Open Close
General Information
Symbol
Dmel\eIF4E1
Species
D. melanogaster
Name
eukaryotic translation initiation factor 4E1
Annotation Symbol
CG4035
Feature Type
FlyBase ID
FBgn0015218
Gene Model Status
Stock Availability
Gene Snapshot
eukaryotic translation initiation factor 4E1 (eIF4E1) encodes a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. The product of eIF4E1 binds the 7-methyl-guanosine cap structure of mRNA. [Date last reviewed: 2019-03-07]
Also Known As
eIF4E, eIF-4E, eIF4E-1, eIF4E-2, deIF4E
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:9,399,618..9,402,460 [-]
Recombination map
3-29
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the eukaryotic initiation factor 4E family. (P48598)
Summaries
Gene Group (FlyBase)
CYTOPLASMIC TRANSLATION INITIATION FACTORS -
Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).
Protein Function (UniProtKB)
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition (PubMed:28875934).
(UniProt, P48598)
Summary (Interactive Fly)
binds to the mRNA 5' cap thus controlling a crucial step in translation initiation - required for cell growth - promotes dedifferentiation of neuroblasts back to a stem cell-like state thus functioning as an oncogene - a target of Ago2 in translational repression - functions as a splice factor for and pre-mRNAs
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\eIF4E1 or the JBrowse view of Dmel\eIF4E1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076490
1430
259
FBtr0076487
1484
259
FBtr0076488
1156
248
FBtr0076489
1723
259
FBtr0076492
1524
259
FBtr0076493
1452
259
FBtr0076491
1358
259
FBtr0333884
1492
259
FBtr0333885
1793
259
Additional Transcript Data and Comments
Reported size (kB)
2.0, 1.7, 1.4 (northern blot)
2.0, 1.5, 1.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076218
29.2
259
6.17
FBpp0076215
29.2
259
6.17
FBpp0076216
27.8
248
5.04
FBpp0076217
29.2
259
6.17
FBpp0076220
29.2
259
6.17
FBpp0076221
29.2
259
6.17
FBpp0076219
29.2
259
6.17
FBpp0306016
29.2
259
6.17
FBpp0306017
29.2
259
6.17
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. eIF4E1 is also known to interact with other partners (By similarity). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G. The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14691132, PubMed:14723848, PubMed:14685270, PubMed:26294658). Interacts with mxt (PubMed:23716590, PubMed:26294658). Interacts with 4E-T and Thor (PubMed:26294658). Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).
(UniProt, P48598)
Post Translational Modification
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
(UniProt, P48598)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4E1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Thor; FB:FBgn0261560
inferred from physical interaction with UniProtKB:Q9VD44
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from genetic interaction with SGD:S000005499
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:3287
inferred from sequence or structural similarity with MGI:MGI:95305
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(assigned by GO_Central )
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from genetic interaction with SGD:S000005499
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with HGNC:3287
inferred from sequence or structural similarity with MGI:MGI:95305
Cellular Component (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with HGNC:3287
inferred from sequence or structural similarity with MGI:MGI:95305
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(assigned by GO_Central )
non-traceable author statement
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P63073
(assigned by UniProt )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
eIF-4E transcripts are expressed throughout embryogenesis in all cells. They accumulate at higher levels in some tissues at certain developmental stages. Transcripts preferentially accumulate in the pole cells from early stages up through germ band extension. Transcripts accumulate at high levels in the endodermal primordia that will give rise to the anterior and posterior midguts as well as in the mesodermal layer and the salivary gland primordia. At later stages, high expression is observed in the endodermal layer of the gut and in th somatic muscle.
The 1.4kb eIF-4E transcript is lower in abundance than the larger two in early embryos.
eIF-4E transcripts are detected throughout development on northern blots.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
eIF4E1 protein is expressed during many stages of spermatogenesis, both in the germ cells and surrounding somatic cyst cells. eIF4E1 protein is detected in the hub cells containing the stem cell niche at the apical tip of the testes, in spermatogonia, primary and secondary spermatocytes,and in spermatids in the early stages elongation. eIF4E1 protein is not detected in mature elongated spermatid bundles undergoing differentiation, but is detected in surrounding somatic cyst cells.
eIF-4E protein is expressed in all tissues analyzed.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eIF4E1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eIF4E1
Transgenic constructs containing regulatory region of eIF4E1
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
mitosis & nuclear chromosome
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
13 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
12 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
10 of 13
Yes
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
10 of 12
Yes
Yes
7 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (11)
13 of 15
Yes
Yes
13 of 15
Yes
Yes
11 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
13 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
Yes
6 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
9 of 9
Yes
Yes
8 of 9
No
Yes
7 of 9
No
Yes
6 of 9
No
Yes
2 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
14 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
11 of 12
Yes
Yes
11 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190FJK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915084N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08OG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08K0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0IVA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
10 of 10
8 of 10
7 of 10
7 of 10
6 of 10
3 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. eIF4E1 is also known to interact with other partners (By similarity). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G. The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14691132, PubMed:14723848, PubMed:14685270, PubMed:26294658). Interacts with mxt (PubMed:23716590, PubMed:26294658). Interacts with 4E-T and Thor (PubMed:26294658). Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).
    (UniProt, P48598 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-29
    Cytogenetic map
    Sequence location
    3L:9,399,618..9,402,460 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    67B4-67B4
    Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    67A8-67B2
    67B1-67B2
    (determined by in situ hybridisation)
    67B-67B
    (determined by in situ hybridisation)
    67A8-67B2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (22)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (158)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: eIF4E1 eIF-4E
    Source for database merge of
    Source for merge of: eIF-4E l(3)S025007 l(3)S026009 l(3)S058711 l(3)S091912
    Source for merge of: eIF-4E l(3)07238
    Source for merge of: eIF-4E l(3)67Af
    Additional comments
    Other Comments
    RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
    dsRNA made from templates generated with primers directed against this gene reduces mean cell diameter. Silencing both eIF-4E and S6k together does not reduce mean cell diameter to the same extent as rapamycin treatment.
    cup is required to localise eIF-4E to the posterior of the oocyte.
    eIF-4E is phosphorylated on Ser251.
    The phosphorylation of eIF-4E at Ser251 is biologically significant and is essential for normal growth and development.
    Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
    Cloning and sequencing of eIF-4E revealed the existance of three mRNAs that are generated by alternative splicing of a primary transcript and all have different 5' untranslated leader regions. eIF-4E is a single copy gene. Expression of eIF-4E is spatially and temporally controlled during embryonic development. eIF-4E is ubiquitously expressed during embryogenesis but transcripts preferentially accumulate in certain tissues, particularly in the pole cells at different developmental stages.
    eIF-4E produces two different cap-binding proteins by alternative splicing.
    eIF-4E protein from both control and heat shocked cells has been purified and characterised.
    Isolated from a 0 to 20 hour embryo cDNA library using a polyclonal antibody against eIF-4E.
    An eIF-4E cDNA has been cloned and sequenced, and its expression pattern has been analysed.
    Drosophila elongation factor 4F consists of two subunits, a polypeptide of about 200kD and the product of eIF-4E, the cap-binding protein.
    Drosophila initiation factor eIF-4F is composed of two subunits, one is encoded by eIF-4E and the other by eIF-4G, a 200kD protein.
    Translation of the majority of non-heat shock mRNAs and Hsp83 mRNA is very dependent on eIF-4E. In contrast, translation of Hsp70 mRNAs and to a lesser extent the mRNAs for the small heat shock proteins is almost independent of eIF-4E.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 107 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (52)
    Reported As
    Symbol Synonym
    Eif4E
    eIF4E
    (Ruscica et al., 2019, Von Stetina et al., 2018, Wang et al., 2018, Broyer et al., 2017, Ma et al., 2017, Wang et al., 2017, Grüner et al., 2016, Penney et al., 2016, Sanchez et al., 2016, Ghosh and Lasko, 2015, Menon et al., 2015, Peter et al., 2015, Yan et al., 2015, Igreja et al., 2014, Majzoub et al., 2014, Zacharogianni et al., 2014, Nishihara et al., 2013, Olson et al., 2013, Zekri et al., 2013, Ferrero et al., 2012, Killip and Grewal, 2012, Mihailovich et al., 2012, Ganesan et al., 2011, Jeske et al., 2011, Lim et al., 2011, Ottone et al., 2011, Read, 2011, Singh et al., 2011, Yarunin et al., 2011, Cauchi et al., 2010, Garrey et al., 2010, Gehrke et al., 2010, Jäger and Dorner, 2010, Liu and Lu, 2010, Duncan et al., 2009, Farny et al., 2009, Iwasaki et al., 2009, Lee et al., 2009, Nie et al., 2009, Nuzhdin et al., 2009, Read et al., 2009, Shen et al., 2009, Duncan, 2008, Hernandez et al., 2008, Hughes et al., 2008, Imai et al., 2008, Kwak et al., 2008, Layalle et al., 2008, McNeill et al., 2008, Teleman et al., 2008, Franklin-Dumont et al., 2007, Grewal et al., 2007, Lasko and Sonenberg, 2007, Lee et al., 2007, Lee et al., 2007, Liu and Gall, 2007, Baker and Fuller, 2006, Kozak, 2006, Li and Li, 2006, Bourouis et al., 2005, Cho et al., 2005, Macdonald, 2005, Parra-Palau et al., 2005, Reiling et al., 2005, Semotok et al., 2005, Teleman et al., 2005, Graham et al., 2004, Hernandez et al., 2004, Jenkins and Lasko, 2004, Macdonald, 2004, Wilhelm et al., 2004, Yan and Macdonald, 2004, Zappavigna et al., 2004, Chakkalakal and Jasmin, 2003, Gamberi et al., 2003, Graham et al., 2003, Oldham and Hafen, 2003, Wilhelm et al., 2003, Wilhelm et al., 2003, Darnell, 2002, Lachance et al., 2002, Niessing et al., 2002, Saucedo and Edgar, 2002, Sigrist et al., 2002, Van Buskirk and Schupbach, 2002, Graham et al., 2001, Bernal and Kimbrell, 2000, Carrera et al., 2000, DiAntonio, 2000, Graham et al., 2000, Lasko, 2000, Miron et al., 2000, Schoenfeld et al., 2000, Sigrist et al., 2000, Lachance et al., 1999, Lehner, 1999, Miron et al., 1999, Lachance et al., 1998, Lachance and Lasko, 1997, Miron et al., 1997, Lasko, 1996.4.9, Lavoie et al., 1996)
    l(3)S025007
    l(3)S026009
    l(3)S058711
    l(3)S091912
    Name Synonyms
    Eukaryotic translation initiation factor 4E
    cap binding protein
    eukaryotic translation initiation factor 4E
    eukaryotic translation initiation factor 4E1
    lethal(3)67Af
    Secondary FlyBase IDs
    • FBgn0002202
    • FBgn0010921
    • FBgn0013947
    • FBgn0028178
    • FBgn0035984
    • FBgn0060598
    • FBgn0060792
    • FBgn0061015
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (283)