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General Information
Symbol
Dmel\Pi3K92E
Species
D. melanogaster
Name
Pi3K92E
Annotation Symbol
CG4141
Feature Type
FlyBase ID
FBgn0015279
Gene Model Status
Stock Availability
Enzyme Name (EC)
Phosphatidylinositol 3-kinase (2.7.1.137)
Phosphatidylinositol-4,5-bisphosphate 3-kinase (2.7.1.153)
Phosphatidylinositol-4-phosphate 3-kinase (2.7.1.154)
Gene Snapshot
Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth. [Date last reviewed: 2018-09-13]
Also Known As
Dp110, PI3K, p110, dPI3K, PI(3)K
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:20,628,972..20,634,732 [-]
Recombination map
3-69
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate (2.7.1.137)
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (2.7.1.153)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate (2.7.1.154)
Predictions / Assertions
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate (2.7.1.137)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate (2.7.1.154)
Summaries
Gene Group (FlyBase)
PHOSPHATIDYLINOSITOL KINASES -
Phosphatidylinositol kinases catalyze the phosphorylation of phosphatidylinositol or its phosphorylated derivatives. (Adapted from FBrf0227909).
CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX -
Class IA phosphoinositide 3-kinase (PI3K) is a heterodimeric complex of a regulatory and catalytic subunit and is a core component of many many signaling pathways. In vitro, PI3Ks can phosphorylate phosphatidylinositol (PtdIns), PtdIns(4)P and PtdIns(4,5)P2 to generate PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively. (Adapted from PMID:24587488 and FBrf0227909).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Summary (Interactive Fly)
an enzyme that synthesizes phosphatidylinositide lipids, which act as signals essential for growth - a target of the insulin pathway
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Pi3K92E or the JBrowse view of Dmel\Pi3K92E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083940
4420
1088
FBtr0083941
4347
1088
FBtr0334643
4839
1088
Additional Transcript Data and Comments
Reported size (kB)
3.712 (compiled cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083348
127.0
1088
7.62
FBpp0083349
127.0
1088
7.62
FBpp0306705
127.0
1088
7.62
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1088 aa isoforms: Pi3K92E-PA, Pi3K92E-PB, Pi3K92E-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
1088 (aa); 127 (kD predicted)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pi3K92E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (58 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
Biological Process (49 terms)
Terms Based on Experimental Evidence (47 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q9VA37
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005673
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005674
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pi3K92E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pi3K92E
Transgenic constructs containing regulatory region of Pi3K92E
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
cell surface & nurse cell | somatic clone, with Scer\GAL4Act5C.PP
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
 
11 of 15
No
Yes
 
6 of 15
No
Yes
3 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
11 of 15
No
Yes
6 of 15
No
Yes
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
11 of 13
Yes
Yes
10 of 13
No
Yes
3 of 13
No
Yes
2 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
6 of 12
Yes
Yes
2 of 12
No
Yes
2 of 12
No
Yes
Danio rerio (Zebrafish) (6)
11 of 15
Yes
Yes
9 of 15
No
Yes
6 of 15
No
Yes
4 of 15
No
Yes
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
10 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190179 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500SW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01HB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01FG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G027R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
2 of 10
2 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 9 )
Modifiers Based on Experimental Evidence ( 4 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
External Data
Linkouts
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-69
Cytogenetic map
Sequence location
3R:20,628,972..20,634,732 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
92F3-92F3
Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
92E12-92E13
92E12-92E13
(determined by in situ hybridisation)
92D-92D
(determined by in situ hybridisation)
92D1-92D4
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (27)
Genomic Clones (21)
cDNA Clones (112)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Pi3K92E CG4141
    Source for database merge of
    Source for merge of: Pi3K92E anon-92Ed
    Additional comments
    Other Comments
    Reduced postsynaptic Pi3K92E signaling results in reduced synapse size and increased quantal content without affecting quantal size.
    The activation of Pi3K92E by mGluRA is mediated by CaMKII and Fak56D.
    High levels of Pi3K92E signaling promote tumour growth while low levels suppress tumour growth.
    Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells.
    Pi3K92E is autonomously required for imaginal disc cells to achieve their normal adult size, regulating cells size throughout the cell cycle. Pi3K92E normally promotes cell division and/or cell survival.
    The Pi3K92E/Pi3K21B complex possesses lipid kinase activity.
    Molecular and functional analysis of Pi3K92E implies a role for Pi3K92E in growth control during development.
    Identified by PCR using degenerate primers based on regions of strong amino acid homology found within the putative lipid kinase domain of mammalian p110α and yeast Vps34p.
    Maps within 10kb of the H gene.
    Identified as a transcription unit during molecular analysis of H.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 100 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (59)
    Reported As
    Symbol Synonym
    Dp110
    (Hansen et al., 2019, Alpar et al., 2018, Poon et al., 2018, Roth et al., 2018, Das and Arur, 2017, Jordán-Álvarez et al., 2017, Liao et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Romero-Pozuelo et al., 2017, Xiang et al., 2017, Yun et al., 2017, Zheng et al., 2017, Cinnamon et al., 2016, Kučerová et al., 2016, Ejeskär et al., 2015, Panneton et al., 2015, Schmitt et al., 2015, Avet-Rochex et al., 2014, Banreti et al., 2014, Liu et al., 2014, Radermacher et al., 2014, Hahn et al., 2013, Levayer and Moreno, 2013, Shim et al., 2013, Sim and Denlinger, 2013, Subramanian et al., 2013, Avet-Rochex et al., 2012, Dahlgaard et al., 2012, Denton et al., 2012, Pallares-Cartes et al., 2012, Karpac et al., 2011, Lin et al., 2011, Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011, Partridge et al., 2011, Resnik-Docampo and de Celis, 2011, Slack et al., 2011, Zhang et al., 2011, Biteau et al., 2010, McLeod et al., 2010, Siegrist et al., 2010, Slack et al., 2010, Tiefenböck et al., 2010, Diangelo et al., 2009, Jiang and Edgar, 2009, Jones et al., 2009, Kent et al., 2009, Mirth et al., 2009, Werz et al., 2009, Wu et al., 2009, Jones and Grotewiel, 2008, Learte et al., 2008, Leevers, 2008.10.20, McNeill et al., 2008, Xu et al., 2008, Berry and Baehrecke, 2007, Hall et al., 2007, Hietakangas and Cohen, 2007, Senoo-Matsuda and . Johnston, 2007, Wells and Johnston, 2007, Anonymous, 2006, Betschinger et al., 2006, DiAngelo and Birnbaum, 2006, Fuss et al., 2006, Herranz et al., 2006, Liu and Lehmann, 2006, Orme et al., 2006, Patel and Tamanoi, 2006, Vereshchagina and Wilson, 2006, Walker et al., 2006, Williams et al., 2006, Wood et al., 2006, Coelho et al., 2005, Goberdhan et al., 2005, Lievens et al., 2005, Mikeladze-Dvali et al., 2005, Mirth et al., 2005, Mirth et al., 2005, Orme and Leevers, 2005, Partridge et al., 2005, Sustar and Schubiger, 2005, Teleman et al., 2005, Wu et al., 2005, Bateman and McNeill, 2004, MacDougall et al., 2004, Papadopoulou et al., 2004, Reiling and Hafen, 2004, Resino and Garcia-Bellido, 2004, Rusten et al., 2004, de la Cova and Johnston, 2003, Junger et al., 2003, Miron et al., 2003, Raisin et al., 2003, Saucedo et al., 2003, Williams et al., 2003, Yang and Baker, 2003, Aigaki et al., 2002, Britton et al., 2002, Claeys et al., 2002, Hennig and Neufeld, 2002, Hipfner et al., 2002, Prober and Edgar, 2002, Radimerski et al., 2002, Towers and Sattelle, 2002, Xue and Noll, 2002, Cho et al., 2001, Clancy et al., 2001, Coelho et al., 2001, Gems and Partridge, 2001, Halfar et al., 2001, Miron et al., 2001, Radimerski et al., 2001, Rintelen et al., 2001, Strauss, 2001, Tang et al., 2001, Britton and Edgar, 2000, Coelho and Leevers, 2000, Raabe, 2000, Scanga et al., 2000, Teleman and Cohen, 2000, Weinkove and Leevers, 2000, Bohni et al., 1999, Coelho and Leevers, 1999, Goberdhan et al., 1999, Leevers, 1999, Leevers et al., 1999, Moghal and Sternberg, 1999, Weinkove et al., 1999, Leevers et al., 1998, Riesgo-Escovar et al., 1998, Rommel and Hafen, 1998, Wymann and Pirola, 1998, Leevers et al., 1997, Vanhaesebroeck et al., 1997, Weinkove et al., 1997, Weinkove et al., 1997, Leevers, 1996.12.5, Leevers et al., 1996)
    PI-3-K
    PI3K
    (Hansen et al., 2019, Kim and Choi, 2019, Portela et al., 2019, Lee et al., 2018, Arnés et al., 2017, Gupta and Ray, 2017, Kim et al., 2017, Li et al., 2017, Wen et al., 2017, Yun et al., 2017, Zheng et al., 2017, Jia et al., 2015, Okamoto and Nishimura, 2015, Ugrankar et al., 2015, Homem et al., 2014, Khadilkar et al., 2014, Radermacher et al., 2014, Ibar et al., 2013, Luo et al., 2013, Nässel et al., 2013, Nirala et al., 2013, Pickering et al., 2013, Subramanian et al., 2013, Tixier et al., 2013, Wong et al., 2013, Acebes et al., 2012, Choi and Hyun, 2012, Jordán-Álvarez et al., 2012, Lv et al., 2012, Morris et al., 2012, Mozer and Sandstrom, 2012, Murray et al., 2012, Chun-Jen Lin et al., 2011, Kamakura, 2011, Zhang et al., 2011, Aron et al., 2010, Chell and Brand, 2010, Delanoue et al., 2010, Georgiev et al., 2010, Kockel et al., 2010, Kremer et al., 2010, Lee et al., 2010, Li et al., 2010, Liu et al., 2010, Tiefenböck et al., 2010, Zeng et al., 2010, Cliffe et al., 2009, Hyun et al., 2009, Jiang and Edgar, 2009, Ninov et al., 2009, Werz et al., 2009, Wu et al., 2009, Honegger et al., 2008, Howlett et al., 2008, Wang et al., 2008, Ahrens et al., 2007, Hall et al., 2007, Hoshizaki and Gibbs, 2007, Howlett et al., 2007, Jovceva et al., 2007, Lasko and Sonenberg, 2007, Lavery and Stern, 2007, Lavery et al., 2007, Caldwell et al., 2006, Lavery and Stern, 2006, Liu and Lehmann, 2006, Luo et al., 2006, Martin-Pena et al., 2006, Martin-Pena et al., 2006, Shiojima and Walsh, 2006, Wood et al., 2006, Caldwell et al., 2005, King-Jones and Thummel, 2005, McNeill and Bateman, 2005, Grewal and Saucedo, 2004, Leopold, 2004, Marygold et al., 2004, Scott et al., 2004, Scott et al., 2004, Bergmann and Lane, 2003, Dickson, 2003, Gumienny and Padgett, 2003, Heriche et al., 2003, Li et al., 2003, Longo and Finch, 2003, Luque et al., 2003, Neufeld, 2003, Nijhout, 2003, Saucedo et al., 2003, Stocker et al., 2003, Aigaki et al., 2002, Saucedo and Edgar, 2002, Gingras et al., 2001, Gupta and Schupbach, 2001, Halfar et al., 2001, Jünger et al., 2001, Tapon et al., 2001, Bohni et al., 1999, Keyes et al., 1999, Leevers, 1999, Spana and Perrimon, 1999, Stambolic et al., 1999)
    PI3K-92E/Dp110
    Pi3K92D
    anon-92Ed
    type-1 PI3K
    Name Synonyms
    PI3K Class I
    PI3Kinase92E
    Phosphatidylinositol-3-kinase
    Phosphoinositide-3 Kinase
    Phosphotidylinositol 3 kinase
    class I PI(3)K
    insulin-regulated PI3 kinase
    p110 PI3 kinase
    phosphatidylinositol 3-kinase
    phosphatidylinositol-3 kinase
    phospho-inositol-3 kinase at 92E
    phosphoinositide 3 kinase Dp110
    Secondary FlyBase IDs
    • FBgn0014938
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (463)