APC1, D-APC, dAPC, adenomatous polyposis coli, dAPC1
8 (northern blot)
2416 (aa); 260 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Apc using the Feature Mapper tool.
The Apc protein colocalizes with shot on microtubules in mature tendon cells of third instar larvae. There is a focus of staining overlapping a compact microtubule array near the muscle-tendon junction. This unique subcellular structure extends to the cuticle attachment site.
Embryonic expression of Apc protein is ubiquitous, but more pronounced in the CNS.
Apc protein is detected in the nervous system of embryos from germ-band retraction on. It localizes to axon fiber tracts and motor neurons. Initially, similar levels are found in longitudinal and commissural tracts. Later, staining is more intense in the longitudinal tracts and is distributed in patches or streaks within specific fibers in the longitudinal tracts.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Apc in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Apc is capable of down-regulating β-catenin in a colon carcinoma cell line and of interacting with the arm protein in vivo. Its expression pattern and preliminary genetic analysis suggest that it may not be an essential component of arm regulation in the wg pathway.