FlyBase Gene Report: Dmel\cype

General Information

Symbol

Dmel\cype

Species

D. melanogaster

Name

cyclope

Annotation Symbol

CG14028

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015031

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

cyclope (cype) encodes a cytochrome c oxidase subunit VIc homolog acting as an enhancer of dpp pathway phenotypes. It is involved in hair and cell growth and in ommatidia development. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)03771, COX6C, Cyc

Key Links

Genomic Location

Cytogenetic map

25D6-25D6

Sequence location

2L:5,327,227..5,327,969 [+]

Recombination map

2-16

RefSeq locus

NT_033779 REGION:5327227..5327969

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitochondrial electron transport, cytochrome c to oxygen

inferred by curator from GO:0045277

(Brischigliaro et al., 2022)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

located_in mitochondrion

inferred from direct assay

(Ren et al., 2010)

inferred from high throughput direct assay

(Tan et al., 2009)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in mitochondrial inner membrane

inferred from biological aspect of ancestor with PANTHER:PTN009231346

(GO Reference Genome Project, 2011-)

part_of respiratory chain complex IV

non-traceable author statement

(Porcelli et al., 2007)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS

MITOCHONDRIAL COMPLEX IV

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. Eukaryotic COX is a multimeric enzyme formed by subunits of dual genetic origin. The three subunits forming the catalytic core of the enzyme (COX1, COX2 and COX3) are encoded by the mitochondrial DNA. The non-catalytic subunits are all encoded by the nuclear DNA. The functions of these 'supernumerary subunits' are largely unknown, though are assumed to regulate complex IV activity and to coordinate energy production with cellular needs. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cype for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VMS1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0079072

396

FBtr0307034

398

FBtr0307035

460

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

cype-PA

FBpp0078707

8.3

10.46

FBpp0297877

8.3

10.46

FBpp0297878

8.3

10.46

Q9VMS1

NP_001245886

AFH03561

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

77 aa isoforms: cype-PA, cype-PB, cype-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cype using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cype_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.55

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

neuroblast

(Szuplewski and Terracol, 2001)

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally contributed

(Szuplewski and Terracol, 2001)

embryonic stage 10

organism | segmentally repeated

(Szuplewski and Terracol, 2001)

embryonic stage 13 -- 17

presumptive embryonic/larval central nervous system

(Szuplewski and Terracol, 2001)

oogenesis stage S10 & adult stage | female

follicle cell

(Szuplewski and Terracol, 2001)

adult stage | female & oogenesis stage S10

oocyte

Comment: expression stronger thanin follicle cell

(Szuplewski and Terracol, 2001)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

Comment: transcripts are more abundant in adult males

(Szuplewski and Terracol, 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

located_in mitochondrion

inferred from direct assay

(Ren et al., 2010)

inferred from high throughput direct assay

(Tan et al., 2009)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Expression Deduced from Reporters

Reporter: P{PZ}cype⁰³⁷⁷¹

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

neuroblast

(Szuplewski and Terracol, 2001)

embryonic stage 17

larval central nervous system

(Szuplewski and Terracol, 2001)

third instar larval stage

leg disc | central

(Szuplewski and Terracol, 2001)

antennal disc | central

(Szuplewski and Terracol, 2001)

eye disc | central

(Szuplewski and Terracol, 2001)

third instar larval stage | male

testis

(Szuplewski and Terracol, 2001)

adult stage | female

germarium

(Szuplewski and Terracol, 2001)

adult stage | male

testis

(Szuplewski and Terracol, 2001)

adult stage | female & oogenesis stage S10

nurse cell

(Szuplewski and Terracol, 2001)

follicle cell

(Szuplewski and Terracol, 2001)

adult stage | male & spermatogenesis

spermatozoon

(Szuplewski and Terracol, 2001)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cype in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cype

View exonic expression by tissue for Dmel\cype

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46040/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015031

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015031

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015031

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14028

Flygut - An atlas of the Drosophila adult midgut

FBgn0015031

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cype

Transgenic constructs containing regulatory region of cype

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(2L)cl1

(BDGP Project Members, 1994-1999)

Df(2L)Exel6012

(Ryder, 2004.4.26)

Df(2L)tkv2

(Szuplewski and Terracol, 2001, Spradling et al., 1999, George and Terracol, 1997, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2L)cl7

(BDGP Project Members, 1994-1999)

Df(2L)E110

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)Gpdh1-A

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)tkv3

(BDGP Project Members, 1994-1999)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

cype^GD908

lethal (with cype^1R2.5)

cype⁰³⁷⁷¹

lethal (with cype^1R15.1)

cype⁰³⁷⁷¹

lethal (with cype⁰³⁷⁷¹)

lethal | dominant | embryonic stage | maternal effect

cype⁰³⁷⁷¹

lethal | embryonic stage | recessive

cype⁰³⁷⁷¹

lethal | recessive

cype⁰³⁷⁷¹

lethal - all die before end of larval stage (with Df(2L)tkv2)

lethal - all die during embryonic stage | recessive

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

cype^GD15450

partially lethal - majority die

cype⁰³⁷⁷¹

partially lethal - majority die, with Scer\GAL4^da.G32

cype^GD908

partially lethal - majority die | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

cype^GD908

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cype^GD15450

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal developmental rate | dominant

abnormal developmental rate | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

cype^GD908

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cype^GD908

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

cype^HMS00815

some die during embryonic stage | recessive

some die during larval stage (with Df(2L)tkv2)

visible, with Scer\GAL4^pnr-MD237

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

cype^HMS00815

visible | dominant

cype⁰³⁷⁷¹

visible | semidominant

cype⁰³⁷⁷¹

visible | somatic clone

cype⁰³⁷⁷¹

wild-type

cype^+t3.8

Phenotype manifest in

Allele

abdominal 1 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal 2 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal 3 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal 4 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal 5 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal 6 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal 7 ventral denticle belt | maternal effect

cype⁰³⁷⁷¹

abdominal tergite

cype⁰³⁷⁷¹

adult thorax

cype⁰³⁷⁷¹

amnioserosa | maternal effect

cype⁰³⁷⁷¹

embryonic/first instar larval cuticle

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

cype^HMS00815

embryonic head

eye

cype⁰³⁷⁷¹

eye, with Scer\GAL4^eya.enh1+E+2

cype^HMS00815

eye | somatic clone

cype⁰³⁷⁷¹

filzkorper | maternal effect

cype⁰³⁷⁷¹

head | maternal effect

cype⁰³⁷⁷¹

interommatidial bristle | somatic clone

cype⁰³⁷⁷¹

interommatidial bristle | somatic clone | increased number

cype⁰³⁷⁷¹

leg

cype⁰³⁷⁷¹

leg | maternal effect

cype⁰³⁷⁷¹

macrochaeta | somatic clone

cype⁰³⁷⁷¹

mesonotum, with Scer\GAL4^pnr-MD237

cype^GD15450

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

cype^HMS00815

ommatidium

cype⁰³⁷⁷¹

ommatidium | somatic clone

cype⁰³⁷⁷¹

ovary | germline clone

cype⁰³⁷⁷¹

thorax | maternal effect

cype⁰³⁷⁷¹

trichogen cell, with Scer\GAL4^pnr-MD237

cype^GD908

ventral denticle belt

wing

cype⁰³⁷⁷¹

wing | maternal effect

cype⁰³⁷⁷¹

wing margin bristle | somatic clone

cype⁰³⁷⁷¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\COX6C

10 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Cox6c

11 of 14

Yes

Rnor\Cox6c-ps1

8 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Cox6c

10 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\cox6c

6 of 13

Yes

Xtro\LOC100489195

1 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\cox6c

11 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\Y111B2A.2

2 of 14

Yes

Cele\B0035.18

1 of 14

Yes

Cele\cox-6C

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP007768

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cype. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

COX6CL

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex IV dysfunction, general model

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

cype^GD908

model of cytochrome-c oxidase deficiency disease

CEA

(Kemppainen et al., 2014)

cype^KK111375

model of cytochrome-c oxidase deficiency disease

CEA

(Brischigliaro et al., 2022)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

cype^GD908

model of cytochrome-c oxidase deficiency disease

is ameliorated by Zzzz\AOX^αTub84B.PK

(Kemppainen et al., 2014)

is ameliorated by Cint\AOX^αTub84B.PK

(Kemppainen et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

COX6C; cytochrome c oxidase subunit 6C

10 of 14

124090

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cype - COX4

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

cype - COX5A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

cype - COX5B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

cype - COX6B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

cype - COX7A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

cype - COX7AL2

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

cype - COX7B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

cype - COX8

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

cype - ND-MLRQ

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

cype - levy

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

cype - mt:CoI

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

cype - mt:CoII

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

cype - mt:CoIII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dpp

enhanceable

cype

(Szuplewski and Terracol, 2001)

enhanceable

cype

(Szuplewski and Terracol, 2001)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

70073

DroID - A comprehensive database of gene and protein interactions.

FBgn0015031

MIST (protein-protein) - An integrated Molecular Interaction Database

46040

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-16

Cytogenetic map

25D6-25D6

Sequence location

2L:5,327,227..5,327,969 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25D6-25D6

Limits computationally determined from genome sequence between P{lacW}vri^k05901&P{PZ}cype⁰³⁷⁷¹ and P{lacW}Hel25E^k11511

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

25D4-25D6

(Terracol, 2001.4.6, BDGP Project Members, 1994-1999)

25D4-25D6

(determined by in situ hybridisation)

(Spradling et al., 1999)

Experimentally Determined Recombination Data

Location

2-16

(FlyBase, 2016)

2-17.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18194

w¹¹¹⁸; PBac{RB}cype^e03803/CyO

11348

P{PZ}cype⁰³⁷⁷¹ cn¹/CyO; ry⁵⁰⁶

22073

y¹ w^67c23; P{Mae-UAS.6.11}cype^DP01427/CyO

78084

P{cype^+t3.8}1, w¹¹¹⁸; P{3'PZ}cype^1R2.5/CyO

78085

P{cype^+t3.8}1, w¹¹¹⁸; P{3'PZ}cype^1R4.5/CyO

78086

P{cype^+t3.8}1, w¹¹¹⁸; P{3'PZ}cype^1R15.1/CyO

33878

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00815}attP2

NIG-Fly

M2L-1069

y¹ w¹¹¹⁸; cype^SK1 P{neoFRT}40A/CyO-Tb

M2L-1070

y¹ w¹¹¹⁸; cype^SK4 P{neoFRT}40A/CyO-Tb

HMS00815

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00815}attP2

VDRC

v102336

P{KK111375}VIE-260B

v13403

w¹¹¹⁸; P{GD908}v13403

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH04604

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015031

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015031

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ren et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mutations in cype are lethal and show pleiotropic phenotypes.

(Szuplewski and Terracol, 2001)

The embryonic and adult phenotypes postulate that cype is acting in the dpp transduction signal pathway. interacts genetically with: ea

(Terracol and Binet, 1995)

Relationship to Other Genes

Source for database merge of

Source for merge of: cype l(2)03771

(Szuplewski and Terracol, 2001)

Source for merge of: cype BcDNA:GH04604

(Misra, 2000.8.25, FlyBase, 1996-)

Source for merge of: Cyc CG14028

(FlyBase, 1996-)

Additional comments

Source for merge of cype BcDNA:GH04604 was a shared cDNA ( date:030206 ).

(Misra, 2000.8.25, FlyBase, 1996-)

Source for merge of Cyc CG14028 was sequence comparison ( date:010707 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

BcDNA:GH04604

CG14028

(Curcio et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Foriel et al., 2015, Hosono et al., 2015, Kemppainen et al., 2014, Jaspers et al., 2012, Vilain et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Porcelli et al., 2007, Caggese et al., 2006, Szuplewski and Terracol, 2001)

CG18323

(Wang et al., 2004)

COX6C

(Brischigliaro et al., 2022, Porcelli and Marygold, 2014.9.16)

COXH

(Caggese et al., 2006)

COXVIc

(Fernandez-Ayala et al., 2009)

Cox6c

(Kemppainen et al., 2014)

Cyc

(Terracol and Binet, 1995)

Cype

(Ladoukakis et al., 2011)

Q9VMS1

(Ebanks et al., 2021)

VIc

(Ren et al., 2010)

cyc

(Hartenstein et al., 2000)

l(2)03771

(Gildea et al., 2000, Misra, 2000.8.25, Walker et al., 2000, Spradling et al., 1999, George and Terracol, 1997, Terracol and Binet, 1995, BDGP Project Members, 1994-1999)

Name Synonyms

Cyclope

(Terracol and Binet, 1995)

Cytochrome c oxidase Polypeptide VIc

(Tripoli et al., 2005)

Cytochrome c oxidase VIc

(Porcelli et al., 2007)

Cytochrome c oxidase polypeptide VIc

(Caggese et al., 2006)

Cytochrome c oxidase subunit 6C

(Porcelli and Marygold, 2014.9.16)

Subunit VIc

(Ren et al., 2010)

cyclope

(O'Hanlon et al., 2022, Kemppainen et al., 2014, Porcelli and Marygold, 2014.9.16, Jaspers et al., 2012, Vilain et al., 2012, Cammarato et al., 2011, Fernandez-Ayala et al., 2009, Szuplewski and Terracol, 2001)

Secondary FlyBase IDs

FBgn0010553
FBgn0031699
FBgn0040947
FBgn0063275

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46040

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VMS1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VMS1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46040/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015031

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015031

FlyMine - An integrated database for Drosophila genomics

FBgn0015031

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG14028

MARRVEL_MODEL - MARRVEL (model organism gene)

46040

Linkouts

BioGRID - A database of protein and genetic interactions.

70073

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015031

DroID - A comprehensive database of gene and protein interactions.

FBgn0015031

DRSC - Results frm RNAi screens

FBgn0015031

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cype_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015031

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015031

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14028

Flygut - An atlas of the Drosophila adult midgut

FBgn0015031

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

46040

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (94)

The following external sites may use different assemblies or annotations than FlyBase.

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