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Gene Dmel\CkIα

General Information
Symbol	Dmel\CkIα	Species	D. melanogaster
Name	Casein kinase Iα	Annotation symbol	CG2028
Feature type	protein_coding_gene	FlyBase ID	FBgn0015024
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	CK1, CKI, CK1α, CkIalpha, CkIa, CK I, CK1alpha, CK1a
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	11B7-11B7	Sequence location	X:12,547,816..12,551,867 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Casein kinase Iα is referred to in FlyBase by the symbol Dmel\CkIα (CG2028, FBgn0015024). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; regulation of Wnt receptor signaling pathway; DNA repair; protein phosphorylation; negative regulation of smoothened signaling pathway; cell morphogenesis; neurogenesis; phagocytosis, engulfment. 27 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; ventral nerve cord commissure; eye; embryonic epidermis; longitudinal connective. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult heart, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623403_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of CkIalpha. Gene sequence location is X:12547816..12551867.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms cell morphogenesis Sequence features HFA20231 BKN50737 BKN51078 BKN27574 References D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478
FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11B7-11B7   Limits computationally determined from genome sequence between P{EP}CG11138EP1313 and P{EP}EP1632&P{EP}EP1449
Experimentally Determined Cytological Location
Cytogenetic map Notes References 11B13-11B16   (determined by in situ hybridisation)   (Peter et al., 2002) 11B13-11B16   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.14) 11B4-11B14     (Santos, 1996.1.4)
Experimentally Determined Recombination Data
Location	1- (Santos, 1996.1.4)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CkIα for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CkIα-RA FBtr0073682  NM_167331   2077   337 CkIα-RB FBtr0073680  NM_078585   2808   337 CkIα-RC FBtr0073681  NM_167332   1918   337 CkIα-RD FBtr0300380  NM_001169266   2249   337
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CkIα-PA   FBpp0073515   39.5   337   9.80     NP_727631   AAN09313 CkIα-PB   FBpp0073513   39.5   337   9.80     NP_511140   AAF48193 CkIα-PC   FBpp0073514   39.5   337   9.80     NP_727632   AAF48192 CkIα-PD   FBpp0289609   39.5   337   9.80     NP_001162737   ACZ95272
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201361   AA202902   AA246663   AA263274   AA263920   AA264122   AA264539   AA390926   AA391192   AA391661   AA392015   AA392058   AA392510   AA441489   AA538981   AA539489   AA816750   AA816875   AA978952   AE014298 AAF48192   AE014298 AAF48193   AE014298 AAN09313   AE014298 ACZ95272   AI063860   AI107681   AI134693   AI259375   AI297571   AI512357   AI512504   AI515490   AI945875   AJ426882   AQ025495   AW942057   AX777239   AX777241   AY069346 AAL39491   BG635416   BG637385   BI164151   BI164601   BI166273   BI168212   BI170431   BI173206   BI173465   BI213150   BI228305   BI229289   BI230484   BI230633   BI230789   BI230839   BI232236   BI233076   BI235534   BI235717   BI236057   BI236214   BI356796   BI357872   BI363881   BI363899   BI365440   BI365456   BI367996   BI368736   BI368784   BI373047   BI482220   BI482288   BI485123   BI566053   BI579576   BI580442   BI583224   BI588897   BI608087   BI619784   BI624796   BI628621   BI629036   BI637655   BP548151   BP555347   BP555348   CK657260   CO154150   CO155226   CO156239   CO156452   CO176752   CO177251   CO177387   CO179359   CO179693   CO179724   CO185459   CO186078   CO262616   CO262627   CO264193   CO265077   CO266012   CO267394   CO270186   CO270486   CO270759   CO271151   CO272025   CO272183   CO272632   CO272823   CO273365   CO279053   CO279707   CO279755   CO282040   CO282385   CO284025   CO285705   CO288107   CO288344   CO289640   CO289687   CO289690   CO290626   CO291005   CO291595   CO291951   CO294912   CO295550   CO300110   CO300974   CO302322   CO303118   CO303418   CO303443   CO303627   CO304071   CO305022   CO305081   CO305979   CO306581   CO310296   CO311024   CO312922   CO315475   CO315926   CO319020   CO321164   CO321266   CO322489   CO323616   CO326510   CO327527   CO328205   CO328921   CO329860   CO331919   CO332915   CO332941   CO333856   CO334021   CO338904   CO339189   CO340794   CO341019   CO341263   CO341919   CO341957   CO342945   CO345363   CZ472330   EC055457   EC057337   EC058998   EC062188   EC064796   EC065066   EC065792   EC066993   EC069647   EC069951   EC069958   EC070151   EC070952   EC076978   EC077074   EC077830   EC079306   EC079904   EC084326   EC085512   EC086874   EC086935   EC088475   EC088578   EC090591   EC090822   EC196175   EC197922   EC198367   EC198778   EC198826   EC200666   EC201067   EC201612   EC202063   EC203277   EC204197   EC204640   EC205621   EC206320   EC206647   EC209279   EC212351   EC213723   EC214248   EC215264   EC215879   EC216508   EC218799   EC219124   EC219236   EC220404   EC220798   EC221247   EC221376   EC222027   EC222402   EC223517   EC224606   EC226059   EC226364   EC226981   EC227813   EC228256   EC229219   EC230117   EC230940   EC230941   EC232842   EC232880   EC234439   EC235183   EC235202   EC236494   EC236677   EC241751   EC242853   EC243187   EC243526   EC244126   EC246044   EC254760   EC255405   EC255944   EC257048   EC257088   EC257107   EC257574   EC257609   EC257640   EC258311   EC259182   EC259831   EC260107   EC263849   EC265773   ES688783   ES688858   ES689109   ES689178   ES689190   ES689703   ES691064   EV578014   EV592692   EV595679   EV595966   EV596265   EV596330   EV596728   EV597490   EV598987   EV599149   GH777698   GH806431   U55848 AAB16904   X94695 CAA64358
UniProtKB/Swiss-Prot	P54367
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015024    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015024 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015024 expression level Developmental Stage   Expression Level embryo 00-02hr    9519 embryo 02-04hr    15716 embryo 04-06hr    15380 embryo 06-08hr    12436 embryo 08-10hr    12638 embryo 10-12hr    11415 embryo 12-14hr    10762 embryo 14-16hr    9441 embryo 16-18hr    9039 embryo 18-20hr    6494 embryo 20-22hr    6900 embryo 22-24hr    7436 larva L1    3728 larva L2    3638 larva L3 12hr old    2843 larva L3 puffstage 1-2    3182 larva L3 puffstage 3-6    5300 larva L3 puffstage 7-9    7717 white prepupae new    9286 white prepupae 12hr    7472 white prepupae 24hr    7217 pupae 2d postWPP    6920 pupae 3d postWPP    6225 pupae 4d postWPP    5115 adult male 01day    5550 adult male 05day    4716 adult male 30day    3662 adult female 01day    6234 adult female 05day    7671 adult female 30day    6722 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9519) embryo 02-04hr  (15716) embryo 04-06hr  (15380) embryo 06-08hr  (12436) embryo 08-10hr  (12638) embryo 10-12hr  (11415) embryo 12-14hr  (10762) embryo 14-16hr  (9441) embryo 16-18hr  (9039) embryo 18-20hr  (6494) embryo 20-22hr  (6900) embryo 22-24hr  (7436) larva L1  (3728) larva L2  (3638) larva L3 12hr old  (2843) larva L3 puffstage 1-2  (3182) larva L3 puffstage 3-6  (5300) larva L3 puffstage 7-9  (7717) white prepupae new  (9286) white prepupae 12hr  (7472) white prepupae 24hr  (7217) pupae 2d postWPP  (6920) pupae 3d postWPP  (6225) pupae 4d postWPP  (5115) adult male 01day  (5550) adult male 05day  (4716) adult male 30day  (3662) adult female 01day  (6234) adult female 05day  (7671) adult female 30day  (6722) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9519) embryo 02-04hr  (15716) embryo 04-06hr  (15380) embryo 06-08hr  (12436) embryo 08-10hr  (12638) embryo 10-12hr  (11415) embryo 12-14hr  (10762) embryo 14-16hr  (9441) embryo 16-18hr  (9039) embryo 18-20hr  (6494) embryo 20-22hr  (6900) embryo 22-24hr  (7436) larva L1  (3728) larva L2  (3638) larva L3 12hr old  (2843) larva L3 puffstage 1-2  (3182) larva L3 puffstage 3-6  (5300) larva L3 puffstage 7-9  (7717) white prepupae new  (9286) white prepupae 12hr  (7472) white prepupae 24hr  (7217) pupae 2d postWPP  (6920) pupae 3d postWPP  (6225) pupae 4d postWPP  (5115) adult male 01day  (5550) adult male 05day  (4716) adult male 30day  (3662) adult female 01day  (6234) adult female 05day  (7671) adult female 30day  (6722) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9519 embryo 02-04hr  (15716) embryo 04-06hr  (15380) embryo 06-08hr  (12436) embryo 08-10hr  (12638) embryo 10-12hr  (11415) embryo 12-14hr  10762 embryo 14-16hr    9441 embryo 16-18hr    9039 embryo 18-20hr    6494 embryo 20-22hr    6900 embryo 22-24hr    7436 larva L1    3728 larva L2    3638 larva L3 12hr old    2843 larva L3 puffstage 1-2    3182 larva L3 puffstage 3-6    5300 larva L3 puffstage 7-9    7717 white prepupae new    9286 white prepupae 12hr    7472 white prepupae 24hr    7217 pupae 2d postWPP    6920 pupae 3d postWPP    6225 pupae 4d postWPP    5115 adult male 01day    5550 adult male 05day    4716 adult male 30day    3662 adult female 01day    6234 adult female 05day    7671 adult female 30day    6722 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9519 embryo 02-04hr    15716 embryo 04-06hr    15380 embryo 06-08hr    12436 embryo 08-10hr    12638 embryo 10-12hr    11415 embryo 12-14hr    10762 embryo 14-16hr    9441 embryo 16-18hr    9039 embryo 18-20hr    6494 embryo 20-22hr    6900 embryo 22-24hr    7436 larva L1    3728 larva L2    3638 larva L3 12hr old    2843 larva L3 puffstage 1-2    3182 larva L3 puffstage 3-6    5300 larva L3 puffstage 7-9    7717 white prepupae new    9286 white prepupae 12hr    7472 white prepupae 24hr    7217 pupae 2d postWPP    6920 pupae 3d postWPP    6225 pupae 4d postWPP    5115 adult male 01day    5550 adult male 05day    4716 adult male 30day    3662 adult female 01day    6234 adult female 05day    7671 adult female 30day    6722 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015024 expression level Developmental Stage   Expression Level embryo 00-02hr    9519 embryo 02-04hr    15716 embryo 04-06hr    15380 embryo 06-08hr    12436 embryo 08-10hr    12638 embryo 10-12hr    11415 embryo 12-14hr    10762 embryo 14-16hr    9441 embryo 16-18hr    9039 embryo 18-20hr    6494 embryo 20-22hr    6900 embryo 22-24hr    7436 larva L1    3728 larva L2    3638 larva L3 12hr old    2843 larva L3 puffstage 1-2    3182 larva L3 puffstage 3-6    5300 larva L3 puffstage 7-9    7717 white prepupae new    9286 white prepupae 12hr    7472 white prepupae 24hr    7217 pupae 2d postWPP    6920 pupae 3d postWPP    6225 pupae 4d postWPP    5115 adult male 01day    5550 adult male 05day    4716 adult male 30day    3662 adult female 01day    6234 adult female 05day    7671 adult female 30day    6722 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9519) embryo 02-04hr  (15716) embryo 04-06hr  (15380) embryo 06-08hr  (12436) embryo 08-10hr  (12638) embryo 10-12hr  (11415) embryo 12-14hr  (10762) embryo 14-16hr  (9441) embryo 16-18hr  (9039) embryo 18-20hr  (6494) embryo 20-22hr  (6900) embryo 22-24hr  (7436) larva L1  (3728) larva L2  (3638) larva L3 12hr old  (2843) larva L3 puffstage 1-2  (3182) larva L3 puffstage 3-6  (5300) larva L3 puffstage 7-9  (7717) white prepupae new  (9286) white prepupae 12hr  (7472) white prepupae 24hr  (7217) pupae 2d postWPP  (6920) pupae 3d postWPP  (6225) pupae 4d postWPP  (5115) adult male 01day  (5550) adult male 05day  (4716) adult male 30day  (3662) adult female 01day  (6234) adult female 05day  (7671) adult female 30day  (6722) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9519) embryo 02-04hr  (15716) embryo 04-06hr  (15380) embryo 06-08hr  (12436) embryo 08-10hr  (12638) embryo 10-12hr  (11415) embryo 12-14hr  (10762) embryo 14-16hr  (9441) embryo 16-18hr  (9039) embryo 18-20hr  (6494) embryo 20-22hr  (6900) embryo 22-24hr  (7436) larva L1  (3728) larva L2  (3638) larva L3 12hr old  (2843) larva L3 puffstage 1-2  (3182) larva L3 puffstage 3-6  (5300) larva L3 puffstage 7-9  (7717) white prepupae new  (9286) white prepupae 12hr  (7472) white prepupae 24hr  (7217) pupae 2d postWPP  (6920) pupae 3d postWPP  (6225) pupae 4d postWPP  (5115) adult male 01day  (5550) adult male 05day  (4716) adult male 30day  (3662) adult female 01day  (6234) adult female 05day  (7671) adult female 30day  (6722) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9519 embryo 02-04hr  15716 embryo 04-06hr  15380 embryo 06-08hr  12436 embryo 08-10hr  12638 embryo 10-12hr  11415 embryo 12-14hr  10762 embryo 14-16hr    9441 embryo 16-18hr    9039 embryo 18-20hr    6494 embryo 20-22hr    6900 embryo 22-24hr    7436 larva L1    3728 larva L2    3638 larva L3 12hr old    2843 larva L3 puffstage 1-2    3182 larva L3 puffstage 3-6    5300 larva L3 puffstage 7-9    7717 white prepupae new    9286 white prepupae 12hr    7472 white prepupae 24hr    7217 pupae 2d postWPP    6920 pupae 3d postWPP    6225 pupae 4d postWPP    5115 adult male 01day    5550 adult male 05day    4716 adult male 30day    3662 adult female 01day    6234 adult female 05day    7671 adult female 30day    6722 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9519 embryo 02-04hr    15716 embryo 04-06hr    15380 embryo 06-08hr    12436 embryo 08-10hr    12638 embryo 10-12hr    11415 embryo 12-14hr    10762 embryo 14-16hr    9441 embryo 16-18hr    9039 embryo 18-20hr    6494 embryo 20-22hr    6900 embryo 22-24hr    7436 larva L1    3728 larva L2    3638 larva L3 12hr old    2843 larva L3 puffstage 1-2    3182 larva L3 puffstage 3-6    5300 larva L3 puffstage 7-9    7717 white prepupae new    9286 white prepupae 12hr    7472 white prepupae 24hr    7217 pupae 2d postWPP    6920 pupae 3d postWPP    6225 pupae 4d postWPP    5115 adult male 01day    5550 adult male 05day    4716 adult male 30day    3662 adult female 01day    6234 adult female 05day    7671 adult female 30day    6722 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015024    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015024 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult heart, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015024 expression level Tissue   Expression Level Larval Central Nervous System    592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye    938.275 Adult Brain    789 Adult Thoracic-Abdominal Ganglion    669.3 Adult Crop    525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart    625.775 Adult VirginFemale Spermatheca    753.5 Adult InseminatedFemale Spermatheca    634.4 Adult Ovary    574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (592.925) Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye  (938.275) Adult Brain  (789) Adult Thoracic-Abdominal Ganglion  (669.3) Adult Crop  525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart  (625.775) Adult VirginFemale Spermatheca  (753.5) Adult InseminatedFemale Spermatheca  (634.4) Adult Ovary  (574.1) Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye    938.275 Adult Brain    789 Adult Thoracic-Abdominal Ganglion    669.3 Adult Crop    525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart    625.775 Adult VirginFemale Spermatheca    753.5 Adult InseminatedFemale Spermatheca    634.4 Adult Ovary    574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye    938.275 Adult Brain    789 Adult Thoracic-Abdominal Ganglion    669.3 Adult Crop    525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart    625.775 Adult VirginFemale Spermatheca    753.5 Adult InseminatedFemale Spermatheca    634.4 Adult Ovary    574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015024 expression level Tissue   Expression Level Larval Central Nervous System    592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye    938.275 Adult Brain    789 Adult Thoracic-Abdominal Ganglion    669.3 Adult Crop    525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart    625.775 Adult VirginFemale Spermatheca    753.5 Adult InseminatedFemale Spermatheca    634.4 Adult Ovary    574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye  (938.275) Adult Brain  789 Adult Thoracic-Abdominal Ganglion  669.3 Adult Crop  525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart  625.775 Adult VirginFemale Spermatheca  753.5 Adult InseminatedFemale Spermatheca  634.4 Adult Ovary  574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye    938.275 Adult Brain    789 Adult Thoracic-Abdominal Ganglion    669.3 Adult Crop    525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart    625.775 Adult VirginFemale Spermatheca    753.5 Adult InseminatedFemale Spermatheca    634.4 Adult Ovary    574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    592.925 Larval Midgut    334 Larval Hindgut    416.5 Larval Malpighian Tubules    399.9 Larval Fat Body    304.7 Larval Salivary Gland    376.1 Larval Trachea    491.625 Larval Carcass    378.25 Adult Head    461.3 Adult Eye    938.275 Adult Brain    789 Adult Thoracic-Abdominal Ganglion    669.3 Adult Crop    525.6 Adult Midgut    248.2 Adult Hindgut    322.9 Adult Malpighian Tubules    358.5 Adult Fat Body    455.8 Adult Salivary Gland    318.3 Adult Heart    625.775 Adult VirginFemale Spermatheca    753.5 Adult InseminatedFemale Spermatheca    634.4 Adult Ovary    574.1 Adult Testis    117.4 Adult Male Accessory Gland    282.7 Adult Carcass    219.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    461.3   NA  Eye    938.275   NA  Brain    789   592.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    669.3   NA  Crop    525.6   334  Midgut    248.2   416.5  Hindgut    322.9   399.9  Malpighian Tubules    358.5   304.7  Fat Body    455.8   376.1  Salivary Gland    318.3   NA  Heart    625.775   491.625  Trachea    NA   NA  VirginFemale Spermatheca    753.5   NA  InseminatedFemale Spermatheca    634.4   NA  Ovary    574.1   NA  Testis    117.4   NA  Male Accessory Gland    282.7   378.25  Carcass    219.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015024 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2028-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CkIαGD4256 lethal | pupal stage, with Scer\GAL4pnr-MD237 CkIαGD4256 semi-lethal | recessive CkIαG0492 Sterility Allele female sterile CkIαG0492 Other Phenotypes Allele behavior defective | recessive CkIαBG01498 neuroanatomy defective CkIαdsRNA.cIa neuroanatomy defective | larval stage, with Scer\GAL41407 CkIαGD4256 visible, with Scer\GAL4GMR.PF CkIαEP1555 Phenotype manifest in Allele embryonic/first instar larval cuticle CkIαdsRNA.cLa CkIαdsRNA.cYa embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CkIαGD4256 embryonic epidermis CkIαdsRNA.cYa eye, with Scer\GAL4GMR.PF CkIαEP1555 ganglion mother cell | larval stage, with Scer\GAL41407 CkIαGD4256 longitudinal connective CkIαdsRNA.cIa ventral nerve cord commissure CkIαdsRNA.cIa wing margin bristle | ectopic, with Scer\GAL4Bx-MS1096 CkIαdsRNA.Scer\UAS
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CkIα Class Mutagen Stocks Known lesion CkIαd01603 P-element activity 1 -- CkIαEP1555 P-element activity 1 -- CkIαG0492 P-element activity 1 -- CkIαBG01498 0 -- CkIαGG01591 0 --
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CkIα Class Mutagen Stocks Known lesion CkIαGD4256 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIαGL00021 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIαJF01792 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIαAct5C.PL in vitro construct - regulatory fusion 0 Yes CkIαdsRNA.320 in vitro construct - RNAi 0 Yes CkIαdsRNA.400 in vitro construct - RNAi 0 Yes CkIαdsRNA.440 in vitro construct - RNAi 0 Yes CkIαdsRNA.744 in vitro construct - RNAi 0 Yes CkIαdsRNA.cIa in vitro construct - RNAi 0 Yes CkIαdsRNA.cLa in vitro construct - RNAi 0 -- CkIαdsRNA.CRL.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes CkIαdsRNA.CRS2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes CkIαdsRNA.cYa in vitro construct - RNAi 0 Yes CkIαdsRNA.Scer\UAS.cAa in vitro construct - RNAi 0 Yes CkIαdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes CkIαdsRNA.WIZ.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes CkIαK49R.Act5C.PL in vitro construct - site directed mutagenesis 0 Yes CkIαKK107574 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CkIαKN.MtnA.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes CkIαMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CkIαScer\UAS.T:Avic\GFP-CFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes CkIαScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC257 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-CkIα.dsRNA} NA P{UAS-CkIα.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CkIαEP1555 NA P{Mae-UAS.6.11}CkIαGG01591 NA P{XP}CkIαd01603 NA insertion of enhancer trap P{lacW}CkIαG0492 No miscellaneous insertions P{GT1}CkIαBG01498 NA
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein kinase activity inferred from direct assay (Santos et al., 1996)
Biological Process
CV term Evidence References
cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) DNA repair inferred from direct assay (Santos et al., 1996) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) negative regulation of smoothened signaling pathway inferred from mutant phenotype (Lum et al., 2003) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) protein phosphorylation inferred from direct assay (Jia et al., 2005) regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Zhang et al., 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Santos et al., 1996, Zhang et al., 2006) nucleus inferred from direct assay (Santos et al., 1996, Zhang et al., 2006)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity (Santos et al., 1996) inferred from sequence or structural similarity with UniProtKB:P48729 (FlyBase, 1992-) non-traceable author statement (Santos, 1996.1.4, Morrison et al., 2000, Swiss-Prot Project Members, 1996.10.1)
Biological Process
CV term Evidence References
protein catabolic process non-traceable author statement (Cadigan, 2002) protein phosphorylation non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1996.10.1) regulation of proteolysis traceable author statement (Jiang, 2002) smoothened signaling pathway traceable author statement (Bussell, 2003) Wnt receptor signaling pathway traceable author statement (Bussell, 2003)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CkIα allele Gene References unspecified dco (Strutt et al., 2006) grim (Mueller et al., 2005) H (Mueller et al., 2005) rpr (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58615 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015024 DroID - A comprehensive database of gene and protein interactions. • FBgn0015024 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32221
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21383 Dere\GG17734 Dgri\GH12595 Dmoj\GI16225 Dper\GL13140 Dpse\GA15193 Dsec\GM11579 Dvir\GJ15916 Dwil\GK25517 Dyak\GE17024
Curated drosophilid orthologs	Dpse\GA15193
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007662-PA Aedes aegypti (mosquito) AGAP000627-PA Anopheles gambiae (mosquito) XP_393612.2 Apis mellifera (honey bee) 107521 Branchiostoma floridae (lancelet) BGIBMGA014220-PA Bombyx mori (silk worm) ENSBTAP00000040522 Bos taurus (bovine) CN17884 Caenorhabditis brenneri (small nematode) CBP04738 Caenorhabditis briggsae (nematode) CE00872 Caenorhabditis elegans (worm) ENSCINP00000016371 Ciona intestinalis (sea squirt) JA09517 Caenorhabditis japonica (nematode) CPIJ017578 Culex pipens (mosquito) CPIJ017982 Culex pipens (mosquito) ENSCPOP00000000957 Cavia porcellus (guinea pig) RP23783 Caenorhabditis remanei (nematode) ENSCSAVP00000001596 Ciona savignyi (sedentary tunicate) 20777 Capitella spl (polychaete worm) 301140 Daphnia pulex (daphnia) ENSDARP00000027892 Danio rerio (zebra fish) ENSDARP00000069059 Danio rerio (zebra fish) ENSECAP00000003397 Equus caballus (horse) ENSGACP00000025886 Gymnopilus aculeatus (mushroom) ENSGALP00000002080 Gallus gallus (chicken) GL50803_7537 Giardia lamblia (flagellated protozoan) 186278 Hypsipyla robusta (cedar shoot borer) ENSP00000261798 Homo sapiens (human) ISCW001795-PA Ixodes scapularis (deer tick) 204147 Lottia gigantea (owl limpet) ENSMODP00000038028 Monodelphis domestica (gray opossum) ENSMMUP00000033886 Macaca mulatta (rhesus monkey) ENSMUSP00000110901 Mus musculus (house mouse) 161273 Nematostella vectensis (starlet anemone) XP_001607697.1 Nasonia vitripennis (wasp) ENSORLP00000025560 Oryzias latipes (japanese killifish) PHUM000065-PA Pediculus humanus (human body louse) PP24697 Pristionchus pacificus (nematode) ENSPPYP00000006028 Pongo pygmaeus (orangutan) ENSPTRP00000047919 Pan troglodytes (chimpanzee) ENSRNOP00000051516 Rattus norvegicus (norway rat) Smp_067810 Schistosoma mansoni (trematode parasite) XP_786391.1 Strongylocentrotus purpuratus (purple sea urchin) 50603 Trichoplax adhaerens (metazoa) XP_973313.2 Tribolium castaneum (red flour beetle) ENSTRUP00000000684 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000045038 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10764 LH18256 ISCW007936 ISCW001795 FBgn0234510 FBgn0227476 FBgn0203103 FBgn0166522 JGI_V11_301140 FBgn0075218 FBgn0150746 FBgn0138974 FBgn0120074 FBgn0109956 FBgn0098385 CPIJ017578 CPIJ017982 BGIBMGA014220 GB10720 AGAP000627 AAEL007662 PB25361 PHUM456320 GLEAN_12576
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	25786 y1 v1; P{TRiP.JF01792}attP2 12303 w67c23 P{lacW}CkIαG0492/FM7c 35153 y1 sc* v1; P{TRiP.GL00021}attP2 17009 w1118 P{EP}CkIαEP1555 EP1555EP1555
Harvard	- P{XP}CkIαd01603
VDRC	v13664 w1118; P{GD4256}v13664
Genomic Clones ( 2 )
	BACR23O09 BACR39P03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 276 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05574
Other clones	DPiM_LD05574
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03961 GH05493 LD03318 LD04362 LD06364 LD06426 LD07166 LD07618 LD07717 LD09287 LD10972 LD11387 LD11603 LD11764 LD12423 LD16442 LD17642 LD18666 LD20060 LD33167 LD44211 LD44395 LD47342 LP02772 LP23410 RE03754 RE04308 RE06345 RE08803 RE11874 RE14172 RE14349 RE15232 RE15289 RE15970 RE16401 RE18488 RE25811 RE27045 RE28268 RE29352 RE31389 RE31635 RE32048 RE32244 RE43015 RE44472 RE48851 RE48875 RE50751 RE50775 RE53890 RE54755 RE54820 RE60259 RE64878 RE64959 RE68406 RE73634 RE74638 RH12241 RH21766 RH30350 RH35152 RH50892 RH57121 RH57831 RH64489 SD12823 SD15379 SD19714
Other clones	237 9196 9580 10531 15410 19495 27982 28303 28829 29461 29917 31732 33165 37523 43755 47047 54552 55770 57274 62517 63701 65035 65219 70350 71004 76361 77289 78481 79103 97344 98386 100510 101334 103456 105175 118246 120134 121168 121396 124654 125075 147387 158608 160285 163360 164734 174858 175627 177335 191109 214219.9 214221.14 214225.11 214275.18 214281.13 214289.13 214311.12 214313.13 214353.16 214413.11 214435.10 214449.13 214545.11 273539 274576 280303 280360 283178 524646 527286 bs17h02 CK01.7B.A4 CK01.15C.E7 CK01.21A.F6 CK01.24B.E1 CK01.42B.B1 CK01.65A.E1 CK01.65C.H3 CK01.75D.C11 CK01.77A.E8 CK01.77B.D10 CK01.77B.F11 CK01.85C.C8 CK01.86C.G12 CK01.91C.D4 CK01.96A.C3 CK01.101D.D10 CK01.101D.H11 CK01.109B.G10 CK01.109D.C12 CK01.112C.G6 CK01.127C.B10 CK01.167A.E3 Dmel_dig_017406_0662_1798 Dmel_neb_004253_0881_0329 Dmel_neb_005062_0701_1030 Dmel_neb_011613_0638_3331 Dmel_neb_012465_0702_1497 Dmel_neb_013060_0828_3452 Dmel_neb_013365_0958_0909 Dmel_neb_013684_0819_3574 Dmel_neb_013783_0684_1342 Dmel_neb_013937_0853_1837 EC055457 EK009609 EK015620 EK050837 EK053017 EK053330 EK059212 EK060252 EK060422 EK060445 EK067744 EK068260 EK071646 EK071804 EK071808 EK074610 EK075761 EK085930 EK085945 EK097829 EK099044 EK100144 EK102118 EK105563 EK106124 EK107863 EK108463 EK110642 EK133362 EK135713 EK135916 EK137926 EK141457 EK144706 EK150022 EK159406 EK160337 EK165050 EK177419 EK179817 EK183913 EK188235 EK190949 EK197738 EK198843 EK207950 EK210659 EK221034 EK223162 EK230549 EK240046 EK241417 EK241452 EK242246 EK243554 EK247058 EK247254 EK249934 EK251513 EK261564 EK263126 EK276011 EK290428 EK290614 EK291654 EK294040 EK302019 EK305121 EK305210 EK308201 EK308636 EN03608 EN05623 EN07629 EN08105 EP00148 EP01038 EP04034 EP07433 EP08741 EP11352 EP11733 EP12133 EP13420 EP13522 EP15805 EP21913 FGH124E09 FGM234G07 GH12226 LP11902 RC0-DA0001-120700-021-F04 RC0-DA0001-120700-023-B11 RC0-DA0001-120700-028-B02 RC0-DA0001-120700-029-D08 RC0-DA0001-120700-029-F06 RC0-DA0001-130700-212-F09 RC0-DA0001-130700-212-G02 RP003102880 RP003224662
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015024 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32221
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CkIα CG2028 (Ke, 1999.11)
Source for database merge of	Source for merge of: CkIα anon-WO03040301.93 anon-WO03040301.95 (FlyBase, 1996-) Source for merge of: CkIα l(1)G0492 (Peter et al., 2002)
Additional comments	Source for merge of CkIα anon-WO03040301.93 anon-WO03040301.95 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against CkIα profoundly increases the wg-signaling pathway. (Seto and Bellen, 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) The dco and CkIα products act additively to provide optimal kinase activity required for efficient ci protein phosphorylation and processing. (Jia et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells and a a decrease in cell size is seen. (Bettencourt-Dias et al., 2004) CkIα phosphorylates arm and may stimulate its degradation. (Yanagawa et al., 2002) CkIα protein is isolated and characterised. (Santos et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078585 NM_167331 NM_167332 NM_001169266 RefSeq (Proteins) • NP_511140 NP_727631 NP_727632 NP_001162737 DDBJ / EMBL / GenBank • AA246663 AAB16904 AAF48192 AAF48193 AAL39491 AAN09313 ACZ95272 AI512357 AI945875 AJ426882 AQ025495 AW942057 AX777239 AX777241 AY069346 CAA64358 CZ472330 U55848 X94695 Entrez Gene - A searchable database of RefSeq genes. • 32221 UniProtKB/Swiss-Prot • P54367
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58615 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015024 DroID - A comprehensive database of gene and protein interactions. • FBgn0015024 DRSC - Results from RNAi screens. • FBgn0015024 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015024 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2028-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015024 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 93695 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32221 InParanoid A subset of ortholog calls from InParanoid. • AAEL007662-PA Aedes aegypti (mosquito) AGAP000627-PA Anopheles gambiae (mosquito) XP_393612.2 Apis mellifera (honey bee) 107521 Branchiostoma floridae (lancelet) BGIBMGA014220-PA Bombyx mori (silk worm) ENSBTAP00000040522 Bos taurus (bovine) CN17884 Caenorhabditis brenneri (small nematode) CBP04738 Caenorhabditis briggsae (nematode) CE00872 Caenorhabditis elegans (worm) ENSCINP00000016371 Ciona intestinalis (sea squirt) JA09517 Caenorhabditis japonica (nematode) CPIJ017578 Culex pipens (mosquito) CPIJ017982 Culex pipens (mosquito) ENSCPOP00000000957 Cavia porcellus (guinea pig) RP23783 Caenorhabditis remanei (nematode) ENSCSAVP00000001596 Ciona savignyi (sedentary tunicate) 20777 Capitella spl (polychaete worm) 301140 Daphnia pulex (daphnia) ENSDARP00000027892 Danio rerio (zebra fish) ENSDARP00000069059 Danio rerio (zebra fish) ENSECAP00000003397 Equus caballus (horse) ENSGACP00000025886 Gymnopilus aculeatus (mushroom) ENSGALP00000002080 Gallus gallus (chicken) GL50803_7537 Giardia lamblia (flagellated protozoan) 186278 Hypsipyla robusta (cedar shoot borer) ENSP00000261798 Homo sapiens (human) ISCW001795-PA Ixodes scapularis (deer tick) 204147 Lottia gigantea (owl limpet) ENSMODP00000038028 Monodelphis domestica (gray opossum) ENSMMUP00000033886 Macaca mulatta (rhesus monkey) ENSMUSP00000110901 Mus musculus (house mouse) 161273 Nematostella vectensis (starlet anemone) XP_001607697.1 Nasonia vitripennis (wasp) ENSORLP00000025560 Oryzias latipes (japanese killifish) PHUM000065-PA Pediculus humanus (human body louse) PP24697 Pristionchus pacificus (nematode) ENSPPYP00000006028 Pongo pygmaeus (orangutan) ENSPTRP00000047919 Pan troglodytes (chimpanzee) ENSRNOP00000051516 Rattus norvegicus (norway rat) Smp_067810 Schistosoma mansoni (trematode parasite) XP_786391.1 Strongylocentrotus purpuratus (purple sea urchin) 50603 Trichoplax adhaerens (metazoa) XP_973313.2 Tribolium castaneum (red flour beetle) ENSTRUP00000000684 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000045038 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32221 modMine - Data generated by the modENCODE project. • FBgn0015024 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10764 LH18256 ISCW007936 ISCW001795 FBgn0234510 FBgn0227476 FBgn0203103 FBgn0166522 JGI_V11_301140 FBgn0075218 FBgn0150746 FBgn0138974 FBgn0120074 FBgn0109956 FBgn0098385 CPIJ017578 CPIJ017982 BGIBMGA014220 GB10720 AGAP000627 AAEL007662 PB25361 PHUM456320 GLEAN_12576
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	anon-WO03040301.93   anon-WO03040301.95   CG2028 (Morrison et al., 2000, Perkins et al., 1.15.2009, Buechling et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CK1 (Kalderon, 2005, Lum and Beachy, 2004, Ou et al., 2003, Nybakken and Perrimon, 2002, Wharton, 2003, Price et al., 2003, Lefers and Holmgren, 2002, Smelkinson and Kalderon, 2006, Smelkinson and Kalderon, 2006, Tolwinski, 2007, Torroja et al., 2005, Zhao et al., 2007, Smelkinson et al., 2007, Jia et al., 2009) CK1a (Zhang et al., 2005) ck1a (Seto and Bellen, 2006) CK1alpha (Ding and Dale, 2002, Kalderon, 2002) CK1α (Bjorklund et al., 2006, Fearon and Cadigan, 2005, Lum et al., 2003, Mennella et al., 2009, Buechling et al., 2010) ck1α (DasGupta et al., 2005) CKI (Bienz and Hamada, 2004, Jiang, 2002, Ishii, 2005, Heeg-Truesdell, 2006, Stadeli, 2006, Price et al., 2007, Tountas and Fortini, 2007) CK I (Behrens, 2000, Horiuchi et al., 2000, Weber et al., 2007) CkIa (Peter et al., 2002, Pospisilik et al., 2010) CKIa (Morrison et al., 2000) CkIalpha (Giot et al., 2003, Popodi et al., 2010-, Wasbrough et al., 2010) CKIalpha (Blanco et al., 2010) CKIα (Jia et al., 2004, Bussell, 2003, Polakis, 2002, Yanagawa et al., 2002, Strutt et al., 2006, Jia et al., 2005, Zhang et al., 2006, Matsubayashi et al., 2004, Feng and Irvine, 2009, D'Ambrosio and Vale, 2010) CkIα (Furlong, 2005, Stroschein-Stevenson et al., 2006, Nybakken et al., 2005, Liu et al., 2007, Zhang et al., 2005, Bai et al., 2007) CKI α (Takada et al., 2005) dmCK1 (Santos et al., 1996) dmckI (Santos, 1996.1.4, ) l(1)G0492 (Schaefer et al., 1999.12.14, ) PKA-C (Matsubayashi et al., 2004)
Name Synonym	caesin kinase I α (D'Ambrosio and Vale, 2010) Casein Kinase 1 (Apionishev et al., 2005, Stadeli, 2006, Torroja et al., 2005) Casein kinase 1 (Santos et al., 1996) casein kinase 1 (Smelkinson and Kalderon, 2006) casein kinase 1a (Seto and Bellen, 2006) casein kinase I (Bienz and Hamada, 2004) Casein kinase I (Tountas and Fortini, 2007, Marques, 2005) Casein kinase Iα (Edwards et al., 2009, Cadigan, 2002) casein kinase Iα (Matsubayashi et al., 2004)
Secondary FlyBase IDs
	FBgn0029043 FBgn0066807 FBgn0066808
References ( 94 )
Generate a list of	All references relating to this gene ( 94 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 7 ) Review  ( 23 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 7 ) FlyBase analysis  ( 3 ) Conference report  ( 4 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 4 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Buechling et al., 2010, Curr. Biol. 20(14): 1263--1268 Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor. [FBrf0211368] D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...