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Gene Dyak\Mlc1

General Information
Symbol	Dyak\Mlc1	Species	D. yakuba
Name	Myosin alkali light chain 1	Annotation symbol	GE10549
Feature type	protein_coding_gene	FlyBase ID	FBgn0015215
Gene Model Status	Current	Stock availability	None publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map		Sequence location	3R:23,001,449..23,003,539 [+]
Genomic Maps	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Myosin alkali light chain 1 is referred to in FlyBase by the symbol Dyak\Mlc1 (GE10549, FBgn0015215). It is a protein_coding_gene from Drosophila yakuba. Based on sequence similarity, it is predicted to have molecular function: microfilament motor activity. Based on sequence similarity, it is predicted to be involved in the biological process: muscle contraction. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: Calcium-binding EF-hand; EF-hand-like domain. Gene sequence location is 3R:23001449..23003539.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dyak\Mlc1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dyak\Mlc1-RA FBtr0257067  XM_002098732   468   155
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dyak\Mlc1-PA   FBpp0255559   17.6   155   4.00     XP_002098768   EDW98480
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EF-hand-like domain (IPR011992) EF-hand domain (IPR002048)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AY231977 AAR10000   CM000160 EDW98480   L49007 AAC37270   L49007 AAC37271
UniProtKB/Swiss-Prot	Q24766
UniProtKB/TrEMBL	B4PRB6 Q6XI55
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Dyak\Mlc1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dyak\Mlc1 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR011992 (FlyBase Curators et al., 2004-) microfilament motor activity inferred from sequence or structural similarity with UniProtKB:P06742 (Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
muscle contraction inferred from sequence or structural similarity with UniProtKB:P06742 (Swiss-Prot Project Members, 2000.10.1)
Cellular Component
CV term Evidence References
muscle myosin complex inferred from sequence or structural similarity with UniProtKB:P06742 (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	gene   nuclear_gene (Drosophila 12 Genomes Consortium, 2008) protein_coding_gene (Drosophila 12 Genomes Consortium, 2008)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dyak\Mlc1 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (1) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6HQF4X Dipteran inclusive ortholog search EOG6PVP81 Insect inclusive ortholog search EOG64TN5B Arthropod inclusive ortholog search EOG6C5B1W Metazoa inclusive ortholog search No orthologs identified
Ortholog(s) in Drosophila melanogaster (EOG6HQF4X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mlc1 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila melanogaster Dmel\Mlc1
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • XM_002098732 RefSeq (Proteins) • XP_002098768 DDBJ / EMBL / GenBank • AAC37270 AAC37271 AAR10000 AY231977 EDW98480 L49007 Entrez Gene - A searchable database of RefSeq genes. • 6538241 UniProtKB/Swiss-Prot • Q24766 UniProtKB/TrEMBL • B4PRB6 Q6XI55
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EF-hand-like domain (IPR011992) EF-hand domain (IPR002048)
Linkouts
	FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015215
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	dyak_GLEANR_10464 (Drosophila 12 Genomes Consortium, 2008) Dyak\Mlc1 (Drosophila 12 Genomes Consortium, 2008) Mlc1 (Drosophila 12 Genomes Consortium, 2008)
Name Synonym	Myosin alkali light chain 1
Secondary FlyBase IDs
References ( 12 )
Research paper	Drosophila 12 Genomes Consortium et al., 2007, Nature 450(7167): 203--218 Evolution of genes and genomes on the Drosophila phylogeny. [FBrf0200326] Carbone et al., 2005, Genetics 171(1): 211--225 Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea. [FBrf0187632] Llopart et al., 2005, Genetics 171(1): 197--210 Multilocus analysis of introgression between two sympatric sister species of Drosophila: Drosophila yakuba and D. santomea. [FBrf0187647] Domazet-Loso and Tautz, 2003, Genome Res. 13(10): 2213--2219 An evolutionary analysis of orphan genes in Drosophila. [FBrf0167691] Moriyama and Powell, 1997, J. Mol. Evol. 45(4): 378--391 Synonymous substitution rates in Drosophila: mitochondrial versus nuclear genes. [FBrf0098855] Clark et al., 1996, Mol. Biol. Evol. 13(3): 471--482 Length variation and secondary structure of introns in the Mlc1 gene in six species of Drosophila. [FBrf0086357] Clark et al., 1995, Mol. Biol. Evol. 12(5): 902--913 Molecular evolution of P transposable elements in the genus Drosophila. [FBrf0083083]
Personal communication to FlyBase	Drosophila 12 Genomes Consortium, 2008, personal communication to FlyBase Symbols and class of gene information for the GLEANR consensus sequences of the 11 sequenced non-melanogaster Drosophila species (Drosophila ananassae, erecta, grimshawi, mojavensis, persimilis, pseudoobscura, sechellia, simulans, willistoni, virilis and yakuba). [FBrf0202436] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 2008, Newly sequenced Drosophila genomes: associations of GLEANR gene predictions (Releases 1.0) with previously known genes in FlyBase. Newly sequenced Drosophila genomes: associations of GLEANR gene predictions (Releases 1.0) with previously known genes in FlyBase. [FBrf0202439]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q24766 MYOSIN LIGHT CHAIN ALKALI (CATALYTIC) (FRAGMENT). [FBrf0136600]
DNA/RNA sequence record	Clark, 1996.12.3, GenBank/EMBL/DDBJ: L49007 Drosophila yakuba Mlc1 gene, larval and non-IFM isoform, indirect flight muscle isoform, 3' end of cds. [FBrf0113909]