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Gene Dmel\Apc

General Information
Symbol	Dmel\Apc	Species	D. melanogaster
Name	APC-like	Annotation symbol	CG1451
Feature type	protein_coding_gene	FlyBase ID	FBgn0015589
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	APC1, D-APC, dAPC, dAPC1
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	98E5-98E6	Sequence location	3R:24,658,022..24,670,372 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene APC-like is referred to in FlyBase by the symbol Dmel\Apc (CG1451, FBgn0015589). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: beta-catenin binding. There is experimental evidence for 14 unique biological process terms, many of which group under: system development; biological regulation; multicellular organismal development; cellular process; cellular component organization or biogenesis; localization; regulation of Wnt receptor signaling pathway; cell proliferation; larval chitin-based cuticle development; regionalization; embryonic development via the syncytial blastoderm; regulation of signal transduction. 14 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; organ system; histaminergic neuron; adult; multi-tissue structure; male organism; region of integument; somatic cell of testis. It has one annotated transcript and one annotated polypeptide. Protein features are: Adenomatous polyposis coli protein, 15 residue repeat; Adenomatous polyposis coli protein, cysteine-rich repeat; Armadillo; Armadillo-like helical; Armadillo-type fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628548_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Apc. Gene sequence location is 3R:24658022..24670372.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	References Henthorn et al., 2011, Mol. Biol. Cell 22(21): 4038--4046 Sequence features HFA14114 BKN20054 Controlled Vocabulary Terms intracellular protein transport
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98E5-98E6   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98E-98F     (Hayashi, 1996.11.11) 98F-98F   (determined by in situ hybridisation)   (Hayashi et al., 1997) 98D-98E   (determined by in situ hybridisation)   (Ahmed et al., 1996)
Experimentally Determined Recombination Data
Location	3- (Ahmed et al., 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Apc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Apc-RA FBtr0085351  NM_057804   8344   2417
Additional Transcript Data & Comments
Reported size (kB)	8 (northern blot) (Hayashi et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Apc-PA   FBpp0084720   261.3   2417   5.35     NP_477152   AAF56820
Additional Polypeptide Data & Comments
Reported size (kDa)	2416 (aa); 260 (kD predicted) (Hayashi et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Adenomatous polyposis coli protein, cysteine-rich repeat (IPR009223) Adenomatous polyposis coli protein, 15 residue repeat (IPR009240) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56820   AC006170   AI062055   AI062238   AI405568   AI455610   AI515745   AI517709   AI518513   BF489221   BF497123   BG632001   BG632015   BG638753   BP541915   CK131370   CO288974   CO303452   CO303694   CO305636   CO306071   CO324554   CO345168   CZ466690   CZ466691   CZ481855   EC060749   EC065857   EC202326   EC202695   EC203136   EC214744   EC235271   EC242905   EC257557   EV594705   EV594773   GH975227   U77947 AAB41404   Z50582
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	P91667 Q9VAS9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Hayashi et al., 1997) embryonic stage 14 -- 17   presumptive embryonic/larval nervous system   (Hayashi et al., 1997) epidermis   (Hayashi et al., 1997)
Additional Descriptive Data
	Apc transcripts are observed in very early embyros and are not seen again until after germ band retraction. At that time they are concentrated in the CNS where they are restricted to postmitotic cells. Transcripts are also found in the epidermis. (Hayashi et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   motor neuron   (Hayashi et al., 1997) longitudinal connective   (Hayashi et al., 1997) ventral nerve cord commissure   (Hayashi et al., 1997) neuron   • axon (Hayashi et al., 1997) embryonic stage   organism | ubiquitous   (Ahmed et al., 2002) Comment:Expression more prominent in CNS. embryonic stage 13 -- 17   presumptive embryonic/larval nervous system   (Hayashi et al., 1997) third instar larval stage   tendon cell   • microtubule cytoskeleton (Subramanian et al., 2003)
Additional Descriptive Data
	The Apc protein colocalizes with shot on microtubules in mature tendon cells of third instar larvae. There is a focus of staining overlapping a compact microtubule array near the muscle-tendon junction. This unique subcellular structure extends to the cuticle attachment site. (Subramanian et al., 2003) Apc protein is detected in the nervous system of embryos from germ-band retraction on. It localizes to axon fiber tracts and motor neurons. Initially, similar levels are found in longitudinal and commissural tracts. Later, staining is more intense in the longitudinal tracts and is distributed in patches or streaks within specific fibers in the longitudinal tracts. (Hayashi et al., 1997) Embryonic expression of Apc protein is ubiquitous, but more pronounced in the CNS. (Ahmed et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015589    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015589 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015589 expression level Developmental Stage   Expression Level embryo 00-02hr    1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr    1554 embryo 14-16hr    1789 embryo 16-18hr    1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr    1740 pupae 2d postWPP    2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1754) embryo 02-04hr  (726) embryo 04-06hr  (281) embryo 06-08hr  (471) embryo 08-10hr  (987) embryo 10-12hr  (1030) embryo 12-14hr  (1554) embryo 14-16hr  (1789) embryo 16-18hr  (1491) embryo 18-20hr  (1232) embryo 20-22hr  (1119) embryo 22-24hr  (1140) larva L1  (891) larva L2  (503) larva L3 12hr old  (461) larva L3 puffstage 1-2  (305) larva L3 puffstage 3-6  (668) larva L3 puffstage 7-9  (733) white prepupae new  (951) white prepupae 12hr  (1190) white prepupae 24hr  (1740) pupae 2d postWPP  (2028) pupae 3d postWPP  (735) pupae 4d postWPP  (457) adult male 01day  (664) adult male 05day  (792) adult male 30day  (765) adult female 01day  (852) adult female 05day  (1334) adult female 30day  (1329) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1754) embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr  (1554) embryo 14-16hr  (1789) embryo 16-18hr  1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr  (1740) pupae 2d postWPP  (2028) pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr    1554 embryo 14-16hr    1789 embryo 16-18hr    1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr    1740 pupae 2d postWPP    2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr    1554 embryo 14-16hr    1789 embryo 16-18hr    1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr    1740 pupae 2d postWPP    2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015589 expression level Developmental Stage   Expression Level embryo 00-02hr    1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr    1554 embryo 14-16hr    1789 embryo 16-18hr    1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr    1740 pupae 2d postWPP    2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1754) embryo 02-04hr  (726) embryo 04-06hr  (281) embryo 06-08hr  (471) embryo 08-10hr  (987) embryo 10-12hr  (1030) embryo 12-14hr  (1554) embryo 14-16hr  (1789) embryo 16-18hr  (1491) embryo 18-20hr  (1232) embryo 20-22hr  (1119) embryo 22-24hr  (1140) larva L1  (891) larva L2  (503) larva L3 12hr old  (461) larva L3 puffstage 1-2  (305) larva L3 puffstage 3-6  (668) larva L3 puffstage 7-9  (733) white prepupae new  (951) white prepupae 12hr  (1190) white prepupae 24hr  (1740) pupae 2d postWPP  (2028) pupae 3d postWPP  (735) pupae 4d postWPP  (457) adult male 01day  (664) adult male 05day  (792) adult male 30day  (765) adult female 01day  (852) adult female 05day  (1334) adult female 30day  (1329) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr  1554 embryo 14-16hr  1789 embryo 16-18hr  1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr  1740 pupae 2d postWPP  2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr    1554 embryo 14-16hr    1789 embryo 16-18hr    1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr    1740 pupae 2d postWPP    2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1754 embryo 02-04hr    726 embryo 04-06hr    281 embryo 06-08hr    471 embryo 08-10hr    987 embryo 10-12hr    1030 embryo 12-14hr    1554 embryo 14-16hr    1789 embryo 16-18hr    1491 embryo 18-20hr    1232 embryo 20-22hr    1119 embryo 22-24hr    1140 larva L1    891 larva L2    503 larva L3 12hr old    461 larva L3 puffstage 1-2    305 larva L3 puffstage 3-6    668 larva L3 puffstage 7-9    733 white prepupae new    951 white prepupae 12hr    1190 white prepupae 24hr    1740 pupae 2d postWPP    2028 pupae 3d postWPP    735 pupae 4d postWPP    457 adult male 01day    664 adult male 05day    792 adult male 30day    765 adult female 01day    852 adult female 05day    1334 adult female 30day    1329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015589    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015589 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015589 expression level Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (763.275) Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain  (916.1) Adult Thoracic-Abdominal Ganglion  (768.9) Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015589 expression level Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain  (916.1) Adult Thoracic-Abdominal Ganglion  768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    763.275 Larval Midgut    201.6 Larval Hindgut    267.4 Larval Malpighian Tubules    307.5 Larval Fat Body    238.9 Larval Salivary Gland    263.2 Larval Trachea    244.45 Larval Carcass    219.775 Adult Head    303.8 Adult Eye    174.575 Adult Brain    916.1 Adult Thoracic-Abdominal Ganglion    768.9 Adult Crop    191.4 Adult Midgut    257.2 Adult Hindgut    190 Adult Malpighian Tubules    296.1 Adult Fat Body    200.7 Adult Salivary Gland    191.5 Adult Heart    148.5 Adult VirginFemale Spermatheca    295.7 Adult InseminatedFemale Spermatheca    269.7 Adult Ovary    483.4 Adult Testis    96.7 Adult Male Accessory Gland    146 Adult Carcass    132.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    303.8   NA  Eye    174.575   NA  Brain    916.1   763.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    768.9   NA  Crop    191.4   201.6  Midgut    257.2   267.4  Hindgut    190   307.5  Malpighian Tubules    296.1   238.9  Fat Body    200.7   263.2  Salivary Gland    191.5   NA  Heart    148.5   244.45  Trachea    NA   NA  VirginFemale Spermatheca    295.7   NA  InseminatedFemale Spermatheca    269.7   NA  Ovary    483.4   NA  Testis    96.7   NA  Male Accessory Gland    146   219.775  Carcass    132.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015589 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1451-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive | heat sensitive ApcQ8 viable ApcQ8 viable, with Scer\GAL4pros.PMG ApcScer\UAS.cHa Other Phenotypes Allele increased cell death ApcQ8 increased cell death | pupal stage (with ApcQ8) ApcS76 increased cell death | pupal stage (with ApcS76) ApcQ8 Phenotype manifest in Allele eye photoreceptor cell ApcQ8 eye photoreceptor cell | P-stage (with ApcQ8) ApcS76 eye photoreceptor cell | P-stage (with ApcS76) ApcQ8 hub cell Apcunspecified male germline stem cell & centrosome (with Df(3R)3450) ApcQ8 male germline stem cell & spindle (with Df(3R)3450) ApcQ8 male germline stem cell | supernumerary Apcunspecified neuron & retina & pupa ApcQ8 photoreceptor cell ApcQ8 photoreceptor cell R1 ApcQ8 photoreceptor cell R2 ApcQ8 photoreceptor cell R3 ApcQ8 photoreceptor cell R4 ApcQ8 photoreceptor cell R5 ApcQ8 photoreceptor cell R6 ApcQ8 photoreceptor cell R7 ApcQ8 photoreceptor cell R8 ApcQ8
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Apc Class Mutagen Stocks Known lesion Apcc00746 piggyBac transposase 1 -- Apce04097 piggyBac transposase 1 -- ApcMB08754 1 -- ApcMI01007 1 -- ApcQ8 1 Yes ApcS76 0 Yes Apcunspecified 0 -- ApcX1 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Apc Class Mutagen Stocks Known lesion ApcGD1333 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ApcHM05070 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ApcHMS00188 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ApcKK105718 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ApcScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes ApcScer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)3450 (Hayashi et al., 1997) Df(3R)BSC789 (Christensen et al., 2009.5.6) Df(3R)Exel6210 (Ryder, 2004.4.26)
Not disrupted in	T(?;3)1S3 (Brumby et al., 2004)
Not duplicated in	Dp(3;1)B152 (Hayashi et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1333} NA P{KK105718} NA P{TRiP.HM05070} NA P{TRiP.HMS00188} NA P{UAS-Apc.H} NA P{UAS-Apc.RFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}ApcMI01007 NA PBac{PB}Apcc00746 NA PBac{RB}Apce04097 NA insertion of enhancer trap binary system Mi{ET1}ApcMB08754 No
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
beta-catenin binding inferred from direct assay (Hayashi et al., 1997)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Apc2 (Hayden et al., 2007) brain development inferred from genetic interaction with Apc2 (Akong et al., 2002) cell-cell adhesion inferred from genetic interaction with Apc2 (Hayden et al., 2007) chitin-based larval cuticle pattern formation inferred from genetic interaction with Apc2 (Akong et al., 2002) establishment or maintenance of microtubule cytoskeleton polarity inferred from mutant phenotype (Mattie et al., 2010) head involution inferred from genetic interaction with Apc2 (Akong et al., 2002) imaginal disc pattern formation inferred from genetic interaction with Apc2 (Akong et al., 2002) intracellular protein transport inferred from mutant phenotype (Henthorn et al., 2011) medulla oblongata development inferred from genetic interaction with Apc2 (Hayden et al., 2007) negative regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Ahmed et al., 1998) negative regulation of Wnt receptor signaling pathway inferred from genetic interaction with Apc2 (Hayden et al., 2007) inferred from genetic interaction with arm (Ahmed et al., 1998) neuroblast proliferation inferred from genetic interaction with Apc2 (Akong et al., 2002) oocyte localization involved in germarium-derived egg chamber formation inferred from genetic interaction with Apc2 (Hamada and Bienz, 2002) regulation of Wnt receptor signaling pathway inferred from genetic interaction with Apc2 (Ahmed et al., 2002, Akong et al., 2002)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Ahmed et al., 1998) axon inferred from direct assay (Akong et al., 2002) cytoplasm inferred from direct assay (Akong et al., 2002, Ahmed et al., 1998)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Apc allele Gene References ApcQ8 Apc2 (Hamada and Bienz, 2002, Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002) arm (Ahmed et al., 1998) pan (Ahmed et al., 1998) sgg (Ahmed et al., 1998) ApcScer\UAS.cHa Apc2 (Ahmed et al., 2002, Akong et al., 2002) unspecified Apc2 (Takacs et al., 2008, Takacs et al., 2008)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69178 DroID - A comprehensive database of gene and protein interactions. • FBgn0015589 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44642
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16423 Dere\GG12051 Dgri\GH18063 Dmoj\GI10524 Dper\GL23332 Dpse\GA13041 Dsec\GM12280 Dvir\GJ24175 Dwil\GK10981 Dyak\GE10491
Curated drosophilid orthologs	Dpse\GA13041
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_624558.2 Apis mellifera (honey bee) XP_001942832.1 Acyrthosiphon pisum (pea aphid) BGIBMGA013580-PA Bombyx mori (silk worm) ENSBTAP00000025099 Bos taurus (bovine) CN06651 Caenorhabditis brenneri (small nematode) CN20978 Caenorhabditis brenneri (small nematode) CBP02016 Caenorhabditis briggsae (nematode) ENSCAFP00000010888 Canis familiaris (dog) CPIJ018864 Culex pipens (mosquito) ENSCPOP00000001434 Cavia porcellus (guinea pig) ENSECAP00000007276 Equus caballus (horse) ENSGACP00000020460 Gymnopilus aculeatus (mushroom) ENSGALP00000000295 Gallus gallus (chicken) 191982 Hypsipyla robusta (cedar shoot borer) ENSP00000257430 Homo sapiens (human) ENSMODP00000016609 Monodelphis domestica (gray opossum) ENSMMUP00000000446 Macaca mulatta (rhesus monkey) ENSMUSP00000078337 Mus musculus (house mouse) XP_001602839.1 Nasonia vitripennis (wasp) ENSOANP00000001316 Ornithorynchus anatinus (platypus) ENSORLP00000020145 Oryzias latipes (japanese killifish) PHUM009146-PA Pediculus humanus (human body louse) ENSPPYP00000017538 Pongo pygmaeus (orangutan) ENSPTRP00000029327 Pan troglodytes (chimpanzee) ENSRNOP00000027691 Rattus norvegicus (norway rat) Smp_139190 Schistosoma mansoni (trematode parasite) XP_001192659.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000016224 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026622 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046491 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12303 NV14300 LH20760 ISCW012393 FBgn0228351 FBgn0212992 FBgn0211259 FBgn0189558 FBgn0167217 JGI_V11_44029 FBgn0073079 FBgn0160922 FBgn0133288 FBgn0125531 FBgn0104343 FBgn0093444 CPIJ018110 BGIBMGA013580 ACYPI007045 GB17140 AGAP000048 PHUM390670 GLEAN_04396
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	26400 w1118; Mi{ET1}ApcMB08754 28582 y1 v1; P{TRiP.HM05070}attP2 34869 y1 sc* v1; P{TRiP.HMS00188}attP2 34138 y1 w*; Mi{MIC}ApcMI01007/TM3, Sb1 Ser1 7211 w*; P{neoFRT}82B sr1 e1 Apc2N175K ApcQ8/TM3, P{ActGFP}JMR2, Ser1
Harvard	- PBac{PB}Apcc00746 - PBac{RB}Apce04097
VDRC	v51468 w1118; P{GD1333}v51468 v51469 w1118; P{GD1333}v51469/TM3
Genomic Clones ( 1 )
	BACR48K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11208 AT25158 GH25606 GH28761 LD38053
Other clones	21400 66329 102758 107166 121222 144597 146166 CK01.88C.H8 Dmel_neb_015071_0579_3077 Dmel_neb_015422_0622_2440 EC257557 EK069764 EK194227 EK241461 EK242532 EK249138 EK250216 EP21515 FGC007A10 GH01103 GH01378 LD35136 LD41405 RP004348260
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015589 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44642
Antibody Information
	polyclonal (Hayashi et al., 1997, Ahmed et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Apc CG1451 (Bayraktaroglu, 2000.4.13)
Additional comments	"S(CycEJP)1S3" is unlikely to correspond to "Apc"; mutations in the two loci complement each other. (Brumby et al., 2004)
Other Comments
	Apc and Apc2 are required in intestinal stem cells in the adult midgut to regulate proliferation. (Lee et al., 2009) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) shot recruits Eb1/Apc and promotes microtubule assembly at the muscle-tendon junction. (Subramanian et al., 2003) Regulation of arm by Apc inhibits neuronal apoptosis during retinal development. (Ahmed et al., 1998) Apc is capable of down-regulating β-catenin in a colon carcinoma cell line and of interacting with the arm protein in vivo. Its expression pattern and preliminary genetic analysis suggest that it may not be an essential component of arm regulation in the wg pathway. (Hayashi et al., 1997) Identification: cDNA expression library with an antibody against Hsap\APC. (Ahmed et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057804 RefSeq (Proteins) • NP_477152 DDBJ / EMBL / GenBank • AAB41404 AAF56820 AC006170 AI515745 CZ466690 CZ466691 CZ481855 U77947 Z50582 Entrez Gene - A searchable database of RefSeq genes. • 44642 UniProtKB/TrEMBL • P91667 Q9VAS9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Adenomatous polyposis coli protein, cysteine-rich repeat (IPR009223) Adenomatous polyposis coli protein, 15 residue repeat (IPR009240) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69178 DroID - A comprehensive database of gene and protein interactions. • FBgn0015589 DRSC - Results from RNAi screens. • FBgn0015589 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015589 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1451-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015589 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205670 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44642 InParanoid A subset of ortholog calls from InParanoid. • XP_624558.2 Apis mellifera (honey bee) XP_001942832.1 Acyrthosiphon pisum (pea aphid) BGIBMGA013580-PA Bombyx mori (silk worm) ENSBTAP00000025099 Bos taurus (bovine) CN06651 Caenorhabditis brenneri (small nematode) CN20978 Caenorhabditis brenneri (small nematode) CBP02016 Caenorhabditis briggsae (nematode) ENSCAFP00000010888 Canis familiaris (dog) CPIJ018864 Culex pipens (mosquito) ENSCPOP00000001434 Cavia porcellus (guinea pig) ENSECAP00000007276 Equus caballus (horse) ENSGACP00000020460 Gymnopilus aculeatus (mushroom) ENSGALP00000000295 Gallus gallus (chicken) 191982 Hypsipyla robusta (cedar shoot borer) ENSP00000257430 Homo sapiens (human) ENSMODP00000016609 Monodelphis domestica (gray opossum) ENSMMUP00000000446 Macaca mulatta (rhesus monkey) ENSMUSP00000078337 Mus musculus (house mouse) XP_001602839.1 Nasonia vitripennis (wasp) ENSOANP00000001316 Ornithorynchus anatinus (platypus) ENSORLP00000020145 Oryzias latipes (japanese killifish) PHUM009146-PA Pediculus humanus (human body louse) ENSPPYP00000017538 Pongo pygmaeus (orangutan) ENSPTRP00000029327 Pan troglodytes (chimpanzee) ENSRNOP00000027691 Rattus norvegicus (norway rat) Smp_139190 Schistosoma mansoni (trematode parasite) XP_001192659.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000016224 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026622 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046491 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/apc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44642 modMine - Data generated by the modENCODE project. • FBgn0015589 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12303 NV14300 LH20760 ISCW012393 FBgn0228351 FBgn0212992 FBgn0211259 FBgn0189558 FBgn0167217 JGI_V11_44029 FBgn0073079 FBgn0160922 FBgn0133288 FBgn0125531 FBgn0104343 FBgn0093444 CPIJ018110 BGIBMGA013580 ACYPI007045 GB17140 AGAP000048 PHUM390670 GLEAN_04396
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	APC (Kai et al., 2005, Mennella et al., 2005, Tolwinski and Wieschaus, 2004, Seto and Bellen, 2004, Kalderon, 2002, Frydman et al., 2005, Bilder, 2004, Jefferson et al., 2004, Delon and Payre, 2004, Lin, 2003, Gonczy, 2002, Tepass et al., 2001, Seidensticker and Behrens, 2000, Behrens, 2000, Morin, 1999, Bienz, 1999, Bergmann et al., 1998, Shulman et al., 1998, Herskowitz and Stahl, 1998, Bienz, 1998, Cadigan and Nusse, 1997, Cavallo et al., 1997, Gumbinger, 1997, Nusse, 1997, Bassett et al., 1997, Heeg-Truesdell, 2006, Polakis, 2007, Nystul and Spradling, 2006, Clevers, 2006, Tountas and Fortini, 2007, Tolwinski, 2007, Bakal et al., 2007, Morrison and Kimble, 2006, Zhou et al., 2008, Wehrli et al., 2008, Marques, 2005, Berger et al., 2005, Rao et al., 2008) apc (Yamashita et al., 2004, Mendes et al., 2009, Tolwinski, 2009) Apc (Furlong, 2005, Bakal et al., 2007, Christensen et al., 2009.5.6, Mattie et al., 2010) APC1 (Xi, 2005, McCartney and Peifer, 2003, Roegiers and Jan, 2004, Hayden et al., 2004, Grevengoed and Peifer, 2003, Subramanian et al., 2003, Akong et al., 2003, Akong et al., 2002, Akong et al., 2002, Zimmerman et al., 2006, Hayden et al., 2006, Zimmerman et al., 2007, McCartney et al., 2006, Nystul and Spradling, 2006, He and Axelrod, 2006, Segalen et al., 2007, Hayden et al., 2007, Zimmerman et al., 2008, Viquez et al., 2009, Zimmerman et al., 2010) apc1 (Lin et al., 2004, Tolwinski and Wieschaus, 2004, Yamashita et al., 2004, Lin et al., 2004, Yamashita et al., 2003, Yamashita et al., 2003, Mendes et al., 2009, Tolwinski, 2009, Henthorn et al., 2011) Apc1 (Webb et al., 2005, Nouri et al., 2003, Ahmed et al., 2002, Nouri et al., 2002, Takacs et al., 2008, Benchabane et al., 2011, Benchabane et al., 2011, Takacs et al., 2008, Yamashita et al., 2005, Benchabane et al., 2008, Lee et al., 2009) apc 1 (Tolwinski, 2009) APC-like (Hoopfer et al., 2008) CG1451 (Goldstein and Gunawardena, 2000, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dAPC (Hamada and Bienz, 2002, Bienz, 2002, Akong et al., 2002, Mimori-Kiyosue and Tsukita, 2001, Akong et al., 2001, Roose and Clevers, 1999, Wells, 1999, McCartney et al., 1999, van Es et al., 1999, Rubenstein and Peifer, 1999, Dale, 1998) DAPC (McEwen and Peifer, 2001) D-APC (Ahmed et al., 2001, Hafler et al., 2000, Siegfried and Steitz, 2000, Potter et al., 2000, Bonini and Fortini, 1999, Hayashi, 1996.11.11, Hamada et al., 1999, Hamada et al., 1999, Polakis, 1999, Loureiro, 1999, Russ, 1998, Russ, 1998, Ahmed et al., 1998, Hayashi et al., 1997, Hayashi et al., 1997) dApc (Bienz and Clevers, 2000, van Es et al., 1999, Mieszczanek et al., 2008) d-APC (Ahmed et al., 1996) dAPC1 (Humbert et al., 2003, Quijano et al., 2010, Bhandari and Shashidhara, 2001) D-APC1 (Ahmed et al., 1999) Dm APC1 (Konikoff et al., 2010)
Name Synonym	adenomatous polyposis coli (Hayashi et al., 1997, Nystul and Spradling, 2006, Rusan et al., 2008) Adenomatous Polyposis Coli (Marques, 2005, Zimmerman et al., 2010) adenomatous polyposis coli 1 (Henthorn et al., 2011) Adenomatous Polyposis Coli protein (Zhou et al., 2008) APC-like (Ahmed et al., 1996)
Secondary FlyBase IDs
	FBgn0039604
References ( 162 )
Generate a list of	All references relating to this gene ( 162 )
List References by type	Research paper  ( 45 ) Supplementary material  ( 9 ) Review  ( 53 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 32 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 4 ) Meeting report  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Benchabane et al., 2011, EMBO J. 30(8): 1444--1458 Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544] Henthorn et al., 2011, Mol. Biol. Cell 22(21): 4038--4046 A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [FBrf0216511] Konikoff et al., 2010, J. Mol. Evol. 70(4): 303--312 Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways. [FBrf0210842] Mattie et al., 2010, Curr. Biol. 20(24): 2169--2177 Directed Microtubule Growth, +TIPs, and Kinesin-2 Are Required for Uniform Microtubule Polarity in Dendrites. [FBrf0212550] Quijano et al., 2010, PLoS ONE 5(7): e11619 The Sno Oncogene Antagonizes Wingless Signaling during Wing Development in Drosophila. [FBrf0211340] Zimmerman et al., 2010, Dev. Biol. 340(1): 54--66 Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. [FBrf0210185] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...