FB2022_02, released March 29, 2022

Gene: Dmel\RpL22

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General Information
Symbol
Dmel\RpL22
Species
D. melanogaster
Name
Ribosomal protein L22
Annotation Symbol
CG7434
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015288
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

L22, eRpL22, EG:BACR19J1.4

Key Links
Genomic Location
Cytogenetic map
1C4-1C4
Sequence location
Recombination map
1-0
RefSeq locus
NC_004354 REGION:762560..765130
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables structural constituent of ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
inferred from direct assay
(Anger et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000007073
(assigned by GO_Central )
(Gaudet et al., 2011)
enables structural constituent of ribosome
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000007073
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in cytoplasmic translation
inferred by curator from GO:0022626
(Anger et al., 2013, Alonso and Santaren, 2006)
inferred from biological aspect of ancestor with PANTHER:PTN000007073
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Marygold et al., 2007)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
inferred from direct assay
(Anger et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of cytosolic large ribosomal subunit
traceable author statement
(Marygold et al., 2007)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eukaryotic ribosomal protein eL22 family. (P50887)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. [Date last reviewed: 2018-09-20]
Gene Group (FlyBase)
CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\RpL22 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P50887)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RpL22-RA
FBtr0070148
NM_057786
1100
299
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
RpL22-PA
FBpp0070143
30.6
299
10.85
NP_477134
AAF45546
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL22 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Kearse et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Kearse et al., 2011)
Additional Descriptive Data

RpL22 is ubiquitously expressed in the adult male reproductive system.

(Kearse et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
inferred from direct assay
(Anger et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RpL22 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RpL22
Transgenic constructs containing regulatory region of RpL22
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RPL22
12 of 15
Yes
Yes
1  
Hsap\RPL22L1
9 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rpl22
12 of 15
Yes
Yes
Mmus\Rpl22l1
8 of 15
No
Yes
Mmus\Gm9457
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Rpl22
10 of 13
Yes
Yes
Rnor\Rpl22l1
8 of 13
No
Yes
Rnor\LOC100360057
5 of 13
No
Yes
Rnor\LOC103695069
1 of 13
No
Yes
Rnor\Rpl22l2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\rpl22l1
8 of 12
Yes
Yes
Xtro\rpl22
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\rpl22l1
8 of 15
Yes
Yes
Drer\rpl22
7 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rpl-22
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT3G05560
7 of 9
Yes
Yes
Atha\AT5G27770
7 of 9
Yes
Yes
Atha\AT1G02830
6 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RPL22A
12 of 15
Yes
Yes
Scer\RPL22B
11 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rpl22
9 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
RpL22-like
7 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RPL22; ribosomal protein L22
    12 of 15
    180474
         
        RPL22L1; ribosomal protein L22 like 1
        9 of 15
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            RpL22 - AGO1
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - AGO2
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - CG14074
            two hybrid
            (Hu et al., 2017.6.13)
            RpL22 - Dredd
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Fukuyama et al., 2012)
            RpL22 - Fmr1
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - Rack1
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL10
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL10Ab
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL11
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL12
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL13
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL13A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL14
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL15
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL17
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL18
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL18A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL19
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL21
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL23
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL23A
            anti bait coimmunoprecipitation, western blot, cosedimentation, Identification by mass spectrometry, electron microscopy
            (Mageeney and Ware, 2019, Anger et al., 2013)
            RpL22 - RpL24
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL26
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL27
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL27A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL28
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL29
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL3
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL30
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL31
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL32
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL34a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL35
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL35A
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL36
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL36A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL37A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL37a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL38
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL39
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL4
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL40
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL41
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL5
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL6
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL7
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL7A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL8
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpL9
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpLP0
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpLP1
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpLP2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS10a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS11
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS12
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS13
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS14a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS14b
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS15
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS15Aa
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS16
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS17
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS18
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS19a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS20
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS21
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS23
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS24
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS25
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS26
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS27
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS27A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS28b
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS29
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS3
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS30
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS3A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS4
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS5a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS6
            cosedimentation, Identification by mass spectrometry, electron microscopy, bimolecular fluorescence complementation, fluorescence microscopy
            (Al-Jubran et al., 2013, Anger et al., 2013)
            RpL22 - RpS7
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS8
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - RpS9
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - Sumo
            anti bait coimmunoprecipitation, anti tag western blot, covalent binding
            (Kearse et al., 2013)
            RpL22 - Ubx
            two hybrid
            (Hsiao et al., 2014)
            RpL22 - eEF2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - jigr1
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            RpL22 - sta
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpL22 - vig
            anti tag coimmunoprecipitation, western blot
            (Zhou et al., 2008)
            RpL22 - vig2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RNA-protein
            Physical Interaction
            Assay
            References
            RpL22 - 18SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 28SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 2SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 5.8SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - 5SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpL22 - hpRNA:CR46342
            anti tag coimmunoprecipitation, northern blot
            (Zhou et al., 2008)
            RpL22 - mir-ban
            anti tag coimmunoprecipitation, northern blot
            (Zhou et al., 2008)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            RpL22
            suppressible
            RpL22-like
            (Mageeney et al., 2018)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            External Data
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map
            1-0
            Cytogenetic map
            1C4-1C4
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            1C4-1C4
            Limits computationally determined from genome sequence between P{EP}sdkEP369 and P{EP}EP1600&P{EP}EP1498
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            1-0

            (FlyBase, 2016)

            1-0.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (6)
            Genomic Clones (7)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (767)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Hopes et al., 2022, Gershman et al., 2020, Kearse et al., 2011)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: RpL22 CG7434

              (Nusskern, 1999.11)
              Source for database merge of
              Additional comments

              "l(1)G0451" may affect "RpL22". "l(1)G0115" may affect "RpL22". "l(1)G0422" may affect "RpL22".

              (Peter et al., 2002)
              Other Comments

              RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

              (Goshima et al., 2007)

              Not a Minute gene.

              (Marygold et al., 2007)

              Deletions removing RpL22 but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

              (Marygold et al., 2007)

              Molecularly-defined mutations in RpL22 do not result in Minute phenotypes.

              (Marygold et al., 2007)

              RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

              (Boutros et al., 2004)

              Identification: Protein that interacts with the AM domain of Parp protein.

              (Koyama et al., 1999)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 48 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (19)
              Reported As
              Symbol Synonym
              CG7434
              (Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Schertel et al., 2013, Chen et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Müller et al., 2010, Zhang et al., 2010, Blagden et al., 2009, Keleman et al., 2009.8.5, Worringer et al., 2009, Goshima et al., 2007, Marygold et al., 2007, Stuart et al., 2007, Cermelli et al., 2006, Shigenobu et al., 2006, Huang et al., 2005, Kai et al., 2005, Huang et al., 2004, Benos, 2000.12.13)
              EG:BACR19J1.4
              (Benos et al., 2001, Benos, 2000.12.13)
              L22
              (Miwa et al., 2020, Ramond et al., 2020, Al-Jubran et al., 2013, Yu and Wolfner, 1998)
              L22e
              (Anger et al., 2013)
              PBP-12
              (Koyama et al., 1999)
              RL22
              (Mushegian et al., 1998)
              RL22_DROME
              (Fukuyama et al., 2012)
              RPL22
              (Norris et al., 2021, Fukuyama et al., 2013, Pinnola et al., 2007)
              Rp L22
              (Alonso and Santaren, 2006)
              RpL22
              (Hopes et al., 2022, Baumgartner et al., 2021, Jin et al., 2020, Parker et al., 2020, Polymenis, 2020, Wang et al., 2020, Hu et al., 2017.6.13, May and Zwaan, 2017, Chlamydas et al., 2016, Angrisani et al., 2015, Dent et al., 2015, Lin et al., 2015, Miettinen and Björklund, 2015, Vedanayagam and Garrigan, 2015, Hsiao et al., 2014, Majzoub et al., 2014, Handler et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Friedman et al., 2011, Kallappagoudar et al., 2010, Müller et al., 2010, Nie et al., 2009, Worringer et al., 2009, Zhou et al., 2008, Goshima et al., 2007, Marygold et al., 2007, Stuart et al., 2007, Beller et al., 2006, Cermelli et al., 2006, Shigenobu et al., 2006, Shigenobu et al., 2006, Otsuki et al., 2004)
              Rpl22
              (Berloco et al., 2021, Hasygar and Hietakangas, 2014, Conrad et al., 2012, Raja et al., 2010, Glover, 1995.12.7)
              anon-EST:Posey53
              eRpL22
              (Gershman et al., 2020, Mageeney and Ware, 2019, Mageeney et al., 2018)
              rpL22
              (Kearse et al., 2011, Karandikar et al., 2003, Zhao et al., 2002)
              rpl22
              (Hallacli et al., 2012, Koyama, 1998.7.24)
              Name Synonyms
              60S RIBOSOMAL PROTEIN L22
              (Hull et al., 2015)
              PARP-binding protein-12
              (Koyama et al., 1999)
              Ribosomal protein L22
              (Fukuyama et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Cho et al., 2005)
              ribosomal protein L22
              (Huang et al., 2004)
              Secondary FlyBase IDs
              • FBgn0025289
              Datasets (8)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (8)
              Result
              Result Type
              Title
              scRNAseq_2020_Cattenoz_NI_seq_clustering
              Clustering analysis of hemocytes from non-infested third instar larvae
              scRNAseq_2020_Cattenoz_WI_seq_clustering
              Clustering analysis of hemocytes from wasp-infested third instar larvae
              scRNAseq_2020_Cho_NI72LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
              scRNAseq_2020_Cho_NI96LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI120LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
              scRNAseq_2020_Cho_WI96LG_seq_clustering
              Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI96HL_seq_clustering
              Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI120HL_seq_clustering
              Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
              References (117)