FlyBase Gene Report: Dmel\Pi3K92E

Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 8 )

Allele

Disease

Evidence

References

Pi3K92E^2H1

model of type 2 diabetes mellitus

CEA

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^A

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^5W3

(Murillo-Maldonado et al., 2011)

Pi3K92E^5W3

model of type 2 diabetes mellitus

CEA

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^2H1

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^A

(Murillo-Maldonado et al., 2011)

Pi3K92E^A

model of type 2 diabetes mellitus

CEA with Pi3K92E^2H1

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^5W3

(Murillo-Maldonado et al., 2011)

Pi3K92E^A2860C.UAS

model of alcohol use disorder

CEA

(Eddison et al., 2011)

Pi3K92E^CAAX.UAS

model of glioblastoma multiforme

CEA with btl::Egfr^λ.UAS

(Chi et al., 2019)

Pi3K92E^UAS.Exel

model of alcohol use disorder

CEA

(Eddison et al., 2011)

model of brain glioma

CEA with btl::Egfr^λ.UAS

(Read et al., 2013, Read et al., 2009)

model of malignant glioma

CEA with btl::Egfr^λ.UAS

(Chen et al., 2019, Portela et al., 2019)

CEA with Hsap\EGFR^Δ.UAS

(Terrasi et al., 2019)

Pi3K92E^UAS.cUa

model of malignant glioma

CEA

(Witte et al., 2009)

Potential Models Based on Orthology ( 10 )

Human Ortholog

Disease

Evidence

References

PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

model of immunodeficiency 14

IEA

(FlyBase, 2019-)

PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

model of epidermal nevus

IEA

(FlyBase, 2019-)

model of CLOVES syndrome

IEA

(FlyBase, 2019-)

model of stomach cancer

IEA

(FlyBase, 2019-)

model of hepatocellular carcinoma

IEA

(FlyBase, 2019-)

model of seborrheic keratosis

IEA

(FlyBase, 2019-)

model of breast cancer

IEA

(FlyBase, 2019-)

model of lung cancer

IEA

(FlyBase, 2019-)

model of colorectal cancer

IEA

(FlyBase, 2019-)

model of ovarian cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 7 )

Allele

Disease

Interaction

References

Pi3K92E^CAAX.UAS

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Hansen et al., 2019)

Pi3K92E^{D954A.UAS.Tag:MYC}

ameliorates cancer

modeled by dlg1^GD4689, Ras85D^V12.UAS

(Katheder et al., 2017)

exacerbates Parkinson's disease

modeled by DJ-1α^dsRNA.UAS

(Yang et al., 2005)

exacerbates Huntington's disease

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Hansen et al., 2019)

Pi3K92E^UAS.Tag:MYC

ameliorates Parkinson's disease

modeled by DJ-1α^dsRNA.UAS

(Yang et al., 2005)

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Chen et al., 2003)

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

ameliorates cancer

modeled by Myc^αTub84B.PBb

(Levayer et al., 2015)

ameliorates obesity

modeled by Itpr^ka1091, Itpr^ug3

(Subramanian et al., 2013)

Pi3K92E^GD11228

ameliorates cancer

modeled by Ras85D^V12.UAS, dlg1^GD4689

(Willecke et al., 2011)

Pi3K92E^HMC05152

ameliorates prostate cancer

modeled by Ras85D^V12.UAS

(Rambur et al., 2020)

Pi3K92E^UAS.cUa

exacerbates malignant glioma

modeled by btl::Egfr^λ.UAS

(Witte et al., 2009)

model of malignant glioma

is exacerbated by btl::Egfr^λ.UAS

(Witte et al., 2009)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

15 of 15

602839

IMMUNODEFICIENCY 14; IMD14

immunodeficiency 14

PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

12 of 15

602925

PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

5 of 15

601232

PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

3 of 15

603601

OCULOSKELETODENTAL SYNDROME; OCSKD

PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

3 of 15

602838

PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

3 of 15

609001

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

protein kinase assay, autoradiography

(Weinkove et al., 1997)

Pi3K92E - Act5C

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - CG15784

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - CG30122

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Droj2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Fib

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Git

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

Pi3K92E - Hsc70-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - InR

anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry

(Vinayagam et al., 2016, Friedman et al., 2011)

Pi3K92E - Iswi

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Mec2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Nsun2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, protein kinase assay, autoradiography, pull down, anti tag western blot

(Breitkopf et al., 2016, Vinayagam et al., 2016, Glatter et al., 2011, Orme et al., 2006, Wittwer et al., 2005, Weinkove et al., 1997)

Pi3K92E - Psi

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Pvr

anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry

(Breitkopf et al., 2016, Vinayagam et al., 2016)

Pi3K92E - PyK

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Ranbp9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Ras64B

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Vega-Cuesta et al., 2020)

Pi3K92E - Ras85D

pull down, western blot, two hybrid

(Orme et al., 2006)

Pi3K92E - Rm62

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL10

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL13A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL14

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL17

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL18

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL19

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL21

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL28

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL35A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL6

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL7A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL8

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpL9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpLP1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS11

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS15

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS15Aa

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS17

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS23

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS26

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS6

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RpS9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Rpt4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - RtGEF

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

Pi3K92E - Syp

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - Zn72D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - alt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - chico

anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry

(Breitkopf et al., 2016, Vinayagam et al., 2016)

Pi3K92E - eIF3a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - eIF3b

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - eIF3c

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - eIF3m

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - eIF4A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - iPLA2-VIA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - larp

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - msn

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - ncd

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - nonA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - rin

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - rump

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - sta

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - vig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - vig2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Pi3K92E - yps

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Radimerski et al., 2002, Scanga et al., 2000)

Pi3K92E|foxo

suppressible

(Goberdhan et al., 2005)

enhanceable

(Radimerski et al., 2002)

suppressible

(Read et al., 2009)

suppressible

(Coelho et al., 2005)

suppressible

arm|fz

(Portela et al., 2019)

suppressible

arm|wg

(Portela et al., 2019)

suppressible

aru

(Eddison et al., 2011)

suppressible

bsk

(Portela et al., 2019)

enhanceable

btl::Egfr

(Witte et al., 2009)

suppressible

btl::Egfr

(Witte et al., 2009)

suppressible

Cdk4

(Read et al., 2009)

suppressible

(Liu et al., 2014)

enhanceable

(Coelho et al., 2005)

suppressible

(Li et al., 2017)

suppressible

(Read et al., 2009)

enhanceable

Dronc

(Berry and Baehrecke, 2007)

enhanceable

E-2c

(Coelho et al., 2005)

enhanceable

E-2fa

(Coelho et al., 2005)

enhanceable

E-2fb

(Coelho et al., 2005)

enhanceable

E-3c1

(Coelho et al., 2005)

enhanceable

E-3c4

(Coelho et al., 2005)

enhanceable

E-3c7

(Coelho et al., 2005)

enhanceable

ebi

(Marygold et al., 2011, Coelho et al., 2005)

suppressible

egr

(Portela et al., 2019)

suppressible

eIF4E1

(Read et al., 2009)

suppressible

FarO

(Cinnamon et al., 2016)

suppressible

(Read et al., 2009)

suppressible

(Slack et al., 2011, Colombani et al., 2005, Junger et al., 2003)

suppressible

(Portela et al., 2019)

suppressible

grnd

(Portela et al., 2019)

suppressible

(Lv et al., 2012)

enhanceable

(Lv et al., 2012)

enhanceable

(Resnik-Docampo and de Celis, 2011)

suppressible

igl

(Portela et al., 2019)

enhanceable

InR

(Coelho et al., 2005)

enhanceable

lep

(Coelho et al., 2005)

suppressible

lilli

(Tang et al., 2001)

suppressible

Max

(Read et al., 2009)

suppressible

Mmp1

(Portela et al., 2019)

suppressible

Mmp2

(Portela et al., 2019)

suppressible

Myc

(Read et al., 2009)

enhanceable

ncm

(Coelho et al., 2005)

suppressible

Nrg

(Portela et al., 2019)

enhanceable

(Cho et al., 2001)

suppressible

(Cho et al., 2001)

enhanceable

(Coelho et al., 2005, Coelho et al., 2005)

suppressible

pnt

(Read et al., 2009)

enhanceable

Prp8

(Coelho et al., 2005)

Arf79F|Pi3K92E

suppressible

(Khadilkar et al., 2014)

suppressible

(Read et al., 2009)

suppressible

(Goberdhan et al., 1999)

enhanceable

(Gao et al., 2000)

enhanceable

(Tchankouo-Nguetcheu et al., 2014)

suppressible

raptor

(Read et al., 2009)

suppressible

Ras85D

(Read et al., 2009)

suppressible

Rbf

(Read et al., 2009)

btl::Egfr|Pi3K92E

enhanceable

Rbf

(Read et al., 2009)

suppressible

Rheb

(Saucedo et al., 2003)

suppressible

rictor

(Hietakangas and Cohen, 2007)

suppressible

RIOK1

(Read et al., 2013)

suppressible

RIOK1

(Read et al., 2013)

suppressible

RIOK2

(Read et al., 2013)

suppressible

RIOK2

(Read et al., 2013)

enhanceable

RpL5

(Coelho et al., 2005)

suppressible

(Xu et al., 2008)

enhanceable

(Coelho et al., 2005)

enhanceable

RpLP1

(Coelho et al., 2005)

enhanceable

RpS3

(Coelho et al., 2005)

enhanceable

RpS3A

(Coelho et al., 2005)

enhanceable

RpS5a

(Coelho et al., 2005)

enhanceable

RpS13

(Coelho et al., 2005)

enhanceable

RpS17

(Coelho et al., 2005)

enhanceable

RpS21

(Coelho et al., 2005)

enhanceable

RpS26

(Coelho et al., 2005)

suppressible

S6k

(Read et al., 2009)

suppressible

(Lee et al., 2010)

enhanceable

(Lee et al., 2010)

suppressible

(Read et al., 2009)

suppressible

srl

(Tiefenböck et al., 2010)

btl::Egfr|Pi3K92E

enhanceable

stg

(Read et al., 2009)

suppressible

stg

(Read et al., 2009)

suppressible

Thor

(Read et al., 2009)

suppressible

(Roth et al., 2018)

enhanceable

(Coelho et al., 2005)

suppressible

(Read et al., 2009)

suppressible

(Berry and Baehrecke, 2007)

suppressible

Trpm

(Georgiev et al., 2010)

btl::Egfr|Pi3K92E

enhanceable

Tsc1

(Read et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Arf79F

suppressible

(Khadilkar et al., 2014)

suppressible

(Wen et al., 2017)

enhanceable

(Witte et al., 2009)

btl::Egfr

suppressible

(Witte et al., 2009)

CaMKII

suppressible

(Chun-Jen Lin et al., 2011)

suppressible

(Liu et al., 2014)

enhanceable

(Bohni et al., 1999)

Cul1

suppressible

(Wong et al., 2013)

suppressible

(Lin et al., 2011)

enhanceable

(Kim et al., 2010)

enhanceable

(Yang et al., 2005)

DJ-1α

suppressible

(Yang et al., 2005)

Dl|ct

suppressible

(Zhai et al., 2012)

egh

suppressible

(Dahlgaard et al., 2012)

enhanceable

(Goberdhan et al., 2005, Junger et al., 2003, Kramer et al., 2003)

suppressible

(Kramer et al., 2003)

hppy

enhanceable

(Resnik-Docampo and de Celis, 2011)

Itpr

suppressible

(Subramanian et al., 2013)

Mical

enhanceable

(Wong et al., 2013)

mir-278

suppressible

(Teleman and Cohen, 2006)

mir-305

suppressible

(Foronda et al., 2014)

mir-ban

suppressible

(Raisin et al., 2003)

enhanceable

(Lee et al., 2003)

suppressible

(Ejeskär et al., 2015)

suppressible

(Gao et al., 2000, Goberdhan et al., 1999, Huang et al., 1999)

enhanceable

(Gao et al., 2000, Huang et al., 1999)

Pvr

suppressible

(Bruckner et al., 2004)

Ras85D

suppressible

(Willecke et al., 2011)

Ras85D|dlg1

suppressible

(Katheder et al., 2017, Willecke et al., 2011)

enhanceable

(Murillo-Maldonado et al., 2011)

suppressible

(Murillo-Maldonado et al., 2011)

spidey

suppressible

(Cinnamon et al., 2016)

enhanceable