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Gene Dmel\drl

General Information
Symbol	Dmel\drl	Species	D. melanogaster
Name	derailed	Annotation symbol	CG17348
Feature type	protein_coding_gene	FlyBase ID	FBgn0015380
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	lio
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	37C7-37C7	Sequence location	2L:19,190,346..19,208,615 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene derailed is referred to in FlyBase by the symbol Dmel\drl (CG17348, FBgn0015380). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-protein binding. There is experimental evidence that it is involved in the biological process: olfactory learning; axon guidance; learning or memory; memory; haltere development; signal transduction; muscle attachment; salivary gland morphogenesis; axon midline choice point recognition. 36 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; hypodermal muscle of larval abdomen; organ system; A1-7 transverse muscle; adult segment; non-connected developing system; abdominal 1 transverse muscle; cell body; abdominal 2 lateral transverse muscle 2; embryonic foregut. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; WIF domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1624297_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of drl. Gene sequence location is 2L:19190346..19208615.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA03523 BKN50593 BKN45155 BKN23301 BKN50331 References Carreira et al., 2011, BMC Dev. Biol. 11: 32
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37C7-37C7   Limits computationally determined from genome sequence between P{lacW}bratk06028&P{lacW}l(2)k09613k09613 and P{EP}dntEP2158
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37C-37C     (Callahan, 1995.9.13) 37D-37D   (determined by in situ hybridisation)   (Bolwig et al., 1995) 37C-37C   (determined by in situ hybridisation)   (Callahan et al., 1995) 37D-37D   (determined by in situ hybridisation)   (Dura et al., 1993)
Experimentally Determined Recombination Data
Location	2- (Callahan, 1995.9.13)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\drl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) drl-RA FBtr0081195  NM_057791   3094   610
Additional Transcript Data & Comments
Reported size (kB)	3.1 (longest cDNA) (Callahan et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein drl-PA   FBpp0080736   68.3   610   6.06     NP_477139   AAF53776
Additional Polypeptide Data & Comments
Reported size (kDa)	610 (aa) (Callahan et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) WIF domain (IPR003306) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567487   AE014134 AAF53776   AC005440   AC007176   AF147883 AAD41343   AI512011   AI518833   AQ074081   AW943271   AY051852 AAK93276   BF490347   BF490661   BF494203   BI167725   BI173509   BI234568   BI235566   BI357110   BI357777   BI361661   BI361981   BI364149   BI365233   BI365737   BI366675   BI370521   BI565586   BI569297   BI569298   BI569603   BI591013   BI591717   BI606632   BI607225   BI613415   BI618712   BI629365   BI630261   CK657942   CK658475   CO269833   CO270719   CO273004   CO273631   CO283271   CO293451   CO294583   CO295424   CO300332   CO303486   CO304548   CO306585   CO306618   CO307795   CO309827   CO310972   CO324601   CZ477951   CZ478279   CZ486769   EC051311   EC052334   EC053335   EC056541   EC059872   EC062437   EC072004   EC075219   EC075949   EC077094   EC086299   EC087107   EC088584   EC201393   EC202829   EC213490   EC214859   EC222393   EC231729   EC256864   FF579591   L47260 AAA75347   U36584 AAA79949
UniProtKB/Swiss-Prot	Q27324
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   interneuron   (Callahan et al., 1995) embryonic stage 13 -- 16   abdominal 2 lateral transverse muscle 1 -- abdominal 7 lateral transverse muscle 1   (Callahan et al., 1996) Comment:reference states 10-14 hr AEL abdominal 2 lateral transverse muscle 2 -- abdominal 7 lateral transverse muscle 2   (Callahan et al., 1996) Comment:reference states 10-14 hr AEL abdominal 2 lateral transverse muscle 3 -- abdominal 7 lateral transverse muscle 3   (Callahan et al., 1996) Comment:reference states 10-14 hr AEL
Additional Descriptive Data
	drl transcript expression is restricted to the cell bodies of a cluster of about 20 interneurons per hemisegment. Expression commences postmitotically in the neurons as they begin elongating axons and continues throughout embryogenesis. (Callahan et al., 1995) drl transcripts are expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. They are enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and are no longer detected by hour 15. (Callahan et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   anterior commissure   (Callahan et al., 1995) interneuron   (Callahan et al., 1995) embryonic stage 11 -- 15   epidermis | restricted   (Callahan et al., 1996) Comment:6-14 hr AEL embryonic stage 13 -- 16   abdominal 2 lateral transverse muscle 1 -- abdominal 7 lateral transverse muscle 1   (Callahan et al., 1996) Comment:reference states 10-14 hr AEL abdominal 2 lateral transverse muscle 2 -- abdominal 7 lateral transverse muscle 2   (Callahan et al., 1996) Comment:reference states 10-14 hr AEL abdominal 2 lateral transverse muscle 3 -- abdominal 7 lateral transverse muscle 3   (Callahan et al., 1996) Comment:reference states 10-14 hr AEL third instar larval stage   embryonic/larval brain | restricted   (Simon et al., 1998) embryonic/larval optic lobe   (Simon et al., 1998) pupal stage P6 -- P7   antennal lobe | restricted   (Sakurai et al., 2009) pupal stage P7   antennal lobe glomerulus DA1   (Sakurai et al., 2009)
Additional Descriptive Data
	drl protein is detected in the epidermis and mesoderm during embyogenesis. It is expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. It is first detected at hour 10 of development, is enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and is no longer detected by hour 15. drl protein is detected in the epidermis starting at hour 6 in stripes 3-4 cells wide in each segment. It is restricted to the anterior of eac segment during segmental groove formation and then at hour 9.5 expands posteriorly from the grooves, resulting in patches of drl-expressing cells. The patches become more refined and are positioned around the dorsal and ventral attachment sites for lateral transverse muscles 1-3. (Callahan et al., 1996) drl protein is localized to the growth cones and axons of the drl-expressing neurons as they cross the anterior commissure. After they have turned anteriorly, drl protein cannot be detected in the part of the axons within the connectives and is restricted to axon segments within the anterior commissure. (Callahan et al., 1995) drl protein is first detected in larvae at the early third instar stage and increases until pupation. It is then detected in the optic lobe anlage and in the interhemispheric area, near the commissure. A dynamic expression pattern is also observed in the central area of the larval brain. (Simon et al., 1998) In pupae of 21hrs APF to 42hrs APF, drl is detectable in discrete regions of the antennal lobe, with strong expression in the lateral-ventral portion of the anterior antennal lobe, and only in the dorso-lateral region of the posterior antennal lobe. (Sakurai et al., 2009)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015380    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015380 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015380 expression level Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr    3397 embryo 06-08hr    5819 embryo 08-10hr    6473 embryo 10-12hr    5378 embryo 12-14hr    6271 embryo 14-16hr    3583 embryo 16-18hr    2087 embryo 18-20hr    1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9    1532 white prepupae new    1640 white prepupae 12hr    1491 white prepupae 24hr    2705 pupae 2d postWPP    2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr  (1105) embryo 04-06hr  (3397) embryo 06-08hr  (5819) embryo 08-10hr  (6473) embryo 10-12hr  (5378) embryo 12-14hr  (6271) embryo 14-16hr  (3583) embryo 16-18hr  (2087) embryo 18-20hr  (1547) embryo 20-22hr  (874) embryo 22-24hr  (1094) larva L1  (663) larva L2  (179) larva L3 12hr old  (109) larva L3 puffstage 1-2  (453) larva L3 puffstage 3-6  (973) larva L3 puffstage 7-9  (1532) white prepupae new  (1640) white prepupae 12hr  (1491) white prepupae 24hr  (2705) pupae 2d postWPP  (2349) pupae 3d postWPP  (875) pupae 4d postWPP  (490) adult male 01day  (248) adult male 05day  (279) adult male 30day  (233) adult female 01day  (162) adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr  (3397) embryo 06-08hr  (5819) embryo 08-10hr  (6473) embryo 10-12hr  (5378) embryo 12-14hr  (6271) embryo 14-16hr  (3583) embryo 16-18hr  (2087) embryo 18-20hr  (1547) embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9  (1532) white prepupae new  (1640) white prepupae 12hr  1491 white prepupae 24hr  (2705) pupae 2d postWPP  (2349) pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr    3397 embryo 06-08hr    5819 embryo 08-10hr    6473 embryo 10-12hr    5378 embryo 12-14hr    6271 embryo 14-16hr    3583 embryo 16-18hr    2087 embryo 18-20hr    1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9    1532 white prepupae new    1640 white prepupae 12hr    1491 white prepupae 24hr    2705 pupae 2d postWPP    2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr    3397 embryo 06-08hr    5819 embryo 08-10hr    6473 embryo 10-12hr    5378 embryo 12-14hr    6271 embryo 14-16hr    3583 embryo 16-18hr    2087 embryo 18-20hr    1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9    1532 white prepupae new    1640 white prepupae 12hr    1491 white prepupae 24hr    2705 pupae 2d postWPP    2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015380 expression level Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr    3397 embryo 06-08hr    5819 embryo 08-10hr    6473 embryo 10-12hr    5378 embryo 12-14hr    6271 embryo 14-16hr    3583 embryo 16-18hr    2087 embryo 18-20hr    1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9    1532 white prepupae new    1640 white prepupae 12hr    1491 white prepupae 24hr    2705 pupae 2d postWPP    2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr  (1105) embryo 04-06hr  (3397) embryo 06-08hr  (5819) embryo 08-10hr  (6473) embryo 10-12hr  (5378) embryo 12-14hr  (6271) embryo 14-16hr  (3583) embryo 16-18hr  (2087) embryo 18-20hr  (1547) embryo 20-22hr  (874) embryo 22-24hr  (1094) larva L1  (663) larva L2  (179) larva L3 12hr old  109 larva L3 puffstage 1-2  (453) larva L3 puffstage 3-6  (973) larva L3 puffstage 7-9  (1532) white prepupae new  (1640) white prepupae 12hr  (1491) white prepupae 24hr  (2705) pupae 2d postWPP  (2349) pupae 3d postWPP  (875) pupae 4d postWPP  (490) adult male 01day  (248) adult male 05day  (279) adult male 30day  (233) adult female 01day  (162) adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr  (3397) embryo 06-08hr  (5819) embryo 08-10hr  (6473) embryo 10-12hr  (5378) embryo 12-14hr  (6271) embryo 14-16hr  (3583) embryo 16-18hr  2087 embryo 18-20hr  1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9  1532 white prepupae new  1640 white prepupae 12hr  1491 white prepupae 24hr  (2705) pupae 2d postWPP  2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr    3397 embryo 06-08hr    5819 embryo 08-10hr    6473 embryo 10-12hr    5378 embryo 12-14hr    6271 embryo 14-16hr    3583 embryo 16-18hr    2087 embryo 18-20hr    1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9    1532 white prepupae new    1640 white prepupae 12hr    1491 white prepupae 24hr    2705 pupae 2d postWPP    2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    77 embryo 02-04hr    1105 embryo 04-06hr    3397 embryo 06-08hr    5819 embryo 08-10hr    6473 embryo 10-12hr    5378 embryo 12-14hr    6271 embryo 14-16hr    3583 embryo 16-18hr    2087 embryo 18-20hr    1547 embryo 20-22hr    874 embryo 22-24hr    1094 larva L1    663 larva L2    179 larva L3 12hr old    109 larva L3 puffstage 1-2    453 larva L3 puffstage 3-6    973 larva L3 puffstage 7-9    1532 white prepupae new    1640 white prepupae 12hr    1491 white prepupae 24hr    2705 pupae 2d postWPP    2349 pupae 3d postWPP    875 pupae 4d postWPP    490 adult male 01day    248 adult male 05day    279 adult male 30day    233 adult female 01day    162 adult female 05day    58 adult female 30day    49 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015380    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015380 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015380 expression level Tissue   Expression Level Larval Central Nervous System    726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (726.1) Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015380 expression level Tissue   Expression Level Larval Central Nervous System    726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    726.1 Larval Midgut    10.3 Larval Hindgut    9.1 Larval Malpighian Tubules    50.2 Larval Fat Body    8.3 Larval Salivary Gland    9.2 Larval Trachea    339.725 Larval Carcass    50.8 Adult Head    109.8 Adult Eye    99.925 Adult Brain    411.5 Adult Thoracic-Abdominal Ganglion    427 Adult Crop    117.4 Adult Midgut    33.1 Adult Hindgut    23.9 Adult Malpighian Tubules    31.7 Adult Fat Body no informative data Adult Salivary Gland    37.3 Adult Heart    19.3 Adult VirginFemale Spermatheca    17.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    12.6 Adult Testis    8.4 Adult Male Accessory Gland    37.6 Adult Carcass    23.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    109.8   NA  Eye    99.925   NA  Brain    411.5   726.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    427   NA  Crop    117.4   10.3  Midgut    33.1   9.1  Hindgut    23.9   50.2  Malpighian Tubules    31.7   8.3  Fat Body    no informative data   9.2  Salivary Gland    37.3   NA  Heart    19.3   339.725  Trachea    NA   NA  VirginFemale Spermatheca    17.8   NA  InseminatedFemale Spermatheca    19.7   NA  Ovary    12.6   NA  Testis    8.4   NA  Male Accessory Gland    37.6   50.8  Carcass    23.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015380 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17348-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for drl Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially | pupal stage | recessive drlP456 viable drl2 drlP3.765 drlR300 drlR343 viable, with Scer\GAL4pnr-MD237 drlGD2537 drlGD14371 viable, with Scer\GAL4sca-4512 drlEP2076 Sterility Allele female fertile drlP3.765 drlR343 male fertile drlP3.765 drlR343 Other Phenotypes Allele behavior defective drlexc21 memory defective drl2 drlexc21 drlP1 drlP3.765 memory defective (with drl2) drlexc21 memory defective (with drlexc21) drl2 memory defective | recessive drl2 neuroanatomy defective drlR343 neuroanatomy defective, with Scer\GAL4ap-md52 drlScer\UAS.cCa neurophysiology defective, with Scer\GAL4eg-Mz360 drlScer\UAS.cCa uncoordinated (with drlP3.765) drlR343 uncoordinated (with drlR343) drlP3.765 uncoordinated | recessive drlP3.765 visible, with Scer\GAL4pnr-MD237 drlGD2537 wild-type drlap.ME4 drlK371A.ap.ME4 drlR193 Phenotype manifest in Allele A1-7 lateral transverse muscle 1 drlR343 A1-7 lateral transverse muscle 2 drlR343 A1-7 lateral transverse muscle 3 drlR343 abdominal 1 lateral transverse muscle 1 drlR300 drlR343 abdominal 1 lateral transverse muscle 2 drlR300 drlR343 abdominal 1 lateral transverse muscle 3 drlR300 drlR343 abdominal 2 lateral transverse muscle 1 drlR300 drlR343 abdominal 2 lateral transverse muscle 2 drlR300 drlR343 abdominal 2 lateral transverse muscle 3 drlR300 drlR343 abdominal 3 lateral transverse muscle 1 drlR300 drlR343 abdominal 3 lateral transverse muscle 2 drlR300 drlR343 abdominal 3 lateral transverse muscle 3 drlR300 drlR343 abdominal 4 lateral transverse muscle 1 drlR300 drlR343 abdominal 4 lateral transverse muscle 2 drlR300 drlR343 abdominal 4 lateral transverse muscle 3 drlR300 drlR343 abdominal 5 lateral transverse muscle 1 drlR300 drlR343 abdominal 5 lateral transverse muscle 2 drlR300 drlR343 abdominal 5 lateral transverse muscle 3 drlR300 drlR343 abdominal 6 lateral transverse muscle 1 drlR300 drlR343 abdominal 6 lateral transverse muscle 2 drlR300 drlR343 abdominal 6 lateral transverse muscle 3 drlR300 drlR343 abdominal 7 lateral transverse muscle 1 drlR300 drlR343 abdominal 7 lateral transverse muscle 2 drlR300 drlR343 abdominal 7 lateral transverse muscle 3 drlR300 drlR343 adult brain drlP1 adult central complex drl2 drlP3.765 drlPGAL8 drlR343 antennal lobe drlR343 antennal lobe glomerulus DA1 drlR343 antennal lobe glomerulus VA1 drlR343 anterior commissure drlR343 drlRed2 axon | embryonic stage drlP3.765 chaeta | supernumerary, with Scer\GAL4pnr-MD237 drlGD2537 ellipsoid body drl2 embryonic/larval brain drl2 embryonic/larval somatic muscle drlR343 embryonic ventral nervous system, with Scer\GAL4ap-md52 drlScer\UAS.cCa fan-shaped body drl2 drlP1 drlP3.765 drlR343 glomerulus drlR343 interneuron, with Scer\GAL4eg-Mz360 drlScer\UAS.cCa lobe system of mushroom body (with drl2) drlR343 lobe system of mushroom body (with drlR343) drl2 longitudinal connective, with Scer\GAL4sca-4512 drlEP2076 mushroom body drl2 drlP1 drlP3.765 drlPGAL8 drlR343 mushroom body (with drl2) drlexc21 mushroom body (with drlexc21) drl2 mushroom body alpha-lobe drl2 drlP1 drlP3.765 drlR343 mushroom body beta'-lobe drlP1 mushroom body beta-lobe drl2 drlP1 drlP3.765 mushroom body gamma-lobe drl2 mushroom body pedunculus drl2 drlR343 olfactory receptor neuron drlR343 optic lobe drl2 drlR343 perikaryon drl2 drlP1 posterior commissure, with Scer\GAL4eg-Mz360 drlK371A.Scer\UAS drlScer\UAS.cCa presumptive embryonic/larval central nervous system drlexc21 presumptive embryonic salivary gland drlR343 protocerebral bridge drl2 drlR343 protocerebrum | dorsal drl2 pupa drlP456 ring neuron drl2 ventral nerve cord drlR343 ventral nerve cord commissure drlR343 ventral nerve cord commissure, with Scer\GAL4sca-4512 drlEP2076
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of drl Class Mutagen Stocks Known lesion drl2 Delta2-3 2 Yes drlPGAL8 Delta2-3 2 Yes drle00040 piggyBac transposase 1 -- drle00385 piggyBac transposase 1 -- drlexc21 loss of function allele Delta2-3 1 Yes drlf04238 piggyBac transposase 1 -- drlP1 P-element activity 1 Yes drlR300 amorphic allele - genetic evidence Delta2-3 0 Yes drlR343 amorphic allele - genetic evidence P-element activity Delta2-3 0 Yes drlEP2076 P-element activity 0 Yes drlEP41 P-element activity 0 Yes drlexc22 P-element activity 0 Yes drlexc2 P-element activity 0 Yes drlexc8 P-element activity 0 Yes drli Delta2-3 0 -- drlP3.765 P-element activity 0 Yes drlP423.24 P-element activity 0 Yes drlP456 P-element activity 0 Yes drlR193 P-element activity 0 Yes drlRed2 loss of function allele P-element activity 0 -- drlunspecified 0 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of drl Class Mutagen Stocks Known lesion drlGD2537 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes drlGD14371 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes drlJF03281 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes drlKK103109 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes drlScer\UAS.cCa in vitro construct - regulatory fusion 1 Yes drlap.ME4 in vitro construct - regulatory fusion 0 Yes drlGD41 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes drlK371A.ap.ME4 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes drlK371A.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes drlP423 in vitro construct - genomic fragment 0 Yes drltMa in vitro construct - genomic fragment 0 Yes drltP456 in vitro construct - genomic fragment 0 Yes drlΔE.Scer\UAS in vitro construct - regulatory fusion 0 Yes drlΔi.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes drlΔintra.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6043 (Ryder, 2004.4.26) Df(2R)lio2 (Dura et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD41} NA P{GD2537} NA P{GD14371} NA P{KK103109} NA P{TRiP.JF03281} NA P{UAS-drl.K371A} NA P{UAS-drl.ΔE} NA P{UAS-drl.Δi.MYC} NA P{UAS-drl.Δintra} NA P{UAS-drl} NA reporter construct P{PX421} No P{PX423} No P{PX425} No P{PX432} No P{PZ442} No characterization construct P{drl.P423} NA P{drl.P456} NA P{drltMa} NA P{drl-tau-lacZ.Q} NA P{drl-tau-lacZ.R} NA P{drl-tau-lacZ.T} NA P{drl-tau-myc.E} NA P{drl-tau-myc.F} NA P{drl-tau-myc.S} NA P{drl-tau-myc.U} NA P{drl-tau-myc.W} NA P{drl-tau-myc.Y} NA P{drl-tau-myc.Z} NA P{ME4-drl.K371A} NA P{ME4-drl} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}drlEP41 NA P{EP}drlEP2076 NA P{EP}EP2129 NA miscellaneous insertions P{3'etau-lacZ}drlR343 NA P{drl.P423}drlP423.24 NA P{drl.P423-Δexc22}drlexc22 NA P{drl.P456}drlP456 NA P{lacW-Δexc2}drlexc2 NA P{lacW-Δexc8}drlexc8 NA P{PTT-GC}CC00251 NA P{UAS-drl}i NA PBac{RB}drle00040 NA PBac{RB}drle00385 NA PBac{WH}drlf04238 NA insertion of enhancer trap P{etau-lacZ}drlP3.765 No P{etau-lacZ}drlRed2 No P{lacW}l(2)SH2023SH2023 No P{lacW}pigeonP1 No insertion of enhancer trap binary system P{GawB}drlPGAL8 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
Wnt-protein binding inferred from physical interaction with Wnt5 (Yoshikawa et al., 2003)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (assigned by UniProtKB) (Callahan et al., 1995) axon midline choice point recognition inferred from mutant phenotype (Yoshikawa et al., 2003) haltere development inferred from genetic interaction with Ubx (Pallavi et al., 2006) learning or memory inferred from mutant phenotype (assigned by UniProtKB) (Dura et al., 1995) memory inferred from mutant phenotype (Moreau-Fauvarque et al., 2002) muscle attachment inferred from mutant phenotype (Callahan et al., 1996) olfactory learning inferred from mutant phenotype (Moreau-Fauvarque et al., 2002) salivary gland morphogenesis inferred from mutant phenotype (Harris and Beckendorf, 2007) signal transduction inferred from mutant phenotype (assigned by UniProtKB) (Callahan et al., 1995)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity inferred from electronic annotation with InterPro:IPR003306, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) non-traceable author statement (Callahan, 1995.9.13, Taillebourg, 1995.9.19, Morrison et al., 2000) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity (assigned by UniProtKB) (Callahan et al., 1995) non-traceable author statement (Roman and Davis, 2001)
Biological Process
CV term Evidence References
olfactory learning traceable author statement (Roman and Davis, 2001) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
plasma membrane inferred from sequence or structural similarity (assigned by UniProtKB) (Callahan et al., 1995)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions drl allele Gene References drl2 cas (Hitier et al., 2001) drlP1 cas (Hitier et al., 2001) drlP3.765 cas (Hitier et al., 2001) Nrt (Speicher et al., 1998) drlR343 dnt (Oates et al., 1998) drlRed2 Wnt5 (Yoshikawa et al., 2003) drlScer\UAS.cCa Wnt5 (Yoshikawa et al., 2003) unspecified Ubx (Pallavi et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69001 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015380 DroID - A comprehensive database of gene and protein interactions. • FBgn0015380 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44355
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14710 Dere\GG21167 Dgri\GH13441 Dmoj\GI14000 Dper\GL21194 Dpse\GA14473 Dsec\GM17332 Dsim\GD24191 Dvir\GJ18248 Dwil\GK23825 Dyak\GE13238
Curated drosophilid orthologs	Dpse\GA14473
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CN25642 Caenorhabditis brenneri (small nematode) CE27692 Caenorhabditis elegans (worm) JA17043 Caenorhabditis japonica (nematode) 166395 Chlamidomonas reinhardtii (green alga) RP45402 Caenorhabditis remanei (nematode) 188920 Capitella spl (polychaete worm) 194312 Hypsipyla robusta (cedar shoot borer) ISCW009358-PA Ixodes scapularis (deer tick) 213735 Lottia gigantea (owl limpet) 27123 Monocosta brevicollis (choanoflagellate) XP_001606015.1 Nasonia vitripennis (wasp) PP22277 Pristionchus pacificus (nematode) ENSTNIP00000021849 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000042395 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230929 FBgn0225787 FBgn0205409 FBgn0195542 FBgn0172242 FBgn0074501 FBgn0158787 FBgn0136754 FBgn0120917 FBgn0113348 FBgn0091737
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	8812 w*; P{UAS-drl}3 7363 w1118; drlexc21/CyO 4669 w1118; P{GawB}drlPGAL8 29602 y1 v1; P{TRiP.JF03281}attP2
Harvard	- PBac{RB}drle00040 - PBac{RB}drle00385 - PBac{WH}drlf04238
Kyoto	107831 w1118; P{GawB}drlPGAL8
VDRC	v100039 P{KK103109}VIE-260B v3047 w1118; P{GD2537}v3047 v3048 w1118; P{GD2537}v3048 v27053 w1118; P{GD14371}v27053
	More stocks available...
Genomic Clones ( 2 )
	BACR10I09 BACR48O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35237
Other clones	DPiM_LD35237
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02640 AT26693 AT27208 HL01335 LD43616 LP15417 RE08175 RE16441 RE29180 RE30285 RE31426 RE43482 RE44340 RE45978 RE46428 RE49210 RE50476 RE51110 RE52262 RE57169 RH01706 RH04716 RH06587 RH42564 RH49593 RH58218 RH59266 RH63381 RH73240 RH74242
Other clones	11419 43546 66484 73479 75332 79673 97206 100187 108685 121500 147847 214467.26 CK01.125B.D6 CK01.133A.C8 EC051311 EC052334 EC053335 EC056541 EK096036 EK100031 EK109202 EK111660 EK162740 EK177950 EK194335 EK202938 EK207236 EK209815 EK219438 EK223061 EK241653 EK245050 EK251518 EK251602 EK255701 Parral_28_E04 RH01413
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015380 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44355
Antibody Information
	polyclonal (Callahan et al., 1995)
Other Information
Discoverer
Etymology
	In French someone who forgets everything is said to be a "tete de linotte," the equivalent of bird-brain in English. (Dura et al., 1993)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: drl CG10758 CG17348 (Bayraktaroglu, 2000.4.17)
Additional comments	Release 1 annotation CG10758 corresponds to part of the release 3.2 annotation for drl (CG17348). (FlyBase, 1996-) The gene described as 'lio' in FBrf0083123 is drl (FBgn0015380), as is made clear by comparison of molecular maps in FBrf0083123 and FBrf0083785. (Dura et al., 1995) FlyBase curator comment: pigeon and drl are neighboring genes, pigeon being 5' and distal to drl. Confusingly, both pigeon and drl have been referred to as 'lio' in the literature. e.g. the gene described as 'lio' in FBrf0083123 is drl (FBgn0015380), the gene described as 'lio' in FBrf0083785 is pigeon (FBgn0010309).
Other Comments
	drl and Wnt5 are required (in the salivary gland and in the central nervous system respectively) for normal salivary gland migration in the embryo. They are required in the third phase of migration, to mediate the final positioning of the gland, as the salivary gland detaches from the circular visceral mesoderm and contacts the longitudinal visceral mesoderm. (Harris and Beckendorf, 2007) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in cytokinetic index is seen. (Bettencourt-Dias et al., 2004) drl is essential for Wnt (Wnt5) mediated axon guidance. (Yoshikawa et al., 2003) Mutation of drl causes behavioral defects independently of pigeon. (Moreau-Fauvarque et al., 2002) The memory phenotype of drl mutants appears to be a consequence of abnormal brain development due to loss of function of the drl receptor tyrosine kinase. (Moreau-Fauvarque et al., 2002) A predicted kinase-deficient drl transgene retains drl function in two separate assays, suggesting that drl does not require kinase activity in vivo. (Yoshikawa et al., 2001) Expression of drl in each of four subclasses of anterior commissural neurons is controlled by separate transcriptional regulatory sequences. (Bonkowsky and Thomas, 1999) drl acts as a guidance receptor for a repellent ligand present in the posterior commissure in the developing embryonic nervous system. (Bonkowsky et al., 1999) P-element transformation vectors containing drl regulatory sequences show insertion site homing capability. (Taillebourg and Dura, 1999) drl mutants show structural brain defects in the adult central complex and mushroom bodies. (Moreau-Fauvarque et al., 1998) Loss of drl function is responsible for ventral attachment defects, muscle phenotype can be rescued by expression of a drl cDNA. (Callahan et al., 1996) Neurons and muscles use common mechanisms to recognise their paths or targets. drl plays an analogous role in both developing systems. (Callahan et al., 1996) drl maps 70kb proximal to Ddc. (Callahan et al., 1995) drl plays a key controlling role in the multiple discrete steps of neuronal pathway recognition. Results predict that once activated by its ligand drl controls pathway selection by modulating the function of specific cell adhesion molecules that mediate proper axon fasciculation. (Callahan et al., 1995) The drl gene product may be part of an atypical signal transduction cascade involved in the development of the adult brain. (Dura et al., 1995) Behaviour-genetic data suggests that 'lio' is non-vital. (Dura et al., 1993) 'lio' is involved with learning and memory. (Dura et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057791 RefSeq (Proteins) • NP_477139 DDBJ / EMBL / GenBank • AAA75347 AAA79949 AAD41343 AAF53776 AAK93276 AC005440 AC007176 AF147883 AI518833 AQ074081 AW943271 AY051852 CZ477951 CZ478279 CZ486769 L47260 U36584 Entrez Gene - A searchable database of RefSeq genes. • 44355 UniProtKB/Swiss-Prot • Q27324
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) WIF domain (IPR003306) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69001 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015380 DroID - A comprehensive database of gene and protein interactions. • FBgn0015380 DRSC - Results from RNAi screens. • FBgn0015380 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015380 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17348-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015380 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44355 InParanoid A subset of ortholog calls from InParanoid. • CN25642 Caenorhabditis brenneri (small nematode) CE27692 Caenorhabditis elegans (worm) JA17043 Caenorhabditis japonica (nematode) 166395 Chlamidomonas reinhardtii (green alga) RP45402 Caenorhabditis remanei (nematode) 188920 Capitella spl (polychaete worm) 194312 Hypsipyla robusta (cedar shoot borer) ISCW009358-PA Ixodes scapularis (deer tick) 213735 Lottia gigantea (owl limpet) 27123 Monocosta brevicollis (choanoflagellate) XP_001606015.1 Nasonia vitripennis (wasp) PP22277 Pristionchus pacificus (nematode) ENSTNIP00000021849 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000042395 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/derail1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44355 modMine - Data generated by the modENCODE project. • FBgn0015380 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230929 FBgn0225787 FBgn0205409 FBgn0195542 FBgn0172242 FBgn0074501 FBgn0158787 FBgn0136754 FBgn0120917 FBgn0113348 FBgn0091737 REDfly - A database of transcriptional regulatory elements. • FBgn0015380
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG10758 (Roos, 2000.4.14, ) CG17348 (Morrison et al., 2000, Roos, 2000.4.14, Keleman et al., 2009.8.5, Perkins et al., 2009) derailed (Edwards et al., 2006) DRL (Prokopenko and Thomas, 2002, Katsuki et al., 2009) drl (Jordan et al., 2006, Pallavi et al., 2006, Bovolenta et al., 2006, Liebl et al., 2008, Buszczak et al., 2007, Dietzl et al., 2007, Brodsky et al., 2004, Yao et al., 2007, Harris and Beckendorf, 2007, Sandmann et al., 2006, Grillenzoni et al., 2007, Allen and Spradling, 2008, Wouda et al., 2008, Xia and Tully, 2007, Chen and Condron, 2008, Ayroles et al., 2009, Krejcí et al., 2009, Sakurai et al., 2009, Hall, 2003, Zlatic et al., 2009, Zeitlinger et al., 2007, Singh et al., 2010) Drl (Chilton, 2006) lin (Roman and Davis, 2001) lio (Pallavi and Shashidhara, 2003, Whitfield et al., 2002, Morley and Montgomery, 2001, Moreau-Fauvarque et al., 2002, Waddell and Quinn, 2001, Hitier et al., 2001, Hitier et al., 2000, Taillebourg, 1995.9.19, Preat et al., 1999, Taillebourg and Dura, 1999, Dura et al., 1999, Moreau-Fauvarque et al., 1998, Simon et al., 1997, Moreau et al., 1997, Simon et al., 1998, Simon et al., 1997, Moreau et al., 1997, Dura et al., 1995, Dura et al., 1995, Dura et al., 1993, van Swinderen, 2007, Acevedo et al., 2007, Grillenzoni et al., 2007, Dura et al., 2007, Hall, 2003) lio/drl (Taillebourg and Dura, 2000) unnamed (Bolwig et al., 1995)
Name Synonym	derailed (Edwards et al., 2006, Callahan, 1995.9.13, Jordan et al., 2006, Pallavi et al., 2006, Chilton, 2006, Yao et al., 2007, Harris and Beckendorf, 2007, Wouda et al., 2008, Chen and Condron, 2008, Krejcí et al., 2009, Hall, 2003) Derailed (Clevers, 2006, Gordon and Nusse, 2006, Bovolenta et al., 2006, Liebl et al., 2008) linotte (Ringrose et al., 2003, Shapiro, 1999, Dura and Taillebourg, 1999, Moreau et al., 1998, Hitier et al., 2000, Moreau et al., 1997, Dura et al., 1995, Tully and Xia, 2006, Dura et al., 2007, Hall, 2003) lionette (Pallavi and Shashidhara, 2003)
Secondary FlyBase IDs
	FBgn0032764 FBgn0032765
References ( 144 )
Generate a list of	All references relating to this gene ( 144 )
List References by type	Research paper  ( 64 ) Supplementary material  ( 7 ) Review  ( 31 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 23 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Singh et al., 2010, Development 137(8): 1351--1360 Dendritic refinement of an identified neuron in the Drosophila CNS is regulated by neuronal activity and Wnt signaling. [FBrf0210379] Show all research papers ...
Recent reviews ( 1 )
	Fradkin et al., 2010, Trends Neurosci. 33(2): 84--92 Ryks: new partners for Wnts in the developing and regenerating nervous system. [FBrf0212856] Show all reviews ...