Gene Dmel\Pi3K92E

(MacDougall et al., 1995)

92D-92D

(determined by in situ hybridisation)

92D1-92D4

(determined by in situ hybridisation)

(MacDougall and Leevers, 1995.10.6)

92E-92E

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Pi3K92E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Pi3K92E-RA

FBtr0083940

NM_142645

4420

1088

Pi3K92E-RB

FBtr0083941

NM_169910

4347

1088

Pi3K92E-RC

FBtr0334643

NM_001275841

4839

1088

Additional Transcript Data & Comments

Reported size (kB)

3.712 (compiled cDNA)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Pi3K92E-PA

FBpp0083348

127.0

1088

7.62

NP_650902

AAF55792

Pi3K92E-PB

FBpp0083349

127.0

1088

7.62

NP_732536

AAN14359

Pi3K92E-PC

FBpp0306705

127.0

1088

7.62

NP_001262770

AGB96150

Additional Polypeptide Data & Comments

Reported size (kDa)

1088 (aa); 127 (kD predicted)

Comments

External Data

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Phosphatidylinositol 3/4-kinase, conserved site (IPR018936)

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain (IPR000341)

Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)

Phosphatidylinositol 3-kinase C2 (PI3K C2) domain (IPR002420)

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain (IPR003113)

C2 calcium/lipid-binding domain, CaLB (IPR008973)

Protein kinase-like domain (IPR011009)

Phosphatidylinositol Kinase (IPR015433)

Armadillo-type fold (IPR016024)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P91634

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex

References

inferred from physical interaction with Pi3K21B

(The modENCODE Consortium, 2010, Graveley et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		310.3
Larval Midgut		180.9
Larval Hindgut		190.9
Larval Malpighian Tubules		194.3
Larval Fat Body		250.7
Larval Salivary Gland		352.8
Larval Trachea		217.55
Larval Carcass		300.05
Adult Head		171
Adult Eye		109.5
Adult Brain		283.4
Adult Thoracic-Abdominal Ganglion		263.9
Adult Crop		254.7
Adult Midgut		182.4
Adult Hindgut		187.5
Adult Malpighian Tubules		108.4
Adult Fat Body		190
Adult Salivary Gland		212.2
Adult Heart		142.975
Adult VirginFemale Spermatheca		211.7
Adult InseminatedFemale Spermatheca		164.4
Adult Ovary		394.9
Adult Testis		91.9
Adult Male Accessory Gland		185.5
Adult Carcass		206.9
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	171
NA	Eye	109.5
NA	Brain	283.4
310.3	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	263.9
NA	Crop	254.7
180.9	Midgut	182.4
190.9	Hindgut	187.5
194.3	Malpighian Tubules	108.4
250.7	Fat Body	190
352.8	Salivary Gland	212.2
NA	Heart	142.975
217.55	Trachea	NA
NA	VirginFemale Spermatheca	211.7
NA	InseminatedFemale Spermatheca	164.4
NA	Ovary	394.9
NA	Testis	91.9
NA	Male Accessory Gland	185.5
300.05	Carcass	206.9

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		40
ovary, mated 4-day female		34
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		(40)
ovary, mated 4-day female		(34)
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		40
ovary, mated 4-day female		34
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		40
ovary, mated 4-day female		34
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		40
ovary, mated 4-day female		34
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		(40)
ovary, mated 4-day female		(34)
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		40
ovary, mated 4-day female		34
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		21
central nervous system, larvae L3		18
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		8
head, virgin 20-day female		11
head, mated 1-day female		8
head, mated 4-day female		7
head, mated 20-day female		8
head, mated 1-day male		11
head, mated 4-day male		9
head, mated 20-day male		15
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		26
digestive system, larvae L3 wandering		15
digestive system, 1-day adult		6
digestive system, 4-day adult		7
digestive system, 20-day adult		8
fat body, larvae L3 wandering		8
fat body, white prepupae		18
fat body, pupae P8		7
carcass, larvae L3 wandering		17
carcass, 1-day adult		9
carcass, 4-day adult		8
carcass, 20-day adult		10
ovary, virgin 4-day female		40
ovary, mated 4-day female		34
testis, mated 4-day male		5
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		20
embryo 04-06hr		39
embryo 06-08hr		34
embryo 08-10hr		33
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(33)
embryo 02-04hr		20
embryo 04-06hr		(39)
embryo 06-08hr		(34)
embryo 08-10hr		(33)
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		(27)
adult female 30day		(27)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		20
embryo 04-06hr		39
embryo 06-08hr		34
embryo 08-10hr		33
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		20
embryo 04-06hr		39
embryo 06-08hr		34
embryo 08-10hr		33
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		20
embryo 04-06hr		39
embryo 06-08hr		34
embryo 08-10hr		33
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(33)
embryo 02-04hr		20
embryo 04-06hr		(39)
embryo 06-08hr		(34)
embryo 08-10hr		(33)
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		20
embryo 04-06hr		39
embryo 06-08hr		34
embryo 08-10hr		33
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		20
embryo 04-06hr		39
embryo 06-08hr		34
embryo 08-10hr		33
embryo 10-12hr		21
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		15
embryo 18-20hr		17
embryo 20-22hr		16
embryo 22-24hr		21
larva L1		12
larva L2		11
larva L3 12hr old		10
larva L3 puffstage 1-2		9
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		19
white prepupae new		22
white prepupae 12hr		25
white prepupae 24hr		22
pupae 2d postWPP		16
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		10
adult male 05day		10
adult male 30day		11
adult female 01day		20
adult female 05day		27
adult female 30day		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		55
Schneider line 2 Sg4		16
embryonic 1182-4H		51
embryonic GM2		63
embryonic Kc167		28
embryonic S1		49
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		37
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		35
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		34
tumorous blood cells mbn2		53
ovary fGS/OSS		39
ovary OSC		27
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(55)
Schneider line 2 Sg4		16
embryonic 1182-4H		(51)
embryonic GM2		(63)
embryonic Kc167		(28)
embryonic S1		(49)
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		(29)
wing disc ML-DmD8		19
wing disc ML-DmD9		(37)
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		(35)
haltere disc ML-DmD17-c3		(32)
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		(34)
tumorous blood cells mbn2		(53)
ovary fGS/OSS		(39)
ovary OSC		(27)
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		55
Schneider line 2 Sg4		16
embryonic 1182-4H		51
embryonic GM2		63
embryonic Kc167		28
embryonic S1		49
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		37
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		35
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		34
tumorous blood cells mbn2		53
ovary fGS/OSS		39
ovary OSC		27
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		55
Schneider line 2 Sg4		16
embryonic 1182-4H		51
embryonic GM2		63
embryonic Kc167		28
embryonic S1		49
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		37
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		35
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		34
tumorous blood cells mbn2		53
ovary fGS/OSS		39
ovary OSC		27
ovary OSS		15
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		55
Schneider line 2 Sg4		16
embryonic 1182-4H		51
embryonic GM2		63
embryonic Kc167		28
embryonic S1		49
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		37
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		35
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		34
tumorous blood cells mbn2		53
ovary fGS/OSS		39
ovary OSC		27
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(55)
Schneider line 2 Sg4		16
embryonic 1182-4H		(51)
embryonic GM2		(63)
embryonic Kc167		28
embryonic S1		(49)
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		(37)
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		(35)
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		(34)
tumorous blood cells mbn2		(53)
ovary fGS/OSS		(39)
ovary OSC		27
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		55
Schneider line 2 Sg4		16
embryonic 1182-4H		51
embryonic GM2		63
embryonic Kc167		28
embryonic S1		49
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		37
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		35
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		34
tumorous blood cells mbn2		53
ovary fGS/OSS		39
ovary OSC		27
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		55
Schneider line 2 Sg4		16
embryonic 1182-4H		51
embryonic GM2		63
embryonic Kc167		28
embryonic S1		49
embryonic S3		23
leg disc CME L1		25
wing disc CME-W2		29
wing disc ML-DmD8		19
wing disc ML-DmD9		37
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		7
wing disc ML-DmD32		35
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		25
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		15
CNS ML-DmBG1-c1		18
CNS ML-DmBG2-c2		34
tumorous blood cells mbn2		53
ovary fGS/OSS		39
ovary OSC		27
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		(28)
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		9
heat shock, 4-day adult		14
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		19
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		25
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

External Data & Images

(Weinkove et al., 1999, Williams et al., 2006)

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0015279

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4141-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal

lethal, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

lethal | recessive

Pi3K92E^A

partially lethal - majority die, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Pi3K92E^GD11228

viable, with Scer\GAL4^Adh.PF

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

viable, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

viable (with Pi3K92E^2H1)

Pi3K92E^A

viable (with Pi3K92E^A)

Pi3K92E^2H1

viable | RU486 conditional, with Scer\GAL4^da.Switch.PT

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

Sterility

Allele

female sterile (with Pi3K92E^6M5)

Pi3K92E^6V2

female sterile (with Pi3K92E^6V2)

Pi3K92E^6M5

fertile, with Scer\GAL4^Adh.PF

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

fertile, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

semi-sterile | RU486 conditional, with Scer\GAL4^da.Switch.PT

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

Other Phenotypes

Allele

cell death defective | embryonic stage, with Scer\GAL4^unspecified

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

cell growth defective, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

cell growth defective | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

cell size defective, with Scer\GAL4⁷⁹⁶

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

cell size defective, with Scer\GAL4^amn-c651

cell size defective, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

chemical resistant, with Scer\GAL4^elav-C155

Pi3K92E^{A2860C.Scer\UAS}

chemical resistant | adult stage | heat sensitive, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

Pi3K92E^{A2860C.Scer\UAS}

chemical sensitive, with Scer\GAL4^elav-C155

Pi3K92E^{Scer\UAS.Exel}

decreased cell death, with Scer\GAL4^hs.PB

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

decreased cell number, with Scer\GAL4^dpp.blk1

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell number, with Scer\GAL4^GMR.PF

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell number, with Scer\GAL4^nub-AC-62

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell number, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

decreased cell size, with Scer\GAL4^ap-md544

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell size, with Scer\GAL4^Bx-MS1096

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell size, with Scer\GAL4^dpp.blk1

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell size, with Scer\GAL4^GMR.PF

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell size, with Scer\GAL4^nub-AC-62

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

decreased cell size, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

decreased cell size | recessive | somatic clone

Pi3K92E^A

developmental rate defective, with Scer\GAL4^amn-c651

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

developmental rate defective, with Scer\GAL4^P0206

developmental rate defective, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

developmental rate defective | third instar larval stage, with Scer\GAL4^amn-c651

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

developmental rate defective | third instar larval stage, with Scer\GAL4^amn-X8

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

feeding behavior defective, with Scer\GAL4^Adh.PF

feeding behavior defective, with Scer\GAL4^NPFR1.6.6

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

hyperplasia, with Scer\GAL4^GMR.PF

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

hyperplasia, with Scer\GAL4^nub-AC-62

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

increased cell number, with Scer\GAL4⁷⁹⁶

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

increased cell number, with Scer\GAL4^dpp.blk1

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

increased cell number, with Scer\GAL4^P0206

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

increased cell number | adult stage, with Scer\GAL4^dpp.blk1

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

increased cell size, with Scer\GAL4^AB1

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

increased cell size, with Scer\GAL4^Bx-MS1096

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

increased cell size, with Scer\GAL4^dpp.blk1

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

increased cell size | adult stage, with Scer\GAL4^dpp.blk1

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

increased cell size | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

large body, with Scer\GAL4^P0206

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

large body | adult stage, with Scer\GAL4^amn-c651

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

large body | pupal stage, with Scer\GAL4^amn-c651

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

large body | pupal stage, with Scer\GAL4^amn-X8

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

locomotor behavior defective, with Scer\GAL4⁷⁹⁶

long lived | :drug conditional | RU486 conditional, with Scer\GAL4^da.Switch.PT

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

long lived | RU486 conditional, with Scer\GAL4^bun-GSG5961

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

long lived | RU486 conditional, with Scer\GAL4^da.Switch.PT

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4⁷⁹⁶

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^C57

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^D42

neuroanatomy defective, with Scer\GAL4^da.G32

neuroanatomy defective, with Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^{exba-krasavietz}, Scer\GAL80^Mef2.PT

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^GH298

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^GH298, Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^GH298, Scer\GAL80^Cha.3.3P

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective, with Scer\GAL4^Mef2.247

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neuroanatomy defective | larval stage, with Scer\GAL4^ppk.PG

Pi3K92E^{CAAX.Scer\UAS}

neurophysiology defective, with Scer\GAL4^C57

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neurophysiology defective, with Scer\GAL4^D42

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

neurophysiology defective, with Scer\GAL4^da.G32

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

neurophysiology defective, with Scer\GAL4^elav.PLu

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

photoperiod response variant, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

planar polarity defective | recessive | somatic clone

Pi3K92E^A

planar polarity defective | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

short lived | heat sensitive, with Scer\GAL4^esg-NP5130, Scer\GAL80^ts.αTub84B

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

size defective, with Scer\GAL4^ap-md544

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

size defective, with Scer\GAL4^Bx-MS1096

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

size defective, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

size defective, with Scer\GAL4^nub-AC-62

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

size defective | adult stage, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

size defective | cell autonomous, with Scer\GAL4^dpp.blk1

size defective | cell non-autonomous, with Scer\GAL4^dpp.blk1

small body, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

small body (with Pi3K92E^2H1)

Pi3K92E^A

small body (with Pi3K92E^A)

Pi3K92E^2H1

small body | pharate adult stage, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

small body | pupal stage, with Scer\GAL4^amn-c651

Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}

small body | second instar larval stage, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

small body | somatic clone

Pi3K92E^unspecified

small body | third instar larval stage, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

smell perception defective, with Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

smell perception defective, with Scer\GAL4^{exba-krasavietz}, Scer\GAL80^Mef2.PT

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

smell perception defective, with Scer\GAL4^GH298

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

smell perception defective, with Scer\GAL4^GH298, Scer\GAL80^Cha.3.3P

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

some die during larval stage, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

some die during pupal stage, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

stress response defective, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

visible, with Scer\GAL4^ap-md544

visible, with Scer\GAL4^Bx-MS1096

visible, with Scer\GAL4^dpp.blk1

visible, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

visible, with Scer\GAL4^ey.PH

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^pnr-MD237

Pi3K92E^GD11228

visible | adult stage, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

visible | embryonic stage, with Scer\GAL4^unspecified

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

visible | somatic clone

Pi3K92E^5W3

wild-type

Pi3K92E^+t14.7

wound healing defective, with Scer\GAL4^crq.PO

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

Phenotype manifest in

Allele

1st posterior cell, with Scer\GAL4^dpp.blk1

1st posterior cell, with Scer\GAL4^ptc-559.1

adult gut | heat sensitive, with Scer\GAL4^esg-NP5130, Scer\GAL80^ts.αTub84B

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

adult gut | RU486 conditional, with Scer\GAL4^bun-GSG5961

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

antennal lobe, with Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

antennal lobe, with Scer\GAL4^GH298

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

antennal lobe, with Scer\GAL4^GH298, Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

antennal lobe glomerulus DM2, with Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

antennal lobe glomerulus DM2, with Scer\GAL4^GH298

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

antennal lobe glomerulus DM2, with Scer\GAL4^GH298, Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

autophagic vacuole, with Scer\GAL4^Lsp2.PH

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

axon, with Scer\GAL4^D42

bouton, with Scer\GAL4^C57

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

bouton, with Scer\GAL4^D42

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

bouton | supernumerary, with Scer\GAL4⁷⁹⁶

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

cell surface & nurse cell | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

chaeta, with Scer\GAL4^ap-md544

dendrite, with Scer\GAL4⁷⁹⁶

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

dendrite | larval stage, with Scer\GAL4^ppk.PG

Pi3K92E^{CAAX.Scer\UAS}

ellipsoid body, with Scer\GAL4⁷⁹⁶

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/first instar larval cuticle, with Scer\GAL4^unspecified

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

embryonic/larval digestive system | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval epidermis | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval fat body | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval Malpighian tubule | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval neuroblast, with Scer\GAL4^nab

embryonic/larval neuroblast, with Scer\GAL4^repo.PU

Pi3K92E^{A2860C.Scer\UAS}

embryonic/larval neuromuscular junction, with Scer\GAL4^elav.PLu

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval salivary gland, with Scer\GAL4^29BD

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval salivary gland, with Scer\GAL4^AB1

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval salivary gland, with Scer\GAL4^hs.PB

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

embryonic/larval salivary gland, with Scer\GAL4^nub-AC-62

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

eye, with Scer\GAL4^Bx-MS1096

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

eye, with Scer\GAL4^ey.PH

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^P0206

eye disc | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

fat body

Pi3K92E^A

fat body, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

germ band, with Scer\GAL4^Kr.PM

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

head capsule | somatic clone

Pi3K92E^5W3

imaginal disc

Pi3K92E^A

imaginal disc & cell, with Scer\GAL4^Act5C.PP

interommatidial bristle, with Scer\GAL4^GMR.PF

intrinsic neuron, with Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

intrinsic neuron, with Scer\GAL4^GH298

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

intrinsic neuron, with Scer\GAL4^GH298, Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

intrinsic neuron, with Scer\GAL4^Mef2.247

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

larva

Pi3K92E^A

lysosome, with Scer\GAL4^Lsp2.PH

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

mesothoracic tergum, with Scer\GAL4^ap-md544

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Pi3K92E^GD11228

mitotic cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

motor neuron, with Scer\GAL4^D42

mushroom body, with Scer\GAL4^{exba-krasavietz}, Scer\GAL80^ple.PK

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

mushroom body, with Scer\GAL4^Tab2-201Y

neuron | supernumerary, with Scer\GAL4⁷⁹⁶

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

ommatidial precursor cluster | somatic clone, with Scer\GAL4^Act5C.PP

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

ommatidium, with Scer\GAL4^GMR.PF

ommatidium | somatic clone

Pi3K92E^A

ovary (with Pi3K92E^6M5)

Pi3K92E^6V2

ovary (with Pi3K92E^6V2)

Pi3K92E^6M5

prothoracic gland, with Scer\GAL4^amn-c651

prothoracic gland, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

prothoracic gland, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

puparium, with Scer\GAL4^phm.PO

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

ring canal, with Scer\GAL4^P0206

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

synapse

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse, with Scer\GAL4^C57

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse, with Scer\GAL4^D42

synapse, with Scer\GAL4^da.G32

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse, with Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse, with Scer\GAL4^GH298

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse, with Scer\GAL4^GH298, Scer\GAL4^{exba-krasavietz}

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse, with Scer\GAL4^Mef2.247

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

synapse | supernumerary, with Scer\GAL4⁷⁹⁶

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

synapse | supernumerary, with Scer\GAL4^da.G32

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

wing, with Scer\GAL4^ap-md544

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^dpp.blk1

wing, with Scer\GAL4^nub-AC-62

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

wing, with Scer\GAL4^P0206

wing, with Scer\GAL4^αTub84B.PC

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

wing & cell, with Scer\GAL4^dpp.blk1

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

wing | posterior, with Scer\GAL4^en-e16E

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

wing blade, with Scer\GAL4^ap-md544

wing disc, with Scer\GAL4^29BD

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

wing disc | posterior compartment, with Scer\GAL4^en-e16E

Classical Alleles ( 10 )

For All Classical Alleles Show

Allele of Pi3K92E	Class	Mutagen	Stocks	Known lesion
Pi3K92E^A		P-element activity	3	Yes
Pi3K92E^c00368			1	--
Pi3K92E^e03435		piggyBac transposase	1	--
Pi3K92E^MB06212			1	--
Pi3K92E^2H1			0	--
Pi3K92E^5W3			0	--
Pi3K92E^6M5	hypomorphic allele - genetic evidence		0	Yes
Pi3K92E^6V2	hypomorphic allele - genetic evidence		0	Yes
Pi3K92E^B			0	--
Pi3K92E^unspecified			0	--

Alleles Carried on Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Pi3K92E	Class	Mutagen	Stocks	Known lesion
Pi3K92E^A2860C.GMR	antimorphic allele - genetic evidence	in vitro construct - regulatory fusion in vitro construct - amino acid replacement	2	Yes
Pi3K92E^{A2860C.Scer\UAS}	antimorphic allele - genetic evidence	in vitro construct - regulatory fusion in vitro construct - amino acid replacement	2	Yes
Pi3K92E^GD11228		in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Pi3K92E^{Scer\UAS.Exel}		in vitro construct - regulatory fusion	2	Yes
Pi3K92E^{t.RBD.T:Hsap\MYC}		in vitro construct - site directed mutagenesis in vitro construct - coding region fusion	2	Yes
Pi3K92E^T:Hsap\MYC		in vitro construct - genomic fragment in vitro construct - coding region fusion	2	Yes
Pi3K92E^{CAAX.Scer\UAS}	gain of function allele	in vitro construct - regulatory fusion in vitro construct - coding region fusion	1	Yes
Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}		in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement	1	Yes
Pi3K92E^GL00311		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Pi3K92E^GMR.Exel		in vitro construct - regulatory fusion	1	Yes
Pi3K92E^JF02770		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Pi3K92E^KK102291		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX}		in vitro construct - coding region fusion	1	Yes
Pi3K92E^{Scer\UAS.T:Hsap\MYC}		in vitro construct - regulatory fusion in vitro construct - coding region fusion	1	Yes
Pi3K92E^+t14.7		in vitro construct - genomic fragment	0	Yes
Pi3K92E^ACT.GMR		in vitro construct - regulatory fusion	0	Yes
Pi3K92E^CAAX.GMR	gain of function allele	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Pi3K92E^DN.GMR		in vitro construct - regulatory fusion	0	Yes
Pi3K92E^dsRNA.cUa		in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
Pi3K92E^NIG.4141R		in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Pi3K92E^Scer\UAS.cWa			0	--
Pi3K92E^wt.GMR		in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)H-B79

(Williams et al., 2006)

Df(3R)Pi3K92E^A

Df(3R)Pi3K92E-B

Partially disrupted in

Df(3R)Pi3K92E^A

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{UAS-Pi3K92E.A2860C}

P{UAS-Pi3K92E.CAAX}

P{UAS-Pi3K92E.Exel}

P{WT-Dp110}

characterization construct

P{GMR-Pi3K92E.A2860C}

P{UAS-Pi3K92E.RNAi.U}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}Pi3K92E^c00368

PBac{RB}Pi3K92E^e03435

insertion of enhancer trap binary system

Mi{ET1}Pi3K92E^MB06212

Gene Ontology: Function, Process & Cellular Component ( 40 unique terms )

Terms Based on Experimental Evidence ( 31 terms )

Molecular Function

CV term

1-phosphatidylinositol-3-kinase activity

References

inferred from direct assay

1-phosphatidylinositol-4-phosphate 3-kinase activity

inferred from direct assay

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

lipid kinase activity

inferred from direct assay

(Orme et al., 2006)

inferred from direct assay

(MacDougall et al., 2004)

SH3 domain binding

inferred from physical interaction with drk

Biological Process

CV term

(Martin-Pena et al., 2006)

References

autophagy

inferred from mutant phenotype

(Rusten et al., 2004)

dendrite morphogenesis

inferred from direct assay

entry into diapause

inferred from mutant phenotype

(Williams et al., 2006)

germ-band shortening

inferred from mutant phenotype

(Herranz et al., 2006)

instar larval development

inferred from mutant phenotype

(Caldwell et al., 2005)

larval development

inferred from mutant phenotype

(Mirth et al., 2005)

larval feeding behavior

inferred from mutant phenotype

(Wu et al., 2005)

larval salivary gland morphogenesis

inferred from mutant phenotype

(Takeo et al., 2005)

metamorphosis

inferred from mutant phenotype

(Mirth et al., 2005)

negative regulation of epidermal growth factor receptor signaling pathway

inferred from genetic interaction with aos

(MacDougall et al., 2004)

inferred from genetic interaction with Egfr

(MacDougall et al., 2004)

oogenesis

inferred from mutant phenotype

(Orme et al., 2006)

phosphatidylinositol phosphorylation

inferred from direct assay

positive regulation of imaginal disc growth

inferred from mutant phenotype

(Leevers et al., 1996, Orme et al., 2006)

positive regulation of organ growth

inferred from mutant phenotype

(Leevers et al., 1996, Scanga et al., 2000)

positive regulation of translation

inferred from mutant phenotype

(Hall et al., 2007)

regulation of cell proliferation

inferred from mutant phenotype

regulation of cell size

inferred from mutant phenotype

regulation of dendrite development

inferred from mutant phenotype

(Parrish et al., 2009)

regulation of long-term neuronal synaptic plasticity

inferred from direct assay

(Martin-Pena et al., 2006)

regulation of multicellular organism growth

inferred from mutant phenotype

(Caldwell et al., 2005, Mirth et al., 2005)

regulation of reactive oxygen species metabolic process

inferred from genetic interaction with InR

(Lee et al., 2010)

regulation of synapse structural plasticity

inferred from mutant phenotype

(Mozer and Sandstrom, 2012)

response to oxidative stress

inferred from mutant phenotype

(Yang, 2005)

synapse maturation

inferred from direct assay

(Martin-Pena et al., 2006)

synaptic growth at neuromuscular junction

inferred from mutant phenotype

(Dimitroff et al., 2012)

Cellular Component

CV term

1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex

References

inferred from physical interaction with Pi3K21B

Terms Based on Predictions or Assertions ( 17 terms )

Molecular Function

CV term

1-phosphatidylinositol-3-kinase activity

References

inferred from sequence or structural similarity with human PIK3CA

1-phosphatidylinositol-4-phosphate 3-kinase activity

non-traceable author statement

(Morrison et al., 2000)

inferred from sequence or structural similarity with human PIK3CA

phosphatidylinositol 3-kinase activity

inferred from sequence or structural similarity with human PIK3CA AND inferred from sequence or structural similarity with human PIK3CB AND inferred from sequence or structural similarity with human PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

inferred from sequence or structural similarity with NCBI:NP_005017

(FlyBase, 1992-)

inferred from sequence or structural similarity with human PIK3CA

Biological Process

CV term

insulin receptor signaling pathway

References

cell growth

traceable author statement

(Oldham and Hafen, 2003)

non-traceable author statement

(Johnston and Gallant, 2002)

traceable author statement

(Claeys et al., 2002)

phosphatidylinositol-mediated signaling

inferred from electronic annotation with InterPro:IPR002420, InterPro:IPR015433

(FlyBase Curators et al., 2004-)

phosphatidylinositol phosphorylation

inferred from sequence or structural similarity with human PIK3CA

positive regulation of cell growth

traceable author statement

(Oldham et al., 2000)

phosphorylation

non-traceable author statement

(Morrison et al., 2000)

non-traceable author statement

(Johnston and Gallant, 2002)

traceable author statement

(Bergmann and Lane, 2003)

positive regulation of cell size

traceable author statement

(Oldham et al., 2000, Bergmann and Lane, 2003)

positive regulation of growth

traceable author statement

(Oldham et al., 2000)

positive regulation of organ growth

non-traceable author statement

(Weinkove and Leevers, 2000)

regulation of cell size

non-traceable author statement

(Claeys et al., 2002)

regulation of multicellular organism growth

non-traceable author statement

(Claeys et al., 2002)

regulation of organ growth

non-traceable author statement

(Claeys et al., 2002, Potter and Xu, 2001)

Cellular Component

CV term

1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex

References

non-traceable author statement

(Mintseris et al., 2009.11.23)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

Pi3K92E - Ras85D

anti tag coimmunoprecipitation, peptide massfingerprinting

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Pi3K92E allele

Gene

References

Pi3K92E^5W3

Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}

(Junger et al., 2003)

Pi3K92E^ACT.GMR

lilli

(Tang et al., 2001)

ban

(Raisin et al., 2003)

(Kramer et al., 2003, Junger et al., 2003)

Pdk1

(Cho et al., 2001)

Pten

(Huang et al., 1999, Goberdhan et al., 1999, Gao et al., 2000)

Pi3K92E^DN.GMR

lilli

(Tang et al., 2001)

Pi3K92E^{Scer\UAS.T:Hsap\MYC}

Akt1

(Radimerski et al., 2002)

(Hennig and Neufeld, 2002)

(Kramer et al., 2003)

Pdk1

(Cho et al., 2001)

Pten

(Huang et al., 1999, Gao et al., 2000)

Rheb

(Saucedo et al., 2003)

Tor

unspecified

(Riesgo-Escovar et al., 1998, Coelho et al., 2005)

E-2fa

E-2fb

E-3a

E-3c1

E-3c4

E-3c7

e(Pi3K92E)alpha

e(Pi3K92E)beta

e(Pi3K92E)delta

e(Pi3K92E)gamma

ebi

(Goberdhan et al., 2005, Colombani et al., 2005)

InR

melt

(Teleman et al., 2005)

ncm

(Coelho et al., 2005, Coelho et al., 2005)

pix

Pten

(Goberdhan et al., 1999, Kiger et al., 2003)

rictor

(Hietakangas and Cohen, 2007)

RpL5

(Marygold et al., 2005, Coelho et al., 2005)

RpL38

(Marygold et al., 2005, Coelho et al., 2005)

RpLP1

RpS3

RpS3A

RpS5a

RpS13

RpS17

RpS21

RpS26

(Berry and Baehrecke, 2007, Coelho et al., 2005)

Tor

External Data

BioGRID - A database of protein and genetic interactions

•

67422

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0015279

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42446

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

P91634

Orthologs

OrthoDB Orthologs (62) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6Q597S

Dipteran inclusive ortholog search

EOG6F4SK3

Insect inclusive ortholog search

EOG67M0SQ

Arthropod inclusive ortholog search

EOG600003

Metazoa inclusive ortholog search

EOG6BGNNP

Orthologs in Drosophila Species (EOG6Q597S)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17984

Drosophila persimilis

Dper\GL27142

Drosophila willistoni

Dwil\GK22711

Drosophila virilis

Dvir\GJ24290

Drosophila mojavensis

Dmoj\GI22170

Drosophila grimshawi

Dgri\GH16124

Orthologs in non-Drosophila Dipterans (EOG6F4SK3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002903

Anopheles gambiae

Malaria mosquito

Agam\AGAP000018

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005543

Orthologs in non-Dipteran Insects (EOG67M0SQ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC551500

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016627

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH21286

Atta cephalotes

Leafcutter ant

Acep\ACEP19733

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO14049

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL17860

Linepithema humile

Argentine ant

Lhum\LH24494

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB24952

Solenopsis invicta

Red fire ant

Sinv\SINV19851

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001335

Bombyx mori

Silkmoth

Bmor\BGIBMGA002921

Pediculus humanus

Human body louse

Phum\PHUM169940

Tribolium castaneum

Red flour beetle

Tcas\TC011996

Orthologs in non-Insect Arthropods (EOG600003)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\petB

Ixodes scapularis

Deer tick

Isca\ISCW010469

Orthologs in non-Arthropod Metazoa (EOG6BGNNP)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\age-1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027144gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_022717gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_002836gn

Danio rerio

Zebrafish

Drer\wu:fb92a07

Danio rerio

Zebrafish

Drer\pik3cg

Danio rerio

Zebrafish

Drer\zgc:158659

Danio rerio

Zebrafish

Drer\ENSDARG00000075456

Danio rerio

Zebrafish

Drer\si:rp71-17i16.5

Danio rerio

Zebrafish

Drer\ENSDARG00000075947

Danio rerio

Zebrafish

Drer\pik3cd

Xenopus tropicalis

Western clawed frog

Xtro\pik3ca

Xenopus tropicalis

Western clawed frog

Xtro\pik3cg

Xenopus tropicalis

Western clawed frog

Xtro\pik3cb

Gallus gallus

Domestic chicken

Ggal\PIK3CA

Gallus gallus

Domestic chicken

Ggal\PIK3CB

Gallus gallus

Domestic chicken

Ggal\PIK3CG

Gallus gallus

Domestic chicken

Ggal\PIK3CD

Mus musculus

House mouse

Mmus\Pik3cd

Mus musculus

House mouse

Mmus\Pik3cg

Mus musculus

House mouse

Mmus\Pik3ca

Mus musculus

House mouse

Mmus\Pik3cb

Rattus norvegicus

Norway rat

Rnor\Pik3cb

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000009385

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000024392

Rattus norvegicus

Norway rat

Rnor\Pik3cd

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000023622

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000010458

Homo sapiens

Human

Hsap\PIK3CG

Homo sapiens

Human

Hsap\PIK3CD

Homo sapiens

Human

Hsap\ENSG00000051382

Homo sapiens

Human

Hsap\PIK3CA

Human Orthologs (4)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17984

Drosophila persimilis

Dper\GL27142

Drosophila willistoni

Dwil\GK22711

Drosophila virilis

Dvir\GJ24290

Drosophila mojavensis

Dmoj\GI22170

Drosophila grimshawi

Dgri\GH16124

Stocks & Reagents

Stocks Listed in FlyBase ( 24 )

Bloomington

25915

w¹¹¹⁸; P{Myc-Dp110}1

25914

y¹ w^*; P{WT-Dp110}2

25908

P{Dp110-CAAX}1, y¹ w^*

25916

w¹¹¹⁸; P{Myc-Dp110^RBD}1

8286

y¹ w¹¹¹⁸; P{UAS-Pi3K92E.Exel}2

8287

y¹ w¹¹¹⁸; P{UAS-Pi3K92E.Exel}3

8293

y¹ w¹¹¹⁸; P{GMR-Pi3K92E.Exel}2

Harvard

PBac{PB}Pi3K92E^c00368

PBac{RB}Pi3K92E^e03435

VDRC

v107390

P{KK102291}VIE-260B

v38986

w¹¹¹⁸ P{GD11228}v38986

v38985

w¹¹¹⁸; P{GD11228}v38985

More stocks available...

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 115 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

SD05105

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

DRSC - Results from RNAi screens.

•

FBgn0015279

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42446

Antibody Information

polyclonal

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Pi3K92E CG4141

(Gong, 1999.11)

Source for database merge of

Source for merge of: Pi3K92E anon-92Ed

(Mozer and Sandstrom, 2012)

Additional comments

Other Comments

Reduced postsynaptic Pi3K92E signaling results in reduced synapse size and increased quantal content without affecting quantal size.

The activation of Pi3K92E by mGluRA is mediated by CaMKII and Fak56D.

(Chun-Jen Lin et al., 2011)

Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body.

(Scott et al., 2004)

RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Pi3K92E is autonomously required for imaginal disc cells to achieve their normal adult size, regulating cells size throughout the cell cycle. Pi3K92E normally promotes cell division and/or cell survival.

Molecular and functional analysis of Pi3K92E implies a role for Pi3K92E in growth control during development.

The Pi3K92E/Pi3K21B complex possesses lipid kinase activity.

(MacDougall et al., 1995)

Identified by PCR using degenerate primers based on regions of strong amino acid homology found within the putative lipid kinase domain of mammalian p110α and yeast Vps34p.

Maps within 10kb of the H gene.

Identified as a transcription unit during molecular analysis of H.

(Morrison et al., 2000, Sun et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19, Qin et al., 2008, Bridon et al., 2012)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

42446

UniProtKB/TrEMBL

•

P91634

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Phosphatidylinositol 3/4-kinase, conserved site (IPR018936)

Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain (IPR000341)

Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)

Phosphatidylinositol 3-kinase C2 (PI3K C2) domain (IPR002420)

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain (IPR003113)

C2 calcium/lipid-binding domain, CaLB (IPR008973)

Protein kinase-like domain (IPR011009)

Phosphatidylinositol Kinase (IPR015433)

Armadillo-type fold (IPR016024)

Linkouts

BioGRID - A database of protein and genetic interactions

•

67422

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0015279

DRSC - Results from RNAi screens.

•

FBgn0015279

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0015279

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4141-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0015279

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42446

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

•

/newgene/pi3k1.htm

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42446

modMine - Data generated by the modENCODE project.

•

FBgn0015279

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

P91634

Synonyms & Secondary IDs ( 45 )

Reported As

Symbol Synonym

anon-92Ed

CG4141

Dmp110

(Leevers et al., 1995)

Dp110

(McNeill et al., 2008, Mirth et al., 2005, Coelho et al., 2005, Wu et al., 2005, Partridge, 2005, Sustar and Schubiger, 2005, Rusten et al., 2004, Reiling and Hafen, 2004, Bateman and McNeill, 2004, Mirth et al., 2005, Resino and Garcia-Bellido, 2004, Junger et al., 2003, Saucedo et al., 2003, Raisin et al., 2003, Yang and Baker, 2003, Radimerski et al., 2002, Miron et al., 2001, Claeys et al., 2002, Aigaki et al., 2002, Williams et al., 2003, de la Cova and Johnston, 2003, Hennig and Neufeld, 2002, Hipfner et al., 2002, Prober and Edgar, 2002, Towers and Sattelle, 2002, Xue and Noll, 2002, Britton et al., 2002, Rintelen et al., 2001, Coelho et al., 2001, Strauss, 2001, Cho et al., 2001, Gems and Partridge, 2001, Clancy et al., 2001, Halfar et al., 2001, Tang et al., 2001, Radimerski et al., 2001, Teleman and Cohen, 2000, Coelho and Leevers, 2000, Raabe, 2000, Britton and Edgar, 2000, Weinkove and Leevers, 2000, Goberdhan et al., 1999, Leevers, 1999, Weinkove et al., 1999, Bohni et al., 1999, Moghal and Sternberg, 1999, Leevers et al., 1999, Coelho and Leevers, 1999, Wymann and Pirola, 1998, Rommel and Hafen, 1998, Riesgo-Escovar et al., 1998, Leevers et al., 1998, Vanhaesebroeck et al., 1997, Weinkove et al., 1997, Weinkove et al., 1997, Leevers et al., 1997, Leevers, 1996.12.5, Leevers et al., 1996, Vereshchagina and Wilson, 2006, Wells and Johnston, 2007, Senoo-Matsuda and . Johnston, 2007, Goberdhan et al., 2005, Mikeladze-Dvali et al., 2005, Betschinger et al., 2006, Herranz et al., 2006, Anonymous, 2006, Walker et al., 2006, DiAngelo and Birnbaum, 2006, Fuss et al., 2006, Teleman et al., 2005, Liu and Lehmann, 2006, Berry and Baehrecke, 2007, Slack et al., 2010, Wood et al., 2006, Jones and Grotewiel, 2008, Hietakangas and Cohen, 2007, Miron et al., 2003, MacDougall et al., 2004, Papadopoulou et al., 2004, Scanga et al., 2000, Orme et al., 2006, Leevers, 2008.10.20, Murillo-Maldonado et al., 2011, Biteau et al., 2010, Karpac et al., 2011, Patel and Tamanoi, 2006, Diangelo et al., 2009, Mirth et al., 2009, Jones et al., 2009, Wu et al., 2009, Kent et al., 2009, Williams et al., 2006, Hall et al., 2007, Lievens et al., 2005, Werz et al., 2009, Siegrist et al., 2010, Tiefenböck et al., 2010, Jiang and Edgar, 2009, Lin et al., 2011, Resnik-Docampo and de Celis, 2011, McLeod et al., 2010, Learte et al., 2008, Xu et al., 2008, Murillo-Maldonado et al., 2011, Slack et al., 2011)

dp110

(Teleman and Cohen, 2006, Grewal et al., 2005, Kramer et al., 2003, Trotta et al., 2005, Glatter et al., 2011, Senoo-Matsuda and Johnston, 2007, Hall et al., 2007, Read et al., 2009, Ninov et al., 2009, Li et al., 2010, Froldi et al., 2010, Porstmann et al., 2008, Chell and Brand, 2010)

dP110

(Wittwer et al., 2005)

Dp110/PI3K

(Stocker et al., 2004)

dPI3K

(Jorgensen and Tyers, 2004, Oldham et al., 2005, Manning and Cantley, 2003, Jacinto and Hall, 2003, Oldham and Hafen, 2003, Miron et al., 2003, Lizcano et al., 2003, Pospisilik et al., 2010, Kim et al., 2004)

p110

(Shingleton, 2005, Burgering and Kops, 2002, Pan et al., 2004, Duchek and Rorth, 2001, Oldham et al., 2000, Bruckner et al., 2004, Bruckner et al., 2004, Sousa-Nunes et al., 2011, Wu et al., 2009, Haberman et al., 2010, Eddison et al., 2011)

p120

(Caldwell et al., 2005, King-Jones and Thummel, 2005, Grewal and Saucedo, 2004, Luque et al., 2003, Scott et al., 2004, Scott et al., 2004, Leopold, 2004, Stambolic et al., 1999, McNeill and Bateman, 2005, Nijhout, 2003, Marygold et al., 2004, Neufeld, 2003, Bergmann and Lane, 2003, Tapon et al., 2001, Saucedo and Edgar, 2002, Dickson, 2003, Gupta and Schupbach, 2001, Gumienny and Padgett, 2003, Longo and Finch, 2003, Aigaki et al., 2002, Saucedo et al., 2003, Stocker et al., 2003, Li et al., 2003, Juenger et al., 2001, Gingras et al., 2001, Halfar et al., 2001, Leevers, 1999, Spana and Perrimon, 1999, Bohni et al., 1999, Keyes et al., 1999, Martin-Pena et al., 2006, Luo et al., 2006, Liu and Lehmann, 2006, Lavery and Stern, 2006, Caldwell et al., 2006, Lavery and Stern, 2007, Howlett et al., 2007, Shiojima, 2006, Lasko and Sonenberg, 2007, Hoshizaki and Gibbs, 2007, Ahrens et al., 2007, Howlett et al., 2008, Wood et al., 2006, Lavery et al., 2007, Martin-Pena et al., 2006, Jovceva et al., 2007, Hall et al., 2007, Ninov et al., 2009, Cliffe et al., 2009, Mozer and Sandstrom, 2012, Lee et al., 2010, Hyun et al., 2009, Wu et al., 2009, Werz et al., 2009, Delanoue et al., 2010, Georgiev et al., 2010, Liu et al., 2010, Honegger et al., 2008, Jiang and Edgar, 2009, Zeng et al., 2010, Chell and Brand, 2010, Jordán-Álvarez et al., 2012, Kockel et al., 2010, Chun-Jen Lin et al., 2011, Li et al., 2010, Acebes et al., 2012, Wang et al., 2008, Choi and Hyun, 2012, Morris et al., 2012)

PI3'K

(Scanga et al., 2000)

PI3K

PI-3-K

(Davies, 2002)

Pi3K

(Edgar, 2006, Papadopoulou et al., 2004, Tang et al., 2011, Nuzhdin et al., 2009, Li et al., 2010, Dimitroff et al., 2012)

PI3k

(Parrish et al., 2009)

Pi3k

(Kim et al., 2010)

PI3K-92D

(MacDougall et al., 1995, MacDougall and Leevers, 1995.10.6)

Pi3K92D

PI3K92E

(Martin et al., 2007, Herranz et al., 2006, Zhai et al., 2012, Slack et al., 2010, Acebes et al., 2011, Eddison et al., 2011, Bridon et al., 2012)

Pi3K92E

(Jordan et al., 2005, Sun et al., 2010, Witte et al., 2009, Alvarez-Ponce et al., 2009, Liu and Lehmann, 2008, Chintapalli et al., 2007, Kent et al., 2009, Branco et al., 2008, Velichkova et al., 2010, Jiang and Edgar, 2009, Qin et al., 2008, Tokusumi et al., 2012, Korenjak et al., 2012, Japanese National Institute of Genetics, 2012.5.21)

PI3K-92E/Dp110

(MacDougall et al., 1998)

Pi3K92E|p110

(Alvarez-Ponce et al., 2012)

PI3K-Dp110

(Cortina-Andrada et al., 2007)

PI3K-dp110

(Saunders et al., 2003, Noebels et al., 2012)

PI-3 kinase

(Read and Thomas, 2008)

Pi3Kp110

(Oldham et al., 2002)

PI(3)K

(Rintelen et al., 2001, Lehner, 1999, Edgar, 1999, Fuss et al., 2007, Orme et al., 2006)

PI₃K

(Hardie, 2003)

PiK92E

(Pezzulo et al., 2012)

rea