neurofibromin, Neurofibromatosis-1, neurofibromatosis type 1, dNf1, NF-1
GAP-related domain protein functioning in the PKA pathway - critical to the biochemical processes underlying olfactory learning
Please see the JBrowse view of Dmel\Nf1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.47
9.750, 8.843 (compiled cDNA)
None of the polypeptides share 100% sequence identity.
2802, 2764 (aa); 280 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nf1 using the Feature Mapper tool.
Nf1 protein is expressed throughout the third instar larval and adult brain. In the adult, labelling is stronger in the mushroom body calyx and cortex (dendrites and cell bodies of Kenyon cells, respectively), protocerebral bridge, subesophageal ganglion and median bundle. Expression of Nf1 protein in the protocerebral bridge and mushroom body calyx colocalises with that of Alk protein.
Nf1 protein is expressed in all post-mitotic neurons in the larval central nervous system, at all larval stages.
Nf1 protein is widely expressed in low amounts.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Nf1 in GBrowse 23-89
3-89
3-87.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Nf1 mutant flies are defective in memory acquisition but not memory stability.
The reduced life span seen in Nf1 mutants is the product of the impairment of adenylyl cyclase/cAMP/PKA signalling.
Inactivation of Nf1 increases oxidative stress, mediated by downregulation of adenylyl cyclase/cAMP/PKA.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Nf1 has a role in circadian output via the Ras/MAPK signaling pathway.
Nf1 affects learning and short-term memory independently of its developmental effects.
Nf1 functions either upstream of adenylyl cyclase or in a parallel pathway.
Nf1 is a crucial component for activation of the cAMP pathway.