General Information
Symbol
Dmel\CadN
Species
D. melanogaster
Name
Cadherin-N
Annotation Symbol
CG7100
Feature Type
FlyBase ID
FBgn0015609
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Ncad, N-Cad, DNcad, N-cadherin, DN-Cad
Genomic Location
Cytogenetic map
Sequence location
2L:17,647,053..17,778,340 [-]
Recombination map
2-53
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
UniProt Contributed Function Data
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
(UniProt, O15943)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
l(2)36Da
Larval lethal.
Interactive Fly
cadherin - cell aggregation - regulates axon pathfinding - sequoia-induced axon targeting is mediated - through the ubiquitously expressed Cadherin-N cell adhesion molecule - Cooperates with E-cadherin to regulate the cell motility process of ommatidial rotation
Gene Model and Products
Number of Transcripts
12
Number of Unique Polypeptides
12

Please see the GBrowse view of Dmel\CadN or the JBrowse view of Dmel\CadN for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0081013
10412
3096
FBtr0081020
10412
3096
FBtr0081014
10409
3095
FBtr0081015
13384
3097
FBtr0081016
13228
3097
FBtr0081017
10412
3096
FBtr0081018
10412
3096
FBtr0081019
10409
3095
FBtr0100313
13237
3100
FBtr0100314
10421
3099
FBtr0100315
13237
3100
FBtr0100316
10427
3101
Additional Transcript Data and Comments
Reported size (kB)
15 (northern blot)
>10 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0080566
346.7
3096
4.64
FBpp0080573
346.9
3096
4.64
FBpp0080567
346.5
3095
4.68
FBpp0080568
347.2
3097
4.67
FBpp0080569
347.1
3097
4.67
FBpp0080570
347.0
3096
4.71
FBpp0080571
346.8
3096
4.71
FBpp0080572
346.6
3095
4.68
FBpp0099718
347.2
3100
4.64
FBpp0099719
346.9
3099
4.68
FBpp0099720
347.3
3100
4.71
FBpp0099721
347.5
3101
4.67
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
3097 (aa); 300 (kD observed)
Comments
CadN has 15 cadherin repeats in the extracellular region. Between the last cadherin repeat and the transmembrane domain, there are two cysteine-rich regions, an Fcc box (fly classic cadherin box) and a laminin A globular domain. The cytoplasmic domain is more similar to shg and vertebrate cadherins. Antibodies were prepared to the cytoplasmic domain and to the extracellular domain. Both recognize a pair of 300kD bands, the smaller of which is assumed to be the mature form of the protein. In addition, the antibodies to the extracellular and cytoplasmic portions recognize proteins of 200kD and 120kD, respectively. These are thought to be cleavage products. Immunoprecipitation experiments show that CadN protein binds to the neural form of arm protein. Expression of CadN in S2 cells leads to aggregation of the cells. CadN appears to be the major cadherin that assembles catenins in axons.
External Data
Domain
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
(UniProt, O15943)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CadN using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (26 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:CadN; FB:FBgn0015609
inferred from direct assay
inferred from physical interaction with UniProtKB:P18824-2
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
Biological Process (15 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:uzip; FB:FBgn0004055
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
non-traceable author statement
traceable author statement
inferred from sequence or structural similarity with FLYBASE:shg; FB:FBgn0003391
inferred from sequence or structural similarity with MGI:MGI:88355
inferred from sequence or structural similarity
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with MGI:MGI:88355
inferred from sequence or structural similarity
inferred from sequence or structural similarity with FLYBASE:shg; FB:FBgn0003391
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
CadN transcripts are first seen in nuclei of presumptive mesodermal cells prior to stage 5. Transport to the cytoplasm begins at around stage 6-7. By stage 8, transcripts are distributed throughout the nucleus.
CadN transcripts are most abundant in embryos on northern blots. CadN transcripts are expressed in developing neural cells, presumably at their postmitotic stage.
Marker for
 
Subcellular Localization
CV Term
cytoplasm nucleus
Polypeptide Expression
immuno-electron microscopy
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
lamina

Comment: reference states 40% pupal development

medulla

Comment: reference states 40% pupal development

optic cartridge

Comment: reference states 75% pupal development

mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
CadN protein is expressed in the cell bodies of neurons of the medulla anlage in third instar larva, but it is more strongly expressed in the inner domain, where hth is expressed.
At 25 hr APF, CadN is strongly expressed between the R7 and R8 growth cones that mark the boundaries of the outer medulla at this stage. By 48 hr APF, the region has divided into two CadN-rich regions divided by a zone of weaker staining. At 75 hr APF prominent CadN expression is seen in a single layer in the distal part of the outer medulla. Strong CadN expression is seen in M2 in later pual stages. CadN is strongly expressed on growth cones of lamina neurons during development.
CadN is localized to the adherens junctions of the cell-cell interfaces of cone cells.
In adults, immunogold-labeled antibodies to CadN cluster at the periphery of the synaptic cleft, juxtaposed to the active zones, in the optic cartridges. The affected synapses appear to be between R1--R6 axons and spines of L-cells (lamina monopolar neurons).
CadN protein is first seen at intercellular contacts in the mesoderm at stage 9. It is then detected at the boundaries of mesodermally-derived cells including myoblasts and myotubes. CadN is also found in developing neural cells, presumably at the postmitotic stage. Subsequently, the protein accumulates in axons in the entire CNS. In third instar larvae, it is expressed in CNS neuropil, photoreceptor axons, and precursors of adult muscles.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CadN in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Allele of CadN
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
    Other relevant insertions
    Transgenic Constructs ( 18 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of CadN
    Allele of CadN
    Mutagen
    Associated Transgenic Construct
    Stocks
    Transgenic constructs containing regulatory region of CadN
    reporter construct
    Name
    Expression Data
    Deletions and Duplications ( 37 )
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Other Phenotypes
    Allele
    Phenotype manifest in
    Allele
    eye photoreceptor cell & axon | somatic clone | cell autonomous
    photoreceptor cell R1 & axon | somatic clone
    photoreceptor cell R2 & axon | somatic clone
    photoreceptor cell R3 & axon | somatic clone
    photoreceptor cell R4 & axon | somatic clone
    photoreceptor cell R5 & axon | somatic clone
    photoreceptor cell R6 & axon | somatic clone
    photoreceptor cell R7 & axon | somatic clone
    Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (9)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
     
    1 of 15
    No
    No
    1 of 15
    No
    No
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (22)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    2 of 15
    Yes
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    Rattus norvegicus (Norway rat) (20)
    2 of 13
    Yes
    No
    2 of 13
    Yes
    No
    2 of 13
    Yes
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    Yes
    Xenopus tropicalis (Western clawed frog) (4)
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    Yes
    Danio rerio (Zebrafish) (10)
    12 of 15
    Yes
    Yes
    10 of 15
    No
    Yes
    2 of 15
    No
    Yes
    2 of 15
    No
    No
    2 of 15
    No
    No
    2 of 15
    No
    No
    2 of 15
    No
    No
    2 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (4)
    10 of 15
    Yes
    Yes
    2 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    Arabidopsis thaliana (thale-cress) (0)
    No orthologs reported.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No orthologs reported.
    Schizosaccharomyces pombe (Fission yeast) (1)
    1 of 12
    Yes
    Yes
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919002J )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila melanogaster
    fruit fly
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915006W )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Glossina morsitans
    Tsetse fly
    Lucilia cuprina
    Australian sheep blowfly
    Mayetiola destructor
    Hessian fly
    Aedes aegypti
    Yellow fever mosquito
    Anopheles darlingi
    American malaria mosquito
    Anopheles gambiae
    Malaria mosquito
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01BL )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Bombyx mori
    Silkmoth
    Danaus plexippus
    Monarch butterfly
    Danaus plexippus
    Monarch butterfly
    Heliconius melpomene
    Postman butterfly
    Heliconius melpomene
    Postman butterfly
    Apis florea
    Little honeybee
    Apis florea
    Little honeybee
    Apis mellifera
    Western honey bee
    Apis mellifera
    Western honey bee
    Bombus impatiens
    Common eastern bumble bee
    Bombus impatiens
    Common eastern bumble bee
    Bombus terrestris
    Buff-tailed bumblebee
    Bombus terrestris
    Buff-tailed bumblebee
    Linepithema humile
    Argentine ant
    Linepithema humile
    Argentine ant
    Megachile rotundata
    Alfalfa leafcutting bee
    Megachile rotundata
    Alfalfa leafcutting bee
    Megachile rotundata
    Alfalfa leafcutting bee
    Nasonia vitripennis
    Parasitic wasp
    Dendroctonus ponderosae
    Mountain pine beetle
    Dendroctonus ponderosae
    Mountain pine beetle
    Tribolium castaneum
    Red flour beetle
    Pediculus humanus
    Human body louse
    Pediculus humanus
    Human body louse
    Rhodnius prolixus
    Kissing bug
    Rhodnius prolixus
    Kissing bug
    Cimex lectularius
    Bed bug
    Cimex lectularius
    Bed bug
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Zootermopsis nevadensis
    Nevada dampwood termite
    Zootermopsis nevadensis
    Nevada dampwood termite
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00DG )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Strigamia maritima
    European centipede
    Ixodes scapularis
    Black-legged tick
    Ixodes scapularis
    Black-legged tick
    Stegodyphus mimosarum
    African social velvet spider
    Stegodyphus mimosarum
    African social velvet spider
    Stegodyphus mimosarum
    African social velvet spider
    Stegodyphus mimosarum
    African social velvet spider
    Stegodyphus mimosarum
    African social velvet spider
    Tetranychus urticae
    Two-spotted spider mite
    Daphnia pulex
    Water flea
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00V9 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Human Disease Model Data
    FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 1 )
    Allele
    Disease
    Evidence
    References
    model of  prostate cancer
    inferred from mutant phenotype
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-53
    Cytogenetic map
    Sequence location
    2L:17,647,053..17,778,340 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    36D2-36D2
    Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    36D-36D
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    2-53.1
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (25)
    Genomic Clones (59)
    cDNA Clones (35)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: CadN CG7100
    Source for database merge of
    Source for merge of: CadN anon- EST:CL32
    Additional comments
    Other Comments
    The CadN protein, along with CadN2, acts to restrict ommatidial rotation.
    ChEST reveals this is a target of Mef2.
    Alternative exon 18A encodes for isoforms that are required for R1-R7 targeting.
    CadN is required in both individual photoreceptors and their target neurons for photoreceptor axon extension. CadN and CadN2 appear to function redundantly in this process.
    CadN is necessary for shaping cone cell clusters in the retina.
    CadN plays a crucial role in protoglomerulus formation but is largely dispensible for targeting olfactory receptor neurons to the appropriate region of the antennal lobe.
    CadN does not have an instructive role in selecting dendritic targets in the projection neurons, but rather is essential for projection neurons to restrict their dendrites to single glomeruli. CadN appears to mediate dendro-dendritic interactions between projection neurons. CadN is also essential for the development of projection neuron axon terminal arbors at two distinct targets; regulating branch stability in the lateral horn and restricting high-order branching in the mushroom body.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    CadN has a role in regulating synaptic target specificity in the visual system.
    Mutants exhibit various defects in axon fascicle formation.
    Mutant analysis suggests that processes of axon patterning critically depend on CadN-mediated axon-axon interactions.
    Isolated from a subtractive cDNA library enriched in sequences expressed in the mesoderm.
    A CadN cDNA has been cloned and sequenced. CadN is expressed in the early mesoderm.
    CadN is recognised by anti-C-NCAD(838-856), probe derived from the chicken N-cadherin.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 87 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    modMine - A data warehouse for the modENCODE project
    Synonyms and Secondary IDs (41)
    Reported As
    Symbol Synonym
    S(DmcycEJP)2.12
    anon-EST:CL32
    Name Synonyms
    DN-CADHERIN
    DN-cadherin1
    Drosophila neuronal cadherin
    N-CADHERIN
    lethal(2)36Da
    n-cadherin
    Secondary FlyBase IDs
    • FBgn0002007
    • FBgn0019859
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (319)