FB2021_02, released April 13, 2021

Gene: Dmel\tap

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General Information
Symbol
Dmel\tap
Species
D. melanogaster
Name
target of Poxn
Annotation Symbol
CG7659
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015550
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN. (UniProt, O16867)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

biparous, bps

Key Links
Genomic Location
Cytogenetic map
74A5-74A5
Sequence location
3L:17,359,682..17,361,811 [+]
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17359682..17361811
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001454287
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001454287
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Yuan et al., 2016)
involved_in mushroom body development
inferred from mutant phenotype
(Yuan et al., 2016)
involved_in negative regulation of axon extension involved in axon guidance
inferred from mutant phenotype
(Yuan et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN001454287
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001454287
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sensory organ development
traceable author statement
(Skaer et al., 2002)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Gautier et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001454287
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN.
(UniProt, O16867)
Summary (Interactive Fly)

bHLH transcription factor - Neurogenin/NeuroD homolog - a neural differentiation gene, acting later in the hierarchy of gene activation than the proneural genes - functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\tap for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tap-RA
FBtr0075216
NM_079400
2130
398
Additional Transcript Data and Comments
Reported size (kB)

1.392 (longest cDNA)

(Gautier et al., 1997)

2.106 (compiled cDNA)

(Bush et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
tap-PA
FBpp0074978
44.9
398
7.01
NP_524124
AAF49352
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

398 (aa)

(Gautier et al., 1997)

407 (aa)

(Bush et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tap using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system | restricted
(Gautier et al., 1997)
presumptive embryonic/larval peripheral nervous system | restricted
(Gautier et al., 1997)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 10 -- 11
neuroblast NB4-1
(Bush et al., 1996)
embryonic stage 10 -- 15
larval ventral nerve cord | restricted
(Bush et al., 1996)
embryonic stage 11
neuroblast
(Bush et al., 1996)
embryonic ganglion mother cell
(Bush et al., 1996)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
median neuroblast MNB interneuron
(Kearney et al., 2004)
MP1 neuron
(Kearney et al., 2004)
Additional Descriptive Data

tap is expressed in two clusters of cells in each segment, one dorsal and one ventral that also express Poxn. In contrast to Poxn, it is expressed only at or near the onset of differentiation. The expression is very transient, lasting less than an hour. While Poxn is expressed in most or all of the progeny of a sensory mother cell, tap is expressed in only one cell of each organ. The expression of tap is dependent on Poxn.

(Gautier et al., 1997)

tap transcripts are first observed at stage 10 by in situ hybridization. At that time they are present in 5 cells per segment, one unpaired cell on the midline thought to be the median neuroblast and two pairs lateral to the midline one of which is probably neuroblast 4-1. During germ band extension, there is a large burst of tap expression in the ganglion mother cell (gmc) layer of the ventral nerve cord. An estimated 12-18 cells per hemisegment express tap in the gmc layer. After this, expression is restricted to progressively fe er cells. By stage 14, expression is found in cells at the lateral edge of the CNS. By stage 15, expression is maintained in two large cells per hemisegment. The sites of tap expression do not appear to overlap with elav or repo expression indicating that tap is not expressed in post-mitotic neurons or glia. Some tap-positive cells are synthesizing DNA, suggesting that they are progenitor cells of either neurons or glia.

(Bush et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
v'es2 neuron
(Gautier et al., 1997)
Additional Descriptive Data

Based on a series of double labelling experiments, the site of expression of tap protein in the chemosensory lineage was determined to be the anterior v\'es2 neuron.

(Gautier et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Gautier et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tap in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tap
Transgenic constructs containing regulatory region of tap
Aberrations (Deficiencies and Duplications) ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy | adult stage, with Scer\GAL4Mef2.247
abnormal neuroanatomy | adult stage, with Scer\GAL4tap-Gal4
abnormal neuroanatomy | adult stage | dominant
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | P-stage | dominant
abnormal tarsal response | heat sensitive
majority die during embryonic stage
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
visible, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult mushroom body alpha-lobe | adult stage
adult mushroom body alpha-lobe | adult stage, with Scer\GAL4tap-Gal4
adult mushroom body beta-lobe | adult stage
adult mushroom body beta-lobe | adult stage, with Scer\GAL4Mef2.247
adult mushroom body beta-lobe | adult stage, with Scer\GAL4tap-Gal4
adult mushroom body beta-lobe | adult stage | somatic clone
adult mushroom body beta-lobe | P-stage
axon | adult stage
axon | adult stage, with Scer\GAL4tap-Gal4
axon | adult stage | somatic clone
axon | P-stage
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NEUROG3
9 of 15
Yes
Yes
1  
Hsap\NEUROG1
8 of 15
No
Yes
2  
Hsap\NEUROG2
7 of 15
No
Yes
Hsap\NEUROD2
3 of 15
No
Yes
Hsap\BHLHE22
2 of 15
No
No
1  
Hsap\BHLHE23
2 of 15
No
No
1  
Hsap\NEUROD1
2 of 15
No
Yes
Hsap\NEUROD4
2 of 15
No
Yes
Hsap\NEUROD6
2 of 15
No
Yes
Hsap\OLIG1
2 of 15
No
No
Hsap\OLIG2
2 of 15
No
No
Hsap\OLIG3
2 of 15
No
No
Hsap\ATOH1
1 of 15
No
No
1  
Hsap\ATOH7
1 of 15
No
No
Hsap\ATOH8
1 of 15
No
No
Hsap\ID1
1 of 15
No
No
Hsap\ID2
1 of 15
No
No
1  
Hsap\ID3
1 of 15
No
No
Hsap\ID4
1 of 15
No
No
Hsap\MESP1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Neurog1
9 of 15
Yes
Yes
3  
Mmus\Neurog3
9 of 15
Yes
Yes
Mmus\Neurog2
6 of 15
No
Yes
1  
Mmus\Neurod2
3 of 15
No
Yes
Mmus\Bhlhe22
2 of 15
No
No
Mmus\Bhlhe23
2 of 15
No
No
Mmus\Neurod1
2 of 15
No
Yes
Mmus\Neurod4
2 of 15
No
Yes
1  
Mmus\Neurod6
2 of 15
No
Yes
Mmus\Olig1
2 of 15
No
No
Mmus\Olig2
2 of 15
No
No
Mmus\Olig3
2 of 15
No
No
Mmus\Atoh1
1 of 15
No
No
3  
Mmus\Atoh7
1 of 15
No
No
1  
Mmus\Atoh8
1 of 15
No
No
Mmus\Bhlha15
1 of 15
No
No
Mmus\Id1
1 of 15
No
No
Mmus\Id2
1 of 15
No
No
Mmus\Id3
1 of 15
No
No
Mmus\Id4
1 of 15
No
No
Rattus norvegicus (Norway rat) (18)
Rnor\Neurog1
7 of 13
Yes
Yes
Rnor\Neurog3
7 of 13
Yes
Yes
Rnor\Neurog2
6 of 13
No
Yes
Rnor\Bhlhe22
2 of 13
No
No
Rnor\Bhlhe23
2 of 13
No
No
Rnor\Neurod1
2 of 13
No
Yes
Rnor\Neurod4
2 of 13
No
Yes
Rnor\Neurod6
2 of 13
No
Yes
Rnor\Olig1
2 of 13
No
No
Rnor\Olig2
2 of 13
No
No
Rnor\Olig3
2 of 13
No
No
Rnor\Atoh1
1 of 13
No
No
Rnor\Atoh7
1 of 13
No
No
Rnor\Atoh8
1 of 13
No
No
Rnor\Bhlha15
1 of 13
No
No
Rnor\Id1
1 of 13
No
No
Rnor\Id3
1 of 13
No
No
Rnor\Id4
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\neurog2
6 of 12
Yes
Yes
Xtro\neurog1
5 of 12
No
Yes
Xtro\neurog3
5 of 12
No
Yes
Xtro\neurod1
2 of 12
No
Yes
Xtro\neurod4
2 of 12
No
Yes
Xtro\neurod6
2 of 12
No
Yes
Xtro\olig2
2 of 12
No
No
Xtro\olig3
2 of 12
No
No
Xtro\olig4
2 of 12
No
No
Xtro\atoh1
1 of 12
No
No
Xtro\atoh7
1 of 12
No
No
Xtro\id3
1 of 12
No
No
Xtro\id4
1 of 12
No
No
Xtro\lyl1
1 of 12
No
No
Danio rerio (Zebrafish) (26)
Drer\neurog1
9 of 15
Yes
Yes
Drer\neurog3
7 of 15
No
Yes
Drer\bhlhe22
2 of 15
No
No
Drer\bhlhe23
2 of 15
No
No
Drer\neurod1
2 of 15
No
Yes
Drer\neurod2
2 of 15
No
Yes
Drer\neurod4
2 of 15
No
Yes
Drer\neurod6a
2 of 15
No
Yes
Drer\neurod6b
2 of 15
No
Yes
Drer\olig1
2 of 15
No
No
Drer\olig2
2 of 15
No
No
Drer\olig4
2 of 15
No
No
Drer\si:ch211-196c10.13
2 of 15
No
No
Drer\atoh1a
1 of 15
No
No
Drer\atoh1b
1 of 15
No
No
Drer\atoh1c
1 of 15
No
No
Drer\atoh7
1 of 15
No
No
Drer\atoh8
1 of 15
No
No
Drer\bhlha15
1 of 15
No
No
Drer\hand2
1 of 15
No
No
Drer\id1
1 of 15
No
No
Drer\id2a
1 of 15
No
No
Drer\id2b
1 of 15
No
No
Drer\id3
1 of 15
No
No
Drer\id4
1 of 15
No
No
Drer\olig3
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\ngn-1
7 of 15
Yes
Yes
Cele\cnd-1
2 of 15
No
Yes
Cele\hlh-31
2 of 15
No
No
Cele\hlh-16
1 of 15
No
No
Cele\hlh-17
1 of 15
No
No
Cele\hlh-32
1 of 15
No
No
Cele\Y7A9D.1
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190C4T )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003985
Drosophila simulans
Dsim\GD14703
Drosophila sechellia
Dsec\GM25695
Drosophila erecta
Dere\GG13612
Drosophila yakuba
Dyak\GE19908
Drosophila ananassae
Dana\GF10169
Drosophila pseudoobscura pseudoobscura
Dpse\GA20508
Drosophila persimilis
Dper\GL15578
Drosophila willistoni
Dwil\GK16635
Drosophila virilis
Dvir\GJ12331
Drosophila mojavensis
Dmoj\GI12435
Drosophila grimshawi
Dgri\GH16587
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150476 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023108
Glossina morsitans
Tsetse fly
Gmor\GMOY000753
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07112
Mayetiola destructor
Hessian fly
Mdes\Mdes006264
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014143
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009609
Anopheles gambiae
Malaria mosquito
Agam\AGAP005930
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009873
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BWD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004680
Danaus plexippus
Monarch butterfly
Dple\DPOGS211428-PA
Apis florea
Little honeybee
Aflo\2166397970
Apis mellifera
Western honey bee
Amel\tap
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20044
Bombus terrestris
Buff-tailed bumblebee
Bter\15205987
Linepithema humile
Argentine ant
Lhum\LH21429
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000712
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003992
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06248
Pediculus humanus
Human body louse
Phum\PHUM601720
Rhodnius prolixus
Kissing bug
Rpro\RPRC013552
Cimex lectularius
Bed bug
Clec\CLEC009121
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI37104
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11806
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BU1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010329
Strigamia maritima
European centipede
Smar\SMAR001477
Ixodes scapularis
Black-legged tick
Isca\ISCW020498
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g08200
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g08190
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48108
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0PNH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-N
Ciona intestinalis
Vase tunicate
Cint\neurogenin
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
dimm
3 of 10
net
3 of 10
Oli
3 of 10
amos
2 of 10
ato
2 of 10
cato
1 of 10
sage
1 of 10
tx
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NEUROG3; neurogenin 3
    9 of 15
    604882
     
    NEUROG1; neurogenin 1
    8 of 15
    601726
         
        NEUROG2; neurogenin 2
        7 of 15
        606624
            NEUROD2; neuronal differentiation 2
            3 of 15
            601725
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
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            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            tap - CG31955
            two hybrid array
            (Shokri et al., 2019)
            tap - CG4730
            two hybrid array
            (Shokri et al., 2019)
            tap - Hr78
            two hybrid array
            (Shokri et al., 2019)
            tap - Irbp18
            two hybrid array
            (Shokri et al., 2019)
            tap - Rbsn-5
            two hybrid array
            (Shokri et al., 2019)
            tap - Rel
            two hybrid array
            (Shokri et al., 2019)
            tap - Unr
            two hybrid array
            (Shokri et al., 2019)
            tap - zfh2
            two hybrid array
            (Shokri et al., 2019)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            tap
            enhanceable
            dsh
            (Yuan et al., 2016)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-45
            Cytogenetic map
            74A5-74A5
            Sequence location
            3L:17,359,682..17,361,811 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            74A5-74A5
            Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            74B1-74B5
            (Ledent, 1996.2.16)
            74A-74A
            (Bush, 1997.9.5)
            74B-74B
            (determined by in situ hybridisation)
            (Gautier et al., 1997)
            74B1-74B2
            (determined by in situ hybridisation)
            (Perrimon et al., 1996)
            73D1-73D2
            (determined by in situ hybridisation) 74B1--2 (determined by in situ hybridisation)
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            3-45

            (FlyBase, 2016)

            3-40.6

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (10)
            Genomic Clones (20)
            cDNA Clones (77)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              monoclonal

              (Gautier et al., 1997)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: tap bps

              (Dambly-Chaudiere and Vervoort, 1998)

              Source for merge of: tap bps l(3)01658

              (Ledent et al., 1998)
              Additional comments
              Other Comments

              tap is expressed in a small subset of neurons when they undergo differentiation. In the peripheral nervous system, tap is expressed exclusively in one of the neurons that innervates each larval chemosensory organ, possibly controlling the specific properties of that neuron. Expression of tap is regulated by Poxn.

              (Gautier et al., 1997)

              tap is expressed in both neuronal and glial precursors after they have progressed beyond the ectodermal vs neuronal decision but before they differentiate into mature neurons or glia. Unlike other neural bHLH genes, expression persists until very late stages of embryogenesis.

              (Bush et al., 1996)

              The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. tap gene expression during oogenesis is not critical to embryonic development, but the gene function may be essential for fertilisation and/or completion of meiosis.

              (Perrimon et al., 1996)

              The expression of tap, which encodes a basic HLH protein, is dependent on Poxn.

              (Ledent et al., 1995)
              Origin and Etymology
              Discoverer
              Etymology

              'biparous' means producing two offspring, based on its expression in progenitor cells that give rise to two types of cells.

              (Bush et al., 1996)
              Identification
              External Crossreferences and Linkouts ( 34 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (11)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (76)