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Gene Dmel\Hsp60

General Information
Symbol	Dmel\Hsp60	Species	D. melanogaster
Name	Heat shock protein 60	Annotation symbol	CG12101
Feature type	protein_coding_gene	FlyBase ID	FBgn0015245
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	l(1)BP5, Hsp60A, 12
Genomic Location
Chromosome (arm)	X	Recombination map	1-33.51
Cytogenetic map	10A4-10A4	Sequence location	X:11,002,506..11,006,341 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Heat shock protein 60 is referred to in FlyBase by the symbol Dmel\Hsp60 (CG12101, FBgn0015245). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: unfolded protein binding. There is experimental evidence that it is involved in the biological process: cellular response to heat; mitochondrion organization. 56 alleles are reported. The phenotypes of these alleles are annotated with: blastoderm embryo; tergite. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Chaperonin Cpn60; Chaperonin Cpn60, conserved site; Chaperonin Cpn60/TCP-1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval Malpighian tubules, larval fat body, adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1641286_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Hsp60. Gene sequence location is X:11002506..11006341.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27896 HFA20254
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A4-10A4   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10A4-10A5     (Zurita, 1996.7.6) 10A1-10A11     (Caggese, 1996.10.24) 10A1-10A4   (determined by in situ hybridisation)   (Caggese et al., 1999) 10A4-10A5   (determined by in situ hybridisation)   (Zurita et al., 1995)
Experimentally Determined Recombination Data
Location	1-33.51   1-33.47 (Geer et al., 1983) 1- (Caggese, 1996.10.24)
Left of (cM)	l(1)10Ae rtv (Zhimulev et al., 1981)
Right of (cM)	v sev csk slm (Zhimulev et al., 1981)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hsp60 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hsp60-RA FBtr0073434  NM_078560   2366   573 Hsp60-RB FBtr0073435  NM_167266   2328   573
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hsp60-PA   FBpp0073290   60.8   573   5.11     NP_511115   AAF47999 Hsp60-PB   FBpp0073291   60.8   573   5.11     NP_727489   AAF47998
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chaperonin Cpn60, conserved site (IPR018370) Chaperonin Cpn60 (IPR001844) Chaperonin Cpn60/TCP-1 (IPR002423) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12101
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201257   AA201660   AA202576   AA246252   AA263220   AA391130   AA392760   AA539472   AA567236   AA694744   AA696151   AA696248   AA696560   AA696782   AA697847   AA803618   AA803828   AA804054   AA804082   AA817075   AA820235   AA820868   AA821042   AA938862   AA941215   AA941936   AA942076   AA948881   AA949519   AA949528   AA950325   AA951088   AA979150   AE014298 AAF47998   AE014298 AAF47999   AI106885   AI108097   AI108171   AI109181   AI109781   AI113596   AI135978   AI238536   AI239161   AI292535   AI292742   AI296971   AI389794   AI402296   AI402438   AI405063   AI405293   AI455842   AI456485   AI456585   AI456616   AI456678   AI511739   AI511822   AI513600   AI513850   AI514146   AI516101   AI517559   AI518036   AI518145   AI518206   AI519330   AI519406   AI531028   AI531487   AI532088   AI532395   AI533395   AI533544   AI533866   AI534086   AI541814   AI542117   AI542174   AI542534   AI542687   AI542832   AI543395   AI546499   AI546564   AI945992   AW944462   AY113273   BF486594   BF492314   BF492349   BF493712   BF494794   BF495558   BF496009   BF496528   BF496639   BF497310   BF497976   BF498638   BF498860   BF498880   BF500144   BF504645   BF505039   BF505082   BF505693   BF506044   BG631965   BG633884   BG634178   BG635048   BG635277   BG635302   BG635778   BG636960   BG637007   BG640772   BI165861   BI166348   BI168749   BI170885   BI171804   BI228294   BI230173   BI231659   BI236969   BI237214   BI237905   BI238988   BI241913   BI243579   BI243765   BI352666   BI353695   BI353835   BI353843   BI355278   BI355437   BI355453   BI364088   BI366224   BI366253   BI368326   BI368747   BI370590   BI370673   BI371398   BI482161   BI482909   BI568258   BI568336   BI568625   BI569891   BI570540   BI570909   BI571255   BI571868   BI572061   BI572771   BI572791   BI578017   BI579127   BI581250   BI581543   BI582334   BI582452   BI586555   BI586925   BI591347   BI591510   BI592041   BI592955   BI593103   BI604500   BI605203   BI606289   BI607287   BI607649   BI611513   BI612309   BI612319   BI612720   BI613162   BI613214   BI613538   BI614146   BI614208   BI614272   BI614953   BI615333   BI615334   BI617281   BI617682   BI618764   BI618989   BI619083   BI619358   BI620015   BI624834   BI625238   BI626490   BI627597   BI627662   BI627894   BI629110   BI629417   BI629639   BI631122   BI631552   BI633544   BI634735   BI636164   BI636768   BI639110   BI639370   BI641214   BQ103362   BT001308   BT010206 AAQ23524   BT099644   BX031108   BZ748837   BZ748838   CK130444   CK570281   CK660846   CO156920   CO267279   CO298971   CO299500   CO300221   CO309088   CO312074   CO319032   CO330387   CO335686   CO338380   CO344200   EC053501   EC054683   EC066995   EC072946   EC078941   EC089573   EC222626   EC227002   EC234648   EC241289   EC249666   EC250330   EC259647   EC263495   EC267727   EL872899   EL883008   EL883009   EL883741   EL883742   EV576769   EV580716   EV582083   EV584028   GH739057   GH739159   GH739444   GH739773   GH740119   GH740560   GH740588   GH740863   GH741117   GH741211   GH742110   GH742244   GH742257   GH742323   GH742372   GH742626   GH742633   GH743500   GH743950   GH744166   GH744591   GH744794   GH745225   GH745341   GH745487   GH745536   GH745595   GH745872   GH745926   GH745967   GH746160   GH746391   GH746586   GH746693   GH747301   GH761553   GH761554   GH762598   GH762901   GH763687   GH763827   GH764089   GH764167   GH764677   GH764747   GH764879   GH764958   GH765528   GH765663   GH765990   GH766195   GH766372   GH766529   GH766599   GH766673   GH766829   GH767129   GH767466   GH767739   GH769000   GH769007   GH769674   GO254371   GO254404   GO254523   X99341 CAA67720   Y09066 CAA70287
UniProtKB/Swiss-Prot	O02649
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015245    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015245 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015245 expression level Developmental Stage   Expression Level embryo 00-02hr    29514 embryo 02-04hr    2609 embryo 04-06hr    1601 embryo 06-08hr    7826 embryo 08-10hr    15298 embryo 10-12hr    41420 embryo 12-14hr    24456 embryo 14-16hr    45135 embryo 16-18hr    30986 embryo 18-20hr    20940 embryo 20-22hr    23435 embryo 22-24hr    16959 larva L1    56608 larva L2    45556 larva L3 12hr old    35933 larva L3 puffstage 1-2    6227 larva L3 puffstage 3-6    7226 larva L3 puffstage 7-9    6742 white prepupae new    6844 white prepupae 12hr    7119 white prepupae 24hr    8610 pupae 2d postWPP    17858 pupae 3d postWPP    14328 pupae 4d postWPP    14090 adult male 01day    11958 adult male 05day    13766 adult male 30day    15226 adult female 01day    35049 adult female 05day    32471 adult female 30day    33519 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (29514) embryo 02-04hr  (2609) embryo 04-06hr  (1601) embryo 06-08hr  (7826) embryo 08-10hr  (15298) embryo 10-12hr  (41420) embryo 12-14hr  (24456) embryo 14-16hr  (45135) embryo 16-18hr  (30986) embryo 18-20hr  (20940) embryo 20-22hr  (23435) embryo 22-24hr  (16959) larva L1  (56608) larva L2  (45556) larva L3 12hr old  (35933) larva L3 puffstage 1-2  (6227) larva L3 puffstage 3-6  (7226) larva L3 puffstage 7-9  (6742) white prepupae new  (6844) white prepupae 12hr  (7119) white prepupae 24hr  (8610) pupae 2d postWPP  (17858) pupae 3d postWPP  (14328) pupae 4d postWPP  (14090) adult male 01day  (11958) adult male 05day  (13766) adult male 30day  (15226) adult female 01day  (35049) adult female 05day  (32471) adult female 30day  (33519) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (29514) embryo 02-04hr  (2609) embryo 04-06hr  (1601) embryo 06-08hr  (7826) embryo 08-10hr  (15298) embryo 10-12hr  (41420) embryo 12-14hr  (24456) embryo 14-16hr  (45135) embryo 16-18hr  (30986) embryo 18-20hr  (20940) embryo 20-22hr  (23435) embryo 22-24hr  (16959) larva L1  (56608) larva L2  (45556) larva L3 12hr old  (35933) larva L3 puffstage 1-2  (6227) larva L3 puffstage 3-6  (7226) larva L3 puffstage 7-9  (6742) white prepupae new  (6844) white prepupae 12hr  (7119) white prepupae 24hr  (8610) pupae 2d postWPP  (17858) pupae 3d postWPP  (14328) pupae 4d postWPP  (14090) adult male 01day  (11958) adult male 05day  (13766) adult male 30day  (15226) adult female 01day  (35049) adult female 05day  (32471) adult female 30day  (33519) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (29514) embryo 02-04hr    2609 embryo 04-06hr    1601 embryo 06-08hr    7826 embryo 08-10hr  (15298) embryo 10-12hr  (41420) embryo 12-14hr  (24456) embryo 14-16hr  (45135) embryo 16-18hr  (30986) embryo 18-20hr  (20940) embryo 20-22hr  (23435) embryo 22-24hr  (16959) larva L1  (56608) larva L2  (45556) larva L3 12hr old  (35933) larva L3 puffstage 1-2    6227 larva L3 puffstage 3-6    7226 larva L3 puffstage 7-9    6742 white prepupae new    6844 white prepupae 12hr    7119 white prepupae 24hr    8610 pupae 2d postWPP  (17858) pupae 3d postWPP  (14328) pupae 4d postWPP  (14090) adult male 01day  (11958) adult male 05day  (13766) adult male 30day  (15226) adult female 01day  (35049) adult female 05day  (32471) adult female 30day  (33519) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29514 embryo 02-04hr    2609 embryo 04-06hr    1601 embryo 06-08hr    7826 embryo 08-10hr    15298 embryo 10-12hr    41420 embryo 12-14hr    24456 embryo 14-16hr    45135 embryo 16-18hr    30986 embryo 18-20hr    20940 embryo 20-22hr    23435 embryo 22-24hr    16959 larva L1    56608 larva L2    45556 larva L3 12hr old    35933 larva L3 puffstage 1-2    6227 larva L3 puffstage 3-6    7226 larva L3 puffstage 7-9    6742 white prepupae new    6844 white prepupae 12hr    7119 white prepupae 24hr    8610 pupae 2d postWPP    17858 pupae 3d postWPP    14328 pupae 4d postWPP    14090 adult male 01day    11958 adult male 05day    13766 adult male 30day    15226 adult female 01day    35049 adult female 05day    32471 adult female 30day    33519 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015245 expression level Developmental Stage   Expression Level embryo 00-02hr    29514 embryo 02-04hr    2609 embryo 04-06hr    1601 embryo 06-08hr    7826 embryo 08-10hr    15298 embryo 10-12hr    41420 embryo 12-14hr    24456 embryo 14-16hr    45135 embryo 16-18hr    30986 embryo 18-20hr    20940 embryo 20-22hr    23435 embryo 22-24hr    16959 larva L1    56608 larva L2    45556 larva L3 12hr old    35933 larva L3 puffstage 1-2    6227 larva L3 puffstage 3-6    7226 larva L3 puffstage 7-9    6742 white prepupae new    6844 white prepupae 12hr    7119 white prepupae 24hr    8610 pupae 2d postWPP    17858 pupae 3d postWPP    14328 pupae 4d postWPP    14090 adult male 01day    11958 adult male 05day    13766 adult male 30day    15226 adult female 01day    35049 adult female 05day    32471 adult female 30day    33519 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (29514) embryo 02-04hr  (2609) embryo 04-06hr  (1601) embryo 06-08hr  (7826) embryo 08-10hr  (15298) embryo 10-12hr  (41420) embryo 12-14hr  (24456) embryo 14-16hr  (45135) embryo 16-18hr  (30986) embryo 18-20hr  (20940) embryo 20-22hr  (23435) embryo 22-24hr  (16959) larva L1  (56608) larva L2  (45556) larva L3 12hr old  (35933) larva L3 puffstage 1-2  (6227) larva L3 puffstage 3-6  (7226) larva L3 puffstage 7-9  (6742) white prepupae new  (6844) white prepupae 12hr  (7119) white prepupae 24hr  (8610) pupae 2d postWPP  (17858) pupae 3d postWPP  (14328) pupae 4d postWPP  (14090) adult male 01day  (11958) adult male 05day  (13766) adult male 30day  (15226) adult female 01day  (35049) adult female 05day  (32471) adult female 30day  (33519) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (29514) embryo 02-04hr  (2609) embryo 04-06hr  1601 embryo 06-08hr  (7826) embryo 08-10hr  (15298) embryo 10-12hr  (41420) embryo 12-14hr  (24456) embryo 14-16hr  (45135) embryo 16-18hr  (30986) embryo 18-20hr  (20940) embryo 20-22hr  (23435) embryo 22-24hr  (16959) larva L1  (56608) larva L2  (45556) larva L3 12hr old  (35933) larva L3 puffstage 1-2  (6227) larva L3 puffstage 3-6  (7226) larva L3 puffstage 7-9  (6742) white prepupae new  (6844) white prepupae 12hr  (7119) white prepupae 24hr  (8610) pupae 2d postWPP  (17858) pupae 3d postWPP  (14328) pupae 4d postWPP  (14090) adult male 01day  (11958) adult male 05day  (13766) adult male 30day  (15226) adult female 01day  (35049) adult female 05day  (32471) adult female 30day  (33519) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (29514) embryo 02-04hr    2609 embryo 04-06hr    1601 embryo 06-08hr    7826 embryo 08-10hr  15298 embryo 10-12hr  (41420) embryo 12-14hr  (24456) embryo 14-16hr  (45135) embryo 16-18hr  (30986) embryo 18-20hr  (20940) embryo 20-22hr  (23435) embryo 22-24hr  16959 larva L1  (56608) larva L2  (45556) larva L3 12hr old  (35933) larva L3 puffstage 1-2    6227 larva L3 puffstage 3-6    7226 larva L3 puffstage 7-9    6742 white prepupae new    6844 white prepupae 12hr    7119 white prepupae 24hr    8610 pupae 2d postWPP  17858 pupae 3d postWPP  14328 pupae 4d postWPP  14090 adult male 01day  11958 adult male 05day  13766 adult male 30day  15226 adult female 01day  (35049) adult female 05day  (32471) adult female 30day  (33519) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29514 embryo 02-04hr    2609 embryo 04-06hr    1601 embryo 06-08hr    7826 embryo 08-10hr    15298 embryo 10-12hr    41420 embryo 12-14hr    24456 embryo 14-16hr    45135 embryo 16-18hr    30986 embryo 18-20hr    20940 embryo 20-22hr    23435 embryo 22-24hr    16959 larva L1    56608 larva L2    45556 larva L3 12hr old    35933 larva L3 puffstage 1-2    6227 larva L3 puffstage 3-6    7226 larva L3 puffstage 7-9    6742 white prepupae new    6844 white prepupae 12hr    7119 white prepupae 24hr    8610 pupae 2d postWPP    17858 pupae 3d postWPP    14328 pupae 4d postWPP    14090 adult male 01day    11958 adult male 05day    13766 adult male 30day    15226 adult female 01day    35049 adult female 05day    32471 adult female 30day    33519 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015245    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015245 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval Malpighian tubules, larval fat body, adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015245 expression level Tissue   Expression Level Larval Central Nervous System    979.925 Larval Midgut    489.5 Larval Hindgut    1173.4 Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland    971.7 Larval Trachea    1116.075 Larval Carcass    766.25 Adult Head    1144.3 Adult Eye    621.225 Adult Brain    1702.6 Adult Thoracic-Abdominal Ganglion    2154.9 Adult Crop    727.8 Adult Midgut    509.3 Adult Hindgut    678.1 Adult Malpighian Tubules    1246.9 Adult Fat Body    1165.3 Adult Salivary Gland    401.6 Adult Heart    1046.25 Adult VirginFemale Spermatheca    992.1 Adult InseminatedFemale Spermatheca    1246.9 Adult Ovary    1745.4 Adult Testis    722.8 Adult Male Accessory Gland    765.7 Adult Carcass    889.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (979.925) Larval Midgut    489.5 Larval Hindgut  (1173.4) Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland  (971.7) Larval Trachea  (1116.075) Larval Carcass  (766.25) Adult Head  (1144.3) Adult Eye  (621.225) Adult Brain  (1702.6) Adult Thoracic-Abdominal Ganglion  (2154.9) Adult Crop  (727.8) Adult Midgut  509.3 Adult Hindgut  (678.1) Adult Malpighian Tubules  (1246.9) Adult Fat Body  (1165.3) Adult Salivary Gland    401.6 Adult Heart  (1046.25) Adult VirginFemale Spermatheca  (992.1) Adult InseminatedFemale Spermatheca  (1246.9) Adult Ovary  (1745.4) Adult Testis  (722.8) Adult Male Accessory Gland  (765.7) Adult Carcass  (889.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    979.925 Larval Midgut    489.5 Larval Hindgut  (1173.4) Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland    971.7 Larval Trachea  (1116.075) Larval Carcass    766.25 Adult Head  (1144.3) Adult Eye    621.225 Adult Brain  (1702.6) Adult Thoracic-Abdominal Ganglion  (2154.9) Adult Crop    727.8 Adult Midgut    509.3 Adult Hindgut    678.1 Adult Malpighian Tubules  (1246.9) Adult Fat Body  (1165.3) Adult Salivary Gland    401.6 Adult Heart  1046.25 Adult VirginFemale Spermatheca    992.1 Adult InseminatedFemale Spermatheca  (1246.9) Adult Ovary  (1745.4) Adult Testis    722.8 Adult Male Accessory Gland    765.7 Adult Carcass    889.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    979.925 Larval Midgut    489.5 Larval Hindgut    1173.4 Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland    971.7 Larval Trachea    1116.075 Larval Carcass    766.25 Adult Head    1144.3 Adult Eye    621.225 Adult Brain    1702.6 Adult Thoracic-Abdominal Ganglion    2154.9 Adult Crop    727.8 Adult Midgut    509.3 Adult Hindgut    678.1 Adult Malpighian Tubules    1246.9 Adult Fat Body    1165.3 Adult Salivary Gland    401.6 Adult Heart    1046.25 Adult VirginFemale Spermatheca    992.1 Adult InseminatedFemale Spermatheca    1246.9 Adult Ovary    1745.4 Adult Testis    722.8 Adult Male Accessory Gland    765.7 Adult Carcass    889.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015245 expression level Tissue   Expression Level Larval Central Nervous System    979.925 Larval Midgut    489.5 Larval Hindgut    1173.4 Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland    971.7 Larval Trachea    1116.075 Larval Carcass    766.25 Adult Head    1144.3 Adult Eye    621.225 Adult Brain    1702.6 Adult Thoracic-Abdominal Ganglion    2154.9 Adult Crop    727.8 Adult Midgut    509.3 Adult Hindgut    678.1 Adult Malpighian Tubules    1246.9 Adult Fat Body    1165.3 Adult Salivary Gland    401.6 Adult Heart    1046.25 Adult VirginFemale Spermatheca    992.1 Adult InseminatedFemale Spermatheca    1246.9 Adult Ovary    1745.4 Adult Testis    722.8 Adult Male Accessory Gland    765.7 Adult Carcass    889.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (979.925) Larval Midgut    489.5 Larval Hindgut  (1173.4) Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland  (971.7) Larval Trachea  (1116.075) Larval Carcass  766.25 Adult Head  (1144.3) Adult Eye  621.225 Adult Brain  (1702.6) Adult Thoracic-Abdominal Ganglion  (2154.9) Adult Crop  727.8 Adult Midgut  509.3 Adult Hindgut  678.1 Adult Malpighian Tubules  (1246.9) Adult Fat Body  (1165.3) Adult Salivary Gland    401.6 Adult Heart  (1046.25) Adult VirginFemale Spermatheca  (992.1) Adult InseminatedFemale Spermatheca  (1246.9) Adult Ovary  (1745.4) Adult Testis  722.8 Adult Male Accessory Gland  765.7 Adult Carcass  (889.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    979.925 Larval Midgut    489.5 Larval Hindgut  1173.4 Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland    971.7 Larval Trachea  1116.075 Larval Carcass    766.25 Adult Head  1144.3 Adult Eye    621.225 Adult Brain  1702.6 Adult Thoracic-Abdominal Ganglion  (2154.9) Adult Crop    727.8 Adult Midgut    509.3 Adult Hindgut    678.1 Adult Malpighian Tubules  1246.9 Adult Fat Body  1165.3 Adult Salivary Gland    401.6 Adult Heart  1046.25 Adult VirginFemale Spermatheca    992.1 Adult InseminatedFemale Spermatheca  1246.9 Adult Ovary  (1745.4) Adult Testis    722.8 Adult Male Accessory Gland    765.7 Adult Carcass    889.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    979.925 Larval Midgut    489.5 Larval Hindgut    1173.4 Larval Malpighian Tubules    163.1 Larval Fat Body    364.9 Larval Salivary Gland    971.7 Larval Trachea    1116.075 Larval Carcass    766.25 Adult Head    1144.3 Adult Eye    621.225 Adult Brain    1702.6 Adult Thoracic-Abdominal Ganglion    2154.9 Adult Crop    727.8 Adult Midgut    509.3 Adult Hindgut    678.1 Adult Malpighian Tubules    1246.9 Adult Fat Body    1165.3 Adult Salivary Gland    401.6 Adult Heart    1046.25 Adult VirginFemale Spermatheca    992.1 Adult InseminatedFemale Spermatheca    1246.9 Adult Ovary    1745.4 Adult Testis    722.8 Adult Male Accessory Gland    765.7 Adult Carcass    889.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1144.3   NA  Eye    621.225   NA  Brain    1702.6   979.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2154.9   NA  Crop    727.8   489.5  Midgut    509.3   1173.4  Hindgut    678.1   163.1  Malpighian Tubules    1246.9   364.9  Fat Body    1165.3   971.7  Salivary Gland    401.6   NA  Heart    1046.25   1116.075  Trachea    NA   NA  VirginFemale Spermatheca    992.1   NA  InseminatedFemale Spermatheca    1246.9   NA  Ovary    1745.4   NA  Testis    722.8   NA  Male Accessory Gland    765.7   766.25  Carcass    889.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015245 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12101-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Hsp60 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | germline clone Hsp60DA514 lethal Hsp6023Y Hsp6024Y Hsp6025Y Hsp6041Y Hsp6042Y Hsp60164 Hsp60169 Hsp60187 Hsp60193 Hsp60E54 Hsp60E112 Hsp60E114 Hsp60E120 Hsp60F409 Hsp60F437 Hsp60G62 Hsp60G67 Hsp60G76 Hsp60G93 Hsp60G95 Hsp60G96 Hsp60G105 Hsp60G139 Hsp60J21 Hsp60L12 Hsp60S5 Hsp60S10 Hsp60S14 Hsp60S15 Hsp60S21 Hsp60S26 Hsp60S32 Hsp60S35 Hsp60S37 Hsp60S38 Hsp60v201 Hsp60v202 lethal, with Scer\GAL4pnr-MD237 Hsp60GD7481 lethal | cold sensitive Hsp60HM21 lethal | embryonic stage | recessive Hsp60BP5409 Hsp60F409 Hsp60F437 Hsp60G93 lethal | heat sensitive Hsp60F230 lethal | larval stage Hsp60L12 lethal | larval stage | recessive Hsp60164 Hsp60169 Hsp60193 Hsp60E120 Hsp60J21 Hsp60VE772 lethal | polyphasic Hsp60DA514 lethal | polyphasic | recessive Hsp60DA514 lethal | pupal stage, with Scer\GAL4pnr-MD237 Hsp60GD7481 lethal | recessive Hsp6036 Hsp6041Y Hsp6042Y Hsp60v201 Hsp60v202 lethal | recessive | heat sensitive Hsp60F439 Other Phenotypes Allele wild-type Hsp60+t15 Phenotype manifest in Allele blastoderm embryo Hsp60F409 tergite Hsp60F230 Hsp60HM21
Classical Alleles ( 52 )
For All Classical Alleles Show
Allele of Hsp60 Class Mutagen Stocks Known lesion Hsp60GF319 X ray 2 -- Hsp60RA75 X ray 2 -- Hsp60EY01572 P-element activity 1 -- Hsp60164 ethyl methanesulfonate 0 -- Hsp60169 ethyl methanesulfonate 0 -- Hsp60187 ethyl methanesulfonate 0 -- Hsp60193 ethyl methanesulfonate 0 -- Hsp6023Y ethyl methanesulfonate 0 -- Hsp6024Y ethyl methanesulfonate 0 -- Hsp6025Y ethyl methanesulfonate 0 -- Hsp6036 ethyl methanesulfonate 0 -- Hsp6041Y ethyl methanesulfonate 0 -- Hsp6042Y ethyl methanesulfonate 0 -- Hsp60A114 X ray 0 -- Hsp60BP5409 ethyl methanesulfonate 0 Yes Hsp60C202 X ray 0 -- Hsp60DA514 ethyl methanesulfonate X ray 0 -- Hsp60E112 ethyl methanesulfonate 0 -- Hsp60E114 ethyl methanesulfonate 0 -- Hsp60E120 ethyl methanesulfonate 0 -- Hsp60E54 ethyl methanesulfonate 0 -- Hsp60F230 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Hsp60F409 ethyl methanesulfonate 0 Yes Hsp60F437 ethyl methanesulfonate 0 -- Hsp60F439 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Hsp60G105 ethyl methanesulfonate 0 -- Hsp60G139 ethyl methanesulfonate 0 -- Hsp60G62 ethyl methanesulfonate 0 -- Hsp60G67 ethyl methanesulfonate 0 -- Hsp60G76 ethyl methanesulfonate 0 -- Hsp60G93 ethyl methanesulfonate 0 Yes Hsp60G95 ethyl methanesulfonate 0 -- Hsp60G96 ethyl methanesulfonate 0 -- Hsp60HM21 ethyl methanesulfonate 0 -- Hsp60J21 ethyl methanesulfonate 0 -- Hsp60L12 X ray 0 -- Hsp60S10 PM hybrid dysgenesis 0 Yes Hsp60S14 PM hybrid dysgenesis 0 -- Hsp60S15 PM hybrid dysgenesis 0 Yes Hsp60S21 PM hybrid dysgenesis 0 Yes Hsp60S26 PM hybrid dysgenesis 0 Yes Hsp60S32 PM hybrid dysgenesis 0 -- Hsp60S35 PM hybrid dysgenesis 0 -- Hsp60S37 PM hybrid dysgenesis 0 Yes Hsp60S38 PM hybrid dysgenesis 0 Yes Hsp60S5 PM hybrid dysgenesis 0 -- Hsp60v201 ethyl methanesulfonate 0 -- Hsp60v202 ethyl methanesulfonate 0 -- Hsp60VA160 ethyl methanesulfonate 0 -- Hsp60VA244 ethyl methanesulfonate 0 -- Hsp60VE772 ethyl methanesulfonate 0 -- Hsp60VE815 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hsp60 Class Mutagen Stocks Known lesion Hsp60GD7481 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hsp60HMS01209 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hsp60KK107896 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hsp60+t15 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)v65b (Zhimulev et al., 1981, Kozlova et al., 1994) Df(1)v-L1 (Zhimulev et al., 1981, Zhimulev, 1982, Kramers et al., 1983, Bgatov et al., 1986, Zhimulev et al., 1987, Pokholkova et al., 1991, Kozlova et al., 1994) Df(1)v-L3 (Zhimulev et al., 1981, Kramers et al., 1983, Zhimulev et al., 1987, Pokholkova et al., 1991, Kozlova et al., 1994)
Duplicated in	Dp(1;2)v+63i (Zhimulev et al., 1981, Kramers et al., 1983, Zhimulev et al., 1987) Dp(1;2)v+65b (Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1987) Dp(1;2)v+75d (Geer et al., 1983) Dp(1;Y)v+y+ (Zhimulev et al., 1981, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1987) Dp(1;Y)v+y+366 (Zhimulev et al., 1987)
Not disrupted in	Df(1)59D3 (Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)203C10 (Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)HC133 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)HM456 (Kramers et al., 1983) Df(1)KA7 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)N71 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)RA37 (Zhimulev et al., 1981, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1987, Pokholkova et al., 1991, Kozlova et al., 1994) Df(1)ras-P14 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)ras-v17 (Zhimulev et al., 1981, Zhimulev et al., 1987, Pokholkova et al., 1991, Kozlova et al., 1994) Df(1)ras-v-P26 (Zhimulev et al., 1987) Df(1)sbr1 (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)sbr8 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr9 (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)sbr10 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sev-P1 (Kozlova et al., 1994) Df(1)v64f (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-B151 (Zhimulev et al., 1987) Df(1)v-L2 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987, Pokholkova et al., 1991, Kozlova et al., 1994) Df(1)v-L4 (Zhimulev et al., 1981, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-L7 (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-L11 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-L15 (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-M1 (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-M5 (Zhimulev et al., 1981, Zhimulev et al., 1987, Pokholkova et al., 1991, Kozlova et al., 1994) Df(1)v-M6 (Zhimulev et al., 1981, Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-M7 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-P5 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-P16 (Zhimulev et al., 1987, Kozlova et al., 1994) Df(1)v-P22 (Zhimulev et al., 1987, Kozlova et al., 1994) In(1)wm4hrx500 (Kozlova et al., 1994)
Not duplicated in	Dp(1;Y)dsh+y+ (Zhimulev et al., 1987) Dp(1;Y)v+y+U15 (Zhimulev et al., 1987)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7481} NA P{KK107896} NA P{TRiP.HMS01209} NA characterization construct P{Hsp60+15} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Hsp60EY01572 NA miscellaneous insertions P{}Hsp60S5 NA P{}Hsp60S10 NA P{}Hsp60S14 NA P{}Hsp60S15 NA P{}Hsp60S21 NA P{}Hsp60S26 NA P{}Hsp60S32 NA P{}Hsp60S35 NA P{}Hsp60S37 NA P{}Hsp60S38 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular response to heat inferred from expression pattern (Baena-López et al., 2008) mitochondrion organization inferred from mutant phenotype (Baena-López et al., 2008) NOT response to heat inferred from expression pattern (San Martin et al., 1995)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrial inner membrane inferred from direct assay (Baena-López et al., 2008) mitochondrion inferred from direct assay (San Martin et al., 1995)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR002423, InterPro:IPR018370 (FlyBase Curators et al., 2004-) unfolded protein binding inferred from sequence or structural similarity with UniProtKB:P10809 (Sardiello et al., 2003.6.11) inferred from sequence or structural similarity with UniProtKB:P50140 (FlyBase, 1992-)
Biological Process
CV term Evidence References
'de novo' protein folding inferred from sequence or structural similarity with UniProtKB:P10809 (Sardiello et al., 2003.6.11) protein folding inferred from sequence or structural similarity with UniProtKB:P50140 (FlyBase, 1992-) protein refolding inferred from electronic annotation with InterPro:IPR001844 (FlyBase Curators et al., 2004-) protein targeting to mitochondrion inferred from sequence or structural similarity with UniProtKB:P10809 (Sardiello et al., 2003.6.11) response to heat inferred from sequence or structural similarity with UniProtKB:P50140 (FlyBase, 1992-) non-traceable author statement (Caggese, 1996.10.24)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from sequence or structural similarity with UniProtKB:P10809 (Sardiello et al., 2003.6.11) inferred from sequence or structural similarity with UniProtKB:P50140 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hsp60 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58460 DroID - A comprehensive database of gene and protein interactions. • FBgn0015245 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32045
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20294 Dere\GG18391 Dgri\GH17925 Dmoj\GI16304 Dpse\GA22684 Dsim\GD17003 Dvir\GJ15640 Dwil\GK16370 Dyak\GE15908
Curated drosophilid orthologs	Dpse\GA11395
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011584-PA Aedes aegypti (mosquito) AGAP004002-PA Anopheles gambiae (mosquito) XP_392899.2 Apis mellifera (honey bee) XP_001951373.1 Acyrthosiphon pisum (pea aphid) At2g33210.1 Arabidopsis thaliana (wall cress) At3g23990.1 Arabidopsis thaliana (wall cress) 18035 Batrachochytrium dendrobatidis (chytrid fungus) 115228 Branchiostoma floridae (lancelet) XP_001902773.1 Brugia malayi (roundworm nematode) BGIBMGA007349-PA Bombyx mori (silk worm) ENSBTAP00000016708 Bos taurus (bovine) CAL0001744 Candida albicans (a form of yeast) CN18082 Caenorhabditis brenneri (small nematode) CBP02856 Caenorhabditis briggsae (nematode) CE27244 Caenorhabditis elegans (worm) ENSCAFP00000016007 Canis familiaris (dog) CAGL0K05973g Candida glabrata (haploid yeast) Chro.60573 Cryptosporidium hominis (obligate parasite) ENSCINP00000016018 Ciona intestinalis (sea squirt) JA17115 Caenorhabditis japonica (nematode) CMQ270C Cyanidioschyzon merolae (red alga) cn02194 Cryptococcus neoformans (yeast-like fungus) cgd6_4970 Cryptosporidium parvum (protozoan parasite) CPIJ008889 Culex pipens (mosquito) ENSCPOP00000016987 Cavia porcellus (guinea pig) 115081 Chlamidomonas reinhardtii (green alga) RP30720 Caenorhabditis remanei (nematode) ENSCSAVP00000001187 Ciona savignyi (sedentary tunicate) 179778 Capitella spl (polychaete worm) DDB0219929 Dictyostelium discoideum (amoeba) DEHA2E05808g Debaryomyces Hansenii (yeast) 301074 Daphnia pulex (daphnia) ENSDARP00000073057 Danio rerio (zebra fish) ENSECAP00000007167 Equus caballus (horse) NP_418567.1 Escherichia coli K12 (bacteria) XP_656268 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000011870 Gymnopilus aculeatus (mushroom) ENSGALP00000013122 Gallus gallus (chicken) 186090 Hypsipyla robusta (cedar shoot borer) ENSP00000340019 Homo sapiens (human) ISCW017824-PA Ixodes scapularis (deer tick) KLLA0F09449g Kluyveromyces lactis (yeast) 237408 Lottia gigantea (owl limpet) LmjF36.2030 Leishmania major (virus) 37718 Monocosta brevicollis (choanoflagellate) ENSMODP00000034855 Monodelphis domestica (gray opossum) ENSMMUP00000013745 Macaca mulatta (rhesus monkey) ENSMUSP00000027123 Mus musculus (house mouse) 178049 Nematostella vectensis (starlet anemone) XP_001600045.1 Nasonia vitripennis (wasp) ENSOANP00000016514 Ornithorynchus anatinus (platypus) ENSORLP00000025853 Oryzias latipes (japanese killifish) LOC_Os10g32550.1 Oryza sativa (asian rice) 28971 Ostreococcus tauri (green alga) PF10_0153 Plasmodium falciparum (protozoal parasite) PHUM003100-PA Pediculus humanus (human body louse) PP05717 Pristionchus pacificus (nematode) 226792 Physcomitrella patens (moss) ENSPPYP00000014577 Pongo pygmaeus (orangutan) 71587 Phytophthora ramorum (sudden oak death pathogen) 109597 Phytophthora sojae (root rot pathogen) 829355 Populus trichocarpa (black cottonwood) ENSPTRP00000021826 Pan troglodytes (chimpanzee) PVX_095000 Plasmodium vivax (protozoal parasite) ENSRNOP00000019912 Rattus norvegicus (norway rat) 4742803 Sorghum bicolor (sorghum) YLR259C Saccharomyces cerevisiae (budding yeast) SPAC12G12.04 Schizosaccharomyces pombe (fission yeast) XP_795205.2 Strongylocentrotus purpuratus (purple sea urchin) 54071 Trichoplax adhaerens (metazoa) TA07065 Theileria annulata (apicomplexan parasite) XP_971630.1 Tribolium castaneum (red flour beetle) Tc00.1047053507641.290 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014481 Tetraodon nigroviridis (green spotted pufferfish) TP04_0066 Theileria parva (parasitic protozoan) 38191 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039868 Takifugu rubripes (pufferfish Takifugu) 16.m00478 Tetrahymena thermophila (ciliate protozoa) 83260.m00099 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000016354 Xenopus tropicalis (frog) YALI0F02805g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17377 LH18427 ISCW017824 FBgn0242613 FBgn0233468 FBgn0218372 FBgn0216694 FBgn0202830 FBgn0202755 FBgn0194741 FBgn0188580 FBgn0173471 FBgn0250194 JGI_V11_301074 FBgn0244087 FBgn0163954 FBgn0140300 FBgn0139052 FBgn0031728 FBgn0125393 FBgn0118519 FBgn0117217 FBgn0110607 FBgn0097301 FBgn0092600 CPIJ008889 BGIBMGA007349 ACYPI47197 ACYPI009253 GB18969 AGAP004002 AAEL011584 PB24919 PHUM397230 GLEAN_13683
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	4689 T(1;2;3)RA75, Hsp60RA75/FM7a 4686 T(1;2)GF319, l(1)8Aa3 Hsp60GF319/FM7a 15361 y1 w67c23 P{EPgy2}Hsp60EY01572 34729 y1 sc* v1; P{TRiP.HMS01209}attP2/TM3, Sb1
Kyoto	107838 Hsp60RA75/FM7a 107836 T(1;2)GF319, l(1)8Aa3 Hsp60GF319/FM7a
VDRC	v100697 P{KK107896}VIE-260B v18738 w1118; P{GD7481}v18738 v18739 w1118; P{GD7481}v18739
Genomic Clones ( 1 )
	BACR26J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 320 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13565 AT16985 SD06594
Other clones	DPiM_AT13565 FI05241
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02044 AT03534 AT04505 AT06244 AT07196 AT07246 AT07434 AT07969 AT08402 AT09712 AT10290 AT10525 AT11456 AT12320 AT13082 AT13290 AT13418 AT15054 AT20990 AT26764 AT29233 AT29277 AT29842 AT30303 AT31507 AT31805 AT31832 GH06838 GH06938 GH08302 GH09127 GH13935 GH14593 GH15458 GH15714 GH17244 GH21057 GH21659 GH24975 GH25248 GH27217 GH28564 GM01458 GM02204 GM04304 GM05174 GM05369 GM05479 GM07881 GM08389 GM12674 GM12763 GM13663 GM14374 GM15109 GM20285 GM24768 GM25324 GM25347 GM30185 GM30777 GM30880 HL03315 LD02717 LD03956 LD04195 LD06055 LD06326 LD10228 LD11868 LD17620 LD22102 LD23743 LD24787 LD25234 LD26106 LD27285 LD27556 LD28350 LD28361 LD28848 LD31373 LD33429 LD35555 LD36521 LD36652 LD36694 LD36778 LD37439 LD37571 LD38873 LD39004 LD41856 LD43240 LD43354 LD45787 LD48090 LP11105 LP14390 LP19769 RE13657 RE25775 RE33101 RE33402 RE34237 RE35366 RE39114 RE41260 RE41479 RE49133 RE51720 RE51751 RE54770 RE57279 RE57386 RE58276 RE64819 RE65718 RE71810 RE73111 RH02886 RH05107 RH05295 RH05695 RH06093 RH07173 RH10788 RH17832 RH18616 RH20541 RH26617 RH40736 RH41664 RH42322 RH42706 RH43451 RH43532 RH50053 RH58278 RH58537 RH60535 RH64540 RH65537 RH67448 RH68951 RH69032 RH69365 RH74753 SD01884 SD02546 SD03455 SD03896 SD05189 SD05411 SD05838 SD06359 SD06995 SD08209 SD08309 SD08881 SD09126 SD09307 SD10134 SD11918 SD13267 SD14792 SD14851 SD17753 SD18583 SD21561 SD21937 SD24431 SD27660
Other clones	34259 47501 57500 157331 163602 164452 174886 192286 293602 299944 bs19c07 CK01.56B.C10 Dmel_dig_010136_0657_2485 Dmel_dig_016448_0709_1679 Dmel_dig_017049_0665_2613 Dmel_dig_020100_0717_1523 EC053501 EC054683 EC259647 EK149323 EK174220 EK175563 EK177642 EK227832 EK260241 EK276035 EK295125 EN09556 EN10963 EN16650 EP18836 GH06135 GH09960 GH26948 HL04558 IP04741 IP12704 IP13401 LD37652 RE05843 RE06448 RE09611 RE12488 RE22963 RE54277 RH02072 RH07401 RH08407 RH08429 RH09643 RH11008 RH19042 RH20319 RH27152 RH38955 RH39666 RH39761 RH40255 RH40748 RH42257 RH43614 RH44457 RH44940 RH44941 RH47558 RH48089 RH49667 RH49945 RH50379 RH51170 RH57924 RH61143 RH69888 RH70749 RH72558 RH74321 RP01173 RP01239 RP01556 RP001002230 RP001002388 RP001002539 RP001002677 RP001003157 RP001005705 RP001005943 RP001006506 RP001007371 RP001007900 RP001008060 RP001010104 RP001010427 RP001010526 RP001011230 RP001011252 RP001011748 RP001012008 RP001013927 RP001014613 RP001014893 RP001015053 RP001015061 RP001015263 RP001016049 RP001016354 RP001017854 RP001019188 RP001019266 RP001019667 RP001020215 RP001021693 RP001024500 RP001024544 RP001029251 RP001029778 RP001031312 RP001031513 RP001031813 RP001034107 RP001034182 RP001035652 RP001036095 RP001036850 RP001038640 RP001039256 RP001043402 RP001044022 RP001044152 RP001044978 RP001047620 RP001047766 RP001049044 RP001049130 RP001051518 RP001052086 RP001052706 RP001052748 RP001053532 RP001054539 RP001055537 RP001056133 UUGC0765
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015245 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32045
Antibody Information
	polyclonal (Baena-López et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The Hsp60B gene may have been derived from the Hsp60 gene by retroposition. (Dai et al., 2006) The Hsp60C gene may be derived from the Hsp60 gene by retroposition. (Betran et al., 2002) May correspond to the l(1)10Ac locus. (Zurita et al., 1995) Complementation relations among complementing alleles complex and vary according to temperature of rearing, some combinations being heat sensitive and others cold-sensitive. Allelism to Hsp60L12 established for the Russian alleles by Zhimulev et al. and for the G8 alleles by Geer et al. (1983).
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation and cell size. (Guertin et al., 2006) Hsp60 is essential from the early stages of embryogenesis. (Kozlova et al., 1997) Sequence analysis of l(1)10Ac locus suggests it encodes Hsp60. Molecular analysis of a P-element insertion and genetic rescue experiments confirm l(1)10Ac encodes Hsp60. Hsp60 is differentially expressed throughout development, protein distribution is very dynamic during embryogenesis accumulating in specific cell types. (Kozlova et al., 1997) A protein crossreacting to mammalian CPN60 is detected in the mitochondria of SL2 cells. (San Martin et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078560 NM_167266 RefSeq (Proteins) • NP_511115 NP_727489 DDBJ / EMBL / GenBank • AAF47998 AAF47999 AAQ23524 AI517559 AI534086 AI945992 AW944462 BT010206 BZ748837 BZ748838 CAA67720 CAA70287 X99341 Y09066 Entrez Gene - A searchable database of RefSeq genes. • 32045 UniProtKB/Swiss-Prot • O02649
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chaperonin Cpn60, conserved site (IPR018370) Chaperonin Cpn60 (IPR001844) Chaperonin Cpn60/TCP-1 (IPR002423) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12101
Linkouts
	BioGRID - A database of protein and genetic interactions • 58460 DroID - A comprehensive database of gene and protein interactions. • FBgn0015245 DRSC - Results from RNAi screens. • FBgn0015245 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015245 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12101-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015245 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32045 InParanoid A subset of ortholog calls from InParanoid. • AAEL011584-PA Aedes aegypti (mosquito) AGAP004002-PA Anopheles gambiae (mosquito) XP_392899.2 Apis mellifera (honey bee) XP_001951373.1 Acyrthosiphon pisum (pea aphid) At2g33210.1 Arabidopsis thaliana (wall cress) At3g23990.1 Arabidopsis thaliana (wall cress) 18035 Batrachochytrium dendrobatidis (chytrid fungus) 115228 Branchiostoma floridae (lancelet) XP_001902773.1 Brugia malayi (roundworm nematode) BGIBMGA007349-PA Bombyx mori (silk worm) ENSBTAP00000016708 Bos taurus (bovine) CAL0001744 Candida albicans (a form of yeast) CN18082 Caenorhabditis brenneri (small nematode) CBP02856 Caenorhabditis briggsae (nematode) CE27244 Caenorhabditis elegans (worm) ENSCAFP00000016007 Canis familiaris (dog) CAGL0K05973g Candida glabrata (haploid yeast) Chro.60573 Cryptosporidium hominis (obligate parasite) ENSCINP00000016018 Ciona intestinalis (sea squirt) JA17115 Caenorhabditis japonica (nematode) CMQ270C Cyanidioschyzon merolae (red alga) cn02194 Cryptococcus neoformans (yeast-like fungus) cgd6_4970 Cryptosporidium parvum (protozoan parasite) CPIJ008889 Culex pipens (mosquito) ENSCPOP00000016987 Cavia porcellus (guinea pig) 115081 Chlamidomonas reinhardtii (green alga) RP30720 Caenorhabditis remanei (nematode) ENSCSAVP00000001187 Ciona savignyi (sedentary tunicate) 179778 Capitella spl (polychaete worm) DDB0219929 Dictyostelium discoideum (amoeba) DEHA2E05808g Debaryomyces Hansenii (yeast) 301074 Daphnia pulex (daphnia) ENSDARP00000073057 Danio rerio (zebra fish) ENSECAP00000007167 Equus caballus (horse) NP_418567.1 Escherichia coli K12 (bacteria) XP_656268 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000011870 Gymnopilus aculeatus (mushroom) ENSGALP00000013122 Gallus gallus (chicken) 186090 Hypsipyla robusta (cedar shoot borer) ENSP00000340019 Homo sapiens (human) ISCW017824-PA Ixodes scapularis (deer tick) KLLA0F09449g Kluyveromyces lactis (yeast) 237408 Lottia gigantea (owl limpet) LmjF36.2030 Leishmania major (virus) 37718 Monocosta brevicollis (choanoflagellate) ENSMODP00000034855 Monodelphis domestica (gray opossum) ENSMMUP00000013745 Macaca mulatta (rhesus monkey) ENSMUSP00000027123 Mus musculus (house mouse) 178049 Nematostella vectensis (starlet anemone) XP_001600045.1 Nasonia vitripennis (wasp) ENSOANP00000016514 Ornithorynchus anatinus (platypus) ENSORLP00000025853 Oryzias latipes (japanese killifish) LOC_Os10g32550.1 Oryza sativa (asian rice) 28971 Ostreococcus tauri (green alga) PF10_0153 Plasmodium falciparum (protozoal parasite) PHUM003100-PA Pediculus humanus (human body louse) PP05717 Pristionchus pacificus (nematode) 226792 Physcomitrella patens (moss) ENSPPYP00000014577 Pongo pygmaeus (orangutan) 71587 Phytophthora ramorum (sudden oak death pathogen) 109597 Phytophthora sojae (root rot pathogen) 829355 Populus trichocarpa (black cottonwood) ENSPTRP00000021826 Pan troglodytes (chimpanzee) PVX_095000 Plasmodium vivax (protozoal parasite) ENSRNOP00000019912 Rattus norvegicus (norway rat) 4742803 Sorghum bicolor (sorghum) YLR259C Saccharomyces cerevisiae (budding yeast) SPAC12G12.04 Schizosaccharomyces pombe (fission yeast) XP_795205.2 Strongylocentrotus purpuratus (purple sea urchin) 54071 Trichoplax adhaerens (metazoa) TA07065 Theileria annulata (apicomplexan parasite) XP_971630.1 Tribolium castaneum (red flour beetle) Tc00.1047053507641.290 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014481 Tetraodon nigroviridis (green spotted pufferfish) TP04_0066 Theileria parva (parasitic protozoan) 38191 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039868 Takifugu rubripes (pufferfish Takifugu) 16.m00478 Tetrahymena thermophila (ciliate protozoa) 83260.m00099 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000016354 Xenopus tropicalis (frog) YALI0F02805g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32045 modMine - Data generated by the modENCODE project. • FBgn0015245 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17377 LH18427 ISCW017824 FBgn0242613 FBgn0233468 FBgn0218372 FBgn0216694 FBgn0202830 FBgn0202755 FBgn0194741 FBgn0188580 FBgn0173471 FBgn0250194 JGI_V11_301074 FBgn0244087 FBgn0163954 FBgn0140300 FBgn0139052 FBgn0031728 FBgn0125393 FBgn0118519 FBgn0117217 FBgn0110607 FBgn0097301 FBgn0092600 CPIJ008889 BGIBMGA007349 ACYPI47197 ACYPI009253 GB18969 AGAP004002 AAEL011584 PB24919 PHUM397230 GLEAN_13683
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	12 (Lefevre and Watkins, 1986, Lefevre, 1981) BP5 (Zurita et al., 1995) CG12101 (Beller et al., 2006, Nakahara et al., 2005, Kang et al., 2002, Labourier et al., 2002, Cermelli et al., 2006, Dai et al., 2006, Keleman et al., 2009.8.5, Hughes et al., 2008, Chen et al., 2008, Ni et al., 2010.12.1, Riedl et al., 2005, Cammarato et al., 2011) Cpn60 (San Martin et al., 1995) cpn60 (San Martin et al., 1995) d-hsp60 (Adan et al., 2008) Dmhsp60 (Perezgasga et al., 1999) G62 (Kramers et al., 1983) hsp60 (Gorska-Andrzejak et al., 2003, Kang et al., 2002, Zurita, 1996.7.6, Karunanithi et al., 1999, Perezgasga et al., 1998, Frydman et al., 2006, Singh et al., 2009, Moussian et al., 2005) Hsp60 (Beller et al., 2006, Beller et al., 2006, Mack et al., 2006, Guertin et al., 2006, Cermelli et al., 2006, Langille and Clark, 2007, Walser et al., 2006, Bettencourt et al., 2008, Laayouni et al., 2007, Takemori and Yamamoto, 2009, Babenko et al., 2009, Birch-Machin et al., 2005, Chen et al., 2008, Anholt and Williams, 2010, Colinet et al., 2010, Sun et al., 2011, Riedl et al., 2005) HSP60 (Shaw et al., 2002) Hsp60A (Sarkar and Lakhotia, 2005, Grant et al., 2010) hsp60A (Baena-López et al., 2008) HSP60A (Baena-López et al., 2008) IEF16 (Baena-López et al., 2008) l(1)10Ac   l(1)BP5 (Pokholkova and Zhimulev, 1984, Pokholkova et al., 1991, Pokholkova and Solov'eva, 1989, Zhimulev et al., 1987, Bgatov et al., 1986, Zhimulev, 1982, Zhimulev et al., 1981, ) l(1)dp025   l(1)G8   l(1)HM21   l(1)L12   Mmp-P1   SSP 7506 (Baena-López et al., 2008)
Name Synonym	Heat shock protein 60 (Zurita et al., 1995, Cermelli et al., 2006, Cammarato et al., 2011) heat shock protein 60 (Mack et al., 2006, Baena-López et al., 2008, Sun et al., 2011) heat shock protein 60 kDa (Caggese, 1996.10.24) Hsp 60 (Takemori and Yamamoto, 2009) lethal(1)10Ac   Mitochondrial matrix protein P1
Secondary FlyBase IDs
	FBgn0001483 FBgn0001749 FBgn0004659 FBgn0010375
References ( 83 )
Generate a list of	All references relating to this gene ( 83 )
List References by type	Research paper  ( 60 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 4 )
	Sun et al., 2011, PLoS ONE 6(4): e18215 Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. [FBrf0213560] Anholt and Williams, 2010, Chem. Senses 35(1): 21--30 The soluble proteome of the Drosophila antenna. [FBrf0209552] Colinet et al., 2010, FEBS J. 277(1): 174--185 Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster. [FBrf0209693] Grant et al., 2010, Dis. Model Mech. 3(11-12): 799--806 A Drosophila model for primary coenzyme Q deficiency and dietary rescue in the developing nervous system. [FBrf0212188] Show all research papers ...