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Gene Dmel\Ast

General Information
Symbol	Dmel\Ast	Species	D. melanogaster
Name	Allatostatin	Annotation symbol	CG13633
Feature type	protein_coding_gene	FlyBase ID	FBgn0015591
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	AstA-1, Drm-AST-4, Drm-AST-3, Drm-AST-2, AST-1, DAP, AST-A, AstA
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96A20-96A20	Sequence location	3R:20,586,252..20,590,780 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Allatostatin is referred to in FlyBase by the symbol Dmel\Ast (CG13633, FBgn0015591). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: hormone activity. It is reported to be involved in the biological process: neuropeptide signaling pathway. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Allatostatin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval/adult midgut, larval/adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1632752_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ast. Gene sequence location is 3R:20586252..20590780.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Insertions Mi{MIC}Ast[MI03999] References Bellen, 2011.10.10, MISet953.xml Alleles Ast[MI03999]
FB2012_01	References Carlsson et al., 2010, J. Comp. Neurol. 518(16): 3359--3380 Sequence features HFA14634 BKN31259
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96A20-96A20   Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96A-96B     (Lenz, 2000.5.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ast for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ast-RA FBtr0084744  NM_079765   1446   151
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ast-PA   FBpp0084119   16.9   151   9.51     NP_524489   AAF56331
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Allatostatin (IPR010276)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56331   AF263923 AAF97792   AY071110 AAL48732   BI173601   CO186985   CO187001   CO289597   CO290230   CO328903   EC056800   EC072292   EC081662   EC194917   EC219191   EC240801   GH740491   GH742682   GH743625   GH765395   GH767137   GH767143   GH769339   GH779233
UniProtKB/Swiss-Prot	Q9VC44
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015591    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015591 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015591 expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr  (224) embryo 16-18hr  (465) embryo 18-20hr  (902) embryo 20-22hr  (1154) embryo 22-24hr  (1262) larva L1  (1117) larva L2  (611) larva L3 12hr old  (305) larva L3 puffstage 1-2  (378) larva L3 puffstage 3-6  (405) larva L3 puffstage 7-9  (388) white prepupae new  (272) white prepupae 12hr  (156) white prepupae 24hr  (166) pupae 2d postWPP  (334) pupae 3d postWPP  (500) pupae 4d postWPP  (375) adult male 01day  (499) adult male 05day  (696) adult male 30day  (694) adult female 01day  (277) adult female 05day  (138) adult female 30day  (167) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015591 expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr  (224) embryo 16-18hr  (465) embryo 18-20hr  (902) embryo 20-22hr  (1154) embryo 22-24hr  (1262) larva L1  (1117) larva L2  (611) larva L3 12hr old  (305) larva L3 puffstage 1-2  (378) larva L3 puffstage 3-6  (405) larva L3 puffstage 7-9  (388) white prepupae new  (272) white prepupae 12hr  (156) white prepupae 24hr  (166) pupae 2d postWPP  (334) pupae 3d postWPP  (500) pupae 4d postWPP  (375) adult male 01day  (499) adult male 05day  (696) adult male 30day  (694) adult female 01day  (277) adult female 05day  138 adult female 30day  (167) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    26 embryo 04-06hr    13 embryo 06-08hr    9 embryo 08-10hr    14 embryo 10-12hr    13 embryo 12-14hr    36 embryo 14-16hr    224 embryo 16-18hr    465 embryo 18-20hr    902 embryo 20-22hr    1154 embryo 22-24hr    1262 larva L1    1117 larva L2    611 larva L3 12hr old    305 larva L3 puffstage 1-2    378 larva L3 puffstage 3-6    405 larva L3 puffstage 7-9    388 white prepupae new    272 white prepupae 12hr    156 white prepupae 24hr    166 pupae 2d postWPP    334 pupae 3d postWPP    500 pupae 4d postWPP    375 adult male 01day    499 adult male 05day    696 adult male 30day    694 adult female 01day    277 adult female 05day    138 adult female 30day    167 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015591    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015591 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval/adult midgut, larval/adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015591 expression level Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain    740.8 Adult Thoracic-Abdominal Ganglion    1454.6 Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain  (740.8) Adult Thoracic-Abdominal Ganglion  (1454.6) Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain    740.8 Adult Thoracic-Abdominal Ganglion  (1454.6) Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain    740.8 Adult Thoracic-Abdominal Ganglion    1454.6 Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015591 expression level Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain    740.8 Adult Thoracic-Abdominal Ganglion    1454.6 Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain  740.8 Adult Thoracic-Abdominal Ganglion  (1454.6) Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain    740.8 Adult Thoracic-Abdominal Ganglion  1454.6 Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    254.55 Larval Midgut    200.4 Larval Hindgut    157 Larval Malpighian Tubules no informative data Larval Fat Body    8.9 Larval Salivary Gland    13 Larval Trachea    6.075 Larval Carcass    13.375 Adult Head    173 Adult Eye    19.45 Adult Brain    740.8 Adult Thoracic-Abdominal Ganglion    1454.6 Adult Crop    14 Adult Midgut    195.2 Adult Hindgut    221.9 Adult Malpighian Tubules no informative data Adult Fat Body    27.7 Adult Salivary Gland no informative data Adult Heart    7.175 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    22.4 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland no informative data Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    173   NA  Eye    19.45   NA  Brain    740.8   254.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1454.6   NA  Crop    14   200.4  Midgut    195.2   157  Hindgut    221.9   no informative data  Malpighian Tubules    no informative data   8.9  Fat Body    27.7   13  Salivary Gland    no informative data   NA  Heart    7.175   6.075  Trachea    NA   NA  VirginFemale Spermatheca    23.9   NA  InseminatedFemale Spermatheca    22.4   NA  Ovary    2.1   NA  Testis    6.6   NA  Male Accessory Gland    no informative data   13.375  Carcass    47.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015591 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13633-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ast Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 AstGD6203 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Ast Class Mutagen Stocks Known lesion AstMB10261 1 -- AstMI03999 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ast Class Mutagen Stocks Known lesion AstGD6203 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AstJF01905 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AstKK111259 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6203} NA P{KK111259} NA P{TRiP.JF01905} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}AstMB10261 No miscellaneous insertions Mi{MIC}AstMI03999 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
hormone activity inferred from sequence or structural similarity with UniProtKB:P42559 (FlyBase, 1992-) non-traceable author statement (Lenz, 2000.5.5, Hewes and Taghert, 2001) non-traceable author statement (assigned by UniProtKB) (Lenz et al., 2000) traceable author statement (assigned by UniProtKB) (Baggerman et al., 2002) neuropeptide hormone activity inferred from electronic annotation with InterPro:IPR010276 (FlyBase Curators et al., 2004-) non-traceable author statement (vanden Broeck, 2001)
Biological Process
CV term Evidence References
neuropeptide signaling pathway non-traceable author statement (vanden Broeck, 2001) non-traceable author statement (assigned by UniProtKB) (Lenz et al., 2000) traceable author statement (assigned by UniProtKB) (Baggerman et al., 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ast allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0015591
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23184 Dere\GG12326 Dgri\GH19129 Dmoj\GI23586 Dper\GL13866 Dpse\GA12425 Dsec\GM23467 Dsim\GD18275 Dvir\GJ23562 Dwil\GK13247 Dyak\GE10779
Curated drosophilid orthologs	Dmad\Ast (Munte, 2004.9.23) Dpse\GA12425   Dsub\Ast (Munte, 2004.9.23)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL015251-PA Aedes aegypti (mosquito) AGAP003712-PA Anopheles gambiae (mosquito) XP_001120780.1 Apis mellifera (honey bee) BGIBMGA014377-PA Bombyx mori (silk worm) CPIJ008017 Culex pipens (mosquito) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21997 FBgn0228621 FBgn0215256 FBgn0210659 FBgn0189808 FBgn0178334 JGI_V11_312277 FBgn0072471 FBgn0151471 FBgn0146312 FBgn0126596 FBgn0104616 FBgn0100178 CPIJ008017 BGIBMGA014377 ACYPI24660 AST1 AAEL015251 PB20397 PHUM231810
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	29107 w1118; Mi{ET1}AstMB10261 25866 y1 v1; P{TRiP.JF01905}attP2 36943 y1 w*; Mi{MIC}AstMI03999
VDRC	v103215 P{KK111259}VIE-260B v14397 w1118; P{GD6203}v14397 v14398 w1118; P{GD6203}v14398
Genomic Clones ( 1 )
	BACR33F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE16553
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	28622 CK01.26B.C10 CK01.26C.B10 CK01.91B.H7 CK01.94B.C5 CK01.115D.E4 EK025132 EK025229 EK071432 EK073411 EK291628 RP001017320 RP001020525 RP001021056 RP001025708 RP001026054 RP001030597 RP001035326 RP001037257
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015591 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42947
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ast BcDNA:RE16553 (FlyBase, 1996-) Source for merge of: Ast CG13633 (FlyBase, 1996-)
Additional comments	Source for merge of Ast CG13633 was sequence comparison (date:000815). (FlyBase, 1996-) Source for merge of Ast BcDNA:RE16553 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
	The putative Ast gene product was identified and its expression pattern studied using cross-reactivity with a monoclonal antibody raised against Diploptera punctata allatostatin I. (Yoon and Stay, 1995) The putative Ast gene product was identified and its expression pattern studied using cross-reactivity with an antibody raised against the M.sexta neuropeptide hormone allatostatin. (Zitnan et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079765 RefSeq (Proteins) • NP_524489 DDBJ / EMBL / GenBank • AAF56331 AAF97792 AAL48732 AF263923 AY071110 BI173601 Entrez Gene - A searchable database of RefSeq genes. • 42947 UniProtKB/Swiss-Prot • Q9VC44
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Allatostatin (IPR010276)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0015591 DRSC - Results from RNAi screens. • FBgn0015591 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015591 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13633-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015591 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42947 InParanoid A subset of ortholog calls from InParanoid. • AAEL015251-PA Aedes aegypti (mosquito) AGAP003712-PA Anopheles gambiae (mosquito) XP_001120780.1 Apis mellifera (honey bee) BGIBMGA014377-PA Bombyx mori (silk worm) CPIJ008017 Culex pipens (mosquito) modMine - Data generated by the modENCODE project. • FBgn0015591 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21997 FBgn0228621 FBgn0215256 FBgn0210659 FBgn0189808 FBgn0178334 JGI_V11_312277 FBgn0072471 FBgn0151471 FBgn0146312 FBgn0126596 FBgn0104616 FBgn0100178 CPIJ008017 BGIBMGA014377 ACYPI24660 AST1 AAEL015251 PB20397 PHUM231810
Synonyms & Secondary IDs ( 36 )
Reported As
Symbol Synonym	ASA (Veenstra et al., 2008) Ast (Wegener and Gorbashov, 2008, Kahsai and Winther, 2011) AST (Peixoto et al., 2000, Burtenshaw et al., 2008) ast (Santos et al., 2007) AST-1 (Hewes and Taghert, 2001, Carlsson et al., 2010) AST-3 (Carlsson et al., 2010) AST-4 (Carlsson et al., 2010) AST-A (Santos et al., 2007) Ast-A (Park et al., 2008) AstA (Johnson et al., 2005, Veenstra, 2009) AstA-1 (Johnson et al., 2004, Johnson et al., 2003, Birse et al., 2006) BcDNA:RE16553   CG13633 (Vanden Broeck et al., 2001, Hewes and Taghert, 2001, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Wegener and Gorbashov, 2008) DAP (Lenz, 2000.5.5, Lenz et al., 2000) DAP-A (Lenz et al., 2001) Drm-AST-1 (vanden Broeck, 2001) Drm-AST-2 (Baggerman et al., 2002, vanden Broeck, 2001) Drm-AST-3 (Baggerman et al., 2002, vanden Broeck, 2001) Drm-AST-4 (Baggerman et al., 2002, vanden Broeck, 2001) Drm-AST-A (vanden Broeck, 2001) DST-1A (Larsen et al., 2001) DST-2A (Larsen et al., 2001) DST-3A (Larsen et al., 2001) DST-4A (Larsen et al., 2001)
Name Synonym	Allatostatin (Martínez-Pérez et al., 2009) allatostatin (Peixoto et al., 2000, Santos et al., 2007) allatostatin A (Park et al., 2008, Veenstra, 2009) Allatostatin A (Johnson et al., 2005, Veenstra et al., 2008) allatostatin A-1 (Birse et al., 2006) allatostatin-A4 (Jorgensen et al., 2006) allatostatin-A-like (Vanden Broeck, 2001) drostatin-A1 (Lenz et al., 2001) Drostatin-A2 (Cazzamali et al., 2003) drostatin-A2 (Lenz et al., 2001) drostatin-A3 (Lenz et al., 2001) drostatin-A4 (Egerod et al., 2003, Egerod et al., 2003, Iversen et al., 2002, Iversen et al., 2002, Cazzamali and Grimmelikhuijzen, 2002, Rosenkilde et al., 2003, Lenz et al., 2001)
Secondary FlyBase IDs
	FBgn0012040 FBgn0039220 FBgn0047160
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 2 ) Review  ( 6 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Kahsai and Winther, 2011, J. Comp. Neurol. 519(2): 290--315 Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. [FBrf0212649] Carlsson et al., 2010, J. Comp. Neurol. 518(16): 3359--3380 Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. [FBrf0211156] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...