FB2025_01 , released February 20, 2025
Gene: Mmus\Prkaca
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General Information
Symbol
Mmus\Prkaca
Species
M. musculus
Name
protein kinase, cAMP dependent, catalytic, alpha
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0015273
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

PKA

Key Links
Foreign Gene Data

Foreign sequence; species == Mus musculus; gene == Pkaca; UniProt:P05132; MGI:97592.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mmus\Prkaca
Transgenic constructs containing regulatory region of Mmus\Prkaca
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4ap-md544
lethal, with Scer\GAL4elav.PU
viable, with Scer\GAL4Act5C.PU
viable, with Scer\GAL4elav.PU
Other Phenotypes
Allele
abnormal behavior, with Scer\GAL430Y
abnormal behavior, with Scer\GAL4238Y
abnormal behavior, with Scer\GAL4c309
abnormal behavior, with Scer\GAL4Tab2-201Y
abnormal behavior | heat sensitive, with Scer\GAL4c309
abnormal behavior | RU486 conditional, with Scer\GAL4elav.Switch.PO
abnormal behavior | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal developmental rate, with Scer\GAL4Itpr-1664GAL4
abnormal locomotor rhythm
abnormal mating behavior | female, with Scer\GAL4ppk.PG
abnormal neuroanatomy, with Scer\GAL4G14
abnormal neurophysiology, with Scer\GAL4eve.RN2
abnormal neurophysiology, with Scer\GAL4eve.RN2O
abnormal neurophysiology, with Scer\GAL4Mhc.PW
abnormal sleep, with Scer\GAL4104Y
abnormal sleep |  :beta-estradiol conditional, with Ecol\lexAXVE.UAS, Scer\GAL4247
abnormal sleep | heat sensitive
abnormal sleep | RU486 conditional, with Ecol\lexALexPR.UAS, Scer\GAL4247
abnormal sleep | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal temperature response | adult stage, with Scer\GAL4Mef2.247
abnormal thermotaxis | RU486 conditional, with Scer\GAL4elav.Switch.PO
abnormal visual behavior, with Scer\GAL4ninaE.PD
abnormal wound healing | third instar larval stage, with Scer\GAL4tey-5053A
increased cell death, with Scer\GAL4en-e16E
increased cell growth rate | third instar larval stage | conditional, with Scer\GAL4tey-5053A
long lived
visible, with Scer\GAL4en-e16E
Phenotype manifest in
Allele
actin cytoskeleton, with Scer\GAL4moody.PS
apical plasma membrane | larval stage, with Scer\GAL4moody.PS
axon | third instar larval stage | conditional, with Scer\GAL4tey-5053A
embryonic/larval subperineurial glial cell | larval stage, with Scer\GAL4moody.PS
larval DA1 motor neuron, with Scer\GAL4eve.RN2O
larval RP2 motor neuron, with Scer\GAL4eve.RN2O
motor neuron | third instar larval stage | conditional, with Scer\GAL4tey-5053A
neuromuscular junction | third instar larval stage, with Scer\GAL4elav-C155
nurse cell, with Scer\GAL4nanos.PG
nurse cell, with Scer\GAL4VP16.nanos.UTR
perineurium | larval stage, with Scer\GAL4moody.PS
photoreceptor neuron, with Scer\GAL4ninaE.PD
septate junction | larval stage, with Scer\GAL4moody.PS
subperineurial glial cell, with Scer\GAL4moody.PS
terminal bouton, with Scer\GAL4G14
ventral denticle belt | posterior, with Scer\GAL4e22c
wing, with Scer\GAL4en-e16E
wing | pharate adult stage, with Scer\GAL4en-e16E
wing disc, with Scer\GAL471B
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Summary of Genetic Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Stocks (0)
    Other Comments

    Clonal expression of Mmus\Pkaca demonstrates that hh does not induce dpp and wg transcription by down regulating cAMP-dependent Mmus\Pkaca activity, nor can constitutive Mmus\Pkaca activity compensate for loss of ptc gene function.

    (Jiang and Struhl, 1995)

    The mouse protein Mmus\Pkaca can function in Drosophila cells and is not readily inhibited by Pka-R1. Mmus\Pkaca can substitute for Pka-C1 function in imaginal discs.

    (Li et al., 1995)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (11)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 1 )
    Other crossreferences
    Mouse Genome Database - The international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
    References (66)