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Gene Dmel\BEAF-32

General Information
Symbol	Dmel\BEAF-32	Species	D. melanogaster
Name	Boundary element-associated factor of 32kD	Annotation symbol	CG10159
Feature type	protein_coding_gene	FlyBase ID	FBgn0015602
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	BEAF, BEAF32, BEAF-32A, BEAF-32B, BEAF32B, BEAF32A
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	51C2-51C2	Sequence location	2R:10,657,939..10,660,135 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Boundary element-associated factor of 32kD is referred to in FlyBase by the symbol Dmel\BEAF-32 (CG10159, FBgn0015602). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; DNA binding; chromatin insulator sequence binding. There is experimental evidence that it is involved in the biological process: chromatin organization; histone H3-K9 methylation; regulation of transcription from RNA polymerase II promoter; oogenesis. 17 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye disc; eye; interommatidial bristle; egg chamber; ommatidium. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: BESS motif; Zinc finger, BED-type predicted. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624484_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of BEAF-32. Gene sequence location is 2R:10657939..10660135.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 Wallace et al., 2010, Chromosoma 119(2): 177--194 Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Guertin and Lis, 2010, PLoS Genet. 6(9): Sequence features BKN24639 HFA05927
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51C2-51C2   Limits computationally determined from genome sequence between P{lacW}Rpn6k00103 and P{PZ}chn02064
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51D1-51D1     (Hart, 1996.11.15) 51D1-51D1     (Hart, 1995.3.30) 51D1-51D1   (determined by in situ hybridisation)   (Zhao et al., 1995)
Experimentally Determined Recombination Data
Location	2- (Zhao et al., 1995, Hart, 1995.3.30)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\BEAF-32 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) BEAF-32-RA FBtr0087441  NM_079023   1227   283 BEAF-32-RB FBtr0087442  NM_166069   1173   282 BEAF-32-RC FBtr0305588     1536   282
Additional Transcript Data & Comments
Reported size (kB)	1.205 (longest cDNA) (Hart et al., 1997) 1.3 (longest cDNA) (Zhao et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein BEAF-32-PA   FBpp0086571   31.7   283   6.51     NP_523747   AAF58205 BEAF-32-PB   FBpp0086572   31.8   282   6.52     NP_725418   AAG22264 BEAF-32-PC   FBpp0294039   31.8   282   6.52
Additional Polypeptide Data & Comments
Reported size (kDa)	283 (aa); 40, 38 (kD observed); 32 (kD predicted) (Zhao et al., 1995) 282 (aa); 32 (kD predicted) (Hart et al., 1997)
Comments	Two BEAF-32 proteins differ in their amino-terminal sequences presumably as a result of alternative splicing at the 5' end of the gene. Heterocomplexes were found which contain both forms of BEAF-32 protein. The BEAF-32 proteins were shown to have C-terminal protein interaction domains and N-terminal DNA-binding domains. (Hart et al., 1997)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, BED-type predicted (IPR003656) BESS motif (IPR004210)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58205   AE013599 AAG22264   AI134563   AI512475   AI519877   AI520154   AI944686   AW943717   AY058711 AAL13940   BH809555   BH809556   BI162870   BI163268   BI163546   BI212876   BI213338   BI214764   BI230539   BI367511   BT100127   CA807241   CO176803   CO185971   CO266324   CO267773   CO279873   CO287700   CO288728   CO306012   CO311740   CO319326   CO320409   CO331895   CO332723   CZ478603   EC067845   EC070676   EC084689   EC216554   EC219526   EC227265   EC227584   EC234258   EV576828   EV580312   EV585147   FE862624   FE862632   FE862657   FE862679   FE863165   FE863231   FE863260   GH744977   GH745965   GH747100   GH761840   GH762285   GH766743   GH766942   GH767015   GH768071   GH910837   X86007 CAA59994   Y09475 CAA70621
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q94513 Q7JN06
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 3 -- 13   organism | ubiquitous   • nucleus (Hart et al., 1999) embryonic stage 5 -- 13   cell   • nucleus (Hart et al., 1999)   cultured cell-line   • condensed chromosome (Hart et al., 1999) Comment:D1 cells
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term	nucleus (Zhao et al., 1995)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015602    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015602 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015602 expression level Developmental Stage   Expression Level embryo 00-02hr    7559 embryo 02-04hr    8257 embryo 04-06hr    7449 embryo 06-08hr    7326 embryo 08-10hr    6481 embryo 10-12hr    5438 embryo 12-14hr    3495 embryo 14-16hr    3568 embryo 16-18hr    2799 embryo 18-20hr    1771 embryo 20-22hr    3443 embryo 22-24hr    2838 larva L1    1813 larva L2    1408 larva L3 12hr old    986 larva L3 puffstage 1-2    1463 larva L3 puffstage 3-6    2072 larva L3 puffstage 7-9    2624 white prepupae new    2470 white prepupae 12hr    2657 white prepupae 24hr    2657 pupae 2d postWPP    1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day    2327 adult female 05day    3230 adult female 30day    3488 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7559) embryo 02-04hr  (8257) embryo 04-06hr  (7449) embryo 06-08hr  (7326) embryo 08-10hr  (6481) embryo 10-12hr  (5438) embryo 12-14hr  (3495) embryo 14-16hr  (3568) embryo 16-18hr  (2799) embryo 18-20hr  (1771) embryo 20-22hr  (3443) embryo 22-24hr  (2838) larva L1  (1813) larva L2  (1408) larva L3 12hr old  (986) larva L3 puffstage 1-2  (1463) larva L3 puffstage 3-6  (2072) larva L3 puffstage 7-9  (2624) white prepupae new  (2470) white prepupae 12hr  (2657) white prepupae 24hr  (2657) pupae 2d postWPP  (1539) pupae 3d postWPP  (913) pupae 4d postWPP  (1004) adult male 01day  (841) adult male 05day  (958) adult male 30day  (1082) adult female 01day  (2327) adult female 05day  (3230) adult female 30day  (3488) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7559) embryo 02-04hr  (8257) embryo 04-06hr  (7449) embryo 06-08hr  (7326) embryo 08-10hr  (6481) embryo 10-12hr  (5438) embryo 12-14hr  (3495) embryo 14-16hr  (3568) embryo 16-18hr  (2799) embryo 18-20hr  (1771) embryo 20-22hr  (3443) embryo 22-24hr  (2838) larva L1  (1813) larva L2  1408 larva L3 12hr old    986 larva L3 puffstage 1-2  1463 larva L3 puffstage 3-6  (2072) larva L3 puffstage 7-9  (2624) white prepupae new  (2470) white prepupae 12hr  (2657) white prepupae 24hr  (2657) pupae 2d postWPP  (1539) pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day  (2327) adult female 05day  (3230) adult female 30day  (3488) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7559 embryo 02-04hr    8257 embryo 04-06hr    7449 embryo 06-08hr    7326 embryo 08-10hr    6481 embryo 10-12hr    5438 embryo 12-14hr    3495 embryo 14-16hr    3568 embryo 16-18hr    2799 embryo 18-20hr    1771 embryo 20-22hr    3443 embryo 22-24hr    2838 larva L1    1813 larva L2    1408 larva L3 12hr old    986 larva L3 puffstage 1-2    1463 larva L3 puffstage 3-6    2072 larva L3 puffstage 7-9    2624 white prepupae new    2470 white prepupae 12hr    2657 white prepupae 24hr    2657 pupae 2d postWPP    1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day    2327 adult female 05day    3230 adult female 30day    3488 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7559 embryo 02-04hr    8257 embryo 04-06hr    7449 embryo 06-08hr    7326 embryo 08-10hr    6481 embryo 10-12hr    5438 embryo 12-14hr    3495 embryo 14-16hr    3568 embryo 16-18hr    2799 embryo 18-20hr    1771 embryo 20-22hr    3443 embryo 22-24hr    2838 larva L1    1813 larva L2    1408 larva L3 12hr old    986 larva L3 puffstage 1-2    1463 larva L3 puffstage 3-6    2072 larva L3 puffstage 7-9    2624 white prepupae new    2470 white prepupae 12hr    2657 white prepupae 24hr    2657 pupae 2d postWPP    1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day    2327 adult female 05day    3230 adult female 30day    3488 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015602 expression level Developmental Stage   Expression Level embryo 00-02hr    7559 embryo 02-04hr    8257 embryo 04-06hr    7449 embryo 06-08hr    7326 embryo 08-10hr    6481 embryo 10-12hr    5438 embryo 12-14hr    3495 embryo 14-16hr    3568 embryo 16-18hr    2799 embryo 18-20hr    1771 embryo 20-22hr    3443 embryo 22-24hr    2838 larva L1    1813 larva L2    1408 larva L3 12hr old    986 larva L3 puffstage 1-2    1463 larva L3 puffstage 3-6    2072 larva L3 puffstage 7-9    2624 white prepupae new    2470 white prepupae 12hr    2657 white prepupae 24hr    2657 pupae 2d postWPP    1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day    2327 adult female 05day    3230 adult female 30day    3488 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7559) embryo 02-04hr  (8257) embryo 04-06hr  (7449) embryo 06-08hr  (7326) embryo 08-10hr  (6481) embryo 10-12hr  (5438) embryo 12-14hr  (3495) embryo 14-16hr  (3568) embryo 16-18hr  (2799) embryo 18-20hr  (1771) embryo 20-22hr  (3443) embryo 22-24hr  (2838) larva L1  (1813) larva L2  (1408) larva L3 12hr old  (986) larva L3 puffstage 1-2  (1463) larva L3 puffstage 3-6  (2072) larva L3 puffstage 7-9  (2624) white prepupae new  (2470) white prepupae 12hr  (2657) white prepupae 24hr  (2657) pupae 2d postWPP  (1539) pupae 3d postWPP  (913) pupae 4d postWPP  (1004) adult male 01day  (841) adult male 05day  (958) adult male 30day  (1082) adult female 01day  (2327) adult female 05day  (3230) adult female 30day  (3488) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7559) embryo 02-04hr  (8257) embryo 04-06hr  (7449) embryo 06-08hr  (7326) embryo 08-10hr  (6481) embryo 10-12hr  (5438) embryo 12-14hr  (3495) embryo 14-16hr  (3568) embryo 16-18hr  (2799) embryo 18-20hr  1771 embryo 20-22hr  (3443) embryo 22-24hr  (2838) larva L1  1813 larva L2  1408 larva L3 12hr old    986 larva L3 puffstage 1-2  1463 larva L3 puffstage 3-6  2072 larva L3 puffstage 7-9  (2624) white prepupae new  2470 white prepupae 12hr  (2657) white prepupae 24hr  (2657) pupae 2d postWPP  1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day  2327 adult female 05day  (3230) adult female 30day  (3488) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7559 embryo 02-04hr    8257 embryo 04-06hr    7449 embryo 06-08hr    7326 embryo 08-10hr    6481 embryo 10-12hr    5438 embryo 12-14hr    3495 embryo 14-16hr    3568 embryo 16-18hr    2799 embryo 18-20hr    1771 embryo 20-22hr    3443 embryo 22-24hr    2838 larva L1    1813 larva L2    1408 larva L3 12hr old    986 larva L3 puffstage 1-2    1463 larva L3 puffstage 3-6    2072 larva L3 puffstage 7-9    2624 white prepupae new    2470 white prepupae 12hr    2657 white prepupae 24hr    2657 pupae 2d postWPP    1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day    2327 adult female 05day    3230 adult female 30day    3488 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7559 embryo 02-04hr    8257 embryo 04-06hr    7449 embryo 06-08hr    7326 embryo 08-10hr    6481 embryo 10-12hr    5438 embryo 12-14hr    3495 embryo 14-16hr    3568 embryo 16-18hr    2799 embryo 18-20hr    1771 embryo 20-22hr    3443 embryo 22-24hr    2838 larva L1    1813 larva L2    1408 larva L3 12hr old    986 larva L3 puffstage 1-2    1463 larva L3 puffstage 3-6    2072 larva L3 puffstage 7-9    2624 white prepupae new    2470 white prepupae 12hr    2657 white prepupae 24hr    2657 pupae 2d postWPP    1539 pupae 3d postWPP    913 pupae 4d postWPP    1004 adult male 01day    841 adult male 05day    958 adult male 30day    1082 adult female 01day    2327 adult female 05day    3230 adult female 30day    3488 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015602    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015602 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015602 expression level Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary    505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary  505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary    505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary    505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015602 expression level Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary    505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary  505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary    505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    296.025 Larval Midgut    70.8 Larval Hindgut    95 Larval Malpighian Tubules    145.2 Larval Fat Body    105.3 Larval Salivary Gland    227.6 Larval Trachea    294.35 Larval Carcass    127.5 Adult Head    124.1 Adult Eye    209.8 Adult Brain    223 Adult Thoracic-Abdominal Ganglion    191.4 Adult Crop    108.3 Adult Midgut    74.8 Adult Hindgut    99.9 Adult Malpighian Tubules    100.4 Adult Fat Body    65.8 Adult Salivary Gland    113.4 Adult Heart    104.925 Adult VirginFemale Spermatheca    91.3 Adult InseminatedFemale Spermatheca    104.9 Adult Ovary    505 Adult Testis    60.4 Adult Male Accessory Gland    94.9 Adult Carcass    88.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    124.1   NA  Eye    209.8   NA  Brain    223   296.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    191.4   NA  Crop    108.3   70.8  Midgut    74.8   95  Hindgut    99.9   145.2  Malpighian Tubules    100.4   105.3  Fat Body    65.8   227.6  Salivary Gland    113.4   NA  Heart    104.925   294.35  Trachea    NA   NA  VirginFemale Spermatheca    91.3   NA  InseminatedFemale Spermatheca    104.9   NA  Ovary    505   NA  Testis    60.4   NA  Male Accessory Gland    94.9   127.5  Carcass    88.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015602 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10159-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for BEAF-32 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect | partially | recessive BEAF-32AB-KO lethal | partially, with Scer\GAL4da.G32 BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 viable, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa viable, with Scer\GAL4pnr-MD237 BEAF-32GD4418 BEAF-32GD13743 viable (with BEAF-32A-KO.3') BEAF-32A-KO.5' viable (with BEAF-32A-KO.5') BEAF-32A-KO.3' viable | poor BEAF-32AB-KO Sterility Allele female sterile | partially | recessive BEAF-32AB-KO fertile, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa fertile (with BEAF-32A-KO.3') BEAF-32A-KO.5' fertile (with BEAF-32A-KO.5') BEAF-32A-KO.3' male fertile BEAF-32AB-KO Other Phenotypes Allele enhancer of variegation, with In(1)wm4h, Scer\GAL4ey.PH BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 enhancer of variegation, with P{SUPor-P}KV20, Scer\GAL4y.PG BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 enhancer of variegation | dominant, with In(1)wm4h BEAF-32AB-KO enhancer of variegation | dominant, with P{SUPor-P}KV0123 BEAF-32AB-KO increased cell death, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa suppressor of variegation, with In(1)wm4h BEAF-32+t5 suppressor of variegation, with P{SUPor-P}KV20 BEAF-32+t5 visible, with Scer\GAL4ey.PH BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 visible, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa visible | recessive BEAF-32AB-KO Phenotype manifest in Allele egg chamber BEAF-32AB-KO eye BEAF-32AB-KO eye, with Scer\GAL4ey.PH BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 eye, with Scer\GAL4GMR.PF BEAF-32Scer\UAS.cYa eye disc, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa interommatidial bristle, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa nurse cell | supernumerary BEAF-32AB-KO ommatidium, with Scer\GAL4ey.PH BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 ommatidium, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa polytene chromosome | third instar larval stage, with Scer\GAL434B BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 polytene chromosome | third instar larval stage, with Scer\GAL4AB1 BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 rhabdomere, with Scer\GAL4GMR.PS BEAF-32Scer\UAS.cYa X chromosome | male BEAF-32AB-KO X chromosome | male (with BEAF-32A-KO.3') BEAF-32A-KO.5' X chromosome | male (with BEAF-32A-KO.5') BEAF-32A-KO.3'
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of BEAF-32 Class Mutagen Stocks Known lesion BEAF-325-HA-1129 1 -- BEAF-32e00756 piggyBac transposase 1 -- BEAF-32KG06904 P-element activity 1 -- BEAF-32NP6377 1 -- BEAF-32A-KO.3' FLPase SCEI endonuclease recombination 0 Yes BEAF-32A-KO.5' FLPase SCEI endonuclease recombination 0 Yes BEAF-32AB-KO FLPase SCEI endonuclease recombination I-CreI endonuclease 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of BEAF-32 Class Mutagen Stocks Known lesion BEAF-32GD13743 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes BEAF-32GD4418 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BEAF-32GLV21006 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BEAF-32HM05202 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BEAF-32+t5 in vitro construct - genomic fragment 0 Yes BEAF-32BID.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BEAF-32mBF.Scer\SceI.RS in vitro construct - site directed mutagenesis 0 Yes BEAF-32Pc.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BEAF-32Scer\UAS.cYa in vitro construct - regulatory fusion 0 Yes BEAF-32T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4418} NA P{GD13743} NA P{TRiP.GLV21006} NA P{TRiP.HM05202} NA P{UAS-BEAF-32.BID} NA P{UAS-BEAF-32.Y} NA characterization construct P{BEAF-32-EGFP} NA P{C4-gBF} NA P{FRT(w+.mBF)} NA P{Pc-BEAF-32.FLAG} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}BEAF-325-HA-1129 NA P{SUPor-P}BEAF-32KG06904 NA PBac{RB}BEAF-32e00756 NA insertion of enhancer trap binary system P{GawB}BEAF-32NP6377 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
chromatin insulator sequence binding inferred from direct assay (Zhao et al., 1995, Cuvier et al., 1998) DNA binding inferred from direct assay (Hart et al., 1997) protein binding inferred from physical interaction with dwg (Blanton et al., 2003)
Biological Process
CV term Evidence References
chromatin organization inferred from mutant phenotype (Roy et al., 2007) histone H3-K9 methylation inferred from direct assay (Emberly et al., 2008) oogenesis inferred from mutant phenotype (Roy et al., 2007) regulation of transcription from RNA polymerase II promoter inferred from direct assay (Zhao et al., 1995)
Cellular Component
CV term Evidence References
colocalizes_with nuclear chromatin inferred from direct assay (Zhao et al., 1995) nucleus inferred from direct assay (Hart et al., 1997)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions BEAF-32 allele Gene References BEAF-32Scer\UAS.cYa Dll (Yamaguchi et al., 2001) Dref (Yoshida et al., 2001) dwg (Blanton et al., 2003) kto (Yamaguchi et al., 2001) su(Hw) (Yamaguchi et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62391 DroID - A comprehensive database of gene and protein interactions. • FBgn0015602 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36645
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13135 Dere\GG20480 Dgri\GH21415 Dmoj\GI18590 Dper\GL11437 Dpse\GA10120 Dsec\GM21570 Dsim\GD11076 Dvir\GJ20389 Dwil\GK22912 Dyak\GE13610
Curated drosophilid orthologs	Dpse\GA10120
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • 312233 Daphnia pulex (daphnia) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231269 FBgn0224874 FBgn0207529 FBgn0187080 FBgn0182833 FBgn0176450 FBgn0070179 FBgn0149046 FBgn0141329 FBgn0128877 FBgn0112670 FBgn0090168 PHUM580690 PHUM623780
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	29734 y1 sc* v1; P{TRiP.HM05202}attP2 35642 y1 sc* v1; P{TRiP.GLV21006}attP2 14058 y1 w67c23; P{SUPor-P}BEAF-32KG06904
Harvard	- PBac{RB}BEAF-32e00756
Kyoto	125094 w1118; P{RS5}BEAF-325-HA-1129 105221 y* w*; P{GawB}BEAF-32NP6377 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v46519 w1118; P{GD4418}v46519 v23710 w1118; P{GD13743}v23710 v23711 w1118; P{GD13743}v23711
Genomic Clones ( 1 )
	BACR03K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44361 SD16942
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12061 LD39710 LD40215 RE02131 RE02622 RE02968 RE14237 RE18131 RE18719 RE20881 RE53287
Other clones	38910 51271 173432 178891 274423 277237 CK01.103C.D10 Dmel_dig_008846_0597_1332 Dmel_dig_013777_0608_0600 Dmel_dig_018565_0684_2411 EK014801 EK051035 EK066530 EK069235 EK136249 EK146036 EK151816 EK226043 EK250107 EK277641 EK284748 EK301943 EK304349 ESG017a.E21_B08 RM05259 RM05359 RM05659 RM06159 RM06259 RM06359 RM06559 RP001011585 RP001015109 RP001015232 RP001016751 RP001039183 RP001040445 RP001042144 RP001042746 RP001056443 RP003181805
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015602 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36645
Antibody Information
	polyclonal (Zhao et al., 1995, Hart et al., 1997, Hart et al., 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for BEAF-32 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) DNA-protein interactions: genome-wide binding profile assayed for BEAF-32 protein in 0-12 hr embryos; see Insulator_Class_I.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245). (Nègre et al., 2010) BEAF-32 is required for the insulator activity of scs', but not for the scs or gypsy\su(Hw)BR insulators. BEAF-32 function also affects chromatin structure or dynamics. (Roy et al., 2007) Dref and BEAF-32 may compete for binding to overlapping sites in vivo. (Hart et al., 1999) The properties of two BEAF-32 protein isoforms, which differ in their amino termini, have been analysed. (Hart et al., 1997) A novel protein that binds to scs' but not scs in vivo. Ecol\CAT assays in culture cells identify BEAF-32 together with the palindromic binding site within scs' as components of the scs' boundary function. (Zhao et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079023 NM_166069 RefSeq (Proteins) • NP_523747 NP_725418 DDBJ / EMBL / GenBank • AAF58205 AAG22264 AAL13940 AI512475 AI944686 AW943717 AY058711 BH809555 BH809556 CAA59994 CAA70621 CZ478603 X86007 Y09475 Entrez Gene - A searchable database of RefSeq genes. • 36645 UniProtKB/TrEMBL • Q7JN06 Q94513
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, BED-type predicted (IPR003656) BESS motif (IPR004210)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62391 DroID - A comprehensive database of gene and protein interactions. • FBgn0015602 DRSC - Results from RNAi screens. • FBgn0015602 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015602 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10159-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015602 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36645 InParanoid A subset of ortholog calls from InParanoid. • 312233 Daphnia pulex (daphnia) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36645 modMine - Data generated by the modENCODE project. • FBgn0015602 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231269 FBgn0224874 FBgn0207529 FBgn0187080 FBgn0182833 FBgn0176450 FBgn0070179 FBgn0149046 FBgn0141329 FBgn0128877 FBgn0112670 FBgn0090168 PHUM580690 PHUM623780 REDfly - A database of transcriptional regulatory elements. • FBgn0015602
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	BEAF (Hart et al., 2005, Hart et al., 2004, Ishii and Laemmli, 2003, Blanton et al., 2003, Cuvier et al., 2002, Hart and Starks, 2003, Arnosti, 2002, West et al., 2002, Hart et al., 2000, Hart et al., 1999, Hart et al., 1999, Cuvier et al., 1998, Geyer, 1997, Eggert et al., 2005, Berkaeva et al., 2007, Hart et al., 2007, Gilbert et al., 2006, Sultana et al., 2011, Roy et al., 2007, Roy et al., 2007, Roy and Hart, 2008, Jiang et al., 2008, Sage et al., 2005, Andreyeva et al., 2007, Pauli et al., 2008, Roy and Hart, 2010, modENCODE Consortium et al., 2010, Roy et al., 2011, Guertin and Lis, 2010) beaf (Emberly et al., 2008) Beaf-32 (Orlando, 2000) BEAF32 (Chambeyron and Bickmore, 2004, Moon et al., 2005, Rach et al., 2011, modENCODE Consortium et al., 2010, Oliver et al., 2010) BEAF-32 (Gilbert et al., 2006, Ramos et al., 2006, Richter et al., 2011, Reiter et al., 2007, Somma et al., 2008, Petesch and Lis, 2008, Dubois et al., 2007, Doheny et al., 2008, Pathak et al., 2007, van Steensel et al., 2010, Nègre et al., 2010, van Bemmel et al., 2010, modENCODE Consortium et al., 2010, Schoborg and Labrador, 2010, Berkaeva et al., 2009, Pruteanu-Malinici et al., 2011, Wallace et al., 2010, Vatolina et al., 2011, Vatolina et al., 2011) BEAF32A (Geyer and Clark, 2002, Yamaguchi et al., 2001) BEAF-32A (Aravind, 2000, Gerasimova and Corces, 2001, Udvardy, 1999, Gilbert and Hart, 2008) BEAF32B (Geyer and Clark, 2002) BEAF-32B (Gerasimova and Corces, 2001, Hart, 1996.11.15, Udvardy, 1999, Gilbert and Hart, 2008) BEAF32b (Filion et al., 2010) bs04c01.y1 (Andrews et al., 2000) CG10159 (Jin et al., 2001, Perkins et al., 2009, Ni et al., 2011.7.19)
Name Synonym	boundary element associated factor (Andrews et al., 2000) boundary element-associated factor (Roy et al., 2007, Emberly et al., 2008) boundary element associated factor 32 (Petesch and Lis, 2008) Boundary element-associated factor of 32kD (Zhao et al., 1995)
Secondary FlyBase IDs
	FBgn0013752
References ( 88 )
Generate a list of	All references relating to this gene ( 88 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 4 ) Review  ( 15 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 18 )
	Pruteanu-Malinici et al., 2011, PLoS Comput. Biol. 7(7): e1002098 Automatic Annotation of Spatial Expression Patterns via Sparse Bayesian Factor Models. [FBrf0214618] Rach et al., 2011, PLoS Genet. 7(1): e1001274 Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. [FBrf0214353] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Roy et al., 2011, Mol. Genet. Genomics 285(2): 113--123 Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. [FBrf0212912] Sultana et al., 2011, Nucleic Acids Res. 39(9): 3543--3557 A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. [FBrf0213641] Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 [Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster]. [FBrf0214456] Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster. [FBrf0216692] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Guertin and Lis, 2010, PLoS Genet. 6(9): Chromatin Landscape Dictates HSF Binding to Target DNA Elements. [FBrf0211835] modENCODE Consortium et al., 2010, Science 330(6012): 1787--1797 Identification of functional elements and regulatory circuits by Drosophila modENCODE. [FBrf0212741] Nègre et al., 2010, PLoS Genet. 6(1): e1000814 A comprehensive map of insulator elements for the Drosophila genome. [FBrf0209760] Oliver et al., 2010, BMC Cell Biol. 11: 101 The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. [FBrf0212850] Roy and Hart, 2010, Fly 4(1): 12--17 Targeted gene replacement by homologous recombination in Drosophila stimulates production of second-site mutations. [FBrf0210613] Schoborg and Labrador, 2010, J. Mol. Evol. 70(1): 74--84 The Phylogenetic Distribution of Non-CTCF Insulator Proteins Is Limited to Insects and Reveals that BEAF-32 Is Drosophila Lineage Specific. [FBrf0209931] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] van Bemmel et al., 2010, PLoS ONE 5(11): e15013 The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome. [FBrf0212466] Wallace et al., 2010, Chromosoma 119(2): 177--194 Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila. [FBrf0210229] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...