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FB2025_04
,
released October 2, 2025
Dom, jumeaux, Domina, l(3)06439, l(3)06142
forkhead/winged-helix class - a suppressor of position effect variegation that also affects and regulates eye and bristle development - acts upstream of a Polo-kinase dependent pathway - its roles included asymmetric protein localization, chromatin modification, dendrite formation and organ (eye, wing and bristle) development
Please see the JBrowse view of Dmel\jumu for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jumu using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as dorsal/lateral sensory complexes
Comment: anlagen
jumu protein is expressed in prohemocytes and in the lymph gland throughout larval development. Expression is also observed in cardial cells (cardiomycytes).
JBrowse - Visual display of RNA-Seq signals
View Dmel\jumu in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-ThermoFischer : S2 cells stably expressing Tag:FLAG-jumu were created.
jumu is required during asymmetric cell division for the derivation of two distinct cardial cells types (svp-expressing cardial cell and svp-expressing pericardial cell) from their mutual precursor. It is also required in symmetric cell divisions that produce the tin-expressing cardial cells. jumu controls the division of the cardiac progenitors by regulating the activity of polo.
DNA-protein interactions: genome-wide binding profile assayed for jumu protein in 0-12 hr embryos; see mE1_TFBS_jumu collection report.
jumu behaves as a haplo-suppressor/triplo-enhancer of position effect variegation in a number of tissues, but behaves in the reverse manner as a haplo-enhancer/triplo-suppressor in larval and adult brains.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of jumu causes an increase in class I da neuronal number as well as defects in dendrite morphogenesis. RNAi also causes defects in muscle, alterations in the number of MD neurons and reproducible defects in da dendrite development.
Identification: In a screen for chromosome inheritance modifiers.
jumu appears to have dual functions. It appears to play a role in development and cause large-scale modifications of chromatin.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Identified as a female-specific suppressor of position effect variegation.
Source for merge of: jumu l(3)06439
Source for merge of: E(var)631 Dom l(3)06439
The relationship between "stich1" and "jumu" is unclear. They may be allelic. "stich1EP359" fails to complement "stich1S143702" and "stich1D233" but the P{EP} insertion in "stich1EP359" maps to the first intron of "jumu". Flanking sequence recovered from either side of the P{lacW} insertion in "stich1S143702" are located at least 28kb apart on the genomic sequence. This suggests that there may be 2 different P{lacW} elements that map 28kb apart in the "l(3)S143702" line, or the P{lacW}stich1S143702 insertion may be associated with a 28kb deletion. One set of flanking sequence indicates that the P{lacW} element is inserted approximately 90bp upstream of the 5' end of the GM05287 cDNA. The other set of flanking sequence maps within the first intron of "jumu", suggesting that both GM05287 and "jumu" may be affected in the "l(3)S143702" line. The molecular nature of the "stich1D233" mutation is not known.
It is not clear which gene is affected in "stich1" mutants, since the lesion in the "l(3)S143702" "stich1" mutant allele contains a deficiency which removes both "jumu" and "Rfx" sequences, associated with a P{lacW} insertion which is within the "jumu" gene and maps only approximately 90bp upstream of the 5' end of the "CG17100" GM05287 cDNA. "stich1" mutants complement "Rfx" mutants, so "stich1" likely corresponds to one of "jumu" and "CG17100" (see FBrf0151940 and FBrf0131381).
