FlyBase Gene Report: Dmel\drl

General Information

Symbol

Dmel\drl

Species

D. melanogaster

Name

derailed

Annotation Symbol

CG17348

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015380

Gene Model Status

Stock Availability

20 publicly available

Gene Summary

derailed (drl) encodes an atypical receptor tyrosine kinase with the product of Wnt5 as a ligand. It controls axon guidance events during neural development. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

lio, linotte

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:19,190,342..19,208,621 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:19190342..19208621

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (30 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

enables protein heterodimerization activity

inferred from physical interaction with FLYBASE:dnt; FB:FBgn0024245

(Petrova et al., 2013)

inferred from physical interaction with FLYBASE:Drl-2; FB:FBgn0033791

(Petrova et al., 2013)

enables protein homodimerization activity

inferred from physical interaction with FLYBASE:drl; FB:FBgn0015380

(Petrova et al., 2013)

enables protein kinase binding

inferred from physical interaction with FLYBASE:Src64B; FB:FBgn0262733

(Petrova et al., 2013)

enables Wnt-activated receptor activity

inferred from direct assay

(Petrova et al., 2013)

enables Wnt-protein binding

inferred from physical interaction with FLYBASE:Wnt5; FB:FBgn0010194

(Yoshikawa et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables Wnt-activated receptor activity

traceable author statement

(assigned by ParkinsonsUK-UCL )

(Fradkin et al., 2010)

NOT enables protein tyrosine kinase activity

inferred from key residues

(Halford and Stacker, 2001)

Biological Process (19 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(assigned by UniProt )

(Callahan et al., 1995)

inferred from mutant phenotype

(Yao et al., 2007)

involved_in axon midline choice point recognition

inferred from mutant phenotype

(Yoshikawa et al., 2003)

involved_in chemorepulsion of axon

inferred from mutant phenotype

(Reynaud et al., 2015)

inferred from genetic interaction with FLYBASE:Wnt5; FB:FBgn0010194

(Yoshikawa et al., 2003)

involved_in dendrite guidance

inferred from mutant phenotype

(Wu et al., 2014, Yao et al., 2007)

involved_in determination of muscle attachment site

inferred from mutant phenotype

(Lahaye et al., 2012)

involved_in haltere development

inferred from genetic interaction with FLYBASE:Ubx; FB:FBgn0003944

(Pallavi et al., 2006)

involved_in learning or memory

inferred from mutant phenotype

(assigned by UniProt )

(Dura et al., 1995)

involved_in memory

inferred from mutant phenotype

(Moreau-Fauvarque et al., 2002)

involved_in muscle attachment

inferred from mutant phenotype

(Callahan et al., 1996)

involved_in olfactory learning

inferred from mutant phenotype

(Moreau-Fauvarque et al., 2002)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Harris and Beckendorf, 2007)

involved_in signal transduction

inferred from mutant phenotype

(assigned by UniProt )

(Callahan et al., 1995)

Terms Based on Predictions or Assertions (9 terms)

CV Term

Evidence

References

involved_in axon guidance

traceable author statement

(assigned by ParkinsonsUK-UCL )

(Fradkin et al., 2010)

involved_in axonogenesis

inferred from biological aspect of ancestor with PANTHER:PTN002521291

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cell-cell signaling by wnt

traceable author statement

(assigned by ParkinsonsUK-UCL )

(Fradkin et al., 2010)

involved_in mushroom body development

traceable author statement

(assigned by ParkinsonsUK-UCL )

(Fradkin et al., 2010)

involved_in olfactory learning

traceable author statement

(Roman and Davis, 2001)

involved_in positive regulation of kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein phosphorylation

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in synapse assembly

traceable author statement

(assigned by ParkinsonsUK-UCL )

(Fradkin et al., 2010)

involved_in transmembrane receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Katsuki et al., 2009)

located_in dendrite

inferred from direct assay

(Yao et al., 2007)

located_in integral component of plasma membrane

inferred from direct assay

(Petrova et al., 2013)

part_of receptor complex

inferred from direct assay

(Petrova et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PUTATIVE PSEUDOKINASES

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. (Q27324)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

derailed (drl) encodes an atypical receptor tyrosine kinase with the product of Wnt5 as a ligand. It controls axon guidance events during neural development. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

PUTATIVE PSEUDOKINASES -: Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).
RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Protein Function (UniProtKB)

Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.

(UniProt, Q27324)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\drl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q27324)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0081195

3104

610

FBtr0330209

3104

645

Additional Transcript Data and Comments

Reported size (kB)

3.1 (longest cDNA)

(Callahan et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0080736

68.3

610

6.06

FBpp0303242

72.4

645

6.90

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

610 (aa)

(Callahan et al., 1995)

Comments

External Data

Domain

The extracellular WIF domain is responsible for Wnt binding.

(UniProt, Q27324)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drl using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Callahan et al., 1995)

larval anterior commissure

(Wouda et al., 2008)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

(Fisher et al., 2012)

(Fisher et al., 2012)

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11

embryonic primordium of adult salivary gland | dorsal | posterior

(Harris and Beckendorf, 2007)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

stomatogastric nervous system primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 12

visual primordium | restricted

(Biehs et al., 2010)

embryonic stage 13 -- 16

muscle cell of abdominal 2 lateral transverse muscle 1 -- muscle cell of abdominal 7 lateral transverse muscle 1

Comment: reference states 10-14 hr AEL

(Callahan et al., 1996)

muscle cell of abdominal 2 lateral transverse muscle 2 -- muscle cell of abdominal 7 lateral transverse muscle 2

Comment: reference states 10-14 hr AEL

(Callahan et al., 1996)

muscle cell of abdominal 2 lateral transverse muscle 3 -- muscle cell of abdominal 7 lateral transverse muscle 3

Comment: reference states 10-14 hr AEL

(Callahan et al., 1996)

embryonic brain

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic stomatogastric nervous system

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval midgut interstitial cell

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

embryonic/larval somatic muscle cell

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 14

larval ventral nerve cord | restricted

Comment: anterior part of each segment

(Wouda et al., 2008)

Additional Descriptive Data

In stage 12 embryos, drl is expressed in the posterior lobe but not in the anterior lobe of the optic primordium.

(Biehs et al., 2010)

drl is expressed in neuronal cell bodies that send projections to the anterior commissure.

(Wouda et al., 2008)

drl RNA expression initiates at stage 11 in the

(Harris and Beckendorf, 2007)

dorsoposterior portion of the salivary placodes, encompassing the initial site of invagination and thus the cells that will later form the distal tip of the salivary gland.

(Harris and Beckendorf, 2007)

drl transcripts are expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. They are enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and are no longer detected by hour 15.

(Callahan et al., 1996)

drl transcript expression is restricted to the cell bodies of a cluster of about 20 interneurons per hemisegment. Expression commences postmitotically in the neurons as they begin elongating axons and continues throughout embryogenesis.

(Callahan et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval anterior commissure

(Callahan et al., 1995)

(Callahan et al., 1995)

embryonic stage 11 -- 15

epidermis | restricted

Comment: 6-14 hr AEL

(Callahan et al., 1996)

embryonic stage 13 -- 16

muscle cell of abdominal 2 lateral transverse muscle 1 -- muscle cell of abdominal 7 lateral transverse muscle 1

Comment: reference states 10-14 hr AEL

(Callahan et al., 1996)

muscle cell of abdominal 2 lateral transverse muscle 2 -- muscle cell of abdominal 7 lateral transverse muscle 2

Comment: reference states 10-14 hr AEL

(Callahan et al., 1996)

muscle cell of abdominal 2 lateral transverse muscle 3 -- muscle cell of abdominal 7 lateral transverse muscle 3

Comment: reference states 10-14 hr AEL

(Callahan et al., 1996)

embryonic stage 16

symmetrical commissure | subset of embryonic/larval brain

(Grillenzoni et al., 2007)

Comment: 16h APF

(Wu et al., 2014)

antennal lobe projection neuron | subset

• dendrite

Comment: 16h APF

(Wu et al., 2014)

protocerebrum | restricted

Comment: 24 APF

(Reynaud et al., 2015)

pupal stage P6 -- P7

antennal lobe | restricted

(Sakurai et al., 2009)

pupal stage P6 -- pharate adult stage P9

adult antennal lobe projection neuron

(Yao et al., 2007)

adult antennal lobe glomerulus | restricted

(Yao et al., 2007)

antennal lobe glomerulus DA1

(Sakurai et al., 2009)

pharate adult stage P8

adult mushroom body beta-lobe | restricted

Comment: 48 APF

(Reynaud et al., 2015)

adult mushroom body alpha-lobe | restricted

Comment: 48 APF

(Reynaud et al., 2015)

Additional Descriptive Data

drl-protein is expressed in six large groups of cells in the dorsomedial part of the third instar larval brain. At 24 APF drl-protein is detected in cells of the protocerebrum surrounding the mushroom body. At 48 APF the extracellular domain of drl can be detected at the tips of mushroom body lobes alpha and beta. Higher levels are detected at the tip of alpha lobes compared to beta lobes.

(Reynaud et al., 2015)

drl-protein is detected at 16h APF throughout the developing antennal lobes with high concentrations in the dorsolateral region. drl-protein is co-expressed with Scer\GAL4^GH146 and Wnt5-protein in dendrites of a subset of antennal lobe projection neurons.

(Wu et al., 2014)

In pupae of 21hrs APF to 42hrs APF, drl is detectable in discrete regions of the antennal lobe, with strong expression in the lateral-ventral portion of the anterior antennal lobe, and only in the dorso-lateral region of the posterior antennal lobe.

(Sakurai et al., 2009)

In the late embryonic brain, two commissural tracts express drl protein; these tracts do not co-express Fas3, and the axonal growth cones of embryonic Kenyon cells are closesly apposed to them. In the third instar larval brain, drl protein is expressed in a complex pattern characterized by a lack of colocalization with with Fas2-positive mushroom body axons. Expression is observed in four glial cells, located in the posterior part of the larval brain, whose processes wrap around the mushroom body lobes. drl immunoreactivity is also observed in brain commissures, in the optic lobe and incoming photoreceptor axons, and in commissural neurons of the thoracico-abdominal ganglion.

(Grillenzoni et al., 2007)

drl protein was localized to projection neuron dendrites during glomerular development and was found to function in glial cells.

(Yao et al., 2007)

drl protein is first detected in larvae at the early third instar stage and increases until pupation. It is then detected in the optic lobe anlage and in the interhemispheric area, near the commissure. A dynamic expression pattern is also observed in the central area of the larval brain.

(Simon et al., 1998)

drl protein is detected in the epidermis and mesoderm during embyogenesis. It is expressed in lateral transverse muscles 1-3 in abdominal segments A2 through A7 as they grow and form attachments to the epidermis. It is first detected at hour 10 of development, is enriched at the tips of the muscles where they will form their ventral attachments at hour 13, and is no longer detected by hour 15. drl protein is detected in the epidermis starting at hour 6 in stripes 3-4 cells wide in each segment. It is restricted to the anterior of eac segment during segmental groove formation and then at hour 9.5 expands posteriorly from the grooves, resulting in patches of drl-expressing cells. The patches become more refined and are positioned around the dorsal and ventral attachment sites for lateral transverse muscles 1-3.

(Callahan et al., 1996)

drl protein is localized to the growth cones and axons of the drl-expressing neurons as they cross the anterior commissure. After they have turned anteriorly, drl protein cannot be detected in the part of the axons within the connectives and is restricted to axon segments within the anterior commissure.

(Callahan et al., 1995)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Katsuki et al., 2009)

located_in dendrite

inferred from direct assay

(Yao et al., 2007)

located_in integral component of plasma membrane

inferred from direct assay

(Petrova et al., 2013)

part_of receptor complex

inferred from direct assay

(Petrova et al., 2013)

Expression Deduced from Reporters

Reporter: P{etau-lacZ}drl^P3.765

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 16

embryonic/larval salivary gland | distal

(Harris and Beckendorf, 2007)

embryonic stage 15 -- 16

multidendritic neuron

(Callahan and Thomas, 1994)

(Callahan and Thomas, 1994)

third instar larval stage

embryonic/larval optic lobe

(Simon et al., 1998)

embryonic/larval brain | restricted

(Simon et al., 1998)

embryonic/larval central nervous system | restricted

(Hitier et al., 2001)

third instar larval stage -- pupal stage

glial cell | subset

(Hitier et al., 2001)

pupal brain | restricted

(Simon et al., 1998)

Reporter: P{GawB}drl^PGAL8

Stage

Tissue/Position (including subcellular localization)

Reference

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\drl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\drl

View exonic expression by tissue for Dmel\drl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015380

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44355/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015380

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015380

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015380

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17348

Flygut - An atlas of the Drosophila adult midgut

FBgn0015380

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\drl

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 24 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 30 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of drl

Transgenic constructs containing regulatory region of drl

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

(Ryder, 2004.4.26)

(Dura et al., 1995)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage | partially | recessive

drl^P456

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

drl^GD14371

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^sca-4512

drl^EP2076

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

drl^HMS01918

Other Phenotypes

Allele

abnormal behavior

drl^exc21

abnormal learning, with Scer\GAL4^elav.PU

abnormal locomotor behavior, with Scer\GAL4^Appl.G1a

drl^JF03281

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

drl^JF03281

abnormal memory

abnormal memory (with drl²)

drl^exc21

abnormal memory (with drl^exc21)

drl²

abnormal memory | progressive

drl^P1

abnormal memory | recessive

drl²

abnormal neuroanatomy

drl^R343

abnormal neuroanatomy, with Scer\GAL4^ap-md52

drl^UAS.cCa

abnormal neuroanatomy (with drl²)

drl^R343

abnormal neuroanatomy (with drl^P1)

drl^R343

abnormal neuroanatomy (with drl^R343)

abnormal neuroanatomy | adult stage

abnormal neuroanatomy | adult stage, with Scer\GAL4^GH146

drl^UAS.cYa

abnormal neurophysiology, with Scer\GAL4^eg-Mz360

drl^UAS.cCa

some die during pupal stage | recessive

drl^P456

uncoordinated (with drl^P3.765)

drl^R343

uncoordinated (with drl^R343)

drl^P3.765

uncoordinated | recessive

drl^P3.765

visible, with Scer\GAL4^pnr-MD237

drl^GD2537

Phenotype manifest in

Allele

adult antennal lobe

drl²

adult antennal lobe projection neuron

drl²

adult antennal lobe projection neuron adPN

drl^unspecified

adult antennal lobe projection neuron adPN | somatic clone

drl^unspecified

adult antennal lobe projection neuron DL1 adPN

drl^unspecified

adult antennal lobe projection neuron DL1 adPN | somatic clone

drl^unspecified

adult antennal lobe projection neuron lPN

drl^unspecified

adult antennal lobe projection neuron lPN | somatic clone

drl^unspecified

adult antennal lobe projection neuron VA4 lPN, with Scer\GAL4^GH146

drl^UAS.cYa

adult antennal lobe projection neuron VC2 lPN, with Scer\GAL4^GH146

drl^UAS.cYa

adult antennal lobe projection neuron VM1 lPN, with Scer\GAL4^GH146

drl^UAS.cYa

adult antennal lobe projection neuron VM3 adPN, with Scer\GAL4^GH146

drl^UAS.cYa

adult antennal lobe projection neuron vPN

drl^unspecified

adult antennal lobe projection neuron vPN | somatic clone

drl^unspecified

adult antennal olfactory receptor neuron

drl²

drl^P1

adult central complex

adult ellipsoid body ring neuron

drl²

adult mushroom body

adult mushroom body (with drl²)

drl^exc21

adult mushroom body (with drl^exc21)

drl²

adult mushroom body alpha-lobe

adult mushroom body alpha-lobe (with drl²)

drl^R343

adult mushroom body alpha-lobe (with drl^R343)

drl²

adult mushroom body beta'-lobe

drl^P1

adult mushroom body beta-lobe

adult mushroom body gamma-lobe

drl²

adult optic lobe

alpha/beta Kenyon cell (with drl²)

drl^R343

alpha/beta Kenyon cell (with drl^P1)

drl^R343

alpha/beta Kenyon cell (with drl^R343)

drl^R343

antennal lobe glomerulus DA1

drl^R343

antennal lobe glomerulus VA1

drl^R343

axon | embryonic stage

drl^P3.765

chaeta | increased number, with Scer\GAL4^pnr-MD237

drl^GD2537

dendrite | adult stage, with Scer\GAL4^GH146

drl^UAS.cYa

dendrite | somatic clone

drl^unspecified

drl²

embryonic/larval brain

drl²

embryonic/larval somatic muscle cell

drl^R343

embryonic ventral nerve cord, with Scer\GAL4^ap-md52

drl^UAS.cCa

fan-shaped body

drl^R343

interneuron, with Scer\GAL4^eg-Mz360

drl^UAS.cCa

larval anterior commissure

larval longitudinal connective, with Scer\GAL4^sca-4512

drl^EP2076

larval posterior commissure, with Scer\GAL4^eg-Mz360

larval ventral nerve cord

drl^R343

larval ventral nerve cord commissure

drl^R343

larval ventral nerve cord commissure, with Scer\GAL4^sca-4512

drl^EP2076

lateral transverse muscle cell | embryonic stage 16

drl^Red2

lateral transverse muscle cell | embryonic stage 16 (with Df(2L)ED1231)

drl^Red2

lateral transverse muscle cell | embryonic stage 16 (with Df(2L)Exel6043)

drl^Red2

lateral transverse muscle cell | third instar larval stage

drl^Red2

lobe system of adult mushroom body (with drl²)

drl^R343

lobe system of adult mushroom body (with drl^R343)

drl²

muscle cell of A1-7 lateral transverse muscle 1

drl^R343

muscle cell of A1-7 lateral transverse muscle 2

drl^R343

muscle cell of A1-7 lateral transverse muscle 3

drl^R343

muscle cell of abdominal 1 lateral transverse muscle 1

muscle cell of abdominal 1 lateral transverse muscle 2

muscle cell of abdominal 1 lateral transverse muscle 3

muscle cell of abdominal 2 lateral transverse muscle 1

muscle cell of abdominal 2 lateral transverse muscle 2

muscle cell of abdominal 2 lateral transverse muscle 3

muscle cell of abdominal 3 lateral transverse muscle 1

muscle cell of abdominal 3 lateral transverse muscle 2

muscle cell of abdominal 3 lateral transverse muscle 3

muscle cell of abdominal 4 lateral transverse muscle 1

muscle cell of abdominal 4 lateral transverse muscle 2

muscle cell of abdominal 4 lateral transverse muscle 3

muscle cell of abdominal 5 lateral transverse muscle 1

muscle cell of abdominal 5 lateral transverse muscle 2

muscle cell of abdominal 5 lateral transverse muscle 3

muscle cell of abdominal 6 lateral transverse muscle 1

muscle cell of abdominal 6 lateral transverse muscle 2

muscle cell of abdominal 6 lateral transverse muscle 3

muscle cell of abdominal 7 lateral transverse muscle 1

muscle cell of abdominal 7 lateral transverse muscle 2

muscle cell of abdominal 7 lateral transverse muscle 3

mushroom body pedunculus

olfactory receptor neuron

drl^R343

presumptive embryonic/larval central nervous system

drl^exc21

presumptive embryonic salivary gland

drl^R343

protocerebral bridge

protocerebrum | dorsal

drl²

drl^P456

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (7)

7 of 13

Yes

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

Rnor\LOC102552659

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (5)

7 of 12

Yes

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (8)

12 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:ch73-383l1.1

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (3)

10 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (1)

1 of 9

Yes

No

Saccharomyces cerevisiae (Brewer's yeast) (1)

1 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (19)

Gene Symbol

Score

Source

Alignment

9 of 10

6 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

model of intellectual disability

CEA

(Chakraborty et al., 2015)

model of intellectual disability

CEA

(Chakraborty et al., 2015)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates intellectual disability

modeled by Ube3a^unspecified

(Chakraborty et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RYK; receptor like tyrosine kinase

12 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

quantitative reverse transcription pcr

(Yatsenko and Shcherbata, 2014)

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot, tox-r dimerization assay

(Petrova et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot

(Reynaud et al., 2015, Petrova et al., 2013)

pull down, Identification by mass spectrometry

(Garelli et al., 2015)

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Petrova et al., 2013, Wouda et al., 2008)

experimental knowledge based

(Guruharsha et al., 2011)

pull down, western blot, mass spectrometry study of hydrogen/deuterium exchange, Identification by mass spectrometry, surface plasmon resonance, predetermined participant, affinity technology, tag visualisation, inferred by author, anti tag coimmunoprecipitation, anti tag western blot

(Shi et al., 2021, Reynaud et al., 2015, Yoshikawa et al., 2003)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot

(Petrova et al., 2013)

experimental knowledge based, inferred by curator

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Hitier et al., 2001)

suppressible

(Oates et al., 1998)

suppressible

(Reynaud et al., 2015, Sakurai et al., 2009)

enhanceable

(Sakurai et al., 2009)

suppressible

(Sakurai et al., 2009)

enhanceable

(Harris and Beckendorf, 2007)

suppressible

(Wu et al., 2014, Yao et al., 2007, Yoshikawa et al., 2003)

enhanceable

(Wu et al., 2014, Sakurai et al., 2009, Yao et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Sakurai et al., 2009)

enhanceable

(O'Donnell and Bashaw, 2013)

enhanceable

(Harris and Beckendorf, 2007)

suppressible

(Chakraborty et al., 2015)

enhanceable

(Pallavi et al., 2006)

suppressible

(Wu et al., 2014, Yoshikawa et al., 2003)

enhanceable

(Reynaud et al., 2015, Lahaye et al., 2012)

enhanceable

(Reynaud et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69001

DroID - A comprehensive database of gene and protein interactions.

FBgn0015380

MIST (genetic) - An integrated Molecular Interaction Database

drl

MIST (protein-protein) - An integrated Molecular Interaction Database

drl

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-54

Cytogenetic map

Sequence location

2L:19,190,342..19,208,621 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

37C7-37C7

Limits computationally determined from genome sequence between P{lacW}brat^k06028&P{lacW}l(2)k09613^k09613 and P{EP}dnt^EP2158

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

37C-37C

(Callahan, 1995.9.13)

37D-37D

(determined by in situ hybridisation)

(Bolwig et al., 1995, Dura et al., 1993)

37C-37C

(determined by in situ hybridisation)

(Callahan et al., 1995)

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-53.6

(Comeron et al., 2012)

2-

(Callahan, 1995.9.13)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

64336

w¹¹¹⁸; P{UAS-drl.ΔWIF.MYC}3

7363

w¹¹¹⁸; drl^exc21/CyO

64335

P{UAS-drl.Δcyto.MYC}1, w¹¹¹⁸

64333

w¹¹¹⁸ P{UAS-drl.WT.MYC}attP18

4669

w¹¹¹⁸; P{GawB}drl^PGAL8

64334

w¹¹¹⁸; PBac{UAS-drl.WT.MYC}VK00027

29602

y¹ v¹; P{TRiP.JF03281}attP2

63928

w¹¹¹⁸; PBac{IT.GAL4}drl^0960-G4

F001706

M{UAS-drl.ORF}ZH-86Fb

107831

w¹¹¹⁸; P{GawB}drl^PGAL8

v100039

P{KK103109}VIE-260B

v3047

w¹¹¹⁸; P{GD2537}v3047

More stocks available...

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD35237

Other clones

DPiM_LD35237

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015380

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015380

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44355

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Callahan et al., 1995)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: drl CG10758 CG17348

(Bayraktaroglu, 2000.4.17)

Additional comments

Release 1 annotation CG10758 corresponds to part of the release 3.2 annotation for drl (CG17348).

(FlyBase, 1996-)

The gene described as 'lio' in FBrf0083123 is drl (FBgn0015380), as is made clear by comparison of molecular maps in FBrf0083123 and FBrf0083785.

(Dura et al., 1995)

FlyBase curator comment: pigeon and drl are neighboring genes, pigeon being 5' and distal to drl. Confusingly, both pigeon and drl have been referred to as 'lio' in the literature. e.g. the gene described as 'lio' in FBrf0083123 is drl (FBgn0015380), the gene described as 'lio' in FBrf0083785 is pigeon (FBgn0010309).

Other Comments

drl is required for mushroom body α branch axon guidance during brain development. drl protein is expressed in the dorsomedial lineages adjacent to the mushroom bodies and acts to capture and present Wnt5 protein to mushroom body axons (rather than transducing a Wnt5 signal). The drl ectodomain must be cleaved and shed to guide the α axons. Biochemical data indicates that a cleaved and shed drl extracellular domain can form a ternary complex with Wnt5 and Drl-2, providing a mechanism by which mushroom body α axon guidance may occur, since these axons express Drl-2 protein.

(Reynaud et al., 2015)

drl functions cell-autonomously in the projection neurons to promote the targeting of their dendrites to the dorsolateral region of the adult antennal lobe.

(Wu et al., 2014)

drl and Wnt5 are required (in the salivary gland and in the central nervous system respectively) for normal salivary gland migration in the embryo. They are required in the third phase of migration, to mediate the final positioning of the gland, as the salivary gland detaches from the circular visceral mesoderm and contacts the longitudinal visceral mesoderm.

(Harris and Beckendorf, 2007)

drl functions in glial cells, where it acts upstream of Wnt5 to modulate its function in glomerular patterning of the antennal lobe.

(Yao et al., 2007)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in cytokinetic index is seen.

(Bettencourt-Dias et al., 2004)

drl is essential for Wnt (Wnt5) mediated axon guidance.

(Yoshikawa et al., 2003)

Mutation of drl causes behavioral defects independently of pigeon.

(Moreau-Fauvarque et al., 2002)

The memory phenotype of drl mutants appears to be a consequence of abnormal brain development due to loss of function of the drl receptor tyrosine kinase.

(Moreau-Fauvarque et al., 2002)

A predicted kinase-deficient drl transgene retains drl function in two separate assays, suggesting that drl does not require kinase activity in vivo.

(Yoshikawa et al., 2001)

Expression of drl in each of four subclasses of anterior commissural neurons is controlled by separate transcriptional regulatory sequences.

(Bonkowsky and Thomas, 1999)

drl acts as a guidance receptor for a repellent ligand present in the posterior commissure in the developing embryonic nervous system.

(Bonkowsky et al., 1999)

P-element transformation vectors containing drl regulatory sequences show insertion site homing capability.

(Taillebourg and Dura, 1999)

drl mutants show structural brain defects in the adult central complex and mushroom bodies.

(Moreau-Fauvarque et al., 1998)

Loss of drl function is responsible for ventral attachment defects, muscle phenotype can be rescued by expression of a drl cDNA.

(Callahan et al., 1996)

Neurons and muscles use common mechanisms to recognise their paths or targets. drl plays an analogous role in both developing systems.

(Callahan et al., 1996)

drl maps 70kb proximal to Ddc.

(Callahan et al., 1995)

drl plays a key controlling role in the multiple discrete steps of neuronal pathway recognition. Results predict that once activated by its ligand drl controls pathway selection by modulating the function of specific cell adhesion molecules that mediate proper axon fasciculation.

(Callahan et al., 1995)

The drl gene product may be part of an atypical signal transduction cascade involved in the development of the adult brain.

(Dura et al., 1995)

Behaviour-genetic data suggests that 'lio' is non-vital.

(Dura et al., 1993)

'lio' is involved with learning and memory.

(Dura et al., 1993)

Origin and Etymology

Discoverer

Etymology

In French someone who forgets everything is said to be a "tete de linotte," the equivalent of bird-brain in English.

(Dura et al., 1993)

Identification

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44355

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q27324

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q27324

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PDD9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q27324

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015380

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015380

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44355/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015380

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015380

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015380

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17348

Flygut - An atlas of the Drosophila adult midgut

FBgn0015380

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44355

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG17348

MARRVEL_MODEL - MARRVEL (model organism gene)

44355

modMine - A data warehouse for the modENCODE project

FBgn0015380

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q27324

Linkouts

BioGRID - A database of protein and genetic interactions.

69001

DroID - A comprehensive database of gene and protein interactions.

FBgn0015380

DRSC - Results frm RNAi screens

FBgn0015380

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015380

FlyMine - An integrated database for Drosophila genomics

FBgn0015380

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

drl

MIST (protein-protein) - An integrated Molecular Interaction Database

drl

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG10758

(Roos, 2000.4.14)

CG17348

(Schwartz et al., 2016, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Morrison et al., 2000, Roos, 2000.4.14)

DRL

(Petrova et al., 2013, Katsuki et al., 2009, Prokopenko and Thomas, 2002)

Drl

(Shi et al., 2021, Koch et al., 2017, Garelli et al., 2015, Yasunaga et al., 2015, Chilton, 2006)

derailed

(Reynaud et al., 2015, Edwards et al., 2006)

drl

(Boulanger et al., 2021, Michki et al., 2021, Pan and O'Connor, 2021, Hing et al., 2020, Nye et al., 2020, Donato et al., 2019, Mele and Johnson, 2019, Meltzer et al., 2019, Zhu et al., 2019, Song et al., 2017, Clandinin and Owens, 2016-, Yuan et al., 2016, Chakraborty et al., 2015, Reynaud et al., 2015, Ugrankar et al., 2015, Fedotov et al., 2014, Kerr et al., 2014, Sopko et al., 2014, Weitkunat and Schnorrer, 2014, Wu et al., 2014, Lavagnino et al., 2013, O'Donnell and Bashaw, 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Japanese National Institute of Genetics, 2012.5.21, Lahaye et al., 2012, Jungreis et al., 2011, Biehs et al., 2010, Singh et al., 2010, Ayroles et al., 2009, Krejcí et al., 2009, Sakurai et al., 2009, Seugnet et al., 2009, Zlatic et al., 2009, Allen and Spradling, 2008, Chen and Condron, 2008, Liebl et al., 2008, Wouda et al., 2008, Buszczak et al., 2007, Dietzl et al., 2007, Grillenzoni et al., 2007, Harris and Beckendorf, 2007, Xia and Tully, 2007, Yao et al., 2007, Zeitlinger et al., 2007, Bovolenta et al., 2006, Jordan et al., 2006, Pallavi et al., 2006, Sandmann et al., 2006, Brodsky et al., 2004, Hall, 2003)

lin

(Roman and Davis, 2001)

lio/drl

(Taillebourg and Dura, 2000)

Name Synonyms

Derailed

(Mele and Johnson, 2019, Yasunaga et al., 2015, Sopko and Perrimon, 2013, Lahaye et al., 2012, Niehrs, 2012, Liebl et al., 2008, Bovolenta et al., 2006, Clevers, 2006, Gordon and Nusse, 2006)

derailed

(Garelli et al., 2015, Cridland et al., 2013, O'Donnell and Bashaw, 2013, Petrova et al., 2013, Biehs et al., 2010, Krejcí et al., 2009, Chen and Condron, 2008, Wouda et al., 2008, Harris and Beckendorf, 2007, Yao et al., 2007, Chilton, 2006, Edwards et al., 2006, Jordan et al., 2006, Pallavi et al., 2006, Hall, 2003, Callahan, 1995.9.13)

linotte

(Dissel et al., 2015, Dura et al., 2007, Tully and Xia, 2006, Hall, 2003, Ringrose et al., 2003, Hitier et al., 2000, Dura and Taillebourg, 1999, Shapiro, 1999, Moreau et al., 1998, Moreau et al., 1997, Dura et al., 1995)

lionette

(Pallavi and Shashidhara, 2003)

Secondary FlyBase IDs

FBgn0032764
FBgn0032765

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (210)