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Gene Dmel\ksr

General Information
Symbol	Dmel\ksr	Species	D. melanogaster
Name	kinase suppressor of ras	Annotation symbol	CG2899
Feature type	protein_coding_gene	FlyBase ID	FBgn0015402
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(3)j5E2, KSR-1
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	83A5-83A5	Sequence location	3R:1,305,871..1,309,607 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene kinase suppressor of ras is referred to in FlyBase by the symbol Dmel\ksr (CG2899, FBgn0015402). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; diacylglycerol binding; protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: Ras protein signal transduction; tracheal outgrowth, open tracheal system; imaginal disc-derived wing morphogenesis; signal transduction. 45 alleles are reported. The phenotypes of these alleles are annotated with: eye; photoreceptor cell; mesothoracic tergum; eye photoreceptor cell; wing; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1625295_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ksr. Gene sequence location is 3R:1305871..1309607.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN50560 HFA12379 BKN50458 BKN27788
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A5-83A5   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83A3-83A5     (Therrien, 1995.12.19) 83A5-83A6   (determined by in situ hybridisation)   (Spradling et al., 1999) 83A5-83A6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Therrien, 1995.12.19) 3-47.5 (Therrien et al., 1995)
Left of (cM)
Right of (cM)
Notes	P{lacW}1025 (at 82F8-10) maps to the left of P{lacW}ksrj5E2 (at 83A5-83A6). (Therrien et al., 1995)
Gene Model & Products
Please see the GBrowse view of Dmel\ksr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ksr-RA FBtr0078766  NM_079512   3737   966
Additional Transcript Data & Comments
Reported size (kB)	3.6 (northern blot) (Therrien et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ksr-PA   FBpp0078413   105.8   966   7.97     NP_524236   AAF52021
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140743   AA264013   AA391647   AA439433   AA439445   AA539580   AA940869   AA951764   AE014297 AAF52021   AQ026325   AY135094 AAN17646   AY135095 AAN17647   AY135096 AAN17648   AY135097 AAN17649   AY135098 AAN17650   AY135099 AAN17651   AY135100 AAN17652   AY135101 AAN17653   AY135102 AAN17654   AY135103 AAN17655   AY135104 AAN17656   AY135105 AAN17657   AY135106 AAN17658   AY135107 AAN17659   AY135108 AAN17660   AY135109 AAN17661   AY135110 AAN17662   AY135111 AAN17663   AY135112 AAN17664   AY135113 AAN17665   AY135114 AAN17666   AY135115 AAN17667   AY135116 AAN17668   BF502173   BF505963   BI235599   BI236380   BT011010   CL610106   CO265656   CO283261   CO292719   CO303198   CO304454   CO305696   CO313921   CO336104   DQ138860 ABA86466   EC052102   EC053116   EC055469   EC055907   EC056566   EC065622   EC075129   EC089642   EC203470   EC214064   EC216207   EC225718   EC233365   EC233966   EC235926   EC264155   EL881648   EL881649   U43582 AAC46969   U43583 AAC46970   Z83466
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24170 Q24171 Q2XY02 Q8I0R4 Q8ISD7 Q8ISD8 Q8ISD9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015402    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015402 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015402 expression level Developmental Stage   Expression Level embryo 00-02hr    2941 embryo 02-04hr    2540 embryo 04-06hr    2113 embryo 06-08hr    2211 embryo 08-10hr    1957 embryo 10-12hr    1577 embryo 12-14hr    1355 embryo 14-16hr    1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day    1602 adult female 30day    1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2941) embryo 02-04hr  (2540) embryo 04-06hr  (2113) embryo 06-08hr  (2211) embryo 08-10hr  (1957) embryo 10-12hr  (1577) embryo 12-14hr  (1355) embryo 14-16hr  (1542) embryo 16-18hr  (1103) embryo 18-20hr  (938) embryo 20-22hr  (800) embryo 22-24hr  (839) larva L1  (696) larva L2  (437) larva L3 12hr old  (357) larva L3 puffstage 1-2  (378) larva L3 puffstage 3-6  (674) larva L3 puffstage 7-9  (790) white prepupae new  (773) white prepupae 12hr  (913) white prepupae 24hr  (1257) pupae 2d postWPP  (899) pupae 3d postWPP  (592) pupae 4d postWPP  (511) adult male 01day  (631) adult male 05day  (809) adult male 30day  (839) adult female 01day  (1192) adult female 05day  (1602) adult female 30day  (1776) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2941) embryo 02-04hr  (2540) embryo 04-06hr  (2113) embryo 06-08hr  (2211) embryo 08-10hr  (1957) embryo 10-12hr  (1577) embryo 12-14hr    1355 embryo 14-16hr  (1542) embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day  (1602) adult female 30day  (1776) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2941 embryo 02-04hr    2540 embryo 04-06hr    2113 embryo 06-08hr    2211 embryo 08-10hr    1957 embryo 10-12hr    1577 embryo 12-14hr    1355 embryo 14-16hr    1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day    1602 adult female 30day    1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2941 embryo 02-04hr    2540 embryo 04-06hr    2113 embryo 06-08hr    2211 embryo 08-10hr    1957 embryo 10-12hr    1577 embryo 12-14hr    1355 embryo 14-16hr    1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day    1602 adult female 30day    1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015402 expression level Developmental Stage   Expression Level embryo 00-02hr    2941 embryo 02-04hr    2540 embryo 04-06hr    2113 embryo 06-08hr    2211 embryo 08-10hr    1957 embryo 10-12hr    1577 embryo 12-14hr    1355 embryo 14-16hr    1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day    1602 adult female 30day    1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2941) embryo 02-04hr  (2540) embryo 04-06hr  (2113) embryo 06-08hr  (2211) embryo 08-10hr  (1957) embryo 10-12hr  (1577) embryo 12-14hr  (1355) embryo 14-16hr  (1542) embryo 16-18hr  (1103) embryo 18-20hr  (938) embryo 20-22hr  (800) embryo 22-24hr  (839) larva L1  (696) larva L2  (437) larva L3 12hr old  (357) larva L3 puffstage 1-2  (378) larva L3 puffstage 3-6  (674) larva L3 puffstage 7-9  (790) white prepupae new  (773) white prepupae 12hr  (913) white prepupae 24hr  (1257) pupae 2d postWPP  (899) pupae 3d postWPP  (592) pupae 4d postWPP  (511) adult male 01day  (631) adult male 05day  (809) adult male 30day  (839) adult female 01day  (1192) adult female 05day  (1602) adult female 30day  (1776) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2941) embryo 02-04hr  (2540) embryo 04-06hr  2113 embryo 06-08hr  2211 embryo 08-10hr  1957 embryo 10-12hr  1577 embryo 12-14hr    1355 embryo 14-16hr  1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day  1602 adult female 30day  1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2941 embryo 02-04hr    2540 embryo 04-06hr    2113 embryo 06-08hr    2211 embryo 08-10hr    1957 embryo 10-12hr    1577 embryo 12-14hr    1355 embryo 14-16hr    1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day    1602 adult female 30day    1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2941 embryo 02-04hr    2540 embryo 04-06hr    2113 embryo 06-08hr    2211 embryo 08-10hr    1957 embryo 10-12hr    1577 embryo 12-14hr    1355 embryo 14-16hr    1542 embryo 16-18hr    1103 embryo 18-20hr    938 embryo 20-22hr    800 embryo 22-24hr    839 larva L1    696 larva L2    437 larva L3 12hr old    357 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    674 larva L3 puffstage 7-9    790 white prepupae new    773 white prepupae 12hr    913 white prepupae 24hr    1257 pupae 2d postWPP    899 pupae 3d postWPP    592 pupae 4d postWPP    511 adult male 01day    631 adult male 05day    809 adult male 30day    839 adult female 01day    1192 adult female 05day    1602 adult female 30day    1776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015402    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015402 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015402 expression level Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015402 expression level Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    86.7 Larval Midgut    36.7 Larval Hindgut    51.9 Larval Malpighian Tubules    33.9 Larval Fat Body    39.2 Larval Salivary Gland    53.2 Larval Trachea    73.1 Larval Carcass    40.6 Adult Head    58.7 Adult Eye    47.5 Adult Brain    135.1 Adult Thoracic-Abdominal Ganglion    80.6 Adult Crop    59.5 Adult Midgut    25.8 Adult Hindgut    42.1 Adult Malpighian Tubules    48.3 Adult Fat Body    42.6 Adult Salivary Gland    72.6 Adult Heart    47.225 Adult VirginFemale Spermatheca    47.8 Adult InseminatedFemale Spermatheca    56.1 Adult Ovary    139.3 Adult Testis    49.3 Adult Male Accessory Gland    76.7 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    58.7   NA  Eye    47.5   NA  Brain    135.1   86.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    80.6   NA  Crop    59.5   36.7  Midgut    25.8   51.9  Hindgut    42.1   33.9  Malpighian Tubules    48.3   39.2  Fat Body    42.6   53.2  Salivary Gland    72.6   NA  Heart    47.225   73.1  Trachea    NA   NA  VirginFemale Spermatheca    47.8   NA  InseminatedFemale Spermatheca    56.1   NA  Ovary    139.3   NA  Testis    49.3   NA  Male Accessory Gland    76.7   40.6  Carcass    48.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015402 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2899-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive ksr3R-148-40 lethal | pupal stage, with Scer\GAL4pnr-MD237 ksrGD9845 lethal | recessive ksr3R-148-40 ksr7M6 ksrj5E2 ksrS-69 ksrS-511 ksrS-627 ksrS-638 ksrS-721 ksrunspecified ksrXS-337 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ksrGD9845 Other Phenotypes Allele visible ksrS-548 visible, with Scer\GAL4pnr-MD237 ksrGD9845 visible | dominant ksrj5E2 visible | recessive ksrS-548 Phenotype manifest in Allele A1-7 ventral acute muscle 2 | precursor ksrs628 abdominal segment 8 & cephalopharyngeal skeleton | germ-line clone ksrS-638 abdominal segment 9 & cephalopharyngeal skeleton | germ-line clone ksrS-638 abdominal segment 10 & cephalopharyngeal skeleton | germ-line clone ksrS-638 abdominal segment 11 & cephalopharyngeal skeleton | germ-line clone ksrS-638 dorsal air sac primordium | somatic clone ksrS-638 embryo | germline clone | maternal effect | terminal ksr3R-148-40 eye ksrS-548 eye photoreceptor cell ksrS-548 mesothoracic tergum, with Scer\GAL4pnr-MD237 ksrGD9845 ommatidium ksrS-548 photoreceptor cell ksrS-548 terminalia | germline clone ksrS-638 wing ksrj5E2
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of ksr Class Mutagen Stocks Known lesion ksrEY01688 P-element activity 1 Yes ksrj5E2 P-element activity 1 -- ksrMI03491 1 -- ksrS-627 ethyl methanesulfonate 1 -- ksr1080 0 -- ksr3R-148-40 ethyl methanesulfonate 0 -- ksr7M6 loss of function allele ethyl methanesulfonate 0 -- ksrS-511 loss of function allele 0 Yes ksrS-548 hypomorphic allele - genetic evidence 0 Yes ksrS-638 loss of function allele 0 Yes ksrS-69 loss of function allele 0 Yes ksrS-721 loss of function allele 0 Yes ksrs628 0 -- ksrs721 0 -- ksrunspecified 0 -- ksrXS-2424 0 -- ksrXS-2832 0 -- ksrXS-337 X ray 0 --
Alleles Carried on Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ksr Class Mutagen Stocks Known lesion ksrGD9845 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ksrGL00153 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ksrHMS00730 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ksr+t7 in vitro construct - genomic fragment 0 Yes ksr1-655.MtnA.T:SV5\V5 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes ksr656-1003.MtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ksrA696V-A703T.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ksrC398S-C401S.MtnA in vitro construct - amino acid replacement 0 Yes ksrC922Y.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ksrC922Y.MtnA in vitro construct - amino acid replacement 0 Yes ksrD800A-D817A.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ksrD800A-D817A.MtnA in vitro construct - amino acid replacement 0 Yes ksrdsRNA.cAa in vitro construct - RNAi 0 Yes ksrdsRNA.cRa in vitro construct - RNAi 0 Yes ksrF518W.MtnA in vitro construct - amino acid replacement 0 Yes ksrG688E.MtnA.T:SV5\V5 loss of function allele in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ksrK705M.MtnA.T:Zzzz\FLAG,T:Myr1,T:Rnor\FRAP-FRB in vitro construct - coding region fusion 0 Yes ksrK705M.MtnA in vitro construct - amino acid replacement 0 Yes ksrKK107788 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ksrKM.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ksrL50S-R51G.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes ksrL50S-R51G.MtnA in vitro construct - amino acid replacement 0 Yes ksrMtnA.PR in vitro construct - regulatory fusion 0 Yes ksrMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ksrMtnA.T:Zzzz\FLAG,T:Myr1,T:Rnor\FRAP-FRB in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ksrMtnA.T:Zzzz\FLAG,T:Myr1-GA,T:Rnor\FRAP-FRB in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ksrR732H.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)e1025-14 (Therrien et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9845} NA P{KK107788} NA P{TRiP.GL00153} NA P{TRiP.HMS00730} NA characterization construct P{ksr+} NA P{sE-KDN.T} NA P{sE-tor[4021]-ksr.K>M} NA P{sE-tor4021-ksr.fl} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}ksrEY01688 NA P{GSV1}EP-17EP-17 NA insertion of enhancer trap P{lacW}ksrj5E2 No miscellaneous insertions Mi{MIC}HcsMI03491 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) Ras protein signal transduction inferred from genetic interaction with Ras85D (Therrien et al., 1995) signal transduction inferred from direct assay (Douziech et al., 2006) tracheal outgrowth, open tracheal system inferred from mutant phenotype (Cabernard and Affolter, 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) diacylglycerol binding inferred from sequence or structural similarity with InterPro:IPR002219 (FlyBase, 1992-) protein kinase activity inferred from sequence or structural similarity (Therrien et al., 1995) non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity with EMBL:U43586 (FlyBase, 1992-) non-traceable author statement (Therrien, 1995.12.19) protein tyrosine kinase activity inferred from electronic annotation with InterPro:IPR008266 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
anterior/posterior axis specification, embryo traceable author statement (Baek and Lee, 1999) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) torso signaling pathway non-traceable author statement (Baek and Lee, 1999)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ksr allele Gene References ksr7M6 phl (Li et al., 2000) ksrS-69 Ras85D (Therrien et al., 1995) ksrS-511 Ras85D (Therrien et al., 1995) ksrS-548 aop (Lai et al., 1997) PTP-ER (Karim and Rubin, 1999) Ras85D (Therrien et al., 1995) ttk (Lai et al., 1997) ksrS-627 aop (Karim et al., 1996) Dsor1 (Karim et al., 1996) phl (Karim et al., 1996) Ras85D (Karim et al., 1996) ksrS-638 C3G (Ishimaru et al., 1999) csw (Firth et al., 2000) phl::tor (Therrien et al., 1995) Ras85D (Therrien et al., 1995) ksrS-721 Ras85D (Therrien et al., 1995) ksrunspecified phl (Therrien et al., 2000) PTP-ER (Karim and Rubin, 1999) Ras85D (Therrien et al., 2000) ksrXS-337 aop (Karim et al., 1996) Dsor1 (Karim et al., 1996) phl (Karim et al., 1996) Ras85D (Karim et al., 1996) unspecified 14-3-3ε (Therrien et al., 2000) Akap200 (Huang and Rubin, 2000) alph (Therrien et al., 2000) aop (Therrien et al., 2000) chb (Huang and Rubin, 2000) cnk (Therrien et al., 2000) Dsor1 (Therrien et al., 2000) Egfr (Therrien et al., 2000) EK2-5 (Therrien et al., 2000) EK2-7 (Therrien et al., 2000) EK3-3 (Therrien et al., 2000) kis (Therrien et al., 2000) Lk6 (Huang and Rubin, 2000) MESK1 (Huang and Rubin, 2000) MESK2 (Huang and Rubin, 2000) MESK3 (Huang and Rubin, 2000) MESK4 (Huang and Rubin, 2000) MESR3 (Huang and Rubin, 2000) MESR4 (Huang and Rubin, 2000) MESR6 (Huang and Rubin, 2000) msn (Huang and Rubin, 2000) NFAT (Huang and Rubin, 2000) pnt (Therrien et al., 2000) Ret (Read et al., 2005) rl (Therrien et al., 2000) S (Therrien et al., 2000) SK2-3 (Therrien et al., 2000) Sos (Therrien et al., 2000) spen (Therrien et al., 2000) Src42A (Therrien et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65868 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015402 DroID - A comprehensive database of gene and protein interactions. • FBgn0015402 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40660
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17706 Dere\GG10992 Dgri\GH18995 Dmoj\GI24496 Dper\GL22162 Dpse\GA15503 Dsec\GM10629 Dsim\ksr Dvir\ksr Dwil\GK11853 Dyak\GE25276
Curated drosophilid orthologs	Dere\GG10992 (Comeron and Guthrie, 2005.7.21) Dkik\ksr   Dlii\ksr   Dpse\GA15503   Dsim\CG2899 (Comeron and Guthrie, 2005.7.21) Dsim\ksr   Dvir\ksr (Therrien, 1995.12.19) Dyak\GE25276 (Comeron and Guthrie, 2005.7.21)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008585-PA Aedes aegypti (mosquito) AGAP001482-PA Anopheles gambiae (mosquito) XP_393005.2 Apis mellifera (honey bee) XP_001951609.1 Acyrthosiphon pisum (pea aphid) At3g24550.1 Arabidopsis thaliana (wall cress) 230463 Branchiostoma floridae (lancelet) XP_001896094.1 Brugia malayi (roundworm nematode) BGIBMGA009848-PA Bombyx mori (silk worm) ENSBTAP00000008672 Bos taurus (bovine) CN12235 Caenorhabditis brenneri (small nematode) CBP29367 Caenorhabditis briggsae (nematode) CE25854 Caenorhabditis elegans (worm) ENSCAFP00000014510 Canis familiaris (dog) JA08556 Caenorhabditis japonica (nematode) CPIJ017063 Culex pipens (mosquito) ENSCPOP00000000731 Cavia porcellus (guinea pig) 171767 Chlamidomonas reinhardtii (green alga) RP37087 Caenorhabditis remanei (nematode) 228240 Capitella spl (polychaete worm) 329047 Daphnia pulex (daphnia) ENSDARP00000090579 Danio rerio (zebra fish) ENSECAP00000003395 Equus caballus (horse) ENSGACP00000026826 Gymnopilus aculeatus (mushroom) ENSGALP00000009104 Gallus gallus (chicken) 189079 Hypsipyla robusta (cedar shoot borer) ENSP00000323178 Homo sapiens (human) ISCW017442-PA Ixodes scapularis (deer tick) LmjF16.0870 Leishmania major (virus) ENSMODP00000019181 Monodelphis domestica (gray opossum) ENSMMUP00000023517 Macaca mulatta (rhesus monkey) ENSMUSP00000018478 Mus musculus (house mouse) XP_001605076.1 Nasonia vitripennis (wasp) ENSOANP00000009015 Ornithorynchus anatinus (platypus) ENSORLP00000001306 Oryzias latipes (japanese killifish) PHUM004849-PA Pediculus humanus (human body louse) 183239 Physcomitrella patens (moss) ENSPPYP00000009083 Pongo pygmaeus (orangutan) ENSPTRP00000015183 Pan troglodytes (chimpanzee) ENSRNOP00000038732 Rattus norvegicus (norway rat) 5055190 Sorghum bicolor (sorghum) Smp_037210 Schistosoma mansoni (trematode parasite) 59721 Trichoplax adhaerens (metazoa) XP_001812757.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014789 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029122 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046183 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15898 NV13823 LH19690 ISCW017442 FBgn0084173 FBgn0213864 FBgn0015212 FBgn0063983 FBgn0165575 JGI_V11_329047 FBgn0075520 FBgn0159754 FBgn0147218 FBgn0126462 FBgn0084866 FBgn0094724 CPIJ017063 BGIBMGA009848 ACYPI006112 GB12129 AGAP001482 AAEL008585 PHUM291680 GLEAN_05910
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	5683 ksrS-627/TM3, P{sevRas1.V12}FK2, Sb1 35262 y1 sc* v1; P{TRiP.GL00153}attP2 32937 y1 sc* v1; P{TRiP.HMS00730}attP2 10212 w1118; P{lacW}ksrj5E2/TM3, P{ftz/lacC}SC1, ryRK Sb1 Ser1 36242 y1 w*; Mi{MIC}HcsMI03491 ksrMI03491/TM3, Sb1 Ser1 19645 y1 w67c23; P{EPgy2}ksrEY01688 HcsEY01688/TM3, Sb1 Ser1
VDRC	v45040 w1118; P{GD9845}v45040 v45041 w1118; P{GD9845}v45041
Genomic Clones ( 2 )
	BACR24O24 BACR34M23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 37 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT08303
Other clones	DPiM_AT08303
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17821 LD07370 LD10667 LD14008 LD14021 LD17776 LD23165 LD32471 RE31484 RE32430
Other clones	32913 43396 72339 76660 107894 120486 146719 165654 190979 557007 CK00432 EC052102 EC053116 EC055469 EC055907 EC056566 EK143318 EK162726 EK200822 EK234313 EK240547 EK244726 EK249250 EN11840 IP11447
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015402 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40660
Antibody Information
	polyclonal (Stark et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ksr CG2899 (Zheng, 1999.11)
Source for database merge of	Source for merge of: ksr l(3)j5E2 (Spradling et al., 1999)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Douziech et al., 2006) cnk acts as a molecular platform that coordinates the assembly and activity of a phl-activating complex. ksr, which is recruited to cnk-bound phl by the ave protein, is a central component of the phl activation process. (Douziech et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Roignant et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) ksr protein facilitates the phosphorylation of Dsor1 protein by phl protein. ksr protein associates independently with phl and Dsor1 proteins, which results in the formation of a phl/Dsor1 complex. (Roy et al., 2002) Overexpression of ksr blocks R7 photoreceptor cell formation in the eye. (Cacace et al., 1999) The MAPK cascade is required for Ras85D mitogenic response, loss of function mutations in phl, Dsor1, rl and ksr dominantly suppress hyperplastic growth, as do mutations in the Ras85D effector loop that disrupt the Ras85D-phl interaction. (Karim and Rubin, 1998) aop and ttk mutations dominantly suppress eye phenotypes of ksr mutants. (Lai et al., 1997) Mutant phenotype indicates both aop and ttk are involved in the Ras/MAPK pathway. (Lai et al., 1997) Immunoprecipitation experiments reveals the physical association between the phl and ksr products in Drosophila embryos. (Therrien et al., 1996) A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl. (Therrien et al., 1995) ksr functions in multiple receptor tyrosine kinase pathways. (Therrien et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079512 RefSeq (Proteins) • NP_524236 DDBJ / EMBL / GenBank • AAC46969 AAC46970 AAF52021 AAN17646 AAN17647 AAN17648 AAN17649 AAN17650 AAN17651 AAN17652 AAN17653 AAN17654 AAN17655 AAN17656 AAN17657 AAN17658 AAN17659 AAN17660 AAN17661 AAN17662 AAN17663 AAN17664 AAN17665 AAN17666 AAN17667 AAN17668 ABA86466 AQ026325 AY135094 AY135095 AY135096 AY135097 AY135098 AY135099 AY135100 AY135101 AY135102 AY135103 AY135104 AY135105 AY135106 AY135107 AY135108 AY135109 AY135110 AY135111 AY135112 AY135113 AY135114 AY135115 AY135116 BF505963 CL610106 DQ138860 U43582 U43583 Z83466 Entrez Gene - A searchable database of RefSeq genes. • 40660 UniProtKB/TrEMBL • Q2XY02 Q8I0R4 Q8ISD7 Q8ISD8 Q8ISD9 Q24170 Q24171
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65868 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015402 DroID - A comprehensive database of gene and protein interactions. • FBgn0015402 DRSC - Results from RNAi screens. • FBgn0015402 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015402 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2899-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015402 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40660 InParanoid A subset of ortholog calls from InParanoid. • AAEL008585-PA Aedes aegypti (mosquito) AGAP001482-PA Anopheles gambiae (mosquito) XP_393005.2 Apis mellifera (honey bee) XP_001951609.1 Acyrthosiphon pisum (pea aphid) At3g24550.1 Arabidopsis thaliana (wall cress) 230463 Branchiostoma floridae (lancelet) XP_001896094.1 Brugia malayi (roundworm nematode) BGIBMGA009848-PA Bombyx mori (silk worm) ENSBTAP00000008672 Bos taurus (bovine) CN12235 Caenorhabditis brenneri (small nematode) CBP29367 Caenorhabditis briggsae (nematode) CE25854 Caenorhabditis elegans (worm) ENSCAFP00000014510 Canis familiaris (dog) JA08556 Caenorhabditis japonica (nematode) CPIJ017063 Culex pipens (mosquito) ENSCPOP00000000731 Cavia porcellus (guinea pig) 171767 Chlamidomonas reinhardtii (green alga) RP37087 Caenorhabditis remanei (nematode) 228240 Capitella spl (polychaete worm) 329047 Daphnia pulex (daphnia) ENSDARP00000090579 Danio rerio (zebra fish) ENSECAP00000003395 Equus caballus (horse) ENSGACP00000026826 Gymnopilus aculeatus (mushroom) ENSGALP00000009104 Gallus gallus (chicken) 189079 Hypsipyla robusta (cedar shoot borer) ENSP00000323178 Homo sapiens (human) ISCW017442-PA Ixodes scapularis (deer tick) LmjF16.0870 Leishmania major (virus) ENSMODP00000019181 Monodelphis domestica (gray opossum) ENSMMUP00000023517 Macaca mulatta (rhesus monkey) ENSMUSP00000018478 Mus musculus (house mouse) XP_001605076.1 Nasonia vitripennis (wasp) ENSOANP00000009015 Ornithorynchus anatinus (platypus) ENSORLP00000001306 Oryzias latipes (japanese killifish) PHUM004849-PA Pediculus humanus (human body louse) 183239 Physcomitrella patens (moss) ENSPPYP00000009083 Pongo pygmaeus (orangutan) ENSPTRP00000015183 Pan troglodytes (chimpanzee) ENSRNOP00000038732 Rattus norvegicus (norway rat) 5055190 Sorghum bicolor (sorghum) Smp_037210 Schistosoma mansoni (trematode parasite) 59721 Trichoplax adhaerens (metazoa) XP_001812757.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014789 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029122 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046183 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/kinsras1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40660 modMine - Data generated by the modENCODE project. • FBgn0015402 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15898 NV13823 LH19690 ISCW017442 FBgn0084173 FBgn0213864 FBgn0015212 FBgn0063983 FBgn0165575 JGI_V11_329047 FBgn0075520 FBgn0159754 FBgn0147218 FBgn0126462 FBgn0084866 FBgn0094724 CPIJ017063 BGIBMGA009848 ACYPI006112 GB12129 AGAP001482 AAEL008585 PHUM291680 GLEAN_05910
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG2899 (Barbash et al., 2003, Morrison et al., 2000, Molnar et al., 2006, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dKsr (Jacobs et al., 1999) EK3-1 (Therrien et al., 2000) ksr (Dworkin and Gibson., 2006, Dworkin and Gibson, 2006, Molnar et al., 2006, Cabernard and Affolter, 2005, Sims et al., 2009, Wasbrough et al., 2010, Dworkin et al., 2011) KSR (Sundaram, 2005, Douziech et al., 2003, Huang and Rubin, 2000, Spradling et al., 1999, Baek and Lee, 1999, Hermon et al., 1998, Karim and Rubin, 1998, Douziech et al., 2006, Ashton-Beaucage and Therrien, 2007, Slack et al., 2010, Stark et al., 2011) Ksr (Cork and Purugganan, 2004, Li et al., 2000, Karim et al., 1997, Roignant et al., 2006, Friedman and Perrimon, 2006, Rajakulendran et al., 2009) KSR-1 (Anselmo et al., 2002) Ksr-1 (Downward, 1995) l(3)j5E2 (O'Connor, 2000.1.4, Therrien et al., 1995, BDGP Project Members, 1994-1999, ) SR3-1 (Therrien et al., 1995, )
Name Synonym	Kinase suppressor of Ras (Hermon et al., 1998) kinase suppressor of ras (Dworkin and Gibson, 2006) kinase suppressor of RAS (Douziech et al., 2006) kinase suppressor of Ras85D (Therrien et al., 1995) Suppressor of Ras1 3-1
Secondary FlyBase IDs
	FBgn0011387
References ( 95 )
Generate a list of	All references relating to this gene ( 95 )
List References by type	Research paper  ( 42 ) Supplementary material  ( 7 ) Review  ( 17 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 5 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Stark et al., 2011, Cell. Signal. 23(5): 876--882 Protein kinase CK2 links polyamine metabolism to MAPK signalling in Drosophila. [FBrf0213122] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...