kek, kekkon, kek-1, kekon, uns
Ig domain protein, Leucine-rich repeat protein - plays a role in axonal outgrowth in the central nervous system - acts in a negative feedback loop to modulate the activity of the Egfr tyrosine kinase during oogenesis
Please see the JBrowse view of Dmel\kek1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.45
Gene model reviewed during 5.46
Gene model reviewed during 6.02
5.5 (northern blot)
880 (aa); 92 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kek1 using the Feature Mapper tool.
Expression pattern inferred from unspecified enhancer trap line.
kek1 transcripts are detected in9-13hr embryos on northern blots. They are detected by in situhybridization early in the midline and later in most neurons in the CNS.In the PNS, they are expressed in cap cells and weakly in ventral andlateral clusters. They are also expressed in the antenno-maxillary complexand in ovaries in a pattern similar to that of the corresponding enhancertrap line (Ecol\lacZkek1-15A6).
Comment: notum
GBrowse - Visual display of RNA-Seq signals
View Dmel\kek1 in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: kek1 BEST:GM02380
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167: binucleate cells.
Original 'unstrung' phenotype was in fact due to deletion of more than one gene, one of which has been shown to be kek1.
Mutants of kek1 exhibit missing intersegmental longitudinal tracts.