FlyBase Gene Report: Dmel\Hr96

General Information

Symbol

Dmel\Hr96

Species

D. melanogaster

Name

Hormone receptor-like in 96

Annotation Symbol

CG11783

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015240

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Snapshot

Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DHR96, NR1J1

Key Links

Genomic Location

Cytogenetic map

96B16-96B17

Sequence location

3R:25,025,235..25,029,351 [+]

Recombination map

3-86

RefSeq locus

NT_033777 REGION:25025235..25029351

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from direct assay

(Fisk and Thummel, 1995)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables nuclear receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

non-traceable author statement

(Maglich et al., 2001)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in cholesterol homeostasis

inferred from mutant phenotype

(Sieber and Thummel, 2012)

involved_in regulation of glycogen metabolic process

inferred from mutant phenotype

(Sieber and Thummel, 2009)

involved_in regulation of transcription by RNA polymerase II

inferred from direct assay

(Bujold et al., 2010)

involved_in response to starvation

inferred from mutant phenotype

(Sieber and Thummel, 2009)

involved_in triglyceride homeostasis

inferred from mutant phenotype

(Sieber and Thummel, 2012, Sieber and Thummel, 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from electronic annotation with InterPro:IPR001628

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Gene Group (FlyBase)

NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the nuclear hormone receptor family. NR1 subfamily. (Q24143)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -: Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).

Protein Function (UniProtKB)

Binds selectively to the HSP27 20E response element.

(UniProt, Q24143)

Summary (Interactive Fly)

nuclear receptor superfamily - regulation of cholesterol and triacylglycerol homeostasis, genetic control of xenobiotic stress responses

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Hr96 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Hr96-RA

FBtr0084756

NM_079769

2834

723

Additional Transcript Data and Comments

Reported size (kB)

2.8, 0.6 (northern blot)

(Fisk and Thummel, 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Hr96-PA

FBpp0084131

81.0

723

6.22

NP_524493

AAF56379

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

723 (aa)

(Fisk and Thummel, 1995)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr96 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hr96_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage & prepupal stage

(Fisk and Thummel, 1995)

Additional Descriptive Data

Hr96 transcripts are expressed throughout third instar larval and prepupal development. A distinct increase in levels is seen at 106hr after egg laying suggesting that they may be ecdysone-inducible. 2.8kb Hr96 transcripts were shown to be ecdysone inducible in cultured larval organs.

(Fisk and Thummel, 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

late third instar larval stage

embryonic/larval fat body

(King-Jones et al., 2006)

embryonic/larval salivary gland

(King-Jones et al., 2006)

embryonic/larval Malpighian tubule

(King-Jones et al., 2006)

gastric caecum

(King-Jones et al., 2006)

embryonic/larval proventriculus

Comment: low level

(King-Jones et al., 2006)

Additional Descriptive Data

Hr96 is most abundantly expressed in the fat body, salivary glands, gastic caeca of the midgut, and Malpighian tubules and more weakly in the proventriculus and anterior region of the midgut in late third instar larvae. No staining is detected in imaginal discs, muscle, epidermis, brain, or trachea.

(King-Jones et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hr96 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hr96

View exonic expression by tissue for Dmel\Hr96

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015240

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0015240

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11783-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11783

Flygut - An atlas of the Drosophila adult midgut

FBgn0015240

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Hr96

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hr96

Transgenic constructs containing regulatory region of Hr96

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

Hr96^UAS.cSa

lethal, with Scer\GAL4^arm.PS

Hr96^dsRNA.UAS.Hp

lethal, with Scer\GAL4^Tub.PU

Hr96^NIG.11783R

viable

Hr96¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Hr96^GD4463

viable, with Scer\GAL4^Mef2.PR

Hr96^GD4463

viable, with Scer\GAL4^pnr-MD237

Hr96^GD4463

viable, with Scer\GAL4^tin.CΔ4

Hr96^GD4463

Sterility

Allele

fertile

Hr96¹

Other Phenotypes

Allele

chemical resistant, with Scer\GAL4^arm.PS

Hr96^dsRNA.UAS.Hp

chemical sensitive

Hr96¹

decreased cell size

Hr96¹

starvation stress response defective

Phenotype manifest in

Allele

adult fat body

adult midgut epithelium

lipid droplet

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (19)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\NR1I2

7 of 15

Yes

Hsap\VDR

6 of 15

Yes

Hsap\NR1I3

4 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\RARB

1 of 15

Yes

Hsap\RARG

1 of 15

Yes

Hsap\RORA

1 of 15

Hsap\RORC

1 of 15

Hsap\THRA

1 of 15

Yes

Hsap\THRB

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Nr1i2

7 of 15

Yes

Mmus\Vdr

6 of 15

Yes

Mmus\Nr1i3

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Rarb

1 of 15

Yes

Mmus\Rarg

1 of 15

Yes

Mmus\Rora

1 of 15

Mmus\Rorc

1 of 15

Mmus\Thra

1 of 15

Yes

Mmus\Thrb

1 of 15

Yes

Rattus norvegicus (Norway rat) (20)

Rnor\Nr1i2

6 of 13

Yes

Rnor\Vdr

5 of 13

Yes

Rnor\Nr1i3

4 of 13

Yes

Rnor\Nr1h2

2 of 13

Rnor\Nr1h3

2 of 13

Rnor\Nr1h4

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Rarb

1 of 13

Yes

Rnor\Rarg

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Thrb

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (17)

Xtro\vdr

6 of 12

Yes

Xtro\nr1i2

5 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\pparg

2 of 12

Yes

Xtro\nr1d1

1 of 12

Xtro\nr1d2

1 of 12

Xtro\nr1i3

1 of 12

Yes

Xtro\rara

1 of 12

Yes

Xtro\rarb

1 of 12

Yes

Xtro\rarg

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (29)

Drer\nr1i2

6 of 15

Yes

Drer\vdra

6 of 15

Yes

Drer\vdrb

6 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\rarab

1 of 15

Yes

Drer\rarga

1 of 15

Yes

Drer\rargb

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\thrab

1 of 15

Yes

Drer\thrb

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\daf-12

7 of 15

Yes

Cele\nhr-48

7 of 15

Yes

Cele\nhr-8

4 of 15

Yes

Cele\nhr-208

1 of 15

Cele\nhr-242

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903ZD )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11197

Drosophila persimilis

Dper\GL24410

Drosophila willistoni

Dwil\GK14276

Drosophila virilis

Dvir\GJ24344

Drosophila mojavensis

Dmoj\GI22223

Drosophila grimshawi

Dgri\Hr96

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915040K )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17011331

Glossina morsitans

Tsetse fly

Gmor\GMOY004314

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06199

Mayetiola destructor

Hessian fly

Mdes\Mdes000136

Aedes aegypti

Yellow fever mosquito

Aaeg\HR96

Anopheles darlingi

American malaria mosquito

Adar\ADAC003041

Anopheles gambiae

Malaria mosquito

Agam\AGAP004224

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016038

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W054E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010783

Bombyx mori

Silkmoth

Bmor\BGIBMGA010782

Danaus plexippus

Monarch butterfly

Dple\DPOGS200543-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016865

Apis florea

Little honeybee

Aflo\3153106276

Apis mellifera

Western honey bee

Amel\GB52904

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22584

Bombus terrestris

Buff-tailed bumblebee

Bter\15210730

Linepithema humile

Argentine ant

Lhum\LH18194

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000a5d

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000370

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04331

Tribolium castaneum

Red flour beetle

Tcas\Hr96

Pediculus humanus

Human body louse

Phum\PHUM460980

Pediculus humanus

Human body louse

Phum\PHUM460970

Rhodnius prolixus

Kissing bug

Rpro\RPRC001794

Cimex lectularius

Bed bug

Clec\CLEC000589

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06284

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X050N )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007355

Ixodes scapularis

Black-legged tick

Isca\ISCW009328

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75069.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur20g01820

Tetranychus urticae

Two-spotted spider mite

Turt\tetur34g00750

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g03630

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g07820

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g03100

Tetranychus urticae

Two-spotted spider mite

Turt\tetur30g01210

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303110

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

EcR

2 of 10

Eip75B

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

VDR; vitamin D receptor

model of rickets

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NR1I2; nuclear receptor subfamily 1 group I member 2

7 of 15

603065

VDR; vitamin D receptor

6 of 15

601769

VITAMIN D-DEPENDENT RICKETS, TYPE 2A; VDDR2A

rickets

NR1I3; nuclear receptor subfamily 1 group I member 3

4 of 15

603881

NR1H3; nuclear receptor subfamily 1 group H member 3

3 of 15

602423

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hr96 - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

RNA-RNA

Physical Interaction

Assay

References

Hr96 - mir-310

quantitative reverse transcription pcr, luminiscence technology

(Çiçek et al., 2016)

Hr96 - mir-311

quantitative reverse transcription pcr, luminiscence technology

(Çiçek et al., 2016)

Hr96 - mir-312

luminiscence technology, quantitative reverse transcription pcr

(Çiçek et al., 2016)

Hr96 - mir-313

quantitative reverse transcription pcr, luminiscence technology

(Çiçek et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67914

DroID - A comprehensive database of gene and protein interactions.

FBgn0015240

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42993

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-86

Cytogenetic map

96B16-96B17

Sequence location

3R:25,025,235..25,029,351 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96B16-96B17

Limits computationally determined from genome sequence between P{PZ}ssh⁰¹²⁰⁷ and P{lacW}OstStt3^j2D9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

96B12-96B14

(Fisk, 1995.9.20)

96B12-96B14

(determined by in situ hybridisation)

(Fisk and Thummel, 1995)

Experimentally Determined Recombination Data

Location

3-86

(FlyBase, 2016)

3-85.3

(Comeron et al., 2012)

(Fisk, 1995.9.20)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Bloomington

76592

TI{TI}Hr96¹

76593

w^*; P{UAS-Hr96.H}2/CyO

44395

w^*; P{UAS-Hr96.miRNA}attP16

38654

w¹¹¹⁸; PBac{FTSF.GFP-Hr96}VK00037

27992

y¹ v¹; P{TRiP.JF02350}attP2

15856

y¹ w^67c23; P{EPgy2}Hr96^EY02171

28869

w¹¹¹⁸; P{UAS-GFP.m6}2; P{hs-GAL4-DHR96.LBD.HA}4.52

29648

w¹¹¹⁸; P{hs-GAL4-DHR96.LBD.HA}8.53; P{UAS-Stinger}3

FlyORF

F003394

M{UAS-Hr96.ORF-CC}ZH-21F

F000910

M{UAS-Hr96.ORF.3xHA.GW}ZH-86Fb

VDRC

v330288

P{VSH330288}attP40

v10958

w¹¹¹⁸; P{GD4463}v10958

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (50)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH14435

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015240

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015240

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42993

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42993

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24143

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015240

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015240

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hr96_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11783

Flygut - An atlas of the Drosophila adult midgut

FBgn0015240

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42993

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010645

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11783

modMine - A data warehouse for the modENCODE project

FBgn0015240

Linkouts

BioGRID - A database of protein and genetic interactions.

67914

DroID - A comprehensive database of gene and protein interactions.

FBgn0015240

DRSC - Results frm RNAi screens

FBgn0015240

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0015240

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11783-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015240

FlyMine - An integrated database for Drosophila genomics

FBgn0015240

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42993

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG11783

(Meadows, 2017.1.11, Hosono et al., 2015, Perkins et al., 2009.3.31)

DHR96

(Misra et al., 2017, Afschar et al., 2016, Çiçek et al., 2016, Palu and Thummel, 2016, Jaumouillé et al., 2015, Hartman et al., 2013, Sieber and Thummel, 2012, Dubrovsky et al., 2011, Niwa and Niwa, 2011, Beaver et al., 2010, Bujold et al., 2010, Giraudo et al., 2010, Horner et al., 2009, Lin et al., 2009, Sieber and Thummel, 2009, de Rosny et al., 2008, Baker et al., 2007, King-Jones et al., 2007, Libert, 2007, Martin et al., 2007, Sieber and Thummel, 2007, King-Jones et al., 2006, King-Jones et al., 2006, King-Jones et al., 2006, Palanker et al., 2006, Goldstein et al., 2005, King-Jones and Thummel, 2005, Li and White, 2003, King-Jones and Thummel, 2002, Thummel and Chory, 2002, King-Jones et al., 2001, Thummel, 2001, Baker et al., 2000, Dressel et al., 1999, Nuclear Receptors Nomenclature Committee, 1999, Russell et al., 1996, Fisk, 1995.9.20, Fisk and Thummel, 1995)

Dhr96

(Shah et al., 2012, Thummel, 1995)

HR96

(Alic et al., 2014, Fahrbach et al., 2012, Lin et al., 2011)

Hr96

(Rust and Nystul, 2020, Toprak et al., 2020, Bischof et al., 2018, Obniski et al., 2018, Transgenic RNAi Project members, 2017-, Schertel et al., 2015, Ugrankar et al., 2015, Kwon et al., 2013, Spokony and White, 2012.5.22, Venken et al., 2009, Curtis et al., 2007)

NR1J1

(King-Jones and Thummel, 2005, Nuclear Receptors Nomenclature Committee, 1999)

dHR96

(Alic et al., 2011)

Name Synonyms

Hormone receptor-like in 96

hormone receptor-like in 96

(Lin et al., 2011)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (93)

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