lin19, Cul-1, dCul1, l(2)02074, l(2)k01207
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larval neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (PubMed:20392747). Interacts directly with Roc1a (PubMed:11500045). Interacts with Fsn (PubMed:20123973). Interacts with Dlish (PubMed:27692068). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:27331610). Interacts with Sans (PubMed:27331610).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cul1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cul1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: lin19 l(2)k01207
Renamed from 'lin19' to 'Cul1' to reflect usage in the literature and make the nomenclature of Cullin genes consistent.
Northern analysis reveals lin19 is expressed in all developmental stages with maximal expression on 0-4 hour embryos. In situ hybridisation demonstrates elevated transcription during oogenesis and early embryogenesis. Maternally derived protein is also detected in eggs of virgin females.