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Gene Dmel\Apc

General Information
Symbol	Dmel\Apc	Species	D. melanogaster
Name	APC-like	Annotation symbol	CG1451
Feature type	protein_coding_gene	FlyBase ID	FBgn0015589
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	APC1, dAPC, D-APC, dAPC1
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	98E5-98E6	Sequence location	3R:24,658,023..24,670,470 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene APC-like is referred to in FlyBase by the symbol Dmel\Apc (CG1451, FBgn0015589). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: beta-catenin binding. There is experimental evidence for 15 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; system development; cellular component organization or biogenesis; localization; regulation of Wnt receptor signaling pathway; cell proliferation; larval chitin-based cuticle development; cellular process; regulation of developmental process; cellular macromolecule localization; regulation of cellular component organization; establishment or maintenance of cytoskeleton polarity; embryonic development via the syncytial blastoderm; instar larval development; regulation of signal transduction. 17 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; organ system; histaminergic neuron; adult; portion of tissue; multi-tissue structure; male organism; somatic cell of testis. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Adenomatous polyposis coli (APC) family; Adenomatous polyposis coli protein, 15 residue repeat; Adenomatous polyposis coli protein, cysteine-rich repeat; Armadillo; Armadillo-like helical; Armadillo-type fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628548_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Apc. Gene sequence location is 3R:24658023..24670470.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98E5-98E6   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98E-98F     (Hayashi, 1996.11.11) 98F-98F   (determined by in situ hybridisation)   (Hayashi et al., 1997) 98D-98E   (determined by in situ hybridisation)   (Ahmed et al., 1996)
Experimentally Determined Recombination Data
Location	3- (Ahmed et al., 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Apc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Apc-RA FBtr0085351  NM_057804   8441   2417 Apc-RB FBtr0336767  NM_001276117   8317   2417
Additional Transcript Data & Comments
Reported size (kB)	8 (northern blot) (Hayashi et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Apc-PA   FBpp0084720   261.3   2417   5.35     NP_477152   AAF56820 Apc-PB   FBpp0307743   261.3   2417   5.35     NP_001263046   AGB96426
Additional Polypeptide Data & Comments
Reported size (kDa)	2416 (aa); 260 (kD predicted) (Hayashi et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Adenomatous polyposis coli protein, cysteine-rich repeat (IPR009223) Adenomatous polyposis coli protein, 15 residue repeat (IPR009240) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Adenomatous polyposis coli (APC) family (IPR026818)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56820   AC006170   AE014297 AGB96426   AI062055   AI062238   AI405568   AI455610   AI515745   AI517709   AI518513   BF489221   BF497123   BG632001   BG632015   BG638753   BP541915   CK131370   CO288974   CO303452   CO303694   CO305636   CO306071   CO324554   CO345168   CZ466690   CZ466691   CZ481855   EC060749   EC065857   EC202326   EC202695   EC203136   EC214744   EC235271   EC242905   EC257557   EV594705   EV594773   GH975227   U77947 AAB41404   Z50582
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VAS9 P91667
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Hayashi et al., 1997) embryonic stage 14 -- 17   presumptive embryonic/larval nervous system   (Hayashi et al., 1997) epidermis   (Hayashi et al., 1997)
Additional Descriptive Data
	Apc transcripts are observed in very early embyros and are not seen again until after germ band retraction. At that time they are concentrated in the CNS where they are restricted to postmitotic cells. Transcripts are also found in the epidermis. (Hayashi et al., 1997)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   motor neuron   (Hayashi et al., 1997) longitudinal connective   (Hayashi et al., 1997) ventral nerve cord commissure   (Hayashi et al., 1997) neuron   • axon (Hayashi et al., 1997) embryonic stage   organism | ubiquitous   (Ahmed et al., 2002) Comment:Expression more prominent in CNS. embryonic stage 13 -- 17   presumptive embryonic/larval nervous system   (Hayashi et al., 1997) third instar larval stage   tendon cell   • microtubule cytoskeleton (Subramanian et al., 2003)
Additional Descriptive Data
	The Apc protein colocalizes with shot on microtubules in mature tendon cells of third instar larvae. There is a focus of staining overlapping a compact microtubule array near the muscle-tendon junction. This unique subcellular structure extends to the cuticle attachment site. (Subramanian et al., 2003) Apc protein is detected in the nervous system of embryos from germ-band retraction on. It localizes to axon fiber tracts and motor neurons. Initially, similar levels are found in longitudinal and commissural tracts. Later, staining is more intense in the longitudinal tracts and is distributed in patches or streaks within specific fibers in the longitudinal tracts. (Hayashi et al., 1997) Embryonic expression of Apc protein is ubiquitous, but more pronounced in the CNS. (Ahmed et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical part of cell inferred from direct assay (Ahmed et al., 1998) axon inferred from direct assay (Akong et al., 2002) cytoplasm inferred from direct assay (Akong et al., 2002, Ahmed et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (763.275) Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain  (916.1) Adult Thoracic-Abdominal Ganglion  (768.9) Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain  (916.1) Adult Thoracic-Abdominal Ganglion  768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    303.8   NA  Eye    174.575   NA  Brain    916.1   763.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    768.9   NA  Crop    191.4   201.6  Midgut    257.2   267.4  Hindgut    190   307.5  Malpighian Tubules    296.1   238.9  Fat Body    200.7   263.2  Salivary Gland    191.5   NA  Heart    148.5   244.45  Trachea    NA   NA  VirginFemale Spermatheca    295.7   NA  InseminatedFemale Spermatheca    269.7   NA  Ovary    483.4   NA  Testis    96.7   NA  Male Accessory Gland    146   219.775  Carcass    132.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    37 central nervous system, pupae P8    43 head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (37) central nervous system, pupae P8  (43) head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    37 central nervous system, pupae P8    43 head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    37 central nervous system, pupae P8    43 head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    37 central nervous system, pupae P8    43 head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (37) central nervous system, pupae P8  (43) head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    37 central nervous system, pupae P8    43 head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    37 central nervous system, pupae P8    43 head, virgin 1-day female    12 head, virgin 4-day female    14 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    13 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    23 ovary, mated 4-day female    22 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP    26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP  26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP    26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP    26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP    26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP  26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP    26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    9 embryo 04-06hr    4 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    20 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    16 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    23 pupae 2d postWPP    26 pupae 3d postWPP    10 pupae 4d postWPP    6 adult male 01day    9 adult male 05day    10 adult male 30day    10 adult female 01day    11 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2    39 embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    41 ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (29) Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2  (39) embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2  (41) ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2    39 embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    41 ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2    39 embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    41 ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2    39 embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    41 ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2  (39) embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2  (41) ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2    39 embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    41 ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    25 embryonic GM2    39 embryonic Kc167    19 embryonic S1    12 embryonic S3    13 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    41 ovary fGS/OSS    23 ovary OSC    20 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015589 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1451-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | adult stage ApcQ8 lethal | recessive | heat sensitive ApcQ8 viable ApcQ8 viable, with Scer\GAL4pros.PMG ApcScer\UAS.cHa Other Phenotypes Allele increased cell death ApcQ8 increased cell death | pupal stage (with ApcQ8) ApcS76 increased cell death | pupal stage (with ApcS76) ApcQ8 Phenotype manifest in Allele eye photoreceptor cell ApcQ8 eye photoreceptor cell | P-stage (with ApcQ8) ApcS76 eye photoreceptor cell | P-stage (with ApcS76) ApcQ8 hub cell Apcunspecified male germline stem cell & centrosome (with Df(3R)3450) ApcQ8 male germline stem cell & spindle (with Df(3R)3450) ApcQ8 male germline stem cell | supernumerary Apcunspecified neuron & retina & pupa ApcQ8 photoreceptor | adult stage ApcQ8 photoreceptor cell ApcQ8 photoreceptor cell R1 ApcQ8 photoreceptor cell R2 ApcQ8 photoreceptor cell R3 ApcQ8 photoreceptor cell R4 ApcQ8 photoreceptor cell R5 ApcQ8 photoreceptor cell R6 ApcQ8 photoreceptor cell R7 ApcQ8 photoreceptor cell R8 ApcQ8
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Apc Class Mutagen Stocks Known lesion Apcc00746 piggyBac transposase 1 -- Apce04097 piggyBac transposase 1 -- ApcMB08754 1 -- ApcMI01007 1 -- ApcQ8 1 Yes ApcS76 0 Yes Apcunspecified 0 -- ApcX1 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Apc Class Mutagen Stocks Known lesion ApcGD1333 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ApcHM05070 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ApcHMS00188 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ApcendsatSAMP.T:Avic\GFP in vitro construct - coding region fusion 0 Yes ApcKK105718 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ApcNIG.1451R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ApcScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes ApcScer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ApcWT.T:Avic\GFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)3450 (Hayashi et al., 1997) Df(3R)BSC789 (Christensen et al., 2009.5.6) Df(3R)Exel6210 (Ryder, 2004.4.26)
Not disrupted in	T(?;3)1S3 (Brumby et al., 2004)
Not duplicated in	Dp(3;1)B152 (Hayashi et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1333} NA P{KK105718} NA P{NIG.1451R} NA P{TRiP.HM05070} NA P{TRiP.HMS00188} NA P{UAS-Apc.H} NA P{UAS-Apc.RFP} NA characterization construct P{Apc.GFP.endsatSAMP} NA P{Apc.GFP.WT} NA P{Apc-EGFP.APC1CT} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}ApcMI01007 NA PBac{PB}Apcc00746 NA PBac{RB}Apce04097 NA insertion of enhancer trap binary system Mi{ET1}ApcMB08754 No
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 19 terms )
Molecular Function
CV term Evidence References
beta-catenin binding inferred from direct assay (Hayashi et al., 1997)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Apc2 (Hayden et al., 2007) brain development inferred from genetic interaction with Apc2 (Akong et al., 2002) cell-cell adhesion inferred from genetic interaction with Apc2 (Hayden et al., 2007) chitin-based larval cuticle pattern formation inferred from genetic interaction with Apc2 (Akong et al., 2002) establishment or maintenance of microtubule cytoskeleton polarity inferred from mutant phenotype (Mattie et al., 2010) head involution inferred from genetic interaction with Apc2 (Akong et al., 2002) imaginal disc pattern formation inferred from genetic interaction with Apc2 (Akong et al., 2002) intracellular protein transport inferred from mutant phenotype (Henthorn et al., 2011) medulla oblongata development inferred from genetic interaction with Apc2 (Hayden et al., 2007) negative regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Ahmed et al., 1998) negative regulation of Wnt receptor signaling pathway inferred from genetic interaction with Apc2 (Hayden et al., 2007) inferred from genetic interaction with arm (Ahmed et al., 1998) neuroblast proliferation inferred from genetic interaction with Apc2 (Akong et al., 2002) oocyte localization involved in germarium-derived egg chamber formation inferred from genetic interaction with Apc2 (Hamada and Bienz, 2002) positive regulation of protein complex assembly inferred from genetic interaction with dsh (Mendoza-Topaz et al., 2011) regulation of Wnt receptor signaling pathway inferred from genetic interaction with Apc2 (Ahmed et al., 2002, Akong et al., 2002)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Ahmed et al., 1998) axon inferred from direct assay (Akong et al., 2002) cytoplasm inferred from direct assay (Akong et al., 2002, Ahmed et al., 1998)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Apc - arm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Apc allele Gene References ApcQ8 Apc2 (Hamada and Bienz, 2002, Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002) arm (Ahmed et al., 1998) pan (Ahmed et al., 1998) sgg (Ahmed et al., 1998) ApcScer\UAS.cHa Apc2 (Ahmed et al., 2002, Akong et al., 2002) unspecified Apc2 (Takacs et al., 2008, Takacs et al., 2008)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69178 DroID - A comprehensive database of gene and protein interactions. • FBgn0015589 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44642 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P91667
Orthologs
OrthoDB Orthologs (53) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RNBTQ Dipteran inclusive ortholog search EOG60K86T Insect inclusive ortholog search EOG6MW71V Arthropod inclusive ortholog search EOG64MW6S Metazoa inclusive ortholog search EOG6G2081
Orthologs in Drosophila Species (EOG6RNBTQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Apc     Drosophila simulans   Dsim\GD18013     Drosophila sechellia   Dsec\GM12280 Y   Drosophila erecta   Dere\GG12051 Y   Drosophila yakuba   Dyak\GE10491 Y   Drosophila ananassae   Dana\GF16423 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13041 Y   Drosophila persimilis   Dper\GL23332 Y   Drosophila willistoni   Dwil\GK17591     Drosophila willistoni   Dwil\GK25742     Drosophila willistoni   Dwil\GK10981 Y   Drosophila willistoni   Dwil\GK10184     Drosophila virilis   Dvir\GJ24175 Y   Drosophila mojavensis   Dmoj\GI12817     Drosophila mojavensis   Dmoj\GI10524 Y   Drosophila grimshawi   Dgri\GH18063 Y   Drosophila grimshawi   Dgri\GH18082
Orthologs in non-Drosophila Dipterans (EOG60K86T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP000048 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018110 Y
Orthologs in non-Dipteran Insects (EOG6MW71V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40348 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009184 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23113 Y Atta cephalotes Leafcutter ant  Acep\ACEP11528 Y Atta cephalotes Leafcutter ant  Acep\ACEP27983 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13780 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10524 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22896 Y Linepithema humile Argentine ant  Lhum\LH20760 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12303 Y Solenopsis invicta Red fire ant  Sinv\SINV13647 Y Solenopsis invicta Red fire ant  Sinv\SINV13645 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007045 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013580 Y Pediculus humanus Human body louse  Phum\PHUM390670 Y Tribolium castaneum Red flour beetle  Tcas\TC004396 Y
Orthologs in non-Insect Arthropods (EOG64MW6S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb Y Ixodes scapularis Deer tick  Isca\ISCW012393 Y
Orthologs in non-Arthropod Metazoa (EOG6G2081)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K04G2.8 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018010gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026745gn Y Danio rerio Zebrafish  Drer\CR678040.1 Y Danio rerio Zebrafish  Drer\apc Y Xenopus tropicalis Western clawed frog  Xtro\apc2 Y Xenopus tropicalis Western clawed frog  Xtro\apc Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000000220 Y Mus musculus House mouse  Mmus\Apc Y Mus musculus House mouse  Mmus\Apc2 Y Rattus norvegicus Norway rat  Rnor\Apc Y Rattus norvegicus Norway rat  Rnor\Apc2 Y Homo sapiens Human  Hsap\ENSG00000258864 Y Homo sapiens Human  Hsap\GPRIN1 Y Homo sapiens Human  Hsap\APC Y Homo sapiens Human  Hsap\APC2 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\ENSG00000258864     Hsap\GPRIN1     Hsap\APC     Hsap\APC2
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM12280 Drosophila erecta Dere\GG12051 Drosophila yakuba Dyak\GE10491 Drosophila ananassae Dana\GF16423 Drosophila pseudoobscura pseudoobscura Dpse\GA13041 Drosophila persimilis Dper\GL23332 Drosophila willistoni Dwil\GK10981 Drosophila virilis Dvir\GJ24175 Drosophila mojavensis Dmoj\GI10524 Drosophila grimshawi Dgri\GH18063
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	26400 w1118; Mi{ET1}ApcMB08754 28582 y1 v1; P{TRiP.HM05070}attP2 34869 y1 sc* v1; P{TRiP.HMS00188}attP2 34138 y1 w*; Mi{MIC}ApcMI01007/TM3, Sb1 Ser1 7211 w*; P{neoFRT}82B sr1 e1 Apc2N175K ApcQ8/TM3, P{ActGFP}JMR2, Ser1
Harvard	- PBac{PB}Apcc00746 - PBac{RB}Apce04097
VDRC	v51468 w1118; P{GD1333}v51468 v51469 w1118; P{GD1333}v51469/TM3
Genomic Clones ( 1 )
	BACR48K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11208 AT25158 GH25606 GH28761 LD38053
Other clones	21400 66329 102758 107166 121222 144597 146166 CK01.88C.H8 Dmel_neb_015071_0579_3077 Dmel_neb_015422_0622_2440 EC257557 EK069764 EK194227 EK241461 EK242532 EK249138 EK250216 EP21515 FGC007A10 GH01103 GH01378 LD35136 LD41405 RP004348260
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015589 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44642
Antibody Information
	polyclonal (Hayashi et al., 1997, Ahmed et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Apc CG1451 (Bayraktaroglu, 2000.4.13)
Additional comments	"S(CycEJP)1S3" is unlikely to correspond to "Apc"; mutations in the two loci complement each other. (Brumby et al., 2004)
Other Comments
	Apc and Apc2 are required in intestinal stem cells in the adult midgut to regulate proliferation. (Lee et al., 2009) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) shot recruits Eb1/Apc and promotes microtubule assembly at the muscle-tendon junction. (Subramanian et al., 2003) Regulation of arm by Apc inhibits neuronal apoptosis during retinal development. (Ahmed et al., 1998) Apc is capable of down-regulating β-catenin in a colon carcinoma cell line and of interacting with the arm protein in vivo. Its expression pattern and preliminary genetic analysis suggest that it may not be an essential component of arm regulation in the wg pathway. (Hayashi et al., 1997) Identification: cDNA expression library with an antibody against Hsap\APC. (Ahmed et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057804 NM_001276117 RefSeq (Proteins) • NP_477152 NP_001263046 DDBJ / EMBL / GenBank • AAB41404 AAF56820 AC006170 AGB96426 AI515745 CZ466690 CZ466691 CZ481855 U77947 Z50582 Entrez Gene - A searchable database of RefSeq genes. • 44642 UniProtKB/TrEMBL • P91667 Q9VAS9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Adenomatous polyposis coli protein, cysteine-rich repeat (IPR009223) Adenomatous polyposis coli protein, 15 residue repeat (IPR009240) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Adenomatous polyposis coli (APC) family (IPR026818)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69178 DroID - A comprehensive database of gene and protein interactions. • FBgn0015589 DRSC - Results from RNAi screens. • FBgn0015589 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015589 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1451-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015589 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205670 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44642 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/apc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44642 modMine - Data generated by the modENCODE project. • FBgn0015589 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P91667
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	APC (Roberts et al., 2012, Kai et al., 2005, Mennella et al., 2005, Tolwinski and Wieschaus, 2004, Seto and Bellen, 2004, Kalderon, 2002, Frydman et al., 2005, Bilder, 2004, Jefferson et al., 2004, Delon and Payre, 2004, Lin, 2003, Gonczy, 2002, Tepass et al., 2001, Seidensticker and Behrens, 2000, Behrens, 2000, Morin, 1999, Bienz, 1999, Bergmann et al., 1998, Shulman et al., 1998, Herskowitz and Stahl, 1998, Bienz, 1998, Cadigan and Nusse, 1997, Cavallo et al., 1997, Gumbinger, 1997, Nusse, 1997, Bassett et al., 1997, Heeg-Truesdell, 2006, Polakis, 2007, Nystul and Spradling, 2006, Clevers, 2006, Tountas and Fortini, 2007, Tolwinski, 2007, Bakal et al., 2007, Morrison and Kimble, 2006, Zhou et al., 2008, Wehrli et al., 2008, Marques, 2005, Vincent et al., 2011, Baranov et al., 2011, Liebl and Featherstone, 2008, Zhou et al., 2011, Rao et al., 2008, Roberts et al., 2011) apc (Yamashita et al., 2004, Mendes et al., 2009, Tolwinski, 2009) Apc (Furlong, 2005, Bakal et al., 2007, Fre et al., 2009, Schmidt et al., 2008, Toku et al., 2011, Christensen et al., 2009.5.6, Mattie et al., 2010, Japanese National Institute of Genetics, 2012.5.21) APC1 (Xi, 2005, McCartney and Peifer, 2003, Roegiers and Jan, 2004, Hayden et al., 2004, Grevengoed and Peifer, 2003, Subramanian et al., 2003, Akong et al., 2003, Akong et al., 2002, Akong et al., 2002, Zimmerman et al., 2006, Hayden et al., 2006, Zimmerman et al., 2007, McCartney et al., 2006, Nystul and Spradling, 2006, He and Axelrod, 2006, Segalen et al., 2007, Hayden et al., 2007, Zimmerman et al., 2008, Zhou et al., 2011, Viquez et al., 2009, Zimmerman et al., 2010, Roberts et al., 2012, Kunttas-Tatli et al., 2012) apc1 (Lin et al., 2004, Tolwinski and Wieschaus, 2004, Yamashita et al., 2004, Lin et al., 2004, Yamashita et al., 2003, Yamashita et al., 2003, Mendes et al., 2009, Tolwinski, 2009, Henthorn et al., 2011) Apc1 (Webb et al., 2005, Nouri et al., 2003, Ahmed et al., 2002, Nouri et al., 2002, Takacs et al., 2008, Benchabane et al., 2011, Benchabane et al., 2011, Takacs et al., 2008, Yamashita et al., 2005, Xin et al., 2011, Cordero et al., 2009, Muñoz-Descalzo et al., 2011, Benchabane et al., 2008, Lee et al., 2009) apc 1 (Tolwinski, 2009) APC-like (Hoopfer et al., 2008) CG1451 (Goldstein and Gunawardena, 2000, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dAPC (Hamada and Bienz, 2002, Bienz, 2002, Akong et al., 2002, Mimori-Kiyosue and Tsukita, 2001, Akong et al., 2001, Roose and Clevers, 1999, Wells, 1999, McCartney et al., 1999, van Es et al., 1999, Rubenstein and Peifer, 1999, Dale, 1998) DAPC (McEwen and Peifer, 2001) D-APC (Ahmed et al., 2001, Hafler et al., 2000, Siegfried and Steitz, 2000, Potter et al., 2000, Bonini and Fortini, 1999, Hayashi, 1996.11.11, Hamada et al., 1999, Hamada et al., 1999, Polakis, 1999, Loureiro, 1999, Russ, 1998, Russ, 1998, Ahmed et al., 1998, Hayashi et al., 1997, Hayashi et al., 1997) dApc (Bienz and Clevers, 2000, van Es et al., 1999, Mieszczanek et al., 2008, Mendoza-Topaz et al., 2011) d-APC (Ahmed et al., 1996) dAPC1 (Humbert et al., 2003, Quijano et al., 2010, Bhandari and Shashidhara, 2001) D-APC1 (Ahmed et al., 1999) Dm APC1 (Konikoff et al., 2010)
Name Synonym	adenomatous polyposis coli (Hayashi et al., 1997, Nystul and Spradling, 2006, Baranov et al., 2011, Rusan et al., 2008) Adenomatous Polyposis Coli (Marques, 2005, Zimmerman et al., 2010) Adenomatous polyposis coli 1 (Xin et al., 2011) adenomatous polyposis coli 1 (Henthorn et al., 2011) Adenomatous Polyposis Coli protein (Zhou et al., 2008) APC-like (Ahmed et al., 1996)
Secondary FlyBase IDs
	FBgn0039604
References ( 181 )
Generate a list of	All references relating to this gene ( 181 )
List References by type	Research paper  ( 61 ) Supplementary material  ( 10 ) Review  ( 53 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 32 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 5 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 15 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Kunttas-Tatli et al., 2012, Genetics 190(3): 1059--1075 Destruction complex function in the wnt signaling pathway of Drosophila requires multiple interactions between adenomatous polyposis coli 2 and armadillo. [FBrf0217816] Roberts et al., 2012, Mol. Biol. Cell 23(11): 2041--2056 Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization. [FBrf0218500] Roberts et al., 2012, PLoS ONE 7(2): e31284 Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development. [FBrf0217546] Vied et al., 2012, Dev. Cell 23(4): 836--848 Regulation of stem cells by intersecting gradients of long-range niche signals. [FBrf0219709] Baranov et al., 2011, RNA Biol. 8(4): 637--647 Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC). [FBrf0216436] Benchabane et al., 2011, EMBO J. 30(8): 1444--1458 Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544] Henthorn et al., 2011, Mol. Biol. Cell 22(21): 4038--4046 A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [FBrf0216511] Mendoza-Topaz et al., 2011, Open Biol. 1(3): 110013 The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. [FBrf0218486] Muñoz-Descalzo et al., 2011, Development 138(8): 1501--1506 Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila. [FBrf0213312] Roberts et al., 2011, Mol. Biol. Cell 22(11): 1845--1863 Deconstructing the sscatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. [FBrf0213765] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vincent et al., 2011, Dev. Cell 21(2): 366--374 Steep differences in wingless signaling trigger myc-independent competitive cell interactions. [FBrf0214665] Xin et al., 2011, Development 138(22): 4955--4967 Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. [FBrf0216486] Zhou et al., 2011, J. Cell Sci. 124(9): 1589--1600 Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. [FBrf0213457] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...