FB2020_01, released Feb 12, 2020

Gene: Dmel\Pi3K92E

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General Information
Symbol
Dmel\Pi3K92E
Species
D. melanogaster
Name
Phosphatidylinositol 3-kinase 92E
Annotation Symbol
CG4141
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015279
Gene Model Status
Current
Stock Availability
26 publicly available
Enzyme Name (EC)
Phosphatidylinositol 3-kinase (2.7.1.137)
Phosphatidylinositol-4,5-bisphosphate 3-kinase (2.7.1.153)
Phosphatidylinositol-4-phosphate 3-kinase (2.7.1.154)
Gene Snapshot
Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As

Dp110, PI3K, p110, dPI3K, phosphoinositide 3-kinase

Key Links
Genomic Location
Cytogenetic map
92F3-92F3
Sequence location
3R:20,628,972..20,634,732 [-]
Recombination map

3-69

RefSeq locus
NT_033777 REGION:20628972..20634732
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; phosphatidylinositol 3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Predictions / Assertions
1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; phosphatidylinositol kinase activity
Catalytic Activity (EC)
Experimental Evidence
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate (2.7.1.137)
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (2.7.1.153)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate (2.7.1.154)
Predictions / Assertions
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate (2.7.1.137)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate (2.7.1.154)
Summaries
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Gene Group (FlyBase)
CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX -
Class IA phosphoinositide 3-kinase (PI3K) is a heterodimeric complex of a regulatory and catalytic subunit and is a core component of many many signaling pathways. In vitro, PI3Ks can phosphorylate phosphatidylinositol (PtdIns), PtdIns(4)P and PtdIns(4,5)P2 to generate PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively. (Adapted from PMID:24587488 and FBrf0227909).
PHOSPHATIDYLINOSITOL 3 KINASES -
Phosphatidylinositol 3 kinases catalyze the phosphorylation of phosphatidylinositol (PI), or specific mono or bisphosphate derivatives of PI, at position 3 on the inositol ring to generate PI3P, PI(3,4)P[[2]] or PI(3,4,5)P[[3]]. The resulting phosphoinositides can act as signalling molecules to mediate/regulate a range of cellular and physiological processes, including cell polarity, cell migration, autophagy, growth, development, and ageing. (Adapted from FBrf0227909.)
Summary (Interactive Fly)

an enzyme that synthesizes phosphatidylinositide lipids, which act as signals essential for growth - a target of the insulin pathway

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Pi3K92E or the JBrowse view of Dmel\Pi3K92E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pi3K92E-RA
FBtr0083940
NM_142645
4420
1088
Pi3K92E-RB
FBtr0083941
NM_169910
4347
1088
Pi3K92E-RC
FBtr0334643
NM_001275841
4839
1088
Additional Transcript Data and Comments
Reported size (kB)

3.712 (compiled cDNA)

(Leevers et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pi3K92E-PA
FBpp0083348
127.0
1088
7.62
NP_650902
AAF55792
Pi3K92E-PB
FBpp0083349
127.0
1088
7.62
NP_732536
AAN14359
Pi3K92E-PC
FBpp0306705
127.0
1088
7.62
NP_001262770
AGB96150
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1088 aa isoforms: Pi3K92E-PA, Pi3K92E-PB, Pi3K92E-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

1088 (aa); 127 (kD predicted)

(Leevers et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pi3K92E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (65 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
1-phosphatidylinositol-3-kinase activity
inferred from direct assay
(Orme et al., 2006, Leevers et al., 1996)
1-phosphatidylinositol-4-phosphate 3-kinase activity
inferred from direct assay
(Orme et al., 2006, Leevers et al., 1996)
phosphatidylinositol 3-kinase activity
inferred from direct assay
(Weinkove et al., 1997)
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
inferred from direct assay
(Orme et al., 2006, Leevers et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
1-phosphatidylinositol-3-kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
1-phosphatidylinositol-4-phosphate 3-kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (55 terms)
Terms Based on Experimental Evidence (52 terms)
CV Term
Evidence
References
autophagy
inferred from mutant phenotype
(Rusten et al., 2004)
carbohydrate homeostasis
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011)
cell competition in a multicellular organism
inferred from mutant phenotype
(Levayer et al., 2015)
cellular response to starvation
inferred from mutant phenotype
(Wu et al., 2009)
dendrite morphogenesis
inferred from direct assay
(Martin-Pena et al., 2006)
entry into diapause
inferred from mutant phenotype
(Williams et al., 2006)
female germ-line stem cell population maintenance
inferred from mutant phenotype
(Su et al., 2018)
glucose homeostasis
inferred from mutant phenotype
(Ugrankar et al., 2015)
hemocyte migration
inferred from mutant phenotype
(Wood et al., 2006)
instar larval development
inferred from mutant phenotype
(Caldwell et al., 2005)
insulin receptor signaling pathway
inferred from mutant phenotype
(Zhang et al., 2011, Miron et al., 2003, Britton et al., 2002, Radimerski et al., 2002, Clemens et al., 2000)
inferred from direct assay
(Lizcano et al., 2003, Scanga et al., 2000)
intestinal stem cell homeostasis
inferred from genetic interaction with FLYBASE:mir-305; FB:FBgn0262458
(Foronda et al., 2014)
larval development
inferred from mutant phenotype
(Mirth et al., 2005)
larval feeding behavior
inferred from mutant phenotype
(Wu et al., 2005)
larval salivary gland morphogenesis
inferred from mutant phenotype
(Takeo et al., 2005)
lipid homeostasis
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011, Britton et al., 2002)
lymph gland development
inferred from mutant phenotype
(Benmimoun et al., 2012)
metamorphosis
inferred from mutant phenotype
(Mirth et al., 2005)
multicellular organism growth
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011)
negative regulation of autophagy
inferred from mutant phenotype
(Wu et al., 2009)
negative regulation of feeding behavior
inferred from mutant phenotype
(Britton et al., 2002)
oogenesis
inferred from mutant phenotype
(Orme et al., 2006)
ovarian follicle cell development
inferred from mutant phenotype
(Jia et al., 2015)
phosphatidylinositol 3-kinase signaling
inferred from mutant phenotype
(assigned by UniProt )
(Oswald et al., 2018)
inferred from mutant phenotype
(Britton et al., 2002)
phosphatidylinositol phosphorylation
inferred from direct assay
(Weinkove et al., 1997, Leevers et al., 1996)
positive regulation of border follicle cell migration
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Sharma et al., 2018)
positive regulation of cell growth
inferred from mutant phenotype
(Roth et al., 2018)
inferred from genetic interaction with FLYBASE:Pi3K21B; FB:FBgn0020622, FLYBASE:Pten; FB:FBgn0026379
(Britton et al., 2002)
positive regulation of cell size
inferred from mutant phenotype
(Denton et al., 2012)
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
(Sims et al., 2009)
inferred from direct assay
(Parisi et al., 2011)
positive regulation of crystal cell differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
positive regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018, Orme et al., 2006, Leevers et al., 1996)
positive regulation of lamellocyte differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
positive regulation of lipid storage
inferred from mutant phenotype
(Cinnamon et al., 2016, Britton et al., 2002)
positive regulation of neuron remodeling
inferred from mutant phenotype
(Wong et al., 2013)
positive regulation of organ growth
inferred from mutant phenotype
(Scanga et al., 2000, Leevers et al., 1996)
positive regulation of plasmatocyte differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
positive regulation of protein kinase B signaling
inferred from mutant phenotype
(Clemens et al., 2000)
positive regulation of protein serine/threonine kinase activity
inferred from direct assay
(Scanga et al., 2000)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Dimitroff et al., 2012)
inferred from direct assay
(assigned by CACAO )
(Martin-Pena et al., 2006)
positive regulation of TORC1 signaling
inferred from mutant phenotype
(Kim et al., 2017)
positive regulation of translation
inferred from mutant phenotype
(Hall et al., 2007)
regulation of cell population proliferation
inferred from mutant phenotype
(Weinkove et al., 1999)
regulation of cell size
inferred from mutant phenotype
(Weinkove et al., 1999)
regulation of dendrite development
inferred from mutant phenotype
(Parrish et al., 2009)
regulation of long-term neuronal synaptic plasticity
inferred from direct assay
(Martin-Pena et al., 2006)
regulation of mitotic cell cycle
inferred from mutant phenotype
(Willecke et al., 2011)
regulation of multicellular organism growth
inferred from mutant phenotype
(Caldwell et al., 2005, Mirth et al., 2005)
regulation of reactive oxygen species metabolic process
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Lee et al., 2010)
regulation of synapse structural plasticity
inferred from mutant phenotype
(Mozer and Sandstrom, 2012)
regulation of synaptic plasticity
inferred from mutant phenotype
(assigned by UniProt )
(Oswald et al., 2018)
inferred from genetic interaction with UniProtKB:Q9VA37
(assigned by UniProt )
(Oswald et al., 2018)
response to oxidative stress
inferred from mutant phenotype
(Yang et al., 2005)
synapse maturation
inferred from direct assay
(Martin-Pena et al., 2006)
vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Read, 2018)
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
(Sims et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
cell migration
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol 3-kinase signaling
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol-3-phosphate biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol-mediated signaling
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
phosphatidylinositol 3-kinase complex, class IA
inferred from direct assay
(Weinkove et al., 1997)
inferred from physical interaction with FLYBASE:Pi3K21B; FB:FBgn0020622
(Leevers et al., 1996)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
(Gaudet et al., 2011)
membrane
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol 3-kinase complex
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
phosphatidylinositol 3-kinase complex, class IA
inferred from direct assay
(Weinkove et al., 1997)
inferred from physical interaction with FLYBASE:Pi3K21B; FB:FBgn0020622
(Leevers et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pi3K92E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pi3K92E
Transgenic constructs containing regulatory region of Pi3K92E
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PP
lethal | recessive
partially lethal - majority die, with Scer\GAL4en-e16E
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Adh.PF
viable, with Scer\GAL4en-e16E
viable, with Scer\GAL4repo.PU
viable, with Scer\GAL4tin.CΔ4
viable (with Pi3K92E2H1)
viable (with Pi3K92E5W3)
viable (with Pi3K92EA)
viable | RU486 conditional, with Scer\GAL4da.Switch.PT
Sterility
Allele
female sterile (with Pi3K92E6M5)
female sterile (with Pi3K92E6V2)
fertile, with Scer\GAL4Adh.PF
fertile, with Scer\GAL4en-e16E
Other Phenotypes
Allele
cell death defective | embryonic stage, with Scer\GAL4unspecified
cell growth defective, with Scer\GAL4P0206
cell growth defective | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
cell growth defective | somatic clone, with Scer\GAL4Act5C.PP
cell migration defective | larval stage, with Scer\GAL4repo
cell size defective, with Scer\GAL4amn-c651
cell size defective, with Scer\GAL4ccb-796
cell size defective, with Scer\GAL4phm.PO
chemical resistant, with Scer\GAL4elav-C155
chemical resistant | adult stage | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
chemical resistant | RU486 conditional, with Scer\GAL4da.Switch.PT
chemical sensitive, with Scer\GAL4elav-C155
decreased cell death, with Scer\GAL4hs.PB
decreased cell growth, with Scer\GAL4en.PU
decreased cell number, with Scer\GAL4dpp.blk1
decreased cell number, with Scer\GAL4GMR.PF
decreased cell number, with Scer\GAL4nub-AC-62
decreased cell number, with Scer\GAL4P0206
decreased cell size, with Scer\GAL4ap-md544
decreased cell size, with Scer\GAL4Bx-MS1096
decreased cell size, with Scer\GAL4dpp.blk1
decreased cell size, with Scer\GAL4GMR.PF
decreased cell size, with Scer\GAL4nub-AC-62
decreased cell size, with Scer\GAL4P0206
decreased cell size, with Scer\GAL4ppl.PP
decreased cell size | larval stage, with Scer\GAL4Desat1.PB
decreased cell size | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
decreased cell size | recessive | somatic clone
decreased fecundity | female | RU486 conditional, with Scer\GAL4da.Switch.PT
decreased occurrence of cell division | adult stage | RU486 conditional, with Scer\GAL4bun-GSG5961
decreased occurrence of cell division | larval stage, with Scer\GAL4nab
decreased occurrence of cell division | second instar larval stage, with Scer\GAL4repo.PU
developmental rate defective, with Scer\GAL4amn-c651
developmental rate defective, with Scer\GAL4P0206
developmental rate defective, with Scer\GAL4phm.PO
developmental rate defective | third instar larval stage, with Scer\GAL4amn-c651
developmental rate defective | third instar larval stage, with Scer\GAL4amn-X8
endomitotic cell cycle defective | larval stage | nutrition conditional, with Scer\GAL4Desat1.PB
feeding behavior defective, with Scer\GAL4Adh.PF
feeding behavior defective, with Scer\GAL4NPFR.6.6
hyperplasia, with Scer\GAL4GMR.PF
hyperplasia, with Scer\GAL4nub-AC-62
hyperplasia | larval stage, with Scer\GAL4repo
increased cell growth, with Scer\GAL4e22c
increased cell growth, with Scer\GAL4GMR.PF
increased cell number, with Scer\GAL4ccb-796
increased cell number, with Scer\GAL4dpp.blk1
increased cell number, with Scer\GAL4P0206
increased cell number | adult stage, with Scer\GAL4da.PU
increased cell number | adult stage, with Scer\GAL4dpp.blk1
increased cell size, with Scer\GAL4AB1
increased cell size, with Scer\GAL4Bx-MS1096
increased cell size, with Scer\GAL4dpp.blk1
increased cell size | adult stage, with Scer\GAL4dpp.blk1
increased cell size | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | larval stage, with Scer\GAL4Desat1.PB
increased cell size | larval stage | somatic clone | nutrition conditional, with Scer\GAL4FRT.Rnor\Cd2.Act5C
increased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | somatic clone, with Scer\GAL4αTub84B.PP
increased occurrence of cell division | larval stage, with Scer\GAL4nab
large body, with Scer\GAL4P0206
large body | adult stage, with Scer\GAL4amn-c651
large body | pupal stage, with Scer\GAL4amn-c651
large body | pupal stage, with Scer\GAL4amn-X8
locomotor behavior defective, with Scer\GAL4ccb-796
locomotor behavior defective | adult stage, with Scer\GAL4Mef2.PR
long lived | RU486 conditional, with Scer\GAL4bun-GSG5961
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
neuroanatomy defective, with Scer\GAL4C57
neuroanatomy defective, with Scer\GAL4ccb-796
neuroanatomy defective, with Scer\GAL4GH298
neuroanatomy defective, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
neuroanatomy defective, with Scer\GAL4GH298, Scer\GAL80ChAT.3.3P
neuroanatomy defective, with Scer\GAL4kra-krasavietz
neuroanatomy defective, with Scer\GAL4kra-krasavietz, Scer\GAL80Mef2.mb247
neuroanatomy defective, with Scer\GAL4Mef2.247
neuroanatomy defective, with Scer\GAL4ppk.PG
neuroanatomy defective, with Scer\GAL4smid-C161
neuroanatomy defective, with Scer\GAL4Toll-6-D42
neuroanatomy defective | adult stage, with Scer\GAL4pnr-MD237
neuroanatomy defective | larval stage, with Scer\GAL4ppk.PG
neuroanatomy defective | larval stage, with Scer\GAL4repo
neuroanatomy defective | pupal stage, with Scer\GAL4ppk.PG
neuroanatomy defective | somatic clone, with Scer\GAL4VGlut-OK371
neuroanatomy defective | third instar larval stage, with Scer\GAL4Gli-rL82
neurophysiology defective, with Scer\GAL4C57
neurophysiology defective, with Scer\GAL4elav.PLu
neurophysiology defective, with Scer\GAL4Toll-6-D42
neurophysiology defective | adult stage (with Pi3K92E2H1)
neurophysiology defective | adult stage (with Pi3K92E5W3)
neurophysiology defective | adult stage (with Pi3K92EA)
neurophysiology defective | adult stage | recessive
neurophysiology defective | third instar larval stage, with Scer\GAL4nSyb.PS
photoperiod response variant, with Scer\GAL4phm.PO
planar polarity defective | recessive | somatic clone
planar polarity defective | somatic clone, with Scer\GAL4Act5C.PP
short lived, with Scer\GAL4da.PU
short lived, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
size defective, with Scer\GAL4ap-md544
size defective, with Scer\GAL4Bx-MS1096
size defective, with Scer\GAL4en-e16E
size defective, with Scer\GAL4nub-AC-62
size defective | adult stage, with Scer\GAL4en-e16E
size defective | adult stage, with Scer\GAL4pnr-MD237
size defective | adult stage, with Scer\GAL4ptc.PU
size defective | cell autonomous, with Scer\GAL4dpp.blk1
size defective | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
size defective | cell non-autonomous, with Scer\GAL4dpp.blk1
size defective | third instar larval stage, with Scer\GAL4hh.PU
small body, with Scer\GAL4P0206
small body (with Pi3K92E2H1)
small body (with Pi3K92EA)
small body | adult stage (with Pi3K92E2H1)
small body | adult stage (with Pi3K92E5W3)
small body | adult stage (with Pi3K92EA)
small body | adult stage | recessive
small body | nutrition conditional, with Scer\GAL4ppl.PP
small body | pharate adult stage, with Scer\GAL4P0206
small body | pupal stage, with Scer\GAL4amn-c651
small body | second instar larval stage, with Scer\GAL4phm.PO
small body | somatic clone
small body | third instar larval stage, with Scer\GAL4phm.PO
smell perception defective, with Scer\GAL4GH298
smell perception defective, with Scer\GAL4GH298, Scer\GAL80ChAT.3.3P
smell perception defective, with Scer\GAL4kra-krasavietz
smell perception defective, with Scer\GAL4kra-krasavietz, Scer\GAL80Mef2.mb247
some die during larval stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4pnr-MD237
starvation stress response defective | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
starvation stress response defective | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
stress response defective, with Scer\GAL4en-e16E
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage (with Pi3K92E2H1)
visible | adult stage (with Pi3K92E5W3)
visible | adult stage | recessive
visible | embryonic stage, with Scer\GAL4unspecified
visible | somatic clone
wild-type
wound healing defective, with Scer\GAL4crq.PO
Phenotype manifest in
Allele
1st posterior cell, with Scer\GAL4dpp.blk1
1st posterior cell, with Scer\GAL4ptc-559.1
adult gut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
adult gut | RU486 conditional, with Scer\GAL4bun-GSG5961
adult mushroom body, with Scer\GAL4kra-krasavietz, Scer\GAL80ple.PK
adult mushroom body, with Scer\GAL4Tab2-201Y
antennal lobe, with Scer\GAL4GH298
antennal lobe, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
antennal lobe, with Scer\GAL4kra-krasavietz
antennal lobe glomerulus DM2, with Scer\GAL4GH298
antennal lobe glomerulus DM2, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
antennal lobe glomerulus DM2, with Scer\GAL4kra-krasavietz
autolysosome | third instar larval stage, with Scer\GAL4Act5C.PP
autophagosome, with Scer\GAL4Lsp2.PH
axon, with Scer\GAL4Toll-6-D42
Bolwig nerve, with Scer\GAL4repo
bouton, with Scer\GAL4C57
bouton, with Scer\GAL4Toll-6-D42
bouton | supernumerary, with Scer\GAL4ccb-796
cell body, with Scer\GAL4smid-C161
cell body | somatic clone, with Scer\GAL4VGlut-OK371
cell surface & nurse cell | somatic clone, with Scer\GAL4Act5C.PP
chaeta, with Scer\GAL4ap-md544
dendrite, with Scer\GAL4ccb-796
dendrite, with Scer\GAL4smid-C161
dendrite | larval stage, with Scer\GAL4ppk.PG
dendrite | somatic clone, with Scer\GAL4VGlut-OK371
egg chamber | germline clone
ellipsoid body, with Scer\GAL4ccb-796
embryo | dorsal closure stage
embryo | dorsal closure stage, with Scer\GAL4en.PU
embryonic/first instar larval cuticle, with Scer\GAL4unspecified
embryonic/larval digestive system | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval epidermis | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval fat body | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval fat body | larval stage | somatic clone | nutrition conditional, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval fat body | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PU
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval glial cell, with Scer\GAL4repo
embryonic/larval gut | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval Malpighian tubule | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval neuromuscular junction, with Scer\GAL4elav.PLu
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4nSyb.PS
embryonic/larval oenocyte | larval stage, with Scer\GAL4Desat1.PB
embryonic/larval oenocyte | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval optic stalk, with Scer\GAL4repo
embryonic/larval peripheral nervous system | third instar larval stage, with Scer\GAL4Gli-rL82
embryonic/larval salivary gland, with Scer\GAL429BD
embryonic/larval salivary gland, with Scer\GAL4AB1
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic/larval salivary gland, with Scer\GAL4hs.PB
embryonic/larval salivary gland, with Scer\GAL4nub-AC-62
embryonic/larval salivary gland, with Scer\GAL4ppl.PP
embryonic leading edge cell
embryonic leading edge cell, with Scer\GAL4en.PU
eye, with Scer\GAL4Bx-MS1096
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4P0206
eye disc | larval stage, with Scer\GAL4repo
eye disc | somatic clone, with Scer\GAL4Act5C.PP
fat body
fat body, with Scer\GAL4Act5C.PP
fat body | somatic clone, with Scer\GAL4αTub84B.PP
fat cell | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
gastric caecum | somatic clone, with Scer\GAL4Act5C.PP
germ band, with Scer\GAL4Kr.PM
head capsule | somatic clone
imaginal disc
imaginal disc & cell, with Scer\GAL4Act5C.PP
interommatidial bristle, with Scer\GAL4GMR.PF
intestinal stem cell | adult stage, with Scer\GAL4NP0677
intrinsic neuron, with Scer\GAL4GH298
intrinsic neuron, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
intrinsic neuron, with Scer\GAL4kra-krasavietz
intrinsic neuron, with Scer\GAL4Mef2.247
larva
larval dorsal multidendritic neuron ddaC, with Scer\GAL4smid-C161
larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG
larval multidendritic class IV neuron, with Scer\GAL4ppk.PG
larval neuroblast, with Scer\GAL4nab
larval neuroblast, with Scer\GAL4repo.PU
lysosome, with Scer\GAL4Lsp2.PH
mechanosensory neuron of posterior dorsocentral bristle, with Scer\GAL4pnr-MD237
mesothoracic tergum, with Scer\GAL4ap-md544
mesothoracic tergum, with Scer\GAL4pnr-MD237
mesothoracic tergum | pupal stage | somatic clone, with Scer\GAL4FRT.Act5C
mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
motor neuron, with Scer\GAL4Toll-6-D42
motor neuron | somatic clone, with Scer\GAL4VGlut-OK371
neuroblast | third instar larval stage | nutrition conditional, with Scer\GAL4insc-Mz1407
neuron | supernumerary, with Scer\GAL4ccb-796
neuron projection | adult stage, with Scer\GAL4pnr-MD237
neuropil | somatic clone, with Scer\GAL4VGlut-OK371
nucleus | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
ommatidial precursor cluster | somatic clone, with Scer\GAL4Act5C.PP
ommatidium, with Scer\GAL4GMR.PF
ommatidium | somatic clone
ovary (with Pi3K92E6M5)
ovary (with Pi3K92E6V2)
plasmatocyte | ectopic, with Scer\GAL4Gli-rL82
prothoracic gland, with Scer\GAL4amn-c651
prothoracic gland, with Scer\GAL4P0206
prothoracic gland, with Scer\GAL4phm.PO
puparium cuticle, with Scer\GAL4phm.PO
ring canal, with Scer\GAL4P0206
synapse
synapse, with Scer\GAL4C57
synapse, with Scer\GAL4GH298
synapse, with Scer\GAL4GH298, Scer\GAL4kra-krasavietz
synapse, with Scer\GAL4kra-krasavietz
synapse, with Scer\GAL4Mef2.247
synapse, with Scer\GAL4Toll-6-D42
synapse | adult stage, with Scer\GAL4pnr-MD237
synapse | supernumerary, with Scer\GAL4ccb-796
synapse | supernumerary, with Scer\GAL4Toll-6-D42
wing
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4e22c
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4P0206
wing, with Scer\GAL4αTub84B.PC
wing (with Pi3K92E2H1)
wing (with Pi3K92E5W3)
wing & cell, with Scer\GAL4dpp.blk1
wing | posterior, with Scer\GAL4en-e16E
wing blade, with Scer\GAL4ap-md544
wing blade, with Scer\GAL4ptc.PU
wing disc, with Scer\GAL429BD
wing disc | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PU
wing disc posterior compartment, with Scer\GAL4en-e16E
wing disc posterior compartment | third instar larval stage, with Scer\GAL4hh.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PIK3CD
14 of 15
Yes
Yes
 
Hsap\PIK3CB
11 of 15
No
Yes
 
Hsap\PIK3CA
6 of 15
No
Yes
Hsap\PIK3CG
3 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Pik3cd
14 of 15
Yes
Yes
Mmus\Pik3cb
11 of 15
No
Yes
Mmus\Pik3ca
6 of 15
No
Yes
Mmus\Pik3cg
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
Rnor\Pik3cb
11 of 13
Yes
Yes
Rnor\Pik3cd
10 of 13
No
Yes
Rnor\LOC100910021
3 of 13
No
Yes
Rnor\Pik3ca
2 of 13
No
Yes
Rnor\LOC685590
1 of 13
No
Yes
Rnor\Pik3cg
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\pik3cb
6 of 12
Yes
Yes
Xtro\pik3ca
2 of 12
No
Yes
Xtro\pik3cg
2 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\pik3cb
11 of 15
Yes
Yes
Drer\pik3cd
9 of 15
No
Yes
Drer\pik3ca
6 of 15
No
Yes
Drer\zgc:158659
4 of 15
No
Yes
Drer\si:rp71-17i16.5
3 of 15
No
Yes
Drer\pik3cg
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\age-1
10 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\VPS34
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190179 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Pi3K92E
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012669
Drosophila simulans
Dsim\GD20048
Drosophila sechellia
Dsec\GM23175
Drosophila erecta
Dere\GG15290
Drosophila yakuba
Dyak\GE25053
Drosophila ananassae
Dana\GF18327
Drosophila pseudoobscura pseudoobscura
Dpse\GA17984
Drosophila persimilis
Dper\GL27142
Drosophila willistoni
Dwil\GK22711
Drosophila virilis
Dvir\GJ24290
Drosophila mojavensis
Dmoj\GI22170
Drosophila grimshawi
Dgri\GH16124
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500SW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020324
Glossina morsitans
Tsetse fly
Gmor\GMOY007628
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05279
Mayetiola destructor
Hessian fly
Mdes\Mdes008654
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002903
Anopheles darlingi
American malaria mosquito
Adar\ADAC007181
Anopheles gambiae
Malaria mosquito
Agam\AGAP000018
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005543
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01HB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002921
Danaus plexippus
Monarch butterfly
Dple\DPOGS200172-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007559
Heliconius melpomene
Postman butterfly
Hmel\HMEL002237
Apis florea
Little honeybee
Aflo\2297565956
Apis mellifera
Western honey bee
Amel\LOC551500
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22821
Bombus terrestris
Buff-tailed bumblebee
Bter\15210523
Linepithema humile
Argentine ant
Lhum\LH24494
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000104
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016627
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07326
Tribolium castaneum
Red flour beetle
Tcas\TC011996
Pediculus humanus
Human body louse
Phum\PHUM169940
Rhodnius prolixus
Kissing bug
Rpro\RPRC009293
Cimex lectularius
Bed bug
Clec\CLEC012922
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001335
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01400
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01FG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004020
Ixodes scapularis
Black-legged tick
Isca\ISCW010469
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69077.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g00420
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_117886
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G027R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pi3kp110b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pi3kp110_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pi3kp110
Ciona intestinalis
Vase tunicate
Cint\LOC100180112
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005192
Gallus gallus
Domestic chicken
Ggal\PIK3CA
Gallus gallus
Domestic chicken
Ggal\PIK3CB
Gallus gallus
Domestic chicken
Ggal\PIK3CG
Gallus gallus
Domestic chicken
Ggal\PIK3CD
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Pi3K59F
2 of 10
Pi3K68D
2 of 10
fwd
1 of 10
Pi4KIIIα
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 9 )
Modifiers Based on Experimental Evidence ( 5 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
14 of 15
602839
     
    PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
    11 of 15
    602925
         
        PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
        6 of 15
        171834
        PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
        3 of 15
        601232
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Pi3K92E
            protein kinase assay, autoradiography
            (Weinkove et al., 1997)
            Pi3K92E - Act5C
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - CG15784
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - CG30122
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Droj2
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Fib
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Git
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Glatter et al., 2011)
            Pi3K92E - Hsc70-3
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - InR
            anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting
            (Vinayagam et al., 2016, Friedman et al., 2011)
            Pi3K92E - Iswi
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Mec2
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Nsun2
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Pi3K21B
            anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, anti tag western blot, Identification by mass spectrometry, western blot, protein kinase assay, autoradiography, anti bait coimmunoprecipitation
            (Breitkopf et al., 2016, Vinayagam et al., 2016, Glatter et al., 2011, Orme et al., 2006, Wittwer et al., 2005, Weinkove et al., 1997)
            Pi3K92E - Psi
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Pvr
            anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry
            (Breitkopf et al., 2016, Vinayagam et al., 2016)
            Pi3K92E - PyK
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Ranbp9
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Ras85D
            pull down, western blot, two hybrid
            (Orme et al., 2006)
            Pi3K92E - Rm62
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL10
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL13A
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL14
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL17
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL18
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL19
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL21
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL28
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL35A
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL6
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL7A
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL8
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpL9
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpLP1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS11
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS15
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS15Aa
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS17
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS23
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS26
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS6
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS7
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RpS9
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Rpt4
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - RtGEF
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Glatter et al., 2011)
            Pi3K92E - Syp
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - Zn72D
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - alt
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - chico
            anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting
            (Breitkopf et al., 2016, Vinayagam et al., 2016)
            Pi3K92E - eIF3a
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - eIF3b
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - eIF3c
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - eIF3m
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - eIF4A
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - iPLA2-VIA
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - larp
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - msn
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - ncd
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - nonA
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - rin
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - rump
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - sta
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - vig
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - vig2
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Pi3K92E - yps
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Pi3K92E
            suppressible
            Akt1
            (Radimerski et al., 2002, Scanga et al., 2000)
            Pi3K92E|foxo
            suppressible
            Akt1
            (Goberdhan et al., 2005)
            Pi3K92E
            enhanceable
            Akt1
            (Radimerski et al., 2002)
            Pi3K92E|btl::Egfr
            suppressible
            Akt1
            (Read et al., 2009)
            Pi3K92E
            suppressible
            ap
            (Coelho et al., 2005)
            Pi3K92E
            suppressible
            aru
            (Eddison et al., 2011)
            Pi3K92E
            enhanceable
            btl::Egfr
            (Witte et al., 2009)
            Pi3K92E
            suppressible
            btl::Egfr
            (Witte et al., 2009)
            Pi3K92E|btl::Egfr
            suppressible
            Cdk4
            (Read et al., 2009)
            Pi3K92E
            suppressible
            Cds
            (Liu et al., 2014)
            Pi3K92E
            enhanceable
            chico
            (Coelho et al., 2005)
            Pi3K92E
            suppressible
            Chro
            (Li et al., 2017)
            Pi3K92E|btl::Egfr
            suppressible
            dap
            (Read et al., 2009)
            Pi3K92E
            enhanceable
            Dronc
            (Berry and Baehrecke, 2007)
            Pi3K92E
            enhanceable
            E-2c
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            E-2fa
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            E-2fb
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            E-3c1
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            E-3c4
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            E-3c7
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            ebi
            (Marygold et al., 2011, Coelho et al., 2005)
            Pi3K92E|btl::Egfr
            suppressible
            eIF4E1
            (Read et al., 2009)
            Pi3K92E
            suppressible
            FarO
            (Cinnamon et al., 2016)
            Pi3K92E|btl::Egfr
            suppressible
            foxo
            (Read et al., 2009)
            Pi3K92E
            suppressible
            foxo
            (Slack et al., 2011, Colombani et al., 2005, Junger et al., 2003)
            Pi3K92E
            suppressible
            HDAC3
            (Lv et al., 2012)
            Pi3K92E
            enhanceable
            His4
            (Lv et al., 2012)
            Pi3K92E
            enhanceable
            hppy
            (Resnik-Docampo and de Celis, 2011)
            Pi3K92E
            enhanceable
            InR
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            lep
            (Coelho et al., 2005)
            Pi3K92E
            suppressible
            lilli
            (Tang et al., 2001)
            Pi3K92E|btl::Egfr
            suppressible
            Max
            (Read et al., 2009)
            Pi3K92E|btl::Egfr
            suppressible
            Myc
            (Read et al., 2009)
            Pi3K92E
            enhanceable
            ncm
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            Pdk1
            (Cho et al., 2001)
            Pi3K92E
            suppressible
            Pdk1
            (Cho et al., 2001)
            Pi3K92E
            enhanceable
            pix
            (Coelho et al., 2005, Coelho et al., 2005)
            Pi3K92E|btl::Egfr
            suppressible
            pnt
            (Read et al., 2009)
            Pi3K92E
            enhanceable
            Prp8
            (Coelho et al., 2005)
            Pi3K92E
            suppressible
            Pten
            (Goberdhan et al., 1999)
            Pi3K92E|btl::Egfr
            suppressible
            Pten
            (Read et al., 2009)
            Arf79F|Pi3K92E
            suppressible
            Pten
            (Khadilkar et al., 2014)
            Pi3K92E
            enhanceable
            Pten
            (Gao et al., 2000)
            Pi3K92E
            enhanceable
            Ptp61F
            (Tchankouo-Nguetcheu et al., 2014)
            Pi3K92E|btl::Egfr
            suppressible
            raptor
            (Read et al., 2009)
            Pi3K92E|btl::Egfr
            suppressible
            Ras85D
            (Read et al., 2009)
            btl::Egfr|Pi3K92E
            enhanceable
            Rbf
            (Read et al., 2009)
            Pi3K92E|btl::Egfr
            suppressible
            Rbf
            (Read et al., 2009)
            Pi3K92E
            suppressible
            Rheb
            (Saucedo et al., 2003)
            Pi3K92E
            suppressible
            rictor
            (Hietakangas and Cohen, 2007)
            Pi3K92E|btl::Egfr
            suppressible
            RIOK1
            (Read et al., 2013)
            Pi3K92E
            suppressible
            RIOK1
            (Read et al., 2013)
            Pi3K92E|btl::Egfr
            suppressible
            RIOK2
            (Read et al., 2013)
            Pi3K92E
            suppressible
            RIOK2
            (Read et al., 2013)
            Pi3K92E
            enhanceable
            RpL5
            (Coelho et al., 2005)
            Pi3K92E
            suppressible
            RpL8
            (Xu et al., 2008)
            Pi3K92E
            enhanceable
            RpL38
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpLP1
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS3
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS3A
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS5a
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS13
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS17
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS21
            (Coelho et al., 2005)
            Pi3K92E
            enhanceable
            RpS26
            (Coelho et al., 2005)
            Pi3K92E|btl::Egfr
            suppressible
            S6k
            (Read et al., 2009)
            Pi3K92E
            enhanceable
            Sesn
            (Lee et al., 2010)
            Pi3K92E
            suppressible
            Sesn
            (Lee et al., 2010)
            Pi3K92E|btl::Egfr
            suppressible
            Sin1
            (Read et al., 2009)
            Pi3K92E
            suppressible
            srl
            (Tiefenböck et al., 2010)
            Pi3K92E|btl::Egfr
            suppressible
            stg
            (Read et al., 2009)
            btl::Egfr|Pi3K92E
            enhanceable
            stg
            (Read et al., 2009)
            Pi3K92E|btl::Egfr
            suppressible
            Thor
            (Read et al., 2009)
            Pi3K92E
            suppressible
            Tl
            (Roth et al., 2018)
            Pi3K92E
            enhanceable
            Tor
            (Coelho et al., 2005)
            Pi3K92E|btl::Egfr
            suppressible
            Tor
            (Read et al., 2009)
            Pi3K92E
            suppressible
            Tor
            (Berry and Baehrecke, 2007)
            Pi3K92E
            suppressible
            Trpm
            (Georgiev et al., 2010)
            btl::Egfr|Pi3K92E
            enhanceable
            Tsc1
            (Read et al., 2009)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Arf79F
            suppressible
            Pi3K92E
            (Khadilkar et al., 2014)
            Atg9
            suppressible
            Pi3K92E
            (Wen et al., 2017)
            btl::Egfr
            enhanceable
            Pi3K92E
            (Witte et al., 2009)
            btl::Egfr
            suppressible
            Pi3K92E
            (Witte et al., 2009)
            CaMKII
            suppressible
            Pi3K92E
            (Chun-Jen Lin et al., 2011)
            Cds
            suppressible
            Pi3K92E
            (Liu et al., 2014)
            chico
            enhanceable
            Pi3K92E
            (Bohni et al., 1999)
            Cul1
            suppressible
            Pi3K92E
            (Wong et al., 2013)
            CycE
            suppressible
            Pi3K92E
            (Lin et al., 2011)
            Dcp-1
            enhanceable
            Pi3K92E
            (Kim et al., 2010)
            DJ-1α
            enhanceable
            Pi3K92E
            (Yang et al., 2005)
            DJ-1α
            suppressible
            Pi3K92E
            (Yang et al., 2005)
            Dl|ct
            suppressible
            Pi3K92E
            (Zhai et al., 2012)
            egh
            suppressible
            Pi3K92E
            (Dahlgaard et al., 2012)
            foxo
            enhanceable
            Pi3K92E
            (Goberdhan et al., 2005, Junger et al., 2003, Kramer et al., 2003)
            foxo
            suppressible
            Pi3K92E
            (Kramer et al., 2003)
            hppy
            enhanceable
            Pi3K92E
            (Resnik-Docampo and de Celis, 2011)
            Itpr
            suppressible
            Pi3K92E
            (Subramanian et al., 2013)
            Mical
            enhanceable
            Pi3K92E
            (Wong et al., 2013)
            mir-278
            suppressible
            Pi3K92E
            (Teleman and Cohen, 2006)
            mir-305
            suppressible
            Pi3K92E
            (Foronda et al., 2014)
            mir-ban
            suppressible
            Pi3K92E
            (Raisin et al., 2003)
            p53
            enhanceable
            Pi3K92E
            (Lee et al., 2003)
            Pi3K21B
            suppressible
            Pi3K92E
            (Ejeskär et al., 2015)
            Pten
            suppressible
            Pi3K92E
            (Gao et al., 2000, Goberdhan et al., 1999, Huang et al., 1999)
            Pten
            enhanceable
            Pi3K92E
            (Gao et al., 2000, Huang et al., 1999)
            Pvr
            suppressible
            Pi3K92E
            (Bruckner et al., 2004)
            Ras85D
            suppressible
            Pi3K92E
            (Willecke et al., 2011)
            Ras85D|dlg1
            suppressible
            Pi3K92E
            (Katheder et al., 2017, Willecke et al., 2011)
            sl
            enhanceable
            Pi3K92E
            (Murillo-Maldonado et al., 2011)
            sl
            suppressible
            Pi3K92E
            (Murillo-Maldonado et al., 2011)
            spidey
            suppressible
            Pi3K92E
            (Cinnamon et al., 2016)
            Tor
            enhanceable
            Pi3K92E
            (Hennig and Neufeld, 2002)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Insulin-like Receptor Signaling Pathway Core Components -
            The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
            Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
            PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
            Metabolic Pathways
            External Data
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-69

            Cytogenetic map
            92F3-92F3
            Sequence location
            3R:20,628,972..20,634,732 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            92F3-92F3
            Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            92E12-92E13
            (Leevers, 1996.10.25)
            92E12-92E13
            (determined by in situ hybridisation)
            (Leevers, 1996.12.5, Leevers et al., 1996)
            92D-92D
            (determined by in situ hybridisation)
            (MacDougall et al., 1995)
            92D1-92D4
            (determined by in situ hybridisation)
            (MacDougall and Leevers, 1995.10.6)
            92E-92E
            (Maier et al., 1992)
            Experimentally Determined Recombination Data
            Location

            3-69

            (FlyBase, 2016)

            3-72.8

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (26)
            Genomic Clones (21)
            cDNA Clones (112)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Leevers et al., 1996)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Pi3K92E CG4141

              (Gong, 1999.11)
              Source for database merge of

              Source for merge of: Pi3K92E anon-92Ed

              (Weinkove et al., 1999)
              Additional comments
              Other Comments

              Reduced postsynaptic Pi3K92E signaling results in reduced synapse size and increased quantal content without affecting quantal size.

              (Mozer and Sandstrom, 2012)

              The activation of Pi3K92E by mGluRA is mediated by CaMKII and Fak56D.

              (Chun-Jen Lin et al., 2011)

              High levels of Pi3K92E signaling promote tumour growth while low levels suppress tumour growth.

              (Willecke et al., 2011)

              Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body.

              (Scott et al., 2004)

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells.

              (Kiger et al., 2003)

              Pi3K92E is autonomously required for imaginal disc cells to achieve their normal adult size, regulating cells size throughout the cell cycle. Pi3K92E normally promotes cell division and/or cell survival.

              (Weinkove et al., 1999)

              The Pi3K92E/Pi3K21B complex possesses lipid kinase activity.

              (Leevers et al., 1996)

              Molecular and functional analysis of Pi3K92E implies a role for Pi3K92E in growth control during development.

              (Leevers et al., 1996)

              Identified by PCR using degenerate primers based on regions of strong amino acid homology found within the putative lipid kinase domain of mammalian p110α and yeast Vps34p.

              (MacDougall et al., 1995)

              Maps within 10kb of the H gene.

              (Maier et al., 1992)

              Identified as a transcription unit during molecular analysis of H.

              (Maier et al., 1992)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 79 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (60)
              Reported As
              Symbol Synonym
              CG4141
              (Dey et al., 2017, Balakrishnan et al., 2015, Hosono et al., 2015, Schertel et al., 2013, Bridon et al., 2012, Glatter et al., 2011, Ni et al., 2011.7.19, Sun et al., 2010, Abe et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Qin et al., 2008, Morrison et al., 2000)
              DP110
              (Jouette et al., 2017, Monyak et al., 2017, Willecke et al., 2011)
              Dmp110
              (Leevers et al., 1995)
              Dp110
              (Hansen et al., 2019, Wang et al., 2019, Alpar et al., 2018, Poon et al., 2018, Roth et al., 2018, Das and Arur, 2017, Jordán-Álvarez et al., 2017, Liao et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Romero-Pozuelo et al., 2017, Xiang et al., 2017, Yun et al., 2017, Zheng et al., 2017, Cinnamon et al., 2016, Kučerová et al., 2016, Ejeskär et al., 2015, Panneton et al., 2015, Schmitt et al., 2015, Avet-Rochex et al., 2014, Banreti et al., 2014, Liu et al., 2014, Radermacher et al., 2014, Hahn et al., 2013, Levayer and Moreno, 2013, Shim et al., 2013, Sim and Denlinger, 2013, Subramanian et al., 2013, Avet-Rochex et al., 2012, Dahlgaard et al., 2012, Denton et al., 2012, Pallares-Cartes et al., 2012, Karpac et al., 2011, Lin et al., 2011, Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011, Partridge et al., 2011, Resnik-Docampo and de Celis, 2011, Slack et al., 2011, Zhang et al., 2011, Biteau et al., 2010, McLeod et al., 2010, Siegrist et al., 2010, Slack et al., 2010, Tiefenböck et al., 2010, Diangelo et al., 2009, Jiang and Edgar, 2009, Jones et al., 2009, Kent et al., 2009, Mirth et al., 2009, Werz et al., 2009, Wu et al., 2009, Jones and Grotewiel, 2008, Learte et al., 2008, Leevers, 2008.10.20, McNeill et al., 2008, Xu et al., 2008, Berry and Baehrecke, 2007, Hall et al., 2007, Hietakangas and Cohen, 2007, Senoo-Matsuda and . Johnston, 2007, Wells and Johnston, 2007, Anonymous, 2006, Betschinger et al., 2006, DiAngelo and Birnbaum, 2006, Fuss et al., 2006, Herranz et al., 2006, Liu and Lehmann, 2006, Orme et al., 2006, Patel and Tamanoi, 2006, Vereshchagina and Wilson, 2006, Walker et al., 2006, Williams et al., 2006, Wood et al., 2006, Coelho et al., 2005, Goberdhan et al., 2005, Lievens et al., 2005, Mikeladze-Dvali et al., 2005, Mirth et al., 2005, Mirth et al., 2005, Orme and Leevers, 2005, Partridge et al., 2005, Sustar and Schubiger, 2005, Teleman et al., 2005, Wu et al., 2005, Bateman and McNeill, 2004, MacDougall et al., 2004, Papadopoulou et al., 2004, Reiling and Hafen, 2004, Resino and Garcia-Bellido, 2004, Rusten et al., 2004, de la Cova and Johnston, 2003, Junger et al., 2003, Miron et al., 2003, Raisin et al., 2003, Saucedo et al., 2003, Williams et al., 2003, Yang and Baker, 2003, Aigaki et al., 2002, Britton et al., 2002, Claeys et al., 2002, Hennig and Neufeld, 2002, Hipfner et al., 2002, Prober and Edgar, 2002, Radimerski et al., 2002, Towers and Sattelle, 2002, Xue and Noll, 2002, Cho et al., 2001, Clancy et al., 2001, Coelho et al., 2001, Gems and Partridge, 2001, Halfar et al., 2001, Miron et al., 2001, Radimerski et al., 2001, Rintelen et al., 2001, Strauss, 2001, Tang et al., 2001, Britton and Edgar, 2000, Coelho and Leevers, 2000, Raabe, 2000, Scanga et al., 2000, Teleman and Cohen, 2000, Weinkove and Leevers, 2000, Bohni et al., 1999, Coelho and Leevers, 1999, Goberdhan et al., 1999, Leevers, 1999, Leevers et al., 1999, Moghal and Sternberg, 1999, Weinkove et al., 1999, Leevers et al., 1998, Riesgo-Escovar et al., 1998, Rommel and Hafen, 1998, Wymann and Pirola, 1998, Leevers et al., 1997, Vanhaesebroeck et al., 1997, Weinkove et al., 1997, Weinkove et al., 1997, Leevers, 1996.12.5, Leevers et al., 1996)
              Dp110/PI3K
              (Stocker et al., 2004)
              Dpp110
              (Walker et al., 2011)
              PI(3)K
              (Fuss et al., 2007, Orme et al., 2006, Rintelen et al., 2001, Edgar, 1999, Lehner, 1999)
              PI-3 kinase
              (Read and Thomas, 2008)
              PI-3-K
              (Davies, 2002)
              PI3'K
              (Scanga et al., 2000)
              PI3K
              (Borreguero-Muñoz et al., 2019, Boulan et al., 2019, Hansen et al., 2019, Kim and Choi, 2019, Portela et al., 2019, Su et al., 2019, Toshniwal et al., 2019, Lee et al., 2018, Arnés et al., 2017, Gupta and Ray, 2017, Kim et al., 2017, Li et al., 2017, Wen et al., 2017, Yun et al., 2017, Zheng et al., 2017, Jia et al., 2015, Okamoto and Nishimura, 2015, Ugrankar et al., 2015, Homem et al., 2014, Khadilkar et al., 2014, Radermacher et al., 2014, Ibar et al., 2013, Luo et al., 2013, Nässel et al., 2013, Nirala et al., 2013, Pickering et al., 2013, Subramanian et al., 2013, Tixier et al., 2013, Wong et al., 2013, Acebes et al., 2012, Choi and Hyun, 2012, Jordán-Álvarez et al., 2012, Lv et al., 2012, Morris et al., 2012, Mozer and Sandstrom, 2012, Murray et al., 2012, Chun-Jen Lin et al., 2011, Kamakura, 2011, Zhang et al., 2011, Aron et al., 2010, Chell and Brand, 2010, Delanoue et al., 2010, Georgiev et al., 2010, Kockel et al., 2010, Kremer et al., 2010, Lee et al., 2010, Li et al., 2010, Liu et al., 2010, Tiefenböck et al., 2010, Zeng et al., 2010, Cliffe et al., 2009, Hyun et al., 2009, Jiang and Edgar, 2009, Ninov et al., 2009, Werz et al., 2009, Wu et al., 2009, Honegger et al., 2008, Howlett et al., 2008, Wang et al., 2008, Ahrens et al., 2007, Hall et al., 2007, Hoshizaki and Gibbs, 2007, Howlett et al., 2007, Jovceva et al., 2007, Lasko and Sonenberg, 2007, Lavery and Stern, 2007, Lavery et al., 2007, Caldwell et al., 2006, Lavery and Stern, 2006, Liu and Lehmann, 2006, Luo et al., 2006, Martin-Pena et al., 2006, Martin-Pena et al., 2006, Shiojima and Walsh, 2006, Wood et al., 2006, Caldwell et al., 2005, King-Jones and Thummel, 2005, McNeill and Bateman, 2005, Grewal and Saucedo, 2004, Leopold, 2004, Marygold et al., 2004, Scott et al., 2004, Scott et al., 2004, Bergmann and Lane, 2003, Dickson, 2003, Gumienny and Padgett, 2003, Heriche et al., 2003, Li et al., 2003, Longo and Finch, 2003, Luque et al., 2003, Neufeld, 2003, Nijhout, 2003, Saucedo et al., 2003, Stocker et al., 2003, Aigaki et al., 2002, Saucedo and Edgar, 2002, Gingras et al., 2001, Gupta and Schupbach, 2001, Halfar et al., 2001, Jünger et al., 2001, Tapon et al., 2001, Bohni et al., 1999, Keyes et al., 1999, Leevers, 1999, Spana and Perrimon, 1999, Stambolic et al., 1999)
              PI3K-92D
              (MacDougall and Leevers, 1995.10.6, MacDougall et al., 1995)
              PI3K-92E/Dp110
              (MacDougall et al., 1998)
              PI3K-Dp110
              (Cortina-Andrada et al., 2007)
              PI3K-I
              (O'Farrell et al., 2013)
              PI3K-dp110
              (Noebels et al., 2012, Saunders et al., 2003)
              PI3K92E
              (Tang et al., 2018, Jouette et al., 2017, Balakrishnan et al., 2015, Tchankouo-Nguetcheu et al., 2014, Jagut et al., 2013, Khuong et al., 2013, Nowak et al., 2013, Pickering et al., 2013, Tixier et al., 2013, Wang et al., 2013, Bridon et al., 2012, Zhai et al., 2012, Acebes et al., 2011, Eddison et al., 2011, Slack et al., 2010, Martin et al., 2007, Herranz et al., 2006)
              PI3k
              (Nässel et al., 2013, Parrish et al., 2009)
              PI3K
              (Hardie, 2003)
              Pi3K
              (Chi et al., 2019, Murcia et al., 2019, Di Cara and King-Jones, 2016, Kwon et al., 2015, Dimitroff et al., 2012, Tang et al., 2011, Li et al., 2010, Nuzhdin et al., 2009, Edgar, 2006, Papadopoulou et al., 2004)
              Pi3K92D
              Pi3K92E
              (Fahey-Lozano et al., 2019, Li et al., 2019, Moreno et al., 2019, Terrasi et al., 2019, Hauswirth et al., 2018, Im et al., 2018, Sharma et al., 2018, Sollazzo et al., 2018, Dey et al., 2017, Park et al., 2017, Transgenic RNAi Project members, 2017-, Xiang et al., 2017, Purice et al., 2016, Vinayagam et al., 2016, Aradska et al., 2015, Grotewiel and Bettinger, 2015, Li et al., 2015, Lin et al., 2015, Park et al., 2015, Ugrankar et al., 2015, Xia et al., 2015, Das et al., 2014, Schertel et al., 2013, Sopko and Perrimon, 2013, Japanese National Institute of Genetics, 2012.5.21, Korenjak et al., 2012, Tokusumi et al., 2012, Friedman et al., 2011, Zhang et al., 2011, Sun et al., 2010, Velichkova et al., 2010, Alvarez-Ponce et al., 2009, Jiang and Edgar, 2009, Kent et al., 2009, Witte et al., 2009, Branco et al., 2008, Liu and Lehmann, 2008, Qin et al., 2008, Chintapalli et al., 2007, Jordan et al., 2005)
              Pi3K92E|p110
              (Alvarez-Ponce et al., 2012)
              Pi3Kp110
              (Oldham et al., 2002)
              Pi3k
              (Kim et al., 2010)
              Pi3k92e
              (Breitkopf et al., 2016)
              PiK92E
              (Pezzulo et al., 2012)
              anon-92Ed
              dP110
              (Wittwer et al., 2005)
              dP13K
              (Kamakura, 2011)
              dPI3K
              (Pospisilik et al., 2010, Oldham et al., 2005, Jorgensen and Tyers, 2004, Kim et al., 2004, Jacinto and Hall, 2003, Lizcano et al., 2003, Manning and Cantley, 2003, Miron et al., 2003, Oldham and Hafen, 2003)
              dPI3K92E
              (Branco et al., 2008)
              dp110
              (Borreguero-Muñoz et al., 2019, Chen and Read, 2019, Chen et al., 2019, Chi et al., 2019, Portela et al., 2019, Santabárbara-Ruiz et al., 2019, Ghiglione et al., 2018, Otsuki and Brand, 2018, Read, 2018, Katheder et al., 2017, Sipe and Siegrist, 2017, Parker and Struhl, 2015, Claret et al., 2014, Claret et al., 2014, Bader et al., 2013, Buszard et al., 2013, Jagut et al., 2013, Read et al., 2013, Murray et al., 2012, Glatter et al., 2011, Read, 2011, Chell and Brand, 2010, Froldi et al., 2010, Li et al., 2010, Ninov et al., 2009, Read et al., 2009, Porstmann et al., 2008, Hall et al., 2007, Senoo-Matsuda and Johnston, 2007, Teleman and Cohen, 2006, Grewal et al., 2005, Trotta et al., 2005, Kramer et al., 2003)
              dp110α
              (Read et al., 2013)
              dpP110
              (Katheder et al., 2017)
              p110
              (Kim et al., 2018, Grotewiel and Bettinger, 2015, Eddison et al., 2011, Sousa-Nunes et al., 2011, Haberman et al., 2010, Abe et al., 2009, Sims et al., 2009, Wu et al., 2009, Wu and Brown, 2006, Shingleton, 2005, Bruckner et al., 2004, Bruckner et al., 2004, Pan et al., 2004, Burgering and Kops, 2002, Duchek and Rorth, 2001, Oldham et al., 2000)
              p120
              (Leevers et al., 1996)
              pi3k
              (Levayer et al., 2015)
              pi3k92E
              (Hirabayashi, 2016)
              pi3k92e
              (Doherty et al., 2014)
              rea
              (Maier et al., 1992)
              type-1 PI3K
              (Rorth, 2002)
              Name Synonyms
              PI 3-kinase
              (Hardie, 2003, Day and Lawrence, 2000)
              PI3 kinase
              (Slack et al., 2011, Haberman et al., 2010, Parrish et al., 2009, Lee and Orr-Weaver, 2003)
              PI3-kinase
              (Anonymous, 2006, Coelho et al., 2003, Wilson and Leptin, 2000)
              PI3K Class I
              (Abe et al., 2009)
              PI3Kinase92E
              (Khuong et al., 2013)
              Phosphatidylinositol 3-kinase 92E
              Phosphatidylinositol-3-kinase
              (Kent et al., 2009)
              Phosphoinositide-3 Kinase
              (Froldi et al., 2010)
              Phosphotidylinositol 3 kinase
              (Jiang and Edgar, 2009)
              Pi3K92E
              (Branco et al., 2008)
              class I PI(3)K
              (Orme et al., 2006)
              dPI 3-kinase
              (Marygold and Leevers, 2002)
              insulin-regulated PI3 kinase
              (Tauber et al., 2007)
              p110 PI3 kinase
              (Bohni et al., 1999)
              phosphatidylinositol 3-kinase
              (Hariharan, 2006, Papadopoulou et al., 2004)
              phosphatidylinositol-3 kinase
              (Kamakura, 2011)
              phospho-inositol-3 kinase at 92E
              (Jordan et al., 2005)
              phosphoinositide 3 kinase Dp110
              (Bridon et al., 2012)
              phosphoinositide 3-kinase
              (Lv et al., 2012, Lee et al., 2010, Werz et al., 2009, Jovceva et al., 2007, Leevers, 1996.10.25)
              Secondary FlyBase IDs
              • FBgn0014938
              Datasets (1)
              Study focus (1)
              Experimental Role
              Project
              Project Type
              Title
              • bait_protein
              PPI_InR-Tor_interaction_map
              Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
              References (477)