Dp110, PI3K, p110, dPI3K, phosphoinositide 3-kinase
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
3.712 (compiled cDNA)
1088 (aa); 127 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pi3K92E using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pi3K92E in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Reduced postsynaptic Pi3K92E signaling results in reduced synapse size and increased quantal content without affecting quantal size.
High levels of Pi3K92E signaling promote tumour growth while low levels suppress tumour growth.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells.
Pi3K92E is autonomously required for imaginal disc cells to achieve their normal adult size, regulating cells size throughout the cell cycle. Pi3K92E normally promotes cell division and/or cell survival.
Identified by PCR using degenerate primers based on regions of strong amino acid homology found within the putative lipid kinase domain of mammalian p110α and yeast Vps34p.