lin19, Cul-1, dCul1, lin19-like, l(2)02074
a major component of a series of multimeric ubiquitin ligases that control the degradation of a broad range of proteins
Please see the JBrowse view of Dmel\Cul1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larval neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (PubMed:20392747). Interacts directly with Roc1a (PubMed:11500045). Interacts with Fsn (PubMed:20123973). Interacts with Dlish (PubMed:27692068). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:27331610). Interacts with Sans (PubMed:27331610).
Neddylated (PubMed:12183637, PubMed:18493598). Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:12183637).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cul1 using the Feature Mapper tool.
Comment: moderate expression level; 4-16 hr AEL
Comment: moderate expression level; 1 day APF
Comment: moderate expression level
Cul1 protein is present in the nuclei of all cells, but is preferentially expressed in proliferating tissue.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Cul1 in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: lin19 CG1877
Source for identity of: Cul1 lin19
Source for merge of: lin19 l(2)k01207
Renamed from 'lin19' to 'Cul1' to reflect usage in the literature and make the nomenclature of Cullin genes consistent.
Northern analysis reveals lin19 is expressed in all developmental stages with maximal expression on 0-4 hour embryos. In situ hybridisation demonstrates elevated transcription during oogenesis and early embryogenesis. Maternally derived protein is also detected in eggs of virgin females.