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Gene Dmel\Vha26

General Information
Symbol	Dmel\Vha26	Species	D. melanogaster
Name	Vacuolar H+-ATPase 26kD E subunit	Annotation symbol	CG1088
Feature type	protein_coding_gene	FlyBase ID	FBgn0015324
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	83B4-83B4	Sequence location	3R:1,417,453..1,420,429 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Vacuolar H+-ATPase 26kD E subunit is referred to in FlyBase by the symbol Dmel\Vha26 (CG1088, FBgn0015324). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: hydrogen-exporting ATPase activity, phosphorylative mechanism. It is reported to be involved in the biological process: proton transport. 6 alleles are reported. The phenotype of these alleles is annotated with: Malpighian tubule. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ATPase, V1/A1 complex, subunit E. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629065_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Vha26. Gene sequence location is 3R:1417453..1420429.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Adamson et al., 2011, Genetics 189(2): 495--506 Sequence features HFA12371 BKN29326
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B4-83B4   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84A-84B     (Guo, 1995.10.19) 83B-83B     (Dow, 1999) 83B-83B     (Dow et al., 1997) 83B1-83B4   (determined by in situ hybridisation)   (Guo et al., 1996)
Experimentally Determined Recombination Data
Location	3- (Guo, 1995.10.19)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Vha26 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Vha26-RA FBtr0078701  NM_169073   2276   226 Vha26-RB FBtr0078700  NM_079513   2211   226
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Vha26-PA   FBpp0078350   26.1   226   5.96     NP_730957   AAF51998 Vha26-PB   FBpp0078349   26.1   226   5.96     NP_524237   AAF51997
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, V1/A1 complex, subunit E (IPR002842)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202988   AA263315   AA264379   AA264604   AA438311   AA439084   AA439557   AA441110   AA540651   AA541206   AA696391   AA802803   AA802982   AA816961   AA979249   AE014297 AAF51997   AE014297 AAF51998   AF145618 AAD38593   AI061768   AI063272   AI063718   AI063736   AI064579   AI107833   AI110061   AI110073   AI238601   AI239182   AI296422   AI297561   AI386756   AI401922   AI515394   AI517700   AI531450   AI532174   AI534423   AI534573   AI543297   AI544205   AI944414   BG631969   BG634787   BG636196   BG637098   BG638057   BG640260   BG640402   BI161777   BI161778   BI162076   BI162077   BI162458   BI162459   BI162923   BI163011   BI164440   BI164885   BI165454   BI166763   BI168438   BI169198   BI170025   BI170347   BI170499   BI171282   BI172032   BI172289   BI173250   BI173740   BI173827   BI213157   BI213766   BI215357   BI227974   BI228615   BI228835   BI228843   BI229724   BI229839   BI230623   BI232381   BI233045   BI233271   BI234745   BI235008   BI236718   BI237467   BI237482   BI239387   BI239488   BI239668   BI240136   BI240720   BI243294   BI356608   BI357680   BI357711   BI358195   BI362458   BI362480   BI363432   BI365663   BI366641   BI366824   BI370573   BI370644   BI370828   BI370866   BI370967   BI371375   BI371460   BI371591   BI372632   BI373565   BI374128   BI375976   BI482457   BI484479   BI485524   BI485944   BI486244   BI486725   BI574174   BI574828   BI575225   BI578256   BI578473   BI581942   BI582172   BI585925   BI593345   BI604783   BI605686   BI606219   BI607163   BI608946   BI612503   BI612695   BI614904   BI618570   BI618667   BI618676   BI620005   BI620530   BI620565   BI620668   BI621013   BI621073   BI621098   BI621453   BI621958   BI622842   BI625523   BI626758   BI628270   BI628819   BI631025   BI631120   BI631491   BP541464   BP541891   BP552513   CK657962   CK659453   CK659782   CK661271   CK662010   CO180386   CO181401   CO184663   CO266111   CO269409   CO290513   CO294239   CO300772   CO303855   CO304552   CO305187   CO309807   CO312953   CO312988   CO317138   CO317804   CO323448   CO329850   CO333204   CO342780   DQ440358   DQ443323   EC058891   EC061508   EC068880   EC068945   EC073935   EC076337   EC076743   EC088706   EC197497   EC197978   EC201991   EC204185   EC212981   EC220093   EC227831   EC248428   EC249392   EV599412   FE863457   FE863478   FE863551   FE863608   FE863865   GH763076   GH766341   GH767374   GH767375   GH941514   GH941761   GH947086   GH947228   GH948259   GH948400   GH952225   GH952763   GH957574   GH957653   GH959577   GH964629   GH970596   GH971942   GH971978   GH972336   GH973793   GH977380   GH979096   GH983378   U38198 AAB09738   U38951 AAB09739
UniProtKB/Swiss-Prot	P54611
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015324    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015324 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015324 expression level Developmental Stage   Expression Level embryo 00-02hr    13042 embryo 02-04hr    14137 embryo 04-06hr    8078 embryo 06-08hr    6100 embryo 08-10hr    9213 embryo 10-12hr    8584 embryo 12-14hr    11310 embryo 14-16hr    12301 embryo 16-18hr    21059 embryo 18-20hr    25415 embryo 20-22hr    41870 embryo 22-24hr    52992 larva L1    43170 larva L2    38203 larva L3 12hr old    29082 larva L3 puffstage 1-2    17263 larva L3 puffstage 3-6    14618 larva L3 puffstage 7-9    14503 white prepupae new    10865 white prepupae 12hr    13832 white prepupae 24hr    7914 pupae 2d postWPP    10801 pupae 3d postWPP    13636 pupae 4d postWPP    18713 adult male 01day    20244 adult male 05day    16473 adult male 30day    14718 adult female 01day    18524 adult female 05day    18610 adult female 30day    16358 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13042) embryo 02-04hr  (14137) embryo 04-06hr  (8078) embryo 06-08hr  (6100) embryo 08-10hr  (9213) embryo 10-12hr  (8584) embryo 12-14hr  (11310) embryo 14-16hr  (12301) embryo 16-18hr  (21059) embryo 18-20hr  (25415) embryo 20-22hr  (41870) embryo 22-24hr  (52992) larva L1  (43170) larva L2  (38203) larva L3 12hr old  (29082) larva L3 puffstage 1-2  (17263) larva L3 puffstage 3-6  (14618) larva L3 puffstage 7-9  (14503) white prepupae new  (10865) white prepupae 12hr  (13832) white prepupae 24hr  (7914) pupae 2d postWPP  (10801) pupae 3d postWPP  (13636) pupae 4d postWPP  (18713) adult male 01day  (20244) adult male 05day  (16473) adult male 30day  (14718) adult female 01day  (18524) adult female 05day  (18610) adult female 30day  (16358) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13042) embryo 02-04hr  (14137) embryo 04-06hr  (8078) embryo 06-08hr  (6100) embryo 08-10hr  (9213) embryo 10-12hr  (8584) embryo 12-14hr  (11310) embryo 14-16hr  (12301) embryo 16-18hr  (21059) embryo 18-20hr  (25415) embryo 20-22hr  (41870) embryo 22-24hr  (52992) larva L1  (43170) larva L2  (38203) larva L3 12hr old  (29082) larva L3 puffstage 1-2  (17263) larva L3 puffstage 3-6  (14618) larva L3 puffstage 7-9  (14503) white prepupae new  (10865) white prepupae 12hr  (13832) white prepupae 24hr  (7914) pupae 2d postWPP  (10801) pupae 3d postWPP  (13636) pupae 4d postWPP  (18713) adult male 01day  (20244) adult male 05day  (16473) adult male 30day  (14718) adult female 01day  (18524) adult female 05day  (18610) adult female 30day  (16358) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (13042) embryo 02-04hr  (14137) embryo 04-06hr    8078 embryo 06-08hr    6100 embryo 08-10hr    9213 embryo 10-12hr    8584 embryo 12-14hr  (11310) embryo 14-16hr  (12301) embryo 16-18hr  (21059) embryo 18-20hr  (25415) embryo 20-22hr  (41870) embryo 22-24hr  (52992) larva L1  (43170) larva L2  (38203) larva L3 12hr old  (29082) larva L3 puffstage 1-2  (17263) larva L3 puffstage 3-6  (14618) larva L3 puffstage 7-9  (14503) white prepupae new  (10865) white prepupae 12hr  (13832) white prepupae 24hr    7914 pupae 2d postWPP  (10801) pupae 3d postWPP  (13636) pupae 4d postWPP  (18713) adult male 01day  (20244) adult male 05day  (16473) adult male 30day  (14718) adult female 01day  (18524) adult female 05day  (18610) adult female 30day  (16358) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13042 embryo 02-04hr    14137 embryo 04-06hr    8078 embryo 06-08hr    6100 embryo 08-10hr    9213 embryo 10-12hr    8584 embryo 12-14hr    11310 embryo 14-16hr    12301 embryo 16-18hr    21059 embryo 18-20hr    25415 embryo 20-22hr    41870 embryo 22-24hr    52992 larva L1    43170 larva L2    38203 larva L3 12hr old    29082 larva L3 puffstage 1-2    17263 larva L3 puffstage 3-6    14618 larva L3 puffstage 7-9    14503 white prepupae new    10865 white prepupae 12hr    13832 white prepupae 24hr    7914 pupae 2d postWPP    10801 pupae 3d postWPP    13636 pupae 4d postWPP    18713 adult male 01day    20244 adult male 05day    16473 adult male 30day    14718 adult female 01day    18524 adult female 05day    18610 adult female 30day    16358 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015324 expression level Developmental Stage   Expression Level embryo 00-02hr    13042 embryo 02-04hr    14137 embryo 04-06hr    8078 embryo 06-08hr    6100 embryo 08-10hr    9213 embryo 10-12hr    8584 embryo 12-14hr    11310 embryo 14-16hr    12301 embryo 16-18hr    21059 embryo 18-20hr    25415 embryo 20-22hr    41870 embryo 22-24hr    52992 larva L1    43170 larva L2    38203 larva L3 12hr old    29082 larva L3 puffstage 1-2    17263 larva L3 puffstage 3-6    14618 larva L3 puffstage 7-9    14503 white prepupae new    10865 white prepupae 12hr    13832 white prepupae 24hr    7914 pupae 2d postWPP    10801 pupae 3d postWPP    13636 pupae 4d postWPP    18713 adult male 01day    20244 adult male 05day    16473 adult male 30day    14718 adult female 01day    18524 adult female 05day    18610 adult female 30day    16358 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13042) embryo 02-04hr  (14137) embryo 04-06hr  (8078) embryo 06-08hr  (6100) embryo 08-10hr  (9213) embryo 10-12hr  (8584) embryo 12-14hr  (11310) embryo 14-16hr  (12301) embryo 16-18hr  (21059) embryo 18-20hr  (25415) embryo 20-22hr  (41870) embryo 22-24hr  (52992) larva L1  (43170) larva L2  (38203) larva L3 12hr old  (29082) larva L3 puffstage 1-2  (17263) larva L3 puffstage 3-6  (14618) larva L3 puffstage 7-9  (14503) white prepupae new  (10865) white prepupae 12hr  (13832) white prepupae 24hr  (7914) pupae 2d postWPP  (10801) pupae 3d postWPP  (13636) pupae 4d postWPP  (18713) adult male 01day  (20244) adult male 05day  (16473) adult male 30day  (14718) adult female 01day  (18524) adult female 05day  (18610) adult female 30day  (16358) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13042) embryo 02-04hr  (14137) embryo 04-06hr  (8078) embryo 06-08hr  (6100) embryo 08-10hr  (9213) embryo 10-12hr  (8584) embryo 12-14hr  (11310) embryo 14-16hr  (12301) embryo 16-18hr  (21059) embryo 18-20hr  (25415) embryo 20-22hr  (41870) embryo 22-24hr  (52992) larva L1  (43170) larva L2  (38203) larva L3 12hr old  (29082) larva L3 puffstage 1-2  (17263) larva L3 puffstage 3-6  (14618) larva L3 puffstage 7-9  (14503) white prepupae new  (10865) white prepupae 12hr  (13832) white prepupae 24hr  (7914) pupae 2d postWPP  (10801) pupae 3d postWPP  (13636) pupae 4d postWPP  (18713) adult male 01day  (20244) adult male 05day  (16473) adult male 30day  (14718) adult female 01day  (18524) adult female 05day  (18610) adult female 30day  (16358) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  13042 embryo 02-04hr  14137 embryo 04-06hr    8078 embryo 06-08hr    6100 embryo 08-10hr    9213 embryo 10-12hr    8584 embryo 12-14hr  11310 embryo 14-16hr  12301 embryo 16-18hr  (21059) embryo 18-20hr  (25415) embryo 20-22hr  (41870) embryo 22-24hr  (52992) larva L1  (43170) larva L2  (38203) larva L3 12hr old  (29082) larva L3 puffstage 1-2  17263 larva L3 puffstage 3-6  14618 larva L3 puffstage 7-9  14503 white prepupae new  10865 white prepupae 12hr  13832 white prepupae 24hr    7914 pupae 2d postWPP  10801 pupae 3d postWPP  13636 pupae 4d postWPP  18713 adult male 01day  20244 adult male 05day  16473 adult male 30day  14718 adult female 01day  18524 adult female 05day  18610 adult female 30day  16358 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13042 embryo 02-04hr    14137 embryo 04-06hr    8078 embryo 06-08hr    6100 embryo 08-10hr    9213 embryo 10-12hr    8584 embryo 12-14hr    11310 embryo 14-16hr    12301 embryo 16-18hr    21059 embryo 18-20hr    25415 embryo 20-22hr    41870 embryo 22-24hr    52992 larva L1    43170 larva L2    38203 larva L3 12hr old    29082 larva L3 puffstage 1-2    17263 larva L3 puffstage 3-6    14618 larva L3 puffstage 7-9    14503 white prepupae new    10865 white prepupae 12hr    13832 white prepupae 24hr    7914 pupae 2d postWPP    10801 pupae 3d postWPP    13636 pupae 4d postWPP    18713 adult male 01day    20244 adult male 05day    16473 adult male 30day    14718 adult female 01day    18524 adult female 05day    18610 adult female 30day    16358 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015324    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015324 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015324 expression level Tissue   Expression Level Larval Central Nervous System    1587.925 Larval Midgut    4646.5 Larval Hindgut    5110.6 Larval Malpighian Tubules    3979.8 Larval Fat Body    1624.6 Larval Salivary Gland    3937.6 Larval Trachea    2608.475 Larval Carcass    2754.05 Adult Head    2099.5 Adult Eye    1648.475 Adult Brain    2409.8 Adult Thoracic-Abdominal Ganglion    2972.3 Adult Crop    2093.2 Adult Midgut    4330.8 Adult Hindgut    5075 Adult Malpighian Tubules    6448.4 Adult Fat Body    1276.9 Adult Salivary Gland    11317 Adult Heart    1734.975 Adult VirginFemale Spermatheca    1569.4 Adult InseminatedFemale Spermatheca    1706.6 Adult Ovary    1498.5 Adult Testis    777.3 Adult Male Accessory Gland    1730.4 Adult Carcass    1771.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1587.925) Larval Midgut  (4646.5) Larval Hindgut  (5110.6) Larval Malpighian Tubules  (3979.8) Larval Fat Body  (1624.6) Larval Salivary Gland  (3937.6) Larval Trachea  (2608.475) Larval Carcass  (2754.05) Adult Head  (2099.5) Adult Eye  (1648.475) Adult Brain  (2409.8) Adult Thoracic-Abdominal Ganglion  (2972.3) Adult Crop  (2093.2) Adult Midgut  (4330.8) Adult Hindgut  (5075) Adult Malpighian Tubules  (6448.4) Adult Fat Body  (1276.9) Adult Salivary Gland  (11317) Adult Heart  (1734.975) Adult VirginFemale Spermatheca  (1569.4) Adult InseminatedFemale Spermatheca  (1706.6) Adult Ovary  (1498.5) Adult Testis  (777.3) Adult Male Accessory Gland  (1730.4) Adult Carcass  (1771.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1587.925) Larval Midgut  (4646.5) Larval Hindgut  (5110.6) Larval Malpighian Tubules  (3979.8) Larval Fat Body  (1624.6) Larval Salivary Gland  (3937.6) Larval Trachea  (2608.475) Larval Carcass  (2754.05) Adult Head  (2099.5) Adult Eye  (1648.475) Adult Brain  (2409.8) Adult Thoracic-Abdominal Ganglion  (2972.3) Adult Crop  (2093.2) Adult Midgut  (4330.8) Adult Hindgut  (5075) Adult Malpighian Tubules  (6448.4) Adult Fat Body  (1276.9) Adult Salivary Gland  (11317) Adult Heart  (1734.975) Adult VirginFemale Spermatheca  (1569.4) Adult InseminatedFemale Spermatheca  (1706.6) Adult Ovary  (1498.5) Adult Testis    777.3 Adult Male Accessory Gland  (1730.4) Adult Carcass  (1771.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1587.925 Larval Midgut    4646.5 Larval Hindgut    5110.6 Larval Malpighian Tubules    3979.8 Larval Fat Body    1624.6 Larval Salivary Gland    3937.6 Larval Trachea    2608.475 Larval Carcass    2754.05 Adult Head    2099.5 Adult Eye    1648.475 Adult Brain    2409.8 Adult Thoracic-Abdominal Ganglion    2972.3 Adult Crop    2093.2 Adult Midgut    4330.8 Adult Hindgut    5075 Adult Malpighian Tubules    6448.4 Adult Fat Body    1276.9 Adult Salivary Gland    11317 Adult Heart    1734.975 Adult VirginFemale Spermatheca    1569.4 Adult InseminatedFemale Spermatheca    1706.6 Adult Ovary    1498.5 Adult Testis    777.3 Adult Male Accessory Gland    1730.4 Adult Carcass    1771.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015324 expression level Tissue   Expression Level Larval Central Nervous System    1587.925 Larval Midgut    4646.5 Larval Hindgut    5110.6 Larval Malpighian Tubules    3979.8 Larval Fat Body    1624.6 Larval Salivary Gland    3937.6 Larval Trachea    2608.475 Larval Carcass    2754.05 Adult Head    2099.5 Adult Eye    1648.475 Adult Brain    2409.8 Adult Thoracic-Abdominal Ganglion    2972.3 Adult Crop    2093.2 Adult Midgut    4330.8 Adult Hindgut    5075 Adult Malpighian Tubules    6448.4 Adult Fat Body    1276.9 Adult Salivary Gland    11317 Adult Heart    1734.975 Adult VirginFemale Spermatheca    1569.4 Adult InseminatedFemale Spermatheca    1706.6 Adult Ovary    1498.5 Adult Testis    777.3 Adult Male Accessory Gland    1730.4 Adult Carcass    1771.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1587.925) Larval Midgut  (4646.5) Larval Hindgut  (5110.6) Larval Malpighian Tubules  (3979.8) Larval Fat Body  (1624.6) Larval Salivary Gland  (3937.6) Larval Trachea  (2608.475) Larval Carcass  (2754.05) Adult Head  (2099.5) Adult Eye  (1648.475) Adult Brain  (2409.8) Adult Thoracic-Abdominal Ganglion  (2972.3) Adult Crop  (2093.2) Adult Midgut  (4330.8) Adult Hindgut  (5075) Adult Malpighian Tubules  (6448.4) Adult Fat Body  (1276.9) Adult Salivary Gland  (11317) Adult Heart  (1734.975) Adult VirginFemale Spermatheca  (1569.4) Adult InseminatedFemale Spermatheca  (1706.6) Adult Ovary  (1498.5) Adult Testis  777.3 Adult Male Accessory Gland  (1730.4) Adult Carcass  (1771.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1587.925 Larval Midgut  (4646.5) Larval Hindgut  (5110.6) Larval Malpighian Tubules  (3979.8) Larval Fat Body  1624.6 Larval Salivary Gland  (3937.6) Larval Trachea  (2608.475) Larval Carcass  (2754.05) Adult Head  (2099.5) Adult Eye  1648.475 Adult Brain  (2409.8) Adult Thoracic-Abdominal Ganglion  (2972.3) Adult Crop  (2093.2) Adult Midgut  (4330.8) Adult Hindgut  (5075) Adult Malpighian Tubules  (6448.4) Adult Fat Body  1276.9 Adult Salivary Gland  (11317) Adult Heart  (1734.975) Adult VirginFemale Spermatheca  1569.4 Adult InseminatedFemale Spermatheca  1706.6 Adult Ovary  1498.5 Adult Testis    777.3 Adult Male Accessory Gland  (1730.4) Adult Carcass  (1771.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1587.925 Larval Midgut    4646.5 Larval Hindgut    5110.6 Larval Malpighian Tubules    3979.8 Larval Fat Body    1624.6 Larval Salivary Gland    3937.6 Larval Trachea    2608.475 Larval Carcass    2754.05 Adult Head    2099.5 Adult Eye    1648.475 Adult Brain    2409.8 Adult Thoracic-Abdominal Ganglion    2972.3 Adult Crop    2093.2 Adult Midgut    4330.8 Adult Hindgut    5075 Adult Malpighian Tubules    6448.4 Adult Fat Body    1276.9 Adult Salivary Gland    11317 Adult Heart    1734.975 Adult VirginFemale Spermatheca    1569.4 Adult InseminatedFemale Spermatheca    1706.6 Adult Ovary    1498.5 Adult Testis    777.3 Adult Male Accessory Gland    1730.4 Adult Carcass    1771.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2099.5   NA  Eye    1648.475   NA  Brain    2409.8   1587.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2972.3   NA  Crop    2093.2   4646.5  Midgut    4330.8   5110.6  Hindgut    5075   3979.8  Malpighian Tubules    6448.4   1624.6  Fat Body    1276.9   3937.6  Salivary Gland    11317   NA  Heart    1734.975   2608.475  Trachea    NA   NA  VirginFemale Spermatheca    1569.4   NA  InseminatedFemale Spermatheca    1706.6   NA  Ovary    1498.5   NA  Testis    777.3   NA  Male Accessory Gland    1730.4   2754.05  Carcass    1771.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015324 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1088-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Vha26 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Vha26CC01380 lethal | embryonic stage Vha26j3E7 lethal | pupal stage, with Scer\GAL4pnr-MD237 Vha26GD7112 Phenotype manifest in Allele Malpighian tubule Vha26j3E7
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Vha26 Class Mutagen Stocks Known lesion Vha26j3E7 P-element activity 1 Yes Vha26C Delta2-3 0 Yes Vha26CC01380 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Vha26 Class Mutagen Stocks Known lesion Vha26GD7112 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Vha26KK109326 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Vha26tMa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6144 (Ryder, 2004.4.26) Df(3R)noi-C (Meyer et al., 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7112} NA P{KK109326} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}noij3E7 No miscellaneous insertions P{PTT-GC}Vha26CC01380 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
hydrogen-exporting ATPase activity, phosphorylative mechanism inferred from sequence or structural similarity with Saccharomyces VMA4 (Dow, 1999) inferred from sequence or structural similarity with UniProtKB:P31402 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) proton-transporting ATPase activity, rotational mechanism inferred from electronic annotation with InterPro:IPR002842 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ATP hydrolysis coupled proton transport inferred from electronic annotation with InterPro:IPR002842 (FlyBase Curators et al., 2004-) proton transport non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Cellular Component
CV term Evidence References
vacuolar proton-transporting V-type ATPase, V1 domain inferred from sequence or structural similarity with Saccharomyces VMA4 (Dow, 1999) inferred from sequence or structural similarity with UniProtKB:P31402 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Vha26 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65885 DroID - A comprehensive database of gene and protein interactions. • FBgn0015324 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40679
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20699 Dere\GG12936 Dgri\GH14669 Dmoj\GI23674 Dper\GL21540 Dpse\GA10614 Dsec\GM10818 Dsim\GD19797 Dvir\GJ23234 Dwil\GK22511 Dyak\GE10141
Curated drosophilid orthologs	Dpse\GA10614
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012035-PA Aedes aegypti (mosquito) AGAP002401-PA Anopheles gambiae (mosquito) XP_625098.1 Apis mellifera (honey bee) XP_001952117.1 Acyrthosiphon pisum (pea aphid) At4g11150.1 Arabidopsis thaliana (wall cress) 35129 Batrachochytrium dendrobatidis (chytrid fungus) 230253 Branchiostoma floridae (lancelet) 232084 Branchiostoma floridae (lancelet) BGIBMGA010247-PA Bombyx mori (silk worm) ENSBTAP00000018925 Bos taurus (bovine) CAL0002571 Candida albicans (a form of yeast) CN25283 Caenorhabditis brenneri (small nematode) CBP01369 Caenorhabditis briggsae (nematode) CE19362 Caenorhabditis elegans (worm) ENSCAFP00000023805 Canis familiaris (dog) CAGL0E05346g Candida glabrata (haploid yeast) Chro.80048 Cryptosporidium hominis (obligate parasite) ENSCINP00000026021 Ciona intestinalis (sea squirt) ENSCINP00000026023 Ciona intestinalis (sea squirt) ENSCINP00000029321 Ciona intestinalis (sea squirt) JA18514 Caenorhabditis japonica (nematode) CMQ010C Cyanidioschyzon merolae (red alga) cn01533 Cryptococcus neoformans (yeast-like fungus) cgd8_360 Cryptosporidium parvum (protozoan parasite) CPIJ006751 Culex pipens (mosquito) ENSCPOP00000015029 Cavia porcellus (guinea pig) 190371 Chlamidomonas reinhardtii (green alga) RP08361 Caenorhabditis remanei (nematode) ENSCSAVP00000004502 Ciona savignyi (sedentary tunicate) 166040 Capitella spl (polychaete worm) DDB0185070 Dictyostelium discoideum (amoeba) DEHA2B05544g Debaryomyces Hansenii (yeast) 230423 Daphnia pulex (daphnia) ENSDARP00000050220 Danio rerio (zebra fish) ENSECAP00000014272 Equus caballus (horse) XP_656703 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000026283 Gymnopilus aculeatus (mushroom) ENSGALP00000021250 Gallus gallus (chicken) GL50803_13603 Giardia lamblia (flagellated protozoan) 169350 Hypsipyla robusta (cedar shoot borer) ENSP00000253413 Homo sapiens (human) ISCW012156-PA Ixodes scapularis (deer tick) KLLA0F02541g Kluyveromyces lactis (yeast) 209321 Lottia gigantea (owl limpet) LmjF36.3100 Leishmania major (virus) 37555 Monocosta brevicollis (choanoflagellate) ENSMODP00000023008 Monodelphis domestica (gray opossum) ENSMMUP00000007124 Macaca mulatta (rhesus monkey) ENSMUSP00000019354 Mus musculus (house mouse) 237075 Nematostella vectensis (starlet anemone) XP_001608260.1 Nasonia vitripennis (wasp) ENSOANP00000005149 Ornithorynchus anatinus (platypus) ENSORLP00000019772 Oryzias latipes (japanese killifish) LOC_Os01g46980.1 Oryza sativa (asian rice) 8689 Ostreococcus tauri (green alga) PFI1670c Plasmodium falciparum (protozoal parasite) PHUM002399-PA Pediculus humanus (human body louse) PP12925 Pristionchus pacificus (nematode) 77945 Physcomitrella patens (moss) ENSPPYP00000013890 Pongo pygmaeus (orangutan) 94247 Phytophthora ramorum (sudden oak death pathogen) 138060 Phytophthora sojae (root rot pathogen) 823689 Populus trichocarpa (black cottonwood) ENSPTRP00000024173 Pan troglodytes (chimpanzee) PVX_086990 Plasmodium vivax (protozoal parasite) ENSRNOP00000016495 Rattus norvegicus (norway rat) 4879458 Sorghum bicolor (sorghum) YOR332W Saccharomyces cerevisiae (budding yeast) Smp_085520 Schistosoma mansoni (trematode parasite) SPAC11E3.07 Schizosaccharomyces pombe (fission yeast) XP_798719.2 Strongylocentrotus purpuratus (purple sea urchin) 63784 Trichoplax adhaerens (metazoa) TA17420 Theileria annulata (apicomplexan parasite) XP_970621.1 Tribolium castaneum (red flour beetle) Tc00.1047053508851.59 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511589.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014358 Tetraodon nigroviridis (green spotted pufferfish) TP03_0853 Theileria parva (parasitic protozoan) 29117 Thalassiosira pseudonana (marine diatom) ENSTRUP00000028567 Takifugu rubripes (pufferfish Takifugu) 16.m00305 Tetrahymena thermophila (ciliate protozoa) 80906.m00263 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000001913 Xenopus tropicalis (frog) YALI0F15631g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18112 NV10403 LH15230 ISCW012156 FBgn0228022 FBgn0224488 FBgn0210336 FBgn0191286 FBgn0165764 JGI_V11_230423 FBgn0070671 FBgn0159133 FBgn0146400 FBgn0122145 FBgn0105209 FBgn0097705 CPIJ006751 BGIBMGA010247 ACYPI006090 GB12913 AGAP002401 AAEL012035 PHUM598510 GLEAN_10367
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	10214 w1118; P{lacW}noij3E7 Vha26j3E7/TM3, P{ftz/lacC}SC1, ryRK Sb1 Ser1
VDRC	v102378 P{KK109326}VIE-260B v45377 w1118; P{GD7112}v45377/TM3
Genomic Clones ( 2 )
	BACR03P13 BACR24O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 228 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03683
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT26768 AT31127 GH03706 GH05041 GH05691 GH09513 GH09528 GH14677 GH16958 GH28750 GM05164 GM06340 GM06712 GM07590 LD03409 LD06452 LD08010 LD08228 LD12255 LD13535 LD14007 LD14158 LD16002 LD20413 LD21886 LD33614 LD33710 LD34875 LD47206 LD47660 LP10296 LP11887 LP14410 LP17224 LP17783 LP21913 RE02202 RE04114 RE04649 RE05357 RE09166 RE10304 RE11361 RE11973 RE13019 RE13955 RE14339 RE14617 RE16035 RE16832 RE16944 RE18496 RE21738 RE25367 RE26212 RE26482 RE26490 RE27564 RE27710 RE28438 RE29329 RE29572 RE30495 RE32825 RE33696 RE33717 RE36229 RE37634 RE40879 RE42792 RE44217 RE44257 RE44884 RE47015 RE47044 RE48237 RE51030 RE52444 RE57252 RE57351 RE57586 RE57635 RE57755 RE58253 RE58364 RE58516 RE59640 RE60888 RE61648 RE65152 RE67587 RE69646 RE70184 RE72107 RE72347 RH22903 RH25627 RH41637 RH49547 RH49556 RH52290 RH60427 RH60533 RH74170 SD02493 SD03569 SD07235 SD07474 SD10014 SD11237 SD11412 SD13801 SD14958
Other clones	10258 34801 54135 79420 97340 103273 105577 108625 125615 148317 164468 191313 bs01b05 CK01.24C.E7 CK01.27A.D5 CK01.95B.D11 CK01.124A.B12 CK01.144B.F1 Dmel_neb_015518_0832_1744 EC01485 EC14241 EC28383 EK074214 EK094438 EK144951 EK179359 EK190504 EK206408 EK219354 EK230802 EK230863 EK242958 EK245057 EK247619 EK267207 EK269120 EK294026 EK306204 EP15509 FGC002A01 FGC006F09 FGM219B10 LD21045 LP20639 RE01183 RE01494 RE01769 RE02303 RE06977 RE11756 RE19260 RE30802 RE35864 RE35976 RE36785 RE52223 RE63891 RE68870 RE69308 RH11355 RH13666 RH19789 RH20123 RH27069 RH29742 RH41383 RH44402 RH49433 RH51159 RH51693 RH51736 RH51861 RH52359 RH52390 RH52796 RH53759 RH54768 RH56631 RH57570 RH61073 RH65969 RH67810 RH70254 RH71547 RH72445 RM07486 RM07586 RM07686 RM07786 RM07986 RP001024794 RP001033520 RP001033542 RP001034300 RP004053766 RP004055523 RP004139772 RP004146860 RP004195950 RP004201254 RP004210496 RP004211058 RP004213100 RP004254647 RP004263116 RP004267607 RP004293247 RP004375656 RP004399034 RP004404392 RP004404756 RP004424926 RP004501826 RP004556476
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015324 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40679
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Vha26 CG1088 (Zheng, 1999.11)
Source for database merge of	Source for merge of: Vha26 anon-83Bb (FlyBase, 1996-) Source for merge of: Vha26 BcDNA:GH03683 (FlyBase, 1996-)
Additional comments	Source for merge of Vha26 BcDNA:GH03683 was sequence comparison (date:990717). (FlyBase, 1996-)
Other Comments
	Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene. (Hansen et al., 2009) dsRNA made from templates generated with primers directed against Vha26 that is transfected into S2 treated with Listeria monocytogenes reveals Vha26 to be involved in Listeria monocytogenes entry and vacuolar escape. (Cheng et al., 2005) Transcription unit identified during molecular analysis of the noi gene region. (Meyer et al., 1998) Isolated using a M.sexta V-ATPase E-subunit cDNA. (Guo et al., 1996) Vha26 has been cloned and characterised. (Guo et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079513 NM_169073 RefSeq (Proteins) • NP_524237 NP_730957 DDBJ / EMBL / GenBank • AA802803 AAB09738 AAB09739 AAD38593 AAF51997 AAF51998 AF145618 AI063718 AI401922 AI944414 U38198 U38951 Entrez Gene - A searchable database of RefSeq genes. • 40679 UniProtKB/Swiss-Prot • P54611
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, V1/A1 complex, subunit E (IPR002842)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65885 DroID - A comprehensive database of gene and protein interactions. • FBgn0015324 DRSC - Results from RNAi screens. • FBgn0015324 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015324 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1088-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015324 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40679 InParanoid A subset of ortholog calls from InParanoid. • AAEL012035-PA Aedes aegypti (mosquito) AGAP002401-PA Anopheles gambiae (mosquito) XP_625098.1 Apis mellifera (honey bee) XP_001952117.1 Acyrthosiphon pisum (pea aphid) At4g11150.1 Arabidopsis thaliana (wall cress) 35129 Batrachochytrium dendrobatidis (chytrid fungus) 230253 Branchiostoma floridae (lancelet) 232084 Branchiostoma floridae (lancelet) BGIBMGA010247-PA Bombyx mori (silk worm) ENSBTAP00000018925 Bos taurus (bovine) CAL0002571 Candida albicans (a form of yeast) CN25283 Caenorhabditis brenneri (small nematode) CBP01369 Caenorhabditis briggsae (nematode) CE19362 Caenorhabditis elegans (worm) ENSCAFP00000023805 Canis familiaris (dog) CAGL0E05346g Candida glabrata (haploid yeast) Chro.80048 Cryptosporidium hominis (obligate parasite) ENSCINP00000026021 Ciona intestinalis (sea squirt) ENSCINP00000026023 Ciona intestinalis (sea squirt) ENSCINP00000029321 Ciona intestinalis (sea squirt) JA18514 Caenorhabditis japonica (nematode) CMQ010C Cyanidioschyzon merolae (red alga) cn01533 Cryptococcus neoformans (yeast-like fungus) cgd8_360 Cryptosporidium parvum (protozoan parasite) CPIJ006751 Culex pipens (mosquito) ENSCPOP00000015029 Cavia porcellus (guinea pig) 190371 Chlamidomonas reinhardtii (green alga) RP08361 Caenorhabditis remanei (nematode) ENSCSAVP00000004502 Ciona savignyi (sedentary tunicate) 166040 Capitella spl (polychaete worm) DDB0185070 Dictyostelium discoideum (amoeba) DEHA2B05544g Debaryomyces Hansenii (yeast) 230423 Daphnia pulex (daphnia) ENSDARP00000050220 Danio rerio (zebra fish) ENSECAP00000014272 Equus caballus (horse) XP_656703 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000026283 Gymnopilus aculeatus (mushroom) ENSGALP00000021250 Gallus gallus (chicken) GL50803_13603 Giardia lamblia (flagellated protozoan) 169350 Hypsipyla robusta (cedar shoot borer) ENSP00000253413 Homo sapiens (human) ISCW012156-PA Ixodes scapularis (deer tick) KLLA0F02541g Kluyveromyces lactis (yeast) 209321 Lottia gigantea (owl limpet) LmjF36.3100 Leishmania major (virus) 37555 Monocosta brevicollis (choanoflagellate) ENSMODP00000023008 Monodelphis domestica (gray opossum) ENSMMUP00000007124 Macaca mulatta (rhesus monkey) ENSMUSP00000019354 Mus musculus (house mouse) 237075 Nematostella vectensis (starlet anemone) XP_001608260.1 Nasonia vitripennis (wasp) ENSOANP00000005149 Ornithorynchus anatinus (platypus) ENSORLP00000019772 Oryzias latipes (japanese killifish) LOC_Os01g46980.1 Oryza sativa (asian rice) 8689 Ostreococcus tauri (green alga) PFI1670c Plasmodium falciparum (protozoal parasite) PHUM002399-PA Pediculus humanus (human body louse) PP12925 Pristionchus pacificus (nematode) 77945 Physcomitrella patens (moss) ENSPPYP00000013890 Pongo pygmaeus (orangutan) 94247 Phytophthora ramorum (sudden oak death pathogen) 138060 Phytophthora sojae (root rot pathogen) 823689 Populus trichocarpa (black cottonwood) ENSPTRP00000024173 Pan troglodytes (chimpanzee) PVX_086990 Plasmodium vivax (protozoal parasite) ENSRNOP00000016495 Rattus norvegicus (norway rat) 4879458 Sorghum bicolor (sorghum) YOR332W Saccharomyces cerevisiae (budding yeast) Smp_085520 Schistosoma mansoni (trematode parasite) SPAC11E3.07 Schizosaccharomyces pombe (fission yeast) XP_798719.2 Strongylocentrotus purpuratus (purple sea urchin) 63784 Trichoplax adhaerens (metazoa) TA17420 Theileria annulata (apicomplexan parasite) XP_970621.1 Tribolium castaneum (red flour beetle) Tc00.1047053508851.59 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511589.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014358 Tetraodon nigroviridis (green spotted pufferfish) TP03_0853 Theileria parva (parasitic protozoan) 29117 Thalassiosira pseudonana (marine diatom) ENSTRUP00000028567 Takifugu rubripes (pufferfish Takifugu) 16.m00305 Tetrahymena thermophila (ciliate protozoa) 80906.m00263 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000001913 Xenopus tropicalis (frog) YALI0F15631g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40679 modMine - Data generated by the modENCODE project. • FBgn0015324 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18112 NV10403 LH15230 ISCW012156 FBgn0228022 FBgn0224488 FBgn0210336 FBgn0191286 FBgn0165764 JGI_V11_230423 FBgn0070671 FBgn0159133 FBgn0146400 FBgn0122145 FBgn0105209 FBgn0097705 CPIJ006751 BGIBMGA010247 ACYPI006090 GB12913 AGAP002401 AAEL012035 PHUM598510 GLEAN_10367
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	anon-83Bb   ATP6V1E1 (Adamson et al., 2011) BcDNA:GH03683   BcDNA.GH03683 (Rubin, 1999.4.23) CG1088 (Labourier et al., 2002, Wang et al., 2004, Hansen et al., 2009, Keleman et al., 2009.8.5, Khanna et al., 2010, Allan et al., 2005, Cammarato et al., 2011) unnamed (Meyer et al., 1998) V-ATPase (Dow and Davies, 2000) vATPase (Whyard et al., 2009) vha26 (Cheng et al., 2005, Guo, 1995.10.19, Guo, 1995.10.10, Dow, 1999, Dow et al., 1997, Guo et al., 1996, Stark et al., 2005, Wang et al., 2004, Allan et al., 2005, Rose et al., 2011, Adamson et al., 2011) Vha26 (Stuart et al., 2007, Buszczak et al., 2007, Hansen et al., 2009, Li et al., 2007, Domanitskaya et al., 2007, Wasbrough et al., 2010, Parisi et al., 2004) VhaE
Name Synonym	E subunit (Dow et al., 1997) vacuolar ATP synthase subunit E (Domanitskaya et al., 2007) Vacuolar H+-ATPase 26kD E subunit (Khanna et al., 2010, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0024707
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Adamson et al., 2011, Genetics 189(2): 495--506 A Drosophila model for genetic analysis of influenza viral/host interactions. [FBrf0216397] Rose et al., 2011, Cell Host Microbe 10(2): 97--104 Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and Mammalian hosts. [FBrf0214675] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...