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Gene Dmel\cype

General Information
Symbol	Dmel\cype	Species	D. melanogaster
Name	cyclope	Annotation symbol	CG14028
Feature type	protein_coding_gene	FlyBase ID	FBgn0015031
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	l(2)03771, cyc
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25D6-25D6	Sequence location	2L:5,327,241..5,327,969 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cyclope is referred to in FlyBase by the symbol Dmel\cype (CG14028, FBgn0015031). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cytochrome-c oxidase activity. Based on sequence similarity, it is predicted to be involved in the biological process: mitochondrial electron transport, cytochrome c to oxygen. 19 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; adult; multicellular structure; external compound sense organ; thoracic segment; acellular anatomical structure; sense organ; region of integument. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Cytochrome c oxidase subunit VIc. Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638416_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cype. Gene sequence location is 2L:5327241..5327969.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25D6-25D6   Limits computationally determined from genome sequence between P{lacW}vrik05901&P{PZ}cype03771 and P{lacW}Hel25Ek11511
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25D4-25D6     (Terracol, 2001.4.6) 25D4-25D6   (determined by in situ hybridisation)   (Spradling et al., 1999) 25D4-25D6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cype for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cype-RA FBtr0079072  NM_080526   382   77 cype-RB FBtr0307034  NM_001258956   398   77 cype-RC FBtr0307035  NM_001258957   446   77
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cype-PA   FBpp0078707   8.3   77   10.46     NP_536787   AAF52241 cype-PB   FBpp0297877   8.3   77   10.46     NP_001245885   AFH03560 cype-PC   FBpp0297878   8.3   77   10.46     NP_001245886   AFH03561
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome c oxidase subunit VIc (IPR004204) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME14028
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52241   AE014134 AFH03560   AE014134 AFH03561   AI296358   AQ025616   AY029256 AAK32965   AY118737 AAM50597   BG632172   BI374139   BI569463   BI614803   BI619172   BP548713   BP552715   BQ102825   CO181813   CO286007   CO286010   CO290087   CO292622   CO296969   CO311572   CZ479361   CZ479362   CZ479363   CZ489371   EC072500   EC081293   EC085847   EC087056   EC087893   EC090989   EC207363   EC213150   EC219097   EC219140   EC225275   EC234829   EC235601   EV577395   EV578313   EV582184   EV593900
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMS1 Q8MSK4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuroblast   (Szuplewski and Terracol, 2001) embryonic stage 1 -- 3   organism | ubiquitous   (Szuplewski and Terracol, 2001) Comment:maternally contributed embryonic stage 10   organism | segmentally repeated   (Szuplewski and Terracol, 2001) embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   (Szuplewski and Terracol, 2001) oogenesis stage S10 & adult stage | female   follicle cell   (Szuplewski and Terracol, 2001) adult stage | female & oogenesis stage S10   oocyte   (Szuplewski and Terracol, 2001) Comment:expression stronger thanin follicle cell northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Szuplewski and Terracol, 2001) Comment:transcripts are more abundant in adult males
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1721.275 Larval Midgut    3272.7 Larval Hindgut    3119.3 Larval Malpighian Tubules    2915.3 Larval Fat Body    1049.4 Larval Salivary Gland    2692.9 Larval Trachea    1886.875 Larval Carcass    3510.65 Adult Head    2886 Adult Eye    2972.2 Adult Brain    2169.5 Adult Thoracic-Abdominal Ganglion    2996.4 Adult Crop    3431.4 Adult Midgut    2819.5 Adult Hindgut    3581.2 Adult Malpighian Tubules    3624.9 Adult Fat Body    3604 Adult Salivary Gland    5143.2 Adult Heart    3984.65 Adult VirginFemale Spermatheca    4700.9 Adult InseminatedFemale Spermatheca    4329.8 Adult Ovary    1289 Adult Testis    507.2 Adult Male Accessory Gland    1859.9 Adult Carcass    4370.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1721.275) Larval Midgut  (3272.7) Larval Hindgut  (3119.3) Larval Malpighian Tubules  (2915.3) Larval Fat Body  (1049.4) Larval Salivary Gland  (2692.9) Larval Trachea  (1886.875) Larval Carcass  (3510.65) Adult Head  (2886) Adult Eye  (2972.2) Adult Brain  (2169.5) Adult Thoracic-Abdominal Ganglion  (2996.4) Adult Crop  (3431.4) Adult Midgut  (2819.5) Adult Hindgut  (3581.2) Adult Malpighian Tubules  (3624.9) Adult Fat Body  (3604) Adult Salivary Gland  (5143.2) Adult Heart  (3984.65) Adult VirginFemale Spermatheca  (4700.9) Adult InseminatedFemale Spermatheca  (4329.8) Adult Ovary  (1289) Adult Testis  507.2 Adult Male Accessory Gland  (1859.9) Adult Carcass  (4370.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1721.275) Larval Midgut  (3272.7) Larval Hindgut  (3119.3) Larval Malpighian Tubules  (2915.3) Larval Fat Body  1049.4 Larval Salivary Gland  (2692.9) Larval Trachea  (1886.875) Larval Carcass  (3510.65) Adult Head  (2886) Adult Eye  (2972.2) Adult Brain  (2169.5) Adult Thoracic-Abdominal Ganglion  (2996.4) Adult Crop  (3431.4) Adult Midgut  (2819.5) Adult Hindgut  (3581.2) Adult Malpighian Tubules  (3624.9) Adult Fat Body  (3604) Adult Salivary Gland  (5143.2) Adult Heart  (3984.65) Adult VirginFemale Spermatheca  (4700.9) Adult InseminatedFemale Spermatheca  (4329.8) Adult Ovary  (1289) Adult Testis    507.2 Adult Male Accessory Gland  (1859.9) Adult Carcass  (4370.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1721.275 Larval Midgut    3272.7 Larval Hindgut    3119.3 Larval Malpighian Tubules    2915.3 Larval Fat Body    1049.4 Larval Salivary Gland    2692.9 Larval Trachea    1886.875 Larval Carcass    3510.65 Adult Head    2886 Adult Eye    2972.2 Adult Brain    2169.5 Adult Thoracic-Abdominal Ganglion    2996.4 Adult Crop    3431.4 Adult Midgut    2819.5 Adult Hindgut    3581.2 Adult Malpighian Tubules    3624.9 Adult Fat Body    3604 Adult Salivary Gland    5143.2 Adult Heart    3984.65 Adult VirginFemale Spermatheca    4700.9 Adult InseminatedFemale Spermatheca    4329.8 Adult Ovary    1289 Adult Testis    507.2 Adult Male Accessory Gland    1859.9 Adult Carcass    4370.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1721.275 Larval Midgut    3272.7 Larval Hindgut    3119.3 Larval Malpighian Tubules    2915.3 Larval Fat Body    1049.4 Larval Salivary Gland    2692.9 Larval Trachea    1886.875 Larval Carcass    3510.65 Adult Head    2886 Adult Eye    2972.2 Adult Brain    2169.5 Adult Thoracic-Abdominal Ganglion    2996.4 Adult Crop    3431.4 Adult Midgut    2819.5 Adult Hindgut    3581.2 Adult Malpighian Tubules    3624.9 Adult Fat Body    3604 Adult Salivary Gland    5143.2 Adult Heart    3984.65 Adult VirginFemale Spermatheca    4700.9 Adult InseminatedFemale Spermatheca    4329.8 Adult Ovary    1289 Adult Testis    507.2 Adult Male Accessory Gland    1859.9 Adult Carcass    4370.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1721.275) Larval Midgut  (3272.7) Larval Hindgut  (3119.3) Larval Malpighian Tubules  (2915.3) Larval Fat Body  (1049.4) Larval Salivary Gland  (2692.9) Larval Trachea  (1886.875) Larval Carcass  (3510.65) Adult Head  (2886) Adult Eye  (2972.2) Adult Brain  (2169.5) Adult Thoracic-Abdominal Ganglion  (2996.4) Adult Crop  (3431.4) Adult Midgut  (2819.5) Adult Hindgut  (3581.2) Adult Malpighian Tubules  (3624.9) Adult Fat Body  (3604) Adult Salivary Gland  (5143.2) Adult Heart  (3984.65) Adult VirginFemale Spermatheca  (4700.9) Adult InseminatedFemale Spermatheca  (4329.8) Adult Ovary  (1289) Adult Testis  507.2 Adult Male Accessory Gland  (1859.9) Adult Carcass  (4370.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1721.275) Larval Midgut  (3272.7) Larval Hindgut  (3119.3) Larval Malpighian Tubules  (2915.3) Larval Fat Body  1049.4 Larval Salivary Gland  (2692.9) Larval Trachea  (1886.875) Larval Carcass  (3510.65) Adult Head  (2886) Adult Eye  (2972.2) Adult Brain  (2169.5) Adult Thoracic-Abdominal Ganglion  (2996.4) Adult Crop  (3431.4) Adult Midgut  (2819.5) Adult Hindgut  (3581.2) Adult Malpighian Tubules  (3624.9) Adult Fat Body  (3604) Adult Salivary Gland  (5143.2) Adult Heart  (3984.65) Adult VirginFemale Spermatheca  (4700.9) Adult InseminatedFemale Spermatheca  (4329.8) Adult Ovary  1289 Adult Testis    507.2 Adult Male Accessory Gland  (1859.9) Adult Carcass  (4370.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1721.275 Larval Midgut    3272.7 Larval Hindgut    3119.3 Larval Malpighian Tubules    2915.3 Larval Fat Body    1049.4 Larval Salivary Gland    2692.9 Larval Trachea    1886.875 Larval Carcass    3510.65 Adult Head    2886 Adult Eye    2972.2 Adult Brain    2169.5 Adult Thoracic-Abdominal Ganglion    2996.4 Adult Crop    3431.4 Adult Midgut    2819.5 Adult Hindgut    3581.2 Adult Malpighian Tubules    3624.9 Adult Fat Body    3604 Adult Salivary Gland    5143.2 Adult Heart    3984.65 Adult VirginFemale Spermatheca    4700.9 Adult InseminatedFemale Spermatheca    4329.8 Adult Ovary    1289 Adult Testis    507.2 Adult Male Accessory Gland    1859.9 Adult Carcass    4370.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2886   NA  Eye    2972.2   NA  Brain    2169.5   1721.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2996.4   NA  Crop    3431.4   3272.7  Midgut    2819.5   3119.3  Hindgut    3581.2   2915.3  Malpighian Tubules    3624.9   1049.4  Fat Body    3604   2692.9  Salivary Gland    5143.2   NA  Heart    3984.65   1886.875  Trachea    NA   NA  VirginFemale Spermatheca    4700.9   NA  InseminatedFemale Spermatheca    4329.8   NA  Ovary    1289   NA  Testis    507.2   NA  Male Accessory Gland    1859.9   3510.65  Carcass    4370.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    249 central nervous system, larvae L3    177 central nervous system, pupae P8    203 head, virgin 1-day female    560 head, virgin 4-day female    370 head, virgin 20-day female    206 head, mated 1-day female    451 head, mated 4-day female    211 head, mated 20-day female    213 head, mated 1-day male    703 head, mated 4-day male    349 head, mated 20-day male    374 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    84 digestive system, larvae L3 wandering    190 digestive system, 1-day adult    441 digestive system, 4-day adult    296 digestive system, 20-day adult    321 fat body, larvae L3 wandering    109 fat body, white prepupae    50 fat body, pupae P8    226 carcass, larvae L3 wandering    173 carcass, 1-day adult    1009 carcass, 4-day adult    516 carcass, 20-day adult    492 ovary, virgin 4-day female    152 ovary, mated 4-day female    179 testis, mated 4-day male    162 accessory gland, mated 4-day male    231 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (249) central nervous system, larvae L3  (177) central nervous system, pupae P8  (203) head, virgin 1-day female  (560) head, virgin 4-day female  (370) head, virgin 20-day female  (206) head, mated 1-day female  (451) head, mated 4-day female  (211) head, mated 20-day female  (213) head, mated 1-day male  (703) head, mated 4-day male  (349) head, mated 20-day male  (374) salivary gland, larvae L3 wandering  (60) salivary gland, white prepupae  (84) digestive system, larvae L3 wandering  (190) digestive system, 1-day adult  (441) digestive system, 4-day adult  (296) digestive system, 20-day adult  (321) fat body, larvae L3 wandering  (109) fat body, white prepupae  (50) fat body, pupae P8  (226) carcass, larvae L3 wandering  (173) carcass, 1-day adult  (1009) carcass, 4-day adult  (516) carcass, 20-day adult  (492) ovary, virgin 4-day female  (152) ovary, mated 4-day female  (179) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (231) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (249) central nervous system, larvae L3  (177) central nervous system, pupae P8  (203) head, virgin 1-day female  (560) head, virgin 4-day female  (370) head, virgin 20-day female  (206) head, mated 1-day female  (451) head, mated 4-day female  (211) head, mated 20-day female  (213) head, mated 1-day male  (703) head, mated 4-day male  (349) head, mated 20-day male  (374) salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    84 digestive system, larvae L3 wandering  (190) digestive system, 1-day adult  (441) digestive system, 4-day adult  (296) digestive system, 20-day adult  (321) fat body, larvae L3 wandering  (109) fat body, white prepupae    50 fat body, pupae P8  (226) carcass, larvae L3 wandering  (173) carcass, 1-day adult  (1009) carcass, 4-day adult  (516) carcass, 20-day adult  (492) ovary, virgin 4-day female  (152) ovary, mated 4-day female  (179) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (231) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    249 central nervous system, larvae L3    177 central nervous system, pupae P8    203 head, virgin 1-day female    560 head, virgin 4-day female    370 head, virgin 20-day female    206 head, mated 1-day female    451 head, mated 4-day female    211 head, mated 20-day female    213 head, mated 1-day male    703 head, mated 4-day male    349 head, mated 20-day male    374 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    84 digestive system, larvae L3 wandering    190 digestive system, 1-day adult    441 digestive system, 4-day adult    296 digestive system, 20-day adult    321 fat body, larvae L3 wandering    109 fat body, white prepupae    50 fat body, pupae P8    226 carcass, larvae L3 wandering    173 carcass, 1-day adult    1009 carcass, 4-day adult    516 carcass, 20-day adult    492 ovary, virgin 4-day female    152 ovary, mated 4-day female    179 testis, mated 4-day male    162 accessory gland, mated 4-day male    231 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    249 central nervous system, larvae L3    177 central nervous system, pupae P8    203 head, virgin 1-day female    560 head, virgin 4-day female    370 head, virgin 20-day female    206 head, mated 1-day female    451 head, mated 4-day female    211 head, mated 20-day female    213 head, mated 1-day male    703 head, mated 4-day male    349 head, mated 20-day male    374 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    84 digestive system, larvae L3 wandering    190 digestive system, 1-day adult    441 digestive system, 4-day adult    296 digestive system, 20-day adult    321 fat body, larvae L3 wandering    109 fat body, white prepupae    50 fat body, pupae P8    226 carcass, larvae L3 wandering    173 carcass, 1-day adult    1009 carcass, 4-day adult    516 carcass, 20-day adult    492 ovary, virgin 4-day female    152 ovary, mated 4-day female    179 testis, mated 4-day male    162 accessory gland, mated 4-day male    231 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (249) central nervous system, larvae L3  (177) central nervous system, pupae P8  (203) head, virgin 1-day female  (560) head, virgin 4-day female  (370) head, virgin 20-day female  (206) head, mated 1-day female  (451) head, mated 4-day female  (211) head, mated 20-day female  (213) head, mated 1-day male  (703) head, mated 4-day male  (349) head, mated 20-day male  (374) salivary gland, larvae L3 wandering  (60) salivary gland, white prepupae  (84) digestive system, larvae L3 wandering  (190) digestive system, 1-day adult  (441) digestive system, 4-day adult  (296) digestive system, 20-day adult  (321) fat body, larvae L3 wandering  (109) fat body, white prepupae  (50) fat body, pupae P8  (226) carcass, larvae L3 wandering  (173) carcass, 1-day adult  (1009) carcass, 4-day adult  (516) carcass, 20-day adult  (492) ovary, virgin 4-day female  (152) ovary, mated 4-day female  (179) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (231) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (249) central nervous system, larvae L3  (177) central nervous system, pupae P8  (203) head, virgin 1-day female  (560) head, virgin 4-day female  (370) head, virgin 20-day female  (206) head, mated 1-day female  (451) head, mated 4-day female  (211) head, mated 20-day female  (213) head, mated 1-day male  (703) head, mated 4-day male  (349) head, mated 20-day male  (374) salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    84 digestive system, larvae L3 wandering  (190) digestive system, 1-day adult  (441) digestive system, 4-day adult  (296) digestive system, 20-day adult  (321) fat body, larvae L3 wandering  109 fat body, white prepupae    50 fat body, pupae P8  (226) carcass, larvae L3 wandering  (173) carcass, 1-day adult  (1009) carcass, 4-day adult  (516) carcass, 20-day adult  (492) ovary, virgin 4-day female  (152) ovary, mated 4-day female  (179) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (231) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    249 central nervous system, larvae L3    177 central nervous system, pupae P8    203 head, virgin 1-day female    560 head, virgin 4-day female    370 head, virgin 20-day female    206 head, mated 1-day female    451 head, mated 4-day female    211 head, mated 20-day female    213 head, mated 1-day male    703 head, mated 4-day male    349 head, mated 20-day male    374 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    84 digestive system, larvae L3 wandering    190 digestive system, 1-day adult    441 digestive system, 4-day adult    296 digestive system, 20-day adult    321 fat body, larvae L3 wandering    109 fat body, white prepupae    50 fat body, pupae P8    226 carcass, larvae L3 wandering    173 carcass, 1-day adult    1009 carcass, 4-day adult    516 carcass, 20-day adult    492 ovary, virgin 4-day female    152 ovary, mated 4-day female    179 testis, mated 4-day male    162 accessory gland, mated 4-day male    231 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    199 embryo 02-04hr    303 embryo 04-06hr    363 embryo 06-08hr    310 embryo 08-10hr    255 embryo 10-12hr    285 embryo 12-14hr    235 embryo 14-16hr    316 embryo 16-18hr    374 embryo 18-20hr    442 embryo 20-22hr    501 embryo 22-24hr    501 larva L1    643 larva L2    597 larva L3 12hr old    566 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    191 larva L3 puffstage 7-9    174 white prepupae new    143 white prepupae 12hr    125 white prepupae 24hr    121 pupae 2d postWPP    222 pupae 3d postWPP    514 pupae 4d postWPP    816 adult male 01day    803 adult male 05day    720 adult male 30day    351 adult female 01day    685 adult female 05day    322 adult female 30day    269 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (199) embryo 02-04hr  (303) embryo 04-06hr  (363) embryo 06-08hr  (310) embryo 08-10hr  (255) embryo 10-12hr  (285) embryo 12-14hr  (235) embryo 14-16hr  (316) embryo 16-18hr  (374) embryo 18-20hr  (442) embryo 20-22hr  (501) embryo 22-24hr  (501) larva L1  (643) larva L2  (597) larva L3 12hr old  (566) larva L3 puffstage 1-2  (367) larva L3 puffstage 3-6  (191) larva L3 puffstage 7-9  (174) white prepupae new  (143) white prepupae 12hr  (125) white prepupae 24hr  (121) pupae 2d postWPP  (222) pupae 3d postWPP  (514) pupae 4d postWPP  (816) adult male 01day  (803) adult male 05day  (720) adult male 30day  (351) adult female 01day  (685) adult female 05day  (322) adult female 30day  (269) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (199) embryo 02-04hr  (303) embryo 04-06hr  (363) embryo 06-08hr  (310) embryo 08-10hr  (255) embryo 10-12hr  (285) embryo 12-14hr  (235) embryo 14-16hr  (316) embryo 16-18hr  (374) embryo 18-20hr  (442) embryo 20-22hr  (501) embryo 22-24hr  (501) larva L1  (643) larva L2  (597) larva L3 12hr old  (566) larva L3 puffstage 1-2  (367) larva L3 puffstage 3-6  (191) larva L3 puffstage 7-9  (174) white prepupae new  (143) white prepupae 12hr  (125) white prepupae 24hr  (121) pupae 2d postWPP  (222) pupae 3d postWPP  (514) pupae 4d postWPP  (816) adult male 01day  (803) adult male 05day  (720) adult male 30day  (351) adult female 01day  (685) adult female 05day  (322) adult female 30day  (269) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    199 embryo 02-04hr    303 embryo 04-06hr    363 embryo 06-08hr    310 embryo 08-10hr    255 embryo 10-12hr    285 embryo 12-14hr    235 embryo 14-16hr    316 embryo 16-18hr    374 embryo 18-20hr    442 embryo 20-22hr    501 embryo 22-24hr    501 larva L1    643 larva L2    597 larva L3 12hr old    566 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    191 larva L3 puffstage 7-9    174 white prepupae new    143 white prepupae 12hr    125 white prepupae 24hr    121 pupae 2d postWPP    222 pupae 3d postWPP    514 pupae 4d postWPP    816 adult male 01day    803 adult male 05day    720 adult male 30day    351 adult female 01day    685 adult female 05day    322 adult female 30day    269 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    199 embryo 02-04hr    303 embryo 04-06hr    363 embryo 06-08hr    310 embryo 08-10hr    255 embryo 10-12hr    285 embryo 12-14hr    235 embryo 14-16hr    316 embryo 16-18hr    374 embryo 18-20hr    442 embryo 20-22hr    501 embryo 22-24hr    501 larva L1    643 larva L2    597 larva L3 12hr old    566 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    191 larva L3 puffstage 7-9    174 white prepupae new    143 white prepupae 12hr    125 white prepupae 24hr    121 pupae 2d postWPP    222 pupae 3d postWPP    514 pupae 4d postWPP    816 adult male 01day    803 adult male 05day    720 adult male 30day    351 adult female 01day    685 adult female 05day    322 adult female 30day    269 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (199) embryo 02-04hr  (303) embryo 04-06hr  (363) embryo 06-08hr  (310) embryo 08-10hr  (255) embryo 10-12hr  (285) embryo 12-14hr  (235) embryo 14-16hr  (316) embryo 16-18hr  (374) embryo 18-20hr  (442) embryo 20-22hr  (501) embryo 22-24hr  (501) larva L1  (643) larva L2  (597) larva L3 12hr old  (566) larva L3 puffstage 1-2  (367) larva L3 puffstage 3-6  (191) larva L3 puffstage 7-9  (174) white prepupae new  (143) white prepupae 12hr  (125) white prepupae 24hr  (121) pupae 2d postWPP  (222) pupae 3d postWPP  (514) pupae 4d postWPP  (816) adult male 01day  (803) adult male 05day  (720) adult male 30day  (351) adult female 01day  (685) adult female 05day  (322) adult female 30day  (269) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (199) embryo 02-04hr  (303) embryo 04-06hr  (363) embryo 06-08hr  (310) embryo 08-10hr  (255) embryo 10-12hr  (285) embryo 12-14hr  (235) embryo 14-16hr  (316) embryo 16-18hr  (374) embryo 18-20hr  (442) embryo 20-22hr  (501) embryo 22-24hr  (501) larva L1  (643) larva L2  (597) larva L3 12hr old  (566) larva L3 puffstage 1-2  (367) larva L3 puffstage 3-6  (191) larva L3 puffstage 7-9  (174) white prepupae new  143 white prepupae 12hr  125 white prepupae 24hr  121 pupae 2d postWPP  (222) pupae 3d postWPP  (514) pupae 4d postWPP  (816) adult male 01day  (803) adult male 05day  (720) adult male 30day  (351) adult female 01day  (685) adult female 05day  (322) adult female 30day  (269) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    199 embryo 02-04hr    303 embryo 04-06hr    363 embryo 06-08hr    310 embryo 08-10hr    255 embryo 10-12hr    285 embryo 12-14hr    235 embryo 14-16hr    316 embryo 16-18hr    374 embryo 18-20hr    442 embryo 20-22hr    501 embryo 22-24hr    501 larva L1    643 larva L2    597 larva L3 12hr old    566 larva L3 puffstage 1-2    367 larva L3 puffstage 3-6    191 larva L3 puffstage 7-9    174 white prepupae new    143 white prepupae 12hr    125 white prepupae 24hr    121 pupae 2d postWPP    222 pupae 3d postWPP    514 pupae 4d postWPP    816 adult male 01day    803 adult male 05day    720 adult male 30day    351 adult female 01day    685 adult female 05day    322 adult female 30day    269 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    395 Schneider line 2 Sg4    208 embryonic 1182-4H    188 embryonic GM2    92 embryonic Kc167    64 embryonic S1    525 embryonic S3    225 leg disc CME L1    246 wing disc CME-W2    254 wing disc ML-DmD8    185 wing disc ML-DmD9    380 wing disc ML-DmD16-c3    135 wing disc ML-DmD21    419 wing disc ML-DmD32    350 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    839 antennal disc ML-DmD20-c5    318 mixed discs ML-DmD4-c1    213 CNS ML-DmBG1-c1    374 CNS ML-DmBG2-c2    154 tumorous blood cells mbn2    153 ovary fGS/OSS    119 ovary OSC    175 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (395) Schneider line 2 Sg4  (208) embryonic 1182-4H  (188) embryonic GM2  (92) embryonic Kc167  (64) embryonic S1  (525) embryonic S3  (225) leg disc CME L1  (246) wing disc CME-W2  (254) wing disc ML-DmD8  (185) wing disc ML-DmD9  (380) wing disc ML-DmD16-c3  (135) wing disc ML-DmD21  (419) wing disc ML-DmD32  (350) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (839) antennal disc ML-DmD20-c5  (318) mixed discs ML-DmD4-c1  (213) CNS ML-DmBG1-c1  (374) CNS ML-DmBG2-c2  (154) tumorous blood cells mbn2  (153) ovary fGS/OSS  (119) ovary OSC  (175) ovary OSS  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (395) Schneider line 2 Sg4  (208) embryonic 1182-4H  (188) embryonic GM2    92 embryonic Kc167    64 embryonic S1  (525) embryonic S3  (225) leg disc CME L1  (246) wing disc CME-W2  (254) wing disc ML-DmD8  (185) wing disc ML-DmD9  (380) wing disc ML-DmD16-c3  (135) wing disc ML-DmD21  (419) wing disc ML-DmD32  (350) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (839) antennal disc ML-DmD20-c5  (318) mixed discs ML-DmD4-c1  (213) CNS ML-DmBG1-c1  (374) CNS ML-DmBG2-c2  (154) tumorous blood cells mbn2  (153) ovary fGS/OSS  (119) ovary OSC  (175) ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    395 Schneider line 2 Sg4    208 embryonic 1182-4H    188 embryonic GM2    92 embryonic Kc167    64 embryonic S1    525 embryonic S3    225 leg disc CME L1    246 wing disc CME-W2    254 wing disc ML-DmD8    185 wing disc ML-DmD9    380 wing disc ML-DmD16-c3    135 wing disc ML-DmD21    419 wing disc ML-DmD32    350 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    839 antennal disc ML-DmD20-c5    318 mixed discs ML-DmD4-c1    213 CNS ML-DmBG1-c1    374 CNS ML-DmBG2-c2    154 tumorous blood cells mbn2    153 ovary fGS/OSS    119 ovary OSC    175 ovary OSS    49 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    395 Schneider line 2 Sg4    208 embryonic 1182-4H    188 embryonic GM2    92 embryonic Kc167    64 embryonic S1    525 embryonic S3    225 leg disc CME L1    246 wing disc CME-W2    254 wing disc ML-DmD8    185 wing disc ML-DmD9    380 wing disc ML-DmD16-c3    135 wing disc ML-DmD21    419 wing disc ML-DmD32    350 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    839 antennal disc ML-DmD20-c5    318 mixed discs ML-DmD4-c1    213 CNS ML-DmBG1-c1    374 CNS ML-DmBG2-c2    154 tumorous blood cells mbn2    153 ovary fGS/OSS    119 ovary OSC    175 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (395) Schneider line 2 Sg4  (208) embryonic 1182-4H  (188) embryonic GM2  (92) embryonic Kc167  (64) embryonic S1  (525) embryonic S3  (225) leg disc CME L1  (246) wing disc CME-W2  (254) wing disc ML-DmD8  (185) wing disc ML-DmD9  (380) wing disc ML-DmD16-c3  (135) wing disc ML-DmD21  (419) wing disc ML-DmD32  (350) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (839) antennal disc ML-DmD20-c5  (318) mixed discs ML-DmD4-c1  (213) CNS ML-DmBG1-c1  (374) CNS ML-DmBG2-c2  (154) tumorous blood cells mbn2  (153) ovary fGS/OSS  (119) ovary OSC  (175) ovary OSS  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (395) Schneider line 2 Sg4  (208) embryonic 1182-4H  (188) embryonic GM2    92 embryonic Kc167    64 embryonic S1  (525) embryonic S3  (225) leg disc CME L1  (246) wing disc CME-W2  (254) wing disc ML-DmD8  (185) wing disc ML-DmD9  (380) wing disc ML-DmD16-c3  135 wing disc ML-DmD21  (419) wing disc ML-DmD32  (350) haltere disc ML-DmD17-c3  (241) eye-antennal disc ML-DmD11  (839) antennal disc ML-DmD20-c5  (318) mixed discs ML-DmD4-c1  (213) CNS ML-DmBG1-c1  (374) CNS ML-DmBG2-c2  (154) tumorous blood cells mbn2  (153) ovary fGS/OSS  119 ovary OSC  (175) ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    395 Schneider line 2 Sg4    208 embryonic 1182-4H    188 embryonic GM2    92 embryonic Kc167    64 embryonic S1    525 embryonic S3    225 leg disc CME L1    246 wing disc CME-W2    254 wing disc ML-DmD8    185 wing disc ML-DmD9    380 wing disc ML-DmD16-c3    135 wing disc ML-DmD21    419 wing disc ML-DmD32    350 haltere disc ML-DmD17-c3    241 eye-antennal disc ML-DmD11    839 antennal disc ML-DmD20-c5    318 mixed discs ML-DmD4-c1    213 CNS ML-DmBG1-c1    374 CNS ML-DmBG2-c2    154 tumorous blood cells mbn2    153 ovary fGS/OSS    119 ovary OSC    175 ovary OSS    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    260 cold shock, 4-day adult    148 heat shock, 4-day adult    446 Cadmium 50 mM 6 hrs, larvae L3    532 Cadmium 50 mM 12 hrs, larvae L3    323 Cadmium 50 mM 48 hrs, 4-day adult    436 Cadmium 100 mM 48 hrs, 4-day adult    291 Copper 0.5 mM 12 hrs, larvae L3    362 Copper 15 mM 48 hrs, 4-day adult    126 Zinc 5 mM 12 hrs, larvae L3    310 Zinc 4.5 mM 48 hrs, 4-day adult    193 Ethanol 2.5% 3 hrs, larvae L3    325 Ethanol 5% 3 hrs, larvae L3    543 Ethanol 10% 3 hrs, larvae L3    639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    473 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    291 Caffeine 25 mg/ml 48 hrs, 4-day adult    184 Paraquat 5 mM 48 hrs, 4-day adult    422 Paraquat 10 mM 48 hrs, 4-day adult    395 Rotenone 2 μg 12 hrs, larvae L3    545 Rotenone 8 μg 12 hrs, larvae L3    704 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (260) cold shock, 4-day adult  (148) heat shock, 4-day adult  (446) Cadmium 50 mM 6 hrs, larvae L3  (532) Cadmium 50 mM 12 hrs, larvae L3  (323) Cadmium 50 mM 48 hrs, 4-day adult  (436) Cadmium 100 mM 48 hrs, 4-day adult  (291) Copper 0.5 mM 12 hrs, larvae L3  (362) Copper 15 mM 48 hrs, 4-day adult  (126) Zinc 5 mM 12 hrs, larvae L3  (310) Zinc 4.5 mM 48 hrs, 4-day adult  (193) Ethanol 2.5% 3 hrs, larvae L3  (325) Ethanol 5% 3 hrs, larvae L3  (543) Ethanol 10% 3 hrs, larvae L3  (639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (473) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (291) Caffeine 25 mg/ml 48 hrs, 4-day adult  (184) Paraquat 5 mM 48 hrs, 4-day adult  (422) Paraquat 10 mM 48 hrs, 4-day adult  (395) Rotenone 2 μg 12 hrs, larvae L3  (545) Rotenone 8 μg 12 hrs, larvae L3  (704) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (260) cold shock, 4-day adult  (148) heat shock, 4-day adult  (446) Cadmium 50 mM 6 hrs, larvae L3  (532) Cadmium 50 mM 12 hrs, larvae L3  (323) Cadmium 50 mM 48 hrs, 4-day adult  (436) Cadmium 100 mM 48 hrs, 4-day adult  (291) Copper 0.5 mM 12 hrs, larvae L3  (362) Copper 15 mM 48 hrs, 4-day adult  (126) Zinc 5 mM 12 hrs, larvae L3  (310) Zinc 4.5 mM 48 hrs, 4-day adult  (193) Ethanol 2.5% 3 hrs, larvae L3  (325) Ethanol 5% 3 hrs, larvae L3  (543) Ethanol 10% 3 hrs, larvae L3  (639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (473) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (291) Caffeine 25 mg/ml 48 hrs, 4-day adult  (184) Paraquat 5 mM 48 hrs, 4-day adult  (422) Paraquat 10 mM 48 hrs, 4-day adult  (395) Rotenone 2 μg 12 hrs, larvae L3  (545) Rotenone 8 μg 12 hrs, larvae L3  (704) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    260 cold shock, 4-day adult    148 heat shock, 4-day adult    446 Cadmium 50 mM 6 hrs, larvae L3    532 Cadmium 50 mM 12 hrs, larvae L3    323 Cadmium 50 mM 48 hrs, 4-day adult    436 Cadmium 100 mM 48 hrs, 4-day adult    291 Copper 0.5 mM 12 hrs, larvae L3    362 Copper 15 mM 48 hrs, 4-day adult    126 Zinc 5 mM 12 hrs, larvae L3    310 Zinc 4.5 mM 48 hrs, 4-day adult    193 Ethanol 2.5% 3 hrs, larvae L3    325 Ethanol 5% 3 hrs, larvae L3    543 Ethanol 10% 3 hrs, larvae L3    639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    473 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    291 Caffeine 25 mg/ml 48 hrs, 4-day adult    184 Paraquat 5 mM 48 hrs, 4-day adult    422 Paraquat 10 mM 48 hrs, 4-day adult    395 Rotenone 2 μg 12 hrs, larvae L3    545 Rotenone 8 μg 12 hrs, larvae L3    704 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    260 cold shock, 4-day adult    148 heat shock, 4-day adult    446 Cadmium 50 mM 6 hrs, larvae L3    532 Cadmium 50 mM 12 hrs, larvae L3    323 Cadmium 50 mM 48 hrs, 4-day adult    436 Cadmium 100 mM 48 hrs, 4-day adult    291 Copper 0.5 mM 12 hrs, larvae L3    362 Copper 15 mM 48 hrs, 4-day adult    126 Zinc 5 mM 12 hrs, larvae L3    310 Zinc 4.5 mM 48 hrs, 4-day adult    193 Ethanol 2.5% 3 hrs, larvae L3    325 Ethanol 5% 3 hrs, larvae L3    543 Ethanol 10% 3 hrs, larvae L3    639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    473 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    291 Caffeine 25 mg/ml 48 hrs, 4-day adult    184 Paraquat 5 mM 48 hrs, 4-day adult    422 Paraquat 10 mM 48 hrs, 4-day adult    395 Rotenone 2 μg 12 hrs, larvae L3    545 Rotenone 8 μg 12 hrs, larvae L3    704 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (260) cold shock, 4-day adult  (148) heat shock, 4-day adult  (446) Cadmium 50 mM 6 hrs, larvae L3  (532) Cadmium 50 mM 12 hrs, larvae L3  (323) Cadmium 50 mM 48 hrs, 4-day adult  (436) Cadmium 100 mM 48 hrs, 4-day adult  (291) Copper 0.5 mM 12 hrs, larvae L3  (362) Copper 15 mM 48 hrs, 4-day adult  (126) Zinc 5 mM 12 hrs, larvae L3  (310) Zinc 4.5 mM 48 hrs, 4-day adult  (193) Ethanol 2.5% 3 hrs, larvae L3  (325) Ethanol 5% 3 hrs, larvae L3  (543) Ethanol 10% 3 hrs, larvae L3  (639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (473) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (291) Caffeine 25 mg/ml 48 hrs, 4-day adult  (184) Paraquat 5 mM 48 hrs, 4-day adult  (422) Paraquat 10 mM 48 hrs, 4-day adult  (395) Rotenone 2 μg 12 hrs, larvae L3  (545) Rotenone 8 μg 12 hrs, larvae L3  (704) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (260) cold shock, 4-day adult  (148) heat shock, 4-day adult  (446) Cadmium 50 mM 6 hrs, larvae L3  (532) Cadmium 50 mM 12 hrs, larvae L3  (323) Cadmium 50 mM 48 hrs, 4-day adult  (436) Cadmium 100 mM 48 hrs, 4-day adult  (291) Copper 0.5 mM 12 hrs, larvae L3  (362) Copper 15 mM 48 hrs, 4-day adult  126 Zinc 5 mM 12 hrs, larvae L3  (310) Zinc 4.5 mM 48 hrs, 4-day adult  (193) Ethanol 2.5% 3 hrs, larvae L3  (325) Ethanol 5% 3 hrs, larvae L3  (543) Ethanol 10% 3 hrs, larvae L3  (639) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (473) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (291) Caffeine 25 mg/ml 48 hrs, 4-day adult  (184) Paraquat 5 mM 48 hrs, 4-day adult  (422) Paraquat 10 mM 48 hrs, 4-day adult  (395) Rotenone 2 μg 12 hrs, larvae L3  (545) Rotenone 8 μg 12 hrs, larvae L3  (704) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    260 cold shock, 4-day adult    148 heat shock, 4-day adult    446 Cadmium 50 mM 6 hrs, larvae L3    532 Cadmium 50 mM 12 hrs, larvae L3    323 Cadmium 50 mM 48 hrs, 4-day adult    436 Cadmium 100 mM 48 hrs, 4-day adult    291 Copper 0.5 mM 12 hrs, larvae L3    362 Copper 15 mM 48 hrs, 4-day adult    126 Zinc 5 mM 12 hrs, larvae L3    310 Zinc 4.5 mM 48 hrs, 4-day adult    193 Ethanol 2.5% 3 hrs, larvae L3    325 Ethanol 5% 3 hrs, larvae L3    543 Ethanol 10% 3 hrs, larvae L3    639 Caffeine 1.5 mg/ml 4 hrs, larvae L3    473 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    291 Caffeine 25 mg/ml 48 hrs, 4-day adult    184 Paraquat 5 mM 48 hrs, 4-day adult    422 Paraquat 10 mM 48 hrs, 4-day adult    395 Rotenone 2 μg 12 hrs, larvae L3    545 Rotenone 8 μg 12 hrs, larvae L3    704 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015031 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14028-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with cype1R2.5) cype03771 lethal (with cype1R15.1) cype03771 lethal (with cype03771) cype1R2.5 cype1R15.1 lethal | dominant | embryonic stage | maternal effect cype1 lethal | embryonic stage | recessive cype1 cype1R2.5 cype1R4.5 cype1R5.7 cype1R7.1 cype1R9.1 cype1R15.1 cype03771 lethal | larval stage (with Df(2L)tkv2) cype1R2.5 cype1R4.5 cype1R5.7 cype1R7.1 cype1R9.1 cype1R15.1 cype03771 lethal | recessive cype03771 partially lethal - majority die cype03771 partially lethal - majority die, with Scer\GAL4da.G32 cypeGD908 viable, with Scer\GAL4pnr-MD237 cypeGD908 cypeGD15450 Other Phenotypes Allele developmental rate defective | dominant cype1R2.5 cype1R15.1 visible, with Scer\GAL4pnr-MD237 cypeGD908 cypeGD15450 visible | dominant cype03771 visible | semidominant cype1 visible | somatic clone cype03771 wild-type cype+t3.8 Phenotype manifest in Allele abdominal 1 ventral denticle belt | maternal effect cype1 abdominal 2 ventral denticle belt | maternal effect cype1 abdominal 3 ventral denticle belt | maternal effect cype1 abdominal 4 ventral denticle belt | maternal effect cype1 abdominal 5 ventral denticle belt | maternal effect cype1 abdominal 6 ventral denticle belt | maternal effect cype1 abdominal 7 ventral denticle belt | maternal effect cype1 adult thorax cype03771 amnioserosa | maternal effect cype1 denticle belt cype03771 cype1R15.1 cype1R2.5 cype1R4.5 cype1R5.7 cype1R7.1 cype1R9.1 embryonic/first instar larval cuticle cype03771 cype1R15.1 cype1R2.5 cype1R4.5 cype1R5.7 cype1R7.1 cype1R9.1 embryonic head cype03771 cype1R15.1 cype1R2.5 cype1R4.5 cype1R5.7 cype1R7.1 cype1R9.1 eye cype03771 eye | somatic clone cype03771 filzkorper | maternal effect cype1 head | maternal effect cype1 interommatidial bristle | somatic clone cype03771 interommatidial bristle | somatic clone | supernumerary cype03771 leg cype03771 leg | maternal effect cype1 macrochaeta | somatic clone cype03771 mesothoracic tergum, with Scer\GAL4pnr-MD237 cypeGD15450 ommatidium cype03771 ommatidium | somatic clone cype03771 ovary | germline clone cype03771 tergite cype03771 thorax | maternal effect cype1 trichogen cell, with Scer\GAL4pnr-MD237 cypeGD908 wing cype03771 wing | maternal effect cype1 wing margin bristle | somatic clone cype03771
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of cype Class Mutagen Stocks Known lesion cypee03803 piggyBac transposase 2 -- cype03771 P-element activity 1 Yes cypeDP01427 1 -- cypee01552 piggyBac transposase 1 -- cypef06662 piggyBac transposase 1 -- cype1 0 -- cype1R15.1 P-element activity 0 Yes cype1R2.5 P-element activity 0 Yes cype1R4.5 P-element activity 0 Yes cype1R5.7 P-element activity 0 Yes cype1R7.1 P-element activity 0 Yes cype1R9.1 P-element activity 0 Yes cypee01551 piggyBac transposase 0 -- cypee01553 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cype Class Mutagen Stocks Known lesion cypeGD908 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cypeGD15450 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cypeHMS00815 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cypeKK111375 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cype+t3.8 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)cl1 (BDGP Project Members, 1994-1999) Df(2L)Exel6012 (Ryder, 2004.4.26) Df(2L)tkv2 (Spradling et al., 1999, Szuplewski and Terracol, 2001, BDGP Project Members, 1994-1999, George and Terracol, 1997)
Not disrupted in	Df(2L)cl7 (BDGP Project Members, 1994-1999) Df(2L)E110 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)GpdhA (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)tkv3 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD908} NA P{GD15450} NA P{KK111375} NA P{TRiP.HMS00815} NA characterization construct P{cype+t3.8} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}cype03771 No miscellaneous insertions P{3'PZ}cype1R2.5 NA P{3'PZ}cype1R4.5 NA P{3'PZ}cype1R5.7 NA P{3'PZ}cype1R15.1 NA P{?PZ}cype1R7.1 NA P{?PZ}cype1R9.1 NA PBac{RB}cypee01551 NA PBac{RB}cypee01552 NA PBac{RB}cypee01553 NA PBac{RB}cypee03803 NA PBac{WH}cypef06662 NA insertion of mobile activating element P{Mae-UAS.6.11}cypeDP01427 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cytochrome-c oxidase activity inferred from sequence or structural similarity (Terracol, 2001.4.6) inferred from sequence or structural similarity with UniProtKB:P09669 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
mitochondrial electron transport, cytochrome c to oxygen inferred from sequence or structural similarity with UniProtKB:P09669 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial respiratory chain complex IV inferred from sequence or structural similarity (Terracol, 2001.4.6) inferred from sequence or structural similarity with UniProtKB:P09669 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cype - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cype allele Gene References cype03771 cact (Szuplewski and Terracol, 2001) dpp (Szuplewski and Terracol, 2001) ea (Szuplewski and Terracol, 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70073 DroID - A comprehensive database of gene and protein interactions. • FBgn0015031 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46040
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D7ZSJ Dipteran inclusive ortholog search EOG6FN4TC Insect inclusive ortholog search EOG6NK9SQ Arthropod inclusive ortholog search EOG6PNW10 Metazoa inclusive ortholog search EOG6MPWM5
Orthologs in Drosophila Species (EOG6D7ZSJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cype     Drosophila erecta   Dere\GG25067 Y   Drosophila yakuba   Dyak\GE25385 Y   Drosophila ananassae   Dana\GF14388 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12710 Y   Drosophila persimilis   Dper\GL19570 Y   Drosophila willistoni   Dwil\GK18375 Y   Drosophila virilis   Dvir\GJ17541 Y   Drosophila mojavensis   Dmoj\GI17627 Y   Drosophila grimshawi   Dgri\GH13384 Y
Orthologs in non-Drosophila Dipterans (EOG6FN4TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009257   Anopheles gambiae Malaria mosquito  Agam\AGAP007768   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000470
Orthologs in non-Dipteran Insects (EOG6NK9SQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Cox6c   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012277   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23173   Atta cephalotes Leafcutter ant  Acep\ACEP24420   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14549   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10876   Linepithema humile Argentine ant  Lhum\LH25552   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27247   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27246   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002205   Bombyx mori Silkmoth  Bmor\BGIBMGA014175   Tribolium castaneum Red flour beetle  Tcas\TC011006   Tribolium castaneum Red flour beetle  Tcas\cox-a   Tribolium castaneum Red flour beetle  Tcas\cox-b
Orthologs in non-Insect Arthropods (EOG6PNW10)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_301871   Ixodes scapularis Deer tick  Isca\ISCW016559
Orthologs in non-Arthropod Metazoa (EOG6MPWM5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\si:ch211-239j9.2   Xenopus tropicalis Western clawed frog  Xtro\cox6c.1   Gallus gallus Domestic chicken  Ggal\COX6C   Rattus norvegicus Norway rat  Rnor\Cox6c2   Rattus norvegicus Norway rat  Rnor\LOC100365890   Homo sapiens Human  Hsap\COX6C
Human Orthologs (1)
Gene OMIM HGNC Hsap\COX6C
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG25067 Drosophila yakuba Dyak\GE25385 Drosophila ananassae Dana\GF14388 Drosophila pseudoobscura pseudoobscura Dpse\GA12710 Drosophila persimilis Dper\GL19570 Drosophila willistoni Dwil\GK18375 Drosophila virilis Dvir\GJ17541 Drosophila mojavensis Dmoj\GI17627 Drosophila grimshawi Dgri\GH13384
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	18194 w1118; PBac{RB}cypee03803/CyO 11348 P{PZ}cype03771 cn1/CyO; ry506 33878 y1 sc* v1; P{TRiP.HMS00815}attP2 22073 y1 w67c23; P{Mae-UAS.6.11}cypeDP01427/CyO
Harvard	- PBac{RB}cypee01552 - PBac{RB}cypee03803 - PBac{WH}cypef06662
VDRC	v102336 P{KK111375}VIE-260B v13403 w1118; P{GD908}v13403 v13404 w1118; P{GD908}v13404 v33841 w1118; P{GD15450}v33841
Genomic Clones ( 2 )
	BACR05M06 BACR25K01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04604
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP10225 RE61659 RH01533 RH44272 RH50151
Other clones	60513 Dmel_dig_003112_0673_3320 Dmel_dig_007049_0661_3040 Dmel_dig_009397_0681_0815 Dmel_neb_012717_0695_3330 EC15027 EK061437 EK061441 EK073029 EK200615 EK215554 EK225342 FGM001D05 FGM220D03 UUGC0214
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015031 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46040
Antibody Information
	polyclonal (Ren et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Cyc CG14028 (FlyBase, 1996-) Source for merge of: cype BcDNA:GH04604 (Misra, 2000.8.25, FlyBase, 1996-) Source for merge of: cype l(2)03771 (Szuplewski and Terracol, 2001)
Additional comments	Source for merge of cype BcDNA:GH04604 was a shared cDNA (date:030206). (Misra, 2000.8.25, FlyBase, 1996-) Source for merge of Cyc CG14028 was sequence comparison (date:010707). (FlyBase, 1996-)
Other Comments
	Mutations in cype are lethal and show pleiotropic phenotypes. (Szuplewski and Terracol, 2001) The embryonic and adult phenotypes postulate that cype is acting in the dpp transduction signal pathway. interacts genetically with: ea (Terracol and Binet, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080526 NM_001258956 NM_001258957 RefSeq (Proteins) • NP_536787 NP_001245885 NP_001245886 DDBJ / EMBL / GenBank • AAF52241 AAK32965 AAM50597 AFH03560 AFH03561 AI296358 AQ025616 AY029256 AY118737 BG632172 CZ479361 CZ479362 CZ479363 CZ489371 Entrez Gene - A searchable database of RefSeq genes. • 46040 UniProtKB/TrEMBL • Q8MSK4 Q9VMS1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome c oxidase subunit VIc (IPR004204) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME14028
Linkouts
	BioGRID - A database of protein and genetic interactions • 70073 DroID - A comprehensive database of gene and protein interactions. • FBgn0015031 DRSC - Results from RNAi screens. • FBgn0015031 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015031 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14028-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015031 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46040 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46040 modMine - Data generated by the modENCODE project. • FBgn0015031
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	BcDNA:GH04604   CG14028 (Szuplewski and Terracol, 2001, Vilain et al., 2012, Porcelli et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011) CG18323 (Wang et al., 2004) COXVIc (Fernandez-Ayala et al., 2009) cyc (Hartenstein et al., 2000) Cyc (Terracol and Binet, 1995, ) cype (Beller et al., 2006, Tripoli et al., 2005, Long et al., 2008, Jiang et al., 2009, Fernandez-Ayala et al., 2009, Porcelli et al., 2010) Cype (Ladoukakis et al., 2011) l(2)03771 (Misra, 2000.8.25, Gildea et al., 2000, Walker et al., 2000, Spradling et al., 1999, George and Terracol, 1997, Terracol and Binet, 1995, BDGP Project Members, 1994-1999, ) VIc (Ren et al., 2010)
Name Synonym	cyclope (Szuplewski and Terracol, 2001, Vilain et al., 2012, Fernandez-Ayala et al., 2009, Cammarato et al., 2011) Cyclope (Terracol and Binet, 1995) Cytochrome c oxidase Polypeptide VIc (Tripoli et al., 2005) Cytochrome c oxidase VIc (Porcelli et al., 2007) Subunit VIc (Ren et al., 2010)
Secondary FlyBase IDs
	FBgn0010553 FBgn0031699 FBgn0040947 FBgn0063275
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 )
Recent research papers ( 3 )
	Palgi et al., 2012, BMC Genomics 13: 134 Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. [FBrf0218515] Vilain et al., 2012, PLoS Genet. 8(1): e1002456 The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants. [FBrf0217195] Ladoukakis et al., 2011, Genome Biol. 12(11): R118 Hundreds of putatively functional small open reading frames in Drosophila. [FBrf0218190] Show all research papers ...