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Gene Dmel\CG5861

General Information
Symbol	Dmel\CG5861	Species	D. melanogaster
Name		Annotation symbol	CG5861
Feature type	protein_coding_gene	FlyBase ID	FBgn0015338
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	anon-35Fa, BG:DS02740.11
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35F1-35F1	Sequence location	2L:16,305,786..16,307,275 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5861 (FBgn0015338). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein of unknown function DUF2053, membrane. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641285_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5861. Gene sequence location is 2L:16305786..16307275.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN22444 HFA02907
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35F1-35F1   Limits computationally determined from genome sequence between P{lacW}heixk11403&P{lacW}heixk12401 and P{EP}fzyEP1028&P{lacW}mRpL4k14608
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35F-35F     (Dawson et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5861 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5861-RA FBtr0080850  NM_135945   1118   227
Additional Transcript Data & Comments
Reported size (kB)	1.0 (northern blot) (Roth et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5861-PA   FBpp0080407   25.1   227   8.69     NP_609789   AAF53519
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF2053, membrane (IPR019164)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803126   AA803560   AE014134 AAF53519   AI061692   AY071295 AAL48917   BI171506   BI216222   BI236553   BI483372   BI485272   CO182174   CO182440   CO295163   CZ479380   CZ479381   EC075619   EC221444
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3I6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Roth et al., 1995) adult stage     (Roth et al., 1995)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015338    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015338 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015338 expression level Developmental Stage   Expression Level embryo 00-02hr    4759 embryo 02-04hr    3187 embryo 04-06hr    4354 embryo 06-08hr    5000 embryo 08-10hr    5445 embryo 10-12hr    7259 embryo 12-14hr    3703 embryo 14-16hr    2937 embryo 16-18hr    2890 embryo 18-20hr    2550 embryo 20-22hr    1848 embryo 22-24hr    1626 larva L1    2107 larva L2    3828 larva L3 12hr old    2579 larva L3 puffstage 1-2    1404 larva L3 puffstage 3-6    1686 larva L3 puffstage 7-9    2153 white prepupae new    2142 white prepupae 12hr    1716 white prepupae 24hr    2140 pupae 2d postWPP    2083 pupae 3d postWPP    1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day    1570 adult male 30day    1428 adult female 01day    2143 adult female 05day    3401 adult female 30day    3411 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4759) embryo 02-04hr  (3187) embryo 04-06hr  (4354) embryo 06-08hr  (5000) embryo 08-10hr  (5445) embryo 10-12hr  (7259) embryo 12-14hr  (3703) embryo 14-16hr  (2937) embryo 16-18hr  (2890) embryo 18-20hr  (2550) embryo 20-22hr  (1848) embryo 22-24hr  (1626) larva L1  (2107) larva L2  (3828) larva L3 12hr old  (2579) larva L3 puffstage 1-2  (1404) larva L3 puffstage 3-6  (1686) larva L3 puffstage 7-9  (2153) white prepupae new  (2142) white prepupae 12hr  (1716) white prepupae 24hr  (2140) pupae 2d postWPP  (2083) pupae 3d postWPP  (1790) pupae 4d postWPP  (1057) adult male 01day  (1308) adult male 05day  (1570) adult male 30day  (1428) adult female 01day  (2143) adult female 05day  (3401) adult female 30day  (3411) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4759) embryo 02-04hr  (3187) embryo 04-06hr  (4354) embryo 06-08hr  (5000) embryo 08-10hr  (5445) embryo 10-12hr  (7259) embryo 12-14hr  (3703) embryo 14-16hr  (2937) embryo 16-18hr  (2890) embryo 18-20hr  (2550) embryo 20-22hr  (1848) embryo 22-24hr  (1626) larva L1  (2107) larva L2  (3828) larva L3 12hr old  (2579) larva L3 puffstage 1-2  1404 larva L3 puffstage 3-6  (1686) larva L3 puffstage 7-9  (2153) white prepupae new  (2142) white prepupae 12hr  (1716) white prepupae 24hr  (2140) pupae 2d postWPP  (2083) pupae 3d postWPP  (1790) pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day  (1570) adult male 30day  1428 adult female 01day  (2143) adult female 05day  (3401) adult female 30day  (3411) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4759 embryo 02-04hr    3187 embryo 04-06hr    4354 embryo 06-08hr    5000 embryo 08-10hr    5445 embryo 10-12hr    7259 embryo 12-14hr    3703 embryo 14-16hr    2937 embryo 16-18hr    2890 embryo 18-20hr    2550 embryo 20-22hr    1848 embryo 22-24hr    1626 larva L1    2107 larva L2    3828 larva L3 12hr old    2579 larva L3 puffstage 1-2    1404 larva L3 puffstage 3-6    1686 larva L3 puffstage 7-9    2153 white prepupae new    2142 white prepupae 12hr    1716 white prepupae 24hr    2140 pupae 2d postWPP    2083 pupae 3d postWPP    1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day    1570 adult male 30day    1428 adult female 01day    2143 adult female 05day    3401 adult female 30day    3411 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4759 embryo 02-04hr    3187 embryo 04-06hr    4354 embryo 06-08hr    5000 embryo 08-10hr    5445 embryo 10-12hr    7259 embryo 12-14hr    3703 embryo 14-16hr    2937 embryo 16-18hr    2890 embryo 18-20hr    2550 embryo 20-22hr    1848 embryo 22-24hr    1626 larva L1    2107 larva L2    3828 larva L3 12hr old    2579 larva L3 puffstage 1-2    1404 larva L3 puffstage 3-6    1686 larva L3 puffstage 7-9    2153 white prepupae new    2142 white prepupae 12hr    1716 white prepupae 24hr    2140 pupae 2d postWPP    2083 pupae 3d postWPP    1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day    1570 adult male 30day    1428 adult female 01day    2143 adult female 05day    3401 adult female 30day    3411 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015338 expression level Developmental Stage   Expression Level embryo 00-02hr    4759 embryo 02-04hr    3187 embryo 04-06hr    4354 embryo 06-08hr    5000 embryo 08-10hr    5445 embryo 10-12hr    7259 embryo 12-14hr    3703 embryo 14-16hr    2937 embryo 16-18hr    2890 embryo 18-20hr    2550 embryo 20-22hr    1848 embryo 22-24hr    1626 larva L1    2107 larva L2    3828 larva L3 12hr old    2579 larva L3 puffstage 1-2    1404 larva L3 puffstage 3-6    1686 larva L3 puffstage 7-9    2153 white prepupae new    2142 white prepupae 12hr    1716 white prepupae 24hr    2140 pupae 2d postWPP    2083 pupae 3d postWPP    1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day    1570 adult male 30day    1428 adult female 01day    2143 adult female 05day    3401 adult female 30day    3411 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4759) embryo 02-04hr  (3187) embryo 04-06hr  (4354) embryo 06-08hr  (5000) embryo 08-10hr  (5445) embryo 10-12hr  (7259) embryo 12-14hr  (3703) embryo 14-16hr  (2937) embryo 16-18hr  (2890) embryo 18-20hr  (2550) embryo 20-22hr  (1848) embryo 22-24hr  (1626) larva L1  (2107) larva L2  (3828) larva L3 12hr old  (2579) larva L3 puffstage 1-2  (1404) larva L3 puffstage 3-6  (1686) larva L3 puffstage 7-9  (2153) white prepupae new  (2142) white prepupae 12hr  (1716) white prepupae 24hr  (2140) pupae 2d postWPP  (2083) pupae 3d postWPP  (1790) pupae 4d postWPP  (1057) adult male 01day  (1308) adult male 05day  (1570) adult male 30day  (1428) adult female 01day  (2143) adult female 05day  (3401) adult female 30day  (3411) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4759) embryo 02-04hr  (3187) embryo 04-06hr  (4354) embryo 06-08hr  (5000) embryo 08-10hr  (5445) embryo 10-12hr  (7259) embryo 12-14hr  (3703) embryo 14-16hr  (2937) embryo 16-18hr  (2890) embryo 18-20hr  (2550) embryo 20-22hr  1848 embryo 22-24hr  1626 larva L1  2107 larva L2  (3828) larva L3 12hr old  (2579) larva L3 puffstage 1-2  1404 larva L3 puffstage 3-6  1686 larva L3 puffstage 7-9  2153 white prepupae new  2142 white prepupae 12hr  1716 white prepupae 24hr  2140 pupae 2d postWPP  2083 pupae 3d postWPP  1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day  1570 adult male 30day  1428 adult female 01day  2143 adult female 05day  (3401) adult female 30day  (3411) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4759 embryo 02-04hr    3187 embryo 04-06hr    4354 embryo 06-08hr    5000 embryo 08-10hr    5445 embryo 10-12hr    7259 embryo 12-14hr    3703 embryo 14-16hr    2937 embryo 16-18hr    2890 embryo 18-20hr    2550 embryo 20-22hr    1848 embryo 22-24hr    1626 larva L1    2107 larva L2    3828 larva L3 12hr old    2579 larva L3 puffstage 1-2    1404 larva L3 puffstage 3-6    1686 larva L3 puffstage 7-9    2153 white prepupae new    2142 white prepupae 12hr    1716 white prepupae 24hr    2140 pupae 2d postWPP    2083 pupae 3d postWPP    1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day    1570 adult male 30day    1428 adult female 01day    2143 adult female 05day    3401 adult female 30day    3411 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4759 embryo 02-04hr    3187 embryo 04-06hr    4354 embryo 06-08hr    5000 embryo 08-10hr    5445 embryo 10-12hr    7259 embryo 12-14hr    3703 embryo 14-16hr    2937 embryo 16-18hr    2890 embryo 18-20hr    2550 embryo 20-22hr    1848 embryo 22-24hr    1626 larva L1    2107 larva L2    3828 larva L3 12hr old    2579 larva L3 puffstage 1-2    1404 larva L3 puffstage 3-6    1686 larva L3 puffstage 7-9    2153 white prepupae new    2142 white prepupae 12hr    1716 white prepupae 24hr    2140 pupae 2d postWPP    2083 pupae 3d postWPP    1790 pupae 4d postWPP    1057 adult male 01day    1308 adult male 05day    1570 adult male 30day    1428 adult female 01day    2143 adult female 05day    3401 adult female 30day    3411 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015338    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015338 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015338 expression level Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye    541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye  (541.75) Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye    541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye    541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015338 expression level Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye    541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye  541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye    541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    422.25 Larval Midgut    202.6 Larval Hindgut    354.7 Larval Malpighian Tubules    497.5 Larval Fat Body    289.4 Larval Salivary Gland    411.5 Larval Trachea    442.55 Larval Carcass    356.275 Adult Head    289.9 Adult Eye    541.75 Adult Brain    480.6 Adult Thoracic-Abdominal Ganglion    448.5 Adult Crop    261.4 Adult Midgut    314.1 Adult Hindgut    325.5 Adult Malpighian Tubules    376.8 Adult Fat Body    298 Adult Salivary Gland    234.6 Adult Heart    301.6 Adult VirginFemale Spermatheca    289.8 Adult InseminatedFemale Spermatheca    264.4 Adult Ovary    447.2 Adult Testis    187.1 Adult Male Accessory Gland    90.6 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    289.9   NA  Eye    541.75   NA  Brain    480.6   422.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    448.5   NA  Crop    261.4   202.6  Midgut    314.1   354.7  Hindgut    325.5   497.5  Malpighian Tubules    376.8   289.4  Fat Body    298   411.5  Salivary Gland    234.6   NA  Heart    301.6   442.55  Trachea    NA   NA  VirginFemale Spermatheca    289.8   NA  InseminatedFemale Spermatheca    264.4   NA  Ovary    447.2   NA  Testis    187.1   NA  Male Accessory Gland    90.6   356.275  Carcass    245.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015338 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5861-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5861GD1742 CG5861GD17134 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG5861 Class Mutagen Stocks Known lesion CG5861G18171 P-element activity 1 -- CG5861e01569 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5861 Class Mutagen Stocks Known lesion CG5861GD17134 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5861GD1742 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5861KK102378 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5861t14.2 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)III18 (Roth et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1742} NA P{GD17134} NA P{KK102378} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG5861e01569 NA insertion of mobile activating element P{EP}CG5861G18171 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5861 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0015338 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34965
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15326 Dere\GG24174 Dgri\GH11431 Dmoj\GI14704 Dper\GL14091 Dpse\GA19185 Dsec\GM17912 Dsim\GD21922 Dvir\GJ17164 Dwil\GK23717 Dyak\GE19368
Curated drosophilid orthologs	Dpse\GA19185
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL015202-PA Aedes aegypti (mosquito) AGAP008757-PA Anopheles gambiae (mosquito) XP_392351.2 Apis mellifera (honey bee) XP_001950587.1 Acyrthosiphon pisum (pea aphid) At1g47640.1 Arabidopsis thaliana (wall cress) 123433 Branchiostoma floridae (lancelet) 288026 Branchiostoma floridae (lancelet) XP_001892565.1 Brugia malayi (roundworm nematode) BGIBMGA010309-PA Bombyx mori (silk worm) ENSBTAP00000021170 Bos taurus (bovine) CN12381 Caenorhabditis brenneri (small nematode) CBP18766 Caenorhabditis briggsae (nematode) CE28189 Caenorhabditis elegans (worm) ENSCAFP00000010348 Canis familiaris (dog) ENSCINP00000014076 Ciona intestinalis (sea squirt) JA06401 Caenorhabditis japonica (nematode) ENSCPOP00000016924 Cavia porcellus (guinea pig) RP22058 Caenorhabditis remanei (nematode) ENSCSAVP00000010936 Ciona savignyi (sedentary tunicate) 171355 Capitella spl (polychaete worm) DDB0233389 Dictyostelium discoideum (amoeba) 303073 Daphnia pulex (daphnia) ENSDARP00000058382 Danio rerio (zebra fish) ENSECAP00000009774 Equus caballus (horse) ENSGACP00000007891 Gymnopilus aculeatus (mushroom) 108721 Hypsipyla robusta (cedar shoot borer) ENSP00000222284 Homo sapiens (human) ISCW018735-PA Ixodes scapularis (deer tick) 186468 Lottia gigantea (owl limpet) ENSMODP00000017396 Monodelphis domestica (gray opossum) ENSMMUP00000001135 Macaca mulatta (rhesus monkey) ENSMUSP00000006478 Mus musculus (house mouse) 248033 Nematostella vectensis (starlet anemone) XP_001607497.1 Nasonia vitripennis (wasp) ENSORLP00000007564 Oryzias latipes (japanese killifish) LOC_Os03g55730.1 Oryza sativa (asian rice) PHUM003224-PA Pediculus humanus (human body louse) PP05518 Pristionchus pacificus (nematode) 107440 Physcomitrella patens (moss) ENSPPYP00000011048 Pongo pygmaeus (orangutan) 816497 Populus trichocarpa (black cottonwood) 826764 Populus trichocarpa (black cottonwood) ENSPTRP00000018571 Pan troglodytes (chimpanzee) PVX_094545 Plasmodium vivax (protozoal parasite) ENSRNOP00000028514 Rattus norvegicus (norway rat) 147129 Sorghum bicolor (sorghum) Smp_071560 Schistosoma mansoni (trematode parasite) XP_001187070.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001200658.1 Strongylocentrotus purpuratus (purple sea urchin) 61929 Trichoplax adhaerens (metazoa) XP_968280.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022283 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044473 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014925 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10913 NV14949 LH14604 ISCW018735 FBgn0236713 FBgn0225679 FBgn0204341 FBgn0193338 FBgn0172819 JGI_V11_303073 FBgn0079182 FBgn0151696 FBgn0137455 FBgn0118911 FBgn0116307 FBgn0092351 BGIBMGA010309 ACYPI010168 GB15680 AGAP008757 AAEL015202 PHUM347570 GLEAN_07856
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27436 y1 w*; P{EP}CG5861G18171
VDRC	v108302 P{KK102378}VIE-260B v47665 w1118; P{GD17134}v47665 v6360 w1118; P{GD1742}v6360/TM3
Genomic Clones ( 1 )
	BACR01N08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE32624
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM07085 GM13502 LD33770 RE13295 RE23169 RE66254 RE68572
Other clones	79176 EC22209 EC22667 EK208763
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015338 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34965
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: anon-35Fc anon-35Fa (Dawson et al., 1995)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135945 RefSeq (Proteins) • NP_609789 DDBJ / EMBL / GenBank • AA803126 AAF53519 AAL48917 AE003415 AI061692 AY071295 BI236553 CZ479380 CZ479381 Entrez Gene - A searchable database of RefSeq genes. • 34965 UniProtKB/TrEMBL • Q9V3I6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF2053, membrane (IPR019164)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0015338 DRSC - Results from RNAi screens. • FBgn0015338 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015338 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5861-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015338 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34965 InParanoid A subset of ortholog calls from InParanoid. • AAEL015202-PA Aedes aegypti (mosquito) AGAP008757-PA Anopheles gambiae (mosquito) XP_392351.2 Apis mellifera (honey bee) XP_001950587.1 Acyrthosiphon pisum (pea aphid) At1g47640.1 Arabidopsis thaliana (wall cress) 123433 Branchiostoma floridae (lancelet) 288026 Branchiostoma floridae (lancelet) XP_001892565.1 Brugia malayi (roundworm nematode) BGIBMGA010309-PA Bombyx mori (silk worm) ENSBTAP00000021170 Bos taurus (bovine) CN12381 Caenorhabditis brenneri (small nematode) CBP18766 Caenorhabditis briggsae (nematode) CE28189 Caenorhabditis elegans (worm) ENSCAFP00000010348 Canis familiaris (dog) ENSCINP00000014076 Ciona intestinalis (sea squirt) JA06401 Caenorhabditis japonica (nematode) ENSCPOP00000016924 Cavia porcellus (guinea pig) RP22058 Caenorhabditis remanei (nematode) ENSCSAVP00000010936 Ciona savignyi (sedentary tunicate) 171355 Capitella spl (polychaete worm) DDB0233389 Dictyostelium discoideum (amoeba) 303073 Daphnia pulex (daphnia) ENSDARP00000058382 Danio rerio (zebra fish) ENSECAP00000009774 Equus caballus (horse) ENSGACP00000007891 Gymnopilus aculeatus (mushroom) 108721 Hypsipyla robusta (cedar shoot borer) ENSP00000222284 Homo sapiens (human) ISCW018735-PA Ixodes scapularis (deer tick) 186468 Lottia gigantea (owl limpet) ENSMODP00000017396 Monodelphis domestica (gray opossum) ENSMMUP00000001135 Macaca mulatta (rhesus monkey) ENSMUSP00000006478 Mus musculus (house mouse) 248033 Nematostella vectensis (starlet anemone) XP_001607497.1 Nasonia vitripennis (wasp) ENSORLP00000007564 Oryzias latipes (japanese killifish) LOC_Os03g55730.1 Oryza sativa (asian rice) PHUM003224-PA Pediculus humanus (human body louse) PP05518 Pristionchus pacificus (nematode) 107440 Physcomitrella patens (moss) ENSPPYP00000011048 Pongo pygmaeus (orangutan) 816497 Populus trichocarpa (black cottonwood) 826764 Populus trichocarpa (black cottonwood) ENSPTRP00000018571 Pan troglodytes (chimpanzee) PVX_094545 Plasmodium vivax (protozoal parasite) ENSRNOP00000028514 Rattus norvegicus (norway rat) 147129 Sorghum bicolor (sorghum) Smp_071560 Schistosoma mansoni (trematode parasite) XP_001187070.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001200658.1 Strongylocentrotus purpuratus (purple sea urchin) 61929 Trichoplax adhaerens (metazoa) XP_968280.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022283 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044473 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014925 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34965 modMine - Data generated by the modENCODE project. • FBgn0015338 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10913 NV14949 LH14604 ISCW018735 FBgn0236713 FBgn0225679 FBgn0204341 FBgn0193338 FBgn0172819 JGI_V11_303073 FBgn0079182 FBgn0151696 FBgn0137455 FBgn0118911 FBgn0116307 FBgn0092351 BGIBMGA010309 ACYPI010168 GB15680 AGAP008757 AAEL015202 PHUM347570 GLEAN_07856
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-35Fa (Reese et al., 2000, Reese et al., 2000, ) anon-35Fc   BG:DS02740.11 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG5861 (Stroschein-Stevenson et al., 2006, Keleman et al., 2009.8.5) III (Dawson et al., 1995) unnamed (Ashburner et al., 1999, Roth et al., 1995)
Name Synonym
Secondary FlyBase IDs
	FBgn0020603
References ( 19 )
Research paper	Stroschein-Stevenson et al., 2006, PLoS Biol. 4(1): 87--99 Identification of Drosophila gene products required for phagocytosis of Candida albicans. [FBrf0191376] Willingham and Keil, 2004, Mech. Dev. 121(10): 1289--1297 A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. [FBrf0179737] Bolshakov et al., 2002, Genome Res. 12(1): 57--66 A comparative genomic analysis of two distant Diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. [FBrf0141561] Reese et al., 2000, Genome Res. 10(4): 483--501 Genome annotation assessment in Drosophila melanogaster. [FBrf0127290] Reese et al., 2000, Genome Res. 10(4): 529--538 Genie - Gene finding in Drosophila melanogaster. [FBrf0127289] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Dawson et al., 1995, J. Cell Biol. 129(3): 725--737 The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. [FBrf0081900] Roth et al., 1995, Cell 81(6): 967--978 cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. [FBrf0082538]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Ashburner et al., 1999, Genetics 153(1): Table S2. Genes, known and predicted, that have been determined on the sequence of the Adh region. All genes are protein coding, unless indicated tscan in the prediction column, these are tRNAs. [FBrf0112151]
Personal communication to FlyBase	Bellen, 2009.5.5, BDGP_2009_0507.GenExel.xml BDGP_2009_0507.GenExel.xml [FBrf0207859] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]