FB2021_06, released December 14, 2021

Gene: Dmel\tty

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General Information
Symbol
Dmel\tty
Species
D. melanogaster
Name
tweety
Annotation Symbol
CG1693
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015558
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Summary
Non-essential protein that probably acts as a chloride channel. (UniProt, Q9U6L4)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
19F4-19F5
Sequence location
Recombination map
1-65
RefSeq locus
NC_004354 REGION:21328613..21339676
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables chloride channel activity
inferred from sequence or structural similarity with UniProtKB:Q9C0H2
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from sequence or structural similarity with HGNC:22222
(Suzuki, 2006)
enables intracellular calcium activated chloride channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000965383
(assigned by GO_Central )
(Gaudet et al., 2011)
enables volume-sensitive chloride channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000965383
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in chloride transport
inferred from sequence or structural similarity with HGNC:22222
(Suzuki, 2006)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR006990
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence model
(Suzuki, 2006)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000965383
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from sequence or structural similarity with UniProtKB:Q9C0H2
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the tweety family. (Q9U6L4)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TWEETY FAMILY -
The Tweety family encode putative large-conductance chloride channels. Tweety proteins are predicted to possess five or six transmembrane domains. (Adapted from FBrf0192351).
Protein Function (UniProtKB)
Non-essential protein that probably acts as a chloride channel.
(UniProt, Q9U6L4)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\tty for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tty-RA
FBtr0077224
NM_080712
3927
970
tty-RC
FBtr0329900
NM_001272838
3078
542
tty-RD
FBtr0329901
NM_167744
7199
970
tty-RE
FBtr0329902
NM_001272839
3853
966
tty-RF
FBtr0329903
NM_001272840
6642
966
tty-RG
FBtr0333749
NM_001272837
3757
967
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
tty-PA
FBpp0076919
105.8
970
8.19
NP_542443
AAF50831
tty-PC
FBpp0302934
59.7
542
8.77
NP_001259767
AGB95605
tty-PD
FBpp0302935
105.8
970
8.19
NP_728415
AAN09675
tty-PE
FBpp0302936
105.4
966
8.19
NP_001259768
AGB95606
tty-PF
FBpp0302937
105.4
966
8.19
NP_001259769
AGB95607
tty-PG
FBpp0305891
105.5
967
8.19
NP_001259766
AGB95604
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

970 aa isoforms: tty-PA, tty-PD
966 aa isoforms: tty-PE, tty-PF
Additional Polypeptide Data and Comments
Reported size (kDa)

836 (aa)

(Maleszka et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tty using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tty in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tty
Transgenic constructs containing regulatory region of tty
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TTYH3
13 of 15
Yes
Yes
1  
Hsap\TTYH1
12 of 15
No
Yes
Hsap\TTYH2
12 of 15
No
Yes
Hsap\PVRIG
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ttyh1
12 of 15
Yes
Yes
Mmus\Ttyh2
12 of 15
Yes
Yes
Mmus\Ttyh3
12 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Ttyh1
10 of 13
Yes
Yes
Rnor\Ttyh3
10 of 13
Yes
Yes
Rnor\Ttyh2
7 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\ttyh1
11 of 12
Yes
Yes
Xtro\ttyh2
10 of 12
No
Yes
Xtro\ttyh3
9 of 12
No
Yes
Xtro\cbx8
1 of 12
No
No
Danio rerio (Zebrafish) (5)
Drer\ttyh3b
13 of 15
Yes
Yes
Drer\ttyh2
12 of 15
No
Yes
Drer\ttyh2l
11 of 15
No
Yes
Drer\ttyh1
10 of 15
No
Yes
Drer\ttyh3a
10 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ttyh-1
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903R4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004819
Drosophila simulans
Dsim\GD28650
Drosophila sechellia
Dsec\GM22627
Drosophila erecta
Dere\GG17543
Drosophila yakuba
Dyak\GE15303
Drosophila ananassae
Dana\GF22440
Drosophila pseudoobscura pseudoobscura
Dpse\GA14222
Drosophila persimilis
Dper\GL19902
Drosophila willistoni
Dwil\GK19929
Drosophila virilis
Dvir\GJ19022
Drosophila mojavensis
Dmoj\GI15862
Drosophila grimshawi
Dgri\GH12408
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915063V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024262
Glossina morsitans
Tsetse fly
Gmor\GMOY008246
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08561
Mayetiola destructor
Hessian fly
Mdes\Mdes005224
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010941
Anopheles darlingi
American malaria mosquito
Adar\ADAC000562
Anopheles gambiae
Malaria mosquito
Agam\AGAP000860
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003195
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003194
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BMV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007141
Danaus plexippus
Monarch butterfly
Dple\DPOGS210825-PA
Apis florea
Little honeybee
Aflo\3328217188
Apis mellifera
Western honey bee
Amel\LOC413358
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21671
Bombus terrestris
Buff-tailed bumblebee
Bter\15209579
Linepithema humile
Argentine ant
Lhum\LH21393
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001276
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004462
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12717
Tribolium castaneum
Red flour beetle
Tcas\TC033993
Pediculus humanus
Human body louse
Phum\PHUM092770
Rhodnius prolixus
Kissing bug
Rpro\RPRC009248
Rhodnius prolixus
Kissing bug
Rpro\RPRC009251
Rhodnius prolixus
Kissing bug
Rpro\RPRC009249
Cimex lectularius
Bed bug
Clec\CLEC000389
Cimex lectularius
Bed bug
Clec\CLEC000389-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002050
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05030
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BKH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015255
Ixodes scapularis
Black-legged tick
Isca\ISCW015482
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79975.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g01240
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314365
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0IBL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\LOC100183845
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG3638
6 of 10
CG14540
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TTYH3; tweety family member 3
    13 of 15
    608919
         
        TTYH1; tweety family member 1
        12 of 15
        605784
            TTYH2; tweety family member 2
            12 of 15
            608855
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                X
                Recombination map
                1-65
                Cytogenetic map
                19F4-19F5
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                19F4-19F5
                Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                19F-19F
                (determined by in situ hybridisation)
                (Campbell et al., 1993)
                Deduced from proximity to fliI.
                (Campbell et al., 1993)
                Experimentally Determined Recombination Data
                Location

                1-65

                (FlyBase, 2016)

                1-66.0

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (3)
                Genomic Clones (9)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (30)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: tty CG1693

                  (Li, 1999.11)
                  Source for database merge of
                  Additional comments
                  Other Comments

                  Defined as a transcription unit during the molecular analysis of the nearby fliI gene.

                  (Campbell et al., 1993)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 51 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (5)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (39)