lectin (carbohydrate binding protein) - regulates cell adhesion in midline glia - enriched in Golgi bodies - a positive regulator of Notch signalling during wing development
Please see the JBrowse view of Dmel\glec for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
1.7 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
228 (aa); 46.6 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\glec using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
glec transcript is expressed in cells immediately dorsal to and ventral to the dorsal/ventral compartment boundary of the wing disc. No expression is observed in the haltere disc.
Expression pattern inferred from unspecified enhancer trap line.
On Northern blots, the glec transcript is detected at highest levels in embryos, at low levels in larvae and pupae, and at extremely low levels in adult flies. Using in situ localization, the glec transcript is first detected at stage 11 of embryogenesis, in a segmentally repeated pattern in the ectoderm. This expression peaks at stages 13-14 in midline cells within the ventral nerve cord.
In stage 12-13 embryos, glec protein is detectable in midline glial cells along the anterior commissure. The midline glial cells anterior to the anterior commissure are stained at stages 14-15.
JBrowse - Visual display of RNA-Seq signals
View Dmel\glec in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
A subset of COS cells transfected with an embryonic cDNA library adhere to zwitterionic glycolipids isolated from embryos. Analysis of the encoded proteins expression pattern and carbohydrate-binding activity led to the protein designation 'Gliolectin'.
