-protein is expressed in six large groups of cells in the dorsomedial part of the third instar larval brain. At 24 APF drl
-protein is detected in cells of the protocerebrum surrounding the mushroom body. At 48 APF the extracellular domain of drl
can be detected at the tips of mushroom body lobes alpha and beta. Higher levels are detected at the tip of alpha lobes compared to beta lobes.
-protein is detected at 16h APF throughout the developing antennal lobes with high concentrations in the dorsolateral region. drl
-protein is co-expressed with Scer\GAL4GH146
-protein in dendrites of a subset of antennal lobe projection neurons.
In pupae of 21hrs APF to 42hrs APF, drl
is detectable in discrete regions of the antennal lobe, with strong expression in the lateral-ventral portion of the anterior antennal lobe, and only in the dorso-lateral region of the posterior antennal lobe.
In the late embryonic brain, two commissural tracts express drl
protein; these tracts do not co-express Fas3, and the axonal growth cones of embryonic Kenyon cells are closesly apposed to them. In the third instar larval brain, drl
protein is expressed in a complex pattern characterized by a lack of colocalization with with Fas2
-positive mushroom body axons. Expression is observed in four glial cells, located in the posterior part of the larval brain, whose processes wrap around the mushroom body lobes. drl
immunoreactivity is also observed in brain commissures, in the optic lobe and incoming photoreceptor axons, and in commissural neurons of the thoracico-abdominal ganglion.
protein was localized to projection neuron dendrites during glomerular development and was found to function in glial cells.
protein is first detected in larvae at the early third instar stage and increases until pupation. It is then detected in the optic lobe anlage and in the interhemispheric area, near the commissure. A dynamic expression pattern is also observed in the central area of the larval brain.
protein is detected in the epidermis and mesoderm during embyogenesis. It is expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. It is first detected at hour 10 of development, is enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and is no longer detected by hour 15. drl
protein is detected in the epidermis starting at hour 6 in stripes 3-4 cells wide in each segment. It is restricted to the anterior of eac segment during segmental groove formation and then at hour 9.5 expands posteriorly from the grooves, resulting in patches of drl
-expressing cells. The patches become more refined and are positioned around the dorsal and ventral attachment sites for lateral transverse muscles 1-3.
protein is localized to the growth cones and axons of the drl
-expressing neurons as they cross the anterior commissure. After they have turned anteriorly, drl
protein cannot be detected in the part of the axons within the connectives and is restricted to axon segments within the anterior commissure.