FB2020_06, released Dec 22, 2020

Gene: Dmel\RpL22

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General Information
Symbol
Dmel\RpL22
Species
D. melanogaster
Name
Ribosomal protein L22
Annotation Symbol
CG7434
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015288
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. [Date last reviewed: 2018-09-20]
Other Summaries
Also Known As

L22, eRpL22, EG:BACR19J1.4

Key Links
Genomic Location
Cytogenetic map
1C4-1C4
Sequence location
X:762,560..765,130 [-]
Recombination map

1-0

RefSeq locus
NC_004354 REGION:762560..765130
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables structural constituent of ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000007073
(assigned by GO_Central )
(Gaudet et al., 2011)
enables structural constituent of ribosome
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000007073
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in cytoplasmic translation
inferred by curator from GO:0022626
(Alonso and Santaren, 2006)
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000007073
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of cytosolic large ribosomal subunit
traceable author statement
(Marygold et al., 2007)
located_in ribosome
inferred from electronic annotation with InterPro:IPR002671
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eukaryotic ribosomal protein eL22 family. (P50887)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\RpL22 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RpL22-RA
FBtr0070148
NM_057786
1100
299
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
RpL22-PA
FBpp0070143
30.6
299
10.85
NP_477134
AAF45546
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL22 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Kearse et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Kearse et al., 2011)
Additional Descriptive Data

RpL22 is ubiquitously expressed in the adult male reproductive system.

(Kearse et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RpL22 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RpL22
Transgenic constructs containing regulatory region of RpL22
Deletions and Duplications ( 4 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RPL22
12 of 15
Yes
Yes
1  
Hsap\RPL22L1
9 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rpl22
12 of 15
Yes
Yes
Mmus\Rpl22l1
8 of 15
No
Yes
Mmus\Gm9457
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Rpl22
10 of 13
Yes
Yes
Rnor\Rpl22l1
8 of 13
No
Yes
Rnor\LOC100360057
5 of 13
No
Yes
Rnor\LOC103695069
1 of 13
No
Yes
Rnor\Rpl22l2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\rpl22l1
8 of 12
Yes
Yes
Xtro\rpl22
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\rpl22l1
8 of 15
Yes
Yes
Drer\rpl22
7 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rpl-22
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT3G05560
7 of 9
Yes
Yes
Atha\AT5G27770
7 of 9
Yes
Yes
Atha\AT1G02830
6 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RPL22A
12 of 15
Yes
Yes
Scer\RPL22B
11 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rpl22
9 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190JO1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD27014
Drosophila sechellia
Dsec\GM19023
Drosophila erecta
Dere\GG12744
Drosophila yakuba
Dyak\GE16569
Drosophila ananassae
Dana\GF22220
Drosophila pseudoobscura pseudoobscura
Dpse\GA20348
Drosophila persimilis
Dper\GL13062
Drosophila willistoni
Dwil\GK10059
Drosophila virilis
Dvir\GJ14723
Drosophila mojavensis
Dmoj\GI15434
Drosophila grimshawi
Dgri\GH12600
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150EO5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025724
Glossina morsitans
Tsetse fly
Gmor\GMOY001403
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01795
Mayetiola destructor
Hessian fly
Mdes\Mdes010162
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007771
Anopheles darlingi
American malaria mosquito
Adar\ADAC001591
Anopheles gambiae
Malaria mosquito
Agam\Rpl22
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004935
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0LTJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\RpL22
Danaus plexippus
Monarch butterfly
Dple\DPOGS210861-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007829
Apis florea
Little honeybee
Aflo\2277714756
Apis mellifera
Western honey bee
Amel\RpL22
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19680
Bombus terrestris
Buff-tailed bumblebee
Bter\15206148
Linepithema humile
Argentine ant
Lhum\LH16885
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001169
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012602
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10899
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15654
Pediculus humanus
Human body louse
Phum\PHUM115910
Rhodnius prolixus
Kissing bug
Rpro\RPRC014436
Cimex lectularius
Bed bug
Clec\CLEC002364
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13858
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0L3B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005128
Ixodes scapularis
Black-legged tick
Isca\ISCW011505
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72359.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g05430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_61794
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0POE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rpl22
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000017452
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001380
Gallus gallus
Domestic chicken
Ggal\RPL22
Gallus gallus
Domestic chicken
Ggal\RPL22L1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
RpL22-like
7 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RPL22; ribosomal protein L22
    12 of 15
    180474
         
        RPL22L1; ribosomal protein L22 like 1
        9 of 15
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            RpL22 - AGO1
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - AGO2
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - CG14074
            two hybrid
            (Hu et al., 2017.6.13)
            RpL22 - Dredd
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            RpL22 - Fmr1
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - Rack1
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL10
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL10Ab
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL11
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL12
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL13
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL13A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL14
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL15
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL17
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL18
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL18A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL19
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL21
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL23
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL23A
            cosedimentation, Identification by mass spectrometry, electron microscopy, anti bait coimmunoprecipitation, western blot
            (Mageeney and Ware, 2019, Anger et al., 2013)
            RpL22 - RpL24
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL26
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL27
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL27A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL28
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL29
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL3
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL30
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL31
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL32
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL34a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL35
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL35A
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL36
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL36A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL37A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL37a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL38
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL39
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL4
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL40
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL41
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL5
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL6
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL7
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL7A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL8
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL9
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpLP0
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpLP1
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpLP2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS10a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS11
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS12
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS13
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS14a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS14b
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS15
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS15Aa
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS16
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS17
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS18
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS19a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS20
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS21
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS23
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS24
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS25
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS26
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS27
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS27A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS28b
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS29
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS3
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS30
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS3A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS4
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS5a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS6
            cosedimentation, Identification by mass spectrometry, electron microscopy, bimolecular fluorescence complementation, fluorescence microscopy
            (Al-Jubran et al., 2013, Anger et al., 2013)
            RpL22 - RpS7
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS8
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS9
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - Ubx
            two hybrid
            (Hsiao et al., 2014)
            RpL22 - eEF2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - jigr1
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            RpL22 - smt3
            anti bait coimmunoprecipitation, anti tag western blot, covalent binding
            (Kearse et al., 2013)
            RpL22 - sta
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - vig
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - vig2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RNA-protein
            Physical Interaction
            Assay
            References
            RpL22 - 18SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 28SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 2SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 5.8SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 5SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - hpRNA:CR46342
            anti tag coimmunoprecipitation, northern blot
            (Zhou et al., 2008)
            RpL22 - mir-ban
            anti tag coimmunoprecipitation, northern blot
            (Zhou et al., 2008)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            RpL22
            suppressible
            RpL22-like
            (Mageeney et al., 2018)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map

            1-0

            Cytogenetic map
            1C4-1C4
            Sequence location
            X:762,560..765,130 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            1C4-1C4
            Limits computationally determined from genome sequence between P{EP}sdkEP369 and P{EP}EP1600&P{EP}EP1498
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            1-0

            (FlyBase, 2016)

            1-0.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (6)
            Genomic Clones (7)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (767)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Gershman et al., 2020, Kearse et al., 2011)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: RpL22 CG7434

              (Nusskern, 1999.11)
              Source for database merge of
              Additional comments

              "l(1)G0451" may affect "RpL22". "l(1)G0115" may affect "RpL22". "l(1)G0422" may affect "RpL22".

              (Peter et al., 2002)
              Other Comments

              RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

              (Goshima et al., 2007)

              Not a Minute gene.

              (Marygold et al., 2007)

              Deletions removing RpL22 but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

              (Marygold et al., 2007)

              Molecularly-defined mutations in RpL22 do not result in Minute phenotypes.

              (Marygold et al., 2007)

              RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

              (Boutros et al., 2004)

              Identification: Protein that interacts with the AM domain of Parp protein.

              (Koyama et al., 1999)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 43 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (18)
              Reported As
              Symbol Synonym
              CG7434
              (Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Schertel et al., 2013, Chen et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Müller et al., 2010, Zhang et al., 2010, Blagden et al., 2009, Keleman et al., 2009.8.5, Worringer et al., 2009, Goshima et al., 2007, Marygold et al., 2007, Stuart et al., 2007, Cermelli et al., 2006, Shigenobu et al., 2006, Huang et al., 2005, Kai et al., 2005, Huang et al., 2004, Benos, 2000.12.13)
              EG:BACR19J1.4
              (Benos et al., 2001, Benos, 2000.12.13)
              L22
              (Miwa et al., 2020, Ramond et al., 2020, Al-Jubran et al., 2013, Yu and Wolfner, 1998)
              PBP-12
              (Koyama et al., 1999)
              RL22
              (Mushegian et al., 1998)
              RL22_DROME
              (Fukuyama et al., 2012)
              RPL22
              (Fukuyama et al., 2013, Pinnola et al., 2007)
              Rp L22
              (Alonso and Santaren, 2006)
              RpL22
              (Jin et al., 2020, Parker et al., 2020, Polymenis, 2020, Hu et al., 2017.6.13, May and Zwaan, 2017, Chlamydas et al., 2016, Angrisani et al., 2015, Dent et al., 2015, Lin et al., 2015, Miettinen and Björklund, 2015, Vedanayagam and Garrigan, 2015, Hsiao et al., 2014, Majzoub et al., 2014, Handler et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Friedman et al., 2011, Kallappagoudar et al., 2010, Müller et al., 2010, Nie et al., 2009, Worringer et al., 2009, Zhou et al., 2008, Goshima et al., 2007, Marygold et al., 2007, Stuart et al., 2007, Beller et al., 2006, Cermelli et al., 2006, Shigenobu et al., 2006, Shigenobu et al., 2006, Otsuki et al., 2004)
              Rpl22
              (Hasygar and Hietakangas, 2014, Conrad et al., 2012, Raja et al., 2010, Glover, 1995.12.7)
              anon-EST:Posey53
              eRpL22
              (Gershman et al., 2020, Mageeney and Ware, 2019, Mageeney et al., 2018)
              rpL22
              (Kearse et al., 2011, Karandikar et al., 2003, Zhao et al., 2002)
              rpl22
              (Hallacli et al., 2012, Koyama, 1998.7.24)
              Name Synonyms
              60S RIBOSOMAL PROTEIN L22
              (Hull et al., 2015)
              PARP-binding protein-12
              (Koyama et al., 1999)
              Ribosomal protein L22
              (Fukuyama et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Cho et al., 2005)
              ribosomal protein L22
              (Huang et al., 2004)
              Secondary FlyBase IDs
              • FBgn0025289
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (112)