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General Information
Symbol
Dmel\drl
Species
D. melanogaster
Name
derailed
Annotation Symbol
CG17348
Feature Type
FlyBase ID
FBgn0015380
Gene Model Status
Stock Availability
Gene Snapshot
derailed (drl) encodes an atypical receptor tyrosine kinase with the product of Wnt5 as a ligand. It controls axon guidance events during neural development. [Date last reviewed: 2019-03-07]
Also Known As
lio, linotte
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:19,190,342..19,208,621 [+]
Recombination map
2-54
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. (Q27324)
Summaries
Gene Group (FlyBase)
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
PUTATIVE PSEUDOKINASES -
Pseudokinases have protein kinase domains but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).
Protein Function (UniProtKB)
Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.
(UniProt, Q27324)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\drl or the JBrowse view of Dmel\drl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UAA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0081195
3104
610
FBtr0330209
3104
645
Additional Transcript Data and Comments
Reported size (kB)
3.1 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0080736
68.3
610
6.06
FBpp0303242
72.4
645
6.90
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain
The extracellular WIF domain is responsible for Wnt binding.
(UniProt, Q27324)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drl using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (32 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719
(assigned by InterPro )
traceable author statement
(assigned by ParkinsonsUK-UCL )
Biological Process (21 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Ubx; FB:FBgn0003944
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
traceable author statement
(assigned by ParkinsonsUK-UCL )
inferred from biological aspect of ancestor with PANTHER:PTN002521291
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
traceable author statement
(assigned by ParkinsonsUK-UCL )
inferred from biological aspect of ancestor with PANTHER:PTN002521291
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266
(assigned by InterPro )
traceable author statement
(assigned by ParkinsonsUK-UCL )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
traceable author statement
(assigned by ParkinsonsUK-UCL )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
ectoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

ventral nerve cord | restricted

Comment: anterior part of each segment

Additional Descriptive Data
In stage 12 embryos, drl is expressed in the posterior lobe but not in the anterior lobe of the optic primordium.
drl is expressed in neuronal cell bodies that send projections to the anterior commissure.
drl transcripts are expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. They are enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and are no longer detected by hour 15.
drl transcript expression is restricted to the cell bodies of a cluster of about 20 interneurons per hemisegment. Expression commences postmitotically in the neurons as they begin elongating axons and continues throughout embryogenesis.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
drl-protein is expressed in six large groups of cells in the dorsomedial part of the third instar larval brain. At 24 APF drl-protein is detected in cells of the protocerebrum surrounding the mushroom body. At 48 APF the extracellular domain of drl can be detected at the tips of mushroom body lobes alpha and beta. Higher levels are detected at the tip of alpha lobes compared to beta lobes.
drl-protein is detected at 16h APF throughout the developing antennal lobes with high concentrations in the dorsolateral region. drl-protein is co-expressed with Scer\GAL4GH146 and Wnt5-protein in dendrites of a subset of antennal lobe projection neurons.
In pupae of 21hrs APF to 42hrs APF, drl is detectable in discrete regions of the antennal lobe, with strong expression in the lateral-ventral portion of the anterior antennal lobe, and only in the dorso-lateral region of the posterior antennal lobe.
In the late embryonic brain, two commissural tracts express drl protein; these tracts do not co-express Fas3, and the axonal growth cones of embryonic Kenyon cells are closesly apposed to them. In the third instar larval brain, drl protein is expressed in a complex pattern characterized by a lack of colocalization with with Fas2-positive mushroom body axons. Expression is observed in four glial cells, located in the posterior part of the larval brain, whose processes wrap around the mushroom body lobes. drl immunoreactivity is also observed in brain commissures, in the optic lobe and incoming photoreceptor axons, and in commissural neurons of the thoracico-abdominal ganglion.
drl protein was localized to projection neuron dendrites during glomerular development and was found to function in glial cells.
drl protein is first detected in larvae at the early third instar stage and increases until pupation. It is then detected in the optic lobe anlage and in the interhemispheric area, near the commissure. A dynamic expression pattern is also observed in the central area of the larval brain.
drl protein is detected in the epidermis and mesoderm during embyogenesis. It is expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. It is first detected at hour 10 of development, is enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and is no longer detected by hour 15. drl protein is detected in the epidermis starting at hour 6 in stripes 3-4 cells wide in each segment. It is restricted to the anterior of eac segment during segmental groove formation and then at hour 9.5 expands posteriorly from the grooves, resulting in patches of drl-expressing cells. The patches become more refined and are positioned around the dorsal and ventral attachment sites for lateral transverse muscles 1-3.
drl protein is localized to the growth cones and axons of the drl-expressing neurons as they cross the anterior commissure. After they have turned anteriorly, drl protein cannot be detected in the part of the axons within the connectives and is restricted to axon segments within the anterior commissure.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\drl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of drl
Transgenic constructs containing regulatory region of drl
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
8 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919047B )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503YG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03U7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03RF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0353 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (19)
9 of 10
8 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 2 )
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-54
    Cytogenetic map
    Sequence location
    2L:19,190,342..19,208,621 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    37C7-37C7
    Limits computationally determined from genome sequence between P{lacW}bratk06028&P{lacW}l(2)k09613k09613 and P{EP}dntEP2158
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    37D-37D
    (determined by in situ hybridisation)
    37C-37C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (22)
    Genomic Clones (31)
    cDNA Clones (70)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: drl CG10758 CG17348
    Additional comments
    Release 1 annotation CG10758 corresponds to part of the release 3.2 annotation for drl (CG17348).
    The gene described as 'lio' in FBrf0083123 is drl (FBgn0015380), as is made clear by comparison of molecular maps in FBrf0083123 and FBrf0083785.
    FlyBase curator comment: pigeon and drl are neighboring genes, pigeon being 5' and distal to drl. Confusingly, both pigeon and drl have been referred to as 'lio' in the literature. e.g. the gene described as 'lio' in FBrf0083123 is drl (FBgn0015380), the gene described as 'lio' in FBrf0083785 is pigeon (FBgn0010309).
    Other Comments
    drl is required for mushroom body α branch axon guidance during brain development. drl protein is expressed in the dorsomedial lineages adjacent to the mushroom bodies and acts to capture and present Wnt5 protein to mushroom body axons (rather than transducing a Wnt5 signal). The drl ectodomain must be cleaved and shed to guide the α axons. Biochemical data indicates that a cleaved and shed drl extracellular domain can form a ternary complex with Wnt5 and Drl-2, providing a mechanism by which mushroom body α axon guidance may occur, since these axons express Drl-2 protein.
    drl functions cell-autonomously in the projection neurons to promote the targeting of their dendrites to the dorsolateral region of the adult antennal lobe.
    drl and Wnt5 are required (in the salivary gland and in the central nervous system respectively) for normal salivary gland migration in the embryo. They are required in the third phase of migration, to mediate the final positioning of the gland, as the salivary gland detaches from the circular visceral mesoderm and contacts the longitudinal visceral mesoderm.
    drl functions in glial cells, where it acts upstream of Wnt5 to modulate its function in glomerular patterning of the antennal lobe.
    When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in cytokinetic index is seen.
    drl is essential for Wnt (Wnt5) mediated axon guidance.
    Mutation of drl causes behavioral defects independently of pigeon.
    The memory phenotype of drl mutants appears to be a consequence of abnormal brain development due to loss of function of the drl receptor tyrosine kinase.
    A predicted kinase-deficient drl transgene retains drl function in two separate assays, suggesting that drl does not require kinase activity in vivo.
    Expression of drl in each of four subclasses of anterior commissural neurons is controlled by separate transcriptional regulatory sequences.
    drl acts as a guidance receptor for a repellent ligand present in the posterior commissure in the developing embryonic nervous system.
    P-element transformation vectors containing drl regulatory sequences show insertion site homing capability.
    drl mutants show structural brain defects in the adult central complex and mushroom bodies.
    Loss of drl function is responsible for ventral attachment defects, muscle phenotype can be rescued by expression of a drl cDNA.
    Neurons and muscles use common mechanisms to recognise their paths or targets. drl plays an analogous role in both developing systems.
    drl maps 70kb proximal to Ddc.
    drl plays a key controlling role in the multiple discrete steps of neuronal pathway recognition. Results predict that once activated by its ligand drl controls pathway selection by modulating the function of specific cell adhesion molecules that mediate proper axon fasciculation.
    The drl gene product may be part of an atypical signal transduction cascade involved in the development of the adult brain.
    Behaviour-genetic data suggests that 'lio' is non-vital.
    'lio' is involved with learning and memory.
    Origin and Etymology
    Discoverer
    Etymology
    In French someone who forgets everything is said to be a "tete de linotte," the equivalent of bird-brain in English.
    Identification
    External Crossreferences and Linkouts ( 51 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (12)
    Reported As
    Symbol Synonym
    Secondary FlyBase IDs
    • FBgn0032764
    • FBgn0032765
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (202)