A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Mmus\Pkaca

General Information
SymbolMmus\PkacaSpeciesM. musculus
NamecAMP-dependent protein kinase α catalytic subunitAnnotation symbol
Feature typeengineered_foreign_geneFlyBase IDFBgn0015273
Gene Model StatusNot Applicable Stock availability None publicly available
Also Known AsPKA
Genomic Location
Chromosome (arm)Recombination map
Cytogenetic mapSequence location
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Automatically generated summary

See sections below for more information
The gene cAMP-dependent protein kinase α catalytic subunit is referred to in FlyBase by the symbol Mmus\Pkaca (FBgn0015273). It is a engineered_foreign_gene from Mus musculus. Its molecular function is unknown. The biological processes in which it is involved are not known. 8 alleles are reported. The phenotypes of these alleles are annotated with: aCC neuron; RP2 motor neuron; wing disc; photoreceptor cell; wing; nurse cell. It has no annotated transcripts. Gene has not been localized to the genome sequence.
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Description
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FB2013_03
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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
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Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
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External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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Reported size (kDa)
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Additional Descriptive Data
Marker for
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Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
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Lethality
Allele
lethal
lethal, with Scer\GAL4ap-md544
Other Phenotypes
Allele
behavior defective, with Scer\GAL430Y
behavior defective, with Scer\GAL4238Y
behavior defective, with Scer\GAL4c309
behavior defective, with Scer\GAL4Tab2-201Y
behavior defective | heat sensitive, with Scer\GAL4c309
behavior defective | RU486 conditional, with Scer\GAL4elav.Switch.PO
behavior defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch
developmental rate defective, with Scer\GAL4Itp-r83A-1664GAL4
increased cell death, with Scer\GAL4en-e16E
locomotor rhythm defective
mating behavior defective | female, with Scer\GAL4ppk.PG
neurophysiology defective, with Scer\GAL4eve.RN2
neurophysiology defective, with Scer\GAL4eve.RN2O
neurophysiology defective, with Scer\GAL4Mhc.PW
sleep defective, with Scer\GAL4104Y
temperature response defective | adult stage, with Scer\GAL4Mef2.247
visible, with Scer\GAL4en-e16E
visual behavior defective, with Scer\GAL4ninaE.PD
Phenotype manifest in
Allele
aCC neuron, with Scer\GAL4eve.RN2O
denticle belt | posterior, with Scer\GAL4e22c
nurse cell, with Scer\GAL4nos.PG
nurse cell, with Scer\GAL4nos.UTR.T:Hsim\VP16
photoreceptor cell, with Scer\GAL4ninaE.PD
RP2 motor neuron, with Scer\GAL4eve.RN2O
wing, with Scer\GAL4en-e16E
wing | pharate adult stage, with Scer\GAL4en-e16E
wing disc, with Scer\GAL471B
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Allele of Mmus\PkacaClassMutagenStocksKnown lesion
hide Alleles Carried on Transgenic Constructs ( 8 )
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Allele of Mmus\PkacaClassMutagenStocksKnown lesion
Mmus\PkacaAct5C.PJ0 Yes
Mmus\Pkacahs.PJ0 Yes
Mmus\PkacamC.Act5C0 Yes
Mmus\PkacamC.Scer\FRT.Act5C0 Yes
Mmus\PkacamC.Scer\FRT.Scer\UAS0 Yes
Mmus\PkacamC.Scer\UAS0 Yes
Mmus\PkacamC.Z.Act5C0 Yes
Mmus\PkacaScer\FRT.Act5C0 Yes
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Transgenic Constructs
Type of construct
Name
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Type of insertions
Name
Expression data
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engineered_foreign_gene
 
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Interacts with
Please look at the allele data for full details of the genetic interactions
Mmus\Pkaca allele
Gene
References
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hide OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
No orthologs identified
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
Ortholog(s) in Drosophila melanogaster (None identified)
No D. melanogaster orthologies identified
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Gene
OMIM
HGNC
hideAAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
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Clonal expression of Mmus\Pkaca demonstrates that hh does not induce dpp and wg transcription by down regulating cAMP-dependent Mmus\Pkaca activity, nor can constitutive Mmus\Pkaca activity compensate for loss of ptc gene function.
(Jiang and Struhl, 1995)
The mouse protein Mmus\Pkaca can function in Drosophila cells and is not readily inhibited by Pka-R1. Mmus\Pkaca can substitute for Pka-C1 function in imaginal discs.
(Li et al., 1995)
hide Tag or Foreign Gene Data
  • Foreign sequence; species == Mus musculus; gene == Pkaca; UniProt:P05132; MGI:97592.
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Sequence Crossreferences
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hide Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym
mC
(Jia et al., 2005)
Mmus\Pkaca
 
PKA
(Jia et al., 2002, Williams et al., 2001, Williams et al., 2001, Guo et al., 2000, Wang et al., 1999, Worden, 1998, Chyb et al., 1999, Price and Kalderon, 1999, Zhou et al., 2006, Smelkinson and Kalderon, 2006, Baines, 2004, Mee et al., 2004, Lee et al., 2009, Tong et al., 2007)
Pkaca
(Iijima-Ando et al., 2005)
PKAmc
(Yuan et al., 2011)
Name Synonym
cAMP-dependent protein kinase α catalytic subunit
 
PKA catalytic subunit
(Liu et al., 2007)
Secondary FlyBase IDs
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hide Recent research papers ( 4 )
Cheng et al., 2012, Development 139(1): 85--94
Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling. [FBrf0216860]
Liu et al., 2012, Curr. Biol. 22(22): 2114--2123
Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. [FBrf0220041]
Kang et al., 2011, PLoS ONE 6(12): e29800
Novel Cytochrome P450, cyp6a17, Is Required for Temperature Preference Behavior in Drosophila. [FBrf0217065]
Yuan et al., 2011, Science 333(6048): 1458--1462
Light-induced structural and functional plasticity in Drosophila larval visual system. [FBrf0215276]
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