Gene model reviewed during 5.44
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
950 (aa); 106 (kD predicted)
Interacts with drpr; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shark using the Feature Mapper tool.
Shark protein is first detected at the end of gastrulation in cells destined to form the ectoderm. It is most prominent in the cephalic furrow and along the midline and is limited to the apical surfaces of the epithelia. During germ band extension when the proctodeum first becomes discernable, Shark is expressed apically in its epithelial cells. It is also observed in the cells that are forming the stomodeum. The stomodeum gives rise to the foregut, atrium, pharynx, and oesophagus, all of which express Shark until late embryogenesis. Similarly, the hindgut expressed Shark through its development. Several other ectodermally derived tissues express Shark while they maintain their epithelial character, including the stomatogastric nervous system, the frontal air sac, the tracheal system, gnathal structures, and the salivary glands. In general, Shark is expressed exclusively by ectodermally derived epithelia and is localized preferentially at the apical surface of these cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Shark in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Flies carrying a mutation in shark have a defective dorsal closure phenotype.