
3 of 9
No
No
Atha\ckl8
3 of 9
No
No
Atha\ckl12
3 of 9
No
No
Atha\AT4G08800
1 of 9
No
No
Atha\ckl3
1 of 9
No
No
Atha\ckl4
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\HRR25
9 of 15
Yes
No
Scer\YCK1
1 of 15
No
No
Scer\YCK2
1 of 15
No
No
Scer\YCK3
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\hhp1
6 of 12
Yes
No
Spom\hhp2
5 of 12
No
No
Spom\cki1
2 of 12
No
No
Spom\cki2
2 of 12
No
No
Spom\cki3
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190AXE )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\CkIα
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006440
Drosophila simulans
Dsim\GD24797
Drosophila sechellia
Dsec\GM11579
Drosophila erecta
Dere\GG17734
Drosophila yakuba
Dyak\GE17024
Drosophila ananassae
Dana\GF21383
Drosophila pseudoobscura pseudoobscura
Dpse\GA15193
Drosophila persimilis
Dper\GL13140
Drosophila willistoni
Dwil\GK25517
Drosophila virilis
Dvir\GJ15916
Drosophila mojavensis
Dmoj\GI16225
Drosophila grimshawi
Dgri\GH12595
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506HF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17026159
Glossina morsitans
Tsetse fly
Gmor\GMOY011765
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00102
Mayetiola destructor
Hessian fly
Mdes\Mdes007835
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007662
Anopheles darlingi
American malaria mosquito
Adar\ADAC003068
Anopheles gambiae
Malaria mosquito
Agam\AGAP000627
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017982
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017578
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07IJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007304
Bombyx mori
Silkmoth
Bmor\BGIBMGA014220
Danaus plexippus
Monarch butterfly
Dple\DPOGS200797-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200370-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016957
Heliconius melpomene
Postman butterfly
Hmel\HMEL004961
Apis florea
Little honeybee
Aflo\2331144004
Apis florea
Little honeybee
Aflo\2379349796
Apis florea
Little honeybee
Aflo\2147680531
Apis mellifera
Western honey bee
Amel\Csnk1a1
Apis mellifera
Western honey bee
Amel\GB55165
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16186
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14828
Bombus terrestris
Buff-tailed bumblebee
Bter\15209593
Bombus terrestris
Buff-tailed bumblebee
Bter\15205615
Linepithema humile
Argentine ant
Lhum\LH18256
Linepithema humile
Argentine ant
Lhum\LH16762
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c48
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002cde
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018299
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001647
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018300
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05765
Tribolium castaneum
Red flour beetle
Tcas\TC034052
Tribolium castaneum
Red flour beetle
Tcas\TC012576
Pediculus humanus
Human body louse
Phum\PHUM327780
Pediculus humanus
Human body louse
Phum\PHUM456320
Rhodnius prolixus
Kissing bug
Rpro\dbt
Cimex lectularius
Bed bug
Clec\CLEC000485
Cimex lectularius
Bed bug
Clec\CLEC000706
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008162
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007630
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03873
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04955
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07DP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013208
Strigamia maritima
European centipede
Smar\SMAR015418
Ixodes scapularis
Black-legged tick
Isca\ISCW002293
Ixodes scapularis
Black-legged tick
Isca\ISCW007936
Ixodes scapularis
Black-legged tick
Isca\ISCW001795
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71835.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73238.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g06080
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00680
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_232195
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301140
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AFG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ck1a2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ck1d
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ck1a1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006500
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002874
Ciona intestinalis
Vase tunicate
Cint\LOC100177660
Gallus gallus
Domestic chicken
Ggal\CSNK1A1
Gallus gallus
Domestic chicken
Ggal\CSNK1D
Gallus gallus
Domestic chicken
Ggal\CSNK1E
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (11)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
dco
7 of 10
CG2577
4 of 10
CG7094
4 of 10
CG9962
4 of 10
CG12147
4 of 10
Asator
3 of 10
ball
3 of 10
CG8878
3 of 10
gish
2 of 10
Cdc7
1 of 10
CG5790
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CSNK1A1; casein kinase 1 alpha 1
    14 of 15
    600505
         
        CSNK1A1L; casein kinase 1 alpha 1 like
        12 of 15
            CSNK1D; casein kinase 1 delta
            5 of 15
            600864
             
            CSNK1E; casein kinase 1 epsilon
            3 of 15
            600863
                 
                Hsap\LOC400927-CSNK1E
                3 of 15
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    brat
                    enhanceable
                    CkIα
                    (Komori et al., 2014)
                    dco
                    enhanceable
                    CkIα
                    (Strutt et al., 2006)
                    H
                    suppressible
                    CkIα
                    (Müller et al., 2005)
                    External Data
                    Subunit Structure (UniProtKB)
                    Interacts with cos.
                    (UniProt, P54367 )
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Negative Regulators of Wnt-TCF Signaling Pathway -
                    Negative regulators of canonical Wnt signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
                    Negative Regulators of Hedgehog Signaling Pathway -
                    Negative regulators of hedgehog signaling down-regulation the pathway, resulting in the repression of transcription of hh-responsive genes.
                    Metabolic Pathways
                    External Data
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    X
                    Recombination map

                    1-39

                    Cytogenetic map
                    11B7-11B8
                    Sequence location
                    X:12,653,626..12,657,834 [+]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    11B7-11B8
                    Limits computationally determined from genome sequence between P{EP}CG11138EP1313 and P{EP}EP1632&P{EP}EP1449
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    11B13-11B16
                    (determined by in situ hybridisation)
                    (Peter et al., 2002, Schäfer et al., 1999.12.14)
                    11B4-11B14
                    (Santos, 1996.1.4)
                    Experimentally Determined Recombination Data
                    Location

                    1-39

                    (FlyBase, 2016)

                    1-39.6

                    (Comeron et al., 2012)

                    1-

                    (Santos, 1996.1.4)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (14)
                    Genomic Clones (12)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (219)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequences
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: CkIα CG2028

                    (Ke, 1999.11)
                    Source for database merge of

                    Source for merge of: CkIα l(1)G0492

                    (Peter et al., 2002)

                    Source for merge of: CkIα anon-WO03040301.93 anon-WO03040301.95

                    (FlyBase, 1996-)
                    Additional comments

                    Source for merge of CkIα anon-WO03040301.93 anon-WO03040301.95 was sequence comparison ( date:051113 ).

                    (FlyBase, 1996-)
                    Other Comments

                    dsRNA made from templates generated with primers directed against CkIα profoundly increases the wg-signaling pathway.

                    (Seto and Bellen, 2006)

                    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                    (Stroschein-Stevenson et al., 2006)

                    The dco and CkIα products act additively to provide optimal kinase activity required for efficient ci protein phosphorylation and processing.

                    (Jia et al., 2005)

                    When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells and a a decrease in cell size is seen.

                    (Bettencourt-Dias et al., 2004)

                    CkIα phosphorylates arm and may stimulate its degradation.

                    (Yanagawa et al., 2002)

                    CkIα protein is isolated and characterised.

                    (Santos et al., 1996)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 80 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DPiM - Drosophila Protein interaction map
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (39)
                    Reported As
                    Symbol Synonym
                    CG2028
                    (Çiçek et al., 2016, Hosono et al., 2015, Fukuoh et al., 2014, Haelterman et al., 2014, Schertel et al., 2013, Ni et al., 2011.7.19, Buechling et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009.1.15, Morrison et al., 2000)
                    CK I
                    (Weber et al., 2007, Behrens, 2000, Horiuchi et al., 2000)
                    CK1
                    (Zhao et al., 2017, Bejsovec, 2013, Spratford and Kumar, 2013, Zhou and Kalderon, 2011, Jia et al., 2009, Smelkinson et al., 2007, Tolwinski, 2007, Zhao et al., 2007, Smelkinson and Kalderon, 2006, Smelkinson and Kalderon, 2006, Kalderon, 2005, Torroja et al., 2005, Lum and Beachy, 2004, Ou et al., 2003, Price et al., 2003, Wharton, 2003, Lefers and Holmgren, 2002, Nybakken and Perrimon, 2002)
                    CK1a
                    (Buechling et al., 2011, Zhang et al., 2005)
                    CK1alpha
                    (Mbodj et al., 2013, Ding and Dale, 2002, Kalderon, 2002)
                    CK1α
                    (Li et al., 2016, Shi et al., 2014, Legent et al., 2012, Shi et al., 2011, Buechling et al., 2010, Galletti et al., 2009, Mennella et al., 2009, Bjorklund et al., 2006, Fearon and Cadigan, 2005, Lum et al., 2003)
                    CKI
                    (Zouaz et al., 2018, Xiong et al., 2015, Price et al., 2007, Tountas and Fortini, 2007, Heeg-Truesdell, 2006, Stadeli, 2006, Ishii, 2005, Bienz and Hamada, 2004, Jiang, 2002)
                    CKI α
                    (Takada et al., 2005)
                    CKIa
                    (Di Cara et al., 2015, Morrison et al., 2000)
                    CKIalpha
                    (Lindquist et al., 2011, Blanco et al., 2010)
                    CKIα
                    (Kanoh et al., 2015, Kim et al., 2014, Komori et al., 2014, Lindquist et al., 2011, Zhou and Kalderon, 2011, D'Ambrosio and Vale, 2010, Feng and Irvine, 2009, Strutt et al., 2006, Zhang et al., 2006, Jia et al., 2005, Jia et al., 2004, Matsubayashi et al., 2004, Bussell, 2003, Polakis, 2002, Yanagawa et al., 2002)
                    Ck1alpha
                    (Ugrankar et al., 2018)
                    Ck1α
                    (Tsai and Galko, 2019, Choi et al., 2014)
                    CkI α
                    (Yin et al., 2013)
                    CkIa
                    (Pospisilik et al., 2010, Peter et al., 2002)
                    CkIalpha
                    (Song et al., 2017, Ugrankar et al., 2015, Nybakken, 2014.2.28, Sopko et al., 2014, Bonke et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Yamamoto et al., 2013-, Zhang et al., 2013, Friedman et al., 2011, Toku et al., 2011, Popodi et al., 2010-, Venken et al., 2010, Wasbrough et al., 2010, Giot et al., 2003)
                    CkIα
                    (Tan et al., 2016, Bouleau and Tricoire, 2015, Kanoh et al., 2015, Zang et al., 2015, Haelterman et al., 2014, Briscoe and Thérond, 2013, Kanao et al., 2012, Bai et al., 2007, Liu et al., 2007, Stroschein-Stevenson et al., 2006, Furlong, 2005, Nybakken et al., 2005, Zhang et al., 2005)
                    PKA-C
                    (Matsubayashi et al., 2004)
                    anon-WO03040301.93
                    anon-WO03040301.95
                    ck1a
                    (Seto and Bellen, 2006)
                    ck1α
                    (DasGupta et al., 2005)
                    ckI
                    (Fulford et al., 2019)
                    ckIα
                    (Fulford et al., 2019)
                    dmCK1
                    (Santos et al., 1996)
                    dmckI
                    (Santos, 1996.1.4)
                    l(1)G0492
                    (Schäfer et al., 1999.12.14)
                    Name Synonyms
                    Casein Kinase 1
                    (Stadeli, 2006, Apionishev et al., 2005, Torroja et al., 2005)
                    Casein Kinase 1α
                    (Legent et al., 2012)
                    Casein kinase 1
                    (Santos et al., 1996)
                    Casein kinase I
                    (Tountas and Fortini, 2007, Marques, 2005)
                    Casein kinase Ialpha
                    (Nybakken, 2014.2.28)
                    Casein kinase Iα
                    (Edwards et al., 2009, Cadigan, 2002)
                    caesin kinase I α
                    (D'Ambrosio and Vale, 2010)
                    casein kinase 1
                    (Smelkinson and Kalderon, 2006)
                    casein kinase 1a
                    (Seto and Bellen, 2006)
                    casein kinase I
                    (Bienz and Hamada, 2004)
                    casein kinase Iα
                    (Kanoh et al., 2015, Matsubayashi et al., 2004)
                    casein kinase-1
                    (Spratford and Kumar, 2013)
                    Secondary FlyBase IDs
                    • FBgn0029043
                    • FBgn0066807
                    • FBgn0066808
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (177)