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Gene Dmel\Fer2LCH

General Information
Symbol	Dmel\Fer2LCH	Species	D. melanogaster
Name	Ferritin 2 light chain homologue	Annotation symbol	CG1469
Feature type	protein_coding_gene	FlyBase ID	FBgn0015221
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	l(3)neo60, l(3)neo63, l(3)00035
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99F2-99F2	Sequence location	3R:26,213,554..26,216,306 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ferritin 2 light chain homologue is referred to in FlyBase by the symbol Dmel\Fer2LCH (CG1469, FBgn0015221). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ferrous iron binding. There is experimental evidence that it is involved in the biological process: chaeta development; cellular iron ion homeostasis. 45 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Ferritin; Ferritin-like; Ferritin-related; Ferritin/DPS protein domain; Ferritin/ribonucleotide reductase-like. Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636186_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Fer2LCH. Gene sequence location is 3R:26213554..26216306.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features BKN23769 HFA16672
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99F2-99F2   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99F1-99F1     (Dunkov, 1999.4.22) 99F1-99F1     (Dunkov, 1999.4.22) 99F1-99F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 99F1-99F2     (Dunkov and Law, 1999.3.20) 65A5-65A6   70A1--2 71B4--5 73A9--10 91F1--5 97E1--F11 99A1--11 99F1--4   (BDGP Project Members, 1994-1999) 99F-99F   (determined by in situ hybridisation)   (Berg and Spradling, 1991) 99F-99F   (determined by in situ hybridisation) 97E--F (determined by in situ hybridisation)   (Cooley et al., 1988) 97F-97F   S. Wasserman's group have refined the mapping of the P-element in Fer2LCHneo60. (determined by in situ hybridisation)   (Gonzalez-Reyes, 1995.8.1)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fer2LCH for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fer2LCH-RA FBtr0085622  NM_080063   1256   227 Fer2LCH-RB FBtr0085623  NM_170483   1443   227 Fer2LCH-RC FBtr0085624  NM_170484   1078   227
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fer2LCH-PA   FBpp0084986   25.2   227   6.30     NP_524802   AAF57038 Fer2LCH-PB   FBpp0084987   25.2   227   6.30     NP_733362   AAN14228 Fer2LCH-PC   FBpp0084988   25.2   227   6.30     NP_733363   AAN14229
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ferritin/DPS protein domain (IPR008331) Ferritin-like (IPR009040) Ferritin/ribonucleotide reductase-like (IPR009078) Ferritin-related (IPR012347) Ferritin (IPR001519)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202474   AA246660   AA391342   AA392137   AA695744   AA696012   AA696792   AA697193   AA802596   AA940650   AE014297 AAF57038   AE014297 AAN14228   AE014297 AAN14229   AF145124 AAF07876   AF145126 AAF07879   AI295271   AI467773   AI945133   AI947080   AQ025156   AQ026351   AQ026352   AQ073305   AQ073940   AY070805 AAL48427   BE976436   BE978501   BF485589   BF486477   BF486621   BF488230   BF489671   BF498322   BF501443   BF502037   BF505419   BG634093   BI163424   BI173325   BI241407   BI241485   BQ102643   BQ103690   CA804309   CA805899   CA806187   CA806709   CA806898   CA807616   CK657410   CK659954   CK661523   CK662353   CO177816   CO178947   CO188538   CO190186   CO193454   CO195444   CO195622   CO269081   CO295862   CO298164   CO298175   CO299424   CO307525   CO309180   CO318465   CO319371   CO319996   CW848173   CZ466577   CZ468262   CZ468263   CZ471311   CZ474320   CZ474386   CZ474387   CZ476651   CZ476652   CZ476654   CZ477084   CZ477790   CZ479007   CZ481207   CZ489532   EC061978   EC066039   EC066821   EC067114   EC069463   EC074593   EC075526   EC077771   EC078286   EC195882   EC196683   EC197233   EC205245   EC211090   EC217837   EC229155   EC232648   EC234156   EC236357   EC240522   EC244694   EC249445   EL883475   ES689844   ES689846   ES689848   ES689849   ES689854   ES689856   ES689857   ES689858   ES689859   ES689862   ES689863   ES689864   ES689865   ES689866   ES689868   ES689871   ES689872   ES689875   ES689878   ES689881   ES689885   ES689886   ES689887   ES689890   ES689891   ES689894   ES689895   ES689900   ES689904   ES689905   ES689907   ES689908   ES689909   ES689910   ES689911   ES689913   ES689914   ES689915   ES689916   ES689918   ES689919   ES689922   ES689927   ES689933   ES689936   ES689942   ES689946   ES689947   ES689948   ES689949   ES689951   ES689954   ES689957   ES689959   ES689961   ES689962   ES689963   ES691989   ES691991   ES691992   ES691993   ES691994   ES691995   ES691996   ES691997   ES691998   ES691999   ES692000   ES692001   ES692002   ES692003   ES692004   ES692005   ES692006   ES692008   ES692009   ES692010   ES692012   ES692014   ES692015   ES692017   ES692018   ES692019   ES692020   ES692021   ES692022   ES692023   ES692024   ES692025   ES692026   ES692027   ES692028   ES692030   ES692031   ES692032   ES692033   ES692034   ES692035   ES692036   ES692037   ES692038   ES692039   ES692040   ES692041   ES692042   ES692043   ES692044   ES692045   ES692046   ES692047   ES692048   ES692049   ES692050   ES692051   ES692052   ES692053   ES692054   ES692055   ES692056   ES692057   ES692058   ES692059   ES692060   ES692061   ES692062   ES692063   ES692064   ES692065   ES692066   ES692068   ES692069   ES692070   ES692071   ES692075   ES692076   ES692077   ES692078   ES692080   ES692730   ES692732   ES692733   ES692735   ES692736   ES692737   ES692741   ES692743   ES692744   ES692745   ES692746   ES692748   EV574823   EV579992   EV580768   EV583560   EV588846   EV590522
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9U4U2 Q9U7A3 Q9VA83
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015221    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015221 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015221 expression level Developmental Stage   Expression Level embryo 00-02hr    13932 embryo 02-04hr    21275 embryo 04-06hr    18543 embryo 06-08hr    15721 embryo 08-10hr    18692 embryo 10-12hr    17554 embryo 12-14hr    19977 embryo 14-16hr    16909 embryo 16-18hr    17067 embryo 18-20hr    19660 embryo 20-22hr    20030 embryo 22-24hr    22980 larva L1    28974 larva L2    30945 larva L3 12hr old    27009 larva L3 puffstage 1-2    46324 larva L3 puffstage 3-6    42748 larva L3 puffstage 7-9    41999 white prepupae new    41239 white prepupae 12hr    31888 white prepupae 24hr    29795 pupae 2d postWPP    25740 pupae 3d postWPP    17501 pupae 4d postWPP    14305 adult male 01day    31638 adult male 05day    30159 adult male 30day    28709 adult female 01day    24858 adult female 05day    25254 adult female 30day    31949 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13932) embryo 02-04hr  (21275) embryo 04-06hr  (18543) embryo 06-08hr  (15721) embryo 08-10hr  (18692) embryo 10-12hr  (17554) embryo 12-14hr  (19977) embryo 14-16hr  (16909) embryo 16-18hr  (17067) embryo 18-20hr  (19660) embryo 20-22hr  (20030) embryo 22-24hr  (22980) larva L1  (28974) larva L2  (30945) larva L3 12hr old  (27009) larva L3 puffstage 1-2  (46324) larva L3 puffstage 3-6  (42748) larva L3 puffstage 7-9  (41999) white prepupae new  (41239) white prepupae 12hr  (31888) white prepupae 24hr  (29795) pupae 2d postWPP  (25740) pupae 3d postWPP  (17501) pupae 4d postWPP  (14305) adult male 01day  (31638) adult male 05day  (30159) adult male 30day  (28709) adult female 01day  (24858) adult female 05day  (25254) adult female 30day  (31949) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13932) embryo 02-04hr  (21275) embryo 04-06hr  (18543) embryo 06-08hr  (15721) embryo 08-10hr  (18692) embryo 10-12hr  (17554) embryo 12-14hr  (19977) embryo 14-16hr  (16909) embryo 16-18hr  (17067) embryo 18-20hr  (19660) embryo 20-22hr  (20030) embryo 22-24hr  (22980) larva L1  (28974) larva L2  (30945) larva L3 12hr old  (27009) larva L3 puffstage 1-2  (46324) larva L3 puffstage 3-6  (42748) larva L3 puffstage 7-9  (41999) white prepupae new  (41239) white prepupae 12hr  (31888) white prepupae 24hr  (29795) pupae 2d postWPP  (25740) pupae 3d postWPP  (17501) pupae 4d postWPP  (14305) adult male 01day  (31638) adult male 05day  (30159) adult male 30day  (28709) adult female 01day  (24858) adult female 05day  (25254) adult female 30day  (31949) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (13932) embryo 02-04hr  (21275) embryo 04-06hr  (18543) embryo 06-08hr  (15721) embryo 08-10hr  (18692) embryo 10-12hr  (17554) embryo 12-14hr  (19977) embryo 14-16hr  (16909) embryo 16-18hr  (17067) embryo 18-20hr  (19660) embryo 20-22hr  (20030) embryo 22-24hr  (22980) larva L1  (28974) larva L2  (30945) larva L3 12hr old  (27009) larva L3 puffstage 1-2  (46324) larva L3 puffstage 3-6  (42748) larva L3 puffstage 7-9  (41999) white prepupae new  (41239) white prepupae 12hr  (31888) white prepupae 24hr  (29795) pupae 2d postWPP  (25740) pupae 3d postWPP  (17501) pupae 4d postWPP  (14305) adult male 01day  (31638) adult male 05day  (30159) adult male 30day  (28709) adult female 01day  (24858) adult female 05day  (25254) adult female 30day  (31949) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13932 embryo 02-04hr    21275 embryo 04-06hr    18543 embryo 06-08hr    15721 embryo 08-10hr    18692 embryo 10-12hr    17554 embryo 12-14hr    19977 embryo 14-16hr    16909 embryo 16-18hr    17067 embryo 18-20hr    19660 embryo 20-22hr    20030 embryo 22-24hr    22980 larva L1    28974 larva L2    30945 larva L3 12hr old    27009 larva L3 puffstage 1-2    46324 larva L3 puffstage 3-6    42748 larva L3 puffstage 7-9    41999 white prepupae new    41239 white prepupae 12hr    31888 white prepupae 24hr    29795 pupae 2d postWPP    25740 pupae 3d postWPP    17501 pupae 4d postWPP    14305 adult male 01day    31638 adult male 05day    30159 adult male 30day    28709 adult female 01day    24858 adult female 05day    25254 adult female 30day    31949 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015221 expression level Developmental Stage   Expression Level embryo 00-02hr    13932 embryo 02-04hr    21275 embryo 04-06hr    18543 embryo 06-08hr    15721 embryo 08-10hr    18692 embryo 10-12hr    17554 embryo 12-14hr    19977 embryo 14-16hr    16909 embryo 16-18hr    17067 embryo 18-20hr    19660 embryo 20-22hr    20030 embryo 22-24hr    22980 larva L1    28974 larva L2    30945 larva L3 12hr old    27009 larva L3 puffstage 1-2    46324 larva L3 puffstage 3-6    42748 larva L3 puffstage 7-9    41999 white prepupae new    41239 white prepupae 12hr    31888 white prepupae 24hr    29795 pupae 2d postWPP    25740 pupae 3d postWPP    17501 pupae 4d postWPP    14305 adult male 01day    31638 adult male 05day    30159 adult male 30day    28709 adult female 01day    24858 adult female 05day    25254 adult female 30day    31949 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13932) embryo 02-04hr  (21275) embryo 04-06hr  (18543) embryo 06-08hr  (15721) embryo 08-10hr  (18692) embryo 10-12hr  (17554) embryo 12-14hr  (19977) embryo 14-16hr  (16909) embryo 16-18hr  (17067) embryo 18-20hr  (19660) embryo 20-22hr  (20030) embryo 22-24hr  (22980) larva L1  (28974) larva L2  (30945) larva L3 12hr old  (27009) larva L3 puffstage 1-2  (46324) larva L3 puffstage 3-6  (42748) larva L3 puffstage 7-9  (41999) white prepupae new  (41239) white prepupae 12hr  (31888) white prepupae 24hr  (29795) pupae 2d postWPP  (25740) pupae 3d postWPP  (17501) pupae 4d postWPP  (14305) adult male 01day  (31638) adult male 05day  (30159) adult male 30day  (28709) adult female 01day  (24858) adult female 05day  (25254) adult female 30day  (31949) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13932) embryo 02-04hr  (21275) embryo 04-06hr  (18543) embryo 06-08hr  (15721) embryo 08-10hr  (18692) embryo 10-12hr  (17554) embryo 12-14hr  (19977) embryo 14-16hr  (16909) embryo 16-18hr  (17067) embryo 18-20hr  (19660) embryo 20-22hr  (20030) embryo 22-24hr  (22980) larva L1  (28974) larva L2  (30945) larva L3 12hr old  (27009) larva L3 puffstage 1-2  (46324) larva L3 puffstage 3-6  (42748) larva L3 puffstage 7-9  (41999) white prepupae new  (41239) white prepupae 12hr  (31888) white prepupae 24hr  (29795) pupae 2d postWPP  (25740) pupae 3d postWPP  (17501) pupae 4d postWPP  (14305) adult male 01day  (31638) adult male 05day  (30159) adult male 30day  (28709) adult female 01day  (24858) adult female 05day  (25254) adult female 30day  (31949) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  13932 embryo 02-04hr  (21275) embryo 04-06hr  18543 embryo 06-08hr  15721 embryo 08-10hr  18692 embryo 10-12hr  17554 embryo 12-14hr  19977 embryo 14-16hr  16909 embryo 16-18hr  17067 embryo 18-20hr  19660 embryo 20-22hr  20030 embryo 22-24hr  (22980) larva L1  (28974) larva L2  (30945) larva L3 12hr old  (27009) larva L3 puffstage 1-2  (46324) larva L3 puffstage 3-6  (42748) larva L3 puffstage 7-9  (41999) white prepupae new  (41239) white prepupae 12hr  (31888) white prepupae 24hr  (29795) pupae 2d postWPP  (25740) pupae 3d postWPP  17501 pupae 4d postWPP  14305 adult male 01day  (31638) adult male 05day  (30159) adult male 30day  (28709) adult female 01day  (24858) adult female 05day  (25254) adult female 30day  (31949) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13932 embryo 02-04hr    21275 embryo 04-06hr    18543 embryo 06-08hr    15721 embryo 08-10hr    18692 embryo 10-12hr    17554 embryo 12-14hr    19977 embryo 14-16hr    16909 embryo 16-18hr    17067 embryo 18-20hr    19660 embryo 20-22hr    20030 embryo 22-24hr    22980 larva L1    28974 larva L2    30945 larva L3 12hr old    27009 larva L3 puffstage 1-2    46324 larva L3 puffstage 3-6    42748 larva L3 puffstage 7-9    41999 white prepupae new    41239 white prepupae 12hr    31888 white prepupae 24hr    29795 pupae 2d postWPP    25740 pupae 3d postWPP    17501 pupae 4d postWPP    14305 adult male 01day    31638 adult male 05day    30159 adult male 30day    28709 adult female 01day    24858 adult female 05day    25254 adult female 30day    31949 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015221    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015221 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015221 expression level Tissue   Expression Level Larval Central Nervous System    1957.05 Larval Midgut    5224.9 Larval Hindgut    2234.7 Larval Malpighian Tubules    4048.4 Larval Fat Body    3266 Larval Salivary Gland    1535.3 Larval Trachea    2197.5 Larval Carcass    1681.95 Adult Head    3010.3 Adult Eye    4363.175 Adult Brain    2438.2 Adult Thoracic-Abdominal Ganglion    3016.5 Adult Crop    2310.3 Adult Midgut    5072.4 Adult Hindgut    2889.9 Adult Malpighian Tubules    4347.9 Adult Fat Body    4851.5 Adult Salivary Gland    3318.7 Adult Heart    6964.85 Adult VirginFemale Spermatheca    4927.5 Adult InseminatedFemale Spermatheca    4609.6 Adult Ovary    1411.5 Adult Testis    1177.4 Adult Male Accessory Gland    2434.1 Adult Carcass    4625.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1957.05) Larval Midgut  (5224.9) Larval Hindgut  (2234.7) Larval Malpighian Tubules  (4048.4) Larval Fat Body  (3266) Larval Salivary Gland  (1535.3) Larval Trachea  (2197.5) Larval Carcass  (1681.95) Adult Head  (3010.3) Adult Eye  (4363.175) Adult Brain  (2438.2) Adult Thoracic-Abdominal Ganglion  (3016.5) Adult Crop  (2310.3) Adult Midgut  (5072.4) Adult Hindgut  (2889.9) Adult Malpighian Tubules  (4347.9) Adult Fat Body  (4851.5) Adult Salivary Gland  (3318.7) Adult Heart  (6964.85) Adult VirginFemale Spermatheca  (4927.5) Adult InseminatedFemale Spermatheca  (4609.6) Adult Ovary  (1411.5) Adult Testis  (1177.4) Adult Male Accessory Gland  (2434.1) Adult Carcass  (4625.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1957.05) Larval Midgut  (5224.9) Larval Hindgut  (2234.7) Larval Malpighian Tubules  (4048.4) Larval Fat Body  (3266) Larval Salivary Gland  (1535.3) Larval Trachea  (2197.5) Larval Carcass  (1681.95) Adult Head  (3010.3) Adult Eye  (4363.175) Adult Brain  (2438.2) Adult Thoracic-Abdominal Ganglion  (3016.5) Adult Crop  (2310.3) Adult Midgut  (5072.4) Adult Hindgut  (2889.9) Adult Malpighian Tubules  (4347.9) Adult Fat Body  (4851.5) Adult Salivary Gland  (3318.7) Adult Heart  (6964.85) Adult VirginFemale Spermatheca  (4927.5) Adult InseminatedFemale Spermatheca  (4609.6) Adult Ovary  (1411.5) Adult Testis  (1177.4) Adult Male Accessory Gland  (2434.1) Adult Carcass  (4625.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1957.05 Larval Midgut    5224.9 Larval Hindgut    2234.7 Larval Malpighian Tubules    4048.4 Larval Fat Body    3266 Larval Salivary Gland    1535.3 Larval Trachea    2197.5 Larval Carcass    1681.95 Adult Head    3010.3 Adult Eye    4363.175 Adult Brain    2438.2 Adult Thoracic-Abdominal Ganglion    3016.5 Adult Crop    2310.3 Adult Midgut    5072.4 Adult Hindgut    2889.9 Adult Malpighian Tubules    4347.9 Adult Fat Body    4851.5 Adult Salivary Gland    3318.7 Adult Heart    6964.85 Adult VirginFemale Spermatheca    4927.5 Adult InseminatedFemale Spermatheca    4609.6 Adult Ovary    1411.5 Adult Testis    1177.4 Adult Male Accessory Gland    2434.1 Adult Carcass    4625.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015221 expression level Tissue   Expression Level Larval Central Nervous System    1957.05 Larval Midgut    5224.9 Larval Hindgut    2234.7 Larval Malpighian Tubules    4048.4 Larval Fat Body    3266 Larval Salivary Gland    1535.3 Larval Trachea    2197.5 Larval Carcass    1681.95 Adult Head    3010.3 Adult Eye    4363.175 Adult Brain    2438.2 Adult Thoracic-Abdominal Ganglion    3016.5 Adult Crop    2310.3 Adult Midgut    5072.4 Adult Hindgut    2889.9 Adult Malpighian Tubules    4347.9 Adult Fat Body    4851.5 Adult Salivary Gland    3318.7 Adult Heart    6964.85 Adult VirginFemale Spermatheca    4927.5 Adult InseminatedFemale Spermatheca    4609.6 Adult Ovary    1411.5 Adult Testis    1177.4 Adult Male Accessory Gland    2434.1 Adult Carcass    4625.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1957.05) Larval Midgut  (5224.9) Larval Hindgut  (2234.7) Larval Malpighian Tubules  (4048.4) Larval Fat Body  (3266) Larval Salivary Gland  (1535.3) Larval Trachea  (2197.5) Larval Carcass  (1681.95) Adult Head  (3010.3) Adult Eye  (4363.175) Adult Brain  (2438.2) Adult Thoracic-Abdominal Ganglion  (3016.5) Adult Crop  (2310.3) Adult Midgut  (5072.4) Adult Hindgut  (2889.9) Adult Malpighian Tubules  (4347.9) Adult Fat Body  (4851.5) Adult Salivary Gland  (3318.7) Adult Heart  (6964.85) Adult VirginFemale Spermatheca  (4927.5) Adult InseminatedFemale Spermatheca  (4609.6) Adult Ovary  (1411.5) Adult Testis  (1177.4) Adult Male Accessory Gland  (2434.1) Adult Carcass  (4625.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1957.05) Larval Midgut  (5224.9) Larval Hindgut  (2234.7) Larval Malpighian Tubules  (4048.4) Larval Fat Body  (3266) Larval Salivary Gland  1535.3 Larval Trachea  (2197.5) Larval Carcass  1681.95 Adult Head  (3010.3) Adult Eye  (4363.175) Adult Brain  (2438.2) Adult Thoracic-Abdominal Ganglion  (3016.5) Adult Crop  (2310.3) Adult Midgut  (5072.4) Adult Hindgut  (2889.9) Adult Malpighian Tubules  (4347.9) Adult Fat Body  (4851.5) Adult Salivary Gland  (3318.7) Adult Heart  (6964.85) Adult VirginFemale Spermatheca  (4927.5) Adult InseminatedFemale Spermatheca  (4609.6) Adult Ovary  1411.5 Adult Testis  1177.4 Adult Male Accessory Gland  (2434.1) Adult Carcass  (4625.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1957.05 Larval Midgut    5224.9 Larval Hindgut    2234.7 Larval Malpighian Tubules    4048.4 Larval Fat Body    3266 Larval Salivary Gland    1535.3 Larval Trachea    2197.5 Larval Carcass    1681.95 Adult Head    3010.3 Adult Eye    4363.175 Adult Brain    2438.2 Adult Thoracic-Abdominal Ganglion    3016.5 Adult Crop    2310.3 Adult Midgut    5072.4 Adult Hindgut    2889.9 Adult Malpighian Tubules    4347.9 Adult Fat Body    4851.5 Adult Salivary Gland    3318.7 Adult Heart    6964.85 Adult VirginFemale Spermatheca    4927.5 Adult InseminatedFemale Spermatheca    4609.6 Adult Ovary    1411.5 Adult Testis    1177.4 Adult Male Accessory Gland    2434.1 Adult Carcass    4625.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3010.3   NA  Eye    4363.175   NA  Brain    2438.2   1957.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3016.5   NA  Crop    2310.3   5224.9  Midgut    5072.4   2234.7  Hindgut    2889.9   4048.4  Malpighian Tubules    4347.9   3266  Fat Body    4851.5   1535.3  Salivary Gland    3318.7   NA  Heart    6964.85   2197.5  Trachea    NA   NA  VirginFemale Spermatheca    4927.5   NA  InseminatedFemale Spermatheca    4609.6   NA  Ovary    1411.5   NA  Testis    1177.4   NA  Male Accessory Gland    2434.1   1681.95  Carcass    4625.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015221 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1469-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Fer2LCH Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Fer2LCHCA07607 lethal | recessive Fer2LCH00035 Fer2LCH00823 Fer2LCH02545 Fer2LCH04050 Fer2LCH04095 Fer2LCH04244 Fer2LCH06701 Fer2LCH07078 Fer2LCHj2A3 Fer2LCHneo60 Fer2LCHneo63 Fer2LCHry46 Fer2LCHs2083 viable Fer2LCHEY10256 viable, with Scer\GAL4pnr-MD237 Fer2LCHGD6348 Sterility Allele fertile Fer2LCHEY10256 Other Phenotypes Allele circadian rhythm defective, with Scer\GAL4nrv2.PS Fer2LCHScer\UAS.cMa circadian rhythm defective, with Scer\GAL4repo Fer2LCHScer\UAS.cMa Phenotype manifest in Allele
Classical Alleles ( 40 )
For All Classical Alleles Show
Allele of Fer2LCH Class Mutagen Stocks Known lesion Fer2LCH00035 P-element activity 1 Yes Fer2LCH5-HA-1329 1 -- Fer2LCHc02854 piggyBac transposase 1 -- Fer2LCHd05207 P-element activity 1 -- Fer2LCHDG24702 1 -- Fer2LCHEY10256 P-element activity 1 -- Fer2LCHf06802 piggyBac transposase 1 -- Fer2LCHneo60 P-element activity 1 -- Fer2LCHNP2602 1 -- Fer2LCHNP4763 1 -- Fer2LCHNP6567 1 -- Fer2LCHNP6569 1 -- Fer2LCH00823 P-element activity 0 -- Fer2LCH02545 P-element activity 0 -- Fer2LCH04050 P-element activity 0 -- Fer2LCH04095 P-element activity 0 -- Fer2LCH04244 P-element activity 0 -- Fer2LCH06701 P-element activity 0 -- Fer2LCH07016 P-element activity 0 -- Fer2LCH07078 P-element activity 0 -- Fer2LCHc00587 piggyBac transposase 0 -- Fer2LCHc07178 piggyBac transposase 0 -- Fer2LCHCA07607 P-element activity 0 Yes Fer2LCHCB-5864-3 0 -- Fer2LCHCPTI100064 piggyBac transposase 0 Yes Fer2LCHd05102 P-element activity 0 -- Fer2LCHd09272 P-element activity 0 -- Fer2LCHd09276 P-element activity 0 -- Fer2LCHd10068 P-element activity 0 -- Fer2LCHd11531 P-element activity 0 -- Fer2LCHe01198 piggyBac transposase 0 -- Fer2LCHe03432 piggyBac transposase 0 -- Fer2LCHEP1038 P-element activity 0 -- Fer2LCHEP1059 0 -- Fer2LCHEP3356 P-element activity 0 -- Fer2LCHj2A3 P-element activity 0 -- Fer2LCHneo63 P-element activity 0 -- Fer2LCHry46 P-element activity 0 -- Fer2LCHs2083 P-element activity 0 -- Fer2LCHs2696b P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fer2LCH Class Mutagen Stocks Known lesion Fer2LCHGD6348 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fer2LCHKK103577 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fer2LCHScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Fer2LCHScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes Fer2LCHVDRC.cUa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC503 (Christensen et al., 2008.4.15) Df(3R)L127 (BDGP Project Members, 1994-1999) Df(3R)tll-g (Cook, 2006.1.31) T(Y;3)R133 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)tll-e (Cook, 2006.1.31) Df(3R)Tl-P (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6348} NA P{KK103577} NA P{UAS-Fer2LCH.M} NA P{UAS-Fer2LCH.R} NA characterization construct P{VDRC.Fer2LCH.U} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Fer2LCHEP1038 NA P{EP}Fer2LCHEP1059 NA P{EP}Fer2LCHEP3356 NA P{EPgy2}Fer2LCHEY10256 NA P{GSV1}532 NA P{GSV1}1287 NA P{GSV1}1472.2 NA P{GSV1}1652 NA P{GSV1}2484 NA P{GSV1}2521 NA P{GSV1}2703 NA P{GSV1}3102 NA P{GSV1}C328 NA P{XP}Fer2LCHd05102 NA P{XP}Fer2LCHd05207 NA P{XP}Fer2LCHd09272 NA P{XP}Fer2LCHd09276 NA P{XP}Fer2LCHd10068 NA P{XP}Fer2LCHd11531 NA miscellaneous insertions P{hsneo}Fer2LCHneo60 NA P{hsneo}Fer2LCHneo63 NA P{PTT-GA}Fer2LCHCA07607 NA P{RS3}Fer2LCHCB-5864-3 NA P{RS5}Fer2LCH5-HA-1329 NA P{ry11}Fer2LCHry46 NA P{wHy}Fer2LCHDG24702 NA PBac{544.SVS-1}Fer2LCHCPTI100064 NA PBac{PB}Fer2LCHc00587 NA PBac{PB}Fer2LCHc02854 NA PBac{PB}Fer2LCHc07178 NA PBac{RB}Fer2LCHe01198 NA PBac{RB}Fer2LCHe03432 NA PBac{WH}Fer1HCHf01674 NA PBac{WH}Fer1HCHf01958 NA PBac{WH}Fer2LCHf06802 NA insertion of enhancer trap binary system P{GawB}Fer2LCHNP2602 No P{GawB}Fer2LCHNP4763 No P{GawB}Fer2LCHNP6567 No P{GawB}Fer2LCHNP6569 No insertion of enhancer trap P{lacW}Fer2LCHj2A3 No P{lacW}Fer2LCHs2083 No P{lacW}Fer2LCHs2696b No P{PZ}Fer2LCH00035 No P{PZ}Fer2LCH00823 No P{PZ}Fer2LCH02545 No P{PZ}Fer2LCH04050 No P{PZ}Fer2LCH04095 No P{PZ}Fer2LCH04244 No P{PZ}Fer2LCH06701 No P{PZ}Fer2LCH07016 No P{PZ}Fer2LCH07078 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
ferrous iron binding inferred from direct assay (Georgieva et al., 1999)
Biological Process
CV term Evidence References
cellular iron ion homeostasis inferred from direct assay (Georgieva et al., 1999) chaeta development inferred from genetic interaction with Ssdp (Bronstein et al., 2010)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (Missirlis et al., 2007) intracellular ferritin complex inferred from direct assay (Georgieva et al., 1999)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ferric iron binding inferred from electronic annotation with InterPro:IPR001519, InterPro:IPR008331 (FlyBase Curators et al., 2004-) oxidoreductase activity inferred from electronic annotation with InterPro:IPR009078 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
iron ion transport inferred from electronic annotation with InterPro:IPR001519 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR009078 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fer2LCH allele Gene References Fer2LCH07016 Kr (Carrera et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69415 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015221 DroID - A comprehensive database of gene and protein interactions. • FBgn0015221 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44965
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18833 Dere\GG11747 Dgri\GH19160 Dmoj\GI23266 Dper\GL13455 Dpse\GA13179 Dsec\GM12876 Dsim\GD21514 Dvir\GJ10765 Dwil\GK14130 Dyak\GE10874
Curated drosophilid orthologs	Dpse\GA13179
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002158-PA Aedes aegypti (mosquito) AGAP002464-PA Anopheles gambiae (mosquito) XP_624076.1 Apis mellifera (honey bee) XP_001946769.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008780-PA Bombyx mori (silk worm) CPIJ004069 Culex pipens (mosquito) 305642 Daphnia pulex (daphnia) XP_001607354.1 Nasonia vitripennis (wasp) PHUM005570-PA Pediculus humanus (human body louse) XP_966312.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13010 LH18684 FBgn0228709 FBgn0216136 FBgn0198039 FBgn0192940 FBgn0167808 JGI_V11_290511 JGI_V11_305642 FBgn0073216 FBgn0151061 FBgn0145993 FBgn0126627 FBgn0104042 FBgn0095850 CPIJ004069 CPIJ008182 BGIBMGA008780 ACYPI007511 GB13223 AGAP002464 AAEL010396 AAEL007383 AAEL002158 PB23829 PHUM597350 GLEAN_01092
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	21358 y1 w67c23; P{EPgy2}Fer2LCHEY10256 11483 ry506 P{PZ}Fer2LCH00035/TM3, ryRK Sb1 Ser1
Harvard	- P{XP}Fer2LCHd05207 - PBac{PB}Fer2LCHc02854 - PBac{WH}Fer2LCHf06802
Kyoto	125195 w1118; P{RS5}Fer2LCH5-HA-1329 104255 w*; P{GawB}Fer2LCHNP2602 / TM3, Sb1 Ser1 113517 w*; P{GawB}Fer2LCHNP4763 / TM3, Sb1 Ser1 113984 y* w*; P{GawB}Fer2LCHNP6567 / TM6, P{UAS-lacZ.UW23-1}UW23-1 113985 y* w*; P{GawB}Fer2LCHNP6569 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v106960 P{KK103577}VIE-260B v14491 w1118; P{GD6348}v14491
	More stocks available...
Genomic Clones ( 1 )
	BACR22M06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 90 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT19513
Other clones	DPiM_AT19513
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07641 AT12713 AT16780 AT17651 AT20786 AT21070 AT23450 AT25782 AT30153 GM04412 GM04907 GM05883 GM08410 GM09409 LD01936 LD05571 LD10239 LD11001 LD22179 LP08855 LP18114 LP22484 LP23667 RE02825 RE16225 RE38464 RE38564
Other clones	13649 32951 42822 47325 50793 63441 78017 82618 147469 149166 157222 167147.2 167421 176844 275000 bs09d02 bs34g11 bs50e12 bs78f03 CK01.13D.C9 CK01.20A.D6 CK01.30A.F11 CK01.58B.F7 CK01.73C.H11 CK01.98D.A6 CK01.122D.A8 Dmel_dig_008454_0663_0878 Dmel_dig_010930_0690_2819 Dmel_dig_020568_0660_3231 Dmel_dig_021322_0632_3509 Dmel_neb_010762_0439_1994 Dmel_neb_012970_0102_0565 EC35923 EC40361 EC40685 EK040837 EK046924 EK054356 EK058030 EK093536 EK171628 EK171647 EK175431 EK211845 EK254743 EK260554 EK272221 EK277812 EK281663 ESG012b.TE.1_C10 ESG014c.E21_H07 ESG015c.E21_B02 ESG018c.E21.1_H11 ESG0113a.B21_C05 ESG0120b.B21_A08 IP13145 RC0-DA0003-130700-011-C12 RC0-DA0003-130700-011-H08 RC0-DA0003-130700-012-D12 UUGC0017 UUGC1101
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015221 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44965
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Fer2LCH anon-EST:ParkEST264 (Bayraktaroglu, 2000.11.2) Source for merge of: Fer2LCH CG1469 (Bayraktaroglu, 2000.4.12) Source for merge of: Fer2LCH l(3)00035 (Spradling et al., 1999) Source for merge of: Fer2LCH l(3)neo60 l(3)neo63 (Beaton, 1999.12.12)
Additional comments
Other Comments
	Encodes the 28kD ferritin subunit. (Georgieva et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080063 NM_170483 NM_170484 RefSeq (Proteins) • NP_524802 NP_733362 NP_733363 DDBJ / EMBL / GenBank • AA391342 AA696012 AA696792 AAF07876 AAF07879 AAF57038 AAL48427 AAN14228 AAN14229 AF145124 AF145126 AI467773 AI945133 AI947080 AQ025156 AQ026351 AQ026352 AQ073305 AQ073940 AY070805 BF485589 CW848173 CZ466577 CZ468262 CZ468263 CZ471311 CZ474320 CZ474386 CZ474387 CZ476651 CZ476652 CZ476654 CZ477084 CZ477790 CZ479007 CZ481207 CZ489532 Entrez Gene - A searchable database of RefSeq genes. • 44965 UniProtKB/TrEMBL • Q9U4U2 Q9U7A3 Q9VA83
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ferritin/DPS protein domain (IPR008331) Ferritin-like (IPR009040) Ferritin/ribonucleotide reductase-like (IPR009078) Ferritin-related (IPR012347) Ferritin (IPR001519)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69415 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015221 DroID - A comprehensive database of gene and protein interactions. • FBgn0015221 DRSC - Results from RNAi screens. • FBgn0015221 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015221 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1469-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015221 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44965 InParanoid A subset of ortholog calls from InParanoid. • AAEL002158-PA Aedes aegypti (mosquito) AGAP002464-PA Anopheles gambiae (mosquito) XP_624076.1 Apis mellifera (honey bee) XP_001946769.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008780-PA Bombyx mori (silk worm) CPIJ004069 Culex pipens (mosquito) 305642 Daphnia pulex (daphnia) XP_001607354.1 Nasonia vitripennis (wasp) PHUM005570-PA Pediculus humanus (human body louse) XP_966312.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/ferritin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44965 modMine - Data generated by the modENCODE project. • FBgn0015221 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13010 LH18684 FBgn0228709 FBgn0216136 FBgn0198039 FBgn0192940 FBgn0167808 JGI_V11_290511 JGI_V11_305642 FBgn0073216 FBgn0151061 FBgn0145993 FBgn0126627 FBgn0104042 FBgn0095850 CPIJ004069 CPIJ008182 BGIBMGA008780 ACYPI007511 GB13223 AGAP002464 AAEL010396 AAEL007383 AAEL002158 PB23829 PHUM597350 GLEAN_01092
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	2LCH (Georgieva et al., 2002) anon-EST:ParkEST264   CG1469 (Karlsson et al., 2004, Vierstraete et al., 2003, Molnar et al., 2006, Rival et al., 2009, Keleman et al., 2009.8.5, Shibata et al., 2010, Bronstein et al., 2010, Reumer et al., 2009, Cammarato et al., 2011) Fer2LC (Rival et al., 2009) Fer2LCH (Gruenewald et al., 2009, Buszczak et al., 2007, Dunkov and Georgieva, 2006, Arancio et al., 2010, Christensen et al., 2008.4.15, Molnar et al., 2006, Yepiskoposyan et al., 2006, Missirlis et al., 2007, FlyBase Curators, 2008, Kosmidis et al., 2011, Metzendorf et al., 2009, Metzendorf and Lind, 2010, Bronstein et al., 2010, Reumer et al., 2009) fer2lch (Mendes et al., 2009) Fer-H   FerLCH (Liu et al., 2011) l(3)00035 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(3)07016 (Carrera et al., 1998) l(3)j2A3   l(3)neo60 (Gonzalez-Reyes, 1995.8.1, BDGP Project Members, 1994-1999, Cooley et al., 1988, ) l(3)neo63 (BDGP Project Members, 1994-1999, Berg and Spradling, 1991, Cooley et al., 1988, ) l(3)s2083   LCH (Kosmidis et al., 2004) unnamed (Dunkov et al., 1997)
Name Synonym	Ferritin (Lind and Soderhall, 1998) ferritin (Sadraie and Missirlis, 2011) Ferritin 2 light chain (Shibata et al., 2010) ferritin 2 light chain (Rival et al., 2009) Ferritin 2 light chain homologue (Reumer et al., 2009, Cammarato et al., 2011) Ferritin-Heavy   Ferritin-Light (Georgieva et al., 1995) ferritin light chain (Liu et al., 2011)
Secondary FlyBase IDs
	FBgn0010705 FBgn0011018 FBgn0011321 FBgn0011490 FBgn0011491 FBgn0026287 FBgn0039763
References ( 64 )
Generate a list of	All references relating to this gene ( 64 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Kosmidis et al., 2011, Neurobiol. Disease 43(1): 213--219 Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. [FBrf0213691] Liu et al., 2011, J. Biol. Chem. 286(6): 4248--4256 Iron Promotes the Toxicity of Amyloid {beta} Peptide by Impeding Its Ordered Aggregation. [FBrf0212930] Sadraie and Missirlis, 2011, Biometals 24(4): 679--686 Evidence for evolutionary constraints in Drosophila metal biology. [FBrf0214363] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Bronstein et al., 2010, PLoS Genet. 6(8): e1001063 Transcriptional regulation by CHIP/LDB complexes. [FBrf0211594] Metzendorf and Lind, 2010, BMC Dev. Biol. 10: 68 Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. [FBrf0211300] Robinson et al., 2010, Mech. Ageing Dev. 131(9): 584--590 Insights into aging through measurements of the Drosophila proteome as a function of temperature. [FBrf0211959] Shibata et al., 2010, PLoS ONE 5(10): e13477 Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila. [FBrf0212149] Show all research papers ...