FB2020_06, released Dec 22, 2020

Gene: Dmel\Ubc2

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General Information
Symbol
Dmel\Ubc2
Species
D. melanogaster
Name
Ubiquitin conjugating enzyme 2
Annotation Symbol
CG6720
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015320
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

UbcD2, l(2)k13206

Key Links
Genomic Location
Cytogenetic map
32A5-32A5
Sequence location
2L:10,765,010..10,768,006 [-]
Recombination map

2-43

RefSeq locus
NT_033779 REGION:10765010..10768006
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables ubiquitin-protein transferase activity
inferred from genetic interaction with SGD:S000000286
(Matuschewski et al., 1996)
inferred from genetic interaction with SGD:S000002466
(Matuschewski et al., 1996)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ubiquitin conjugating enzyme activity
inferred from biological aspect of ancestor with PANTHER:PTN002514495
(assigned by GO_Central )
(Gaudet et al., 2011)
enables ubiquitin-protein transferase activity
inferred from sequence or structural similarity with SGD:S000000286
(Matuschewski et al., 1996)
inferred from sequence or structural similarity with SGD:S000002466
(Matuschewski et al., 1996)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in lipid storage
inferred from direct assay
(Beller et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein polyubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN002514495
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000002466
(FlyBase Curators, 2008--)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002514495
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ubiquitin-conjugating enzyme family. (P52485)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
E2 UBIQUITIN CONJUGATING ENZYMES -
Ubiquitin-conjugating (E2) enzymes accept activated ubiquitin from ubiquitin-activating (E1) enzymes via thioester bond with a conserved catalytic cysteine. E2s then interact with ubiquitin ligases (E3) to directly or indirectly ubiquitinate target proteins. E2s are characterised by a 200 amino acid ubiquitin-conjugating (UBC) domain which interacts with E1 and E3s and acts catalytically. (Adapted from PMID:1994026).
Protein Function (UniProtKB)
Catalyzes the covalent attachment of ubiquitin to other proteins.
(UniProt, P52485)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ubc2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ubc2-RA
FBtr0080115
NM_057789
1558
232
Ubc2-RB
FBtr0080116
NM_164943
1349
232
Ubc2-RC
FBtr0333492
NM_001273433
2111
232
Ubc2-RD
FBtr0345437
NM_001298885
1625
232
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

(Matuschewski et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ubc2-PA
FBpp0079704
24.4
232
8.47
NP_477137
AAF53008
Ubc2-PB
FBpp0079705
24.4
232
8.47
NP_723616
AAN10762
Ubc2-PC
FBpp0305676
24.4
232
8.47
NP_001260362
AGB92897
Ubc2-PD
FBpp0311562
24.4
232
8.47
NP_001285814
AHN54328
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

232 aa isoforms: Ubc2-PA, Ubc2-PB, Ubc2-PC, Ubc2-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

232 (aa); 24.5 (kD predicted)

(Matuschewski et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubc2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ubc2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ubc2
Transgenic constructs containing regulatory region of Ubc2
Deletions and Duplications ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\UBE2E2
13 of 15
Yes
Yes
Hsap\UBE2E3
13 of 15
Yes
Yes
1  
Hsap\UBE2E1
12 of 15
No
Yes
Hsap\UBE2D1
2 of 15
No
No
Hsap\UBE2D2
2 of 15
No
No
1  
Hsap\UBE2D3
2 of 15
No
No
Hsap\UBE2D4
2 of 15
No
No
1  
Hsap\BIRC6
1 of 15
No
No
Hsap\CDC34
1 of 15
No
No
1  
Hsap\UBE2A
1 of 15
No
No
Hsap\UBE2B
1 of 15
No
No
1  
Hsap\UBE2C
1 of 15
No
No
Hsap\UBE2E4P
1 of 15
No
Yes
Hsap\UBE2G1
1 of 15
No
No
Hsap\UBE2I
1 of 15
No
No
Hsap\UBE2J1
1 of 15
No
Yes
Hsap\UBE2K
1 of 15
No
No
Hsap\UBE2L3
1 of 15
No
No
1  
Hsap\UBE2L6
1 of 15
No
No
Hsap\UBE2N
1 of 15
No
No
Hsap\UBE2O
1 of 15
No
No
Hsap\UBE2R2
1 of 15
No
No
1  
Hsap\UBE2S
1 of 15
No
No
Hsap\UBE2T
1 of 15
No
Yes
Hsap\UBE2U
1 of 15
No
Yes
Hsap\UBE2W
1 of 15
No
No
Hsap\UBE2Z
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (28)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ube2e2
13 of 15
Yes
Yes
Mmus\Ube2e3
12 of 15
No
Yes
Mmus\Ube2e1
11 of 15
No
Yes
Mmus\Ube2d2b
3 of 15
No
No
Mmus\Ube2dnl1
3 of 15
No
No
Mmus\Ube2dnl2
3 of 15
No
No
Mmus\Ube2d1
2 of 15
No
No
Mmus\Ube2d2a
2 of 15
No
No
Mmus\Ube2d3
2 of 15
No
No
Mmus\Birc6
1 of 15
No
No
Mmus\Cdc34
1 of 15
No
No
Mmus\Ube2a
1 of 15
No
No
Mmus\Ube2b
1 of 15
No
No
Mmus\Ube2c
1 of 15
No
No
Mmus\Ube2g1
1 of 15
No
No
Mmus\Ube2i
1 of 15
No
No
Mmus\Ube2j1
1 of 15
No
Yes
Mmus\Ube2k
1 of 15
No
No
Mmus\Ube2l3
1 of 15
No
No
Mmus\Ube2l6
1 of 15
No
No
Mmus\Ube2n
1 of 15
No
No
Mmus\Ube2o
1 of 15
No
No
Mmus\Ube2r2
1 of 15
No
No
Mmus\Ube2s
1 of 15
No
No
Mmus\Ube2t
1 of 15
No
Yes
Mmus\Ube2u
1 of 15
No
No
Mmus\Ube2w
1 of 15
No
No
Mmus\Ube2z
1 of 15
No
No
Rattus norvegicus (Norway rat) (23)
Rnor\Ube2e1
7 of 13
Yes
Yes
Rnor\Ube2e3
7 of 13
Yes
Yes
Rnor\Ube2e2
4 of 13
No
Yes
Rnor\Ube2d4
3 of 13
No
No
Rnor\Ube2d1
2 of 13
No
No
Rnor\Ube2d3
2 of 13
No
No
Rnor\Birc6
1 of 13
No
No
Rnor\Ube2a
1 of 13
No
No
Rnor\Ube2b
1 of 13
No
No
Rnor\Ube2c
1 of 13
No
No
Rnor\Ube2d2
1 of 13
No
No
Rnor\Ube2g1
1 of 13
No
No
Rnor\Ube2i
1 of 13
No
No
Rnor\Ube2j1
1 of 13
No
Yes
Rnor\Ube2k
1 of 13
No
No
Rnor\Ube2l3
1 of 13
No
No
Rnor\Ube2l6
1 of 13
No
No
Rnor\Ube2o
1 of 13
No
No
Rnor\Ube2r2
1 of 13
No
No
Rnor\Ube2s
1 of 13
No
No
Rnor\Ube2t
1 of 13
No
Yes
Rnor\Ube2u
1 of 13
No
Yes
Rnor\Ube2z
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\ube2e3
10 of 12
Yes
Yes
Xtro\ube2e1
7 of 12
No
Yes
Xtro\ube2e2
6 of 12
No
Yes
Xtro\ube2d1
2 of 12
No
No
Xtro\ube2d3
2 of 12
No
No
Xtro\ube2d4
2 of 12
No
No
Xtro\birc6
1 of 12
No
No
Xtro\cdc34
1 of 12
No
No
Xtro\ube2a
1 of 12
No
No
Xtro\ube2b
1 of 12
No
No
Xtro\ube2c
1 of 12
No
No
Xtro\ube2g1
1 of 12
No
No
Xtro\ube2i
1 of 12
No
No
Xtro\ube2j1
1 of 12
No
Yes
Xtro\ube2k
1 of 12
No
No
Xtro\ube2l3
1 of 12
No
No
Xtro\ube2n
1 of 12
No
No
Xtro\ube2r2
1 of 12
No
No
Xtro\ube2s
1 of 12
No
No
Xtro\ube2w
1 of 12
No
No
Xtro\ube2z
1 of 12
No
No
Danio rerio (Zebrafish) (33)
Drer\ube2e2
13 of 15
Yes
Yes
Drer\ube2e3
12 of 15
No
Yes
Drer\ube2e1
7 of 15
No
Yes
Drer\ube2d1a
2 of 15
No
No
Drer\ube2d1b
2 of 15
No
No
Drer\ube2d2
2 of 15
No
No
Drer\ube2d3
2 of 15
No
No
Drer\ube2d4
2 of 15
No
No
Drer\birc6
1 of 15
No
No
Drer\cdc34b
1 of 15
No
No
Drer\dnttip1
1 of 15
No
No
Drer\flj11011l
1 of 15
No
No
Drer\ube2a
1 of 15
No
No
Drer\ube2al
1 of 15
No
No
Drer\ube2b
1 of 15
No
No
Drer\ube2d2l
1 of 15
No
No
Drer\ube2g1a
1 of 15
No
No
Drer\ube2g1b
1 of 15
No
No
Drer\ube2ia
1 of 15
No
No
Drer\ube2ib
1 of 15
No
No
Drer\ube2j1
1 of 15
No
Yes
Drer\ube2ka
1 of 15
No
No
Drer\ube2kb
1 of 15
No
No
Drer\ube2l3a
1 of 15
No
No
Drer\ube2l3b
1 of 15
No
No
Drer\ube2na
1 of 15
No
No
Drer\ube2nb
1 of 15
No
No
Drer\ube2o
1 of 15
No
No
Drer\ube2r2
1 of 15
No
No
Drer\ube2s
1 of 15
No
No
Drer\ube2t
1 of 15
No
Yes
Drer\ube2w
1 of 15
No
No
Drer\ube2z
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (17)
Cele\C28G1.10
2 of 15
Yes
Yes
Cele\let-70
2 of 15
Yes
No
Cele\ubc-24
2 of 15
Yes
Yes
Cele\ubc-1
1 of 15
No
No
Cele\ubc-6
1 of 15
No
Yes
Cele\ubc-7
1 of 15
No
No
Cele\ubc-9
1 of 15
No
No
Cele\ubc-13
1 of 15
No
No
Cele\ubc-16
1 of 15
No
No
Cele\ubc-17
1 of 15
No
No
Cele\ubc-18
1 of 15
No
No
Cele\ubc-20
1 of 15
No
No
Cele\ubc-21
1 of 15
No
No
Cele\ubc-22
1 of 15
No
No
Cele\ubc-23
1 of 15
No
No
Cele\uev-2
1 of 15
No
No
Cele\uev-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\FUS9
5 of 9
Yes
Yes
Atha\UBC8
1 of 9
No
No
Atha\UBC9
1 of 9
No
No
Atha\UBC10
1 of 9
No
No
Atha\UBC11
1 of 9
No
No
Atha\UBC12
1 of 9
No
No
Atha\UBC28
1 of 9
No
No
Atha\UBC29
1 of 9
No
No
Atha\UBC30
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\CDC34
1 of 15
Yes
No
1  
Scer\PEX4
1 of 15
Yes
No
Scer\RAD6
1 of 15
Yes
No
Scer\UBC1
1 of 15
Yes
No
Scer\UBC4
1 of 15
Yes
No
Scer\UBC5
1 of 15
Yes
No
Scer\UBC9
1 of 15
Yes
No
Scer\UBC11
1 of 15
Yes
No
Scer\UBC13
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ubc14
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GCJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001851
Drosophila simulans
Dsim\GD22227
Drosophila sechellia
Dsec\GM11457
Drosophila erecta
Dere\GG10359
Drosophila yakuba
Dyak\GE13339
Drosophila ananassae
Dana\GF14068
Drosophila pseudoobscura pseudoobscura
Dpse\GA19810
Drosophila persimilis
Dper\GL26387
Drosophila willistoni
Dwil\GK23983
Drosophila virilis
Dvir\GJ17643
Drosophila mojavensis
Dmoj\GI17815
Drosophila grimshawi
Dgri\GH13340
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DYF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024127
Glossina morsitans
Tsetse fly
Gmor\GMOY008734
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07626
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005038
Anopheles darlingi
American malaria mosquito
Adar\ADAC009100
Anopheles gambiae
Malaria mosquito
Agam\AGAP007952
Anopheles gambiae
Malaria mosquito
Agam\AGAP012754
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001502
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0IP9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010541
Bombyx mori
Silkmoth
Bmor\BGIBMGA002918
Danaus plexippus
Monarch butterfly
Dple\DPOGS200166-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200498-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005107
Heliconius melpomene
Postman butterfly
Hmel\HMEL006881
Apis florea
Little honeybee
Aflo\2368864788
Apis florea
Little honeybee
Aflo\3369110196
Apis mellifera
Western honey bee
Amel\LOC724793
Apis mellifera
Western honey bee
Amel\UbcD2
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10401
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15298
Bombus terrestris
Buff-tailed bumblebee
Bter\15208574
Bombus terrestris
Buff-tailed bumblebee
Bter\15215993
Linepithema humile
Argentine ant
Lhum\LH13622
Linepithema humile
Argentine ant
Lhum\LH22371
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00160a
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00190e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007707
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010264
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01946
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02422
Tribolium castaneum
Red flour beetle
Tcas\eff
Tribolium castaneum
Red flour beetle
Tcas\TC012100
Pediculus humanus
Human body louse
Phum\PHUM437950
Pediculus humanus
Human body louse
Phum\PHUM570280
Rhodnius prolixus
Kissing bug
Rpro\RPRC005317
Rhodnius prolixus
Kissing bug
Rpro\RPRC012234
Cimex lectularius
Bed bug
Clec\CLEC001726
Cimex lectularius
Bed bug
Clec\CLEC006604
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003002
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000078
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08928
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11733
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DVW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008921
Ixodes scapularis
Black-legged tick
Isca\ISCW018551
Ixodes scapularis
Black-legged tick
Isca\ISCW020158
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60987.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77107.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur348g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g03260
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02420
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_120690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_230542
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GF8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ube2e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_008618gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006199gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009521gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ubc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ube1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027607gn
Ciona intestinalis
Vase tunicate
Cint\LOC100183458
Ciona intestinalis
Vase tunicate
Cint\LOC100185831
Ciona intestinalis
Vase tunicate
Cint\LOC104266887
Ciona intestinalis
Vase tunicate
Cint\LOC100175624
Ciona intestinalis
Vase tunicate
Cint\LOC100185453
Gallus gallus
Domestic chicken
Ggal\UBE2E1
Gallus gallus
Domestic chicken
Ggal\UBE2D1
Gallus gallus
Domestic chicken
Ggal\UBE2E3
Gallus gallus
Domestic chicken
Ggal\UBE2D3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (28)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG2574
5 of 10
CG5440
5 of 10
eff
4 of 10
CG10862
3 of 10
CG17030
3 of 10
Ubc10
3 of 10
Ubc84D
3 of 10
ben
2 of 10
CG2924
2 of 10
CG3473
2 of 10
CG4502
2 of 10
CG7220
2 of 10
CG8188
2 of 10
CG10254
2 of 10
morgue
2 of 10
Ubc4
2 of 10
vih
2 of 10
Bruce
1 of 10
CG5823
1 of 10
CG7656
1 of 10
CG14739
1 of 10
CG40045
1 of 10
lwr
1 of 10
Ubc6
1 of 10
Ubc87F
1 of 10
UbcE2H
1 of 10
UbcE2M
1 of 10
Uev1A
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    UBE2E2; ubiquitin conjugating enzyme E2 E2
    13 of 15
    602163
        UBE2E3; ubiquitin conjugating enzyme E2 E3
        13 of 15
        604151
             
            UBE2E1; ubiquitin conjugating enzyme E2 E1
            12 of 15
            602916
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Ubc2 - CG44251
                two hybrid
                (Hu et al., 2017.6.13)
                Ubc2 - Iru
                two hybrid
                (Hu et al., 2017.6.13)
                Ubc2 - Su(dx)
                two hybrid
                (Hu et al., 2017.6.13)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                enc
                enhanceable
                Ubc2
                (Ohlmeyer and Schupbach, 2003)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map

                2-43

                Cytogenetic map
                32A5-32A5
                Sequence location
                2L:10,765,010..10,768,006 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                32A5-32A5
                Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                32A-32A
                (determined by in situ hybridisation)
                (Abdelilah-Seyfried et al., 2000)
                32A4-32A5
                (determined by in situ hybridisation)
                (Spradling et al., 1999)
                32A-32B
                (determined by in situ hybridisation)
                (Matuschewski et al., 1996)
                32A4-32A5
                (BDGP Project Members, 1994-1999)
                Experimentally Determined Recombination Data
                Location

                2-43

                (FlyBase, 2016)

                2-36.5

                (Comeron et al., 2012)

                2-

                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (4)
                Genomic Clones (33)
                cDNA Clones (134)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Ubc2 UbcD2

                  (FlyBase, 2009-)
                  Source for database merge of

                  Source for merge of: UbcD2 l(2)k13206

                  (Spradling et al., 1999)
                  Additional comments

                  Renamed from 'UbcD2' to 'Ubc2' as the 'D' indicates 'Drosophila' (which FlyBase nomenclature rules disallow) and to avoid the implication that this is the specific ortholog of human UBE2D2.

                  (FlyBase, 2009-)
                  Other Comments

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  A UbcD2 cDNA has been cloned and sequenced.

                  (Matuschewski et al., 1996)

                  S.cerevisiae Scer\ubc4 Scer\ubc5 double mutants are partially functionally complemented by UbcD2.

                  (Matuschewski et al., 1996)
                  Origin and Etymology
                  Discoverer
                  Etymology

                  Named 'UbcD2' for 'ubiquitin-conjugating enzyme from Drosophila 2 (the numbering reflects the order of identification).

                  (Matuschewski et al., 1996)
                  Identification
                  External Crossreferences and Linkouts ( 68 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  ApoDroso - Functional genomic database for photoreceptor development, survival and function
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (8)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (68)