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Gene Dmel\Pros26.4

General Information
Symbol	Dmel\Pros26.4	Species	D. melanogaster
Name	Proteasome 26S subunit subunit 4 ATPase	Annotation symbol	CG5289
Feature type	protein_coding_gene	FlyBase ID	FBgn0015282
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	S4, p56
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	95C13-95C13	Sequence location	3R:19,755,595..19,757,247 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Proteasome 26S subunit subunit 4 ATPase is referred to in FlyBase by the symbol Dmel\Pros26.4 (CG5289, FBgn0015282). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; cell proliferation; cellular process; response to DNA damage stimulus; mitotic spindle organization; proteolysis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 26S proteasome subunit P45; ATPase, AAA+ type, core; ATPase, AAA-type, conserved site; ATPase, AAA-type, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult spermathecae, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1630788_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pros26.4: 13 out of 14 probes fall into this exonic region. Gene sequence location is 3R:19755595..19757247.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Guenin et al., 2010, BMC Genomics 11: 47 Sequence features BKN21532 HFA16799
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95C13-95C13   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95C12-95C13     (Fisher, 1995.10.24)
Experimentally Determined Recombination Data
Location	3- (Fisher, 1995.10.24, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pros26.4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pros26.4-RA FBtr0084520  NM_079745   1592   439
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pros26.4-PA   FBpp0083906   49.3   439   6.54     NP_524469   AAF56205
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) 26S proteasome subunit P45 (IPR005937)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202871   AA246388   AA263644   AA540512   AA697307   AA699163   AA804130   AE014297 AAF56205   AI297711   AI297740   AI297807   AI519247   AI531565   AW944256   AY058759 AAL13988   BF488691   BF491298   BF499126   BF502689   BF504102   BF506533   BG634243   BG637253   BG640412   BG641315   BI162295   BI162296   BI164461   BI164691   BI165781   BI168394   BI216333   BI216610   BI227630   BI229261   BI235860   BI363626   BI366406   BI368842   BI373513   BI376030   BI485550   BI571098   BI571114   BI571125   BI571163   BI581382   BI581915   BI581998   BI587004   BI593069   BI593164   BI604719   BI622638   BI624315   BI632549   BI633112   BI633940   BI636645   BI636859   BI638755   BI640141   BI640604   BI641473   BP549763   BQ103155   BX009769   BX017976   BX019099   BX041812   BX060993   BX067931   CA804725   CK605118   CK605119   CK658067   CK660546   CK661555   CK661869   CK661877   CO265417   CO275852   CO292090   CO295385   CO313312   CO320575   CO330796   DQ440313   EC061323   EC065218   EC076044   EC082858   EC090105   EC090375   EC201661   EC246977   EU930285   EV576919   EV599057   EV599587   GH749163   GH750025   GH752255   GH754229   GH757646   GH757807   GH759472   GH760792   GH773032   GH774302   GH775837   GH781230   GH789532   GH789945   GH793516   GH794037   GH797433   GH802206   GH802630   GH806646   GH807992   GH809402   GH812030   GH813022   GH813333   GH815889   GH819221   GH829939   GH831401   GH835041   GH835232   GH837956   GH846685   GH853216   GH853234   GH858252   GH863023   GH866754   GH868928   GH870140   GH870700   GH875115   GH876289   GH879245   GH879326   GH879754   GH882629   GH882658   GH885815   GH889833   GH891826   GH894680   GH894712   GH898351   GH898908   GH899121   GH899292   GH901443   GH906396   GH909007   GH910705   GH917403   GH929474   GH936084   GH936475   U39303 AAB34134
UniProtKB/Swiss-Prot	P48601
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015282    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015282 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015282 expression level Developmental Stage   Expression Level embryo 00-02hr    22161 embryo 02-04hr    19057 embryo 04-06hr    16974 embryo 06-08hr    11573 embryo 08-10hr    9816 embryo 10-12hr    9209 embryo 12-14hr    5510 embryo 14-16hr    5777 embryo 16-18hr    4103 embryo 18-20hr    3321 embryo 20-22hr    2724 embryo 22-24hr    2562 larva L1    4731 larva L2    10271 larva L3 12hr old    7188 larva L3 puffstage 1-2    11033 larva L3 puffstage 3-6    18778 larva L3 puffstage 7-9    26246 white prepupae new    30973 white prepupae 12hr    11474 white prepupae 24hr    11708 pupae 2d postWPP    8084 pupae 3d postWPP    6589 pupae 4d postWPP    12572 adult male 01day    9225 adult male 05day    8333 adult male 30day    8027 adult female 01day    12838 adult female 05day    13943 adult female 30day    13679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (22161) embryo 02-04hr  (19057) embryo 04-06hr  (16974) embryo 06-08hr  (11573) embryo 08-10hr  (9816) embryo 10-12hr  (9209) embryo 12-14hr  (5510) embryo 14-16hr  (5777) embryo 16-18hr  (4103) embryo 18-20hr  (3321) embryo 20-22hr  (2724) embryo 22-24hr  (2562) larva L1  (4731) larva L2  (10271) larva L3 12hr old  (7188) larva L3 puffstage 1-2  (11033) larva L3 puffstage 3-6  (18778) larva L3 puffstage 7-9  (26246) white prepupae new  (30973) white prepupae 12hr  (11474) white prepupae 24hr  (11708) pupae 2d postWPP  (8084) pupae 3d postWPP  (6589) pupae 4d postWPP  (12572) adult male 01day  (9225) adult male 05day  (8333) adult male 30day  (8027) adult female 01day  (12838) adult female 05day  (13943) adult female 30day  (13679) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (22161) embryo 02-04hr  (19057) embryo 04-06hr  (16974) embryo 06-08hr  (11573) embryo 08-10hr  (9816) embryo 10-12hr  (9209) embryo 12-14hr  (5510) embryo 14-16hr  (5777) embryo 16-18hr  (4103) embryo 18-20hr  (3321) embryo 20-22hr  (2724) embryo 22-24hr  (2562) larva L1  (4731) larva L2  (10271) larva L3 12hr old  (7188) larva L3 puffstage 1-2  (11033) larva L3 puffstage 3-6  (18778) larva L3 puffstage 7-9  (26246) white prepupae new  (30973) white prepupae 12hr  (11474) white prepupae 24hr  (11708) pupae 2d postWPP  (8084) pupae 3d postWPP  (6589) pupae 4d postWPP  (12572) adult male 01day  (9225) adult male 05day  (8333) adult male 30day  (8027) adult female 01day  (12838) adult female 05day  (13943) adult female 30day  (13679) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (22161) embryo 02-04hr  (19057) embryo 04-06hr  (16974) embryo 06-08hr  (11573) embryo 08-10hr    9816 embryo 10-12hr    9209 embryo 12-14hr    5510 embryo 14-16hr    5777 embryo 16-18hr    4103 embryo 18-20hr    3321 embryo 20-22hr    2724 embryo 22-24hr    2562 larva L1    4731 larva L2  10271 larva L3 12hr old    7188 larva L3 puffstage 1-2  (11033) larva L3 puffstage 3-6  (18778) larva L3 puffstage 7-9  (26246) white prepupae new  (30973) white prepupae 12hr  (11474) white prepupae 24hr  (11708) pupae 2d postWPP    8084 pupae 3d postWPP    6589 pupae 4d postWPP  (12572) adult male 01day    9225 adult male 05day    8333 adult male 30day    8027 adult female 01day  (12838) adult female 05day  (13943) adult female 30day  (13679) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22161 embryo 02-04hr    19057 embryo 04-06hr    16974 embryo 06-08hr    11573 embryo 08-10hr    9816 embryo 10-12hr    9209 embryo 12-14hr    5510 embryo 14-16hr    5777 embryo 16-18hr    4103 embryo 18-20hr    3321 embryo 20-22hr    2724 embryo 22-24hr    2562 larva L1    4731 larva L2    10271 larva L3 12hr old    7188 larva L3 puffstage 1-2    11033 larva L3 puffstage 3-6    18778 larva L3 puffstage 7-9    26246 white prepupae new    30973 white prepupae 12hr    11474 white prepupae 24hr    11708 pupae 2d postWPP    8084 pupae 3d postWPP    6589 pupae 4d postWPP    12572 adult male 01day    9225 adult male 05day    8333 adult male 30day    8027 adult female 01day    12838 adult female 05day    13943 adult female 30day    13679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015282 expression level Developmental Stage   Expression Level embryo 00-02hr    22161 embryo 02-04hr    19057 embryo 04-06hr    16974 embryo 06-08hr    11573 embryo 08-10hr    9816 embryo 10-12hr    9209 embryo 12-14hr    5510 embryo 14-16hr    5777 embryo 16-18hr    4103 embryo 18-20hr    3321 embryo 20-22hr    2724 embryo 22-24hr    2562 larva L1    4731 larva L2    10271 larva L3 12hr old    7188 larva L3 puffstage 1-2    11033 larva L3 puffstage 3-6    18778 larva L3 puffstage 7-9    26246 white prepupae new    30973 white prepupae 12hr    11474 white prepupae 24hr    11708 pupae 2d postWPP    8084 pupae 3d postWPP    6589 pupae 4d postWPP    12572 adult male 01day    9225 adult male 05day    8333 adult male 30day    8027 adult female 01day    12838 adult female 05day    13943 adult female 30day    13679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (22161) embryo 02-04hr  (19057) embryo 04-06hr  (16974) embryo 06-08hr  (11573) embryo 08-10hr  (9816) embryo 10-12hr  (9209) embryo 12-14hr  (5510) embryo 14-16hr  (5777) embryo 16-18hr  (4103) embryo 18-20hr  (3321) embryo 20-22hr  (2724) embryo 22-24hr  (2562) larva L1  (4731) larva L2  (10271) larva L3 12hr old  (7188) larva L3 puffstage 1-2  (11033) larva L3 puffstage 3-6  (18778) larva L3 puffstage 7-9  (26246) white prepupae new  (30973) white prepupae 12hr  (11474) white prepupae 24hr  (11708) pupae 2d postWPP  (8084) pupae 3d postWPP  (6589) pupae 4d postWPP  (12572) adult male 01day  (9225) adult male 05day  (8333) adult male 30day  (8027) adult female 01day  (12838) adult female 05day  (13943) adult female 30day  (13679) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (22161) embryo 02-04hr  (19057) embryo 04-06hr  (16974) embryo 06-08hr  (11573) embryo 08-10hr  (9816) embryo 10-12hr  (9209) embryo 12-14hr  (5510) embryo 14-16hr  (5777) embryo 16-18hr  (4103) embryo 18-20hr  (3321) embryo 20-22hr  (2724) embryo 22-24hr  (2562) larva L1  (4731) larva L2  (10271) larva L3 12hr old  (7188) larva L3 puffstage 1-2  (11033) larva L3 puffstage 3-6  (18778) larva L3 puffstage 7-9  (26246) white prepupae new  (30973) white prepupae 12hr  (11474) white prepupae 24hr  (11708) pupae 2d postWPP  (8084) pupae 3d postWPP  (6589) pupae 4d postWPP  (12572) adult male 01day  (9225) adult male 05day  (8333) adult male 30day  (8027) adult female 01day  (12838) adult female 05day  (13943) adult female 30day  (13679) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (22161) embryo 02-04hr  19057 embryo 04-06hr  16974 embryo 06-08hr  11573 embryo 08-10hr    9816 embryo 10-12hr    9209 embryo 12-14hr    5510 embryo 14-16hr    5777 embryo 16-18hr    4103 embryo 18-20hr    3321 embryo 20-22hr    2724 embryo 22-24hr    2562 larva L1    4731 larva L2  10271 larva L3 12hr old    7188 larva L3 puffstage 1-2  11033 larva L3 puffstage 3-6  18778 larva L3 puffstage 7-9  (26246) white prepupae new  (30973) white prepupae 12hr  11474 white prepupae 24hr  11708 pupae 2d postWPP    8084 pupae 3d postWPP    6589 pupae 4d postWPP  12572 adult male 01day    9225 adult male 05day    8333 adult male 30day    8027 adult female 01day  12838 adult female 05day  13943 adult female 30day  13679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22161 embryo 02-04hr    19057 embryo 04-06hr    16974 embryo 06-08hr    11573 embryo 08-10hr    9816 embryo 10-12hr    9209 embryo 12-14hr    5510 embryo 14-16hr    5777 embryo 16-18hr    4103 embryo 18-20hr    3321 embryo 20-22hr    2724 embryo 22-24hr    2562 larva L1    4731 larva L2    10271 larva L3 12hr old    7188 larva L3 puffstage 1-2    11033 larva L3 puffstage 3-6    18778 larva L3 puffstage 7-9    26246 white prepupae new    30973 white prepupae 12hr    11474 white prepupae 24hr    11708 pupae 2d postWPP    8084 pupae 3d postWPP    6589 pupae 4d postWPP    12572 adult male 01day    9225 adult male 05day    8333 adult male 30day    8027 adult female 01day    12838 adult female 05day    13943 adult female 30day    13679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015282    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015282 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult spermathecae, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015282 expression level Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut    697.2 Larval Hindgut    637.6 Larval Malpighian Tubules    1267.9 Larval Fat Body    603.8 Larval Salivary Gland    761.2 Larval Trachea    506.625 Larval Carcass    1149.75 Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body    644.8 Adult Salivary Gland    525.8 Adult Heart    824.675 Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut  (697.2) Larval Hindgut  (637.6) Larval Malpighian Tubules  (1267.9) Larval Fat Body  (603.8) Larval Salivary Gland  (761.2) Larval Trachea  506.625 Larval Carcass  (1149.75) Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body  (644.8) Adult Salivary Gland  525.8 Adult Heart  (824.675) Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary  (568) Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass  (552.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut    697.2 Larval Hindgut    637.6 Larval Malpighian Tubules  (1267.9) Larval Fat Body    603.8 Larval Salivary Gland    761.2 Larval Trachea    506.625 Larval Carcass  (1149.75) Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body    644.8 Adult Salivary Gland    525.8 Adult Heart    824.675 Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut    697.2 Larval Hindgut    637.6 Larval Malpighian Tubules    1267.9 Larval Fat Body    603.8 Larval Salivary Gland    761.2 Larval Trachea    506.625 Larval Carcass    1149.75 Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body    644.8 Adult Salivary Gland    525.8 Adult Heart    824.675 Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015282 expression level Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut    697.2 Larval Hindgut    637.6 Larval Malpighian Tubules    1267.9 Larval Fat Body    603.8 Larval Salivary Gland    761.2 Larval Trachea    506.625 Larval Carcass    1149.75 Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body    644.8 Adult Salivary Gland    525.8 Adult Heart    824.675 Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut  697.2 Larval Hindgut  637.6 Larval Malpighian Tubules  (1267.9) Larval Fat Body  603.8 Larval Salivary Gland  761.2 Larval Trachea  506.625 Larval Carcass  (1149.75) Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body  644.8 Adult Salivary Gland  525.8 Adult Heart  (824.675) Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary  568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass  552.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut    697.2 Larval Hindgut    637.6 Larval Malpighian Tubules  1267.9 Larval Fat Body    603.8 Larval Salivary Gland    761.2 Larval Trachea    506.625 Larval Carcass  1149.75 Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body    644.8 Adult Salivary Gland    525.8 Adult Heart    824.675 Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    489.4 Larval Midgut    697.2 Larval Hindgut    637.6 Larval Malpighian Tubules    1267.9 Larval Fat Body    603.8 Larval Salivary Gland    761.2 Larval Trachea    506.625 Larval Carcass    1149.75 Adult Head    248.2 Adult Eye    249.5 Adult Brain    221.8 Adult Thoracic-Abdominal Ganglion    195 Adult Crop    456.4 Adult Midgut    330.9 Adult Hindgut    352.1 Adult Malpighian Tubules    348.9 Adult Fat Body    644.8 Adult Salivary Gland    525.8 Adult Heart    824.675 Adult VirginFemale Spermatheca    298.1 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    568 Adult Testis    334.5 Adult Male Accessory Gland    332.7 Adult Carcass    552.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    248.2   NA  Eye    249.5   NA  Brain    221.8   489.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    195   NA  Crop    456.4   697.2  Midgut    330.9   637.6  Hindgut    352.1   1267.9  Malpighian Tubules    348.9   603.8  Fat Body    644.8   761.2  Salivary Gland    525.8   NA  Heart    824.675   506.625  Trachea    NA   NA  VirginFemale Spermatheca    298.1   NA  InseminatedFemale Spermatheca    294.5   NA  Ovary    568   NA  Testis    334.5   NA  Male Accessory Gland    332.7   1149.75  Carcass    552.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015282 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5289-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Pros26.4GD11600 lethal | pupal stage, with Scer\GAL4pnr-MD237 Pros26.4GD11600 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Pros26.4 Class Mutagen Stocks Known lesion Pros26.4A336 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pros26.4 Class Mutagen Stocks Known lesion Pros26.4GD11600 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Pros26.4HMS00104 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pros26.4KK101481 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pros26.4dsRNA.cWa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6196 (Ryder, 2004.4.26) Df(3R)Exel9014 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11600} NA P{KK101481} NA P{TRiP.HMS00104} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{5HPw+}Pros26.4A336 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
endopeptidase activity inferred from direct assay (Holzl et al., 2000)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (Goshima et al., 2007) cellular process inferred from mutant phenotype (Boutros et al., 2004) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) proteolysis inferred from direct assay AND inferred from sequence or structural similarity with human PSMC1 AND inferred from sequence or structural similarity with Saccharomyces RPT2 (Holzl et al., 2000) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component
CV term Evidence References
proteasome regulatory particle inferred from direct assay AND inferred from sequence or structural similarity with human PSMC1 (Holzl et al., 2000)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from sequence or structural similarity with Saccharomyces RPT2 (Holzl et al., 2000) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) ATP binding inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein catabolic process inferred from electronic annotation with InterPro:IPR005937 (FlyBase Curators et al., 2004-) proteolysis non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) ubiquitin-dependent protein catabolic process non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR005937 (FlyBase Curators et al., 2004-) proteasome complex non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) proteasome regulatory particle, base subcomplex inferred from sequence or structural similarity with Saccharomyces RPT2 (Holzl et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pros26.4 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67764 DroID - A comprehensive database of gene and protein interactions. • FBgn0015282 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42828
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17023 Dere\GG12390 Dgri\GH19692 Dmoj\GI22277 Dper\GL24166 Dpse\GA18789 Dsec\GM23527 Dsim\GD18337 Dvir\GJ24070 Dwil\GK11948 Dyak\GE10845
Curated drosophilid orthologs	Dgri\Pros26.4 (Sztal et al., 2007) Dmoj\Pros26.4 (Sztal et al., 2007) Dpse\GA18789   Dvir\Pros26.4 (Sztal et al., 2007)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012095-PA Aedes aegypti (mosquito) AGAP003215-PA Anopheles gambiae (mosquito) AGAP003216-PA Anopheles gambiae (mosquito) XP_623527.1 Apis mellifera (honey bee) XP_001948523.1 Acyrthosiphon pisum (pea aphid) At2g20140.1 Arabidopsis thaliana (wall cress) At4g29040.1 Arabidopsis thaliana (wall cress) 32324 Batrachochytrium dendrobatidis (chytrid fungus) 119863 Branchiostoma floridae (lancelet) 123934 Branchiostoma floridae (lancelet) BGIBMGA004908-PA Bombyx mori (silk worm) ENSBTAP00000007135 Bos taurus (bovine) CAL0005257 Candida albicans (a form of yeast) CN12463 Caenorhabditis brenneri (small nematode) CBP02269 Caenorhabditis briggsae (nematode) CE09799 Caenorhabditis elegans (worm) ENSCAFP00000025789 Canis familiaris (dog) CAGL0I04884g Candida glabrata (haploid yeast) Chro.40138 Cryptosporidium hominis (obligate parasite) ENSCINP00000007310 Ciona intestinalis (sea squirt) JA07431 Caenorhabditis japonica (nematode) CMJ186C Cyanidioschyzon merolae (red alga) cn05306 Cryptococcus neoformans (yeast-like fungus) cgd4_1170 Cryptosporidium parvum (protozoan parasite) CPIJ011552 Culex pipens (mosquito) ENSCPOP00000002207 Cavia porcellus (guinea pig) 114526 Chlamidomonas reinhardtii (green alga) RP20821 Caenorhabditis remanei (nematode) ENSCSAVP00000009460 Ciona savignyi (sedentary tunicate) 160726 Capitella spl (polychaete worm) DDB0232964 Dictyostelium discoideum (amoeba) DEHA2C04972g Debaryomyces Hansenii (yeast) 306388 Daphnia pulex (daphnia) ENSDARP00000030555 Danio rerio (zebra fish) ENSECAP00000002532 Equus caballus (horse) XP_653833 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000006879 Gymnopilus aculeatus (mushroom) ENSGALP00000017347 Gallus gallus (chicken) GL50803_113554 Giardia lamblia (flagellated protozoan) 185636 Hypsipyla robusta (cedar shoot borer) ENSP00000261303 Homo sapiens (human) ISCW018294-PA Ixodes scapularis (deer tick) KLLA0F14707g Kluyveromyces lactis (yeast) 197242 Lottia gigantea (owl limpet) LmjF13.1090 Leishmania major (virus) 23782 Monocosta brevicollis (choanoflagellate) ENSMODP00000003311 Monodelphis domestica (gray opossum) ENSMMUP00000030273 Macaca mulatta (rhesus monkey) ENSMMUP00000036049 Macaca mulatta (rhesus monkey) ENSMUSP00000021595 Mus musculus (house mouse) 176351 Nematostella vectensis (starlet anemone) XP_001604655.1 Nasonia vitripennis (wasp) ENSOANP00000006833 Ornithorynchus anatinus (platypus) ENSORLP00000019820 Oryzias latipes (japanese killifish) LOC_Os03g18690.1 Oryza sativa (asian rice) 23484 Ostreococcus tauri (green alga) PF10_0081 Plasmodium falciparum (protozoal parasite) PHUM004132-PA Pediculus humanus (human body louse) PP15177 Pristionchus pacificus (nematode) 175379 Physcomitrella patens (moss) ENSPPYP00000023570 Pongo pygmaeus (orangutan) 71237 Phytophthora ramorum (sudden oak death pathogen) 108382 Phytophthora sojae (root rot pathogen) 830601 Populus trichocarpa (black cottonwood) ENSPTRP00000011273 Pan troglodytes (chimpanzee) PVX_094615 Plasmodium vivax (protozoal parasite) ENSRNOP00000005329 Rattus norvegicus (norway rat) 148021 Sorghum bicolor (sorghum) YDL007W Saccharomyces cerevisiae (budding yeast) Smp_173840 Schistosoma mansoni (trematode parasite) SPBC4.07c Schizosaccharomyces pombe (fission yeast) XP_001175544.1 Strongylocentrotus purpuratus (purple sea urchin) 36673 Trichoplax adhaerens (metazoa) TA05950 Theileria annulata (apicomplexan parasite) XP_974859.1 Tribolium castaneum (red flour beetle) Tc00.1047053511047.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511859.180 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012586 Tetraodon nigroviridis (green spotted pufferfish) TP01_0845 Theileria parva (parasitic protozoan) 39157 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009215 Takifugu rubripes (pufferfish Takifugu) 82736.m00182 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000034242 Xenopus tropicalis (frog) YALI0F02585g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15169 LH21770 ISCW018294 FBgn0228682 FBgn0213959 FBgn0211155 FBgn0189866 FBgn0178393 JGI_V11_306388 FBgn0078789 FBgn0161756 FBgn0145005 FBgn0127156 FBgn0104678 FBgn0094042 CPIJ011552 BGIBMGA004908 ACYPI009001 GB15218 AGAP003216 AGAP003215 AAEL012095 PB21288 PHUM546010 GLEAN_09675
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	34795 y1 sc* v1; P{TRiP.HMS00104}attP2 16094 y1 w1118; PBac{5HPw+}Pros26.4A336
VDRC	v105973 P{KK101481}VIE-260B v22052 w1118; P{GD11600}v22052 v41435 w1118; P{GD11600}v41435
Genomic Clones ( 1 )
	BACR05C11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 152 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD02658
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05394 AT09035 AT13622 AT18488 AT24273 AT28006 AT30388 GM12920 HL02228 HL07832 LD03216 LD05523 LD06815 LD20221 LD38765 LP12076 LP12110 LP12196 LP14604 LP19187 LP21151 LP21637 LP21652 RE01656 RE04139 RE04415 RE05739 RE09116 RE23431 RE23809 RE24733 RE27011 RE31809 RE48525 RE51934 RE54886 RE60823 RE63950 RE68906 RH05916 RH05932 RH05946 RH05987 RH10960 RH11114 RH18767 RH19746 RH19859 RH27253 RH54542 RH63855 RH70171 SD11425 SD12634 SD15158 SD18389 SD18692 SD21127 SD22939 SD23533 SD24821 SD26357 SD27101 SD28147
Other clones	31951 71345 79805 98513 106726 181818 193073 CK01.142B.E2 Dmel_dig_003938_0710_1938 Dmel_neb_010103_0881_2272 Dmel_neb_013979_0826_3366 EK118949 EK142615 EK199152 EK209719 EK232112 EK286326 EK296211 ESG0115a.B21_A05 FGM103D01 RP003004572 RP003005198 RP003033164 RP003043398 RP003043575 RP003044451 RP003051756 RP003055075 RP003068204 RP003068551 RP003095517 RP003108231 RP003117917 RP003122683 RP003131040 RP003134636 RP003138317 RP003145833 RP003148362 RP003165114 RP003173017 RP003173575 RP003179708 RP003184660 RP003192243 RP003208401 RP003212545 RP003220490 RP003254398 RP003261081 RP003265142 RP003267935 RP003269653 RP003283005 RP003293297 RP003318075 RP003324956 RP003347787 RP003357795 RP003364291 RP003369784 RP003395118 RP003397818 RP003407226 RP003438919 RP003444654 RP003453658 RP003456886 RP003467849 RP003470112 RP003483019 RP003485079 RP003496310 RP003533700 RP003539126 RP003540607 RP003549374 RP003570559 RP003589325 RP003590811 RP003629160 RP003630916 RP003636491 RP003656879 RP003666327 UT01690 UUGC0553
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015282 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42828
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pros26.4 CG5289 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of short, monastral spindles and severe proliferation defects when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) p50, p48 and p42b subunits of the regulator complex are selectively protected against proteolysis in a reconstituted 26S protease. (Haracska and Udvardy, 1996) The 26S proteolytic complex, a multiprotein complex containing many subunits (including those encoded by Pros26.4, Pros54 and Mov34), can be assembled from two smaller multiprotein complexes, the μ particle and the 20S proteasome, by a process that requires ATP. (Udvardy, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079745 RefSeq (Proteins) • NP_524469 DDBJ / EMBL / GenBank • AAB34134 AAF56205 AAL13988 AI531565 AW944256 AY058759 U39303 Entrez Gene - A searchable database of RefSeq genes. • 42828 UniProtKB/Swiss-Prot • P48601
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) 26S proteasome subunit P45 (IPR005937)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67764 DroID - A comprehensive database of gene and protein interactions. • FBgn0015282 DRSC - Results from RNAi screens. • FBgn0015282 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015282 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5289-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015282 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 98940 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42828 InParanoid A subset of ortholog calls from InParanoid. • AAEL012095-PA Aedes aegypti (mosquito) AGAP003215-PA Anopheles gambiae (mosquito) AGAP003216-PA Anopheles gambiae (mosquito) XP_623527.1 Apis mellifera (honey bee) XP_001948523.1 Acyrthosiphon pisum (pea aphid) At2g20140.1 Arabidopsis thaliana (wall cress) At4g29040.1 Arabidopsis thaliana (wall cress) 32324 Batrachochytrium dendrobatidis (chytrid fungus) 119863 Branchiostoma floridae (lancelet) 123934 Branchiostoma floridae (lancelet) BGIBMGA004908-PA Bombyx mori (silk worm) ENSBTAP00000007135 Bos taurus (bovine) CAL0005257 Candida albicans (a form of yeast) CN12463 Caenorhabditis brenneri (small nematode) CBP02269 Caenorhabditis briggsae (nematode) CE09799 Caenorhabditis elegans (worm) ENSCAFP00000025789 Canis familiaris (dog) CAGL0I04884g Candida glabrata (haploid yeast) Chro.40138 Cryptosporidium hominis (obligate parasite) ENSCINP00000007310 Ciona intestinalis (sea squirt) JA07431 Caenorhabditis japonica (nematode) CMJ186C Cyanidioschyzon merolae (red alga) cn05306 Cryptococcus neoformans (yeast-like fungus) cgd4_1170 Cryptosporidium parvum (protozoan parasite) CPIJ011552 Culex pipens (mosquito) ENSCPOP00000002207 Cavia porcellus (guinea pig) 114526 Chlamidomonas reinhardtii (green alga) RP20821 Caenorhabditis remanei (nematode) ENSCSAVP00000009460 Ciona savignyi (sedentary tunicate) 160726 Capitella spl (polychaete worm) DDB0232964 Dictyostelium discoideum (amoeba) DEHA2C04972g Debaryomyces Hansenii (yeast) 306388 Daphnia pulex (daphnia) ENSDARP00000030555 Danio rerio (zebra fish) ENSECAP00000002532 Equus caballus (horse) XP_653833 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000006879 Gymnopilus aculeatus (mushroom) ENSGALP00000017347 Gallus gallus (chicken) GL50803_113554 Giardia lamblia (flagellated protozoan) 185636 Hypsipyla robusta (cedar shoot borer) ENSP00000261303 Homo sapiens (human) ISCW018294-PA Ixodes scapularis (deer tick) KLLA0F14707g Kluyveromyces lactis (yeast) 197242 Lottia gigantea (owl limpet) LmjF13.1090 Leishmania major (virus) 23782 Monocosta brevicollis (choanoflagellate) ENSMODP00000003311 Monodelphis domestica (gray opossum) ENSMMUP00000030273 Macaca mulatta (rhesus monkey) ENSMMUP00000036049 Macaca mulatta (rhesus monkey) ENSMUSP00000021595 Mus musculus (house mouse) 176351 Nematostella vectensis (starlet anemone) XP_001604655.1 Nasonia vitripennis (wasp) ENSOANP00000006833 Ornithorynchus anatinus (platypus) ENSORLP00000019820 Oryzias latipes (japanese killifish) LOC_Os03g18690.1 Oryza sativa (asian rice) 23484 Ostreococcus tauri (green alga) PF10_0081 Plasmodium falciparum (protozoal parasite) PHUM004132-PA Pediculus humanus (human body louse) PP15177 Pristionchus pacificus (nematode) 175379 Physcomitrella patens (moss) ENSPPYP00000023570 Pongo pygmaeus (orangutan) 71237 Phytophthora ramorum (sudden oak death pathogen) 108382 Phytophthora sojae (root rot pathogen) 830601 Populus trichocarpa (black cottonwood) ENSPTRP00000011273 Pan troglodytes (chimpanzee) PVX_094615 Plasmodium vivax (protozoal parasite) ENSRNOP00000005329 Rattus norvegicus (norway rat) 148021 Sorghum bicolor (sorghum) YDL007W Saccharomyces cerevisiae (budding yeast) Smp_173840 Schistosoma mansoni (trematode parasite) SPBC4.07c Schizosaccharomyces pombe (fission yeast) XP_001175544.1 Strongylocentrotus purpuratus (purple sea urchin) 36673 Trichoplax adhaerens (metazoa) TA05950 Theileria annulata (apicomplexan parasite) XP_974859.1 Tribolium castaneum (red flour beetle) Tc00.1047053511047.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511859.180 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012586 Tetraodon nigroviridis (green spotted pufferfish) TP01_0845 Theileria parva (parasitic protozoan) 39157 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009215 Takifugu rubripes (pufferfish Takifugu) 82736.m00182 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000034242 Xenopus tropicalis (frog) YALI0F02585g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42828 modMine - Data generated by the modENCODE project. • FBgn0015282 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15169 LH21770 ISCW018294 FBgn0228682 FBgn0213959 FBgn0211155 FBgn0189866 FBgn0178393 JGI_V11_306388 FBgn0078789 FBgn0161756 FBgn0145005 FBgn0127156 FBgn0104678 FBgn0094042 CPIJ011552 BGIBMGA004908 ACYPI009001 GB15218 AGAP003216 AGAP003215 AAEL012095 PB21288 PHUM546010 GLEAN_09675
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	5289 (Ravi et al., 2009) CG5289 (Fouix et al., 2003, Goshima et al., 2007, Barbash and Lorigan, 2007, Keleman et al., 2009.8.5, Ma et al., 2002, Ni et al., 2011.7.19) Dm_Rpt2 (Wollenberg and Swaffield, 2001) DmP26S4 (Frohlich, 2001) Dm-S4-1 (Maier et al., 2008) dRpt2 (Wojcik and DeMartino, 2002) P26s4 (Hoyle and Fisher, 1996) p54 (Adam et al., 2004) p56 (Sumegi et al., 2003, Kurucz et al., 2002, Holzl et al., 2000, Ma et al., 2002) pros26.4 (Ceriani et al., 2002) Pros26.4 (Stuart et al., 2007, Hoopfer et al., 2008, Goshima et al., 2007, Mueller et al., 2006, Maier et al., 2008, Somma et al., 2008, Chittaranjan et al., 2009, Barbash and Lorigan, 2007, Akimana et al., 2010, Zhou et al., 2008, Wasbrough et al., 2010, Guenin et al., 2010) Rpt2 (Ma et al., 2002) S4 (Muller et al., 2003, Maier et al., 2001, Holzl et al., 2000, Swaffield and Purugganan, 1997, Ma et al., 2002) unnamed (Udvardy, 1993)
Name Synonym	26S proteasome subunit 4 ATPase (Fisher, 1995.10.24) proteasome 26S (Haracska and Udvardy, 1996) Proteasome 26S subunit subunit 4 ATPase
Secondary FlyBase IDs
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Akimana et al., 2010, PLoS ONE 5(6): e11025 Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. [FBrf0211060] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Guenin et al., 2010, BMC Genomics 11: 47 Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. [FBrf0210012] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...