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Gene Dmel\tty

General Information
Symbol	Dmel\tty	Species	D. melanogaster
Name	tweety	Annotation symbol	CG1693
Feature type	protein_coding_gene	FlyBase ID	FBgn0015558
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	19F4-19F5	Sequence location	X:21,199,695..21,210,649 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tweety is referred to in FlyBase by the symbol Dmel\tty (CG1693, FBgn0015558). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Tweety. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is X:21199695..21210649.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 19F4-19F5   Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
Experimentally Determined Cytological Location
Cytogenetic map Notes References 19F-19F   Deduced from proximity to fliI. (determined by in situ hybridisation)   (Campbell et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tty for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tty-RA FBtr0077224  NM_080712   3927   970 tty-RC FBtr0329900  NM_001272838   3078   542 tty-RD FBtr0329901  NM_167744   7199   970 tty-RE FBtr0329902  NM_001272839   3799   966 tty-RF FBtr0329903  NM_001272840   6587   966 tty-RG FBtr0333749  NM_001272837   3763   967
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tty-PA   FBpp0076919   105.8   970   8.19     NP_542443   AAF50831 tty-PC   FBpp0302934   59.7   542   8.77     NP_001259767   AGB95605 tty-PD   FBpp0302935   105.8   970   8.19     NP_728415   AAN09675 tty-PE   FBpp0302936   105.4   966   8.19     NP_001259768   AGB95606 tty-PF   FBpp0302937   105.4   966   8.19     NP_001259769   AGB95607 tty-PG   FBpp0305891   105.5   967   8.19     NP_001259766   AGB95604
Additional Polypeptide Data & Comments
Reported size (kDa)	836 (aa) (Maleszka et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tweety (IPR006990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA817525   AE014298 AAF50831   AE014298 AAN09675   AC011251   AF017777 AAC28400   AF184227 AAD55738   AE014298 AGB95604   AE014298 AGB95605   AE014298 AGB95606   AE014298 AGB95607   AI297991   AI457089   BI228672   CK657012   CK657721   CO177096   CO188683   CO264117   CO279317   CO282960   CO286996   CO288818   CO296592   CO303390   CO307813   CO315093   CO344872   EC051869   EC051946   EC051968   EC053481   EC055527   EC062140   EC080681   EC082203   EC195128   EC195244   EC197211   EC201742   EC214467   EC218522   EC221176   EC225950   EC231310   EC241567   EC241836   EC242087   EC244590   EC249468   EC252273   GH941300   GH942267   GH942764   GH943747   GH944584   GH944815   GH945074   GH946264   GH946513   GH946586   GH947048   GH947456   GH948051   GH948236   GH948857   GH949348   GH950866   GH952214   GH953445   GH953879   GH953904   GH955159   GH956257   GH956867   GH957505   GH958267   GH958868   GH961857   GH962657   GH963264   GH965710   GH966145   GH967674   GH968477   GH969388   GH971063   GH972068   GH973363   GH973901   GH976502   GH977916   GH978143   GH979286   GH980001   GH980876   GH982823
UniProtKB/Swiss-Prot	Q9U6L4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    75 central nervous system, pupae P8    113 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    36 head, mated 4-day male    35 head, mated 20-day male    28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3  (75) central nervous system, pupae P8  (113) head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male  (36) head, mated 4-day male  (35) head, mated 20-day male  (28) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    75 central nervous system, pupae P8  (113) head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    36 head, mated 4-day male    35 head, mated 20-day male    28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    75 central nervous system, pupae P8    113 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    36 head, mated 4-day male    35 head, mated 20-day male    28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    75 central nervous system, pupae P8    113 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    36 head, mated 4-day male    35 head, mated 20-day male    28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3  (75) central nervous system, pupae P8  (113) head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male  (36) head, mated 4-day male  (35) head, mated 20-day male  28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    75 central nervous system, pupae P8  113 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    36 head, mated 4-day male    35 head, mated 20-day male    28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    75 central nervous system, pupae P8    113 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    15 head, mated 1-day female    24 head, mated 4-day female    18 head, mated 20-day female    15 head, mated 1-day male    36 head, mated 4-day male    35 head, mated 20-day male    28 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    9 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    8 embryo 04-06hr    16 embryo 06-08hr    17 embryo 08-10hr    11 embryo 10-12hr    9 embryo 12-14hr    12 embryo 14-16hr    16 embryo 16-18hr    18 embryo 18-20hr    22 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    19 larva L2    8 larva L3 12hr old    4 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    14 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    3 embryonic S1    1 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    15 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015558 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1693-RB;CG1693-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 ttyGD3710 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of tty Class Mutagen Stocks Known lesion ttyc03142 1 -- ttyBG00350 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tty Class Mutagen Stocks Known lesion ttyGD3710 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ttyKK101659 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ttytMa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)16-129 (Maleszka et al., 1996) Df(1)17-257 (Maleszka et al., 1996) Df(1)GA104 (Maleszka et al., 1996)
Not disrupted in	Df(1)2/19B (Maleszka et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3710} NA P{KK101659} NA characterization construct P{FLI10.2} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP1304 NA miscellaneous insertions P{GT1}ttyBG00350 NA PBac{PB}ttyc03142 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a biological process term for this gene. (Based on a review of available data on: 2008-03-20)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tty allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0015558 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33109
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JT0R8 Dipteran inclusive ortholog search EOG6FXRGN Insect inclusive ortholog search EOG66DK07 Arthropod inclusive ortholog search EOG659ZZ1 Metazoa inclusive ortholog search EOG6N3CHX
Orthologs in Drosophila Species (EOG6JT0R8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tty     Drosophila sechellia   Dsec\GM22627 Y   Drosophila erecta   Dere\GG17543 Y   Drosophila yakuba   Dyak\GE15303 Y   Drosophila ananassae   Dana\GF22440 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14222 Y   Drosophila persimilis   Dper\GL19902 Y   Drosophila willistoni   Dwil\GK19929 Y   Drosophila virilis   Dvir\GJ19022 Y   Drosophila mojavensis   Dmoj\GI15862 Y   Drosophila grimshawi   Dgri\GH12408 Y
Orthologs in non-Drosophila Dipterans (EOG6FXRGN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011800 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010941 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002924 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000860 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014119 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003194 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ020059 Y
Orthologs in non-Dipteran Insects (EOG66DK07)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413358 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004462 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17234 Y Atta cephalotes Leafcutter ant  Acep\ACEP27817 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13429 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13131 Y Linepithema humile Argentine ant  Lhum\LH21393 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB21197 Y Solenopsis invicta Red fire ant  Sinv\SINV25946 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002050 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007141 Y Pediculus humanus Human body louse  Phum\PHUM092770 Y Tribolium castaneum Red flour beetle  Tcas\TC006204 Y
Orthologs in non-Insect Arthropods (EOG659ZZ1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ddc Y Ixodes scapularis Deer tick  Isca\ISCW015482 Y
Orthologs in non-Arthropod Metazoa (EOG6N3CHX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ttyh-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007588gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM22627 Drosophila erecta Dere\GG17543 Drosophila yakuba Dyak\GE15303 Drosophila ananassae Dana\GF22440 Drosophila pseudoobscura pseudoobscura Dpse\GA14222 Drosophila persimilis Dper\GL19902 Drosophila willistoni Dwil\GK19929 Drosophila virilis Dvir\GJ19022 Drosophila mojavensis Dmoj\GI15862 Drosophila grimshawi Dgri\GH12408
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{PB}ttyc03142
VDRC	v43841 w1118; P{GD3710}v43841 v43843 w1118; P{GD3710}v43843
Genomic Clones ( 1 )
	BACR09F10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 85 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23194
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP08357 LP22937 LP24240 RE26292
Other clones	19990 28758 45728 80978 119541 121445 149476 214475.67 CK01.35C.G1 CK01.44A.B4 CK01.49B.F8 CK01.64A.G2 CK01.64C.F4 CK01.77B.E12 CK01.88A.H7 CK01.106D.G3 CK01.123D.E11 EC051869 EC051946 EC051968 EC053481 EC055527 EK041456 EK052441 EK064543 EK069432 EK134030 EK137529 EK161850 EK214258 EK239017 EK241237 EK255753 EP20107 RP004020400 RP004038774 RP004058127 RP004070142 RP004082580 RP004102753 RP004122327 RP004122785 RP004129189 RP004147715 RP004167478 RP004186485 RP004193340 RP004201182 RP004202122 RP004209417 RP004213395 RP004216213 RP004218749 RP004219604 RP004223157 RP004233567 RP004236047 RP004236227 RP004239328 RP004244236 RP004247453 RP004252307 RP004257709 RP004258491 RP004262928 RP004269564 RP004273035 RP004317890 RP004373416 RP004382360 RP004403072 RP004418447 RP004442262 RP004454346 RP004464485 RP004482649 RP004489364 RP004516123 RP004523633 RP004531169
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015558 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33109
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tty CG1693 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Defined as a transcription unit during the molecular analysis of the nearby fliI gene. (Campbell et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080712 NM_167744 NM_001272837 NM_001272838 NM_001272839 NM_001272840 RefSeq (Proteins) • NP_542443 NP_728415 NP_001259766 NP_001259767 NP_001259768 NP_001259769 DDBJ / EMBL / GenBank • AA817525 AAC28400 AAD55738 AAF50831 AAN09675 AC011251 AF017777 AF184227 AGB95604 AGB95605 AGB95606 AGB95607 AI457089 Entrez Gene - A searchable database of RefSeq genes. • 33109 UniProtKB/Swiss-Prot • Q9U6L4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tweety (IPR006990)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0015558 DRSC - Results from RNAi screens. • FBgn0015558 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015558 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1693-RB;CG1693-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015558 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33109 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33109 modMine - Data generated by the modENCODE project. • FBgn0015558
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG1693 (Mount and Mookherjee, 2000.12.14, Keleman et al., 2009.8.5) tty (Levis et al., 2011.12.16, Buffin and Gho, 2010, Jumbo-Lucioni et al., 2010) twe (Maleszka et al., 1996)
Name Synonym	tweety (Campbell et al., 1993, Buffin and Gho, 2010)
Secondary FlyBase IDs
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...