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FB2021_04, released August 17, 2021

Gene: Dmel\Shc

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General Information
Symbol
Dmel\Shc
Species
D. melanogaster
Name
SHC-adaptor protein
Annotation Symbol
CG3715
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015296
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dshc

Key Links
Genomic Location
Cytogenetic map
67B5-67B5
Sequence location
3L:9,427,010..9,428,671 [+]
Recombination map
3-29
RefSeq locus
NT_037436 REGION:9427010..9428671
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables epidermal growth factor receptor binding
inferred from direct assay
(Li et al., 1996, Lai et al., 1995)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN000818648
(assigned by GO_Central )
(Gaudet et al., 2011)
enables receptor tyrosine kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN000818658
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (15 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
involved_in border follicle cell migration
inferred from mutant phenotype
(Bianco et al., 2007)
involved_in compound eye photoreceptor cell differentiation
inferred from mutant phenotype
(Luschnig et al., 2000)
involved_in dorsal/ventral axis specification, ovarian follicular epithelium
inferred from mutant phenotype
(Luschnig et al., 2000)
involved_in epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Bianco et al., 2007)
inferred from direct assay
(Li et al., 1996, Lai et al., 1995)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Luschnig et al., 2000)
involved_in epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
involved_in fibroblast growth factor receptor signaling pathway
inferred from mutant phenotype
(Cabernard and Affolter, 2005, Wilson et al., 2005)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Luschnig et al., 2000)
involved_in melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
involved_in mesodermal cell migration
inferred from mutant phenotype
(Wilson et al., 2005)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013)
involved_in regulation of dorsal/ventral axon guidance
inferred from mutant phenotype
(Luschnig et al., 2000)
involved_in torso signaling pathway
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
(Luschnig et al., 2000)
involved_in tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Tran et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000818658
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000818658
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Torso Signaling Pathway Core Components -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
EGFR Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR Signaling Pathway Core Components -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Summary (Interactive Fly)

phosphotyrosine-binding domain protein - interacts with and regulates Torso and Egfr signaling conferring specificity to receptor function

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Shc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Shc-RA
FBtr0076458
NM_079944
1600
409
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Shc-PA
FBpp0076186
45.0
409
6.51
NP_524683
AAF50273
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Shc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Shc
Transgenic constructs containing regulatory region of Shc
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3L)AC1
(Luschnig et al., 2000)
Gene not disrupted in
Df(3L)29A6
(Luschnig et al., 2000)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | embryonic stage | germline clone | maternal effect | recessive
lethal | embryonic stage | maternal effect | recessive
partially lethal - majority die | pupal stage | recessive
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | recessive
male sterile | recessive
Other Phenotypes
Allele
abnormal immune response | larval stage, with Scer\GAL4Hml.PG
abnormal planar polarity | recessive
terminal phenotype | germline clone | maternal effect
visible | recessive
Phenotype manifest in
Allele
border follicle cell | somatic clone
cephalopharyngeal skeleton | germline clone | maternal effect
denticle belt | germline clone | maternal effect
dorsal air sac primordium | somatic clone
dorsal appendage | maternal effect
egg | maternal effect
egg chorion | maternal effect
embryo | extended germ band stage | germline clone | maternal effect
embryo | germline clone | maternal effect
embryonic/first instar larval cuticle | germline clone | maternal effect
embryonic abdominal segment 8 | germline clone | maternal effect
eye
eye | anterior | maternal effect
eye | maternal effect
eye photoreceptor cell | maternal effect
filzkorper | germline clone | maternal effect
Malpighian tubule | germline clone | maternal effect
mesoderm | germline clone
ommatidium
ommatidium | maternal effect
ovary | maternal effect
wing | maternal effect
wing vein L4 | distal | maternal effect
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SHC1
12 of 15
Yes
Yes
1  
Hsap\SHC2
11 of 15
No
Yes
Hsap\SHC3
11 of 15
No
Yes
Hsap\SHC4
10 of 15
No
Yes
Hsap\GULP1
1 of 15
No
No
1  
Hsap\SHD
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Shc1
12 of 15
Yes
Yes
Mmus\Shc2
12 of 15
Yes
Yes
Mmus\Shc3
11 of 15
No
Yes
Mmus\Shc4
9 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Shc1
11 of 13
Yes
Yes
Rnor\Shc2
11 of 13
Yes
Yes
Rnor\Shc3
11 of 13
Yes
Yes
Rnor\Shc4
10 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\shc2
7 of 12
Yes
Yes
Xtro\shc3
7 of 12
Yes
Yes
Xtro\shc4
7 of 12
Yes
Yes
Xtro\shc1
5 of 12
No
Yes
Xtro\shf
1 of 12
No
No
Danio rerio (Zebrafish) (3)
Drer\shc1
12 of 15
Yes
Yes
Drer\shc2
11 of 15
No
Yes
Drer\shc3
7 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\shc-1
12 of 15
Yes
Yes
Cele\C25A8.5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919093V )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003847
Drosophila simulans
Dsim\GD14181
Drosophila sechellia
Dsec\GM25147
Drosophila erecta
Dere\GG15375
Drosophila yakuba
Dyak\GE20839
Drosophila ananassae
Dana\GF24647
Drosophila pseudoobscura pseudoobscura
Dpse\GA17637
Drosophila persimilis
Dper\GL22629
Drosophila willistoni
Dwil\GK17568
Drosophila virilis
Dvir\GJ13345
Drosophila mojavensis
Dmoj\GI12075
Drosophila grimshawi
Dgri\GH15138
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505D6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018870
Glossina morsitans
Tsetse fly
Gmor\GMOY011085
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08399
Mayetiola destructor
Hessian fly
Mdes\Mdes011512
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008739
Anopheles darlingi
American malaria mosquito
Adar\ADAC001548
Anopheles gambiae
Malaria mosquito
Agam\AGAP011463
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006219
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09BV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002678
Danaus plexippus
Monarch butterfly
Dple\DPOGS201490-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015959
Apis florea
Little honeybee
Aflo\4508884452
Apis mellifera
Western honey bee
Amel\LOC412172
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17139
Bombus terrestris
Buff-tailed bumblebee
Bter\15212445
Linepithema humile
Argentine ant
Lhum\LH23355
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000a5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012683
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02472
Tribolium castaneum
Red flour beetle
Tcas\TC010804
Pediculus humanus
Human body louse
Phum\PHUM387540
Rhodnius prolixus
Kissing bug
Rpro\RPRC011028
Cimex lectularius
Bed bug
Clec\CLEC010031
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005468
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05583
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X098F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009841
Ixodes scapularis
Black-legged tick
Isca\ISCW008676
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71165.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g14380
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04DC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020703gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Shc1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Shc1_2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023222
Ciona intestinalis
Vase tunicate
Cint\LOC100181792
Gallus gallus
Domestic chicken
Ggal\SHC3
Gallus gallus
Domestic chicken
Ggal\SHC4
Gallus gallus
Domestic chicken
Ggal\SHC2
Gallus gallus
Domestic chicken
Ggal\SHC1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SHC1; SHC adaptor protein 1
    12 of 15
    600560
         
        SHC2; SHC adaptor protein 2
        11 of 15
        605217
            SHC3; SHC adaptor protein 3
            11 of 15
            605263
                SHC4; SHC adaptor protein 4
                10 of 15
                617372
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    btl::Egfr
                    suppressible
                    Shc
                    (Luschnig et al., 2000)
                    Egfr
                    suppressible
                    Shc
                    (Luschnig et al., 2000)
                    tor
                    suppressible
                    Shc
                    (Luschnig et al., 2000)
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Torso Signaling Pathway Core Components -
                    The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
                    EGFR Signaling Pathway Core Components -
                    The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
                    FGFR Signaling Pathway Core Components -
                    Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
                    Pvr Signaling Pathway Core Components -
                    PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
                    Metabolic Pathways
                    External Data
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3L
                    Recombination map
                    3-29
                    Cytogenetic map
                    67B5-67B5
                    Sequence location
                    3L:9,427,010..9,428,671 [+]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    67B5-67B5
                    Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    67B-67C
                    (Luschnig et al., 2004, Lai, 1995.5.5)
                    67B-67C
                    (determined by in situ hybridisation)
                    (Lai et al., 1995)
                    Experimentally Determined Recombination Data
                    Location

                    3-29

                    (FlyBase, 2016)

                    3-23.0

                    (Comeron et al., 2012)

                    3-

                    (Lai, 1995.5.5)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (7)
                    Genomic Clones (29)
                    cDNA Clones (36)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (Lai et al., 1995)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of

                    Source for merge of: Shc CG3715

                    (Bayraktaroglu, 2000.4.13)
                    Additional comments
                    Other Comments

                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                    (Kiger et al., 2003)

                    Shc is required for signaling by a subset of receptor tyrosine kinases; tor and Egfr, but not sev.

                    (Luschnig et al., 2000)

                    The PTB domain (phosphotyrosine binding domain) possesses a binding specificity for tyrosine-phosphorylated peptides that is optimally suited for recognition of the activated Egfr receptor.

                    (Li et al., 1996)

                    Isolated from a Drosophila cDNA expression library, using an antibody to the human Shc adaptor protein. Immunoprecipitation of protein lysates from flies expressing the activated Egfr::tort4021E.hs.sev receptor indicates that Shc is associated with the Egfr::tort4021E.hs.sev protein in vivo.

                    (Lai et al., 1995)

                    A Shc cDNA has been cloned and sequenced, and its expression pattern has been analysed.

                    (Lai et al., 1995)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 59 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DRscDB
                    EMBL-EBI Single Cell Expression Atlas
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL
                    modMine - A data warehouse for the modENCODE project
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (9)
                    Datasets (0)
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                    Project
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                    References (80)