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Gene Dmel\Nap1

General Information
Symbol	Dmel\Nap1	Species	D. melanogaster
Name	Nucleosome assembly protein 1	Annotation symbol	CG5330
Feature type	protein_coding_gene	FlyBase ID	FBgn0015268
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	NAP-1, dNAP-1, dNAP1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A9-60A9	Sequence location	2R:19,792,698..19,794,837 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleosome assembly protein 1 is referred to in FlyBase by the symbol Dmel\Nap1 (CG5330, FBgn0015268). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone binding. There is experimental evidence that it is involved in the biological process: regulation of transcription, DNA-dependent; nucleosome assembly. 26 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Nucleosome assembly protein (NAP). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1626785_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nap1. Gene sequence location is 2R:19792698..19794837.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN22031 HFA04626
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A9-60A9   Limits computationally determined from genome sequence between P{lacW}kenk11035&P{EP}CG17658EP730 and P{EP}TalEP489&P{EP}CG3065EP316
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A5-60A6   (determined by in situ hybridisation)   (Ito et al., 1996)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nap1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nap1-RA FBtr0072219  NM_057780   1381   370 Nap1-RB FBtr0305989     1393   370 Nap1-RC FBtr0305990     1300   370
Additional Transcript Data & Comments
Reported size (kB)	1.5 (northern blot) (Ito et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nap1-PA   FBpp0072128   42.8   370   4.40     NP_477128   AAF47097 Nap1-PB   FBpp0297131   42.8   370   4.40       Nap1-PC   FBpp0297132   42.8   370   4.40
Additional Polypeptide Data & Comments
Reported size (kDa)	370 (aa); 56 (kD observed) (Ito et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nucleosome assembly protein (NAP) (IPR002164)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141891   AA263293   AA264544   AA441646   AA567139   AA694745   AA694860   AA695543   AA696260   AA697090   AA735585   AA736000   AA736043   AA801645   AA802301   AA802550   AA820755   AA820824   AA821089   AA941486   AA942297   AA948798   AE013599 AAF47097   AC004347   AC005267   AI107637   AI108895   AI109143   AI109183   AI110044   AI237929   AI257836   AI258376   AI259303   AI292601   AI293583   AI297223   AI389701   AI403976   AI455168   AI514505   AI515007   AI516857   AI518775   AI518789   AI520008   AI532303   AI542432   AI542846   AI543094   AY232036   BF503447   BF503990   BG637090   BG637131   BG640093   BG640849   BH615113   BI162639   BI162640   BI213219   BI230256   BI243036   BI352453   BI353952   BI354131   BI563445   BI563784   BI564051   BI564205   BI565523   BI566247   BI566708   BI567037   BI567203   BI567366   BI567603   BI569718   BI571143   BI571165   BI571571   BI571615   BI571622   BI571631   BI571693   BI572203   BI572460   BI572488   BI572576   BI572587   BI572601   BI572650   BI572686   BI572764   BI573026   BI573172   BI573929   BI574403   BI576390   BI576463   BI576616   BI576806   BI581470   BI581510   BI581704   BI582134   BI582166   BI583337   BI584117   BI584541   BI584819   BI584934   BI584949   BI585807   BI587298   BI588150   BI588847   BI588895   BI589084   BI589712   BI589955   BI591156   BI591302   BI591354   BI591365   BI591374   BI591449   BI591553   BI591769   BI592574   BI592911   BI593504   BI604655   BI604667   BI605974   BI606088   BI606107   BI606187   BI606860   BI609040   BI609457   BI610205   BI610309   BI610576   BI611259   BI614544   BI614986   BI615929   BI616618   BI617931   BI618004   BI618866   BI619890   BI620935   BI621135   BI621292   BI621465   BI621577   BI622960   BI623947   BI624239   BI624432   BI624480   BI625153   BI626354   BI626626   BI627162   BI627392   BI627916   BI629378   BI629720   BI629949   BI631079   BI631341   BI632884   BI633407   BI633958   BI634900   BI635107   BI636392   BI636453   BI636929   BI638781   BI639618   BI640439   BI640882   BI641718   BP541563   BP542020   BP545534   BP551371   BP552988   BP554045   BQ103522   BQ103717   BT001479 AAN71234   BT120094   CA805399   CK131985   CK131991   CK662446   CL610220   CO155104   CO155120   CO191687   CO193102   CO266690   CO267668   CO278865   CO281162   CO294025   CO298900   CO311091   CO311730   CO313731   CO316982   CO332747   CO336728   CO337251   CO338721   CZ469701   CZ484627   CZ484628   CZ488907   EC076285   EC088035   EC090654   EC201429   EC205605   EC209878   EC222118   EC222143   EC225192   EC238574   EC240089   EC244962   EC261702   EC261980   EC264175   EC265172   EC267456   EL883169   EL883409   EV576391   EV577445   EV580460   EV583964   EV584339   EV585862   EV585979   EV586874   EV593333   EV595240   EV595346   EV599490   EV599540   EV599910   GH756364   GH771760   GH805653   GH822672   GH830511   GH832705   GH837970   GH849667   GH852811   GH856305   GH862461   GH876462   GH881561   GH882056   GH890925   GH894062   GH898030   GH907457   GH916808   GH916911   GH926950   U39553 AAB07898
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24150 Q9W1G7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Ito et al., 1996) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Ito et al., 1996, Ito et al., 1999)
Additional Descriptive Data
	In early Drosophila embryos, Nap1 protein is present in the nucleus and cytoplasm during S phase, and is mainly cytoplasmic during G2-phase. (Ito et al., 1996) Nlp and Nap1 proteins are both expressed at highest levels in early embryos, and at reduced but significant levels in larval through adult stages. (Ito et al., 1996) Nap1 protein is present at high levels throughout development except in adult males where it is present at lower levels. (Ito et al., 1999)
Marker for
Subcellular Localization
CV Term	nucleus cytoplasm (Ito et al., 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015268    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015268 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015268 expression level Developmental Stage   Expression Level embryo 00-02hr    42018 embryo 02-04hr    9912 embryo 04-06hr    10748 embryo 06-08hr    13946 embryo 08-10hr    13754 embryo 10-12hr    12646 embryo 12-14hr    9300 embryo 14-16hr    7541 embryo 16-18hr    7091 embryo 18-20hr    9374 embryo 20-22hr    17778 embryo 22-24hr    16580 larva L1    36856 larva L2    20949 larva L3 12hr old    19054 larva L3 puffstage 1-2    11502 larva L3 puffstage 3-6    13134 larva L3 puffstage 7-9    14480 white prepupae new    12618 white prepupae 12hr    12502 white prepupae 24hr    11145 pupae 2d postWPP    8435 pupae 3d postWPP    7145 pupae 4d postWPP    8031 adult male 01day    8397 adult male 05day    10703 adult male 30day    10463 adult female 01day    39475 adult female 05day    55461 adult female 30day    52985 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (42018) embryo 02-04hr  (9912) embryo 04-06hr  (10748) embryo 06-08hr  (13946) embryo 08-10hr  (13754) embryo 10-12hr  (12646) embryo 12-14hr  (9300) embryo 14-16hr  (7541) embryo 16-18hr  (7091) embryo 18-20hr  (9374) embryo 20-22hr  (17778) embryo 22-24hr  (16580) larva L1  (36856) larva L2  (20949) larva L3 12hr old  (19054) larva L3 puffstage 1-2  (11502) larva L3 puffstage 3-6  (13134) larva L3 puffstage 7-9  (14480) white prepupae new  (12618) white prepupae 12hr  (12502) white prepupae 24hr  (11145) pupae 2d postWPP  (8435) pupae 3d postWPP  (7145) pupae 4d postWPP  (8031) adult male 01day  (8397) adult male 05day  (10703) adult male 30day  (10463) adult female 01day  (39475) adult female 05day  (55461) adult female 30day  (52985) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42018) embryo 02-04hr  (9912) embryo 04-06hr  (10748) embryo 06-08hr  (13946) embryo 08-10hr  (13754) embryo 10-12hr  (12646) embryo 12-14hr  (9300) embryo 14-16hr  (7541) embryo 16-18hr  (7091) embryo 18-20hr  (9374) embryo 20-22hr  (17778) embryo 22-24hr  (16580) larva L1  (36856) larva L2  (20949) larva L3 12hr old  (19054) larva L3 puffstage 1-2  (11502) larva L3 puffstage 3-6  (13134) larva L3 puffstage 7-9  (14480) white prepupae new  (12618) white prepupae 12hr  (12502) white prepupae 24hr  (11145) pupae 2d postWPP  (8435) pupae 3d postWPP  (7145) pupae 4d postWPP  (8031) adult male 01day  (8397) adult male 05day  (10703) adult male 30day  (10463) adult female 01day  (39475) adult female 05day  (55461) adult female 30day  (52985) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (42018) embryo 02-04hr    9912 embryo 04-06hr  10748 embryo 06-08hr  (13946) embryo 08-10hr  (13754) embryo 10-12hr  (12646) embryo 12-14hr    9300 embryo 14-16hr    7541 embryo 16-18hr    7091 embryo 18-20hr    9374 embryo 20-22hr  (17778) embryo 22-24hr  (16580) larva L1  (36856) larva L2  (20949) larva L3 12hr old  (19054) larva L3 puffstage 1-2  (11502) larva L3 puffstage 3-6  (13134) larva L3 puffstage 7-9  (14480) white prepupae new  (12618) white prepupae 12hr  (12502) white prepupae 24hr  (11145) pupae 2d postWPP    8435 pupae 3d postWPP    7145 pupae 4d postWPP    8031 adult male 01day    8397 adult male 05day  10703 adult male 30day  10463 adult female 01day  (39475) adult female 05day  (55461) adult female 30day  (52985) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42018 embryo 02-04hr    9912 embryo 04-06hr    10748 embryo 06-08hr    13946 embryo 08-10hr    13754 embryo 10-12hr    12646 embryo 12-14hr    9300 embryo 14-16hr    7541 embryo 16-18hr    7091 embryo 18-20hr    9374 embryo 20-22hr    17778 embryo 22-24hr    16580 larva L1    36856 larva L2    20949 larva L3 12hr old    19054 larva L3 puffstage 1-2    11502 larva L3 puffstage 3-6    13134 larva L3 puffstage 7-9    14480 white prepupae new    12618 white prepupae 12hr    12502 white prepupae 24hr    11145 pupae 2d postWPP    8435 pupae 3d postWPP    7145 pupae 4d postWPP    8031 adult male 01day    8397 adult male 05day    10703 adult male 30day    10463 adult female 01day    39475 adult female 05day    55461 adult female 30day    52985 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015268 expression level Developmental Stage   Expression Level embryo 00-02hr    42018 embryo 02-04hr    9912 embryo 04-06hr    10748 embryo 06-08hr    13946 embryo 08-10hr    13754 embryo 10-12hr    12646 embryo 12-14hr    9300 embryo 14-16hr    7541 embryo 16-18hr    7091 embryo 18-20hr    9374 embryo 20-22hr    17778 embryo 22-24hr    16580 larva L1    36856 larva L2    20949 larva L3 12hr old    19054 larva L3 puffstage 1-2    11502 larva L3 puffstage 3-6    13134 larva L3 puffstage 7-9    14480 white prepupae new    12618 white prepupae 12hr    12502 white prepupae 24hr    11145 pupae 2d postWPP    8435 pupae 3d postWPP    7145 pupae 4d postWPP    8031 adult male 01day    8397 adult male 05day    10703 adult male 30day    10463 adult female 01day    39475 adult female 05day    55461 adult female 30day    52985 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (42018) embryo 02-04hr  (9912) embryo 04-06hr  (10748) embryo 06-08hr  (13946) embryo 08-10hr  (13754) embryo 10-12hr  (12646) embryo 12-14hr  (9300) embryo 14-16hr  (7541) embryo 16-18hr  (7091) embryo 18-20hr  (9374) embryo 20-22hr  (17778) embryo 22-24hr  (16580) larva L1  (36856) larva L2  (20949) larva L3 12hr old  (19054) larva L3 puffstage 1-2  (11502) larva L3 puffstage 3-6  (13134) larva L3 puffstage 7-9  (14480) white prepupae new  (12618) white prepupae 12hr  (12502) white prepupae 24hr  (11145) pupae 2d postWPP  (8435) pupae 3d postWPP  (7145) pupae 4d postWPP  (8031) adult male 01day  (8397) adult male 05day  (10703) adult male 30day  (10463) adult female 01day  (39475) adult female 05day  (55461) adult female 30day  (52985) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42018) embryo 02-04hr  (9912) embryo 04-06hr  (10748) embryo 06-08hr  (13946) embryo 08-10hr  (13754) embryo 10-12hr  (12646) embryo 12-14hr  (9300) embryo 14-16hr  (7541) embryo 16-18hr  (7091) embryo 18-20hr  (9374) embryo 20-22hr  (17778) embryo 22-24hr  (16580) larva L1  (36856) larva L2  (20949) larva L3 12hr old  (19054) larva L3 puffstage 1-2  (11502) larva L3 puffstage 3-6  (13134) larva L3 puffstage 7-9  (14480) white prepupae new  (12618) white prepupae 12hr  (12502) white prepupae 24hr  (11145) pupae 2d postWPP  (8435) pupae 3d postWPP  (7145) pupae 4d postWPP  (8031) adult male 01day  (8397) adult male 05day  (10703) adult male 30day  (10463) adult female 01day  (39475) adult female 05day  (55461) adult female 30day  (52985) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (42018) embryo 02-04hr    9912 embryo 04-06hr  10748 embryo 06-08hr  13946 embryo 08-10hr  13754 embryo 10-12hr  12646 embryo 12-14hr    9300 embryo 14-16hr    7541 embryo 16-18hr    7091 embryo 18-20hr    9374 embryo 20-22hr  17778 embryo 22-24hr  16580 larva L1  (36856) larva L2  (20949) larva L3 12hr old  19054 larva L3 puffstage 1-2  11502 larva L3 puffstage 3-6  13134 larva L3 puffstage 7-9  14480 white prepupae new  12618 white prepupae 12hr  12502 white prepupae 24hr  11145 pupae 2d postWPP    8435 pupae 3d postWPP    7145 pupae 4d postWPP    8031 adult male 01day    8397 adult male 05day  10703 adult male 30day  10463 adult female 01day  (39475) adult female 05day  (55461) adult female 30day  (52985) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42018 embryo 02-04hr    9912 embryo 04-06hr    10748 embryo 06-08hr    13946 embryo 08-10hr    13754 embryo 10-12hr    12646 embryo 12-14hr    9300 embryo 14-16hr    7541 embryo 16-18hr    7091 embryo 18-20hr    9374 embryo 20-22hr    17778 embryo 22-24hr    16580 larva L1    36856 larva L2    20949 larva L3 12hr old    19054 larva L3 puffstage 1-2    11502 larva L3 puffstage 3-6    13134 larva L3 puffstage 7-9    14480 white prepupae new    12618 white prepupae 12hr    12502 white prepupae 24hr    11145 pupae 2d postWPP    8435 pupae 3d postWPP    7145 pupae 4d postWPP    8031 adult male 01day    8397 adult male 05day    10703 adult male 30day    10463 adult female 01day    39475 adult female 05day    55461 adult female 30day    52985 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015268    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015268 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015268 expression level Tissue   Expression Level Larval Central Nervous System    1307.7 Larval Midgut    564.1 Larval Hindgut    1063.2 Larval Malpighian Tubules    418.4 Larval Fat Body    641.2 Larval Salivary Gland    1451.4 Larval Trachea    2333.25 Larval Carcass    1182.825 Adult Head    1281.1 Adult Eye    2010.45 Adult Brain    744.7 Adult Thoracic-Abdominal Ganglion    766.4 Adult Crop    1197.7 Adult Midgut    844 Adult Hindgut    1365.3 Adult Malpighian Tubules    852 Adult Fat Body    2228.3 Adult Salivary Gland    1472.5 Adult Heart    1826.925 Adult VirginFemale Spermatheca    1003.2 Adult InseminatedFemale Spermatheca    1197.9 Adult Ovary    2046.9 Adult Testis    232.2 Adult Male Accessory Gland    1605.5 Adult Carcass    1315.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1307.7) Larval Midgut  (564.1) Larval Hindgut  (1063.2) Larval Malpighian Tubules    418.4 Larval Fat Body  (641.2) Larval Salivary Gland  (1451.4) Larval Trachea  (2333.25) Larval Carcass  (1182.825) Adult Head  (1281.1) Adult Eye  (2010.45) Adult Brain  (744.7) Adult Thoracic-Abdominal Ganglion  (766.4) Adult Crop  (1197.7) Adult Midgut  (844) Adult Hindgut  (1365.3) Adult Malpighian Tubules  (852) Adult Fat Body  (2228.3) Adult Salivary Gland  (1472.5) Adult Heart  (1826.925) Adult VirginFemale Spermatheca  (1003.2) Adult InseminatedFemale Spermatheca  (1197.9) Adult Ovary  (2046.9) Adult Testis    232.2 Adult Male Accessory Gland  (1605.5) Adult Carcass  (1315.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1307.7) Larval Midgut    564.1 Larval Hindgut  1063.2 Larval Malpighian Tubules    418.4 Larval Fat Body    641.2 Larval Salivary Gland  (1451.4) Larval Trachea  (2333.25) Larval Carcass  (1182.825) Adult Head  (1281.1) Adult Eye  (2010.45) Adult Brain    744.7 Adult Thoracic-Abdominal Ganglion    766.4 Adult Crop  (1197.7) Adult Midgut    844 Adult Hindgut  (1365.3) Adult Malpighian Tubules    852 Adult Fat Body  (2228.3) Adult Salivary Gland  (1472.5) Adult Heart  (1826.925) Adult VirginFemale Spermatheca  1003.2 Adult InseminatedFemale Spermatheca  (1197.9) Adult Ovary  (2046.9) Adult Testis    232.2 Adult Male Accessory Gland  (1605.5) Adult Carcass  (1315.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1307.7 Larval Midgut    564.1 Larval Hindgut    1063.2 Larval Malpighian Tubules    418.4 Larval Fat Body    641.2 Larval Salivary Gland    1451.4 Larval Trachea    2333.25 Larval Carcass    1182.825 Adult Head    1281.1 Adult Eye    2010.45 Adult Brain    744.7 Adult Thoracic-Abdominal Ganglion    766.4 Adult Crop    1197.7 Adult Midgut    844 Adult Hindgut    1365.3 Adult Malpighian Tubules    852 Adult Fat Body    2228.3 Adult Salivary Gland    1472.5 Adult Heart    1826.925 Adult VirginFemale Spermatheca    1003.2 Adult InseminatedFemale Spermatheca    1197.9 Adult Ovary    2046.9 Adult Testis    232.2 Adult Male Accessory Gland    1605.5 Adult Carcass    1315.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015268 expression level Tissue   Expression Level Larval Central Nervous System    1307.7 Larval Midgut    564.1 Larval Hindgut    1063.2 Larval Malpighian Tubules    418.4 Larval Fat Body    641.2 Larval Salivary Gland    1451.4 Larval Trachea    2333.25 Larval Carcass    1182.825 Adult Head    1281.1 Adult Eye    2010.45 Adult Brain    744.7 Adult Thoracic-Abdominal Ganglion    766.4 Adult Crop    1197.7 Adult Midgut    844 Adult Hindgut    1365.3 Adult Malpighian Tubules    852 Adult Fat Body    2228.3 Adult Salivary Gland    1472.5 Adult Heart    1826.925 Adult VirginFemale Spermatheca    1003.2 Adult InseminatedFemale Spermatheca    1197.9 Adult Ovary    2046.9 Adult Testis    232.2 Adult Male Accessory Gland    1605.5 Adult Carcass    1315.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1307.7) Larval Midgut  564.1 Larval Hindgut  (1063.2) Larval Malpighian Tubules    418.4 Larval Fat Body  641.2 Larval Salivary Gland  (1451.4) Larval Trachea  (2333.25) Larval Carcass  (1182.825) Adult Head  (1281.1) Adult Eye  (2010.45) Adult Brain  744.7 Adult Thoracic-Abdominal Ganglion  766.4 Adult Crop  (1197.7) Adult Midgut  (844) Adult Hindgut  (1365.3) Adult Malpighian Tubules  (852) Adult Fat Body  (2228.3) Adult Salivary Gland  (1472.5) Adult Heart  (1826.925) Adult VirginFemale Spermatheca  (1003.2) Adult InseminatedFemale Spermatheca  (1197.9) Adult Ovary  (2046.9) Adult Testis    232.2 Adult Male Accessory Gland  (1605.5) Adult Carcass  (1315.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1307.7 Larval Midgut    564.1 Larval Hindgut  1063.2 Larval Malpighian Tubules    418.4 Larval Fat Body    641.2 Larval Salivary Gland  1451.4 Larval Trachea  (2333.25) Larval Carcass  1182.825 Adult Head  1281.1 Adult Eye  (2010.45) Adult Brain    744.7 Adult Thoracic-Abdominal Ganglion    766.4 Adult Crop  1197.7 Adult Midgut    844 Adult Hindgut  1365.3 Adult Malpighian Tubules    852 Adult Fat Body  (2228.3) Adult Salivary Gland  1472.5 Adult Heart  (1826.925) Adult VirginFemale Spermatheca  1003.2 Adult InseminatedFemale Spermatheca  1197.9 Adult Ovary  (2046.9) Adult Testis    232.2 Adult Male Accessory Gland  1605.5 Adult Carcass  1315.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1307.7 Larval Midgut    564.1 Larval Hindgut    1063.2 Larval Malpighian Tubules    418.4 Larval Fat Body    641.2 Larval Salivary Gland    1451.4 Larval Trachea    2333.25 Larval Carcass    1182.825 Adult Head    1281.1 Adult Eye    2010.45 Adult Brain    744.7 Adult Thoracic-Abdominal Ganglion    766.4 Adult Crop    1197.7 Adult Midgut    844 Adult Hindgut    1365.3 Adult Malpighian Tubules    852 Adult Fat Body    2228.3 Adult Salivary Gland    1472.5 Adult Heart    1826.925 Adult VirginFemale Spermatheca    1003.2 Adult InseminatedFemale Spermatheca    1197.9 Adult Ovary    2046.9 Adult Testis    232.2 Adult Male Accessory Gland    1605.5 Adult Carcass    1315.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1281.1   NA  Eye    2010.45   NA  Brain    744.7   1307.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    766.4   NA  Crop    1197.7   564.1  Midgut    844   1063.2  Hindgut    1365.3   418.4  Malpighian Tubules    852   641.2  Fat Body    2228.3   1451.4  Salivary Gland    1472.5   NA  Heart    1826.925   2333.25  Trachea    NA   NA  VirginFemale Spermatheca    1003.2   NA  InseminatedFemale Spermatheca    1197.9   NA  Ovary    2046.9   NA  Testis    232.2   NA  Male Accessory Gland    1605.5   1182.825  Carcass    1315.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015268 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5330-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Nap1 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Nap1KO1.3') Nap1KO1.5' lethal (with Nap1KO1.5') Nap1KO1.3' lethal (with Nap1KO2.3') Nap1KO2.5' lethal (with Nap1KO2.5') Nap1KO2.3' semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Nap1GD11609 viable Nap1EY08596 Nap1KG03959 Nap1KO5.3' Nap1KO5.5' viable (with Nap1KO6.3') Nap1KO6.5' viable (with Nap1KO6.5') Nap1KO6.3' Sterility Allele fertile Nap1EY08596 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Nap1GD11609 wild-type Nap1KG03959 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Nap1GD11609 trichogen cell, with Scer\GAL4pnr-MD237 Nap1GD11609
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of Nap1 Class Mutagen Stocks Known lesion Nap1c05041 piggyBac transposase 1 -- Nap1EY08596 P-element activity 1 -- Nap1f06242 piggyBac transposase 1 -- Nap1KG03959 P-element activity 1 -- Nap1KO1.3' recombination SCEI endonuclease FLPase 1 Yes Nap1KO1.5' recombination SCEI endonuclease FLPase 1 Yes Nap1KO2.3' recombination SCEI endonuclease FLPase 1 Yes Nap1KO2.5' recombination SCEI endonuclease FLPase 1 Yes Nap1NP6207 1 -- Nap1NP6266 1 -- Nap15-HA-1145 0 -- Nap1f02128 piggyBac transposase 0 -- Nap1KO3.3' recombination SCEI endonuclease FLPase 0 Yes Nap1KO3.5' recombination SCEI endonuclease FLPase 0 Yes Nap1KO4.3' recombination SCEI endonuclease FLPase 0 Yes Nap1KO4.5' recombination SCEI endonuclease FLPase 0 Yes Nap1KO5.3' recombination SCEI endonuclease FLPase 0 Yes Nap1KO5.5' recombination SCEI endonuclease FLPase 0 Yes Nap1KO6.3' recombination SCEI endonuclease FLPase 0 Yes Nap1KO6.5' recombination SCEI endonuclease FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nap1 Class Mutagen Stocks Known lesion Nap1GD11609 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nap1GL00370 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nap13xA.MtnA.T:SV5\V5 in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Nap14.3.Scer\SceI.RS in vitro construct 0 Yes Nap1KK101965 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Nap1MtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6080 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11609} NA P{KK101965} NA P{TRiP.GL00370} NA characterization construct P{FRT(whs.Nap14.3.Scer\SceI.RS)} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Nap1EY08596 NA miscellaneous insertions P{RS5}Nap15-HA-1145 NA P{SUPor-P}Nap1KG03959 NA PBac{PB}Nap1c05041 NA PBac{WH}Nap1f02128 NA PBac{WH}Nap1f06242 NA insertion of enhancer trap binary system P{GawB}Nap1NP6207 No P{GawB}Nap1NP6266 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
histone binding inferred from direct assay (Ito et al., 1996)
Biological Process
CV term Evidence References
nucleosome assembly inferred from direct assay (Ito et al., 1996, Ito et al., 1997) regulation of transcription, DNA-dependent inferred from direct assay (Ito et al., 1997)
Cellular Component
CV term Evidence References
NOT ACF complex inferred from direct assay (Ito et al., 1997) cytoplasm inferred from direct assay (Ito et al., 1996) nucleus inferred from direct assay (Ito et al., 1996)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
histone binding traceable author statement (Ito et al., 1997)
Biological Process
CV term Evidence References
nucleosome assembly inferred from sequence or structural similarity with Saccharomyces NAP1 (FlyBase, 1992-) non-traceable author statement (Ito, 1995.10.27)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nap1 allele Gene References Nap1KG03959 Acf1 (Fyodorov et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63390 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015268 DroID - A comprehensive database of gene and protein interactions. • FBgn0015268 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37798
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12054 Dere\GG19979 Dgri\GH20189 Dmoj\GI18847 Dper\GL10917 Dpse\GA18808 Dsec\GM15492 Dsim\GD24995 Dvir\GJ20453 Dwil\GK15855 Dyak\Nap1
Curated drosophilid orthologs	Dpse\GA18808   Dyak\Nap1
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005567-PB Aedes aegypti (mosquito) AGAP009639-PA Anopheles gambiae (mosquito) XP_623275.1 Apis mellifera (honey bee) XP_001950710.1 Acyrthosiphon pisum (pea aphid) At4g26110.1 Arabidopsis thaliana (wall cress) 30577 Batrachochytrium dendrobatidis (chytrid fungus) 126640 Branchiostoma floridae (lancelet) 96619 Branchiostoma floridae (lancelet) XP_001897013.1 Brugia malayi (roundworm nematode) BGIBMGA009249-PA Bombyx mori (silk worm) ENSBTAP00000027852 Bos taurus (bovine) ENSBTAP00000038468 Bos taurus (bovine) CAL0006351 Candida albicans (a form of yeast) CBP20078 Caenorhabditis briggsae (nematode) CE04306 Caenorhabditis elegans (worm) ENSCAFP00000015053 Canis familiaris (dog) CAGL0M05973g Candida glabrata (haploid yeast) Chro.40090 Cryptosporidium hominis (obligate parasite) ENSCINP00000018743 Ciona intestinalis (sea squirt) JA15083 Caenorhabditis japonica (nematode) cn05450 Cryptococcus neoformans (yeast-like fungus) cgd4_720 Cryptosporidium parvum (protozoan parasite) CPIJ015259 Culex pipens (mosquito) ENSCPOP00000017660 Cavia porcellus (guinea pig) 192162 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000011356 Ciona savignyi (sedentary tunicate) 163453 Capitella spl (polychaete worm) DDB0267102 Dictyostelium discoideum (amoeba) DEHA2C11792g Debaryomyces Hansenii (yeast) 299973 Daphnia pulex (daphnia) ENSDARP00000027102 Danio rerio (zebra fish) ENSECAP00000000167 Equus caballus (horse) XP_651305 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014675 Gymnopilus aculeatus (mushroom) ENSGALP00000016623 Gallus gallus (chicken) 110599 Hypsipyla robusta (cedar shoot borer) ENSP00000261182 Homo sapiens (human) ISCW005016-PA Ixodes scapularis (deer tick) KLLA0E15049g Kluyveromyces lactis (yeast) 103941 Lottia gigantea (owl limpet) LmjF31.1750 Leishmania major (virus) ENSMODP00000025597 Monodelphis domestica (gray opossum) ENSMMUP00000026595 Macaca mulatta (rhesus monkey) ENSMMUP00000039127 Macaca mulatta (rhesus monkey) ENSMUSP00000070068 Mus musculus (house mouse) 236778 Nematostella vectensis (starlet anemone) XP_001607381.1 Nasonia vitripennis (wasp) ENSOANP00000007428 Ornithorynchus anatinus (platypus) ENSORLP00000015211 Oryzias latipes (japanese killifish) LOC_Os06g05660.1 Oryza sativa (asian rice) 4059 Ostreococcus tauri (green alga) PFL0185c Plasmodium falciparum (protozoal parasite) PHUM000389-PA Pediculus humanus (human body louse) PP12272 Pristionchus pacificus (nematode) 111058 Physcomitrella patens (moss) ENSPPYP00000005453 Pongo pygmaeus (orangutan) 74957 Phytophthora ramorum (sudden oak death pathogen) 134487 Phytophthora sojae (root rot pathogen) 819264 Populus trichocarpa (black cottonwood) ENSPTRP00000008901 Pan troglodytes (chimpanzee) PVX_084230 Plasmodium vivax (protozoal parasite) ENSRNOP00000005286 Rattus norvegicus (norway rat) 4896510 Sorghum bicolor (sorghum) YKR048C Saccharomyces cerevisiae (budding yeast) Smp_023530 Schistosoma mansoni (trematode parasite) SPCC364.06 Schizosaccharomyces pombe (fission yeast) XP_001196396.1 Strongylocentrotus purpuratus (purple sea urchin) 32481 Trichoplax adhaerens (metazoa) TA04600 Theileria annulata (apicomplexan parasite) Tc00.1047053507031.29 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008224 Tetraodon nigroviridis (green spotted pufferfish) TP03_0447 Theileria parva (parasitic protozoan) 38073 Thalassiosira pseudonana (marine diatom) ENSTRUP00000002154 Takifugu rubripes (pufferfish Takifugu) 3755.m00440 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000054165 Xenopus tropicalis (frog) YALI0B14487g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12858 LH16233 ISCW005016 FBgn0068116 FBgn0217858 FBgn0207593 FBgn0196308 FBgn0170410 JGI_V11_299973 FBgn0078808 FBgn0148527 FBgn0141586 FBgn0127653 FBgn0112179 FBgn0089093 CPIJ015259 CPIJ003564 BGIBMGA009249 ACYPI004351 GB14059 AGAP001928 AAEL013951 AAEL012289 AAEL005567 PB20143 PHUM006700
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	35445 y1 sc* v1; P{TRiP.GL00370}attP2 13355 y1 w67c23; P{SUPor-P}Nap1KG03959 20031 w1118; P{EPgy2}Nap1EY08596/CyO, P{sevRas1.V12}FK1 8537 w1118; Dp(3;3)Nap1KO1, Nap1KO1.5' Nap1KO1.3'/T(2;3)SM6b-TM6B, apRK Tb1 8538 w1118; Dp(3;3)Nap1KO2, Nap1KO2.5' Nap1KO2.3'/T(2;3)SM6b-TM6B, apRK Tb1
Harvard	- PBac{PB}Nap1c05041 - PBac{WH}Nap1f06242
Kyoto	105173 y* w*; P{GawB}Nap1NP6266 / CyO, P{UAS-lacZ.UW14}UW14 113860 y* w*; P{GawB}Nap1NP6207 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v27392 w1118; P{GD11609}v27392 v27393 w1118; P{GD11609}v27393
Genomic Clones ( 1 )
	BACR05F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 265 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21576
Other clones	MIP15604
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05245 AT19437 GH08207 GH08253 GH08304 GH09485 GH15542 GH20939 GH23540 GM01190 GM01460 GM01683 GM02053 GM02139 GM03007 GM04167 GM05385 GM05808 GM09070 GM09656 GM10267 GM10865 GM19327 GM25695 GM26389 LD07642 LD24630 LD24732 LD26417 LD27442 LD38490 LD39925 LD41033 LP01557 LP02687 LP06323 LP11482 LP13130 LP13138 LP22682 RE08931 RE18577 RH03184 RH04880 RH05048 RH05115 RH05128 RH05138 RH05226 RH06278 RH06747 RH07563 RH07979 RH08017 RH08171 RH08245 RH08290 RH08392 RH08716 RH08893 RH10305 RH10732 RH11589 RH13779 RH14242 RH15463 RH16082 RH17443 RH18936 RH18995 RH19241 RH20117 RH21927 RH22924 RH23417 RH23767 RH24106 RH27836 RH29242 RH30287 RH30346 RH30760 RH32942 RH33031 RH33213 RH33445 RH35446 RH35957 RH36864 RH37069 RH38135 RH39163 RH43937 RH44493 RH45834 RH48513 RH52812 RH52938 RH55009 RH56315 RH58235 RH58626 RH58892 RH60485 RH60960 RH63309 RH63765 RH63989 RH64044 RH65144 RH67057 RH67627 RH68392 RH68686 RH69392 RH70088 RH70110 RH72011 RH72181 RH72304 RH72405 SD03766 SD08759 SD09336 SD09691 SD11041 SD12011 SD14949 SD14992 SD16347 SD18055 SD18136 SD18776 SD21160 SD22250 SD23293 SD23906 SD25288 SD26779 SD27480 SD28176
Other clones	15367 36648 38629 38925 76210 100722 102667 106205 162785 277073 524433 524447 558167 568899 575645 CK01.111B.D2 CK01.111B.E2 CK02690 Dmel_dig_000683_0649_3684 Dmel_dig_005045_0619_1660 Dmel_dig_011662_0657_0865 Dmel_dig_015333_0649_0719 Dmel_dig_015465_0700_3023 Dmel_dig_015834_0590_3559 Dmel_dig_019558_0678_3511 Dmel_neb_009320_0590_0863 Dmel_neb_009918_0112_2177 Dmel_neb_010298_0586_1937 Dmel_neb_010322_0636_1752 Dmel_neb_014362_0928_1153 Dmel_neb_014836_0903_0505 Dmel_neb_016525_0847_0773 EC31669 EC35130 EK131930 EK147236 EK151459 EK156112 EK174055 EK205521 EK223347 EK226025 EK233922 EK266514 EK304429 EN05363 EN05419 EN13126 EN14140 EN17460 ESG0118a.B21_C07 FGC003A05 FGC008B11 FGC031G11 FGM212E05 FGM221H11 FGM227F11 GH05424 GH27440 IP12883 IP13083 LD06387 LD16645 LD25650 LD38543 LD46663 LP06754 RE01905 RE40570 RH01855 RH03483 RH05966 RH05989 RH06822 RH06873 RH06880 RH06890 RH06965 RH08133 RH08150 RH09383 RH15224 RH20065 RH24272 RH24296 RH25481 RH34079 RH34501 RH35730 RH36431 RH37723 RH46648 RH48414 RH49795 RH51026 RH52202 RH52433 RH52611 RH73702 RP003016082 RP003030592 RP003051056 RP003082599 RP003119690 RP003161360 RP003242599 RP003248096 RP003255050 RP003258638 RP003340475 RP003363901 RP003399708 RP003417531 RP003434530 RP003437895 RP003491915 RP003583351 RP003633738 RP003673148 RP003675189 UUGC0929 UUGC1128
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015268 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37798
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nap1 CG5330 (Zhang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Acf1 together with a core histone chaperone (such as Caf1 or Nap1) is sufficient for ATP-dependent formation of periodic nucleosome arrays. (Ito et al., 1997) Nap1 acts as a core histone-binding protein (shuttle) which delivers histones from the cytoplasm to the chromatin assembly machinery in the nucleus. The p56 component of Caf4 (chromatin assembly factor 4). (Ito et al., 1996) Isolated as a protein that copurified with the p127 product of l(2)gl. (Neumann et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057780 RefSeq (Proteins) • NP_477128 DDBJ / EMBL / GenBank • AA735585 AAB07898 AAF47097 AAN71234 AC004347 AC005267 AI455168 BH615113 BT001479 CL610220 CZ469701 CZ484627 CZ484628 CZ488907 U39553 Entrez Gene - A searchable database of RefSeq genes. • 37798 UniProtKB/TrEMBL • Q9W1G7 Q24150
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nucleosome assembly protein (NAP) (IPR002164)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63390 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015268 DroID - A comprehensive database of gene and protein interactions. • FBgn0015268 DRSC - Results from RNAi screens. • FBgn0015268 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015268 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5330-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015268 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37798 InParanoid A subset of ortholog calls from InParanoid. • AAEL005567-PB Aedes aegypti (mosquito) AGAP009639-PA Anopheles gambiae (mosquito) XP_623275.1 Apis mellifera (honey bee) XP_001950710.1 Acyrthosiphon pisum (pea aphid) At4g26110.1 Arabidopsis thaliana (wall cress) 30577 Batrachochytrium dendrobatidis (chytrid fungus) 126640 Branchiostoma floridae (lancelet) 96619 Branchiostoma floridae (lancelet) XP_001897013.1 Brugia malayi (roundworm nematode) BGIBMGA009249-PA Bombyx mori (silk worm) ENSBTAP00000027852 Bos taurus (bovine) ENSBTAP00000038468 Bos taurus (bovine) CAL0006351 Candida albicans (a form of yeast) CBP20078 Caenorhabditis briggsae (nematode) CE04306 Caenorhabditis elegans (worm) ENSCAFP00000015053 Canis familiaris (dog) CAGL0M05973g Candida glabrata (haploid yeast) Chro.40090 Cryptosporidium hominis (obligate parasite) ENSCINP00000018743 Ciona intestinalis (sea squirt) JA15083 Caenorhabditis japonica (nematode) cn05450 Cryptococcus neoformans (yeast-like fungus) cgd4_720 Cryptosporidium parvum (protozoan parasite) CPIJ015259 Culex pipens (mosquito) ENSCPOP00000017660 Cavia porcellus (guinea pig) 192162 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000011356 Ciona savignyi (sedentary tunicate) 163453 Capitella spl (polychaete worm) DDB0267102 Dictyostelium discoideum (amoeba) DEHA2C11792g Debaryomyces Hansenii (yeast) 299973 Daphnia pulex (daphnia) ENSDARP00000027102 Danio rerio (zebra fish) ENSECAP00000000167 Equus caballus (horse) XP_651305 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014675 Gymnopilus aculeatus (mushroom) ENSGALP00000016623 Gallus gallus (chicken) 110599 Hypsipyla robusta (cedar shoot borer) ENSP00000261182 Homo sapiens (human) ISCW005016-PA Ixodes scapularis (deer tick) KLLA0E15049g Kluyveromyces lactis (yeast) 103941 Lottia gigantea (owl limpet) LmjF31.1750 Leishmania major (virus) ENSMODP00000025597 Monodelphis domestica (gray opossum) ENSMMUP00000026595 Macaca mulatta (rhesus monkey) ENSMMUP00000039127 Macaca mulatta (rhesus monkey) ENSMUSP00000070068 Mus musculus (house mouse) 236778 Nematostella vectensis (starlet anemone) XP_001607381.1 Nasonia vitripennis (wasp) ENSOANP00000007428 Ornithorynchus anatinus (platypus) ENSORLP00000015211 Oryzias latipes (japanese killifish) LOC_Os06g05660.1 Oryza sativa (asian rice) 4059 Ostreococcus tauri (green alga) PFL0185c Plasmodium falciparum (protozoal parasite) PHUM000389-PA Pediculus humanus (human body louse) PP12272 Pristionchus pacificus (nematode) 111058 Physcomitrella patens (moss) ENSPPYP00000005453 Pongo pygmaeus (orangutan) 74957 Phytophthora ramorum (sudden oak death pathogen) 134487 Phytophthora sojae (root rot pathogen) 819264 Populus trichocarpa (black cottonwood) ENSPTRP00000008901 Pan troglodytes (chimpanzee) PVX_084230 Plasmodium vivax (protozoal parasite) ENSRNOP00000005286 Rattus norvegicus (norway rat) 4896510 Sorghum bicolor (sorghum) YKR048C Saccharomyces cerevisiae (budding yeast) Smp_023530 Schistosoma mansoni (trematode parasite) SPCC364.06 Schizosaccharomyces pombe (fission yeast) XP_001196396.1 Strongylocentrotus purpuratus (purple sea urchin) 32481 Trichoplax adhaerens (metazoa) TA04600 Theileria annulata (apicomplexan parasite) Tc00.1047053507031.29 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008224 Tetraodon nigroviridis (green spotted pufferfish) TP03_0447 Theileria parva (parasitic protozoan) 38073 Thalassiosira pseudonana (marine diatom) ENSTRUP00000002154 Takifugu rubripes (pufferfish Takifugu) 3755.m00440 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000054165 Xenopus tropicalis (frog) YALI0B14487g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/nap-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37798 modMine - Data generated by the modENCODE project. • FBgn0015268 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12858 LH16233 ISCW005016 FBgn0068116 FBgn0217858 FBgn0207593 FBgn0196308 FBgn0170410 JGI_V11_299973 FBgn0078808 FBgn0148527 FBgn0141586 FBgn0127653 FBgn0112179 FBgn0089093 CPIJ015259 CPIJ003564 BGIBMGA009249 ACYPI004351 GB14059 AGAP001928 AAEL013951 AAEL012289 AAEL005567 PB20143 PHUM006700
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG5330 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dNap (Ismail et al., 2009) dNAP-1 (Bao et al., 2004, Levenstein and Kadonaga, 2002, Nakagawa et al., 2001, Huang and Kadonaga, 2001, Ito et al., 1999, Ito et al., 1997, Ito et al., 1996, Ito et al., 1996, Georges et al., 2002, Asahara et al., 2002, Sawatsubashi et al., 2010) dNAP1 (Jiang et al., 2000) dNap1 (Adams and Kamakaka, 1999) NAP1 (Polo, 2006, Verreault, 2000, Li et al., 1999, Li et al., 1999, Grunstein, 1997, Brasaemle and Hansen, 2006, Tanaka et al., 2007, Moshkin et al., 2009, Lusser et al., 2005) NAP-1 (Dilworth et al., 2004, Angelov et al., 2004, Fyodorov et al., 2004, Mondal et al., 2003, Alexiadis and Kadonaga, 2002, Loyola et al., 2001, Farkas et al., 2000, LeRoy et al., 2000, Ito, 1995.10.27, Baek, 1999, Ito et al., 1997, Livengood and Nyborg, 2004, Fyodorov and Kadonaga, 2002, Santoso and Kadonaga, 2006) Nap-1 (Lankenau et al., 2003, McNairn and Gilbert, 2003, Stephens et al., 2006) Nap1 (Blanco et al., 2010, Stuart et al., 2007, Lott et al., 2011, Hutter et al., 2008) p56/dCAF-4 (Ito et al., 1999)
Name Synonym	Nucleosome assembly protein 1
Secondary FlyBase IDs
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 3 ) Review  ( 10 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Sawatsubashi et al., 2010, Genes Dev. 24(2): 159--170 A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. [FBrf0209754] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...