FlyBase Gene Report: Dmel\dsf

General Information

Symbol

Dmel\dsf

Species

D. melanogaster

Name

dissatisfaction

Annotation Symbol

CG9019

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015381

Gene Model Status

Current

Stock Availability

22 publicly available

Gene Summary

dissatisfaction (dsf) encodes a nuclear receptor that regulates hemocyte proliferation, courtship behavior and neural differentiation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

26A1-26A2

Sequence location

2L:5,925,937..5,939,261 [+]

Recombination map

2-18

RefSeq locus

NT_033779 REGION:5925937..5939261

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables DNA-binding transcription repressor activity, RNA polymerase II-specific

inferred from direct assay

(Pitman et al., 2002)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity

traceable author statement

(Schutt and Nothiger, 2000)

inferred from electronic annotation with InterPro:IPR001628

(InterPro Project Members, 2004-)

enables nuclear receptor activity

non-traceable author statement

(Maglich et al., 2001)

inferred from biological aspect of ancestor with PANTHER:PTN000638895

(GO Reference Genome Project, 2011-)

traceable author statement

(Greenspan and Ferveur, 2000)

enables nuclear steroid receptor activity

non-traceable author statement

(Sokolowski, 2001)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000638895

(GO Reference Genome Project, 2011-)

enables sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR001628

(InterPro Project Members, 2004-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088

(InterPro Project Members, 2004-)

Biological Process (13 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in egg-laying behavior

inferred from mutant phenotype

(Finley et al., 1997)

involved_in mating behavior, sex discrimination

inferred from mutant phenotype

(Finley et al., 1997)

involved_in regulation of female receptivity

inferred from mutant phenotype

(Finley et al., 1997)

involved_in regulation of hemocyte proliferation

inferred from mutant phenotype

(Sinenko et al., 2010)

Terms Based on Predictions or Assertions (12 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN000638895

(GO Reference Genome Project, 2011-)

involved_in copulation

non-traceable author statement

(Emmons and Lipton, 2003, Sokolowski, 2001)

involved_in courtship behavior

non-traceable author statement

(Sokolowski, 2001, Greenspan and Ferveur, 2000)

traceable author statement

(Emmons and Lipton, 2003)

involved_in egg-laying behavior

traceable author statement

(Billeter et al., 2002)

non-traceable author statement

(Sokolowski, 2001)

involved_in male courtship behavior

traceable author statement

(Billeter et al., 2002)

involved_in mating behavior, sex discrimination

traceable author statement

(Emmons and Lipton, 2003)

involved_in mating behavior

non-traceable author statement

(Zarkower, 2001)

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088

(InterPro Project Members, 2004-)

involved_in regulation of female receptivity

non-traceable author statement

(Billeter et al., 2002)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000638895

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with MGI:MGI:1100526

(Gene Ontology Curators, 2002-)

involved_in sex determination

traceable author statement

(Greenspan and Ferveur, 2000)

involved_in somatic sex determination

non-traceable author statement

(Schutt and Nothiger, 2000)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the nuclear hormone receptor family. NR2 subfamily. (Q9VML1)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

dissatisfaction (dsf) encodes a nuclear receptor that regulates hemocyte proliferation, courtship behavior and neural differentiation. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -: Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).

Protein Function (UniProtKB)

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' (PubMed:11977984). Acts as a transcriptional repressor (PubMed:11977984). In both females and males, functions downstream of tra2 to regulate the development and function of certain sex-specific abdominal neurons, and likely regulates the development and/or function of the nervous system that controls courtship behaviors involved in the recognition and response of adults to appropriate sexual partners (PubMed:11977984, PubMed:9023356, PubMed:9883729). In males, promotes abdominal motor neuronal innervation of the ventral muscles of abdominal segment 5 which is required for correct abdominal curling during copulation (PubMed:9023356, PubMed:9883729). In females, also promotes abdominal motor neuronal innervation but on the uterine muscles which is required for egg laying (PubMed:9023356, PubMed:9883729).

(UniProt, Q9VML1)

Summary (Interactive Fly)

nuclear receptor superfamily - essential for many aspects of sexual behavior and neural development in both males and females

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dsf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VML1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dsf-RA

FBtr0079145

NM_057792

3042

691

dsf-RB

FBtr0333245

NM_001273180

3537

691

Additional Transcript Data and Comments

Reported size (kB)

3.7 (northern blot)

(Finley et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

dsf-PA

FBpp0078776

74.1

691

8.44

FBpp0305445

74.1

691

8.44

Q9VML1

NP_001260109

AGB92645

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

691 aa isoforms: dsf-PA, dsf-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

693 (aa)

(Finley et al., 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VML1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dsf using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dsf_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.37

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Finley et al., 1998)

larval stage

larval brain | anterior

(Finley et al., 1998)

embryonic/larval salivary gland

(Finley et al., 1998)

pupal stage

anterior protocerebral neuromere | restricted

(Finley et al., 1998)

pharate adult stage

adult brain | restricted

(Finley et al., 1998)

Additional Descriptive Data

dsf expression is detected at all stages on northern blots. In situ hybridization to cryostat sections from larvae, pupae, and pharate adults shows expression restricted to a small number of neurons in the brain. In larvae, three labelled groups of cells are found in the anterior region of the brain. Weak expression was also observed in the salivary gland. In pupae, expression is detected in several small groups of cells in the anterior regions of the protocerebrum. In pharate adults, only a few labelled cells are found. About 20 large neurons are located close to the antennal lobe and lateral protocerebral neuropil. A cluster of about 10 cells is found just below the chemosensory region of the antennal lobe and near the mechanosensory region of the antennal lobe and subesophageal neuropils. In some cases a small number of expressing cells are found in the dorsal-most regions of the brain along the midline.

(Finley et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{dsf-GAL4.1.8}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval ventral nerve cord

(Pitman et al., 2002)

salivary gland

(Pitman et al., 2002)

pupal stage

adult ventral nerve cord

(Pitman et al., 2002)

eye disc

(Pitman et al., 2002)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dsf in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dsf

View exonic expression by tissue for Dmel\dsf

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015381

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33823/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015381

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015381

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015381

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0015381

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dsf

Transgenic constructs containing regulatory region of dsf

Aberrations (Deficiencies and Duplications) ( 8 )

Inferred from experimentation ( 8 )

Gene disrupted in

Df(2L)cl7

(Finley et al., 2003, Finley et al., 1997)

Df(2L)dsf3

(Finley et al., 2003)

Df(2L)dsf4

(Finley et al., 2003)

Df(2L)Exel6014

(Ryder, 2004.4.26)

Df(2L)Exel7024

(Ryder, 2004.4.26)

Df(2L)w3

(Finley et al., 2003)

Df(2L)w12

(Simonsen et al., 2007)

Gene not disrupted in

Df(2L)Gpdh1-78

(Finley et al., 1997)

Inferred from location ( 15 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage, with Scer\GAL4^elav.PLu

lethal | larval stage, with Scer\GAL4^elav.PLu

lethal - all die before end of larval stage, with Scer\GAL4^h-1J3

dsf^VP16.UAS

lethal - all die before end of P-stage, with Scer\GAL4^Alk.6.5

dsf^VP16.UAS

lethal - all die during embryonic stage, with Scer\GAL4^Act5C.PI

lethal - all die during embryonic stage, with Scer\GAL4^Dll-md23

lethal - all die during embryonic stage, with Scer\GAL4^h-1J3

dsf^UAS.cPa

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dsf^GD15609

partially lethal - majority die, with Scer\GAL4^Alk.6.5

dsf^UAS.cPa

partially lethal - majority die, with Scer\GAL4^GMR.PF

dsf^{Δ172-322.UAS}

viable, with Scer\GAL4^dpp.blk1

dsf^VP16.UAS

viable, with Scer\GAL4^GMR.PF

dsf^VP16.UAS

viable, with Scer\GAL4^Mef2.PR

dsf^GD15609

viable, with Scer\GAL4^pnr-MD237

dsf^GD15609

viable, with Scer\GAL4^tin.CΔ4

dsf^GD15609

Sterility

Allele

fertile, with Scer\GAL4^dpp.blk1

dsf^VP16.UAS

fertile, with Scer\GAL4^GMR.PF

dsf^VP16.UAS

Other Phenotypes

Allele

abnormal behavior | male

dsf¹

abnormal behavior | male limited, with Scer\GAL4^elav-C155

dsf^JF02537

abnormal courtship behavior | female

dsf¹

abnormal courtship behavior | male

dsf¹

abnormal mating | male | recessive

dsf¹

abnormal neuroanatomy

dsf¹

melanotic necrosis, with Scer\GAL4^GMR.PF

some die during embryonic stage, with Scer\GAL4^Act5C.PI

some die during embryonic stage, with Scer\GAL4^Dll-md23

some die during embryonic stage, with Scer\GAL4^h-1J3

dsf^UAS.cPa

some die during larval stage, with Scer\GAL4^h-1J3

dsf^VP16.UAS

some die during pharate adult stage, with Scer\GAL4^Alk.6.5

dsf^VP16.UAS

visible, with Scer\GAL4^dpp.blk1

dsf^{1-172.VP16.UAS}

visible, with Scer\GAL4^GMR.PF

wild-type, with Scer\GAL4^dpp.blk1

dsf^VP16.UAS

Phenotype manifest in

Allele

adult abdominal segment 5 & synapse | male (with Df(2L)cl7)

dsf¹

arista, with Scer\GAL4^dpp.blk1

dsf^UAS.cPa

eye, with Scer\GAL4^dpp.blk1

dsf^{1-172.VP16.UAS}

eye, with Scer\GAL4^GMR.PF

eye | ectopic | posterior, with Scer\GAL4^dpp.blk1

dsf^UAS.cPa

interommatidial bristle, with Scer\GAL4^GMR.PF

leg | distal, with Scer\GAL4^dpp.blk1

leg | distal | ectopic, with Scer\GAL4^dpp.blk1

dsf^{1-172.VP16.UAS}

mesonotum, with Scer\GAL4^dpp.blk1

dsf^UAS.cPa

metathoracic leg, with Scer\GAL4^Alk.6.5

dsf^VP16.UAS

ommatidium, with Scer\GAL4^GMR.PF

pigment cell, with Scer\GAL4^GMR.PF

pupa | posterior, with Scer\GAL4^Alk.6.5

dsf^UAS.cPa

tarsal segment, with Scer\GAL4^dpp.blk1

dsf^UAS.cPa

third segment of antenna | ectopic, with Scer\GAL4^dpp.blk1

dsf^{1-172.VP16.UAS}

wing, with Scer\GAL4^dpp.blk1

dsf^UAS.cPa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (48)

Hsap\NR2E1

5 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\NR0B2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (27)

Rnor\Nr2e1

5 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Nr0b2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Nr2e1

5 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Nr0b2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (28)

Xtro\nr2e1

4 of 13

Yes

Xtro\nr2e3

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (38)

Drer\nr2e1

5 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\nr0b2a

1 of 14

Yes

Drer\nr0b2b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (125)

Cele\nhr-67

5 of 14

Yes

Cele\fax-1

3 of 14

Cele\nhr-91

2 of 14

Cele\nhr-236

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\nhr-1

1 of 14

Cele\nhr-3

1 of 14

Cele\nhr-4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\nhr-22

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\nhr-64

1 of 14

Cele\nhr-66

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\nhr-106

1 of 14

Cele\nhr-107

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP009575

11 of 12

Yes

Agam\AgaP_AGAP012921

4 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dsf. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (19)

tll

6 of 13

Hr51

4 of 13

svp

4 of 13

Hnf4

3 of 13

Hr78

2 of 13

Hr83

2 of 13

usp

2 of 13

EcR

1 of 13

Eip75B

1 of 13

Eip78C

1 of 13

ERR

1 of 13

ftz-f1

1 of 13

Hr3

1 of 13

Hr38

1 of 13

Hr39

1 of 13

Hr96

1 of 13

kni

1 of 13

knrl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

dsf^MB03062

exacerbates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NR2E1; nuclear receptor subfamily 2 group E member 1

5 of 14

603849

NR2E3; nuclear receptor subfamily 2 group E member 3

4 of 14

604485

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59988

DroID - A comprehensive database of gene and protein interactions.

FBgn0015381

MIST (protein-protein) - An integrated Molecular Interaction Database

33823

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-18

Cytogenetic map

26A1-26A2

Sequence location

2L:5,925,937..5,939,261 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

26A1-26A2

Limits computationally determined from genome sequence between P{EP}bchs^EP2299&P{EP}Gpdh^EP466 and P{lacW}chic^k13321

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

26A-26A

(Finley, 1998.11.13)

Mapped by complementation studies (details unspecified).

(Finley et al., 1997)

Experimentally Determined Recombination Data

Location

2-18

(FlyBase, 2016)

2-19.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (22)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

49501

w¹¹¹⁸; P{GMR29G10-GAL4}attP2

52751

w¹¹¹⁸; P{GMR29G10-lexA}attP40

43949

w¹¹¹⁸; PBac{dsf-GFP.FLAG}VK00033

74628

w¹¹¹⁸; P{VT002996-GAL4.DBD}attP2

23510

w¹¹¹⁸; Mi{ET1}dsf^MB03062

28865

w¹¹¹⁸; P{hs-GAL4-dsf.LBD.HA}8.1/CyO

29373

y¹ v¹; P{TRiP.JF02537}attP2

41707

y¹ v¹; P{TRiP.HMS02272}attP40

Korea

12038

P{VT002996-GAL4}attP2

14690

P{VT002996-lexA::GADfl}attP40

VDRC

v330162

P{VSH330162}attP40

v33909

w¹¹¹⁸; P{GD15609}v33909/CyO

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015381

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015381

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mutant virgin females rebuff male courtship.

(Finley et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG9019

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Ni et al., 2010.12.1, Perkins et al., 2009, Macdonald and Long, 2006)

DSF

(Misra et al., 2017, Jaumouillé et al., 2015, Fahrbach et al., 2012, Lin et al., 2009, de Rosny et al., 2008, Palanker et al., 2006, Pitman et al., 2002)

Dsf

(Sinenko et al., 2010)

NR2E4

(King-Jones and Thummel, 2005)

dissatisfaction

(Edwards et al., 2006)

dsf

(Duckhorn et al., 2022, Ables et al., 2016, Zhao et al., 2015, Davis et al., 2014, Toshima et al., 2014, Hammonds et al., 2013, Spokony and White, 2013.5.10, Catalán et al., 2012, Laturney and Moehring, 2012, Williams et al., 2012, Dubrovsky et al., 2011, Sinenko et al., 2010, Simonsen et al., 2007)

Name Synonyms

Dissatisfaction

(King-Jones and Thummel, 2005)

dissatisfaction

(Davis et al., 2014, Williams et al., 2012, Sinenko et al., 2010, Robin et al., 2007, Edwards et al., 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33823

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VML1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VML1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VML1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015381

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33823/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015381

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015381

FlyMine - An integrated database for Drosophila genomics

FBgn0015381

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9019

MARRVEL_MODEL - MARRVEL (model organism gene)

33823

Linkouts

BioGRID - A database of protein and genetic interactions.

59988

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015381

DroID - A comprehensive database of gene and protein interactions.

FBgn0015381

DRSC - Results frm RNAi screens

FBgn0015381

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dsf_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015381

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015381

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0015381

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001069

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

33823

References (95)

The following external sites may use different assemblies or annotations than FlyBase.

-0.37

Report Sections