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Gene Dmel\dare

General Information
Symbol	Dmel\dare	Species	D. melanogaster
Name	defective in the avoidance of repellents	Annotation symbol	CG12390
Feature type	protein_coding_gene	FlyBase ID	FBgn0015582
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	AR
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	47F1-47F1	Sequence location	2R:7,178,499..7,180,676 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene defective in the avoidance of repellents is referred to in FlyBase by the symbol Dmel\dare (CG12390, FBgn0015582). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: electron carrier activity; NADPH-adrenodoxin reductase activity. There is experimental evidence that it is involved in the biological process: olfactory behavior; steroid biosynthetic process; metamorphosis; molting cycle, chitin-based cuticle; pupariation. 12 alleles are reported. The phenotypes of these alleles are annotated with: thoracico-abdominal ganglion; fan-shaped body; optic lobe; embryonic/larval anterior spiracle; antennal lobe; egg chamber; ellipsoid body; mouth hooks. It has one annotated transcript and one annotated polypeptide. Protein features are: Ferredoxin-NADP (+) reductase; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1636137_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dare. Gene sequence location is 2R:7178499..7180676.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN46089 HFA07602 BKN22443
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47F1-47F1   Limits computationally determined from genome sequence between P{PZ}rM547 and P{lacW}Fppsk06103&P{lacW}Fppsk03514
Experimentally Determined Cytological Location
Cytogenetic map Notes References 47E-47E     (Freeman, 1999.7.13) 47E-47E   (determined by in situ hybridisation)   (Freeman et al., 1999) 47E-47E   (determined by in situ hybridisation)   (Freeman et al., 1997) 47E-47E     (Freeman and Carlson, 1996)
Experimentally Determined Recombination Data
Location	2- (Freeman and Carlson, 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dare for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dare-RA FBtr0088176  NM_057802   1678   466
Additional Transcript Data & Comments
Reported size (kB)	1.634 (longest cDNA) (Freeman et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dare-PA   FBpp0087272   51.4   466   8.56     NP_477150   AAF58678
Additional Polypeptide Data & Comments
Reported size (kDa)	466 (aa); 55 (kD observed) (Freeman et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • NAD(P)-binding domain (IPR016040) Ferredoxin-NADP (+) reductase (IPR021163) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12390
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539167   AE013599 AAF58678   AC006066   AF168685 AAD50819   AW942445   AY061230 AAL28778   BI173968   BI351832   BI352627   BI369606   BI369825   BI374545   BI484444   BI579077   BT001566 AAN71321   BT083432   EC247171   GH741926   GH743908   GH744504   GH765198   GH766931   GH768259   GH768761   GH769782   GH779572   GO254491
UniProtKB/Swiss-Prot	Q9V3T9
UniProtKB/TrEMBL	Q8IGW0 Q95RP7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   ring gland   (Freeman et al., 1999) prothoracic gland   (Freeman et al., 1999) adult stage   ovary   (Freeman et al., 1999)   (Freeman et al., 1999) adult stageoogenesis stage S6 -- S14   nurse cell   (Freeman et al., 1999)
Additional Descriptive Data
	dare transcripts are detected in the third instar larval prothoracic gland, and in the adult ovary. Expression in the ovary is limited to nurse cells, and begins at stage 6-7 of oogenesis. Low levels of expression are detected in various adult tissues by in situ hybridization, RT-PCR and RNAse protection experiments. (Freeman et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	dare protein is detected in the mitochondrial fraction of Drosophila head extracts. (Freeman et al., 1999)
Marker for
Subcellular Localization
CV Term	mitochondrion (Freeman et al., 1999)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015582    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015582 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015582 expression level Developmental Stage   Expression Level embryo 00-02hr    2475 embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr    1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2    1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day    1775 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2475) embryo 02-04hr  (278) embryo 04-06hr  (380) embryo 06-08hr  (734) embryo 08-10hr  (791) embryo 10-12hr  (1401) embryo 12-14hr  (1110) embryo 14-16hr  (1063) embryo 16-18hr  (796) embryo 18-20hr  (550) embryo 20-22hr  (509) embryo 22-24hr  (475) larva L1  (1114) larva L2  (1619) larva L3 12hr old  (1234) larva L3 puffstage 1-2  (1115) larva L3 puffstage 3-6  (1026) larva L3 puffstage 7-9  (1211) white prepupae new  (1112) white prepupae 12hr  (719) white prepupae 24hr  (844) pupae 2d postWPP  (1089) pupae 3d postWPP  (668) pupae 4d postWPP  (626) adult male 01day  (713) adult male 05day  (662) adult male 30day  (757) adult female 01day  (1339) adult female 05day  (1775) adult female 30day  (2065) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2475) embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr  1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2  (1619) larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day  (1775) adult female 30day  (2065) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2475 embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr    1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2    1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day    1775 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2475 embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr    1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2    1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day    1775 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015582 expression level Developmental Stage   Expression Level embryo 00-02hr    2475 embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr    1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2    1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day    1775 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2475) embryo 02-04hr  (278) embryo 04-06hr  (380) embryo 06-08hr  (734) embryo 08-10hr  (791) embryo 10-12hr  (1401) embryo 12-14hr  (1110) embryo 14-16hr  (1063) embryo 16-18hr  (796) embryo 18-20hr  (550) embryo 20-22hr  (509) embryo 22-24hr  (475) larva L1  (1114) larva L2  (1619) larva L3 12hr old  (1234) larva L3 puffstage 1-2  (1115) larva L3 puffstage 3-6  (1026) larva L3 puffstage 7-9  (1211) white prepupae new  (1112) white prepupae 12hr  (719) white prepupae 24hr  (844) pupae 2d postWPP  (1089) pupae 3d postWPP  (668) pupae 4d postWPP  (626) adult male 01day  (713) adult male 05day  (662) adult male 30day  (757) adult female 01day  (1339) adult female 05day  (1775) adult female 30day  (2065) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2475) embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr  1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2  1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day  1775 adult female 30day  2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2475 embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr    1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2    1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day    1775 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2475 embryo 02-04hr    278 embryo 04-06hr    380 embryo 06-08hr    734 embryo 08-10hr    791 embryo 10-12hr    1401 embryo 12-14hr    1110 embryo 14-16hr    1063 embryo 16-18hr    796 embryo 18-20hr    550 embryo 20-22hr    509 embryo 22-24hr    475 larva L1    1114 larva L2    1619 larva L3 12hr old    1234 larva L3 puffstage 1-2    1115 larva L3 puffstage 3-6    1026 larva L3 puffstage 7-9    1211 white prepupae new    1112 white prepupae 12hr    719 white prepupae 24hr    844 pupae 2d postWPP    1089 pupae 3d postWPP    668 pupae 4d postWPP    626 adult male 01day    713 adult male 05day    662 adult male 30day    757 adult female 01day    1339 adult female 05day    1775 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015582    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015582 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015582 expression level Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015582 expression level Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    49.15 Larval Midgut    118.1 Larval Hindgut    66.3 Larval Malpighian Tubules    93 Larval Fat Body    57.7 Larval Salivary Gland    86.1 Larval Trachea    60.1 Larval Carcass    66.125 Adult Head    39.6 Adult Eye    32.025 Adult Brain    92.2 Adult Thoracic-Abdominal Ganglion    66.6 Adult Crop    44.8 Adult Midgut    95.9 Adult Hindgut    69.4 Adult Malpighian Tubules    101 Adult Fat Body    74.3 Adult Salivary Gland    50.7 Adult Heart    61.025 Adult VirginFemale Spermatheca    47.9 Adult InseminatedFemale Spermatheca    51 Adult Ovary    151.5 Adult Testis    16.2 Adult Male Accessory Gland    31.2 Adult Carcass    64.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    39.6   NA  Eye    32.025   NA  Brain    92.2   49.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    66.6   NA  Crop    44.8   118.1  Midgut    95.9   66.3  Hindgut    69.4   93  Malpighian Tubules    101   57.7  Fat Body    74.3   86.1  Salivary Gland    50.7   NA  Heart    61.025   60.1  Trachea    NA   NA  VirginFemale Spermatheca    47.9   NA  InseminatedFemale Spermatheca    51   NA  Ovary    151.5   NA  Testis    16.2   NA  Male Accessory Gland    31.2   66.125  Carcass    64.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015582 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12390-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | dominant | maternal effect dare5 lethal | embryonic stage | recessive dare5 lethal | larval stage | recessive dare34 dare102 lethal | recessive dare4 dare5 viable dare1 dare3 viable, with Scer\GAL4pnr-MD237 dareGD7711 Other Phenotypes Allele behavior defective dare1 courtship behavior defective | male dare1 smell perception defective | recessive dare1 dare3 wild-type dare+tGF darehs.PF Phenotype manifest in Allele antennal lobe dare34 dare4 dare5 egg | germline clone dare34 egg chamber dare5 ellipsoid body dare34 dare4 dare5 embryonic/larval anterior spiracle dare102 fan-shaped body dare34 dare4 dare5 mouth hooks dare102 optic lobe dare34 dare4 dare5 thoracico-abdominal ganglion dare34 dare4 dare5
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of dare Class Mutagen Stocks Known lesion dare102 Delta2-3 0 Yes dare1 P-element activity 0 Yes dare34 Delta2-3 0 Yes dare3 Delta2-3 0 Yes dare4 Delta2-3 0 Yes dare5 P-element activity Delta2-3 0 Yes darerv2 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dare Class Mutagen Stocks Known lesion dareGD7711 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dareJF03171 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dare+tGF in vitro construct - genomic fragment 0 Yes darehs.PF in vitro construct - regulatory fusion 0 Yes dareKK102377 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Ab(2;?)dare34 (Freeman et al., 1999) Df(2R)dare4 (Freeman et al., 1999) Df(2R)Exel6060 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3497} NA P{GD7711} NA P{KK102377} NA P{TRiP.JF03171} NA heat-shock construct P{hs-dare.F} NA characterization construct P{dare+tGF} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}dare1 No miscellaneous insertions P{?lacW}dare3 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
metamorphosis inferred from mutant phenotype (Freeman et al., 1999) molting cycle, chitin-based cuticle inferred from mutant phenotype (Freeman et al., 1999) olfactory behavior inferred from mutant phenotype (Freeman et al., 1999) pupariation inferred from mutant phenotype (Freeman et al., 1999) steroid biosynthetic process inferred from direct assay (Freeman et al., 1999) inferred from expression pattern (Freeman et al., 1999)
Cellular Component
CV term Evidence References
mitochondrion inferred from direct assay (Freeman et al., 1999)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from sequence or structural similarity with UniProtKB:P22570 (Sardiello et al., 2003.6.11) non-traceable author statement (Freeman, 1999.7.13) ferredoxin-NADP+ reductase activity non-traceable author statement (Freeman, 1999.7.13) NADPH-adrenodoxin reductase activity inferred from sequence or structural similarity with UniProtKB:P22570 (Sardiello et al., 2003.6.11) inferred from sequence or structural similarity with UniProtKB:P56522 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) nucleotide binding inferred from electronic annotation with InterPro:IPR016040 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cholesterol catabolic process inferred from sequence or structural similarity with UniProtKB:P22570 (Sardiello et al., 2003.6.11) courtship behavior non-traceable author statement (Steadele et al., 1999) molting cycle, chitin-based cuticle non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) olfactory behavior non-traceable author statement (Freeman et al., 1998, Swiss-Prot Project Members, 2000.10.1) oxidation-reduction process inferred from electronic annotation with InterPro:IPR021163 (FlyBase Curators et al., 2004-) pheromone metabolic process non-traceable author statement (Freeman et al., 1998, Steadele et al., 1999) phototaxis non-traceable author statement (Freeman et al., 1998) steroid biosynthetic process non-traceable author statement (Freeman et al., 1998, Swiss-Prot Project Members, 2000.10.1)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from sequence or structural similarity with UniProtKB:P22570 (Sardiello et al., 2003.6.11) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) mitochondrion non-traceable author statement (Freeman, 1999.7.13)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dare allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0015582 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36203
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12417 Dere\GG22675 Dgri\GH21932 Dmoj\GI19640 Dper\GL16741 Dpse\GA11603 Dsec\GM20453 Dsim\GD25921 Dvir\GJ15006 Dwil\GK21620 Dyak\GE13030
Curated drosophilid orthologs	Dpse\GA11603
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006733-PA Aedes aegypti (mosquito) AGAP005419-PA Anopheles gambiae (mosquito) XP_001948763.1 Acyrthosiphon pisum (pea aphid) At4g32360.1 Arabidopsis thaliana (wall cress) 26930 Batrachochytrium dendrobatidis (chytrid fungus) 88012 Branchiostoma floridae (lancelet) XP_001902428.1 Brugia malayi (roundworm nematode) ENSBTAP00000034569 Bos taurus (bovine) CN19081 Caenorhabditis brenneri (small nematode) CBP28348 Caenorhabditis briggsae (nematode) CE24542 Caenorhabditis elegans (worm) ENSCAFP00000006917 Canis familiaris (dog) CAGL0A03014g Candida glabrata (haploid yeast) ENSCINP00000003883 Ciona intestinalis (sea squirt) JA16021 Caenorhabditis japonica (nematode) CMM294C Cyanidioschyzon merolae (red alga) cn09101 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000016728 Cavia porcellus (guinea pig) 113649 Chlamidomonas reinhardtii (green alga) RP39233 Caenorhabditis remanei (nematode) ENSCSAVP00000001632 Ciona savignyi (sedentary tunicate) DDB0234047 Dictyostelium discoideum (amoeba) DEHA2D18216g Debaryomyces Hansenii (yeast) 307619 Daphnia pulex (daphnia) ENSDARP00000089699 Danio rerio (zebra fish) ENSECAP00000007578 Equus caballus (horse) ENSGACP00000006923 Gymnopilus aculeatus (mushroom) ENSGALP00000012569 Gallus gallus (chicken) 156059 Hypsipyla robusta (cedar shoot borer) ENSP00000293195 Homo sapiens (human) ISCW020877-PA Ixodes scapularis (deer tick) KLLA0E02531g Kluyveromyces lactis (yeast) 229321 Lottia gigantea (owl limpet) LmjF21.0420 Leishmania major (virus) 16315 Monocosta brevicollis (choanoflagellate) ENSMODP00000008606 Monodelphis domestica (gray opossum) ENSMMUP00000020532 Macaca mulatta (rhesus monkey) ENSMUSP00000021078 Mus musculus (house mouse) 93833 Nematostella vectensis (starlet anemone) ENSOANP00000019899 Ornithorynchus anatinus (platypus) ENSORLP00000025246 Oryzias latipes (japanese killifish) LOC_Os02g17700.1 Oryza sativa (asian rice) 36247 Ostreococcus tauri (green alga) PF11_0407 Plasmodium falciparum (protozoal parasite) PHUM000034-PA Pediculus humanus (human body louse) PP03471 Pristionchus pacificus (nematode) 224842 Physcomitrella patens (moss) ENSPPYP00000009667 Pongo pygmaeus (orangutan) 71984 Phytophthora ramorum (sudden oak death pathogen) 108178 Phytophthora sojae (root rot pathogen) 830556 Populus trichocarpa (black cottonwood) ENSPTRP00000016347 Pan troglodytes (chimpanzee) PVX_092585 Plasmodium vivax (protozoal parasite) PVX_202290 Plasmodium vivax (protozoal parasite) ENSRNOP00000004592 Rattus norvegicus (norway rat) 5055033 Sorghum bicolor (sorghum) YDR376W Saccharomyces cerevisiae (budding yeast) Smp_166580 Schistosoma mansoni (trematode parasite) SPBC3B8.01c Schizosaccharomyces pombe (fission yeast) XP_001192852.1 Strongylocentrotus purpuratus (purple sea urchin) 21502 Trichoplax adhaerens (metazoa) XP_970322.1 Tribolium castaneum (red flour beetle) Tc00.1047053511367.230 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022643 Tetraodon nigroviridis (green spotted pufferfish) 10895 Thalassiosira pseudonana (marine diatom) ENSTRUP00000020417 Takifugu rubripes (pufferfish Takifugu) 3686.m00956 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000014989 Xenopus tropicalis (frog) YALI0B14839g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11855 NV50160 LH18869 ISCW020877 FBgn0230736 FBgn0223612 FBgn0202206 FBgn0197199 FBgn0186923 FBgn0175335 JGI_V11_307619 FBgn0071654 FBgn0154345 FBgn0142377 FBgn0129393 FBgn0114840 FBgn0089454 ACYPI004683 GB17540 AGAP005419 AAEL006733 AAEL005990 PHUM454900 GLEAN_14987
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28743 y1 v1; P{TRiP.JF03171}attP2
VDRC	v38682 w1118; P{GD7711}v38682 v38683 w1118; P{GD7711}v38683
Genomic Clones ( 2 )
	BACR09B12 BACR29G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD17269 RE17125
Other clones	FI04471
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM16292 GM20127 RE55840 RE56136 RE62165 RE67547 RE73050
Other clones	73854 RP01380 RP001011140 RP001014941 RP001024863 RP001025262 RP001032652 RP001040858 RP001049611 RP001050418 RP001050806
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36203
Antibody Information
	polyclonal (Freeman et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Null mutants in dare undergo developmental arrest during the second larval instar stage or at the second larval moult and mutants of intermediate severity are delayed in pupariation. Mild reductions in dare expression cause abnormal behavioural responses to olfactory stimuli. dare mutations of intermediate strength result in rapid, widespread degeneration of the adult nervous system. (Freeman et al., 1999) Mutant allele show abnormal olfactory behavior. (Freeman and Carlson, 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057802 RefSeq (Proteins) • NP_477150 DDBJ / EMBL / GenBank • AA539167 AAD50819 AAF58678 AAL28778 AAN71321 AC006066 AF168685 AW942445 AY061230 BI173968 BT001566 Entrez Gene - A searchable database of RefSeq genes. • 36203 UniProtKB/Swiss-Prot • Q9V3T9 UniProtKB/TrEMBL • Q8IGW0 Q95RP7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • NAD(P)-binding domain (IPR016040) Ferredoxin-NADP (+) reductase (IPR021163) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12390
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0015582 DRSC - Results from RNAi screens. • FBgn0015582 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015582 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12390-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36203 InParanoid A subset of ortholog calls from InParanoid. • AAEL006733-PA Aedes aegypti (mosquito) AGAP005419-PA Anopheles gambiae (mosquito) XP_001948763.1 Acyrthosiphon pisum (pea aphid) At4g32360.1 Arabidopsis thaliana (wall cress) 26930 Batrachochytrium dendrobatidis (chytrid fungus) 88012 Branchiostoma floridae (lancelet) XP_001902428.1 Brugia malayi (roundworm nematode) ENSBTAP00000034569 Bos taurus (bovine) CN19081 Caenorhabditis brenneri (small nematode) CBP28348 Caenorhabditis briggsae (nematode) CE24542 Caenorhabditis elegans (worm) ENSCAFP00000006917 Canis familiaris (dog) CAGL0A03014g Candida glabrata (haploid yeast) ENSCINP00000003883 Ciona intestinalis (sea squirt) JA16021 Caenorhabditis japonica (nematode) CMM294C Cyanidioschyzon merolae (red alga) cn09101 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000016728 Cavia porcellus (guinea pig) 113649 Chlamidomonas reinhardtii (green alga) RP39233 Caenorhabditis remanei (nematode) ENSCSAVP00000001632 Ciona savignyi (sedentary tunicate) DDB0234047 Dictyostelium discoideum (amoeba) DEHA2D18216g Debaryomyces Hansenii (yeast) 307619 Daphnia pulex (daphnia) ENSDARP00000089699 Danio rerio (zebra fish) ENSECAP00000007578 Equus caballus (horse) ENSGACP00000006923 Gymnopilus aculeatus (mushroom) ENSGALP00000012569 Gallus gallus (chicken) 156059 Hypsipyla robusta (cedar shoot borer) ENSP00000293195 Homo sapiens (human) ISCW020877-PA Ixodes scapularis (deer tick) KLLA0E02531g Kluyveromyces lactis (yeast) 229321 Lottia gigantea (owl limpet) LmjF21.0420 Leishmania major (virus) 16315 Monocosta brevicollis (choanoflagellate) ENSMODP00000008606 Monodelphis domestica (gray opossum) ENSMMUP00000020532 Macaca mulatta (rhesus monkey) ENSMUSP00000021078 Mus musculus (house mouse) 93833 Nematostella vectensis (starlet anemone) ENSOANP00000019899 Ornithorynchus anatinus (platypus) ENSORLP00000025246 Oryzias latipes (japanese killifish) LOC_Os02g17700.1 Oryza sativa (asian rice) 36247 Ostreococcus tauri (green alga) PF11_0407 Plasmodium falciparum (protozoal parasite) PHUM000034-PA Pediculus humanus (human body louse) PP03471 Pristionchus pacificus (nematode) 224842 Physcomitrella patens (moss) ENSPPYP00000009667 Pongo pygmaeus (orangutan) 71984 Phytophthora ramorum (sudden oak death pathogen) 108178 Phytophthora sojae (root rot pathogen) 830556 Populus trichocarpa (black cottonwood) ENSPTRP00000016347 Pan troglodytes (chimpanzee) PVX_092585 Plasmodium vivax (protozoal parasite) PVX_202290 Plasmodium vivax (protozoal parasite) ENSRNOP00000004592 Rattus norvegicus (norway rat) 5055033 Sorghum bicolor (sorghum) YDR376W Saccharomyces cerevisiae (budding yeast) Smp_166580 Schistosoma mansoni (trematode parasite) SPBC3B8.01c Schizosaccharomyces pombe (fission yeast) XP_001192852.1 Strongylocentrotus purpuratus (purple sea urchin) 21502 Trichoplax adhaerens (metazoa) XP_970322.1 Tribolium castaneum (red flour beetle) Tc00.1047053511367.230 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022643 Tetraodon nigroviridis (green spotted pufferfish) 10895 Thalassiosira pseudonana (marine diatom) ENSTRUP00000020417 Takifugu rubripes (pufferfish Takifugu) 3686.m00956 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000014989 Xenopus tropicalis (frog) YALI0B14839g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36203 modMine - Data generated by the modENCODE project. • FBgn0015582 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11855 NV50160 LH18869 ISCW020877 FBgn0230736 FBgn0223612 FBgn0202206 FBgn0197199 FBgn0186923 FBgn0175335 JGI_V11_307619 FBgn0071654 FBgn0154345 FBgn0142377 FBgn0129393 FBgn0114840 FBgn0089454 ACYPI004683 GB17540 AGAP005419 AAEL006733 AAEL005990 PHUM454900 GLEAN_14987
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	AR (Freeman et al., 1997, Freeman and Carlson, 1996) CG12390 (Keleman et al., 2009.8.5, Perkins et al., 2009) dare (Freeman et al., 1999, Kozlova and Thummel, 2000, Telonis-Scott et al., 2009, Xiang et al., 2010, Lorbeck et al., 2010) Dare (Shim et al., 2009, Terashima and Bownes, 2005) W8 (Freeman et al., 1999)
Name Synonym	Adrenodoxin reductase (Freeman et al., 1997, Freeman and Carlson, 1996) ADXRDTASE (Tijet et al., 2001) defective in the avoidance of repellents (Freeman et al., 1997, Lorbeck et al., 2010, Terashima and Bownes, 2005)
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 2 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Lorbeck et al., 2010, Gene 450(1-2): 8--17 The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. [FBrf0209540] Xiang et al., 2010, Dev. Biol. 344(2): 800--808 br regulates the expression of the ecdysone biosynthesis gene npc1. [FBrf0211381] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...