FB2019_06, released Dec 19, 2019

Gene: Dmel\RpS21

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General Information
Symbol
Dmel\RpS21
Species
D. melanogaster
Name
Ribosomal protein S21
Annotation Symbol
CG2986
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015521
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
oho23B, l(2)168/14, l(2)k16814, overgrown hematopoietic organs at 23B, oho23
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:2,856,070..2,857,029 [+]
Recombination map
2-7
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eukaryotic ribosomal protein eS21 family. (O76927)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
ribosome binding; structural constituent of ribosome
Predictions / Assertions
structural constituent of ribosome
Summaries
Gene Group (FlyBase)
CYTOPLASMIC SMALL RIBOSOMAL PROTEINS -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398)
Protein Function (UniProtKB)
May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva.
(UniProt, O76927)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\RpS21 or the JBrowse view of Dmel\RpS21 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RpS21-RA
FBtr0077621
NM_164506
391
83
RpS21-RB
FBtr0077623
NM_164507
619
83
RpS21-RD
FBtr0077622
NM_164508
415
83
RpS21-RE
FBtr0273293
NM_078738
494
81
RpS21-RF
FBtr0335131
NM_001273041
715
83
Additional Transcript Data and Comments
Reported size (kB)
0.7, 0.4 (northern blot)
(Torok et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
RpS21-PA
FBpp0077307
9.2
83
5.69
NP_722853
AAF51191
RpS21-PB
FBpp0077309
9.2
83
5.69
NP_722854
AAN10392
RpS21-PD
FBpp0077308
9.2
83
5.69
NP_722855
AAN10394
RpS21-PE
FBpp0271801
8.9
81
5.69
NP_523462
AAN10393
RpS21-PF
FBpp0307130
9.2
83
5.69
NP_001259970
AGB92507
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

83 aa isoforms: RpS21-PA, RpS21-PB, RpS21-PD, RpS21-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
83 (aa); 9.3 (kD predicted)
(Torok et al., 1999)
Comments
External Data
Subunit Structure (UniProtKB)
Component of the 40S small ribosomal subunit (PubMed:23636399). Interacts with sta (PubMed:10022917).
(UniProt, O76927)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpS21 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
ribosome binding
inferred from physical interaction with UniProtKB:P38979
(assigned by UniProt )
(Torok et al., 1999)
structural constituent of ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
structural constituent of ribosome
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000047682
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
lymph gland development
inferred from mutant phenotype
(Torok et al., 1993)
regulation of cell population proliferation
inferred from mutant phenotype
(assigned by UniProt )
(Torok et al., 1999)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cytoplasmic translation
traceable author statement
(Marygold et al., 2007)
inferred by curator from GO:0022626
(Alonso and Santaren, 2006)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
inferred from biological aspect of ancestor with PANTHER:PTN000047682
(assigned by GO_Central )
(Gaudet et al., 2011)
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
inferred from biological aspect of ancestor with PANTHER:PTN000047682
(assigned by GO_Central )
(Gaudet et al., 2011)
translation
inferred from electronic annotation with InterPro:IPR001931, InterPro:IPR018279
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
ribosome
inferred from direct assay
(assigned by UniProt )
(Torok et al., 1999)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytosolic small ribosomal subunit
inferred from biological aspect of ancestor with PANTHER:PTN000047682
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Marygold et al., 2007)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Torok et al., 1999)
Additional Descriptive Data
oho23B transcripts are expressed fairly uniformly throughout development.
(Torok et al., 1999)
0.7kb oho23B transcripts are expressed at an abundance of less than 5% of the 0.4kb transcripts.
(Torok et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Torok et al., 1999)
Additional Descriptive Data
oho23B protein is relatively uniformly expressed at all developmental stages.
(Torok et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
ribosome
inferred from direct assay
(assigned by UniProt )
(Torok et al., 1999)
Expression Deduced from Reporters
Reporter: P{PZ}RpS2103575
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
imaginal disc
(Meister and Braun, 1995.10)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RpS21 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RpS21
Transgenic constructs containing regulatory region of RpS21
Deletions and Duplications ( 11 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RPS21
13 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rps21
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Rps21
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\rps21
12 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\rps21
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rps-21
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G53890
9 of 9
Yes
Yes
Atha\AT5G27700
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RPS21A
13 of 15
Yes
Yes
Scer\RPS21B
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rps21
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190JZQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\RpS21
Drosophila simulans
Dsim\GD23188
Drosophila sechellia
Dsec\GM18373
Drosophila erecta
Dere\GG24892
Drosophila yakuba
Dyak\GE18186
Drosophila ananassae
Dana\GF14986
Drosophila pseudoobscura pseudoobscura
Dpse\GA15559
Drosophila persimilis
Dper\GL26288
Drosophila willistoni
Dwil\GK24281
Drosophila virilis
Dvir\GJ13417
Drosophila mojavensis
Dmoj\GI19989
Drosophila grimshawi
Dgri\GH25136
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150H33 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015508
Mayetiola destructor
Hessian fly
Mdes\Mdes017165
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004503
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000529
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014189
Anopheles darlingi
American malaria mosquito
Adar\ADAC009121
Anopheles gambiae
Malaria mosquito
Agam\AGAP009431
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001119
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0NPU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001363
Danaus plexippus
Monarch butterfly
Dple\DPOGS211671-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013751
Apis florea
Little honeybee
Aflo\2161155506
Apis mellifera
Western honey bee
Amel\Ame.2195
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13923
Bombus terrestris
Buff-tailed bumblebee
Bter\15215372
Linepithema humile
Argentine ant
Lhum\LH19550
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002ae4
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006851
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12548
Tribolium castaneum
Red flour beetle
Tcas\TC004308
Pediculus humanus
Human body louse
Phum\PHUM001040
Rhodnius prolixus
Kissing bug
Rpro\RPRC004269
Cimex lectularius
Bed bug
Clec\CLEC001398
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085938
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005755
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15527
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0NYL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003771
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67536.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309158
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G113O )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rps21_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rps21
Ciona intestinalis
Vase tunicate
Cint\LOC100175583
Gallus gallus
Domestic chicken
Ggal\RPS21
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    RpS21k16804a
    exacerbates  tauopathy
    modeled by Hsap\MAPTGMR.Ex.PJ
    (Ambegaokar and Jackson, 2011)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RPS21; ribosomal protein S21
    13 of 15
    180477
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        RpS21 - Arc1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - BthD
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG1129
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG11777
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG1218
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG14036
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG14715
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG1532
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG18081
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG18787
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG18789
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG31142
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG6171
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - CG7049
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Ccs
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Fkbp12
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Got1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Hr39
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Hsf
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Rack1
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - Rae1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - RpL10
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL10Ab
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL11
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL12
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL13
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL13A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL14
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL15
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL17
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL18
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL18A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL19
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL21
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL22
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL23
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL23A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL24
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL26
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL27
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL27A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL28
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL29
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL3
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL30
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL31
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL32
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL34a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL35
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL35A
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL36
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL36A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL37A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL37a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL38
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL39
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL4
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL40
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL41
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL5
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL6
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL7
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL7A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL8
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpL9
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpLP0
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpLP1
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpLP2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS10a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS11
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS12
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS13
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS14a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS14b
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS15
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS15Aa
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS16
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS17
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS18
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS19a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS20
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS23
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS24
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS25
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS26
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS27
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS27A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS28b
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS29
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS3
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS30
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS3A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS4
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS5a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS6
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS7
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS8
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - RpS9
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - Sh3β
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Sod1
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Treh
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Trx-2
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - Wdr82
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - awd
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - cib
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - eEF2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - regucalcin
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - sta
        cosedimentation, western blot, pull down, autoradiography, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013, Torok et al., 1999)
        RpS21 - step
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS21 - vig2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS21 - αTry
        experimental knowledge based
        (Guruharsha et al., 2011)
        RNA-protein
        Physical Interaction
        Assay
        References
        RpS21 - 18SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - 28SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - 2SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - 5.8SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS21 - 5SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        RpS21
        enhanceable
        sta
        (Torok et al., 1999)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Bx
        enhanceable
        RpS21
        (Bronstein et al., 2010)
        Pi3K92E
        enhanceable
        RpS21
        (Coelho et al., 2005)
        sta
        enhanceable
        RpS21
        (Torok et al., 1999)
        wg
        suppressible
        RpS21
        (McClure and Schubiger, 2008)
        External Data
        Subunit Structure (UniProtKB)
        Component of the 40S small ribosomal subunit (PubMed:23636399). Interacts with sta (PubMed:10022917).
        (UniProt, O76927 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-7
        Cytogenetic map
        23B5-23B6
        Sequence location
        2L:2,856,070..2,857,029 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        23B5-23B6
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        23B5-23B6
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        23B-23B
        (determined by in situ hybridisation)
        (Herrmann et al., 1995, Torok et al., 1993)
        23B5-23B6
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location
        2-7
        (FlyBase, 2016)
        2-6.5
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (9)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (280)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Torok et al., 1999)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: RpS21 oho23B
        (Torok et al., 1999)
        Source for database merge of
        Additional comments
        Other Comments
        Minute gene.
        (Marygold et al., 2007)
        Deletions removing oho23B but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes.
        (Marygold et al., 2007)
        Molecularly-defined mutations in oho23B result in Minute phenotypes.
        (Marygold et al., 2007)
        oho23B acts as a translation initiation factor, rather than as a core ribosomal protein.
        (Torok et al., 1999)
        Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
        (Roch et al., 1998)
        The tumour suppressor gene oho23B encodes a homologue of the human S21 ribosomal protein.
        (Herrmann et al., 1995)
        Mutants display a blood cell neoplastic phenotype.
        (Mechler, 1994)
        Genetic and developmental characteristics of the lymph gland overgrowth mutant have been determined.
        (Torok et al., 1993)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 66 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Linkouts
        ApoDroso - Functional genomic database for photoreceptor development, survival and function
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (14)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (67)