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Gene Dmel\btb

General Information
Symbol	Dmel\btb	Species	D. melanogaster
Name	bumper-to-bumper	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0015368
Gene Model Status	Unannotated	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)		Recombination map
Cytogenetic map	47A-47B	Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene bumper-to-bumper is referred to in FlyBase by the symbol Dmel\btb (FBgn0015368). It is a gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed RNA polymerase activity. Based on sequence similarity, it is predicted to be involved in the biological process: transcription from RNA polymerase III promoter. One allele is reported. The phenotype of this allele is annotated with: presumptive embryonic/larval peripheral nervous system. It has no annotated transcripts. Gene has not been localized to the genome sequence.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47A-47B   Left limit from in situ hybridisation (FBrf0080145) Right limit from in situ hybridisation (FBrf0080145)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 47A-47B     (Prokopenko, 1999.8.5) 47A-47B   (determined by in situ hybridisation)   (Kania et al., 1995) 47A1-47B14     (BDGP Project Members, 1994-1999) 47A-47B14   Location based on in situ hybridisation using flanking plasmid rescue sequence from the P{lacW}btbk09901 insertion. (determined by in situ hybridisation)   (Prokopenko et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF175907   AF175908
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive btbk09901 lethal | recessive btbk09901 Phenotype manifest in Allele chordotonal organ | lateral btbk09901 presumptive embryonic/larval peripheral nervous system btbk09901
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of btb Class Mutagen Stocks Known lesion btbk09901 P-element activity 2 Yes
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of btb Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}btbk09901 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA-directed RNA polymerase activity inferred from sequence or structural similarity with CG5380 (Prokopenko et al., 2000)
Biological Process
CV term Evidence References
peripheral nervous system development traceable author statement (Prokopenko et al., 2000) transcription from RNA polymerase III promoter inferred from sequence or structural similarity with CG5380 (Prokopenko et al., 2000)
Cellular Component
CV term Evidence References
DNA-directed RNA polymerase III complex inferred from sequence or structural similarity with CG5380 (Prokopenko et al., 2000)
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions btb allele Gene References
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	10422 y1 w67c23; P{lacW}btbk09901/CyO
Kyoto	111093 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}btbk09901 /CyO y+
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase curator comment: FBrf0194763 states that "btb[k09901]" is an allele of the "lola" gene, based on the failure of "btb[k09901]" to complement lola[00642], lola[5D2], lola[ORC4], lola[ORE50], lola[4E4] and lola[ORE120]. However, FBrf0131381 states that "btb[k09901]" complements lola[5D2] and lola[A307]. Due to this conflicting complementation data, and due to the fact that there is also conflicting data about the localisation of the insertion in "btb[k09901]", depending on whether in situ or flanking sequence data is used (see FBrf0131381), the "btb[k09901]" allele and parent "btb" gene have been kept separate from the "lola" gene in FlyBase until more information is available to resolve these conflicts (date: 100104). (Paige Bass et al., 2007) The flanking sequence of the P{lacW}btbk09901 insertion maps by BLAST in the region of "CG5380" (the insertion maps 418bp upstream of the AUG codon), and the P{lacW} insertion may therefore affect this gene. <up>Note, at the time of curation CG5380 is computed to be located at 94A, however, in situ hybridisation to polytene chromosomes using the flanking sequence isolated from P{lacW}btbk09901 results in a signal at 47A--47B</up>. (Prokopenko et al., 2000)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AF175907 AF175908
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	btb (Paige Bass et al., 2007)
Name Synonym	bumper-to-bumper (Paige Bass et al., 2007)
Secondary FlyBase IDs
References ( 8 )
Research paper	Paige Bass et al., 2007, Dev. Biol.: The axon guidance gene lola is required for programmed cell death in the Drosophila ovary. [FBrf0194763] Prokopenko et al., 2000, Genetics 156(4): 1691--1715 Mutations affecting the development of the peripheral nervous system in Drosophila: A molecular screen for novel proteins. [FBrf0131381] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Kania et al., 1995, Genetics 139(4): 1663--1678 P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. [FBrf0080145]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032]
Abstract	Prokopenko and Bellen, 2000, A. Dros. Res. Conf. 41: 727C From phenotype to gene function: A molecular screen for novel genes required for the development of the peripheral nervous system. [FBrf0125877]
DNA/RNA sequence record	Prokopenko, 1999.8.5, GenBank/EMBL/DDBJ: AF175907 Drosophila melanogaster btb[k09901] P element insertion region. [FBrf0124843]
Computer file	BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]