FB2019_05, released Oct 15, 2019

Gene: Dmel\Diap2

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General Information
Symbol
Dmel\Diap2
Species
D. melanogaster
Name
Death-associated inhibitor of apoptosis 2
Annotation Symbol
CG8293
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015247
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Death-associated inhibitor of apoptosis 2 (Diap2) encodes a protein with ubiquitin E3-ligase activity that functions in the Imd pathway by conjugating the product of imd with K63-polyubiquitin chains. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
Iap2, DIAP-2, DIAP, DIHA, D-iap2
Key Links
Genomic Location
Cytogenetic map
52D2-52D2
Sequence location
2R:15,932,170..15,934,825 [-]
Recombination map
2-76
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the IAP family. (Q24307)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
caspase binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding
Predictions / Assertions
cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ubiquitin protein ligase activity; zinc ion binding
Summaries
Gene Group (FlyBase)
INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Inhibitor of APoptosis (IAP) ubiquitin ligases are defined by the presence of one or more BIR (baculoviral IAP repeat) and a UBA (ubiquitin (Ub)-associated domain) domain that binds polyubiquitin and a RING finger domain. (Adapted from FBrf0216918).
INHIBITOR OF APOPTOSIS -
Inhibitor of APoptosis (IAP) proteins are defined by the presence of one or more BIR (baculoviral IAP repeat) domains. Not all IAPs inhibit apoptosis, but some interact with and inhibit caspases via their BIR domains. This interaction is displaced by RHG protein binding. (Adapted from FBrf0215539).
Pathway (FlyBase)
Imd Signaling Pathway Core Components -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
Protein Function (UniProtKB)
Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria (PubMed:16894030, PubMed:17068333). Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides (PubMed:17068333, PubMed:24374974). Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides (PubMed:22549468). Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice (PubMed:18166655). Suppresses rpr and hid-dependent cell death in the eye (PubMed:8548811). However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway (PubMed:17068333). Plays a role in regulating the expression of ion channels (PubMed:24374974).
(UniProt, Q24307)
Summary (Interactive Fly)
N-terminal baculovirus IAP repeat domain and C-terminal RING ubiquitin ligase domain protein - required for immune response to bacteria - promotes cytoplasmic cleavage and nuclear translocation of the NF-kappaB homolog Relish - controls the level of caspase activity by forming a covalent adduct with the catalytic machinery of drICE
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Diap2 or the JBrowse view of Dmel\Diap2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Diap2-RA
FBtr0087296
NM_057779
2106
498
Diap2-RB
FBtr0087297
NM_176182
1997
498
Additional Transcript Data and Comments
Reported size (kB)
2.3 (northern blot)
(Duckett et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Diap2-PA
FBpp0086431
54.5
498
4.91
NP_477127
AAF58095
Diap2-PB
FBpp0086432
54.5
498
4.91
NP_788362
AAO41389
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

498 aa isoforms: Diap2-PA, Diap2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
497 (aa); 54 (kD predicted)
(Duckett et al., 1996)
498 (aa)
(Liston et al., 1996, Hay et al., 1995)
498 (aa); 55 (kD predicted)
(Uren et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with the caspase Strica (PubMed:11550090). Interacts (via BIR2 domain) with rpr and grim (PubMed:18166655). Interacts (via the BIR2 and BIR3 domains) with hid (PubMed:18166655). Interacts (via BIR3 domain) with Drice (PubMed:18166655). Interacts with Dredd; likely to bind Dredd simultaneously with Fadd to form a trimeric complex (PubMed:22549468).
(UniProt, Q24307)
Post Translational Modification
Caspase-dependent cleavage is required for suppression of Drice-mediated cell death.
(UniProt, Q24307)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Diap2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (22 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
caspase binding
inferred from physical interaction with FLYBASE:Drice; FB:FBgn0019972
(Leulier et al., 2006)
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
inferred from direct assay
(Ribeiro et al., 2007)
protein binding
inferred from physical interaction with FLYBASE:rpr; FB:FBgn0011706
(Vucic et al., 1997)
ubiquitin protein ligase activity
inferred from direct assay
(Aalto et al., 2019, Yeh and Bratton, 2013, Paquette et al., 2010, Herman-Bachinsky et al., 2007, Ribeiro et al., 2007)
ubiquitin protein ligase binding
inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635
(Herman-Bachinsky et al., 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000005168
(assigned by GO_Central )
(Gaudet et al., 2011)
ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(assigned by GO_Central )
(Gaudet et al., 2011)
zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (13 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
chaeta development
inferred from mutant phenotype
(Kanuka et al., 2005)
defense response to Gram-negative bacterium
inferred from mutant phenotype
(Meinander et al., 2012, Huh et al., 2007, Leulier et al., 2006)
negative regulation of apoptotic process
inferred from direct assay
(Hawkins et al., 1998, Vucic et al., 1997)
inferred from mutant phenotype
(Ribeiro et al., 2007)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
inferred from genetic interaction with FLYBASE:Drice; FB:FBgn0019972
(Ribeiro et al., 2007)
inferred from direct assay
(Harvey et al., 2001)
peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Chen et al., 2017, Meinander et al., 2012, Paquette et al., 2010, Ertürk-Hasdemir et al., 2009, Valanne et al., 2007, Leulier et al., 2006, Kleino et al., 2005)
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from mutant phenotype
(Kleino et al., 2005)
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
protein K48-linked ubiquitination
inferred from direct assay
(Herman-Bachinsky et al., 2007)
protein K63-linked ubiquitination
inferred from direct assay
(Aalto et al., 2019, Meinander et al., 2012)
protein ubiquitination
inferred from direct assay
(Yeh and Bratton, 2013)
regulation of cysteine-type endopeptidase activity involved in apoptotic process
inferred from mutant phenotype
(Leulier et al., 2006)
ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Herman-Bachinsky et al., 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000005168
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of protein ubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
perinuclear region of cytoplasm
inferred from direct assay
(Vucic et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000005166
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000005166
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
(Duckett et al., 1996)
Additional Descriptive Data
Iap2 transcripts are expressed at high levels in embryos, larvae, and adults.
(Duckett et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
perinuclear region of cytoplasm
inferred from direct assay
(Vucic et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Diap2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Diap2
Transgenic constructs containing regulatory region of Diap2
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of pupal stage, with Scer\GAL4da.G32
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2R)Exel7138)
Sterility
Allele
fertile
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
cell death defective | conditional
cell death defective | conditional (with Df(2R)Exel7138)
immune response defective
immune response defective, with Scer\GAL4c564
immune response defective (with Df(2R)Exel7138)
immune response defective (with Diap27a)
immune response defective (with Diap27c)
radiation sensitive
radiation sensitive (with Df(2R)Exel7138)
some die during pupal stage, with Scer\GAL4da.G32
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-P309
Phenotype manifest in
Allele
eye | P-stage
macrochaeta | supernumerary, with Scer\GAL4sca-P309
mesothoracic tergum, with Scer\GAL4pnr-MD237
pigment cell
trichogen cell, with Scer\GAL4pnr-MD237
wing disc
wing disc (with Df(2R)Exel7138)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BIRC2
14 of 15
Yes
Yes
Hsap\BIRC3
13 of 15
No
Yes
Hsap\XIAP
10 of 15
No
Yes
 
Hsap\BIRC7
8 of 15
No
Yes
Hsap\BIRC8
7 of 15
No
Yes
Hsap\BIRC5
4 of 15
No
No
Hsap\NAIP
4 of 15
No
Yes
Hsap\BIRC6
1 of 15
No
No
Hsap\MYLIP
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Birc2
14 of 15
Yes
Yes
Mmus\Birc3
13 of 15
No
Yes
Mmus\Xiap
9 of 15
No
Yes
Mmus\Birc7
7 of 15
No
Yes
Mmus\Naip5
5 of 15
No
Yes
Mmus\Naip1
4 of 15
No
Yes
Mmus\Naip2
4 of 15
No
Yes
Mmus\Naip6
4 of 15
No
Yes
Mmus\Birc5
3 of 15
No
No
Mmus\Birc6
1 of 15
No
No
Mmus\Naip7
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (9)
Rnor\Birc2
12 of 13
Yes
Yes
Rnor\Birc3
12 of 13
Yes
Yes
Rnor\Xiap
7 of 13
No
Yes
Rnor\Birc7
6 of 13
No
Yes
Rnor\Birc5
2 of 13
No
No
Rnor\Birc6
1 of 13
No
No
Rnor\LOC499715
1 of 13
No
Yes
Rnor\Naip5
1 of 13
No
Yes
Rnor\Naip6
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (15)
Xtro\birc2
8 of 12
Yes
Yes
Xtro\birc7
7 of 12
No
Yes
Xtro\xiap
6 of 12
No
Yes
Xtro\birc5.1
5 of 12
No
No
Xtro\birc5.2
3 of 12
No
No
Xtro\birc6
1 of 12
No
No
Xtro\LOC100487218
1 of 12
No
Yes
Xtro\LOC100490339
1 of 12
No
Yes
Xtro\LOC100492519
1 of 12
No
Yes
Xtro\LOC101732421
1 of 12
No
Yes
Xtro\LOC101733194
1 of 12
No
Yes
Xtro\LOC108645626
1 of 12
No
Yes
Xtro\LOC108645627
1 of 12
No
Yes
Xtro\LOC108648784
1 of 12
No
Yes
Xtro\naip
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\birc2
14 of 15
Yes
Yes
Drer\xiap
6 of 15
No
Yes
Drer\birc7
5 of 15
No
Yes
Drer\birc5b
4 of 15
No
No
Drer\birc5a
2 of 15
No
No
Drer\birc6
1 of 15
No
No
Drer\mylipb
1 of 15
No
No
Drer\zgc:171740
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\bir-2
7 of 15
Yes
Yes
Cele\bir-1
3 of 15
No
No
Cele\K11D12.9
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT4G03000
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\BIR1
3 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\bir1
6 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919069K )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Diap2
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005558
Drosophila simulans
Dsim\GD25587
Drosophila sechellia
Dsec\GM20110
Drosophila erecta
Dere\GG22322
Drosophila yakuba
Dyak\Iap2
Drosophila ananassae
Dana\GF13337
Drosophila pseudoobscura pseudoobscura
Dpse\GA20963
Drosophila persimilis
Dper\GL16260
Drosophila willistoni
Dwil\GK21897
Drosophila virilis
Dvir\GJ20901
Drosophila mojavensis
Dmoj\GI21299
Drosophila grimshawi
Dgri\GH20962
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503JW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009426
Glossina morsitans
Tsetse fly
Gmor\GMOY003276
Mayetiola destructor
Hessian fly
Mdes\Mdes004372
Aedes aegypti
Yellow fever mosquito
Aaeg\IAP2
Anopheles darlingi
American malaria mosquito
Adar\ADAC002192
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019231
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0793 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011524
Bombyx mori
Silkmoth
Bmor\BGIBMGA011523
Danaus plexippus
Monarch butterfly
Dple\DPOGS203759-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203744-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002562
Heliconius melpomene
Postman butterfly
Hmel\Iap2
Apis florea
Little honeybee
Aflo\2883636708
Apis florea
Little honeybee
Aflo\2883637284
Apis florea
Little honeybee
Aflo\2160270786
Apis mellifera
Western honey bee
Amel\LOC726172
Apis mellifera
Western honey bee
Amel\GB52437
Apis mellifera
Western honey bee
Amel\Iap2
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22184
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22183
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11756
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25654
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19360
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25238
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22182
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19359
Bombus terrestris
Buff-tailed bumblebee
Bter\15201463
Bombus terrestris
Buff-tailed bumblebee
Bter\15212198
Bombus terrestris
Buff-tailed bumblebee
Bter\15207755
Bombus terrestris
Buff-tailed bumblebee
Bter\15212197
Bombus terrestris
Buff-tailed bumblebee
Bter\15201753
Bombus terrestris
Buff-tailed bumblebee
Bter\15212191
Bombus terrestris
Buff-tailed bumblebee
Bter\15202387
Bombus terrestris
Buff-tailed bumblebee
Bter\15201247
Bombus terrestris
Buff-tailed bumblebee
Bter\15201445
Linepithema humile
Argentine ant
Lhum\LH21939
Linepithema humile
Argentine ant
Lhum\LH21940
Linepithema humile
Argentine ant
Lhum\LH21936
Linepithema humile
Argentine ant
Lhum\LH20764
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002935
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002934
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009566
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018431
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009562
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016254
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014709
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG033308
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03889
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03892
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00224
Tribolium castaneum
Red flour beetle
Tcas\TC001192
Tribolium castaneum
Red flour beetle
Tcas\TC001189
Pediculus humanus
Human body louse
Phum\PHUM080100
Pediculus humanus
Human body louse
Phum\PHUM253740
Rhodnius prolixus
Kissing bug
Rpro\RPRC007068
Rhodnius prolixus
Kissing bug
Rpro\RPRC001809
Cimex lectularius
Bed bug
Clec\CLEC000779
Cimex lectularius
Bed bug
Clec\CLEC003241
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI088105
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009069
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004833
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009246
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000445
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13218
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13895
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14414
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13894
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06782
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0747 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003245
Strigamia maritima
European centipede
Smar\SMAR004880
Strigamia maritima
European centipede
Smar\SMAR012635
Strigamia maritima
European centipede
Smar\SMAR000969
Strigamia maritima
European centipede
Smar\SMAR015763
Strigamia maritima
European centipede
Smar\SMAR014324
Strigamia maritima
European centipede
Smar\SMAR002085
Ixodes scapularis
Black-legged tick
Isca\ISCW010694
Ixodes scapularis
Black-legged tick
Isca\ISCW015499
Ixodes scapularis
Black-legged tick
Isca\ISCW003136
Ixodes scapularis
Black-legged tick
Isca\ISCW004187
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78917.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65428.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g07750
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g02900
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g12100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03830
Tetranychus urticae
Two-spotted spider mite
Turt\tetur59g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09840
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g10290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur58g00080
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g00890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g01110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g01630
Tetranychus urticae
Two-spotted spider mite
Turt\tetur45g00100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g07570
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g04890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g09000
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g01500
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09850
Tetranychus urticae
Two-spotted spider mite
Turt\tetur39g00770
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g07740
Tetranychus urticae
Two-spotted spider mite
Turt\tetur45g00130
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g05870
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00960
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03410
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g10150
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g00030
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_58422
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_256692
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_204003
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_95322
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CXH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Birc2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Birc2c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Iap1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2977
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Birc1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Birc2a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Birc2c_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000033
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024725
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024088
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004738
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009947
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019591
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005071
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002533
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004216
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020324
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011291
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000258
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016659
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008491
Gallus gallus
Domestic chicken
Ggal\ITA
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005762
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Diap1
6 of 10
Det
4 of 10
Bruce
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    XIAP; X-linked inhibitor of apoptosis
    model of  X-linked lymphoproliferative syndrome 2
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Diap2GMR.PH
    ameliorates  tauopathy
    modeled by Hsap\MAPTGMR.Ex.PJ
    (Jackson et al., 2002)
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BIRC2; baculoviral IAP repeat containing 2
    14 of 15
    601712
        BIRC3; baculoviral IAP repeat containing 3
        13 of 15
        601721
            XIAP; X-linked inhibitor of apoptosis
            10 of 15
            300079
             
            BIRC7; baculoviral IAP repeat containing 7
            8 of 15
            605737
                BIRC8; baculoviral IAP repeat containing 8
                7 of 15
                    BIRC5; baculoviral IAP repeat containing 5
                    4 of 15
                    603352
                        NAIP; NLR family apoptosis inhibitory protein
                        4 of 15
                        600355
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Show neighbor-neighbor interactions:
                            Select Layout:
                            Legend:
                            Protein
                            RNA
                            Selected Interactor(s)
                            Interactions Browser
                            View in Interactions Browser
                            Please see the Physical Interaction reports below for full details
                            protein-protein
                            Physical Interaction
                            Assay
                            References
                            Diap2 - CG3262
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - Coprox
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - Dredd
                            anti tag coimmunoprecipitation, anti tag western blot, pull down
                            (Guntermann et al., 2015, Meinander et al., 2012, Guntermann and Foley, 2011)
                            Diap2 - Drice
                            anti tag coimmunoprecipitation, western blot
                            (Ribeiro et al., 2007, Leulier et al., 2006)
                            Diap2 - EndoG
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - EndoGI
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - Fadd
                            anti tag coimmunoprecipitation, anti tag western blot
                            (Guntermann et al., 2015, Meinander et al., 2012, Guntermann and Foley, 2011)
                            Diap2 - Gsc
                            two hybrid
                            (Hu et al., 2017.6.13)
                            Diap2 - HtrA2
                            protease assay, autoradiography, pull down
                            (Khan et al., 2008)
                            Diap2 - Jafrac2
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - Mpcp2
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - PGRP-LC
                            anti tag coimmunoprecipitation, anti tag western blot
                            (Neyen et al., 2016)
                            Diap2 - Su(P)
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - grim
                            pull down, autoradiography
                            (Khan et al., 2008)
                            Diap2 - hid
                            pull down, western blot, anti tag western blot
                            (Ribeiro et al., 2007, Leulier et al., 2006)
                            Diap2 - imd
                            pull down, anti tag western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
                            (Meinander et al., 2012, Paquette et al., 2010)
                            Diap2 - mtDNA-helicase
                            experimental knowledge based
                            (Guruharsha et al., 2011)
                            Diap2 - rpr
                            pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot
                            (Ribeiro et al., 2007, Vucic et al., 1997)
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            esyN Network Key:
                            Suppression
                            Enhancement
                            View in Interactions Browser
                            Please look at the allele data for full details of the genetic interactions
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            AIF
                            suppressible
                            Diap2
                            (Joza et al., 2008)
                            aos
                            suppressible
                            Diap2
                            (Sawamoto et al., 1998)
                            Diap1
                            suppressible
                            Diap2
                            (Ribeiro et al., 2007, Leulier et al., 2006)
                            Dref
                            suppressible
                            Diap2
                            (Hirose et al., 2001)
                            Dronc
                            suppressible
                            Diap2
                            (Quinn et al., 2000)
                            grim::rpr
                            suppressible
                            Diap2
                            (Wing et al., 2001)
                            grim
                            suppressible
                            Diap2
                            (Wing et al., 2001)
                            hid
                            suppressible
                            Diap2
                            (Wing et al., 1998, Hay et al., 1995)
                            Rac1
                            suppressible
                            Diap2
                            (Geisbrecht and Montell, 2004)
                            Rfx2
                            suppressible
                            Diap2
                            (Otsuki et al., 2004)
                            rpr
                            suppressible
                            Diap2
                            (Wing et al., 1998, Hay et al., 1995)
                            Syn2
                            suppressible
                            Diap2
                            (Nagai et al., 2010)
                            External Data
                            Subunit Structure (UniProtKB)
                            Interacts with the caspase Strica (PubMed:11550090). Interacts (via BIR2 domain) with rpr and grim (PubMed:18166655). Interacts (via the BIR2 and BIR3 domains) with hid (PubMed:18166655). Interacts (via BIR3 domain) with Drice (PubMed:18166655). Interacts with Dredd; likely to bind Dredd simultaneously with Fadd to form a trimeric complex (PubMed:22549468).
                            (UniProt, Q24307 )
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                            MIST (genetic) - An integrated Molecular Interaction Database
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Pathways
                            Gene Group - Pathway Membership (FlyBase)
                            Imd Signaling Pathway Core Components -
                            The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
                            External Data
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            2R
                            Recombination map
                            2-76
                            Cytogenetic map
                            52D2-52D2
                            Sequence location
                            2R:15,932,170..15,934,825 [-]
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            52D2-52D2
                            Limits computationally determined from genome sequence between P{lacW}l(2)k02205k02205&P{PZ}sli05248 and P{lacW}ATPCLk09217
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            52D1-52D2
                            (Hay, 1996.1.5)
                            52D-52D
                            (determined by in situ hybridisation)
                            (Duckett et al., 1996)
                            52D1-52D2
                            (determined by in situ hybridisation)
                            (Hay et al., 1995)
                            Experimentally Determined Recombination Data
                            Location
                            2-76
                            (FlyBase, 2016)
                            2-80.0
                            (Comeron et al., 2012)
                            2-
                            (Hay, 1996.1.5)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (8)
                            Genomic Clones (20)
                            cDNA Clones (62)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequences
                            BDGP DGC clones
                            Other clones
                            Drosophila Genomics Resource Center cDNA clones

                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                            cDNA Clones, End Sequenced (ESTs)
                            BDGP DGC clones
                            Other clones
                            RNAi and Array Information
                            Linkouts
                            DRSC - Results frm RNAi screens
                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                            Antibody Information
                            Laboratory Generated Antibodies
                             
                            polyclonal
                            (Leulier et al., 2006)
                            Commercially Available Antibodies
                             
                            Other Information
                            Relationship to Other Genes
                            Source for database identify of
                            Source for identity of: Diap2 Iap2
                            (Steller et al., 2014.7.9)
                            Source for database merge of
                            Additional comments
                            Changed from 'Iap2' to 'Diap2' to reflect common usage in the literature.
                            (Steller et al., 2014.7.9)
                            Other Comments
                            RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli when assayed in S2 cells. This effect is independent of ecdysone. Iap2 functions downstream of imd in the fat body, as shown by the ability of Iap2 dsRNA to inhibit transcriptional activation of Dpt by imd. Tab2 RNAi fails to prevent AttA activation by Iap2, indicating that Tab2 is upstream of Iap2 in the imd signalling pathway.
                            (Kleino et al., 2005)
                            Iap2 may be involved in Rel nuclear localization.
                            (Kleino et al., 2005)
                            The product of Iap2 can inhibit mammalian cell death induced by overexpression of caspases 1 and 2.
                            (Hawkins et al., 1998)
                            The Iap2 protein associates with the tkv receptor in vivo.
                            (Oeda et al., 1998)
                            Expression of death inducers rpr and W and the repression of death inhibitor Iap2 correlates with the onset of histolysis in the larval salivary gland, suggesting that programmed cell death may be coordinated by both inductive and repressive mechanisms.
                            (Jiang et al., 1997)
                            Drosophila homolog of baculovirus iap is molecularly cloned.
                            (Duckett et al., 1996)
                            The conservation of IAPs from humans to Drosophila suggests that they are important for the regulation of apoptosis.
                            (Liston et al., 1996)
                            Origin and Etymology
                            Discoverer
                            Etymology
                            Identification
                            External Crossreferences and Linkouts ( 67 )
                            Sequence Crossreferences
                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                            Other crossreferences
                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                            Flygut - An atlas of the Drosophila adult midgut
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                            InterPro - A database of protein families, domains and functional sites
                            KEGG Genes - Molecular building blocks of life in the genomic space.
                            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                            modMine - A data warehouse for the modENCODE project
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DPiM - Drosophila Protein interaction map
                            DroID - A comprehensive database of gene and protein interactions.
                            DRSC - Results frm RNAi screens
                            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                            FlyMine - An integrated database for Drosophila genomics
                            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                            MIST (genetic) - An integrated Molecular Interaction Database
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Synonyms and Secondary IDs (28)
                            Reported As
                            Symbol Synonym
                            CG8293
                            (Hosono et al., 2015, Ni et al., 2011.7.19, Ying et al., 2011, Keleman et al., 2009.8.5, Huh et al., 2007, Kleino et al., 2005, Labourier et al., 2002)
                            D-IAP2
                            (Deveraux and Reed, 1999, Miller, 1999)
                            D-iap2
                            (Vucic et al., 1998, Vucic et al., 1997, Vucic et al., 1997)
                            DIAP
                            (Ziraldo and Ma, 2015, Finelli et al., 2002, White, 1999, Baird, 1996.1.16)
                            DIAP-2
                            (Bergmann et al., 2003, Jackson et al., 2002, Wang, 2001, Massagué and Chen, 2000, Zapata et al., 2000, Meier and Evan, 1998)
                            DIAP2
                            (Aalto et al., 2019, Goto et al., 2018, Zhang et al., 2016, Aparicio et al., 2013, Rallis et al., 2013, Yeh and Bratton, 2013, Darding and Meier, 2012, Eleftherianos and Castillo, 2012, Vandenabeele and Bertrand, 2012, Kuranaga, 2011, Bader et al., 2010, Nagai et al., 2010, Nezis et al., 2010, Paquette et al., 2010, Cronin et al., 2009, Ertürk-Hasdemir et al., 2009, Khan et al., 2008, Lhocine et al., 2008, Herman-Bachinsky et al., 2007, Ribeiro et al., 2007, Ribeiro et al., 2007, Leulier et al., 2006, Anderson et al., 2005, Dotto and Silke, 2004, Geisbrecht and Montell, 2004, Otsuki et al., 2004, Renault et al., 2004, Shiozaki and Shi, 2004, Yeo and Gautier, 2004, Holcik, 2002, Holcik, 2002, Igaki et al., 2002, Jackson et al., 2002, Martin, 2002, Srinivasula et al., 2002, Tenev et al., 2002, Zimmermann et al., 2002, Doumanis et al., 2001, Hirose et al., 2001, Silke and Vaux, 2001, Hawkins et al., 2000, Igaki et al., 2000, Meier et al., 2000, Ohno et al., 2000, Reed and Bischoff, 2000, Takatsu et al., 2000, Vernooy et al., 2000, Vernooy et al., 2000, Vernooy et al., 2000, Abrams, 1999, Vaux and Korsmeyer, 1999, Foley and Cooley, 1998, Kaiser et al., 1998, LaCasse et al., 1998, Oeda et al., 1998, Wing and Nambu, 1998, Clem and Duckett, 1997, Harvey et al., 1997, Jiang et al., 1997, McCall and Steller, 1997, Chinnaiyan and Dixit, 1996, Hay, 1996.1.5, Hay et al., 1995)
                            DIAPII
                            (Anderson et al., 2005)
                            DIHA
                            (Hawkins et al., 1998, LaCasse et al., 1998, Uren et al., 1996, Puls, 1995.10.17)
                            Diap
                            Diap-2
                            (Arya and White, 2015)
                            Diap2
                            (Chen et al., 2017, Hu et al., 2017.6.13, Tavignot et al., 2017, Transgenic RNAi Project members, 2017-, Kuleesha et al., 2016, Nakazawa et al., 2016, Steller et al., 2014.7.9, Rallis et al., 2013, Meinander et al., 2012, Ying et al., 2011, Xu et al., 2009, Garcia-Lopez et al., 2008, Joza et al., 2008, Vicente-Crespo et al., 2008, Kuranaga and Miura, 2007, Hay et al., 2004, Kumar and Cakouros, 2004, Kramer et al., 2003, Richardson and Kumar, 2002, Kumar, 2000, Tittel and Steller, 2000, Kanuka et al., 1999, Uren et al., 1998)
                            Diha
                            IAP
                            (Nakayama et al., 2000, Conlan and Raff, 1999)
                            IAP2
                            (Galenza and Foley, 2019, Kleino and Silverman, 2014, Fukuyama et al., 2013, Yang et al., 2013, Waterhouse et al., 2007, Gesellchen et al., 2005)
                            Iap2
                            (Lee et al., 2016, Guntermann et al., 2015, Huang et al., 2015, Abnave et al., 2014, Myllymäki et al., 2014, Taylor et al., 2014, Valanne, 2014, Japanese National Institute of Genetics, 2012.5.21, Du et al., 2011, Valanne et al., 2011, Ying et al., 2011, Blanco et al., 2010, Guenin et al., 2010, Valanne et al., 2010, Zsindely et al., 2009, MacIntyre, 2007.8.30, Valanne et al., 2007, Jordan et al., 2005, Terashima and Bownes, 2005)
                            Ilp
                            dIAP
                            (White, 2000)
                            dIAP2
                            (Neyen et al., 2016, Aparicio et al., 2013, Gistelinck et al., 2012, Igboin et al., 2012, Guntermann and Foley, 2011, Bond and Foley, 2009, Silverman et al., 2008, Rawls et al., 2007, Bangs et al., 2000)
                            dILP
                            (Grewal, 2012, LaCasse et al., 1998, Duckett et al., 1996)
                            diap2
                            (Jonchère et al., 2017, Verma and Tapadia, 2015, Verma and Tapadia, 2014, Lee et al., 2013, Verma and Tapadia, 2012, Paquette et al., 2010, Huh et al., 2007, Ribeiro et al., 2007, Wu and Silverman, 2007, Leulier et al., 2006, Leulier et al., 2006, Yin and Thummel, 2004, Di Fruscio et al., 2003, Gorski and Marra, 2002, Harvey et al., 2001, Lee and Baehrecke, 2001, Buszczak and Segraves, 2000, Colussi et al., 2000, Hsu and Schulz, 2000, Jiang et al., 2000, Pecasse et al., 2000, Quinn et al., 2000, Kanuka et al., 1999, Thummel et al., 1999, Bergmann et al., 1998, Sawamoto et al., 1998, Jiang et al., 1997)
                            Name Synonyms
                            Death-associated inhibitor of apoptosis 2
                            (Steller et al., 2014.7.9)
                            Drosophila inhibitor of apoptosis 2
                            (Paquette et al., 2010)
                            Drosophila melanogaster inhibitor of apoptosis 2
                            (Ribeiro et al., 2007)
                            IAP-like protein
                            (Duckett et al., 1996, Duckett, 1995.7.26)
                            Inhibitor of Apoptosis Protein 2
                            (Gesellchen et al., 2005)
                            Inhibitor of apoptosis 2
                            inhibitor of apoptosis 2
                            (Valanne et al., 2010, Terashima and Bownes, 2005)
                            inhibitor of apoptosis protein 2
                            (Fukuyama et al., 2013)
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