FlyBase Gene Report: Dmel\tap

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Protein Function (UniProtKB)

May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN.

(UniProt, O16867)

Summary (Interactive Fly)

bHLH transcription factor - Neurogenin/NeuroD homolog - a neural differentiation gene, acting later in the hierarchy of gene activation than the proneural genes - functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\tap or the JBrowse view of Dmel\tap for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

tap-RA

FBtr0075216

NM_079400

2130

398

Additional Transcript Data and Comments

Reported size (kB)

1.392 (longest cDNA)

(Gautier et al., 1997)

2.106 (compiled cDNA)

(Bush et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

tap-PA

FBpp0074978

44.9

398

7.01

NP_524124

AAF49352

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

398 (aa)

(Gautier et al., 1997)

407 (aa)

(Bush et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O16867

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tap using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

tap_1

Linkouts

Gene Ontology (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

axon guidance

inferred from mutant phenotype

(Yuan et al., 2016)

mushroom body development

inferred from mutant phenotype

(Yuan et al., 2016)

negative regulation of axon extension involved in axon guidance

inferred from mutant phenotype

(Yuan et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

regulation of transcription, DNA-templated

inferred from electronic annotation with InterPro:IPR032666

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

sensory organ development

traceable author statement

(Skaer et al., 2002)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

nucleus

inferred from direct assay

(Gautier et al., 1997)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval nervous system | restricted

(Gautier et al., 1997)

presumptive embryonic/larval peripheral nervous system | restricted

(Gautier et al., 1997)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium