FlyBase Gene Report: Dmel\cutlet

General Information

Symbol

Dmel\cutlet

Species

D. melanogaster

Name

cutlet

Annotation Symbol

CG33122

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015376

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

24C1-24C1

Sequence location

2L:3,707,230..3,711,748 [-]

Recombination map

2-11

RefSeq locus

NT_033779 REGION:3707230..3711748

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR003959

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003959

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000406286

(assigned by GO_Central )

(Gaudet et al., 2011)

contributes_to DNA clamp loader activity

inferred from sequence or structural similarity with UniProtKB:Q8WVB6

(FlyBase Curators, 2008--)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in positive regulation of DNA-directed DNA polymerase activity

inferred from sequence or structural similarity with UniProtKB:Q8WVB6

(FlyBase Curators, 2008--)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Jaffe and Jongens, 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of Ctf18 RFC-like complex

inferred from sequence or structural similarity with UniProtKB:Q8WVB6

(FlyBase Curators, 2008--)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000406286

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

RFC COMPLEX ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RFC COMPLEX ATPASES -: Replication factor C (RFC) complexes act as loaders or unloaders of the proliferating cell nuclear antigen (PCNA) (or related sliding clamp complexes) during DNA replication- and/or repair-linked processes. The classic RFC1-RFC complex (comprising RFC1 and four smaller subunits, RFC2-5) and Ctf18-RFC (in which RFC1 is substituted with Ctf1 and two other smaller proteins) fundamentally function as PCNA loaders. Rad17-RFC (in which RFC1 is substituted with Rad17) loads the PCNA-like hetero-trimeric 9-1-1 complex at damaged DNA sites. On the other hand, Elg1-RFC (in which RFC1 is substituted for Elg1) functions as a PCNA unloader, removing PCNA from chromatin after DNA synthesis. RFC1-5, Ctf1, Rad17 and Elg1 belong to the AAA+ ATPase family. (Adapted from PMID:28134787.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cutlet for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cutlet-RA

FBtr0077541

NM_175955

3236

993

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

cutlet-PA

FBpp0077230

111.7

993

8.75

NP_787969

AAN10380

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cutlet using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cutlet_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 7 -- 8

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium