FB2020_02, released Apr 14, 2020

Gene: Dmel\Hr96

Open Close
General Information
Symbol
Dmel\Hr96
Species
D. melanogaster
Name
Hormone receptor-like in 96
Annotation Symbol
CG11783
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015240
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Snapshot
Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

DHR96, NR1J1

Key Links
Genomic Location
Cytogenetic map
96B16-96B17
Sequence location
3R:25,025,235..25,029,351 [+]
Recombination map

3-86

RefSeq locus
NT_033777 REGION:25025235..25029351
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the nuclear hormone receptor family. NR1 subfamily. (Q24143)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
RNA polymerase II regulatory region sequence-specific DNA binding
Predictions / Assertions
DNA-binding transcription factor activity, RNA polymerase II-specific; ligand-activated transcription factor activity; nuclear receptor activity; nuclear receptor transcription coactivator activity; RNA polymerase II regulatory region sequence-specific DNA binding; signaling receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Summaries
Gene Group (FlyBase)
NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -
Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).
Protein Function (UniProtKB)
Binds selectively to the HSP27 20E response element.
(UniProt, Q24143)
Summary (Interactive Fly)

nuclear receptor superfamily - regulation of cholesterol and triacylglycerol homeostasis, genetic control of xenobiotic stress responses

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Hr96 or the JBrowse view of Dmel\Hr96 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hr96-RA
FBtr0084756
NM_079769
2834
723
Additional Transcript Data and Comments
Reported size (kB)

2.8, 0.6 (northern blot)

(Fisk and Thummel, 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hr96-PA
FBpp0084131
81.0
723
6.22
NP_524493
AAF56379
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

723 (aa)

(Fisk and Thummel, 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr96 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (24 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from direct assay
(Fisk and Thummel, 1995)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
ligand-activated transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
nuclear receptor activity
non-traceable author statement
(Maglich et al., 2001)
nuclear receptor transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
zinc ion binding
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (13 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
cholesterol homeostasis
inferred from mutant phenotype
(Sieber and Thummel, 2012)
regulation of glycogen metabolic process
inferred from mutant phenotype
(Sieber and Thummel, 2009)
regulation of transcription by RNA polymerase II
inferred from direct assay
(Bujold et al., 2010)
response to starvation
inferred from mutant phenotype
(Sieber and Thummel, 2009)
triglyceride homeostasis
inferred from mutant phenotype
(Sieber and Thummel, 2012, Sieber and Thummel, 2009)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular response to lipopolysaccharide
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
cholesterol homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
lipid homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
lipid metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
multicellular organism development
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
response to lipid
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II transcription factor complex
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage & prepupal stage
(Fisk and Thummel, 1995)
Additional Descriptive Data

Hr96 transcripts are expressed throughout third instar larval and prepupal development. A distinct increase in levels is seen at 106hr after egg laying suggesting that they may be ecdysone-inducible. 2.8kb Hr96 transcripts were shown to be ecdysone inducible in cultured larval organs.

(Fisk and Thummel, 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
late third instar larval stage
embryonic/larval fat body
(King-Jones et al., 2006)
embryonic/larval salivary gland
(King-Jones et al., 2006)
embryonic/larval Malpighian tubule
(King-Jones et al., 2006)
gastric caecum
(King-Jones et al., 2006)
embryonic/larval proventriculus

Comment: low level

(King-Jones et al., 2006)
Additional Descriptive Data

Hr96 is most abundantly expressed in the fat body, salivary glands, gastic caeca of the midgut, and Malpighian tubules and more weakly in the proventriculus and anterior region of the midgut in late third instar larvae. No staining is detected in imaginal discs, muscle, epidermis, brain, or trachea.

(King-Jones et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hr96 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hr96
Transgenic constructs containing regulatory region of Hr96
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NR1I2
7 of 15
Yes
Yes
Hsap\VDR
6 of 15
No
Yes
 
Hsap\NR1I3
4 of 15
No
Yes
Hsap\NR1H3
3 of 15
No
No
 
Hsap\NR1H2
2 of 15
No
No
Hsap\NR1H4
2 of 15
No
No
Hsap\PPARA
2 of 15
No
No
Hsap\PPARD
2 of 15
No
No
Hsap\PPARG
2 of 15
No
No
Hsap\RORB
2 of 15
No
No
Hsap\NR1D1
1 of 15
No
No
Hsap\NR1D2
1 of 15
No
No
 
Hsap\RARA
1 of 15
No
Yes
Hsap\RARB
1 of 15
No
Yes
Hsap\RARG
1 of 15
No
Yes
Hsap\RORA
1 of 15
No
No
Hsap\RORC
1 of 15
No
No
Hsap\THRA
1 of 15
No
Yes
Hsap\THRB
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nr1i2
7 of 15
Yes
Yes
Mmus\Vdr
6 of 15
No
Yes
Mmus\Nr1i3
3 of 15
No
Yes
Mmus\Nr1h2
2 of 15
No
No
Mmus\Nr1h3
2 of 15
No
No
Mmus\Nr1h4
2 of 15
No
No
Mmus\Nr1h5
2 of 15
No
No
Mmus\Ppara
2 of 15
No
No
Mmus\Pparg
2 of 15
No
No
Mmus\Rorb
2 of 15
No
No
Mmus\1810013A23Rik
1 of 15
No
Yes
Mmus\Nr1d1
1 of 15
No
No
Mmus\Nr1d2
1 of 15
No
No
Mmus\Ppard
1 of 15
No
No
Mmus\Rara
1 of 15
No
Yes
Mmus\Rarb
1 of 15
No
Yes
Mmus\Rarg
1 of 15
No
Yes
Mmus\Rora
1 of 15
No
No
Mmus\Rorc
1 of 15
No
No
Mmus\Thra
1 of 15
No
Yes
Mmus\Thrb
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (20)
Rnor\Nr1i2
6 of 13
Yes
Yes
Rnor\Vdr
5 of 13
No
Yes
Rnor\Nr1i3
4 of 13
No
Yes
Rnor\Nr1h2
2 of 13
No
No
Rnor\Nr1h3
2 of 13
No
No
Rnor\Nr1h4
2 of 13
No
Yes
Rnor\Nr1h5
2 of 13
No
No
Rnor\Ppara
2 of 13
No
No
Rnor\Ppard
2 of 13
No
No
Rnor\Pparg
2 of 13
No
No
Rnor\Nr1d1
1 of 13
No
No
Rnor\Nr1d2
1 of 13
No
No
Rnor\Rara
1 of 13
No
Yes
Rnor\Rarb
1 of 13
No
Yes
Rnor\Rarg
1 of 13
No
Yes
Rnor\Rora
1 of 13
No
No
Rnor\Rorb
1 of 13
No
No
Rnor\Rorc
1 of 13
No
No
Rnor\Thra
1 of 13
No
Yes
Rnor\Thrb
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (17)
Xtro\vdr
6 of 12
Yes
Yes
Xtro\nr1i2
5 of 12
No
Yes
Xtro\nr1h2
3 of 12
No
No
Xtro\nr1h5
2 of 12
No
No
Xtro\ppara
2 of 12
No
No
Xtro\ppard
2 of 12
No
Yes
Xtro\pparg
2 of 12
No
Yes
Xtro\nr1d1
1 of 12
No
No
Xtro\nr1d2
1 of 12
No
No
Xtro\nr1i3
1 of 12
No
Yes
Xtro\rara
1 of 12
No
Yes
Xtro\rarb
1 of 12
No
Yes
Xtro\rarg
1 of 12
No
Yes
Xtro\rora
1 of 12
No
No
Xtro\rorb.2
1 of 12
No
No
Xtro\rorc
1 of 12
No
No
Xtro\thrb
1 of 12
No
Yes
Danio rerio (Zebrafish) (29)
Drer\nr1i2
6 of 15
Yes
Yes
Drer\vdra
6 of 15
Yes
Yes
Drer\vdrb
6 of 15
Yes
Yes
Drer\nr1h5
3 of 15
No
No
Drer\nr1h3
2 of 15
No
No
Drer\nr1h4
2 of 15
No
No
Drer\pparaa
2 of 15
No
No
Drer\pparab
2 of 15
No
No
Drer\pparda
2 of 15
No
No
Drer\ppardb
2 of 15
No
No
Drer\nr1d1
1 of 15
No
No
Drer\nr1d2a
1 of 15
No
No
Drer\nr1d2b
1 of 15
No
No
Drer\nr1d4a
1 of 15
No
No
Drer\nr1d4b
1 of 15
No
No
Drer\pparg
1 of 15
No
No
Drer\raraa
1 of 15
No
Yes
Drer\rarab
1 of 15
No
Yes
Drer\rarga
1 of 15
No
Yes
Drer\rargb
1 of 15
No
Yes
Drer\roraa
1 of 15
No
No
Drer\rorab
1 of 15
No
No
Drer\rorb
1 of 15
No
No
Drer\rorca
1 of 15
No
No
Drer\rorcb
1 of 15
No
No
Drer\rorc
1 of 15
No
No
Drer\thraa
1 of 15
No
Yes
Drer\thrab
1 of 15
No
Yes
Drer\thrb
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\daf-12
7 of 15
Yes
Yes
Cele\nhr-48
7 of 15
Yes
Yes
Cele\nhr-8
4 of 15
No
Yes
Cele\nhr-208
1 of 15
No
No
Cele\nhr-242
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903ZD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010838
Drosophila simulans
Dsim\GD21158
Drosophila sechellia
Dsec\GM17786
Drosophila erecta
Dere\GG11347
Drosophila yakuba
Dyak\GE23543
Drosophila ananassae
Dana\GF16320
Drosophila pseudoobscura pseudoobscura
Dpse\GA11197
Drosophila persimilis
Dper\GL24410
Drosophila willistoni
Dwil\GK14276
Drosophila virilis
Dvir\GJ24344
Drosophila mojavensis
Dmoj\GI22223
Drosophila grimshawi
Dgri\Hr96
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915040K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011331
Glossina morsitans
Tsetse fly
Gmor\GMOY004314
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06199
Mayetiola destructor
Hessian fly
Mdes\Mdes000136
Aedes aegypti
Yellow fever mosquito
Aaeg\HR96
Anopheles darlingi
American malaria mosquito
Adar\ADAC003041
Anopheles gambiae
Malaria mosquito
Agam\AGAP004224
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016038
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W054E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010783
Bombyx mori
Silkmoth
Bmor\BGIBMGA010782
Danaus plexippus
Monarch butterfly
Dple\DPOGS200543-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016865
Apis florea
Little honeybee
Aflo\3153106276
Apis mellifera
Western honey bee
Amel\GB52904
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22584
Bombus terrestris
Buff-tailed bumblebee
Bter\15210730
Linepithema humile
Argentine ant
Lhum\LH18194
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000a5d
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000370
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04331
Tribolium castaneum
Red flour beetle
Tcas\Hr96
Pediculus humanus
Human body louse
Phum\PHUM460980
Pediculus humanus
Human body louse
Phum\PHUM460970
Rhodnius prolixus
Kissing bug
Rpro\RPRC001794
Cimex lectularius
Bed bug
Clec\CLEC000589
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06284
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X050N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007355
Ixodes scapularis
Black-legged tick
Isca\ISCW009328
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75069.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g01820
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g00750
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g03630
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07820
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g03100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur30g01210
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303110
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
EcR
2 of 10
Eip75B
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    VDR; vitamin D receptor
    model of  rickets
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NR1I2; nuclear receptor subfamily 1 group I member 2
    7 of 15
    603065
        VDR; vitamin D receptor
        6 of 15
        601769
         
        NR1I3; nuclear receptor subfamily 1 group I member 3
        4 of 15
        603881
            NR1H3; nuclear receptor subfamily 1 group H member 3
            3 of 15
            602423
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Hr96 - Ubx
                bimolecular fluorescence complementation, fluorescence microscopy
                (Bischof et al., 2018)
                RNA-RNA
                Physical Interaction
                Assay
                References
                Hr96 - mir-310
                luminiscence technology, quantitative reverse transcription pcr
                (Çiçek et al., 2016)
                Hr96 - mir-311
                quantitative reverse transcription pcr, luminiscence technology
                (Çiçek et al., 2016)
                Hr96 - mir-312
                luminiscence technology, quantitative reverse transcription pcr
                (Çiçek et al., 2016)
                Hr96 - mir-313
                quantitative reverse transcription pcr, luminiscence technology
                (Çiçek et al., 2016)
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map

                3-86

                Cytogenetic map
                96B16-96B17
                Sequence location
                3R:25,025,235..25,029,351 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                96B16-96B17
                Limits computationally determined from genome sequence between P{PZ}ssh01207 and P{lacW}OstStt3j2D9
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                96B12-96B14
                (Fisk, 1995.9.20)
                96B12-96B14
                (determined by in situ hybridisation)
                (Fisk and Thummel, 1995)
                Experimentally Determined Recombination Data
                Location

                3-86

                (FlyBase, 2016)

                3-85.3

                (Comeron et al., 2012)

                3-

                (Fisk, 1995.9.20)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (15)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (50)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Additional comments
                  Other Comments
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 35 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  Synonyms and Secondary IDs (9)
                  Reported As
                  Symbol Synonym
                  CG11783
                  (Meadows, 2017.1.11, Hosono et al., 2015, Perkins et al., 2009.3.31)
                  DHR96
                  (Misra et al., 2017, Afschar et al., 2016, Çiçek et al., 2016, Palu and Thummel, 2016, Jaumouillé et al., 2015, Hartman et al., 2013, Sieber and Thummel, 2012, Dubrovsky et al., 2011, Niwa and Niwa, 2011, Beaver et al., 2010, Bujold et al., 2010, Giraudo et al., 2010, Horner et al., 2009, Lin et al., 2009, Sieber and Thummel, 2009, de Rosny et al., 2008, Baker et al., 2007, King-Jones et al., 2007, Libert, 2007, Martin et al., 2007, Sieber and Thummel, 2007, King-Jones et al., 2006, King-Jones et al., 2006, King-Jones et al., 2006, Palanker et al., 2006, Goldstein et al., 2005, King-Jones and Thummel, 2005, Li and White, 2003, King-Jones and Thummel, 2002, Thummel and Chory, 2002, King-Jones et al., 2001, Thummel, 2001, Baker et al., 2000, Dressel et al., 1999, Nuclear Receptors Nomenclature Committee, 1999, Russell et al., 1996, Fisk, 1995.9.20, Fisk and Thummel, 1995)
                  Dhr96
                  (Shah et al., 2012, Thummel, 1995)
                  HR96
                  (Alic et al., 2014, Fahrbach et al., 2012, Lin et al., 2011)
                  Hr96
                  (Bischof et al., 2018, Obniski et al., 2018, Transgenic RNAi Project members, 2017-, Schertel et al., 2015, Ugrankar et al., 2015, Kwon et al., 2013, Spokony and White, 2012.5.22, Venken et al., 2009, Curtis et al., 2007)
                  NR1J1
                  (King-Jones and Thummel, 2005, Nuclear Receptors Nomenclature Committee, 1999)
                  dHR96
                  (Alic et al., 2011)
                  Name Synonyms
                  Hormone receptor-like in 96
                  hormone receptor-like in 96
                  (Lin et al., 2011)
                  Secondary FlyBase IDs
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (90)