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Gene Dmel\Hr78

General Information
Symbol	Dmel\Hr78	Species	D. melanogaster
Name	Hormone-receptor-like in 78	Annotation symbol	CG7199
Feature type	protein_coding_gene	FlyBase ID	FBgn0015239
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	DHR78, XR78E/F, NR2D1
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	78D4-78D4	Sequence location	3L:21,487,119..21,490,585 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Hormone-receptor-like in 78 is referred to in FlyBase by the symbol Dmel\Hr78 (CG7199, FBgn0015239). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding; ligand-dependent nuclear receptor activity. There is experimental evidence that it is involved in the biological process: autophagic cell death; liquid clearance, open tracheal system; open tracheal system development; salivary gland cell autophagic cell death; neurogenesis. 14 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; embryonic/larval trachea; embryonic/larval tracheal system; mesothoracic tergum. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Nuclear hormone receptor, ligand-binding; Nuclear hormone receptor, ligand-binding, core; Steroid hormone receptor; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval fat body, larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634150_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Hr78. Gene sequence location is 3L:21487119..21490585.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	References Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700 Thomsen et al., 2010, Genome Biol. 11(9): R93 Sequence features HFA11866 BKN28408 Controlled Vocabulary Terms RNA polymerase II regulatory region sequence-specific DNA binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78D4-78D4   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 78D4-78D4     (Fisk, 1995.9.20) 78D4-78D5   (determined by in situ hybridisation)   (Fisk and Thummel, 1995)
Experimentally Determined Recombination Data
Location	3- (Fisk, 1995.9.20)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hr78 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hr78-RA FBtr0078391  NM_079479   2330   599 Hr78-RB FBtr0078389  NM_168907   2257   601 Hr78-RC FBtr0078390  NM_168908   2302   601 Hr78-RD FBtr0078392  NM_206415   2336   601 Hr78-RE FBtr0303653  NM_001202222   2182   601 Hr78-RF FBtr0303654  NM_001202223   2175   601
Additional Transcript Data & Comments
Reported size (kB)	2.3 (northern blot) (Fisk and Thummel, 1995) 2.3 (longest cDNA) (Zelhof et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hr78-PA   FBpp0078046   65.2   599   6.20     NP_524203   AAF51731 Hr78-PB   FBpp0078044   65.4   601   6.09     NP_730636   AAN12168 Hr78-PC   FBpp0078045   65.4   601   6.09     NP_730637   AAN12169 Hr78-PD   FBpp0089291   65.4   601   6.09     NP_996137   AAS65089 Hr78-PE   FBpp0292670   65.4   601   6.09     NP_001189151   ADV37587 Hr78-PF   FBpp0292671   65.4   601   6.09     NP_001189152   ADV37588
Additional Polypeptide Data & Comments
Reported size (kDa)	601 (aa) (Zelhof et al., 1995, Fisk and Thummel, 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nuclear hormone receptor, ligand-binding, core (IPR000536) Zinc finger, nuclear hormone receptor-type (IPR001628) Steroid hormone receptor (IPR001723) Zinc finger, NHR/GATA-type (IPR013088) Nuclear hormone receptor, ligand-binding (IPR008946)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141744   AA141811   AA247037   AA392683   AE014296 AAF51731   AE014296 AAN12168   AE014296 AAN12169   AE014296 AAS65089   AE014296 ADV37587   AE014296 ADV37588   AI108800   AI135176   AI259330   AI297096   AI402117   AI511666   AI516429   AI520424   AI542682   AY058317 AAL13546   BE977161   BF486160   BF487361   BF490463   BF492656   BF492657   BF496277   BF497498   BF497838   BF497927   BF500627   BF505401   BF506418   BF506619   BG633891   BG634720   BI142242   BI487075   BI567745   BI567755   BI574542   BI577809   BI579613   BI579836   BI579922   BI604912   BI612441   BI612615   BI619628   BI621215   BI623208   BI625217   BI634076   BI634231   BI635588   BI637191   BT030409   BT125882   CA804322   CK660004   CO194439   CO300795   CO305132   CO311033   CO313398   CO324378   EC062484   EC066576   EC202689   EC226190   EC240273   EC246708   EC248972   EC265219   EV574771   GH944993   GH953990   GH958142   GH961143   GH973872   GH979418   GH979465   GH982680   U31517 AAC46924   U36791 AAC46927
UniProtKB/Swiss-Prot	Q24142
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Zelhof et al., 1995) embryonic stage & larval stage & prepupal stage     (Zelhof et al., 1995) larval stage   embryonic/larval salivary gland   (Zelhof et al., 1995) larval stage & prepupal stage     (Fisk and Thummel, 1995)
Additional Descriptive Data
	Hr78 transcripts are expressed at low levels in embryos and early larvae and increase after the 2nd to 3rd instar molt. Expression does not appear to be strongly activated by ecdysone. They are expressed ubiquitously in embryos and imaginal discs at low levels. (Zelhof et al., 1995) Hr78 is expressed throughout third instar larval and prepupal development. A distinct increase in levels is seen at 106hr after egg laying suggesting that it may be ecdysone-inducible. Hr78 transcripts were shown to be ecdysone inducible in cultured larval organs. (Fisk and Thummel, 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015239    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015239 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015239 expression level Developmental Stage   Expression Level embryo 00-02hr    3092 embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr    1438 embryo 08-10hr    2688 embryo 10-12hr    3456 embryo 12-14hr    2960 embryo 14-16hr    2128 embryo 16-18hr    2030 embryo 18-20hr    2520 embryo 20-22hr    1881 embryo 22-24hr    1864 larva L1    1597 larva L2    1440 larva L3 12hr old    1483 larva L3 puffstage 1-2    1803 larva L3 puffstage 3-6    2996 larva L3 puffstage 7-9    3732 white prepupae new    3359 white prepupae 12hr    3293 white prepupae 24hr    3996 pupae 2d postWPP    2792 pupae 3d postWPP    1676 pupae 4d postWPP    1465 adult male 01day    1377 adult male 05day    1472 adult male 30day    1353 adult female 01day    1879 adult female 05day    2510 adult female 30day    2542 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3092) embryo 02-04hr  (414) embryo 04-06hr  (270) embryo 06-08hr  (1438) embryo 08-10hr  (2688) embryo 10-12hr  (3456) embryo 12-14hr  (2960) embryo 14-16hr  (2128) embryo 16-18hr  (2030) embryo 18-20hr  (2520) embryo 20-22hr  (1881) embryo 22-24hr  (1864) larva L1  (1597) larva L2  (1440) larva L3 12hr old  (1483) larva L3 puffstage 1-2  (1803) larva L3 puffstage 3-6  (2996) larva L3 puffstage 7-9  (3732) white prepupae new  (3359) white prepupae 12hr  (3293) white prepupae 24hr  (3996) pupae 2d postWPP  (2792) pupae 3d postWPP  (1676) pupae 4d postWPP  (1465) adult male 01day  (1377) adult male 05day  (1472) adult male 30day  (1353) adult female 01day  (1879) adult female 05day  (2510) adult female 30day  (2542) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3092) embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr  1438 embryo 08-10hr  (2688) embryo 10-12hr  (3456) embryo 12-14hr  (2960) embryo 14-16hr  (2128) embryo 16-18hr  (2030) embryo 18-20hr  (2520) embryo 20-22hr  (1881) embryo 22-24hr  (1864) larva L1  (1597) larva L2  1440 larva L3 12hr old  1483 larva L3 puffstage 1-2  (1803) larva L3 puffstage 3-6  (2996) larva L3 puffstage 7-9  (3732) white prepupae new  (3359) white prepupae 12hr  (3293) white prepupae 24hr  (3996) pupae 2d postWPP  (2792) pupae 3d postWPP  (1676) pupae 4d postWPP  1465 adult male 01day    1377 adult male 05day  1472 adult male 30day    1353 adult female 01day  (1879) adult female 05day  (2510) adult female 30day  (2542) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3092 embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr    1438 embryo 08-10hr    2688 embryo 10-12hr    3456 embryo 12-14hr    2960 embryo 14-16hr    2128 embryo 16-18hr    2030 embryo 18-20hr    2520 embryo 20-22hr    1881 embryo 22-24hr    1864 larva L1    1597 larva L2    1440 larva L3 12hr old    1483 larva L3 puffstage 1-2    1803 larva L3 puffstage 3-6    2996 larva L3 puffstage 7-9    3732 white prepupae new    3359 white prepupae 12hr    3293 white prepupae 24hr    3996 pupae 2d postWPP    2792 pupae 3d postWPP    1676 pupae 4d postWPP    1465 adult male 01day    1377 adult male 05day    1472 adult male 30day    1353 adult female 01day    1879 adult female 05day    2510 adult female 30day    2542 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3092 embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr    1438 embryo 08-10hr    2688 embryo 10-12hr    3456 embryo 12-14hr    2960 embryo 14-16hr    2128 embryo 16-18hr    2030 embryo 18-20hr    2520 embryo 20-22hr    1881 embryo 22-24hr    1864 larva L1    1597 larva L2    1440 larva L3 12hr old    1483 larva L3 puffstage 1-2    1803 larva L3 puffstage 3-6    2996 larva L3 puffstage 7-9    3732 white prepupae new    3359 white prepupae 12hr    3293 white prepupae 24hr    3996 pupae 2d postWPP    2792 pupae 3d postWPP    1676 pupae 4d postWPP    1465 adult male 01day    1377 adult male 05day    1472 adult male 30day    1353 adult female 01day    1879 adult female 05day    2510 adult female 30day    2542 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015239 expression level Developmental Stage   Expression Level embryo 00-02hr    3092 embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr    1438 embryo 08-10hr    2688 embryo 10-12hr    3456 embryo 12-14hr    2960 embryo 14-16hr    2128 embryo 16-18hr    2030 embryo 18-20hr    2520 embryo 20-22hr    1881 embryo 22-24hr    1864 larva L1    1597 larva L2    1440 larva L3 12hr old    1483 larva L3 puffstage 1-2    1803 larva L3 puffstage 3-6    2996 larva L3 puffstage 7-9    3732 white prepupae new    3359 white prepupae 12hr    3293 white prepupae 24hr    3996 pupae 2d postWPP    2792 pupae 3d postWPP    1676 pupae 4d postWPP    1465 adult male 01day    1377 adult male 05day    1472 adult male 30day    1353 adult female 01day    1879 adult female 05day    2510 adult female 30day    2542 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3092) embryo 02-04hr  (414) embryo 04-06hr  (270) embryo 06-08hr  (1438) embryo 08-10hr  (2688) embryo 10-12hr  (3456) embryo 12-14hr  (2960) embryo 14-16hr  (2128) embryo 16-18hr  (2030) embryo 18-20hr  (2520) embryo 20-22hr  (1881) embryo 22-24hr  (1864) larva L1  (1597) larva L2  (1440) larva L3 12hr old  (1483) larva L3 puffstage 1-2  (1803) larva L3 puffstage 3-6  (2996) larva L3 puffstage 7-9  (3732) white prepupae new  (3359) white prepupae 12hr  (3293) white prepupae 24hr  (3996) pupae 2d postWPP  (2792) pupae 3d postWPP  (1676) pupae 4d postWPP  (1465) adult male 01day  (1377) adult male 05day  (1472) adult male 30day  (1353) adult female 01day  (1879) adult female 05day  (2510) adult female 30day  (2542) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3092) embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr  1438 embryo 08-10hr  (2688) embryo 10-12hr  (3456) embryo 12-14hr  (2960) embryo 14-16hr  2128 embryo 16-18hr  2030 embryo 18-20hr  (2520) embryo 20-22hr  1881 embryo 22-24hr  1864 larva L1  1597 larva L2  1440 larva L3 12hr old  1483 larva L3 puffstage 1-2  1803 larva L3 puffstage 3-6  (2996) larva L3 puffstage 7-9  (3732) white prepupae new  (3359) white prepupae 12hr  (3293) white prepupae 24hr  (3996) pupae 2d postWPP  (2792) pupae 3d postWPP  1676 pupae 4d postWPP  1465 adult male 01day    1377 adult male 05day  1472 adult male 30day    1353 adult female 01day  1879 adult female 05day  (2510) adult female 30day  (2542) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3092 embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr    1438 embryo 08-10hr    2688 embryo 10-12hr    3456 embryo 12-14hr    2960 embryo 14-16hr    2128 embryo 16-18hr    2030 embryo 18-20hr    2520 embryo 20-22hr    1881 embryo 22-24hr    1864 larva L1    1597 larva L2    1440 larva L3 12hr old    1483 larva L3 puffstage 1-2    1803 larva L3 puffstage 3-6    2996 larva L3 puffstage 7-9    3732 white prepupae new    3359 white prepupae 12hr    3293 white prepupae 24hr    3996 pupae 2d postWPP    2792 pupae 3d postWPP    1676 pupae 4d postWPP    1465 adult male 01day    1377 adult male 05day    1472 adult male 30day    1353 adult female 01day    1879 adult female 05day    2510 adult female 30day    2542 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3092 embryo 02-04hr    414 embryo 04-06hr    270 embryo 06-08hr    1438 embryo 08-10hr    2688 embryo 10-12hr    3456 embryo 12-14hr    2960 embryo 14-16hr    2128 embryo 16-18hr    2030 embryo 18-20hr    2520 embryo 20-22hr    1881 embryo 22-24hr    1864 larva L1    1597 larva L2    1440 larva L3 12hr old    1483 larva L3 puffstage 1-2    1803 larva L3 puffstage 3-6    2996 larva L3 puffstage 7-9    3732 white prepupae new    3359 white prepupae 12hr    3293 white prepupae 24hr    3996 pupae 2d postWPP    2792 pupae 3d postWPP    1676 pupae 4d postWPP    1465 adult male 01day    1377 adult male 05day    1472 adult male 30day    1353 adult female 01day    1879 adult female 05day    2510 adult female 30day    2542 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015239    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015239 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval fat body, larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015239 expression level Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body    502.6 Larval Salivary Gland    1097.6 Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body  502.6 Larval Salivary Gland  (1097.6) Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body    502.6 Larval Salivary Gland  (1097.6) Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body    502.6 Larval Salivary Gland    1097.6 Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015239 expression level Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body    502.6 Larval Salivary Gland    1097.6 Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body  502.6 Larval Salivary Gland  (1097.6) Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body    502.6 Larval Salivary Gland  1097.6 Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    163.925 Larval Midgut    206.3 Larval Hindgut    321.3 Larval Malpighian Tubules    352.5 Larval Fat Body    502.6 Larval Salivary Gland    1097.6 Larval Trachea    424.225 Larval Carcass    470.275 Adult Head    175.6 Adult Eye    161.975 Adult Brain    173.7 Adult Thoracic-Abdominal Ganglion    193.3 Adult Crop    350 Adult Midgut    197.8 Adult Hindgut    302.3 Adult Malpighian Tubules    331.9 Adult Fat Body    211.7 Adult Salivary Gland    484.4 Adult Heart    166.35 Adult VirginFemale Spermatheca    389 Adult InseminatedFemale Spermatheca    311.6 Adult Ovary    380.3 Adult Testis    108.2 Adult Male Accessory Gland    484.2 Adult Carcass    250.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    175.6   NA  Eye    161.975   NA  Brain    173.7   163.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    193.3   NA  Crop    350   206.3  Midgut    197.8   321.3  Hindgut    302.3   352.5  Malpighian Tubules    331.9   502.6  Fat Body    211.7   1097.6  Salivary Gland    484.4   NA  Heart    166.35   424.225  Trachea    NA   NA  VirginFemale Spermatheca    389   NA  InseminatedFemale Spermatheca    311.6   NA  Ovary    380.3   NA  Testis    108.2   NA  Male Accessory Gland    484.2   470.275  Carcass    250.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015239 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7199-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Hr78 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Hr78GD1465 lethal | larval stage (with Df(3L)79-2) Hr782 Hr783 lethal | larval stage | recessive Hr781 Hr782 Hr783 lethal | pupal stage, with Scer\GAL4pnr-MD237 Hr78GD1465 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Hr78GD1465 viable, with Scer\GAL4pnr-MD237 Hr78GD16954 Sterility Allele female semi-sterile | maternal effect Hr782 Hr783 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Hr78GD1465 neuroanatomy defective | larval stage, with Scer\GAL41407 Hr78GD1465 visible, with Scer\GAL4pnr-MD237 Hr78GD1465 wild-type Hr78hs.PF Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Hr78GD1465 embryonic/larval trachea, with Scer\GAL4btl.PS Hr78dsRNA.Scer\UAS embryonic/larval trachea, with Scer\GAL4da.G32 Hr78dsRNA.Scer\UAS embryonic/larval trachea (with Df(3L)79-2) Hr782 Hr783 embryonic/larval tracheal system Hr781 Hr782 Hr783 ganglion mother cell | larval stage, with Scer\GAL41407 Hr78GD1465 mesothoracic tergum, with Scer\GAL4pnr-MD237 Hr78GD1465 trichogen cell, with Scer\GAL4pnr-MD237 Hr78GD1465
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Hr78 Class Mutagen Stocks Known lesion Hr782 amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes Hr78G6746 P-element activity 1 -- Hr781 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Hr783 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hr78 Class Mutagen Stocks Known lesion Hr78GD1465 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hr78GD16954 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hr78hs.T:Scer\GAL4.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Hr78JF03424 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hr78Act5C.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hr78dsRNA.Scer\UAS in vitro construct - RNAi 0 Yes Hr78hs.PF in vitro construct - regulatory fusion 0 Yes Hr78hs.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hr78KK108408 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Hr78Scer\UAS.Fa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)10-2 (Fisk and Thummel, 1998) Df(3L)79-2 (Fisk and Thummel, 1998) Df(3L)BSC418 (Christensen et al., 2008.4.15) Df(3L)BSC435 (Christensen et al., 2008.4.15) Df(3L)XS1155 (Fisk and Thummel, 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1465} NA P{GD16954} NA P{KK108408} NA P{TRiP.JF03424} NA P{UAS-Hr78.dsRNA} NA P{UAS-Hr78.F} NA heat-shock construct P{hs-GAL4-DHR78.LBD.HA} NA P{hs-GAL4-Hr78} NA P{hs-Hr78.F} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Y553 No insertion of mobile activating element P{EP}Hr78G6746 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
ligand-dependent nuclear receptor activity inferred from direct assay (Fisk and Thummel, 1998) RNA polymerase II regulatory region sequence-specific DNA binding inferred from direct assay (Fisk and Thummel, 1995)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) liquid clearance, open tracheal system inferred from mutant phenotype (Astle et al., 2003) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) open tracheal system development inferred from mutant phenotype (Astle et al., 2003) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Fisk and Thummel, 1998)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) traceable author statement (Lafont, 2000) ligand-dependent nuclear receptor activity inferred from sequence or structural similarity with EMBL:U32939 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1, Maglich et al., 2001) traceable author statement (Gibson and Schubiger, 2001) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:U32939 (FlyBase, 1992-) steroid hormone receptor activity inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR001723, InterPro:IPR008946 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR001628, InterPro:IPR001723, InterPro:IPR008946, InterPro:IPR013088 (FlyBase Curators et al., 2004-) steroid hormone mediated signaling pathway inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR008946 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:U32939 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hr78 allele Gene References unspecified Samuel (Baker et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65625 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015239 DroID - A comprehensive database of gene and protein interactions. • FBgn0015239 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40378
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10710 Dere\GG13230 Dgri\GH16822 Dmoj\GI11915 Dper\GL12781 Dpse\GA20175 Dsec\GM22136 Dsim\GD12114 Dvir\GJ13789 Dwil\GK25684 Dyak\GE22327
Curated drosophilid orthologs	Dpse\GA20175
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001796-PA Aedes aegypti (mosquito) AGAP008382-PA Anopheles gambiae (mosquito) XP_392769.3 Apis mellifera (honey bee) XP_001948311.1 Acyrthosiphon pisum (pea aphid) 129718 Branchiostoma floridae (lancelet) 56643 Branchiostoma floridae (lancelet) BGIBMGA013363-PA Bombyx mori (silk worm) ENSBTAP00000018228 Bos taurus (bovine) CN04944 Caenorhabditis brenneri (small nematode) CE37054 Caenorhabditis elegans (worm) ENSCAFP00000006818 Canis familiaris (dog) ENSCINP00000003290 Ciona intestinalis (sea squirt) CPIJ001878 Culex pipens (mosquito) ENSCPOP00000001367 Cavia porcellus (guinea pig) RP03708 Caenorhabditis remanei (nematode) ENSCSAVP00000014812 Ciona savignyi (sedentary tunicate) 224222 Capitella spl (polychaete worm) 323993 Daphnia pulex (daphnia) ENSDARP00000066947 Danio rerio (zebra fish) ENSECAP00000003935 Equus caballus (horse) ENSGACP00000003869 Gymnopilus aculeatus (mushroom) ENSGALP00000013858 Gallus gallus (chicken) 92366 Hypsipyla robusta (cedar shoot borer) ENSP00000320447 Homo sapiens (human) ISCW010278-PA Ixodes scapularis (deer tick) ENSMODP00000008737 Monodelphis domestica (gray opossum) ENSMMUP00000006824 Macaca mulatta (rhesus monkey) ENSMUSP00000109090 Mus musculus (house mouse) ENSOANP00000017249 Ornithorynchus anatinus (platypus) ENSORLP00000013643 Oryzias latipes (japanese killifish) PP18052 Pristionchus pacificus (nematode) ENSPPYP00000014996 Pongo pygmaeus (orangutan) ENSPTRP00000009016 Pan troglodytes (chimpanzee) ENSRNOP00000014354 Rattus norvegicus (norway rat) Smp_105090 Schistosoma mansoni (trematode parasite) XP_001195281.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001813130.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021080 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029267 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000051399 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17347 NV16686 LH16476 ISCW010278 FBgn0240168 FBgn0239550 FBgn0227643 FBgn0201008 FBgn0183851 FBgn0177007 JGI_V11_323993 FBgn0080170 FBgn0150387 FBgn0134673 FBgn0124293 FBgn0105502 FBgn0087751 CPIJ001878 BGIBMGA013363 ACYPI004234 GB18358 AGAP008382 AAEL001796 PHUM301950 GLEAN_04598
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	28860 w*; P{hs-GAL4-DHR78.LBD.HA}60.1.50 31990 y1 v1; P{TRiP.JF03424}attP2 4436 w*; Hr782/TM6B, Tb1 27214 y1 w*; P{EP}Hr78G6746
Kyoto	107746 w*; Hr782/TM6B, Tb1
VDRC	v37072 w1118; P{GD1465}v37072 v37073 w1118; P{GD1465}v37073 v48979 w1118; P{GD16954}v48979 v48978 w1118; P{GD16954}v48978/TM3
Genomic Clones ( 2 )
	BACR03O18 BACR26P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 75 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13850 GH08073
Other clones	DPiM_GH08073 IP07432
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07622 AT08877 AT09148 AT10039 AT11678 AT12139 AT12250 AT15618 AT20368 AT22134 AT26936 AT29853 AT31031 GH12830 LD06172 LD11460 LD40580 LD42292 LD43145 LP02722 LP11304 LP18208 RE70580 RE71560 RE73674 RE73926 RE74030 RH24471 RH37283 RH37664 RH38315 RH38331 RH41312 RH41548 RH50703 RH52524 RH55305 RH65509 RH70414 SD09121 SD16978 SD19135
Other clones	54385 65735 107014 121339 125563 162756 569446 AT01120 bs60e02 CK01.1D.A4 CK02430 CK02495 Dmel_dig_006135_0710_1957 EC38572 EK179424 EK193418 EK223207 EK232527 EK247516 ESG0113a.B21_E12 RP004041671 RP004120813 RP004218233 RP004237077 RP004250134 RP004250347 RP004374028 RP004537974 SD16290
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015239 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40378
Antibody Information
	polyclonal (Zelhof et al., 1995)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "e03593" Exelixis line (PBac{RB}CG33214e03593) was originally assigned to the Hr78 gene in FBrf0179797, resulting in the "Hr78e03593" (FBal0160320) allele. However, FBrf0184340 shows that the insertion is actually within CG33214. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	Hr78 protein is an obligate partner for Samuel protein, a cofactor that requires Hr78 protein for its stability. (Baker et al., 2007) Hr78 is not required for morphogenetic furrow formation in the developing eye. (Brennan et al., 2001) Hr78 functions at the top of the ecdysteroid regulatory hierarchies. Results propose that Hr78 is a ligand-activated receptor that plays a central role in directing the onset of metamorphosis. (Fisk and Thummel, 1998) Null mutations lead to lethality during the third larval instar with defects in ecdysteroid-triggered developmental responses. Mutants fail to activate the mid-third instar regulatory hierarchy that prepares the fly for metamorphosis. (Fisk and Thummel, 1998) Hr78 may play a regulatory role in the transcriptional cascade triggered by the hormone ecdysone. (Zelhof et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079479 NM_168907 NM_168908 NM_206415 NM_001202222 NM_001202223 RefSeq (Proteins) • NP_524203 NP_730636 NP_730637 NP_996137 NP_001189151 NP_001189152 DDBJ / EMBL / GenBank • AAC46924 AAC46927 AAF51731 AAL13546 AAN12168 AAN12169 AAS65089 ADV37587 ADV37588 AI108800 AI402117 AY058317 U31517 U36791 Entrez Gene - A searchable database of RefSeq genes. • 40378 UniProtKB/Swiss-Prot • Q24142
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nuclear hormone receptor, ligand-binding, core (IPR000536) Zinc finger, nuclear hormone receptor-type (IPR001628) Steroid hormone receptor (IPR001723) Zinc finger, NHR/GATA-type (IPR013088) Nuclear hormone receptor, ligand-binding (IPR008946)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65625 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015239 DroID - A comprehensive database of gene and protein interactions. • FBgn0015239 DRSC - Results from RNAi screens. • FBgn0015239 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015239 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7199-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015239 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40378 InParanoid A subset of ortholog calls from InParanoid. • AAEL001796-PA Aedes aegypti (mosquito) AGAP008382-PA Anopheles gambiae (mosquito) XP_392769.3 Apis mellifera (honey bee) XP_001948311.1 Acyrthosiphon pisum (pea aphid) 129718 Branchiostoma floridae (lancelet) 56643 Branchiostoma floridae (lancelet) BGIBMGA013363-PA Bombyx mori (silk worm) ENSBTAP00000018228 Bos taurus (bovine) CN04944 Caenorhabditis brenneri (small nematode) CE37054 Caenorhabditis elegans (worm) ENSCAFP00000006818 Canis familiaris (dog) ENSCINP00000003290 Ciona intestinalis (sea squirt) CPIJ001878 Culex pipens (mosquito) ENSCPOP00000001367 Cavia porcellus (guinea pig) RP03708 Caenorhabditis remanei (nematode) ENSCSAVP00000014812 Ciona savignyi (sedentary tunicate) 224222 Capitella spl (polychaete worm) 323993 Daphnia pulex (daphnia) ENSDARP00000066947 Danio rerio (zebra fish) ENSECAP00000003935 Equus caballus (horse) ENSGACP00000003869 Gymnopilus aculeatus (mushroom) ENSGALP00000013858 Gallus gallus (chicken) 92366 Hypsipyla robusta (cedar shoot borer) ENSP00000320447 Homo sapiens (human) ISCW010278-PA Ixodes scapularis (deer tick) ENSMODP00000008737 Monodelphis domestica (gray opossum) ENSMMUP00000006824 Macaca mulatta (rhesus monkey) ENSMUSP00000109090 Mus musculus (house mouse) ENSOANP00000017249 Ornithorynchus anatinus (platypus) ENSORLP00000013643 Oryzias latipes (japanese killifish) PP18052 Pristionchus pacificus (nematode) ENSPPYP00000014996 Pongo pygmaeus (orangutan) ENSPTRP00000009016 Pan troglodytes (chimpanzee) ENSRNOP00000014354 Rattus norvegicus (norway rat) Smp_105090 Schistosoma mansoni (trematode parasite) XP_001195281.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001813130.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021080 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029267 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000051399 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/hrcp78-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40378 modMine - Data generated by the modENCODE project. • FBgn0015239 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17347 NV16686 LH16476 ISCW010278 FBgn0240168 FBgn0239550 FBgn0227643 FBgn0201008 FBgn0183851 FBgn0177007 JGI_V11_323993 FBgn0080170 FBgn0150387 FBgn0134673 FBgn0124293 FBgn0105502 FBgn0087751 CPIJ001878 BGIBMGA013363 ACYPI004234 GB18358 AGAP008382 AAEL001796 PHUM301950 GLEAN_04598
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG7199 (Lee et al., 2003, Perkins et al., 2009, Keleman et al., 2009.8.5) DHR78 (Li and White, 2003, Baker et al., 2005, Lafont, 2000, Thummel and Chory, 2002, Astle et al., 2003, Gibson and Schubiger, 2001, Robinow et al., 2001, Brennan et al., 2001, Baker et al., 2000, Andrew et al., 2000, Brennan and Moses, 2000, Fisk, 1995.9.20, Nuclear Receptors Nomenclature Committee, 1999, Dressel et al., 1999, Buszczak and Segraves, 1998, Fisk and Thummel, 1998, Russell et al., 1996, Fisk and Thummel, 1995, King-Jones and Thummel, 2005, Baker et al., 2007, Palanker et al., 2006, Liu and Lehmann, 2008, de Rosny et al., 2008, Beckstead et al., 2005, Dubrovsky et al., 2011) Dhr78 (Astle et al., 2003, Thummel, 1995) HR78 (Gritzan et al., 2002, Bloomington Drosophila Stock Center, 1998.3.2, Liu and Lehmann, 2008) Hr78 (Nedelsky et al., 2010, Gim et al., 2001, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Weake et al., 2011, Cronin et al., 2009, Neumüller et al., 2011, Thomsen et al., 2010) Hr78D   NR2D1 (Nuclear Receptors Nomenclature Committee, 1999, King-Jones and Thummel, 2005) XR78E/F (McKeown, 1995.7.12, Zelhof et al., 1995)
Name Synonym	Hormone-receptor-like in 78 (Gim et al., 2001) X receptor at 78E/F (Zelhof et al., 1995)
Secondary FlyBase IDs
References ( 62 )
Generate a list of	All references relating to this gene ( 62 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 4 ) Review  ( 7 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700 The Drosophila FTZ-F1 Nuclear Receptor Mediates Juvenile Hormone Activation of E75A Gene Expression through an Intracellular Pathway. [FBrf0215576] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Nedelsky et al., 2010, Neuron 67(6): 936--952 Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. [FBrf0211903] Thomsen et al., 2010, Genome Biol. 11(9): R93 Genome-wide analysis of mRNA decay patterns during early Drosophila development. [FBrf0212195] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...