FlyBase Gene Report: Dmel\CanB2

General Information

Symbol

Dmel\CanB2

Species

D. melanogaster

Name

Calcineurin B2

Annotation Symbol

CG11217

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015614

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase. (UniProt, Q24214)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

dCnB2

Key Links

Genomic Location

Cytogenetic map

43E16-43E16

Sequence location

2R:7,786,010..7,789,053 [+]

Recombination map

2-57

RefSeq locus

NT_033778 REGION:7786010..7789053

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9XZL8

(assigned by UniProt )

(Takeo et al., 2012)

inferred from physical interaction with FLYBASE:sra; FB:FBgn0086370

(Takeo et al., 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(Warren et al., 1996)

enables calcium-dependent protein serine/threonine phosphatase regulator activity

inferred from electronic annotation with InterPro:IPR015757

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(Warren et al., 1996)

enables calmodulin binding

inferred from sequence or structural similarity

(Warren et al., 1996)

Biological Process (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in meiotic cell cycle

inferred from mutant phenotype

(Takeo et al., 2010)

involved_in sarcomere organization

inferred from mutant phenotype

(Gajewski et al., 2006)

involved_in skeletal muscle myosin thick filament assembly

inferred from mutant phenotype

(Gajewski et al., 2006)

involved_in sleep

inferred from direct assay

(Nakai et al., 2011, Tomita et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in neurotransmitter secretion

non-traceable author statement

(Lloyd et al., 2000)

involved_in protein dephosphorylation

inferred from sequence or structural similarity

(Warren et al., 1996)

involved_in vesicle-mediated transport

non-traceable author statement

(Lloyd et al., 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of calcineurin complex

inferred from sequence or structural similarity

(Warren et al., 1996)

located_in synaptic vesicle

non-traceable author statement

(Lloyd et al., 2000)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the calcineurin regulatory subunit family. (Q24214)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.

(UniProt, Q24214)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CanB2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24214)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CanB2-RA

FBtr0088930

NM_080135

1143

170

CanB2-RB

FBtr0309866

NM_001259263

2061

170

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CanB2-PA

FBpp0088004

19.3

170

4.30

NP_524874

AAF59195

CanB2-PB

FBpp0301600

19.3

170

4.30

NP_001246192

AFH07947

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

170 aa isoforms: CanB2-PA, CanB2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

170 (aa)

(Warren et al., 1996)

Comments

External Data

Subunit Structure (UniProtKB)

Composed of a catalytic subunit (A) and a regulatory subunit (B) (By similarity). Interacts with sra.

(UniProt, Q24214)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CanB2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanB2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

adult stage

adult optic lobe

(Tomita et al., 2011)

adult brain

(Tomita et al., 2011)

retina

(Tomita et al., 2011)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage -- adult stage

(Warren et al., 1996)

Additional Descriptive Data

CanB2 is widely expressed in the adult brain, optic lobe, and retina.

(Tomita et al., 2011)

CanB and CanB2 have over 98% amino acid identity. A CanB2 probe detects two transcripts, 2.3 and 1.6 kb, in Northern blots of pupal, larval, and adult stages. The genomic sequence of CanB2 is consistent with its being the 1.6 kb transcript, but further evidence is necessary. The 1.6 kb transcript is found in pupal, larval, and adult stages, with highest levels in in whole adults and adult heads. The 2.3 kb transcript is found in all developmental stages examined, with lower levels in larvae and early pupae.

(Warren et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Tomita et al., 2011)

Additional Descriptive Data

Protein was detected in the entire adult brain. An antibody agains a mammalian CnB subunit was used, which recognizes both CanB and CanB2 proteins.

(Tomita et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CanB2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CanB2

View exonic expression by tissue for Dmel\CanB2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015614

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46456/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015614

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015614

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015614

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11217

Flygut - An atlas of the Drosophila adult midgut

FBgn0015614

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CanB2

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CanB2

Transgenic constructs containing regulatory region of CanB2

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(2R)Exel6054

(Ryder, 2004.4.26)

Df(2R)ST1

(Gajewski et al., 2003)

In(2R)CanB2⁸⁷

(Sullivan and Rubin, 2002)

Gene not disrupted in

Df(2R)6149

(Takeo et al., 2010)

Df(2R)Exel6055

(Takeo et al., 2010)

Gene partially disrupted in

Df(2R)cn-W1

(Watanabe et al., 2009)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | larval stage | recessive

CanB2¹⁸⁰

lethal | pupal stage | recessive

CanB2¹⁸⁰

lethal | recessive

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

CanB2^GD13435

partially lethal - majority die

CanB2^x1

partially lethal - majority die, with Scer\GAL4^- :

CanB2^EP774

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CanB2^GD13435

viable, with Scer\GAL4^pnr-MD237

CanB2^GD13435

viable, with Scer\GAL4^tin.CΔ4

CanB2^GD13435

Sterility

Allele

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

CanB2^HMS01886

female sterile | germline clone

CanB2^EP774

Other Phenotypes

Allele

abnormal meiotic cell cycle | germline clone

CanB2^EP774

abnormal sleep

CanB2^KO

abnormal sleep, with Scer\GAL4^elav-C155

CanB2^GD13435

abnormal smell perception, with Scer\GAL4^elav-C155

CanB2^GD13435

flightless

CanB2^x1

flightless, with Scer\GAL4^- :

CanB2^EP774

hyperactive, with Scer\GAL4^elav-C155

CanB2^GD13435

visible, with Scer\GAL4^pnr-MD237

CanB2^GD13435

Phenotype manifest in

Allele

dorsal medial indirect flight muscle cell, with Scer\GAL4^- :

CanB2^EP774

dorsal medial indirect flight muscle cell (with CanB2¹⁸⁰), with Scer\GAL4^- :

CanB2^EP774

dorsal medial indirect flight muscle cell (with CanB2^EP774), with Scer\GAL4^- :

CanB2¹⁸⁰

dorsal medial indirect flight muscle cell (with Df(2R)ST1), with Scer\GAL4^- :

CanB2^EP774

dorsal medial indirect flight muscle cell | P-stage, with Scer\GAL4^- :

CanB2^EP774

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

CanB2^HMS01886

indirect flight muscle cell, with Scer\GAL4^- :

CanB2^EP774

indirect flight muscle cell (with CanB2¹⁸⁰), with Scer\GAL4^- :

CanB2^EP774

indirect flight muscle cell (with CanB2^EP774), with Scer\GAL4^- :

CanB2¹⁸⁰

indirect flight muscle cell (with Df(2R)ST1), with Scer\GAL4^- :

CanB2^EP774

indirect flight muscle cell | P-stage, with Scer\GAL4^- :

CanB2^EP774

myofibril, with Scer\GAL4^- :

CanB2^EP774

sarcomere, with Scer\GAL4^- :

CanB2^EP774

trichogen cell, with Scer\GAL4^pnr-MD237

CanB2^GD13435

wing, with Scer\GAL4^- :

CanB2^EP774

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PPP3R1

12 of 15

Yes

Hsap\PPP3R2

8 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ppp3r1

14 of 15

Yes

Mmus\Ppp3r2

8 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (17)

Rnor\Ppp3r1

9 of 13

Yes

Rnor\Ppp3r2

7 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Rcvrn

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\ppp3r1

13 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\rcvrn.1

1 of 12

Xtro\rcvrn.2

1 of 12

Xtro\tesc

1 of 12

Yes

Danio rerio (Zebrafish) (27)

Drer\ppp3r1b

13 of 15

Yes

Drer\ppp3r1a

11 of 15

Yes

Drer\chp1

2 of 15

Drer\chp2

2 of 15

Drer\LOC100536377

2 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-103a14.5

1 of 15

Drer\si:ch211-245j22.3

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\cnb-1

15 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (25)

Atha\AT3G18430

6 of 9

Yes

Atha\CBL6

2 of 9

Atha\AGD11

1 of 9

Yes

Atha\AT1G05990

1 of 9

Yes

Atha\AT2G36180

1 of 9

Yes

Atha\AT3G03400

1 of 9

Yes

Atha\AT3G03410

1 of 9

Yes

Atha\AT3G59440

1 of 9

Yes

Atha\AT3G59450

1 of 9

Yes

Atha\AT4G03290

1 of 9

Yes

Atha\AT5G17470

1 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Yes

Atha\CPK30

1 of 9

Atha\MSS3

1 of 9

Yes

Atha\SOS3

1 of 9

Atha\TCH2

1 of 9

Yes

Atha\UNE14

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CNB1

14 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC830.06

11 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

9 of 10

elm

4 of 10

3 of 10

3 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

CanB2^EP774

ameliorates cardiomyopathy

modeled by Pp2B-14D^act.UAS.EYFP

(Lee et al., 2014)

CanB2^GD13435

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanB2^KO

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanB2^KK107988

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanB2^JF02583

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP3R1; protein phosphatase 3 regulatory subunit B, alpha

12 of 15

601302

PPP3R2; protein phosphatase 3 regulatory subunit B, beta

8 of 15

613821

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CanB2 - CanB

experimental knowledge based

(Guruharsha et al., 2011)

CanB2 - sra

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, multidimensional protein identification technology

(Takeo et al., 2012, Takeo et al., 2006)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CanB2

suppressible

CanB

(Sullivan and Rubin, 2002)

CanB2

suppressible

fliI

(Gajewski et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Mhc

enhanceable

CanB2

(Gajewski et al., 2006)

Pp2B-14D

suppressible

CanB2

(Lee et al., 2014, Takeo et al., 2010, Sullivan and Rubin, 2002)

External Data

Subunit Structure (UniProtKB)

Composed of a catalytic subunit (A) and a regulatory subunit (B) (By similarity). Interacts with sra.

(UniProt, Q24214 )

Linkouts

BioGRID - A database of protein and genetic interactions.

70250

DroID - A comprehensive database of gene and protein interactions.

FBgn0015614

MIST (genetic) - An integrated Molecular Interaction Database

CanB2

MIST (protein-protein) - An integrated Molecular Interaction Database

CanB2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015614

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-57

Cytogenetic map

43E16-43E16

Sequence location

2R:7,786,010..7,789,053 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

43E16-43E16

Limits computationally determined from genome sequence between P{PZ}l(2)08492⁰⁸⁴⁹² and P{EP}CanB2^EP774

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

43E-43E

(Lloyd et al., 2000, Warren, 1996.4.23)

43D-43E

(determined by in situ hybridisation)

(Warren et al., 1996)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

2-57

(FlyBase, 2016)

2-57.0

(Comeron et al., 2012)

(Warren, 1996.4.23)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17296

w¹¹¹⁸; P{EP}CanB2^EP774

27270

y¹ v¹; P{TRiP.JF02583}attP2

80790

y¹, v¹; P{TKO.GS04583}attP40/CyO

83254

y¹ w^*; TI{CRIMIC.TG4.0}CanB2^{CR01186-TG4.0}/SM6a

38971

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01886}attP2

Kyoto

103627

w^*; P{GawB}CanB2^NP0512 / CyO

VDRC

v104370

P{KK107988}VIE-260B

v28762

w¹¹¹⁸; P{GD13435}v28762

v342120

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01602}attP40/CyO-GFP

v342315

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02064}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (48)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015614

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015614

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46456

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CanB2 CG11217

(Bayraktaroglu, 2000.4.13)

Additional comments

The CanB gene may be derived from the CanB2 gene by retroposition.

(Betran et al., 2002)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

5 alleles of "CS2-1" have been isolated.

(Sullivan and Rubin, 2002)

Identification: Molecular analysis of the cn gene region.

(Warren et al., 1996)

CanB2 has been cloned and sequenced, and compared with CanB.

(Warren et al., 1996)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46456

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24214

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24214

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4K833

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24214

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015614

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015614

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46456/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015614

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanB2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015614

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015614

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11217

Flygut - An atlas of the Drosophila adult midgut

FBgn0015614

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015614

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46456

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007534

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11217

MARRVEL_MODEL - MARRVEL (model organism gene)

46456

modMine - A data warehouse for the modENCODE project

FBgn0015614

Linkouts

BioGRID - A database of protein and genetic interactions.

70250

DroID - A comprehensive database of gene and protein interactions.

FBgn0015614

DRSC - Results frm RNAi screens

FBgn0015614

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015614

FlyMine - An integrated database for Drosophila genomics

FBgn0015614

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

CanB2

MIST (protein-protein) - An integrated Molecular Interaction Database

CanB2

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG11217

(Kanamori et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Whitfield, 2002.7.22, Mount, 2001.8.14, Verstreken and Bellen, 2000.9.4)

CS2-1

(Sullivan and Rubin, 2002)

CaN

(Toprak et al., 2020)

canB2

(Goel et al., 2019, Hughes et al., 2018, Kanamori et al., 2013, Younger et al., 2013, Gajewski et al., 2006, Gajewski et al., 2005, Schulz and Yutzey, 2004, Gajewski et al., 2003, Sullivan and Rubin, 2002, Sullivan and Rubin, 2002)

dCNB2

(Warren, 1996.4.23)

dCnB2

(Eeken et al., 2001, Warren et al., 1996, Warren et al., 1996)

Name Synonyms

Calcineurin B2

(John et al., 2016, Watanabe et al., 2009, Harbison et al., 2005)

Calcineurin suppressor, chromosome 2, group 1

(Sullivan and Rubin, 2002)

calcineurin B2

(Chang and Min, 2005)

Secondary FlyBase IDs